Med4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000017170	0.03	0.02	1.0e-03	0.02	0.02	0.02	0.02	1.5e-03	1.9e-03	6.2e-03	3.8e-03
2	Brain	gene expression	ENSRNOG00000017170	0.08	0.04	1.0e-07	0.1	0.08	0.09	0.09	1.9e-09	7.2e-08	2.9e-08	2.4e-08
3	Liver	alternative polyA	ENSRNOT00000023195	0.04	0.03	7.3e-05	0.03	0.03	0.03	0.03	4.8e-04	3.7e-04	3.0e-04	3.5e-04
4	Liver	gene expression	ENSRNOG00000017170	0.07	0.05	6.9e-06	0.04	0.03	0.02	0.03	2.8e-05	2.0e-04	3.2e-03	2.5e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4
BMI with tail	0.1	0.2	0.4	-0.5	0.4	-0.6	0.1
BMI without tail	0.4	0.7	2.7	0.4	1.6	0.4	-0.0
Body weight	0.6	2.6	6.6	1.4	1.0	-2.6	1.0
Epididymis fat weight	1.1	2.7	4.5	2.1	2.1	-0.1	1.4
Glucose	0.6	0.9	2.6	-1.6	-0.0	-0.6	-0.7
Heart weight	0.5	0.7	2.1	0.5	-0.1	1.5	-0.7
Left kidney weight	1.0	2.8	9.4	3.1	1.3	-0.3	0.1
Right kidney weight	2.0	5.6	20.4	4.5	1.4	0.6	-0.2
Tail length	0.7	2.2	5.6	2.4	1.7	-0.2	-0.3
Length with tail	0.5	2.0	3.9	1.7	0.3	-2.0	1.1
Length without tail	0.8	1.7	3.1	-0.1	-1.7	-1.8	0.9
Liver weight, left	0.1	0.2	0.3	-0.4	-0.5	-0.3	0.5
Liver weight, right	0.5	0.8	2.1	-0.9	-0.1	-1.5	-0.2
Parametrial fat weight	0.6	1.2	2.6	0.2	1.6	-0.0	1.5
Retroperitoneal fat weight	0.4	1.5	3.5	0.7	1.0	-0.9	1.9
Intraocular pressure	0.5	0.8	1.4	0.5	1.2	-0.5	1.0
Extensor digitorum longus weight	3.6	14.3	29.1	-4.2	-5.4	1.4	-3.0
Soleus weight	2.6	7.6	14.1	-3.8	-3.7	0.7	-1.4
Tibialis anterior weight	2.3	7.8	17.1	-2.8	-4.1	0.4	-2.5
Tibia length	4.0	11.4	28.7	5.4	3.0	-2.6	1.0
Number of licking bursts	1.3	1.6	3.5	0.1	1.2	-1.9	1.2
Food consumed during 24 hour testing period	0.6	0.8	1.8	0.9	-0.3	0.6	-1.3
Times rat made contact with spout	1.9	2.1	4.3	0.9	2.1	-1.7	0.8
Mean time between licks in bursts	0.5	0.6	1.5	0.3	0.9	1.2	-0.4
Mean num. licks in bursts	0.1	0.1	0.3	0.2	0.3	0.2	-0.6
Std. dev. time between licks in bursts	2.0	2.3	4.9	2.2	0.8	1.8	-0.7
Water consumed over 24 hours	0.2	0.2	0.6	0.2	-0.2	-0.3	-0.8
Indifference point 0 sec	2.7	4.3	9.9	3.1	2.3	-1.4	0.4
Indifference point AUC	1.5	1.8	3.0	-1.7	-1.2	1.3	-1.1
Indifference point function ln k	1.5	2.1	4.0	2.0	1.2	-1.4	1.1
Indifference point function log k	1.5	2.1	4.0	2.0	1.2	-1.4	1.1
Delay discounting total patch changes 0 sec	2.6	4.2	8.8	3.0	2.3	-1.6	0.6
Delay discounting total patch changes 12 sec	0.5	0.7	1.5	1.2	0.8	-0.5	-0.6
Delay discounting total patch changes 18 sec	0.9	1.2	2.3	0.2	1.5	-1.3	0.8
Delay discounting total patch changes 24 sec	0.8	1.0	2.0	1.4	1.0	-0.9	-0.3
Delay discounting total patch changes 6 sec	1.6	2.4	3.7	1.0	1.9	-1.5	1.6
Delay discounting time to switch 0 sec	0.0	0.0	0.1	0.1	-0.3	0.3	0.0
Delay discounting water rate 0 sec	1.0	1.6	4.2	0.8	1.1	-2.0	0.5
Delay discounting water rate 12 sec	0.2	0.3	1.2	0.0	-0.1	-0.3	1.1
Delay discounting water rate 18 sec	0.3	0.4	0.8	-0.4	0.2	-0.7	0.9
Delay discounting water rate 24 sec	2.0	2.7	4.7	-0.6	1.3	-2.2	2.0
Delay discounting water rate 6 sec	0.2	0.3	1.1	-0.5	-0.2	-1.0	0.0
Locomotor activity	2.5	3.9	8.4	1.0	-2.9	0.3	-2.5
Locomotor testing distance	1.2	2.0	2.7	1.6	-1.6	-0.5	-1.6
Locomotor testing rearing	1.2	1.9	4.3	2.1	-1.0	-0.1	-1.5
Light reinforcement 1	1.3	2.3	5.0	0.9	2.2	-1.2	1.4
Light reinforcement 2	1.1	1.4	2.8	-0.7	1.4	-0.7	1.7
Reaction time number correct	1.1	1.5	4.6	-2.2	-1.1	0.4	0.2
Reaction time mean minus median	0.5	0.7	1.3	1.0	-1.2	-0.6	-0.5
Reaction time mean minus median AUC	0.3	0.4	0.5	0.7	-0.7	-0.4	-0.5
Reaction time num false alarms	0.5	0.7	1.6	0.4	-0.3	1.0	-1.3
Reaction time num false alarms AUC	0.6	0.9	1.8	0.5	-0.1	1.2	-1.3
Reaction time trials correct on left	1.1	1.5	4.6	-2.2	-1.1	0.4	0.2
Reaction time trials on left	1.0	1.4	4.4	-2.1	-1.1	0.5	0.2
Reaction time mean	0.8	1.1	1.4	1.0	-1.2	0.9	-1.2
Reaction time mean AUC	1.0	1.3	2.0	0.9	-1.4	1.0	-1.3
Median of all reaction times	0.9	1.2	1.8	0.9	-0.9	1.3	-1.1
Reaction time omissions	0.3	0.4	1.0	1.0	0.4	0.3	0.4
Reaction time false alarm rate	0.6	0.8	1.8	1.3	0.6	0.4	-1.0
Reaction time premature initiation rate	1.0	1.3	4.2	-0.8	-0.6	-0.2	2.0
Reaction time premature initiations	1.6	2.2	4.0	-1.9	-1.1	0.1	2.0
Std. dev. reaction times	0.6	0.8	2.1	0.7	-1.4	0.2	-0.7
Reaction time trials completed	1.0	1.4	4.4	-2.1	-1.1	0.5	0.2
Reaction time trials AUC	1.1	1.6	4.6	-2.2	-1.2	0.5	0.1
Social response proportion	1.9	2.1	3.5	-1.9	-1.2	1.7	0.9
Social responses	0.8	1.1	3.5	-0.3	-0.4	1.9	0.8
Social time	0.7	0.9	1.8	1.1	0.1	1.3	-0.6
Conditioned locomotion	0.2	0.2	0.5	-0.5	0.0	0.0	0.7
Cocaine response after cond. corrected	1.1	1.3	4.0	-2.0	-0.6	0.2	0.8
Cocaine response after cond. not corrected	0.3	0.4	1.3	-1.1	-0.2	0.2	0.2
Cocaine response before conditioning	1.6	2.0	5.2	2.3	1.3	-0.5	-0.9
Saline control response	1.5	1.9	5.6	0.6	1.1	-2.4	0.8
Condit. Reinf. active minus inactive responses	0.3	0.4	0.9	0.6	0.5	-0.1	1.0
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.1	0.3	0.5	-0.1
Condit. Reinf. active responses	0.4	0.5	0.8	0.9	0.8	-0.3	0.7
Condit. Reinf. inactive responses	1.0	1.2	1.4	1.1	1.1	-1.2	0.9
Condit. Reinf. lever presses	1.1	1.6	4.9	2.2	0.5	0.5	-0.9
Condit. Reinf. lever reinforcers received	0.4	0.6	1.2	1.1	1.0	-0.3	0.5
Pavlov. Cond. lever latency	0.8	1.1	2.3	-1.5	0.3	-0.6	1.3
Pavlov. Cond. magazine entry latency	1.1	1.3	2.6	1.6	0.0	-0.1	-1.6
Pavlov. Cond. change in total contacts	1.3	1.8	2.9	0.1	-1.7	1.4	-1.5
Pavlov. Cond. index score	1.1	1.4	3.0	1.4	-0.7	0.4	-1.7
Pavlov. Cond. latency score	1.2	1.5	2.7	1.6	-0.7	0.5	-1.6
Pavlov. Cond. lever contacts	1.1	1.6	3.0	1.7	-0.6	0.5	-1.7
Pavlov. Cond. magazine entry number	0.9	1.1	2.2	-1.5	-0.0	-0.4	1.5
Pavlov. Cond. intertrial magazine entries	2.0	2.5	6.0	1.4	2.4	-1.0	1.2
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	3.1	1.3	-0.8	0.7	-1.8
Pavlov. Cond. response bias	1.4	1.9	4.4	1.6	-0.7	0.3	-2.1
Conditioned reinforcement - actives	0.4	0.4	1.3	-1.1	-0.2	0.2	0.5
Conditioned reinforcement - inactives	1.0	1.2	2.3	1.5	1.1	-0.9	0.5
Conditioned locomotion	0.5	0.6	1.1	0.3	-0.8	0.7	-1.1
Intermittent access intake day 1-15 change	3.0	3.0	3.8	1.2	2.0	-1.7	1.9
Intermittent access intake escalation	3.2	3.2	4.5	0.8	1.9	-2.1	2.0
Intermittent access intake escalation 2	0.6	0.6	1.6	0.4	0.6	-0.3	1.2
Intermitt. access day 1 inactive lever presses	1.8	2.0	4.3	0.7	1.0	-1.5	2.1
Intermitt. access day 15 inactive lever presses	1.1	1.2	1.5	1.1	1.2	-1.1	1.0
Intermitt. access escalation Index	0.4	0.4	0.7	-0.9	-0.5	-0.6	-0.4
Intermittent access day 1 total infusions	1.7	2.0	5.8	0.5	1.3	-2.4	0.4
Intermittent access day 15 total infusions	3.1	3.5	6.6	0.8	1.9	-2.6	1.7
Intermittent access terminal intake (last 3 days)	1.6	1.8	4.0	0.4	1.2	-2.0	1.2
Intermittent access total infusions	3.2	3.5	8.3	0.7	1.8	-2.9	1.4
Intermittent access day 1 locomotion	2.6	2.6	5.5	1.4	1.6	-2.3	0.7
Intermittent access day 15 total locomotion	1.1	1.2	2.3	0.4	1.5	-1.2	1.0
Intermittent access total locomotion	1.9	2.1	3.9	1.1	1.6	-2.0	0.8
Intermittent access standard deviation	2.0	2.1	5.8	0.1	0.8	-2.4	1.4
Cocaine induced anxiety	1.4	1.6	2.4	0.9	-1.6	1.3	-1.3
Post-drug Anxiety	0.6	0.6	1.3	1.2	0.1	0.6	0.9
Baseline Anxiety	2.1	2.2	3.7	0.6	1.9	-1.5	1.6
Lifetime Intake	2.3	2.6	6.9	0.6	1.4	-2.6	1.0
Incentive Sensitization - Responses	0.8	0.8	2.5	0.4	1.6	-0.6	0.1
Incentive Sensitization - Breakpoint	1.0	1.0	3.2	0.7	1.8	-0.6	0.2
Progressive ratio test 1 active lever presses	1.2	1.3	3.6	-0.6	0.7	-1.9	0.8
Progressive ratio test 1 breakpoint	1.3	1.3	3.3	-0.7	0.8	-1.8	0.9
Progressive ratio test 1 inactive lever presses	5.6	6.0	9.3	0.6	2.5	-3.0	2.8
Progressive ratio test 2 active lever presses	1.7	1.9	3.3	-0.5	1.8	-1.7	1.0
Progressive ratio test 2 breakpoint	2.1	2.3	4.6	-0.0	2.1	-1.9	0.9
Progressive ratio test 2 inactive lever presses	1.9	2.2	3.6	0.8	1.9	-1.9	1.1
Total sessions with >9 infusions	0.1	0.1	0.1	0.4	0.1	-0.2	0.3
Short access day 1 total inactive lever presses	4.4	4.9	11.2	1.3	2.5	-3.3	0.7
Short access day 10 total inactive lever presses	1.2	1.4	2.6	0.5	0.9	-1.3	1.6
Short access day 1 total infusions	0.4	0.5	1.6	-0.2	-0.0	-1.3	0.4
Short access day 10 total infusions	1.3	1.5	4.9	0.8	0.5	-2.2	-0.4
Short access total infusions	1.6	1.8	5.1	0.7	1.1	-2.3	0.7
Short access day 1 locomotion	0.5	0.5	0.9	0.9	-1.0	0.1	-0.5
Short access day 10 total locomotion	0.8	0.9	2.1	1.4	0.2	0.7	-0.9
Short access total locomotion	1.0	1.0	3.6	1.9	0.4	-0.5	0.2
Compulsive drug intake	0.8	0.8	1.9	0.8	0.6	-1.4	-0.2
One hour access (0.3 mA shock)	1.8	2.1	7.0	0.1	1.0	-2.6	0.7
One hour access (shock baseline)	0.5	0.5	1.1	-0.9	-0.3	-1.1	0.4
Number of responses in last shaping day	0.2	0.2	0.5	-0.3	-0.2	0.4	-0.7
Context. condit. distance diff. score	1.5	1.8	2.9	-0.9	1.7	-1.1	1.6
Locomotion velocity, session 1	0.9	1.0	1.5	-0.6	-1.1	0.9	-1.2
Locomotion distance, session 1	0.4	0.5	1.6	0.6	-0.2	0.1	-1.3
Locomotion velocity, session 2	0.3	0.4	0.8	0.5	-0.2	0.6	-0.9
Locomotion distance, session 2	1.0	1.4	4.9	0.8	-0.4	-0.1	-2.2
Locomotion velocity, session 3	0.2	0.2	0.3	-0.5	0.5	0.4	0.2
Locomotion distance, session 3	0.5	0.5	1.4	-0.2	1.2	-0.4	0.6
Stereotopy head waving bouts, day 3	0.7	0.8	1.3	-0.8	-1.2	1.2	0.0
Stereotopy head waving duration, day 3	0.7	0.9	2.1	-0.6	-1.4	0.7	-0.8
Locomotion velocity, session 7	3.5	3.8	10.1	-0.2	3.2	-0.8	2.1
Locomotion distance, session 7	1.8	2.3	6.3	-0.5	2.5	-0.6	1.5
Stereotopy head waving bouts, day 7	0.3	0.4	0.8	0.5	-0.2	0.9	-0.7
Stereotopy head waving duration, day 7	0.2	0.3	0.6	0.0	-0.8	0.8	-0.1
Locomotion velocity, session 8	0.3	0.3	0.7	-0.3	0.9	-0.7	0.2
Locomotion distance, session 8	0.7	1.0	2.4	0.5	1.5	-1.1	-0.4
Degree of sensitization distance	0.5	0.6	1.4	-0.4	1.2	-0.1	0.8
Degree of sensitization stereotypy	0.1	0.1	0.3	0.5	0.2	-0.1	0.1
Condit. Reinf. active minus inactive responses	0.4	0.5	1.5	1.2	0.2	-0.1	0.6
Condit. Reinf. active-inactive response ratio	0.8	0.8	1.7	-0.5	-1.2	1.3	0.3
Condit. Reinf. active responses	1.6	1.9	4.5	2.1	1.3	-1.0	0.6
Condit. Reinf. inactive responses	4.0	4.7	7.6	2.8	2.3	-2.4	0.3
Incentive salience index mean	2.1	2.5	7.6	2.8	1.2	-0.6	0.7
Condit. Reinf. lever presses	3.8	5.1	13.5	3.7	2.2	-1.2	0.9
Time in familiar zone, hab. session 1	0.6	0.5	1.8	0.6	1.4	-0.1	0.1
Time in novel zone, hab. session 1	2.5	2.5	5.9	-2.4	-1.9	0.4	0.0
Total zone transitions, hab. session 1	0.3	0.4	1.2	-0.0	-0.5	0.4	-1.1
Total locomotion distance, hab. session 1	0.5	0.7	1.3	0.9	-0.1	0.7	-1.2
Locomotion velocity, hab. session 1	0.9	1.3	2.8	1.7	0.0	0.2	-1.6
Time in familiar zone, hab. session 2	0.9	1.0	2.4	-1.6	-1.1	-0.4	-0.0
Time in novel zone, hab. session 2	0.2	0.2	0.4	0.4	0.6	0.4	-0.3
Total zone transitions, hab. session 2	0.6	0.7	1.6	0.2	-1.3	-0.1	-1.1
Total locomotion distance, hab. session 2	0.2	0.3	0.6	0.3	-0.6	-0.2	-0.8
Locomotion velocity, hab. session 2	0.5	0.6	1.5	0.4	-0.9	-0.0	-1.2
Novel to familiar place preference ratio	0.7	0.7	1.2	0.9	1.1	-0.6	0.5
Novelty place preference	0.8	0.9	1.5	1.0	1.2	-0.8	0.6
Time in novel zone, NPP test	0.5	0.5	1.0	0.8	1.0	-0.6	0.3
Total zone transitions, NPP test	0.3	0.5	1.1	0.8	0.0	-1.0	-0.5
Total locomotion distance, NPP test	0.7	1.0	2.0	1.4	0.8	-1.1	-0.3
Locomotion velocity, NPP test	1.0	1.4	2.5	1.6	1.0	-1.5	0.1
Pavlov. Cond. lever latency	2.3	3.0	4.8	-2.2	-1.6	1.7	-1.3
Pavlov. Cond. magazine entry latency	0.9	1.1	1.3	1.0	1.2	-1.0	1.1
Pavlov. Cond. change in total contacts	1.3	1.4	2.2	1.3	0.9	-1.5	0.8
Pavlov. Cond. index score	2.3	3.0	4.1	2.0	1.7	-1.8	1.3
Pavlov. Cond. latency score	2.7	3.4	5.3	2.3	1.9	-1.7	1.4
Pavlov. Cond. lever contacts	2.6	3.0	4.9	2.2	1.6	-1.8	1.3
Pavlov. Cond. magazine entry number	0.3	0.4	0.8	-0.5	-0.6	0.9	-0.4
Pavlov. Cond. intertrial magazine entries	0.7	0.9	3.1	1.7	0.5	-0.3	0.1
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.3	3.4	1.8	1.4	-1.7	0.9
Pavlov. Cond. response bias	0.8	1.0	1.3	1.1	0.8	-1.2	0.9
Bone: apparent density	0.3	0.5	1.4	0.6	0.5	-0.2	-1.2
Bone surface	0.4	0.7	2.3	0.7	-0.1	-0.1	-1.5
Bone volume	0.5	0.9	3.3	0.4	0.1	-0.3	-1.8
Bone: connectivity density	0.5	0.8	1.2	1.1	0.8	-1.0	0.7
Bone: cortical apparent density	1.0	1.3	3.5	-1.4	-0.1	-0.1	1.9
Bone: cortical area	0.3	0.5	1.8	0.0	-0.4	0.4	-1.3
Bone: cortical porosity	1.0	1.0	3.1	1.8	0.1	-0.7	-0.8
Bone: cortical porosity	0.9	1.0	2.5	1.6	-0.1	-0.4	-1.1
Bone: cortical thickness	0.2	0.3	0.6	0.3	0.5	-0.8	0.3
Bone: cortical thickness	0.2	0.3	0.4	-0.6	0.7	-0.3	0.5
Bone: cortical tissue density	1.1	1.4	3.6	-1.4	-0.1	-0.1	1.9
Bone: elastic displacement	0.2	0.2	0.7	0.4	-0.1	-0.8	0.1
Bone: elastic work	0.7	0.9	2.4	1.0	-0.2	-0.3	-1.5
Bone: endosteal estimation	1.1	2.4	5.3	0.1	-0.8	1.9	-2.3
Bone: endosteal perimeter	1.4	2.9	5.2	0.2	-1.2	2.3	-2.2
Bone: final force	0.4	0.6	1.3	1.1	1.1	0.0	-0.3
Bone: final moment	0.4	0.6	1.6	1.2	0.7	0.1	-0.6
Bone: marrow area	1.1	2.3	5.2	0.3	-0.7	1.9	-2.3
Bone: maximum diameter	0.9	1.7	2.5	-0.8	-1.0	1.6	-1.6
Bone: maximum force	0.4	0.8	2.0	0.8	0.4	0.5	-1.4
Bone: maximum moment	0.6	1.0	2.5	1.0	0.2	0.6	-1.6
Bone: minimum diameter	0.8	1.4	3.9	0.7	-0.7	0.8	-2.0
Bone: periosteal estimation	0.9	1.9	4.4	0.0	-0.7	1.6	-2.1
Bone: periosteal perimeter	0.7	1.1	2.3	-0.1	-0.7	1.3	-1.5
Bone: post-yield work	0.2	0.3	1.0	-0.1	1.0	0.2	-0.2
Bone: stiffness	0.3	0.5	0.9	1.0	0.6	0.4	-0.7
Bone: tissue strength	0.8	0.8	1.4	1.0	0.3	1.2	-0.8
Bone: trabecular number	0.4	0.6	1.1	1.0	1.1	-0.4	-0.4
Bone: trabecular spacing	0.5	0.7	1.1	-0.9	-1.0	0.9	-0.3
Bone: trabecular thickness	0.9	1.1	2.2	0.8	1.1	-1.5	-0.5
Bone: trabecular tissue density	0.7	1.0	1.7	-1.0	-1.3	0.8	-0.9
Breakpoint value in progressive ratio session	1.4	1.6	3.7	-1.3	0.0	-1.9	0.8
Distance traveled before self-admin	2.0	2.2	3.9	-0.6	-2.0	1.3	-1.6
Distance traveled after self-admin	3.1	3.5	5.8	-2.1	-2.4	1.6	-1.1
Delta time in closed arm before/after self-admin	1.3	1.2	3.1	0.6	-0.3	1.8	-1.2
Delta time in open arm before/after self-admin	0.2	0.1	0.5	0.2	0.7	-0.1	-0.0
Diff in mean of infusions in LGA sessions	2.6	2.9	5.7	-1.8	0.2	-2.4	1.6
Extinction: sum of active levers before priming	1.4	1.4	2.5	0.2	1.6	-1.5	0.9
Active lever presses in extinction session 6	1.0	1.0	1.7	0.0	1.3	-0.8	1.2
Delta distance traveled before/after self-admin	1.1	1.2	4.1	-2.0	-0.7	0.1	0.5
Delta ambulatory time before/after self-admin	0.7	0.7	2.2	-1.5	-0.6	-0.3	0.5
Time in closed arm before self-admin	0.2	0.2	0.5	0.1	-0.7	0.6	-0.3
Time in closed arm after self-admin	0.3	0.4	0.8	-0.1	-0.9	0.7	-0.4
Time in open arm before self-admin	0.4	0.4	1.1	-1.1	-0.5	-0.4	-0.2
Time in open arm after self-admin	0.1	0.1	0.3	-0.3	0.3	0.3	-0.5
Sum of active levers in priming session hrs 5-6	1.3	1.3	4.4	-2.1	-0.5	0.6	0.5
Time to tail flick, vehicle, before self-admin	4.5	4.5	8.1	1.1	2.3	-2.8	1.9
Time to tail flick, vehicle, after self-admin	2.2	2.4	3.3	-1.8	-0.1	-1.8	1.7
Time to tail flick, test, before self-admin	0.7	0.7	1.5	1.0	0.4	0.1	-1.2
Time to tail flick, test, after self-admin	1.1	1.1	1.8	1.0	1.3	-0.5	1.2
Delta time to tail flick, vehicle, before/after SA	1.1	1.1	3.1	-1.8	-0.8	-0.4	0.7
Delta time to tail flick, test, before/after SA	0.5	0.5	1.5	-0.3	0.5	0.2	1.2
Ambulatory time before self-admin	0.6	0.7	1.4	-0.4	-1.0	0.1	-1.2
Ambulatory time after self-admin	2.5	2.8	5.9	-1.8	-2.4	0.8	-1.2
Total heroin consumption	0.6	0.8	2.1	-0.9	-0.4	-1.4	-0.1
Area under the delay curve	0.5	0.6	1.6	0.7	-0.3	-0.2	-1.3
Delay disc. indifference point, 0s delay	0.9	1.0	1.7	0.8	-0.8	1.3	-0.9
Delay disc. indifference point, 16s delay	0.4	0.4	0.8	0.2	-0.5	-0.8	-0.9
Delay disc. indifference point, 2s delay	3.5	3.9	6.9	-0.2	-2.0	2.6	-2.1
Delay disc. indifference point, 24s delay	0.2	0.2	0.5	-0.2	-0.4	0.1	-0.7
Delay disc. indifference point, 4s delay	1.0	1.0	1.4	-0.2	-1.1	1.1	-1.2
Delay disc. indifference point, 8s delay	0.7	0.8	1.8	0.9	0.7	-1.3	-0.2
Delay discount exponential model param	0.6	0.7	2.0	-0.7	0.4	-0.0	1.4
Delay discount hyperbolic model param	0.9	1.0	2.8	-0.5	0.8	-0.5	1.7
Fecal boli incidents, locomotor time 1	1.6	1.7	5.7	0.1	-0.1	-2.4	-1.1
Change in fecal boli incidents, locomotor task	1.4	1.4	4.2	-0.5	-0.7	2.0	0.8
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.6	1.3	0.4	-0.6	0.1
Bouts of movement, locomotor time 1	0.7	0.8	1.5	-1.2	-0.8	-0.7	0.6
Total resting periods, locomotor time 1	0.8	0.9	2.0	-1.4	-1.0	-0.5	0.5
Rest time, locomotor task time 1	1.3	1.4	2.1	-1.3	-1.4	0.3	-1.3
Distance moved, locomotor task time 1	1.0	1.1	2.3	1.0	1.1	0.2	1.5
Vertical activity count, locomotor time 1	0.2	0.2	0.9	0.0	-1.0	0.1	0.1
Time >=10cm from walls, locomotor time 2	1.0	1.0	2.4	-0.6	-1.5	0.8	-0.8
Bouts of movement, locomotor time 2	1.0	1.1	2.9	-1.7	-0.5	-1.1	0.4
Total resting periods, locomotor time 2	1.2	1.3	2.6	-1.6	-0.4	-1.5	0.3
Rest time, locomotor task time 2	0.9	1.1	2.4	-1.2	0.3	-1.6	-0.5
Distance moved, locomotor task time 2	0.6	0.7	1.9	1.4	0.4	0.2	0.7
Vertical activity count, locomotor time 2	0.8	0.9	2.3	-0.4	-1.5	0.6	-1.0
Weight adjusted by age	2.0	2.2	5.3	-0.0	-1.8	2.3	-0.6
Seeking ratio, delayed vs. immediate footshock	0.8	1.0	2.4	0.8	-0.2	1.5	0.9
Locomotion in novel chamber	0.9	1.1	2.0	0.7	0.3	-1.4	-1.3
Locomotion in novel chamber post-restriction	0.8	1.0	2.3	-0.6	-0.0	1.5	-1.1
Progressive ratio	1.1	1.3	2.6	-1.3	0.3	-1.6	0.8
Food seeking constrained by brief footshock	4.5	5.5	14.8	-3.8	-1.6	-1.5	1.6
Seeking ratio, punishment vs. effort	0.9	1.2	2.7	-0.6	-1.2	1.6	-0.2
Run reversals in cocaine runway, females	0.2	0.2	0.4	0.2	0.6	0.4	-0.6
Run reversals in cocaine runway, males	1.1	1.0	3.2	-0.1	-0.2	-1.8	-0.9
Latency to leave start box in cocaine runway	1.1	1.2	2.1	-1.0	-1.5	1.1	-0.6
Latency to leave start box in cocaine runway, F	0.3	0.3	0.7	-0.7	-0.8	0.3	-0.1
Latency to leave start box in cocaine runway, M	0.3	0.2	0.4	-0.1	-0.6	0.5	-0.6
Cd content in liver	0.4	0.4	1.0	-0.1	0.7	-0.4	1.0
Co content in liver	2.9	3.4	9.3	-3.1	-1.7	0.9	-0.9
Cu content in liver	0.7	0.9	2.1	-1.4	-1.2	0.4	-0.1
Fe content in liver	0.2	0.3	0.5	0.7	0.6	0.2	0.4
K content in liver	0.5	0.5	1.0	0.6	1.0	-0.6	0.5
Mg content in liver	0.1	0.1	0.2	-0.3	0.2	0.0	-0.4
Mn content in liver	0.3	0.3	0.7	-0.4	-0.1	0.7	-0.8
Na content in liver	2.2	2.4	4.5	1.7	-1.1	0.9	-2.1
Rb content in liver	0.8	0.9	2.7	-0.1	0.7	-0.7	1.6
Se content in liver	1.3	1.5	2.5	0.5	-1.6	1.2	-1.4
Sr content in liver	0.8	0.7	1.5	-0.1	-0.5	1.2	-1.0
Zn content in liver	0.7	0.7	1.5	0.7	-0.9	0.1	-1.2