Hub : Genes

Mea1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression ENSRNOG00000017144 0.13 0.13 1.1e-03 0.06 0.06 0.07 0.07 2.9e-04 4.8e-04 8.4e-05 1.2e-04
2 LHb intron excision ratio chr9:14301586:14301993 0.16 0.11 8.7e-03 0.01 0.05 -0.01 0 1.6e-01 2.5e-02 5.3e-01 2.7e-01
3 Liver mRNA stability ENSRNOG00000017144 0.06 0.04 1.9e-08 0.07 0.06 0.06 0.06 6.4e-08 2.6e-07 9.5e-08 2.1e-07
4 OFC alternative TSS ENSRNOT00000089168 0.18 0.14 8.4e-03 0.02 0.03 0.02 0.01 1.4e-01 5.5e-02 8.7e-02 1.7e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
BMI with tail2.88.914.7-1.81.8-3.8-3.8
BMI without tail8.517.726.5-3.33.0-5.1-4.9
Body weight2.29.413.1-2.92.5-3.6-3.1
Epididymis fat weight2.25.28.6-2.92.5-2.2-1.1
Glucose4.06.18.5-2.42.4-2.9-2.1
Heart weight1.11.62.31.3-1.51.30.7
Left kidney weight0.41.02.90.2-1.0-0.6-1.7
Right kidney weight0.51.32.21.0-1.50.1-1.4
Tail length1.75.07.6-2.82.0-2.3-1.8
Length with tail0.20.82.6-1.60.6-0.4-0.1
Length without tail1.73.86.31.0-1.42.52.4
Liver weight, left0.40.61.90.1-0.3-0.7-1.4
Liver weight, right0.60.91.7-1.30.8-0.9-0.7
Parametrial fat weight4.99.512.7-3.22.9-3.6-2.7
Retroperitoneal fat weight1.13.88.7-1.00.5-2.3-3.0
Intraocular pressure1.11.53.51.9-1.01.00.7
Extensor digitorum longus weight0.10.20.6-0.20.1-0.6-0.7
Soleus weight0.31.01.5-1.20.7-1.1-1.0
Tibialis anterior weight0.10.50.7-0.70.8-0.8-0.5
Tibia length1.54.29.2-1.00.9-2.5-3.0
Number of licking bursts4.04.87.4-2.62.7-2.1-0.7
Food consumed during 24 hour testing period0.50.61.80.3-0.2-0.7-1.3
Times rat made contact with spout4.14.66.0-2.12.4-2.4-1.5
Mean time between licks in bursts1.11.64.20.60.01.32.0
Mean num. licks in bursts0.91.12.21.5-1.30.8-0.1
Std. dev. time between licks in bursts1.51.82.31.5-1.21.41.1
Water consumed over 24 hours1.51.84.2-0.90.4-1.5-2.0
Indifference point 0 sec0.60.91.3-0.80.9-1.1-0.9
Indifference point AUC1.31.54.40.6-0.8-0.7-2.1
Indifference point function ln k0.40.61.21.1-0.60.70.6
Indifference point function log k0.40.61.21.1-0.60.70.6
Delay discounting total patch changes 0 sec0.71.21.7-0.80.9-1.3-1.1
Delay discounting total patch changes 12 sec0.91.13.4-0.4-0.2-0.9-1.9
Delay discounting total patch changes 18 sec1.11.44.1-0.3-0.0-1.2-2.0
Delay discounting total patch changes 24 sec0.60.82.1-0.40.1-0.9-1.4
Delay discounting total patch changes 6 sec1.52.33.3-1.51.0-1.7-1.8
Delay discounting time to switch 0 sec3.25.012.30.4-0.52.73.5
Delay discounting water rate 0 sec2.94.613.70.5-0.9-1.9-3.7
Delay discounting water rate 12 sec3.65.510.8-1.21.1-2.9-3.3
Delay discounting water rate 18 sec0.81.12.8-0.30.3-1.2-1.7
Delay discounting water rate 24 sec1.31.84.5-0.10.4-1.7-2.1
Delay discounting water rate 6 sec0.81.12.41.0-0.9-0.5-1.6
Locomotor activity2.33.66.0-2.42.0-1.9-1.1
Locomotor testing distance2.13.46.0-2.41.9-1.8-0.9
Locomotor testing rearing2.13.45.9-1.31.0-2.2-2.4
Light reinforcement 11.42.64.3-1.20.9-2.0-2.1
Light reinforcement 22.83.75.0-2.22.2-2.1-0.9
Reaction time number correct0.81.22.21.3-1.50.4-0.8
Reaction time mean minus median0.10.20.3-0.5-0.10.50.5
Reaction time mean minus median AUC0.40.51.2-0.40.10.81.1
Reaction time num false alarms0.40.60.90.6-0.61.00.9
Reaction time num false alarms AUC0.30.50.70.6-0.70.80.6
Reaction time trials correct on left0.81.22.21.3-1.50.4-0.8
Reaction time trials on left0.71.01.91.2-1.40.3-0.8
Reaction time mean1.41.93.0-1.61.40.21.7
Reaction time mean AUC1.62.13.2-1.71.60.11.8
Median of all reaction times1.42.02.7-1.61.6-0.11.6
Reaction time omissions0.60.91.7-1.31.0-0.9-0.3
Reaction time false alarm rate0.50.61.7-0.0-0.00.91.3
Reaction time premature initiation rate0.81.01.6-0.90.8-1.3-1.0
Reaction time premature initiations0.71.02.6-0.2-0.0-1.1-1.6
Std. dev. reaction times0.91.32.3-1.50.90.41.4
Reaction time trials completed0.71.01.91.2-1.40.3-0.8
Reaction time trials AUC0.71.01.71.1-1.30.2-1.0
Social response proportion0.60.61.40.0-0.40.91.2
Social responses1.21.62.60.2-1.11.61.6
Social time2.63.47.12.1-2.71.3-0.3
Conditioned locomotion2.53.04.92.2-2.21.50.2
Cocaine response after cond. corrected0.20.20.30.5-0.30.50.5
Cocaine response after cond. not corrected0.40.40.60.8-0.60.70.5
Cocaine response before conditioning0.20.20.50.3-0.5-0.2-0.7
Saline control response0.00.00.1-0.1-0.30.1-0.2
Condit. Reinf. active minus inactive responses0.30.40.7-0.70.8-0.00.6
Condit. Reinf. active-inactive response ratio1.31.42.9-1.41.7-0.90.1
Condit. Reinf. active responses0.00.10.1-0.30.30.10.3
Condit. Reinf. inactive responses0.20.20.50.5-0.70.3-0.3
Condit. Reinf. lever presses0.71.01.9-1.41.2-0.8-0.1
Condit. Reinf. lever reinforcers received0.10.10.1-0.30.30.10.3
Pavlov. Cond. lever latency2.83.96.92.6-2.11.90.8
Pavlov. Cond. magazine entry latency2.02.33.9-2.01.4-1.6-0.8
Pavlov. Cond. change in total contacts2.94.07.6-2.82.1-1.8-0.8
Pavlov. Cond. index score4.45.89.2-3.02.3-2.5-1.5
Pavlov. Cond. latency score4.86.19.5-3.12.4-2.6-1.5
Pavlov. Cond. lever contacts3.14.27.6-2.82.1-2.0-1.0
Pavlov. Cond. magazine entry number1.21.43.31.8-1.01.10.4
Pavlov. Cond. intertrial magazine entries0.10.10.40.7-0.20.1-0.2
Pavlov. Cond. lever-magazine prob. diff.4.55.99.7-3.12.4-2.5-1.4
Pavlov. Cond. response bias1.62.25.1-2.31.5-1.1-0.2
Conditioned reinforcement - actives1.21.22.71.1-1.60.9-0.1
Conditioned reinforcement - inactives0.70.82.2-0.2-0.2-1.0-1.5
Conditioned locomotion0.00.00.1-0.2-0.1-0.1-0.1
Intermittent access intake day 1-15 change0.20.20.4-0.4-0.5-0.2-0.7
Intermittent access intake escalation0.10.10.1-0.4-0.3-0.0-0.2
Intermittent access intake escalation 20.20.20.6-0.1-0.5-0.2-0.8
Intermitt. access day 1 inactive lever presses1.01.12.1-0.70.8-1.5-1.1
Intermitt. access day 15 inactive lever presses1.41.53.0-0.70.8-1.7-1.4
Intermitt. access escalation Index0.10.10.20.40.1-0.00.2
Intermittent access day 1 total infusions0.80.91.4-1.01.2-1.1-0.2
Intermittent access day 15 total infusions0.50.60.9-0.90.7-0.9-0.2
Intermittent access terminal intake (last 3 days)0.50.50.9-0.90.8-0.70.1
Intermittent access total infusions0.40.50.7-0.80.8-0.70.3
Intermittent access day 1 locomotion0.50.51.4-0.31.2-0.70.3
Intermittent access day 15 total locomotion0.20.30.5-0.30.5-0.7-0.4
Intermittent access total locomotion0.40.51.1-0.41.0-0.40.7
Intermittent access standard deviation2.02.25.20.2-0.51.82.3
Cocaine induced anxiety0.20.20.4-0.50.6-0.40.1
Post-drug Anxiety0.50.51.0-1.00.7-0.10.7
Baseline Anxiety0.10.10.2-0.1-0.30.40.5
Lifetime Intake0.10.10.3-0.20.2-0.10.5
Incentive Sensitization - Responses1.01.01.9-0.60.2-1.3-1.4
Incentive Sensitization - Breakpoint1.01.02.0-0.60.2-1.3-1.4
Progressive ratio test 1 active lever presses1.51.62.4-1.51.6-1.3-0.2
Progressive ratio test 1 breakpoint1.11.21.6-1.21.2-1.2-0.4
Progressive ratio test 1 inactive lever presses0.80.81.6-0.60.4-1.3-1.1
Progressive ratio test 2 active lever presses1.01.11.9-0.80.5-1.4-1.2
Progressive ratio test 2 breakpoint1.41.62.7-0.90.6-1.7-1.5
Progressive ratio test 2 inactive lever presses0.50.51.1-0.50.2-1.0-0.9
Total sessions with >9 infusions0.10.10.10.2-0.4-0.1-0.2
Short access day 1 total inactive lever presses0.30.40.80.5-0.6-0.3-0.9
Short access day 10 total inactive lever presses0.80.92.20.0-0.1-1.1-1.5
Short access day 1 total infusions0.30.40.70.7-0.80.50.2
Short access day 10 total infusions0.40.40.7-0.70.8-0.40.7
Short access total infusions0.20.20.70.3-0.10.40.9
Short access day 1 locomotion0.40.40.60.5-0.50.70.8
Short access day 10 total locomotion1.71.85.00.6-0.01.42.2
Short access total locomotion1.71.82.11.5-1.01.41.4
Compulsive drug intake0.60.60.91.0-0.90.4-0.6
One hour access (0.3 mA shock)0.60.71.60.9-1.30.6-0.3
One hour access (shock baseline)0.30.30.5-0.70.6-0.6-0.1
Number of responses in last shaping day0.20.20.50.2-0.3-0.3-0.7
Context. condit. distance diff. score0.40.41.2-1.10.6-0.4-0.0
Locomotion velocity, session 10.80.92.50.4-0.6-0.7-1.6
Locomotion distance, session 11.72.23.1-1.41.0-1.8-1.6
Locomotion velocity, session 23.94.69.0-1.60.9-2.5-3.0
Locomotion distance, session 21.01.42.6-0.70.5-1.5-1.6
Locomotion velocity, session 30.70.82.30.4-0.6-0.5-1.5
Locomotion distance, session 31.11.22.01.4-1.41.00.2
Stereotopy head waving bouts, day 30.81.01.6-0.71.0-1.3-1.1
Stereotopy head waving duration, day 31.31.53.1-0.40.7-1.5-1.8
Locomotion velocity, session 70.60.71.60.6-0.8-0.4-1.3
Locomotion distance, session 70.40.51.00.7-0.7-0.3-1.0
Stereotopy head waving bouts, day 70.30.30.7-0.80.6-0.5-0.2
Stereotopy head waving duration, day 70.30.40.5-0.70.60.20.7
Locomotion velocity, session 80.40.50.8-0.80.4-0.7-0.9
Locomotion distance, session 80.91.31.8-1.30.8-1.3-1.1
Degree of sensitization distance1.31.32.3-0.70.6-1.5-1.5
Degree of sensitization stereotypy0.40.41.0-0.40.00.71.0
Condit. Reinf. active minus inactive responses1.21.31.9-0.91.0-1.4-1.2
Condit. Reinf. active-inactive response ratio0.30.30.6-0.60.8-0.5-0.2
Condit. Reinf. active responses2.12.63.5-1.61.4-1.9-1.6
Condit. Reinf. inactive responses1.82.12.8-1.51.3-1.7-1.3
Incentive salience index mean1.51.93.3-1.10.7-1.6-1.8
Condit. Reinf. lever presses2.83.85.9-1.81.1-2.2-2.4
Time in familiar zone, hab. session 10.90.82.30.2-0.6-0.8-1.5
Time in novel zone, hab. session 10.70.71.40.6-0.00.91.2
Total zone transitions, hab. session 13.24.56.9-1.91.6-2.6-2.2
Total locomotion distance, hab. session 13.04.47.4-1.51.1-2.5-2.7
Locomotion velocity, hab. session 12.73.96.7-1.51.0-2.4-2.6
Time in familiar zone, hab. session 21.31.43.40.2-0.41.41.8
Time in novel zone, hab. session 20.40.41.10.5-0.2-0.6-1.1
Total zone transitions, hab. session 23.14.16.1-2.42.5-2.0-0.7
Total locomotion distance, hab. session 22.63.54.7-1.92.0-2.2-1.3
Locomotion velocity, hab. session 22.22.93.8-1.81.9-1.9-1.1
Novel to familiar place preference ratio0.10.10.1-0.20.2-0.3-0.3
Novelty place preference0.00.00.0-0.1-0.0-0.0-0.2
Time in novel zone, NPP test0.00.00.00.1-0.1-0.0-0.2
Total zone transitions, NPP test5.68.010.6-3.02.5-3.3-2.5
Total locomotion distance, NPP test4.96.88.9-2.72.4-3.0-2.2
Locomotion velocity, NPP test5.88.211.1-3.32.7-3.1-2.1
Pavlov. Cond. lever latency1.92.45.21.1-0.21.72.3
Pavlov. Cond. magazine entry latency1.01.33.70.4-0.8-0.9-1.9
Pavlov. Cond. change in total contacts1.51.64.1-0.40.1-1.5-2.0
Pavlov. Cond. index score2.02.66.8-0.8-0.1-1.7-2.6
Pavlov. Cond. latency score1.62.05.7-0.5-0.4-1.4-2.4
Pavlov. Cond. lever contacts2.63.16.1-1.40.5-2.0-2.5
Pavlov. Cond. magazine entry number1.51.95.10.50.21.52.3
Pavlov. Cond. intertrial magazine entries0.60.71.30.6-0.41.11.1
Pavlov. Cond. lever-magazine prob. diff.1.92.46.6-0.6-0.2-1.7-2.6
Pavlov. Cond. response bias3.03.78.0-1.20.5-2.3-2.8
Bone: apparent density0.50.92.3-0.60.60.71.5
Bone surface0.91.64.50.1-0.11.42.1
Bone volume0.40.72.1-0.10.10.91.4
Bone: connectivity density1.11.74.8-0.50.80.92.2
Bone: cortical apparent density0.50.71.30.5-1.01.10.6
Bone: cortical area0.60.82.3-0.5-0.3-0.8-1.5
Bone: cortical porosity0.10.10.2-0.10.4-0.4-0.1
Bone: cortical porosity0.10.10.20.5-0.1-0.3-0.4
Bone: cortical thickness0.81.33.4-0.7-0.2-1.1-1.8
Bone: cortical thickness0.10.10.1-0.30.30.00.4
Bone: cortical tissue density0.50.61.10.4-0.91.10.6
Bone: elastic displacement0.20.20.50.2-0.40.70.5
Bone: elastic work0.20.30.9-1.00.5-0.00.2
Bone: endosteal estimation0.30.61.20.5-0.40.91.1
Bone: endosteal perimeter0.00.00.0-0.00.00.00.0
Bone: final force0.40.61.2-1.10.5-0.8-0.7
Bone: final moment0.30.50.9-0.70.1-0.7-1.0
Bone: marrow area0.30.71.30.5-0.41.01.1
Bone: maximum diameter0.30.51.50.3-0.6-0.5-1.2
Bone: maximum force0.20.41.1-1.10.7-0.20.4
Bone: maximum moment0.10.10.4-0.60.2-0.10.1
Bone: minimum diameter0.20.30.6-0.20.1-0.7-0.8
Bone: periosteal estimation0.10.20.40.1-0.4-0.2-0.6
Bone: periosteal perimeter0.50.81.1-1.00.4-1.0-1.0
Bone: post-yield work0.20.30.5-0.50.7-0.20.6
Bone: stiffness0.10.10.2-0.40.30.00.4
Bone: tissue strength0.10.10.20.1-0.40.40.1
Bone: trabecular number0.40.61.7-0.30.10.71.3
Bone: trabecular spacing0.60.82.30.4-0.4-0.7-1.5
Bone: trabecular thickness0.60.82.30.00.20.91.5
Bone: trabecular tissue density1.72.34.52.1-1.80.3-1.2
Breakpoint value in progressive ratio session0.10.10.30.0-0.50.2-0.4
Distance traveled before self-admin0.10.10.40.2-0.1-0.4-0.6
Distance traveled after self-admin2.32.64.4-0.51.3-2.1-2.0
Delta time in closed arm before/after self-admin0.60.61.2-1.10.9-0.50.3
Delta time in open arm before/after self-admin1.01.02.91.7-0.80.60.1
Diff in mean of infusions in LGA sessions0.60.61.6-0.6-0.4-0.6-1.3
Extinction: sum of active levers before priming0.00.00.10.2-0.1-0.0-0.2
Active lever presses in extinction session 60.40.41.00.1-0.8-0.0-1.0
Delta distance traveled before/after self-admin3.23.45.1-1.22.1-2.3-1.6
Delta ambulatory time before/after self-admin2.52.74.0-1.01.9-2.0-1.5
Time in closed arm before self-admin0.30.31.0-0.00.50.21.0
Time in closed arm after self-admin0.91.01.7-0.91.3-0.21.2
Time in open arm before self-admin2.12.34.8-1.20.3-1.6-2.2
Time in open arm after self-admin0.80.92.40.7-0.5-0.6-1.5
Sum of active levers in priming session hrs 5-61.91.94.11.5-2.00.9-0.5
Time to tail flick, vehicle, before self-admin0.20.20.4-0.6-0.40.30.5
Time to tail flick, vehicle, after self-admin2.12.25.6-0.5-0.01.72.4
Time to tail flick, test, before self-admin5.15.07.32.5-2.72.40.9
Time to tail flick, test, after self-admin0.40.41.10.1-0.61.10.6
Delta time to tail flick, vehicle, before/after SA0.50.51.00.2-0.01.01.0
Delta time to tail flick, test, before/after SA3.53.26.4-2.52.3-0.90.4
Ambulatory time before self-admin0.30.30.50.6-0.70.2-0.4
Ambulatory time after self-admin2.12.43.6-0.81.3-1.9-1.9
Total heroin consumption0.10.10.3-0.60.3-0.3-0.1
Area under the delay curve7.47.911.62.8-3.03.41.7
Delay disc. indifference point, 0s delay2.22.45.12.2-1.31.50.5
Delay disc. indifference point, 16s delay9.19.213.52.7-3.33.72.3
Delay disc. indifference point, 2s delay3.64.05.72.4-2.02.30.8
Delay disc. indifference point, 24s delay0.90.91.80.4-0.71.31.1
Delay disc. indifference point, 4s delay4.54.88.62.4-2.92.2-0.1
Delay disc. indifference point, 8s delay4.85.07.12.3-2.52.71.1
Delay discount exponential model param7.17.511.6-2.63.0-3.4-1.7
Delay discount hyperbolic model param6.77.110.7-2.62.9-3.3-1.5
Fecal boli incidents, locomotor time 11.11.12.41.3-1.60.5-0.4
Change in fecal boli incidents, locomotor task0.20.20.50.3-0.70.3-0.3
Time >=10cm from walls, locomotor time 10.40.41.00.3-0.2-0.6-1.0
Bouts of movement, locomotor time 10.50.50.91.00.7-0.00.9
Total resting periods, locomotor time 10.40.41.00.51.0-0.50.3
Rest time, locomotor task time 10.80.91.91.4-1.00.80.4
Distance moved, locomotor task time 10.10.10.2-0.50.40.00.1
Vertical activity count, locomotor time 10.50.51.20.2-0.61.10.7
Time >=10cm from walls, locomotor time 20.60.61.90.4-0.4-0.6-1.4
Bouts of movement, locomotor time 20.40.50.9-1.00.6-0.6-0.3
Total resting periods, locomotor time 20.30.30.7-0.90.6-0.30.1
Rest time, locomotor task time 20.50.51.30.4-0.10.81.1
Distance moved, locomotor task time 20.60.71.2-0.20.8-1.1-0.9
Vertical activity count, locomotor time 20.30.30.60.5-0.70.5-0.2
Weight adjusted by age0.20.20.4-0.50.1-0.2-0.6
Seeking ratio, delayed vs. immediate footshock1.41.62.90.8-0.71.51.7
Locomotion in novel chamber0.60.71.00.8-1.01.00.6
Locomotion in novel chamber post-restriction1.82.14.51.7-2.11.1-0.0
Progressive ratio0.40.51.0-0.2-0.61.00.7
Food seeking constrained by brief footshock0.10.10.3-0.60.5-0.10.1
Seeking ratio, punishment vs. effort0.40.40.90.00.6-0.9-0.8
Run reversals in cocaine runway, females0.60.61.5-0.7-0.1-0.7-1.2
Run reversals in cocaine runway, males0.20.20.20.4-0.2-0.4-0.5
Latency to leave start box in cocaine runway1.31.52.7-0.40.5-1.6-1.6
Latency to leave start box in cocaine runway, F0.20.20.40.10.5-0.6-0.2
Latency to leave start box in cocaine runway, M3.53.47.0-1.10.6-2.3-2.6
Cd content in liver1.61.73.81.9-1.41.10.3
Co content in liver0.10.10.20.40.1-0.2-0.2
Cu content in liver1.21.52.61.6-1.61.0-0.2
Fe content in liver0.20.30.5-0.2-0.50.60.7
K content in liver1.51.53.5-0.91.10.61.9
Mg content in liver1.31.32.30.5-0.91.51.4
Mn content in liver0.60.61.3-0.21.2-1.0-0.5
Na content in liver0.20.20.6-0.8-0.1-0.1-0.3
Rb content in liver4.55.68.61.8-2.32.92.3
Se content in liver0.20.30.60.6-0.3-0.3-0.8
Sr content in liver0.50.51.20.10.2-0.9-1.1
Zn content in liver5.56.09.63.1-3.02.20.8