Cerk

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000017022	0.19	0.09	0.0e+00	0.17	0.18	0.18	0.19	4.9e-19	5.1e-20	1.3e-19	2.7e-20
2	Brain	mRNA stability	ENSRNOG00000017022	0.05	0.04	3.8e-04	0.03	0.03	0.02	0.02	1.2e-03	1.0e-03	2.6e-03	6.2e-03
3	LHb	gene expression	ENSRNOG00000017022	0.15	0.1	3.4e-03	0.04	-0.01	0.06	0.02	3.3e-02	5.6e-01	1.3e-02	1.1e-01
4	Liver	intron excision ratio	chr7:117232430:117235358	0.03	0.02	8.1e-04	0.01	0.02	0.01	0.01	2.5e-02	3.6e-03	5.2e-02	1.2e-02
5	Liver	intron excision ratio	chr7:117235510:117237333	0.02	0.02	1.9e-03	0.01	0.02	0.01	0.01	4.2e-02	6.1e-03	3.4e-02	2.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
BMI with tail	3.1	10.2	12.2	3.2	2.6	3.5	3.4	-3.2
BMI without tail	1.5	3.2	5.1	1.9	2.3	0.8	1.8	-1.9
Body weight	2.8	11.7	13.8	3.5	3.7	2.3	3.6	-3.7
Epididymis fat weight	0.5	1.1	1.4	1.1	1.1	0.8	1.2	-1.2
Glucose	0.1	0.1	0.3	-0.2	-0.5	0.2	-0.0	0.1
Heart weight	0.4	0.6	1.1	-0.8	-1.1	-0.0	-0.8	0.9
Left kidney weight	12.0	34.3	38.2	6.1	5.5	5.3	6.2	-6.1
Right kidney weight	11.4	32.5	36.4	5.8	5.0	5.7	6.0	-5.9
Tail length	0.4	1.1	4.4	-0.4	0.9	-2.1	-0.4	0.2
Length with tail	0.5	2.0	3.9	1.2	2.0	-0.2	1.4	-1.6
Length without tail	1.5	3.3	4.2	1.8	1.2	2.1	2.0	-1.9
Liver weight, left	0.3	0.4	0.7	0.6	0.4	0.9	0.7	-0.6
Liver weight, right	1.1	1.9	4.1	1.2	2.0	-0.1	1.3	-1.5
Parametrial fat weight	0.3	0.5	1.5	-0.6	0.4	-1.2	-0.6	0.4
Retroperitoneal fat weight	2.9	9.7	11.1	3.2	3.3	2.3	3.3	-3.3
Intraocular pressure	1.0	1.4	2.9	1.1	1.7	0.0	1.1	-1.3
Extensor digitorum longus weight	0.4	1.8	2.1	1.5	1.3	0.9	1.4	-1.4
Soleus weight	0.3	0.7	1.5	0.9	0.4	1.2	0.8	-0.8
Tibialis anterior weight	0.2	0.5	0.8	-0.7	-0.9	-0.4	-0.8	0.8
Tibia length	0.2	0.7	0.8	0.7	0.7	0.9	0.9	-0.9
Number of licking bursts	0.3	0.4	1.5	-0.4	0.1	-1.2	-0.5	0.3
Food consumed during 24 hour testing period	4.6	5.5	6.6	2.4	2.1	2.1	2.6	-2.5
Times rat made contact with spout	0.6	0.6	1.3	0.8	1.1	-0.2	0.7	-0.8
Mean time between licks in bursts	1.1	1.5	2.9	-1.1	-0.7	-1.7	-1.2	1.2
Mean num. licks in bursts	1.3	1.5	2.5	1.2	0.8	1.6	1.3	-1.2
Std. dev. time between licks in bursts	0.2	0.2	0.6	-0.4	-0.8	0.2	-0.4	0.5
Water consumed over 24 hours	2.0	2.4	2.9	1.7	1.4	1.2	1.7	-1.7
Indifference point 0 sec	0.0	0.0	0.0	0.1	0.1	0.0	0.0	-0.0
Indifference point AUC	0.2	0.2	0.3	-0.5	-0.2	-0.4	-0.5	0.5
Indifference point function ln k	3.1	4.4	5.2	2.2	2.0	1.6	2.3	-2.3
Indifference point function log k	3.1	4.4	5.2	2.2	2.0	1.6	2.3	-2.3
Delay discounting total patch changes 0 sec	0.0	0.1	0.1	-0.2	-0.2	-0.3	-0.3	0.3
Delay discounting total patch changes 12 sec	0.0	0.0	0.0	-0.0	0.0	0.2	-0.0	0.0
Delay discounting total patch changes 18 sec	0.5	0.6	1.2	-0.7	-0.5	-1.1	-0.8	0.7
Delay discounting total patch changes 24 sec	0.0	0.1	0.2	-0.1	0.1	-0.4	-0.2	0.2
Delay discounting total patch changes 6 sec	0.4	0.7	0.9	-0.9	-0.7	-0.7	-0.9	0.9
Delay discounting time to switch 0 sec	0.4	0.6	1.0	-0.8	-1.0	-0.5	-0.8	0.8
Delay discounting water rate 0 sec	0.4	0.7	1.0	0.8	0.8	1.0	0.8	-0.8
Delay discounting water rate 12 sec	0.8	1.2	1.8	1.1	1.4	0.4	1.1	-1.2
Delay discounting water rate 18 sec	0.2	0.2	0.4	0.5	0.6	0.3	0.5	-0.5
Delay discounting water rate 24 sec	0.7	1.0	1.7	0.9	0.7	1.3	1.0	-1.0
Delay discounting water rate 6 sec	0.1	0.1	0.3	0.2	0.5	-0.6	0.1	-0.2
Locomotor activity	3.7	5.9	8.2	2.6	2.9	1.1	2.5	-2.6
Locomotor testing distance	0.7	1.1	1.8	1.2	1.3	0.2	1.0	-1.1
Locomotor testing rearing	1.0	1.5	2.3	1.4	1.5	0.3	1.2	-1.3
Light reinforcement 1	0.7	1.3	3.1	1.1	1.8	0.1	1.0	-1.1
Light reinforcement 2	4.4	5.8	6.4	2.4	2.5	2.0	2.5	-2.5
Reaction time number correct	0.3	0.4	0.8	-0.7	-0.3	-0.9	-0.6	0.5
Reaction time mean minus median	0.2	0.3	0.5	-0.5	-0.4	-0.7	-0.5	0.5
Reaction time mean minus median AUC	0.1	0.2	0.5	-0.3	0.1	-0.7	-0.4	0.3
Reaction time num false alarms	0.2	0.3	0.6	0.4	0.8	-0.6	0.3	-0.4
Reaction time num false alarms AUC	0.3	0.4	0.9	0.5	0.9	-0.7	0.4	-0.5
Reaction time trials correct on left	0.3	0.4	0.8	-0.7	-0.3	-0.9	-0.6	0.5
Reaction time trials on left	0.3	0.4	0.8	-0.7	-0.3	-0.9	-0.6	0.6
Reaction time mean	2.4	3.3	4.9	-1.9	-2.2	-0.8	-1.9	2.0
Reaction time mean AUC	2.7	3.7	5.1	-2.0	-2.3	-0.9	-2.0	2.1
Median of all reaction times	3.0	4.1	6.6	-2.0	-2.6	-0.7	-2.1	2.2
Reaction time omissions	1.5	2.0	2.5	-1.6	-1.5	-0.8	-1.5	1.5
Reaction time false alarm rate	0.4	0.6	1.0	0.9	1.0	-0.0	0.7	-0.8
Reaction time premature initiation rate	0.4	0.6	2.4	0.2	-0.6	1.5	0.4	-0.1
Reaction time premature initiations	0.2	0.3	0.7	-0.3	-0.9	0.8	-0.1	0.3
Std. dev. reaction times	0.8	1.2	1.3	-1.1	-1.1	-0.9	-1.2	1.1
Reaction time trials completed	0.3	0.4	0.8	-0.7	-0.3	-0.9	-0.6	0.6
Reaction time trials AUC	0.1	0.2	0.4	-0.4	-0.1	-0.6	-0.4	0.3
Social response proportion	1.3	1.4	1.8	1.2	1.0	1.0	1.3	-1.3
Social responses	1.7	2.2	3.5	1.5	1.9	0.5	1.5	-1.6
Social time	0.2	0.3	1.2	-0.1	0.4	-1.1	-0.2	0.0
Conditioned locomotion	0.0	0.1	0.1	0.3	0.3	0.1	0.2	-0.2
Cocaine response after cond. corrected	0.5	0.6	0.9	0.8	1.0	0.1	0.8	-0.8
Cocaine response after cond. not corrected	0.4	0.4	1.0	0.6	1.0	-0.4	0.5	-0.6
Cocaine response before conditioning	0.3	0.3	0.7	-0.6	-0.2	-0.8	-0.6	0.5
Saline control response	0.3	0.4	0.5	0.7	0.3	0.6	0.7	-0.6
Condit. Reinf. active minus inactive responses	0.4	0.5	1.1	0.5	0.4	1.0	0.8	-0.7
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.1	0.1	0.5	0.2	-0.2
Condit. Reinf. active responses	1.5	2.1	3.1	1.3	1.0	1.8	1.5	-1.4
Condit. Reinf. inactive responses	2.7	3.4	3.8	1.9	1.6	1.9	1.9	-1.9
Condit. Reinf. lever presses	0.5	0.7	1.0	0.8	0.8	1.0	0.9	-0.8
Condit. Reinf. lever reinforcers received	1.0	1.4	2.3	1.0	0.8	1.5	1.3	-1.2
Pavlov. Cond. lever latency	0.2	0.2	0.4	-0.4	-0.3	-0.6	-0.5	0.4
Pavlov. Cond. magazine entry latency	1.8	2.1	4.2	-1.4	-2.1	0.1	-1.3	1.5
Pavlov. Cond. change in total contacts	0.3	0.4	0.9	-0.3	-0.8	1.0	-0.1	0.2
Pavlov. Cond. index score	0.3	0.3	0.8	-0.5	-0.9	0.5	-0.4	0.5
Pavlov. Cond. latency score	0.3	0.3	0.7	-0.4	-0.9	0.7	-0.3	0.4
Pavlov. Cond. lever contacts	0.3	0.4	1.4	0.5	0.1	1.2	0.6	-0.5
Pavlov. Cond. magazine entry number	0.8	1.0	2.0	1.0	1.4	-0.1	0.9	-1.0
Pavlov. Cond. intertrial magazine entries	0.8	1.0	2.2	1.0	0.5	1.5	1.0	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.7	-0.6	-0.9	0.3	-0.5	0.6
Pavlov. Cond. response bias	0.1	0.2	0.6	-0.1	-0.5	0.8	-0.0	0.1
Conditioned reinforcement - actives	0.2	0.2	0.5	0.2	0.7	-0.3	0.3	-0.4
Conditioned reinforcement - inactives	0.9	1.0	1.2	1.1	0.8	0.9	1.1	-1.0
Conditioned locomotion	2.8	3.3	3.9	2.0	2.0	1.4	1.9	-1.9
Intermittent access intake day 1-15 change	0.3	0.3	0.5	0.6	0.2	0.6	0.7	-0.6
Intermittent access intake escalation	1.0	1.0	1.2	1.1	0.6	1.0	1.1	-1.1
Intermittent access intake escalation 2	0.1	0.1	0.3	0.2	-0.5	0.6	0.3	-0.2
Intermitt. access day 1 inactive lever presses	0.3	0.3	1.3	0.1	-0.4	1.2	0.3	-0.2
Intermitt. access day 15 inactive lever presses	3.0	3.3	6.6	1.7	1.0	2.6	1.8	-1.7
Intermitt. access escalation Index	0.4	0.4	0.6	0.8	0.6	0.5	0.7	-0.7
Intermittent access day 1 total infusions	3.6	4.1	5.5	2.1	2.3	1.3	2.1	-2.2
Intermittent access day 15 total infusions	4.1	4.6	5.5	2.3	2.1	1.7	2.3	-2.3
Intermittent access terminal intake (last 3 days)	6.3	6.9	8.1	2.8	2.4	2.2	2.8	-2.8
Intermittent access total infusions	5.6	6.2	7.3	2.6	2.4	2.0	2.7	-2.7
Intermittent access day 1 locomotion	2.0	2.0	3.3	1.4	1.8	0.6	1.4	-1.6
Intermittent access day 15 total locomotion	4.0	4.2	5.4	2.2	2.3	1.2	2.1	-2.2
Intermittent access total locomotion	3.8	4.2	4.9	2.2	2.0	1.7	2.2	-2.2
Intermittent access standard deviation	0.9	1.0	2.2	0.9	0.3	1.5	1.0	-0.9
Cocaine induced anxiety	1.6	1.9	4.8	1.2	0.5	2.2	1.3	-1.1
Post-drug Anxiety	1.0	1.1	4.1	0.6	-0.5	2.0	0.7	-0.5
Baseline Anxiety	1.0	1.0	1.2	-0.9	-1.1	-1.0	-1.0	1.0
Lifetime Intake	5.7	6.3	7.4	2.6	2.6	1.9	2.7	-2.7
Incentive Sensitization - Responses	0.7	0.7	2.6	0.4	-0.0	1.6	0.6	-0.5
Incentive Sensitization - Breakpoint	0.7	0.7	2.7	0.5	0.1	1.6	0.7	-0.5
Progressive ratio test 1 active lever presses	2.4	2.5	4.8	1.6	2.2	0.4	1.5	-1.7
Progressive ratio test 1 breakpoint	2.3	2.3	4.5	1.5	2.1	0.4	1.4	-1.6
Progressive ratio test 1 inactive lever presses	0.6	0.7	1.3	0.8	1.1	0.4	0.8	-0.9
Progressive ratio test 2 active lever presses	0.8	0.8	1.7	0.7	0.6	1.3	0.9	-0.9
Progressive ratio test 2 breakpoint	0.7	0.7	1.7	0.7	0.6	1.3	0.8	-0.8
Progressive ratio test 2 inactive lever presses	2.0	2.3	3.8	1.4	1.1	2.0	1.5	-1.5
Total sessions with >9 infusions	4.1	4.5	6.3	2.2	2.5	1.1	2.2	-2.3
Short access day 1 total inactive lever presses	3.9	4.4	4.7	2.1	2.1	1.9	2.2	-2.2
Short access day 10 total inactive lever presses	0.4	0.4	1.0	0.6	0.2	1.0	0.6	-0.6
Short access day 1 total infusions	2.6	2.8	4.2	1.6	2.1	0.8	1.7	-1.8
Short access day 10 total infusions	5.4	6.0	7.3	2.5	2.7	1.6	2.6	-2.6
Short access total infusions	6.8	7.5	8.6	2.7	2.9	2.1	2.9	-2.9
Short access day 1 locomotion	0.2	0.2	0.3	0.5	0.4	0.5	0.5	-0.5
Short access day 10 total locomotion	0.7	0.8	2.1	0.8	1.4	-0.4	0.6	-0.8
Short access total locomotion	2.4	2.5	2.9	1.5	1.7	1.3	1.7	-1.7
Compulsive drug intake	1.4	1.4	2.6	-1.2	-1.6	-0.3	-1.1	1.3
One hour access (0.3 mA shock)	1.2	1.4	1.6	1.1	1.2	0.9	1.2	-1.3
One hour access (shock baseline)	3.4	4.0	5.2	2.0	2.3	1.2	2.1	-2.2
Number of responses in last shaping day	0.0	0.0	0.0	0.0	0.2	-0.1	0.1	-0.1
Context. condit. distance diff. score	1.1	1.3	1.7	1.3	0.9	1.1	1.2	-1.1
Locomotion velocity, session 1	1.3	1.4	2.4	1.3	1.6	0.1	1.2	-1.3
Locomotion distance, session 1	0.4	0.5	1.8	-0.4	-0.1	-1.3	-0.6	0.5
Locomotion velocity, session 2	3.9	4.5	7.0	2.1	2.6	1.0	2.2	-2.3
Locomotion distance, session 2	0.2	0.3	0.4	-0.5	-0.6	-0.2	-0.5	0.6
Locomotion velocity, session 3	2.4	2.8	5.8	1.6	2.4	-0.4	1.5	-1.7
Locomotion distance, session 3	0.4	0.4	1.3	0.2	0.9	-1.1	0.1	-0.3
Stereotopy head waving bouts, day 3	0.4	0.5	0.7	0.8	0.8	0.4	0.7	-0.7
Stereotopy head waving duration, day 3	1.1	1.3	1.8	1.3	1.2	0.8	1.2	-1.2
Locomotion velocity, session 7	1.2	1.3	2.8	1.0	1.7	0.1	1.1	-1.2
Locomotion distance, session 7	0.3	0.4	0.9	0.6	0.9	0.2	0.6	-0.7
Stereotopy head waving bouts, day 7	0.9	1.1	1.5	1.1	1.2	0.4	1.1	-1.1
Stereotopy head waving duration, day 7	0.3	0.4	0.6	0.7	0.8	0.2	0.6	-0.7
Locomotion velocity, session 8	5.3	6.3	7.1	2.7	2.2	2.4	2.7	-2.6
Locomotion distance, session 8	0.6	0.8	1.1	1.0	1.0	0.7	0.9	-1.0
Degree of sensitization distance	1.3	1.4	3.4	1.0	0.5	1.8	1.1	-1.0
Degree of sensitization stereotypy	0.5	0.5	0.7	0.8	0.8	0.3	0.8	-0.8
Condit. Reinf. active minus inactive responses	0.2	0.2	0.4	-0.6	-0.3	-0.3	-0.4	0.4
Condit. Reinf. active-inactive response ratio	1.2	1.3	1.7	-1.3	-1.1	-0.9	-1.1	1.1
Condit. Reinf. active responses	0.5	0.5	1.0	-0.9	-0.2	-1.0	-0.7	0.6
Condit. Reinf. inactive responses	0.1	0.1	0.5	-0.1	0.4	-0.7	-0.1	0.0
Incentive salience index mean	0.2	0.3	0.7	0.3	0.9	-0.1	0.5	-0.6
Condit. Reinf. lever presses	1.6	2.1	4.1	1.4	2.0	0.2	1.4	-1.6
Time in familiar zone, hab. session 1	1.2	1.1	1.4	1.2	1.0	0.8	1.1	-1.1
Time in novel zone, hab. session 1	0.3	0.2	0.4	-0.6	-0.6	-0.3	-0.5	0.5
Total zone transitions, hab. session 1	2.2	3.1	3.5	-1.8	-1.8	-1.5	-1.9	1.9
Total locomotion distance, hab. session 1	0.1	0.1	0.3	-0.1	0.1	-0.6	-0.2	0.2
Locomotion velocity, hab. session 1	0.1	0.1	0.4	-0.0	0.3	-0.6	-0.2	0.1
Time in familiar zone, hab. session 2	0.3	0.3	0.8	0.6	0.9	-0.1	0.5	-0.6
Time in novel zone, hab. session 2	0.9	0.9	1.6	-1.0	-1.3	-0.4	-0.9	1.0
Total zone transitions, hab. session 2	0.1	0.2	0.7	0.2	-0.2	0.9	0.3	-0.2
Total locomotion distance, hab. session 2	0.1	0.1	0.2	0.3	0.3	0.5	0.3	-0.3
Locomotion velocity, hab. session 2	0.1	0.1	0.1	0.3	0.2	0.4	0.3	-0.3
Novel to familiar place preference ratio	0.8	0.8	1.3	-0.8	-0.8	-1.1	-0.9	0.9
Novelty place preference	0.4	0.4	1.1	-0.5	-0.4	-1.0	-0.6	0.5
Time in novel zone, NPP test	0.5	0.6	1.3	-0.6	-0.5	-1.2	-0.7	0.7
Total zone transitions, NPP test	0.9	1.3	1.6	-1.1	-1.2	-0.8	-1.2	1.3
Total locomotion distance, NPP test	0.1	0.1	0.2	-0.3	-0.3	-0.2	-0.4	0.4
Locomotion velocity, NPP test	0.1	0.1	0.2	-0.3	-0.1	-0.3	-0.4	0.4
Pavlov. Cond. lever latency	0.9	1.2	1.9	-1.2	-1.4	-0.2	-1.1	1.2
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.2	-0.3	-0.1	-0.1	0.1
Pavlov. Cond. change in total contacts	0.2	0.2	0.3	0.3	0.3	0.6	0.5	-0.5
Pavlov. Cond. index score	0.2	0.3	0.4	0.6	0.5	0.3	0.6	-0.6
Pavlov. Cond. latency score	0.4	0.6	0.7	0.8	0.8	0.4	0.8	-0.8
Pavlov. Cond. lever contacts	1.9	2.2	3.5	1.5	1.9	0.3	1.5	-1.6
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	-0.1	-0.0	-0.2	-0.2	0.2
Pavlov. Cond. intertrial magazine entries	0.6	0.7	0.9	-1.0	-0.9	-0.6	-0.9	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.2	0.4	0.5	0.1	0.5	-0.5
Pavlov. Cond. response bias	0.7	0.9	1.2	0.9	1.1	0.4	1.0	-1.1
Bone: apparent density	0.7	1.1	1.4	-1.0	-1.2	-0.8	-1.1	1.1
Bone surface	0.3	0.5	0.8	-0.7	-0.7	-0.9	-0.7	0.7
Bone volume	0.5	0.8	1.1	-0.9	-0.8	-1.0	-0.9	0.9
Bone: connectivity density	0.4	0.6	1.0	-0.8	-0.6	-1.0	-0.8	0.7
Bone: cortical apparent density	1.4	1.8	2.1	-1.4	-1.5	-0.9	-1.4	1.4
Bone: cortical area	1.4	2.1	2.6	1.5	1.0	1.6	1.5	-1.5
Bone: cortical porosity	1.8	1.9	2.8	1.3	0.8	1.7	1.5	-1.4
Bone: cortical porosity	1.5	1.6	2.5	1.2	0.7	1.6	1.4	-1.3
Bone: cortical thickness	0.1	0.1	0.4	-0.0	-0.6	0.6	0.0	0.1
Bone: cortical thickness	1.5	1.8	3.9	1.2	0.4	2.0	1.4	-1.2
Bone: cortical tissue density	1.1	1.4	1.7	-1.2	-1.3	-0.8	-1.2	1.3
Bone: elastic displacement	0.6	0.7	1.2	0.9	1.1	0.2	0.8	-0.9
Bone: elastic work	3.3	4.3	5.0	2.2	1.7	2.1	2.2	-2.2
Bone: endosteal estimation	2.1	4.6	5.2	2.3	2.1	1.8	2.2	-2.2
Bone: endosteal perimeter	3.4	7.0	8.0	2.8	2.7	2.0	2.8	-2.8
Bone: final force	0.8	1.3	3.8	0.9	0.0	1.9	1.0	-0.8
Bone: final moment	0.9	1.6	4.6	1.1	0.1	2.1	1.1	-0.9
Bone: marrow area	2.1	4.5	5.2	2.3	2.1	1.8	2.2	-2.2
Bone: maximum diameter	6.2	11.3	12.8	3.5	3.0	3.2	3.6	-3.5
Bone: maximum force	0.9	1.6	4.8	1.1	0.0	2.2	1.1	-0.9
Bone: maximum moment	1.1	2.0	5.7	1.2	0.1	2.4	1.3	-1.0
Bone: minimum diameter	2.0	3.7	4.4	2.0	2.0	1.3	2.1	-2.1
Bone: periosteal estimation	2.4	5.0	5.7	2.4	1.9	2.1	2.4	-2.3
Bone: periosteal perimeter	4.7	7.7	8.9	2.9	2.8	2.1	3.0	-3.0
Bone: post-yield work	0.9	1.3	2.1	-1.2	-1.5	-0.2	-1.1	1.3
Bone: stiffness	0.9	1.4	3.6	-0.7	-1.9	1.3	-0.6	0.9
Bone: tissue strength	0.6	0.6	1.4	-0.6	-1.2	0.4	-0.6	0.8
Bone: trabecular number	0.6	0.9	1.9	-0.9	-0.6	-1.4	-0.9	0.8
Bone: trabecular spacing	2.7	3.5	3.8	1.8	1.8	1.9	1.9	-1.9
Bone: trabecular thickness	0.1	0.1	0.3	-0.3	-0.3	-0.5	-0.3	0.3
Bone: trabecular tissue density	1.6	2.3	3.6	-1.6	-1.9	-0.6	-1.5	1.6
Breakpoint value in progressive ratio session	0.3	0.3	0.7	-0.4	-0.8	0.6	-0.3	0.4
Distance traveled before self-admin	0.3	0.3	0.7	0.5	0.9	0.0	0.5	-0.6
Distance traveled after self-admin	0.9	1.0	1.4	1.0	0.8	1.2	1.1	-1.0
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	-0.1	-0.4	0.5	-0.0	0.1
Delta time in open arm before/after self-admin	0.3	0.3	0.9	0.1	0.6	-0.9	-0.1	-0.1
Diff in mean of infusions in LGA sessions	0.4	0.4	1.8	0.3	-0.3	1.3	0.4	-0.3
Extinction: sum of active levers before priming	0.2	0.2	0.6	-0.3	-0.8	0.4	-0.4	0.4
Active lever presses in extinction session 6	1.0	1.0	2.7	0.8	0.4	1.6	0.9	-0.8
Delta distance traveled before/after self-admin	0.3	0.4	0.5	0.6	0.6	0.4	0.7	-0.7
Delta ambulatory time before/after self-admin	0.3	0.3	0.4	0.5	0.4	0.5	0.6	-0.6
Time in closed arm before self-admin	0.3	0.4	1.1	-0.5	-1.1	0.0	-0.5	0.6
Time in closed arm after self-admin	0.0	0.0	0.0	0.2	-0.2	0.2	0.2	-0.1
Time in open arm before self-admin	0.4	0.4	1.2	-0.5	0.3	-1.1	-0.5	0.4
Time in open arm after self-admin	0.3	0.4	0.6	-0.6	0.0	-0.8	-0.7	0.6
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.9	-0.1	-0.6	0.9	-0.0	0.1
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.7	-0.3	0.1	-0.8	-0.4	0.3
Time to tail flick, vehicle, after self-admin	0.4	0.4	0.5	0.7	0.7	0.4	0.7	-0.7
Time to tail flick, test, before self-admin	2.0	1.9	2.9	1.5	1.7	0.3	1.4	-1.5
Time to tail flick, test, after self-admin	0.2	0.2	0.4	0.1	-0.7	0.6	-0.0	0.1
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	1.4	0.5	0.1	1.2	0.7	-0.6
Delta time to tail flick, test, before/after SA	2.3	2.1	4.1	-1.4	-2.0	-0.1	-1.4	1.6
Ambulatory time before self-admin	0.1	0.1	0.4	0.3	0.7	-0.2	0.2	-0.3
Ambulatory time after self-admin	0.1	0.1	0.3	0.3	0.1	0.5	0.4	-0.4
Total heroin consumption	0.4	0.5	2.3	0.3	-0.1	1.5	0.4	-0.3
Area under the delay curve	4.7	5.0	6.0	-2.4	-2.0	-1.9	-2.4	2.4
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	0.0	0.2	-0.1	0.1	-0.1
Delay disc. indifference point, 16s delay	5.5	5.6	6.3	-2.5	-2.3	-2.0	-2.5	2.5
Delay disc. indifference point, 2s delay	0.7	0.8	1.2	-1.1	-0.9	-0.5	-0.9	1.0
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	-0.2	-0.4	0.3	-0.2	0.2
Delay disc. indifference point, 4s delay	6.4	6.8	8.2	-2.9	-2.3	-2.0	-2.9	2.8
Delay disc. indifference point, 8s delay	4.5	4.7	5.5	-2.3	-2.0	-1.7	-2.3	2.3
Delay discount exponential model param	4.8	5.1	6.1	2.5	2.0	1.9	2.4	-2.4
Delay discount hyperbolic model param	4.4	4.7	5.6	2.4	1.9	1.8	2.3	-2.3
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	0.3	0.4	0.0	0.3	-0.3
Change in fecal boli incidents, locomotor task	0.4	0.4	0.9	-0.5	-0.2	-0.9	-0.6	0.6
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	0.2	0.1	0.1	0.1	-0.0
Bouts of movement, locomotor time 1	0.6	0.7	1.1	0.9	0.6	1.0	0.8	-0.8
Total resting periods, locomotor time 1	0.3	0.3	1.1	0.4	-0.0	1.0	0.4	-0.3
Rest time, locomotor task time 1	0.5	0.5	0.7	0.8	0.8	0.6	0.7	-0.7
Distance moved, locomotor task time 1	0.0	0.1	0.1	0.1	0.3	0.2	0.2	-0.2
Vertical activity count, locomotor time 1	0.1	0.1	0.2	-0.4	-0.4	0.1	-0.2	0.3
Time >=10cm from walls, locomotor time 2	0.3	0.3	0.7	0.6	0.1	0.8	0.6	-0.5
Bouts of movement, locomotor time 2	1.1	1.2	2.0	-1.1	-1.4	-0.2	-1.1	1.2
Total resting periods, locomotor time 2	1.2	1.3	2.1	-1.1	-1.5	-0.2	-1.2	1.2
Rest time, locomotor task time 2	2.1	2.5	6.3	-1.4	-0.4	-2.5	-1.5	1.3
Distance moved, locomotor task time 2	3.4	4.0	5.1	2.1	1.5	2.3	2.1	-2.0
Vertical activity count, locomotor time 2	3.4	3.8	5.4	1.9	1.3	2.3	2.1	-1.9
Weight adjusted by age	1.6	1.8	2.0	1.3	1.1	1.4	1.4	-1.4
Seeking ratio, delayed vs. immediate footshock	1.3	1.5	2.1	-1.5	-1.3	-0.7	-1.3	1.3
Locomotion in novel chamber	0.8	1.0	3.8	-0.3	0.7	-1.9	-0.5	0.3
Locomotion in novel chamber post-restriction	0.0	0.0	0.0	-0.1	-0.2	0.1	-0.2	0.2
Progressive ratio	0.4	0.4	0.7	-0.7	-0.4	-0.8	-0.7	0.6
Food seeking constrained by brief footshock	0.7	0.8	1.1	0.8	0.7	1.0	1.0	-0.9
Seeking ratio, punishment vs. effort	0.9	1.1	2.7	0.9	0.2	1.7	1.0	-0.9
Run reversals in cocaine runway, females	0.3	0.3	1.2	-0.3	0.2	-1.1	-0.4	0.3
Run reversals in cocaine runway, males	0.7	0.7	1.8	0.8	1.3	-0.5	0.6	-0.8
Latency to leave start box in cocaine runway	2.2	2.4	2.6	1.6	1.5	1.5	1.6	-1.6
Latency to leave start box in cocaine runway, F	1.0	1.1	1.2	1.1	1.0	0.9	1.1	-1.1
Latency to leave start box in cocaine runway, M	2.2	2.1	2.3	1.5	1.3	1.5	1.5	-1.5
Cd content in liver	0.2	0.2	0.4	-0.4	-0.6	0.1	-0.4	0.5
Co content in liver	0.9	1.0	1.5	1.0	1.2	0.5	1.0	-1.1
Cu content in liver	7.3	8.8	10.4	-3.1	-2.9	-2.3	-3.2	3.2
Fe content in liver	0.3	0.3	0.4	0.6	0.3	0.6	0.6	-0.6
K content in liver	0.2	0.2	0.7	-0.0	-0.5	0.9	0.0	0.1
Mg content in liver	0.2	0.2	0.7	0.0	-0.6	0.8	-0.1	0.2
Mn content in liver	1.6	1.9	2.9	1.5	1.7	0.6	1.4	-1.5
Na content in liver	3.2	3.4	4.2	-2.0	-2.1	-1.2	-1.8	1.9
Rb content in liver	0.7	0.9	1.6	-0.9	-1.3	0.0	-0.9	1.0
Se content in liver	0.1	0.1	0.2	0.4	0.4	-0.2	0.1	-0.2
Sr content in liver	1.2	1.1	2.8	-0.7	-0.1	-1.7	-1.1	1.0
Zn content in liver	0.8	0.9	1.6	-0.9	-0.7	-1.3	-1.0	0.9