Hub : Genes

Tbc1d22a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000017057	0.1	0.07	1.2e-11	0.07	0.07	0.08	0.08	1.2e-08	1.4e-08	5.4e-09	9.3e-09
2	Adipose	mRNA stability	ENSRNOG00000017057	0.04	0.02	4.0e-05	0.03	0.03	0.03	0.02	4.3e-04	3.8e-04	8.1e-04	1.5e-03
3	Liver	gene expression	ENSRNOG00000017057	0.15	0.07	0.0e+00	0.16	0.16	0.16	0.16	5.6e-18	3.3e-17	7.8e-17	1.3e-17

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
BMI with tail	3.6	11.8	12.5	3.4	-3.4	-3.5
BMI without tail	1.3	2.8	3.4	1.7	-1.8	-1.4
Body weight	3.0	12.5	13.0	3.6	-3.6	-3.4
Epididymis fat weight	0.7	1.5	1.8	1.2	-1.1	-1.4
Glucose	0.0	0.0	0.0	-0.0	0.1	-0.2
Heart weight	0.3	0.4	0.4	-0.6	0.6	0.6
Left kidney weight	13.0	37.3	39.1	6.1	-6.2	-5.9
Right kidney weight	13.0	37.0	37.4	6.1	-6.1	-6.0
Tail length	0.3	0.8	1.6	-0.7	0.5	1.3
Length with tail	0.4	1.5	1.8	1.3	-1.3	-1.1
Length without tail	2.2	4.9	6.3	2.2	-1.9	-2.5
Liver weight, left	0.4	0.6	0.8	0.8	-0.7	-0.9
Liver weight, right	0.8	1.4	1.6	1.3	-1.2	-1.1
Parametrial fat weight	0.3	0.7	1.1	-0.7	0.6	1.0
Retroperitoneal fat weight	3.2	10.5	10.9	3.3	-3.2	-3.2
Intraocular pressure	0.8	1.2	1.3	1.2	-1.0	-1.0
Extensor digitorum longus weight	0.6	2.3	2.6	1.6	-1.5	-1.5
Soleus weight	0.3	0.8	1.0	0.9	-0.8	-1.0
Tibialis anterior weight	0.1	0.4	0.5	-0.6	0.7	0.7
Tibia length	0.3	0.7	0.8	0.8	-0.9	-0.9
Number of licking bursts	0.2	0.3	0.3	-0.5	0.5	0.6
Food consumed during 24 hour testing period	5.1	6.1	6.7	2.5	-2.6	-2.4
Times rat made contact with spout	0.4	0.4	0.5	0.7	-0.7	-0.5
Mean time between licks in bursts	1.4	1.9	2.5	-1.3	1.2	1.6
Mean num. licks in bursts	1.4	1.7	1.8	1.3	-1.3	-1.3
Std. dev. time between licks in bursts	0.1	0.1	0.2	-0.4	0.4	0.3
Water consumed over 24 hours	2.3	2.7	3.0	1.6	-1.7	-1.6
Indifference point 0 sec	0.0	0.0	0.0	-0.0	0.0	-0.0
Indifference point AUC	0.4	0.5	0.6	-0.8	0.6	0.7
Indifference point function ln k	4.0	5.6	5.8	2.4	-2.3	-2.4
Indifference point function log k	4.0	5.6	5.8	2.4	-2.3	-2.4
Delay discounting total patch changes 0 sec	0.1	0.1	0.1	-0.3	0.3	0.3
Delay discounting total patch changes 12 sec	0.0	0.0	0.0	-0.1	0.0	0.2
Delay discounting total patch changes 18 sec	0.6	0.8	0.8	-0.9	0.8	0.9
Delay discounting total patch changes 24 sec	0.1	0.1	0.2	-0.3	0.3	0.4
Delay discounting total patch changes 6 sec	0.7	1.0	1.1	-1.1	1.0	1.0
Delay discounting time to switch 0 sec	0.3	0.5	0.6	-0.6	0.7	0.8
Delay discounting water rate 0 sec	0.3	0.5	0.7	0.6	-0.8	-0.7
Delay discounting water rate 12 sec	0.8	1.2	1.4	1.1	-1.1	-1.2
Delay discounting water rate 18 sec	0.1	0.1	0.2	0.2	-0.4	-0.2
Delay discounting water rate 24 sec	0.9	1.2	1.5	1.0	-1.0	-1.2
Delay discounting water rate 6 sec	0.0	0.0	0.0	-0.0	0.0	0.0
Locomotor activity	3.6	5.6	6.1	2.5	-2.5	-2.2
Locomotor testing distance	0.5	0.9	1.0	1.0	-1.0	-0.8
Locomotor testing rearing	0.8	1.3	1.5	1.2	-1.2	-0.9
Light reinforcement 1	0.3	0.6	1.0	0.8	-1.0	-0.4
Light reinforcement 2	4.4	5.8	6.1	2.4	-2.5	-2.4
Reaction time number correct	0.3	0.5	0.5	-0.7	0.6	0.7
Reaction time mean minus median	0.2	0.3	0.4	-0.5	0.6	0.4
Reaction time mean minus median AUC	0.1	0.1	0.2	-0.3	0.4	0.3
Reaction time num false alarms	0.0	0.0	0.1	0.2	-0.3	-0.1
Reaction time num false alarms AUC	0.0	0.1	0.1	0.3	-0.3	-0.1
Reaction time trials correct on left	0.3	0.5	0.5	-0.7	0.6	0.7
Reaction time trials on left	0.4	0.5	0.6	-0.7	0.7	0.8
Reaction time mean	2.1	2.9	3.5	-1.8	1.9	1.5
Reaction time mean AUC	2.6	3.5	4.0	-1.9	2.0	1.7
Median of all reaction times	2.7	3.7	4.3	-2.0	2.1	1.7
Reaction time omissions	1.6	2.1	2.5	-1.6	1.5	1.3
Reaction time false alarm rate	0.3	0.4	0.5	0.6	-0.7	-0.6
Reaction time premature initiation rate	0.2	0.3	0.6	0.5	-0.4	-0.7
Reaction time premature initiations	0.0	0.0	0.0	-0.0	0.1	-0.1
Std. dev. reaction times	0.8	1.2	1.4	-1.1	1.2	0.9
Reaction time trials completed	0.4	0.5	0.6	-0.7	0.7	0.8
Reaction time trials AUC	0.1	0.2	0.2	-0.4	0.4	0.5
Social response proportion	1.7	1.9	2.0	1.4	-1.3	-1.4
Social responses	1.4	1.8	2.2	1.4	-1.5	-1.1
Social time	0.1	0.1	0.1	-0.3	0.2	0.3
Conditioned locomotion	0.1	0.1	0.1	0.3	-0.2	-0.3
Cocaine response after cond. corrected	0.5	0.6	0.6	0.8	-0.7	-0.8
Cocaine response after cond. not corrected	0.2	0.2	0.2	0.5	-0.5	-0.4
Cocaine response before conditioning	0.4	0.5	0.7	-0.7	0.6	0.8
Saline control response	0.4	0.5	0.6	0.7	-0.7	-0.8
Condit. Reinf. active minus inactive responses	0.5	0.6	0.6	0.7	-0.8	-0.8
Condit. Reinf. active-inactive response ratio	0.0	0.1	0.1	0.2	-0.3	-0.2
Condit. Reinf. active responses	1.7	2.3	2.4	1.5	-1.6	-1.5
Condit. Reinf. inactive responses	3.0	3.7	3.8	1.9	-2.0	-1.9
Condit. Reinf. lever presses	0.4	0.6	0.8	0.7	-0.9	-0.6
Condit. Reinf. lever reinforcers received	1.1	1.6	1.6	1.2	-1.3	-1.3
Pavlov. Cond. lever latency	0.1	0.2	0.3	-0.4	0.5	0.4
Pavlov. Cond. magazine entry latency	1.1	1.2	1.7	-1.2	1.3	0.8
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	-0.1	0.0	-0.1
Pavlov. Cond. index score	0.1	0.1	0.1	-0.4	0.3	0.2
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.3	0.2	0.1
Pavlov. Cond. lever contacts	0.3	0.4	0.4	0.6	-0.6	-0.6
Pavlov. Cond. magazine entry number	0.5	0.6	0.7	0.8	-0.8	-0.6
Pavlov. Cond. intertrial magazine entries	0.9	1.1	1.4	1.0	-1.0	-1.2
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.2	-0.4	0.4	0.3
Pavlov. Cond. response bias	0.0	0.0	0.0	-0.0	-0.0	-0.1
Conditioned reinforcement - actives	0.1	0.1	0.1	0.3	-0.2	-0.2
Conditioned reinforcement - inactives	1.4	1.6	2.1	1.2	-1.1	-1.4
Conditioned locomotion	2.5	3.0	3.4	1.7	-1.8	-1.6
Intermittent access intake day 1-15 change	0.7	0.7	0.9	0.8	-0.7	-1.0
Intermittent access intake escalation	1.6	1.6	1.8	1.3	-1.1	-1.4
Intermittent access intake escalation 2	0.3	0.3	0.5	0.4	-0.3	-0.7
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.3	0.4	-0.3	-0.6
Intermitt. access day 15 inactive lever presses	3.2	3.5	3.8	1.9	-1.8	-2.0
Intermitt. access escalation Index	0.6	0.6	0.6	0.8	-0.7	-0.8
Intermittent access day 1 total infusions	3.9	4.4	4.6	2.1	-2.1	-2.1
Intermittent access day 15 total infusions	5.4	6.1	6.7	2.5	-2.3	-2.6
Intermittent access terminal intake (last 3 days)	8.4	9.1	10.2	3.0	-2.8	-3.2
Intermittent access total infusions	7.2	8.0	9.0	2.8	-2.7	-3.0
Intermittent access day 1 locomotion	1.9	1.9	2.1	1.4	-1.3	-1.4
Intermittent access day 15 total locomotion	3.9	4.2	4.5	2.1	-2.1	-1.9
Intermittent access total locomotion	4.4	4.9	5.2	2.2	-2.1	-2.3
Intermittent access standard deviation	1.5	1.6	2.3	1.1	-1.0	-1.5
Cocaine induced anxiety	1.9	2.2	3.0	1.4	-1.3	-1.7
Post-drug Anxiety	0.9	1.0	1.7	0.9	-0.7	-1.3
Baseline Anxiety	0.9	1.0	1.0	-0.9	1.0	1.0
Lifetime Intake	6.9	7.7	8.2	2.8	-2.7	-2.9
Incentive Sensitization - Responses	0.5	0.5	0.8	0.6	-0.6	-0.9
Incentive Sensitization - Breakpoint	0.6	0.6	0.9	0.7	-0.6	-0.9
Progressive ratio test 1 active lever presses	2.0	2.0	2.1	1.5	-1.4	-1.4
Progressive ratio test 1 breakpoint	1.8	1.9	2.0	1.4	-1.4	-1.3
Progressive ratio test 1 inactive lever presses	0.6	0.6	0.7	0.8	-0.7	-0.8
Progressive ratio test 2 active lever presses	1.0	1.1	1.5	1.0	-0.8	-1.2
Progressive ratio test 2 breakpoint	0.8	0.9	1.4	0.9	-0.8	-1.2
Progressive ratio test 2 inactive lever presses	2.6	3.1	4.1	1.7	-1.5	-2.0
Total sessions with >9 infusions	4.0	4.4	4.9	2.1	-2.2	-2.0
Short access day 1 total inactive lever presses	4.2	4.7	4.9	2.2	-2.2	-2.1
Short access day 10 total inactive lever presses	0.4	0.4	0.5	0.7	-0.6	-0.6
Short access day 1 total infusions	2.5	2.6	3.0	1.7	-1.7	-1.4
Short access day 10 total infusions	6.1	6.7	6.9	2.6	-2.5	-2.6
Short access total infusions	7.4	8.2	8.3	2.9	-2.9	-2.8
Short access day 1 locomotion	0.2	0.2	0.3	0.4	-0.5	-0.5
Short access day 10 total locomotion	0.2	0.2	0.4	0.6	-0.6	-0.2
Short access total locomotion	2.5	2.6	2.8	1.6	-1.7	-1.6
Compulsive drug intake	1.1	1.1	1.1	-1.1	1.1	1.1
One hour access (0.3 mA shock)	1.7	1.9	2.3	1.4	-1.2	-1.5
One hour access (shock baseline)	4.0	4.6	5.2	2.2	-2.0	-2.3
Number of responses in last shaping day	0.0	0.0	0.0	-0.0	-0.1	0.2
Context. condit. distance diff. score	1.1	1.3	1.4	1.2	-1.2	-1.1
Locomotion velocity, session 1	1.0	1.1	1.5	1.1	-1.2	-0.8
Locomotion distance, session 1	0.4	0.6	0.9	-0.7	0.6	0.9
Locomotion velocity, session 2	3.6	4.2	4.6	2.1	-2.1	-1.9
Locomotion distance, session 2	0.1	0.2	0.2	-0.5	0.5	0.4
Locomotion velocity, session 3	1.4	1.7	2.1	1.4	-1.4	-1.0
Locomotion distance, session 3	0.0	0.0	0.0	0.1	-0.1	0.1
Stereotopy head waving bouts, day 3	0.3	0.3	0.6	0.6	-0.7	-0.4
Stereotopy head waving duration, day 3	0.9	1.1	1.6	1.1	-1.3	-0.8
Locomotion velocity, session 7	0.7	0.8	1.1	1.0	-1.0	-0.6
Locomotion distance, session 7	0.3	0.3	0.4	0.6	-0.6	-0.6
Stereotopy head waving bouts, day 7	0.9	1.0	1.2	1.0	-1.1	-0.8
Stereotopy head waving duration, day 7	0.3	0.3	0.4	0.6	-0.6	-0.4
Locomotion velocity, session 8	6.1	7.3	7.4	2.7	-2.7	-2.7
Locomotion distance, session 8	0.5	0.8	0.8	0.9	-0.9	-0.8
Degree of sensitization distance	1.4	1.4	1.7	1.2	-1.1	-1.3
Degree of sensitization stereotypy	0.5	0.6	0.7	0.8	-0.8	-0.7
Condit. Reinf. active minus inactive responses	0.2	0.3	0.4	-0.6	0.4	0.4
Condit. Reinf. active-inactive response ratio	1.3	1.4	1.7	-1.3	1.2	1.1
Condit. Reinf. active responses	0.7	0.8	1.0	-1.0	0.8	0.9
Condit. Reinf. inactive responses	0.1	0.1	0.1	-0.2	0.2	0.4
Incentive salience index mean	0.1	0.1	0.2	0.2	-0.4	-0.2
Condit. Reinf. lever presses	1.0	1.3	1.8	1.1	-1.3	-1.0
Time in familiar zone, hab. session 1	1.5	1.4	1.6	1.3	-1.2	-1.1
Time in novel zone, hab. session 1	0.3	0.3	0.3	-0.6	0.4	0.5
Total zone transitions, hab. session 1	2.4	3.4	3.4	-1.8	1.8	1.8
Total locomotion distance, hab. session 1	0.1	0.1	0.2	-0.3	0.2	0.5
Locomotion velocity, hab. session 1	0.1	0.1	0.2	-0.3	0.2	0.5
Time in familiar zone, hab. session 2	0.2	0.2	0.2	0.4	-0.5	-0.2
Time in novel zone, hab. session 2	0.7	0.7	0.8	-0.9	0.9	0.7
Total zone transitions, hab. session 2	0.1	0.1	0.1	0.3	-0.3	-0.4
Total locomotion distance, hab. session 2	0.1	0.1	0.1	0.3	-0.3	-0.2
Locomotion velocity, hab. session 2	0.0	0.0	0.1	0.2	-0.3	-0.1
Novel to familiar place preference ratio	0.8	0.8	1.0	-0.9	0.8	1.0
Novelty place preference	0.4	0.4	0.6	-0.6	0.5	0.8
Time in novel zone, NPP test	0.5	0.6	0.8	-0.7	0.6	0.9
Total zone transitions, NPP test	0.9	1.3	1.5	-1.1	1.2	1.1
Total locomotion distance, NPP test	0.1	0.2	0.2	-0.4	0.4	0.4
Locomotion velocity, NPP test	0.1	0.2	0.2	-0.4	0.4	0.5
Pavlov. Cond. lever latency	0.8	1.0	1.1	-0.9	1.1	1.0
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	-0.1	0.1	-0.0
Pavlov. Cond. change in total contacts	0.2	0.2	0.3	0.4	-0.5	-0.6
Pavlov. Cond. index score	0.3	0.3	0.4	0.5	-0.6	-0.7
Pavlov. Cond. latency score	0.5	0.6	0.7	0.7	-0.8	-0.8
Pavlov. Cond. lever contacts	1.6	1.9	2.1	1.3	-1.4	-1.3
Pavlov. Cond. magazine entry number	0.0	0.1	0.1	-0.2	0.2	0.3
Pavlov. Cond. intertrial magazine entries	0.7	0.8	0.9	-0.9	1.0	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.2	0.3	-0.4	-0.5
Pavlov. Cond. response bias	0.7	0.9	1.0	0.9	-0.9	-1.0
Bone: apparent density	0.5	0.9	1.0	-0.9	1.0	0.9
Bone surface	0.2	0.4	0.4	-0.6	0.7	0.7
Bone volume	0.5	0.8	0.9	-0.8	0.9	0.9
Bone: connectivity density	0.3	0.5	0.5	-0.7	0.7	0.7
Bone: cortical apparent density	1.4	1.8	2.0	-1.4	1.4	1.2
Bone: cortical area	1.7	2.5	2.7	1.5	-1.6	-1.6
Bone: cortical porosity	2.4	2.6	3.3	1.5	-1.5	-1.8
Bone: cortical porosity	2.1	2.2	2.9	1.4	-1.4	-1.7
Bone: cortical thickness	0.0	0.1	0.2	0.1	-0.0	-0.4
Bone: cortical thickness	2.1	2.4	3.1	1.5	-1.4	-1.8
Bone: cortical tissue density	1.1	1.4	1.6	-1.2	1.2	1.1
Bone: elastic displacement	0.5	0.5	0.6	0.8	-0.8	-0.6
Bone: elastic work	4.0	5.1	5.3	2.3	-2.3	-2.3
Bone: endosteal estimation	2.1	4.6	5.2	2.2	-2.3	-1.9
Bone: endosteal perimeter	3.6	7.3	7.9	2.8	-2.8	-2.5
Bone: final force	0.8	1.4	1.7	1.1	-1.1	-1.3
Bone: final moment	1.0	1.7	2.0	1.2	-1.2	-1.4
Bone: marrow area	2.1	4.6	5.2	2.2	-2.3	-2.0
Bone: maximum diameter	6.8	12.5	13.0	3.5	-3.6	-3.5
Bone: maximum force	1.0	1.8	2.2	1.3	-1.2	-1.5
Bone: maximum moment	1.2	2.1	2.6	1.4	-1.4	-1.6
Bone: minimum diameter	2.1	3.8	4.2	2.0	-2.0	-1.9
Bone: periosteal estimation	2.7	5.5	5.8	2.3	-2.4	-2.3
Bone: periosteal perimeter	4.8	8.0	8.7	2.8	-2.9	-2.7
Bone: post-yield work	0.9	1.2	1.3	-1.2	1.1	1.0
Bone: stiffness	0.1	0.1	0.3	-0.4	0.5	0.0
Bone: tissue strength	0.3	0.3	0.4	-0.5	0.6	0.4
Bone: trabecular number	0.5	0.8	0.8	-0.8	0.9	0.9
Bone: trabecular spacing	2.5	3.3	3.8	1.8	-1.9	-1.6
Bone: trabecular thickness	0.1	0.1	0.1	-0.3	0.4	0.2
Bone: trabecular tissue density	1.4	1.9	2.2	-1.4	1.5	1.3
Breakpoint value in progressive ratio session	0.0	0.0	0.1	-0.1	0.3	0.0
Distance traveled before self-admin	0.2	0.2	0.2	0.4	-0.5	-0.3
Distance traveled after self-admin	1.2	1.3	1.4	1.1	-1.1	-1.2
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	0.1	0.0	-0.2
Delta time in open arm before/after self-admin	0.1	0.1	0.3	-0.1	0.1	0.6
Diff in mean of infusions in LGA sessions	0.3	0.3	0.6	0.5	-0.4	-0.7
Extinction: sum of active levers before priming	0.1	0.1	0.1	-0.2	0.3	0.0
Active lever presses in extinction session 6	1.0	0.9	1.1	0.9	-0.9	-1.1
Delta distance traveled before/after self-admin	0.5	0.5	0.5	0.7	-0.7	-0.7
Delta ambulatory time before/after self-admin	0.4	0.4	0.4	0.7	-0.6	-0.6
Time in closed arm before self-admin	0.1	0.1	0.2	-0.3	0.5	-0.0
Time in closed arm after self-admin	0.1	0.1	0.2	0.3	-0.2	-0.5
Time in open arm before self-admin	0.4	0.4	0.7	-0.5	0.6	0.8
Time in open arm after self-admin	0.6	0.7	1.2	-0.7	0.7	1.1
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	0.1	-0.0	-0.1
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.2	-0.4	0.4	0.5
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.4	0.6	-0.7	-0.4
Time to tail flick, test, before self-admin	1.9	1.8	2.0	1.4	-1.4	-1.3
Time to tail flick, test, after self-admin	0.1	0.1	0.2	-0.0	-0.0	-0.5
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.5	0.7	-0.7	-0.7
Delta time to tail flick, test, before/after SA	1.8	1.6	2.0	-1.4	1.4	0.9
Ambulatory time before self-admin	0.0	0.0	0.1	0.2	-0.2	0.0
Ambulatory time after self-admin	0.2	0.3	0.3	0.5	-0.5	-0.6
Total heroin consumption	0.1	0.2	0.2	0.4	-0.4	-0.4
Area under the delay curve	5.6	6.0	6.2	-2.5	2.4	2.4
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	0.2	-0.1	-0.4
Delay disc. indifference point, 16s delay	5.6	5.6	6.1	-2.4	2.5	2.3
Delay disc. indifference point, 2s delay	0.8	0.9	1.0	-1.0	1.0	1.0
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	-0.3	0.2	0.2
Delay disc. indifference point, 4s delay	8.3	8.7	9.4	-3.1	2.8	2.9
Delay disc. indifference point, 8s delay	5.3	5.4	5.5	-2.4	2.3	2.3
Delay discount exponential model param	5.9	6.2	6.4	2.5	-2.5	-2.5
Delay discount hyperbolic model param	5.5	5.8	6.0	2.4	-2.4	-2.4
Fecal boli incidents, locomotor time 1	0.0	0.1	0.1	0.3	-0.2	-0.1
Change in fecal boli incidents, locomotor task	0.8	0.7	1.0	-0.9	0.6	1.0
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	0.0	-0.1	0.0
Bouts of movement, locomotor time 1	0.7	0.8	0.9	0.8	-0.8	-1.0
Total resting periods, locomotor time 1	0.2	0.2	0.3	0.4	-0.4	-0.6
Rest time, locomotor task time 1	0.3	0.3	0.4	0.5	-0.7	-0.5
Distance moved, locomotor task time 1	0.0	0.0	0.0	0.2	-0.2	0.0
Vertical activity count, locomotor time 1	0.1	0.1	0.1	-0.3	0.2	0.3
Time >=10cm from walls, locomotor time 2	0.5	0.5	0.7	0.5	-0.6	-0.9
Bouts of movement, locomotor time 2	1.0	1.1	1.3	-1.1	1.1	0.9
Total resting periods, locomotor time 2	1.0	1.1	1.4	-1.1	1.2	0.9
Rest time, locomotor task time 2	2.5	2.9	3.5	-1.6	1.6	1.9
Distance moved, locomotor task time 2	4.0	4.7	4.7	2.2	-2.2	-2.2
Vertical activity count, locomotor time 2	4.1	4.5	4.6	2.1	-2.1	-2.2
Weight adjusted by age	2.0	2.2	2.6	1.4	-1.5	-1.6
Seeking ratio, delayed vs. immediate footshock	1.1	1.3	1.5	-1.1	1.2	1.0
Locomotion in novel chamber	0.9	1.1	2.5	-0.8	0.6	1.6
Locomotion in novel chamber post-restriction	0.1	0.1	0.2	-0.1	0.1	0.5
Progressive ratio	0.5	0.6	0.9	-0.7	0.7	0.9
Food seeking constrained by brief footshock	1.0	1.2	1.6	1.1	-1.0	-1.2
Seeking ratio, punishment vs. effort	1.3	1.6	2.3	1.1	-1.1	-1.5
Run reversals in cocaine runway, females	0.4	0.4	0.8	-0.6	0.4	0.9
Run reversals in cocaine runway, males	0.2	0.2	0.3	0.4	-0.6	-0.1
Latency to leave start box in cocaine runway	2.1	2.3	2.6	1.5	-1.6	-1.4
Latency to leave start box in cocaine runway, F	1.1	1.2	1.2	1.1	-1.1	-1.1
Latency to leave start box in cocaine runway, M	2.0	1.9	2.2	1.4	-1.5	-1.3
Cd content in liver	0.1	0.1	0.2	-0.3	0.4	0.3
Co content in liver	0.7	0.8	1.1	0.9	-1.0	-0.7
Cu content in liver	8.4	10.1	10.4	-3.2	3.2	3.1
Fe content in liver	0.4	0.5	0.6	0.7	-0.6	-0.8
K content in liver	0.0	0.0	0.1	0.1	-0.0	-0.4
Mg content in liver	0.1	0.1	0.1	0.1	0.1	-0.4
Mn content in liver	1.4	1.6	1.7	1.3	-1.3	-1.2
Na content in liver	2.7	2.8	3.5	-1.7	1.9	1.4
Rb content in liver	0.6	0.8	0.8	-0.9	0.9	0.8
Se content in liver	0.0	0.0	0.0	0.1	-0.1	-0.0
Sr content in liver	2.6	2.4	3.6	-1.5	1.1	1.9
Zn content in liver	0.9	1.0	1.1	-1.0	1.0	1.1