Serpinh1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000016831	0.5	0.19	4.1e-09	0.07	0.07	0.09	0.06	2.4e-08	4.1e-08	1.7e-10	4.6e-07
2	Adipose	intron excision ratio	chr1:153647208:153649542	0.04	0.03	8.7e-04	0.03	0.02	0.01	0.02	8.5e-04	4.5e-03	3.5e-02	2.7e-03
3	Adipose	intron excision ratio	chr1:153647208:153650745	0.02	0.02	8.7e-03	0.02	0.02	0.01	0.02	4.0e-03	4.9e-03	1.8e-02	4.6e-03
4	Adipose	mRNA stability	ENSRNOG00000016831	0.11	0.06	4.4e-11	0.09	0.08	0.08	0.08	3.0e-10	7.3e-09	5.1e-09	4.6e-09
5	Brain	mRNA stability	ENSRNOG00000016831	0.05	0.04	1.1e-03	0.02	0.02	0.03	0.02	1.1e-02	3.9e-03	2.0e-03	1.0e-02
6	Liver	gene expression	ENSRNOG00000016831	0.81	0.09	0.0e+00	0.56	0.59	0.59	0.58	2.1e-74	1.3e-80	3.7e-81	5.1e-79

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
BMI with tail	0.0	0.2	0.7	-0.8	-0.1	0.2	0.1	-0.2	-0.3
BMI without tail	0.8	1.6	2.4	1.3	1.2	-1.4	1.5	-0.9	1.3
Body weight	0.2	0.7	1.3	-0.6	1.1	-0.8	1.1	-0.6	0.5
Epididymis fat weight	0.4	0.8	2.7	-1.6	-0.1	0.5	-0.3	-1.2	-0.7
Glucose	0.1	0.1	0.3	-0.6	-0.2	0.3	-0.3	0.0	-0.3
Heart weight	1.1	1.6	3.4	1.8	1.1	-1.1	1.2	0.8	1.3
Left kidney weight	1.0	2.7	4.7	0.7	2.2	-2.0	1.9	0.5	1.8
Right kidney weight	0.6	1.8	2.9	1.2	1.7	-1.4	1.5	0.2	1.4
Tail length	2.2	6.6	9.6	1.9	3.1	-3.1	3.0	-0.2	2.8
Length with tail	0.5	1.8	3.7	0.3	1.9	-1.7	1.6	-0.5	1.3
Length without tail	0.8	1.7	4.9	-2.2	-0.8	1.2	-1.2	0.1	-1.3
Liver weight, left	0.3	0.5	2.2	-0.4	-0.3	0.4	-0.4	-1.5	-0.5
Liver weight, right	1.1	1.8	5.1	-1.2	-0.8	1.2	-1.0	-2.3	-1.2
Parametrial fat weight	0.3	0.6	1.8	-0.8	-0.7	0.5	-0.2	-1.3	-0.8
Retroperitoneal fat weight	1.7	5.5	12.8	-2.6	-1.5	1.8	-1.5	-3.6	-2.4
Intraocular pressure	0.3	0.4	1.3	0.4	0.3	-0.4	0.5	1.2	0.6
Extensor digitorum longus weight	0.1	0.4	1.1	0.6	0.0	-0.5	0.6	-1.1	0.3
Soleus weight	0.2	0.6	1.8	0.6	0.4	-0.6	0.7	-1.3	0.4
Tibialis anterior weight	0.1	0.5	0.9	0.4	0.7	-0.8	0.9	0.0	0.7
Tibia length	1.2	3.3	6.9	1.0	1.8	-1.7	1.7	2.6	1.7
Number of licking bursts	4.9	5.8	7.2	-2.3	-2.5	2.4	-2.3	-2.3	-2.7
Food consumed during 24 hour testing period	3.2	3.8	7.1	2.7	2.0	-1.8	1.5	1.0	2.3
Times rat made contact with spout	0.3	0.3	1.8	0.3	-0.2	-0.0	-0.2	-1.4	0.0
Mean time between licks in bursts	4.7	6.6	11.3	1.5	3.4	-2.9	2.8	1.5	2.8
Mean num. licks in bursts	4.6	5.5	7.4	2.5	2.3	-2.4	2.2	1.8	2.7
Std. dev. time between licks in bursts	1.4	1.6	2.9	0.4	1.7	-1.7	1.4	0.4	1.3
Water consumed over 24 hours	1.0	1.2	3.0	0.6	-1.1	0.9	-1.1	-1.7	-0.7
Indifference point 0 sec	5.9	9.4	11.5	2.3	3.3	-3.3	3.4	2.7	3.3
Indifference point AUC	0.1	0.2	0.5	-0.1	0.5	-0.3	0.7	-0.2	0.3
Indifference point function ln k	0.9	1.3	2.8	0.8	0.9	-1.1	0.8	1.7	1.2
Indifference point function log k	0.9	1.3	2.8	0.8	0.9	-1.1	0.8	1.7	1.2
Delay discounting total patch changes 0 sec	4.6	7.4	9.3	1.9	2.9	-2.9	3.1	2.5	2.9
Delay discounting total patch changes 12 sec	2.3	3.1	5.1	1.6	1.9	-1.8	2.3	0.7	1.8
Delay discounting total patch changes 18 sec	3.0	3.9	5.3	2.0	2.0	-2.1	2.3	0.9	2.2
Delay discounting total patch changes 24 sec	0.6	0.7	1.6	-0.5	1.3	-0.6	0.9	0.9	0.6
Delay discounting total patch changes 6 sec	1.2	1.8	2.9	1.3	1.2	-1.3	1.7	1.1	1.4
Delay discounting time to switch 0 sec	4.3	6.5	8.3	-1.9	-2.8	2.8	-2.8	-1.9	-2.9
Delay discounting water rate 0 sec	3.3	5.2	6.2	1.8	2.5	-2.3	2.5	2.1	2.5
Delay discounting water rate 12 sec	2.0	3.0	3.9	2.0	1.6	-1.7	1.6	1.5	1.9
Delay discounting water rate 18 sec	0.9	1.2	1.5	1.2	1.1	-1.1	1.0	0.7	1.2
Delay discounting water rate 24 sec	0.7	1.0	1.9	1.2	0.8	-0.7	0.7	1.4	1.0
Delay discounting water rate 6 sec	0.6	0.9	1.2	1.1	0.8	-1.0	0.7	1.1	1.1
Locomotor activity	1.5	2.3	6.0	2.4	1.3	-1.4	1.1	0.4	1.7
Locomotor testing distance	2.7	4.5	5.9	2.3	2.4	-2.3	1.9	1.2	2.4
Locomotor testing rearing	1.2	1.9	3.0	1.1	1.7	-1.6	1.4	0.4	1.5
Light reinforcement 1	1.5	2.8	4.0	-1.1	-1.6	1.7	-1.7	-2.0	-1.7
Light reinforcement 2	0.1	0.1	0.3	0.2	-0.3	0.5	-0.5	-0.2	-0.3
Reaction time number correct	0.1	0.1	0.2	0.5	0.0	0.2	-0.4	0.5	0.1
Reaction time mean minus median	0.9	1.2	1.8	0.8	1.1	-1.3	1.2	0.5	1.2
Reaction time mean minus median AUC	1.1	1.4	1.8	1.3	1.2	-1.3	1.2	0.7	1.3
Reaction time num false alarms	1.4	1.9	2.5	-1.2	-1.3	1.5	-1.3	-1.6	-1.5
Reaction time num false alarms AUC	1.0	1.3	1.6	-1.1	-1.0	1.3	-1.2	-1.1	-1.2
Reaction time trials correct on left	0.1	0.1	0.2	0.5	0.0	0.2	-0.4	0.5	0.1
Reaction time trials on left	0.1	0.1	0.2	0.4	0.0	0.2	-0.5	0.5	0.1
Reaction time mean	0.5	0.6	0.9	-0.8	-0.9	0.8	-0.5	-0.8	-0.9
Reaction time mean AUC	1.0	1.3	1.6	-1.0	-1.3	1.2	-0.9	-1.1	-1.3
Median of all reaction times	1.2	1.6	2.2	-1.2	-1.5	1.4	-1.0	-1.1	-1.5
Reaction time omissions	0.3	0.4	1.6	-1.3	-0.4	0.5	-0.4	-0.1	-0.7
Reaction time false alarm rate	1.1	1.5	1.9	-1.3	-1.1	1.3	-1.0	-1.3	-1.4
Reaction time premature initiation rate	2.4	3.2	5.4	1.4	1.8	-2.2	2.3	0.5	1.9
Reaction time premature initiations	2.0	2.9	3.9	1.6	1.7	-2.0	1.9	0.8	1.8
Std. dev. reaction times	0.3	0.4	0.7	0.1	0.6	-0.8	0.8	0.1	0.6
Reaction time trials completed	0.1	0.1	0.2	0.4	0.0	0.2	-0.5	0.5	0.1
Reaction time trials AUC	0.1	0.1	0.2	0.4	0.1	0.2	-0.4	0.5	0.1
Social response proportion	0.5	0.5	1.3	-0.2	-0.4	0.8	-0.7	-1.1	-0.7
Social responses	0.4	0.5	1.9	-0.6	-0.1	0.4	-0.5	-1.4	-0.5
Social time	4.1	5.3	7.2	-2.3	-2.0	2.7	-2.7	-1.4	-2.5
Conditioned locomotion	0.0	0.0	0.1	0.1	-0.3	0.2	-0.2	0.1	-0.1
Cocaine response after cond. corrected	2.5	2.8	5.5	-2.3	-1.3	1.8	-1.3	-0.8	-2.0
Cocaine response after cond. not corrected	1.4	1.5	3.9	-2.0	-0.7	1.3	-1.0	-0.2	-1.5
Cocaine response before conditioning	1.0	1.2	2.1	1.4	1.1	-1.0	0.7	0.9	1.3
Saline control response	1.5	2.0	3.4	0.9	1.8	-1.5	1.5	1.0	1.6
Condit. Reinf. active minus inactive responses	6.0	7.4	12.1	1.0	3.5	-2.9	2.9	2.6	2.8
Condit. Reinf. active-inactive response ratio	1.1	1.1	2.2	-0.4	1.5	-0.9	0.9	1.5	0.9
Condit. Reinf. active responses	8.3	11.6	18.1	1.9	4.3	-3.7	3.7	2.7	3.7
Condit. Reinf. inactive responses	5.7	7.1	9.6	2.3	3.1	-3.0	2.9	1.3	3.0
Condit. Reinf. lever presses	17.3	23.9	29.6	3.2	5.4	-5.2	5.4	4.4	5.2
Condit. Reinf. lever reinforcers received	9.3	13.1	20.2	1.9	4.5	-3.9	3.9	3.1	3.9
Pavlov. Cond. lever latency	17.9	24.5	31.0	-3.1	-5.6	5.1	-5.4	-4.8	-5.2
Pavlov. Cond. magazine entry latency	4.9	5.6	7.7	1.6	2.3	-2.3	2.7	2.8	2.4
Pavlov. Cond. change in total contacts	12.2	17.0	22.6	2.1	4.8	-4.1	4.4	4.7	4.2
Pavlov. Cond. index score	14.3	18.6	23.0	2.4	4.7	-4.4	4.8	4.6	4.4
Pavlov. Cond. latency score	12.9	16.3	20.2	2.2	4.4	-4.1	4.5	4.4	4.1
Pavlov. Cond. lever contacts	18.8	26.2	32.3	3.2	5.7	-5.4	5.7	5.0	5.4
Pavlov. Cond. magazine entry number	7.0	8.6	13.4	-1.5	-3.2	2.8	-3.2	-3.7	-2.9
Pavlov. Cond. intertrial magazine entries	0.2	0.3	1.1	0.1	0.4	-0.4	0.0	-1.1	0.3
Pavlov. Cond. lever-magazine prob. diff.	13.2	17.1	21.3	2.1	4.6	-4.2	4.6	4.5	4.2
Pavlov. Cond. response bias	19.4	26.8	32.7	3.4	5.7	-5.4	5.7	5.1	5.5
Conditioned reinforcement - actives	1.4	1.3	2.7	0.5	1.1	-1.0	1.1	1.7	1.2
Conditioned reinforcement - inactives	0.8	0.9	1.5	-1.2	-0.8	0.9	-1.0	-0.7	-1.0
Conditioned locomotion	0.7	0.9	2.4	1.0	0.6	-0.6	0.6	1.5	0.9
Intermittent access intake day 1-15 change	1.0	1.0	2.3	0.3	0.8	-0.9	1.0	1.5	0.9
Intermittent access intake escalation	1.3	1.3	2.8	0.5	1.0	-1.1	1.2	1.7	1.1
Intermittent access intake escalation 2	0.5	0.5	0.8	0.1	0.7	-0.8	0.9	0.8	0.7
Intermitt. access day 1 inactive lever presses	0.8	0.8	1.2	-1.1	-0.8	0.9	-1.0	-0.6	-1.0
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.3	0.2	-0.3	0.5	-0.5	-0.0	-0.2
Intermitt. access escalation Index	0.3	0.3	1.2	1.1	0.3	-0.2	0.4	0.1	0.5
Intermittent access day 1 total infusions	0.7	0.8	1.4	1.2	0.8	-0.9	0.9	0.0	1.0
Intermittent access day 15 total infusions	1.2	1.3	1.7	1.0	1.0	-1.1	1.2	1.3	1.2
Intermittent access terminal intake (last 3 days)	1.0	1.1	1.4	1.0	1.0	-1.1	1.2	0.9	1.2
Intermittent access total infusions	0.5	0.5	0.7	0.8	0.7	-0.8	0.8	0.4	0.8
Intermittent access day 1 locomotion	0.1	0.1	0.3	0.5	-0.2	0.1	-0.2	-0.1	0.0
Intermittent access day 15 total locomotion	0.9	1.0	1.4	1.2	0.8	-0.9	0.9	1.0	1.1
Intermittent access total locomotion	0.3	0.4	0.5	0.7	0.6	-0.6	0.6	0.4	0.7
Intermittent access standard deviation	0.1	0.1	0.2	-0.1	0.4	-0.2	0.3	0.1	0.2
Cocaine induced anxiety	1.8	2.0	2.4	-1.1	-1.5	1.5	-1.5	-1.3	-1.5
Post-drug Anxiety	0.6	0.6	0.9	-1.0	-0.7	0.7	-0.7	-0.8	-0.8
Baseline Anxiety	1.7	1.8	2.4	0.7	1.5	-1.5	1.5	1.3	1.4
Lifetime Intake	0.6	0.7	0.9	0.7	0.8	-0.9	1.0	0.6	1.0
Incentive Sensitization - Responses	2.8	2.8	3.9	1.0	1.8	-1.8	2.0	1.4	1.8
Incentive Sensitization - Breakpoint	2.7	2.7	3.7	1.1	1.8	-1.8	1.9	1.4	1.8
Progressive ratio test 1 active lever presses	0.6	0.6	0.9	-1.0	-0.8	0.7	-0.7	-0.5	-0.8
Progressive ratio test 1 breakpoint	0.5	0.5	0.8	-0.9	-0.7	0.6	-0.6	-0.5	-0.7
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	-0.1	0.1	-0.2	0.3	0.0	0.2
Progressive ratio test 2 active lever presses	1.0	1.0	1.6	0.4	1.0	-1.2	1.3	0.9	1.1
Progressive ratio test 2 breakpoint	1.0	1.1	1.7	0.5	1.1	-1.3	1.3	0.8	1.1
Progressive ratio test 2 inactive lever presses	0.5	0.6	1.4	1.2	0.6	-0.6	0.8	0.4	0.9
Total sessions with >9 infusions	2.2	2.4	2.9	1.3	1.3	-1.6	1.7	1.6	1.7
Short access day 1 total inactive lever presses	0.3	0.4	0.6	-0.2	-0.6	0.8	-0.7	-0.6	-0.6
Short access day 10 total inactive lever presses	0.2	0.2	0.3	-0.2	-0.5	0.5	-0.6	-0.1	-0.4
Short access day 1 total infusions	1.8	1.9	2.6	1.0	1.5	-1.5	1.6	0.9	1.6
Short access day 10 total infusions	0.6	0.6	1.0	0.2	1.0	-0.9	0.9	0.6	0.8
Short access total infusions	0.6	0.6	1.0	0.4	0.8	-0.9	1.0	0.4	0.9
Short access day 1 locomotion	1.2	1.2	4.2	0.1	0.8	-1.0	0.9	2.1	0.9
Short access day 10 total locomotion	0.3	0.3	0.4	0.4	0.6	-0.6	0.4	0.5	0.5
Short access total locomotion	0.1	0.1	0.2	-0.1	0.2	-0.4	0.2	0.4	0.2
Compulsive drug intake	0.1	0.1	0.7	-0.3	0.1	0.1	-0.1	0.8	-0.1
One hour access (0.3 mA shock)	1.8	2.1	2.7	1.3	1.5	-1.6	1.5	1.1	1.6
One hour access (shock baseline)	1.1	1.2	1.6	1.0	1.1	-1.2	1.2	0.6	1.3
Number of responses in last shaping day	0.6	0.6	1.1	1.1	0.8	-0.8	0.7	-0.3	0.8
Context. condit. distance diff. score	2.4	3.0	4.7	1.3	1.4	-1.7	1.9	2.2	1.7
Locomotion velocity, session 1	0.5	0.6	1.3	-0.6	-0.5	0.8	-1.1	0.3	-0.8
Locomotion distance, session 1	0.5	0.7	3.0	-0.4	0.9	-0.2	0.1	1.7	0.3
Locomotion velocity, session 2	0.0	0.0	0.1	0.1	0.4	-0.1	-0.0	0.3	0.0
Locomotion distance, session 2	0.2	0.4	0.6	0.6	0.8	-0.4	0.2	0.8	0.6
Locomotion velocity, session 3	0.3	0.3	1.2	0.3	0.6	-0.3	0.4	1.1	0.4
Locomotion distance, session 3	0.5	0.6	1.5	0.4	0.8	-0.6	0.5	1.2	0.7
Stereotopy head waving bouts, day 3	0.2	0.3	0.8	-0.4	-0.3	0.4	-0.5	-0.9	-0.4
Stereotopy head waving duration, day 3	0.2	0.2	0.5	0.7	0.3	-0.5	0.4	0.3	0.5
Locomotion velocity, session 7	0.4	0.4	0.9	-1.0	-0.6	0.7	-0.6	-0.0	-0.7
Locomotion distance, session 7	0.1	0.1	0.3	-0.6	-0.3	0.3	-0.2	0.0	-0.4
Stereotopy head waving bouts, day 7	1.4	1.5	2.1	1.0	1.4	-1.1	1.1	1.3	1.4
Stereotopy head waving duration, day 7	2.3	2.9	3.6	1.7	1.8	-1.6	1.7	1.3	1.9
Locomotion velocity, session 8	1.5	1.8	2.8	1.7	1.0	-1.3	1.3	1.1	1.4
Locomotion distance, session 8	1.8	2.6	5.2	0.8	1.8	-1.5	1.5	2.3	1.5
Degree of sensitization distance	0.2	0.2	0.9	-0.4	-0.2	0.0	0.1	-1.0	-0.3
Degree of sensitization stereotypy	3.5	3.8	5.1	1.4	2.2	-1.8	1.8	2.2	2.1
Condit. Reinf. active minus inactive responses	0.5	0.5	1.1	1.0	0.7	-0.7	0.7	-0.3	0.8
Condit. Reinf. active-inactive response ratio	1.5	1.7	3.5	1.9	1.0	-1.4	1.4	-0.0	1.3
Condit. Reinf. active responses	0.1	0.1	0.3	0.4	0.3	-0.2	0.1	-0.5	0.3
Condit. Reinf. inactive responses	0.3	0.3	0.8	-0.9	-0.2	0.6	-0.7	-0.4	-0.4
Incentive salience index mean	0.4	0.5	0.7	0.8	0.8	-0.7	0.6	-0.1	0.8
Condit. Reinf. lever presses	0.2	0.2	0.4	0.4	0.6	-0.5	0.3	-0.1	0.7
Time in familiar zone, hab. session 1	0.0	0.0	0.2	0.2	-0.1	-0.1	-0.1	-0.5	-0.0
Time in novel zone, hab. session 1	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.2	-0.3	-0.3
Total zone transitions, hab. session 1	0.1	0.1	0.4	0.6	-0.1	-0.1	0.1	0.5	0.2
Total locomotion distance, hab. session 1	0.3	0.5	1.0	-0.9	-0.3	0.5	-0.6	-1.0	-0.7
Locomotion velocity, hab. session 1	0.2	0.2	0.5	-0.6	-0.2	0.3	-0.3	-0.7	-0.5
Time in familiar zone, hab. session 2	2.7	2.8	5.7	2.4	1.2	-1.8	1.7	0.3	1.8
Time in novel zone, hab. session 2	1.5	1.5	3.6	-1.9	-0.6	1.4	-1.2	0.2	-1.3
Total zone transitions, hab. session 2	1.0	1.3	3.8	0.5	1.2	-0.8	1.0	2.0	0.9
Total locomotion distance, hab. session 2	0.1	0.1	0.4	-0.4	0.6	-0.0	0.2	-0.3	0.1
Locomotion velocity, hab. session 2	0.1	0.2	0.6	-0.8	0.5	0.1	0.0	-0.4	-0.1
Novel to familiar place preference ratio	0.3	0.3	1.0	-1.0	0.2	0.2	-0.1	0.6	-0.3
Novelty place preference	0.3	0.3	1.1	-1.0	0.2	0.3	-0.3	0.6	-0.4
Time in novel zone, NPP test	0.2	0.2	0.6	-0.8	0.3	0.1	-0.0	0.7	-0.1
Total zone transitions, NPP test	0.1	0.1	0.5	0.1	0.3	0.1	-0.1	0.7	0.1
Total locomotion distance, NPP test	0.9	1.2	3.0	-1.7	-0.2	1.1	-1.0	-0.7	-1.1
Locomotion velocity, NPP test	1.4	2.0	4.6	-2.1	-0.5	1.5	-1.4	-0.9	-1.5
Pavlov. Cond. lever latency	1.7	2.1	3.2	-1.8	-1.5	1.6	-1.3	-0.2	-1.8
Pavlov. Cond. magazine entry latency	3.1	4.1	5.5	1.6	2.3	-2.2	2.1	1.3	2.3
Pavlov. Cond. change in total contacts	0.9	1.0	2.1	0.3	1.4	-1.0	0.9	0.8	1.1
Pavlov. Cond. index score	3.5	4.5	6.5	2.1	2.3	-2.3	2.1	0.8	2.6
Pavlov. Cond. latency score	3.4	4.3	6.4	2.0	2.3	-2.3	2.0	0.9	2.5
Pavlov. Cond. lever contacts	1.7	2.0	3.2	1.6	1.6	-1.6	1.2	0.1	1.8
Pavlov. Cond. magazine entry number	3.7	4.6	6.3	-1.7	-2.4	2.4	-2.2	-1.5	-2.5
Pavlov. Cond. intertrial magazine entries	2.0	2.4	3.2	-1.1	-1.4	1.8	-1.8	-1.3	-1.7
Pavlov. Cond. lever-magazine prob. diff.	2.9	3.6	5.3	1.9	2.1	-2.1	1.8	0.6	2.3
Pavlov. Cond. response bias	1.6	2.0	2.9	1.6	1.6	-1.5	1.3	0.2	1.7
Bone: apparent density	0.9	1.5	6.3	2.5	-0.6	-0.1	0.2	-1.5	0.5
Bone surface	2.4	4.2	12.2	3.5	1.2	-1.8	2.0	-0.2	2.1
Bone volume	1.9	3.2	11.0	3.3	0.8	-1.4	1.5	-0.7	1.7
Bone: connectivity density	1.3	2.0	9.1	3.0	-0.2	-0.6	0.8	-0.9	1.0
Bone: cortical apparent density	0.9	1.2	2.4	-0.6	-1.2	0.9	-1.2	-1.5	-1.0
Bone: cortical area	0.9	1.3	2.6	1.6	0.9	-1.1	1.5	0.2	1.1
Bone: cortical porosity	0.7	0.7	2.4	-0.2	0.8	-0.6	0.6	1.6	0.7
Bone: cortical porosity	0.4	0.4	1.7	-0.3	0.6	-0.5	0.3	1.3	0.5
Bone: cortical thickness	0.1	0.2	0.3	0.3	-0.6	0.5	-0.3	-0.6	-0.3
Bone: cortical thickness	0.1	0.1	0.4	-0.6	0.3	0.1	-0.1	0.7	0.0
Bone: cortical tissue density	1.0	1.3	2.4	-0.6	-1.2	0.9	-1.2	-1.5	-1.1
Bone: elastic displacement	1.9	2.1	3.7	-0.6	-1.9	1.7	-1.5	-0.8	-1.7
Bone: elastic work	1.8	2.3	4.1	-0.5	-2.0	1.8	-1.6	-1.0	-1.7
Bone: endosteal estimation	1.6	3.6	5.3	1.9	2.0	-2.1	2.3	0.7	2.0
Bone: endosteal perimeter	2.5	5.1	7.0	2.1	2.4	-2.5	2.6	1.1	2.4
Bone: final force	0.2	0.3	1.1	1.0	-0.1	-0.3	0.6	-0.3	0.3
Bone: final moment	0.3	0.6	2.0	1.4	0.2	-0.5	0.8	-0.2	0.6
Bone: marrow area	1.4	3.0	4.8	1.8	1.8	-1.9	2.2	0.5	1.8
Bone: maximum diameter	2.7	5.0	7.8	2.2	2.2	-2.4	2.8	1.3	2.3
Bone: maximum force	0.4	0.7	2.2	1.5	0.3	-0.7	1.0	0.0	0.7
Bone: maximum moment	0.7	1.2	3.3	1.8	0.5	-0.9	1.2	0.1	1.0
Bone: minimum diameter	0.7	1.3	2.0	1.3	1.0	-1.3	1.4	-0.4	1.1
Bone: periosteal estimation	1.7	3.4	5.4	2.0	1.8	-1.9	2.3	0.6	1.9
Bone: periosteal perimeter	2.5	4.1	5.6	2.4	1.9	-2.2	2.2	0.6	2.2
Bone: post-yield work	1.0	1.4	3.8	1.9	0.5	-1.1	1.3	-0.0	1.2
Bone: stiffness	0.1	0.1	0.4	0.2	-0.3	0.0	0.3	-0.6	-0.2
Bone: tissue strength	0.4	0.4	0.6	-0.5	-0.7	0.7	-0.6	0.4	-0.6
Bone: trabecular number	1.2	1.9	3.8	1.9	-1.6	0.8	-0.6	-2.0	-0.5
Bone: trabecular spacing	0.9	1.1	3.1	-1.1	1.1	-0.8	0.6	1.8	0.5
Bone: trabecular thickness	0.5	0.6	1.8	1.3	-0.4	0.1	-0.1	-1.3	0.2
Bone: trabecular tissue density	1.0	1.3	3.6	-1.9	-0.7	0.8	-1.0	-0.9	-1.2
Breakpoint value in progressive ratio session	0.3	0.3	0.4	-0.7	-0.6	0.7	-0.6	0.1	-0.7
Distance traveled before self-admin	0.5	0.5	1.1	-0.5	-0.8	0.5	-0.7	-1.1	-0.7
Distance traveled after self-admin	1.6	1.8	2.8	-0.6	-1.5	1.7	-1.7	-0.9	-1.3
Delta time in closed arm before/after self-admin	0.4	0.4	2.0	-0.6	-0.1	-0.2	0.1	-1.4	-0.2
Delta time in open arm before/after self-admin	2.7	2.6	3.5	1.9	1.7	-1.5	1.7	0.8	1.9
Diff in mean of infusions in LGA sessions	3.2	3.5	4.3	-2.1	-1.7	1.9	-1.7	-1.7	-2.1
Extinction: sum of active levers before priming	0.3	0.3	0.6	-0.8	-0.3	0.6	-0.4	-0.5	-0.5
Active lever presses in extinction session 6	2.1	2.0	7.2	0.4	1.1	-1.1	1.0	2.7	1.2
Delta distance traveled before/after self-admin	0.1	0.1	0.1	0.2	-0.1	0.3	-0.2	0.4	0.1
Delta ambulatory time before/after self-admin	0.2	0.2	0.6	-0.4	-0.1	0.4	-0.4	0.8	-0.0
Time in closed arm before self-admin	1.1	1.3	4.4	2.1	0.6	-0.5	0.4	1.4	0.9
Time in closed arm after self-admin	0.7	0.7	1.0	0.5	-1.0	0.9	-1.0	-0.9	-0.7
Time in open arm before self-admin	3.9	4.1	9.1	-3.0	-1.8	1.6	-1.8	-1.4	-2.2
Time in open arm after self-admin	0.5	0.5	1.1	0.1	0.8	-0.9	1.1	0.2	0.7
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	-0.1	0.1	0.3	-0.2	-0.2	-0.1
Time to tail flick, vehicle, before self-admin	1.5	1.5	5.8	2.4	-0.4	0.0	0.2	-1.7	0.5
Time to tail flick, vehicle, after self-admin	1.7	1.9	2.1	1.4	1.3	-1.3	1.3	1.4	1.5
Time to tail flick, test, before self-admin	0.2	0.2	0.6	0.0	0.4	-0.8	0.5	0.2	0.5
Time to tail flick, test, after self-admin	0.3	0.3	0.6	-0.6	0.8	-0.7	0.3	0.5	0.3
Delta time to tail flick, vehicle, before/after SA	2.5	2.4	8.3	-1.4	1.2	-1.1	1.0	2.9	0.6
Delta time to tail flick, test, before/after SA	0.7	0.6	1.9	-1.4	-0.3	0.6	-0.7	0.3	-0.8
Ambulatory time before self-admin	0.8	0.9	1.2	-0.7	-1.1	0.9	-1.0	-0.7	-1.1
Ambulatory time after self-admin	1.9	2.1	3.5	-0.8	-1.6	1.9	-1.9	-0.6	-1.4
Total heroin consumption	0.1	0.1	0.3	0.3	0.4	-0.2	0.2	0.5	0.3
Area under the delay curve	0.3	0.3	1.4	-1.2	0.2	-0.2	0.0	0.5	-0.3
Delay disc. indifference point, 0s delay	0.7	0.8	1.3	-0.0	1.2	-1.0	0.7	1.1	0.7
Delay disc. indifference point, 16s delay	0.3	0.3	1.0	-1.0	-0.4	0.4	-0.4	0.2	-0.6
Delay disc. indifference point, 2s delay	1.8	2.0	4.0	-1.8	1.3	-1.3	1.0	2.0	0.5
Delay disc. indifference point, 24s delay	1.2	1.1	2.7	0.2	-1.1	1.2	-0.9	-1.6	-0.8
Delay disc. indifference point, 4s delay	1.1	1.2	2.4	-1.5	1.3	-1.2	0.3	1.2	0.2
Delay disc. indifference point, 8s delay	0.3	0.3	0.5	-0.3	0.5	-0.6	0.6	0.7	0.4
Delay discount exponential model param	0.3	0.3	1.5	1.2	-0.1	0.2	0.1	-0.4	0.3
Delay discount hyperbolic model param	0.4	0.4	1.8	1.3	-0.4	0.5	-0.1	-0.7	0.2
Fecal boli incidents, locomotor time 1	0.7	0.7	2.1	1.5	0.8	-0.4	0.4	0.8	0.9
Change in fecal boli incidents, locomotor task	1.9	1.8	3.5	-1.9	-1.3	1.2	-1.1	-0.8	-1.5
Time >=10cm from walls, locomotor time 1	1.1	1.1	3.2	-0.1	0.9	-0.8	0.9	1.8	1.0
Bouts of movement, locomotor time 1	0.1	0.1	0.4	-0.3	0.2	0.1	-0.0	0.6	-0.0
Total resting periods, locomotor time 1	0.1	0.1	0.3	-0.1	-0.2	0.5	-0.4	0.4	-0.3
Rest time, locomotor task time 1	0.9	1.0	2.2	-1.5	-0.5	0.9	-1.2	-0.0	-1.1
Distance moved, locomotor task time 1	1.1	1.2	2.1	1.2	0.6	-1.5	1.4	-0.1	1.1
Vertical activity count, locomotor time 1	1.6	1.6	3.0	1.1	0.9	-1.6	1.7	0.6	1.4
Time >=10cm from walls, locomotor time 2	0.8	0.9	1.9	-0.3	1.2	-0.9	0.8	1.4	0.8
Bouts of movement, locomotor time 2	0.6	0.7	1.0	-0.9	0.8	-1.0	0.7	1.0	0.4
Total resting periods, locomotor time 2	0.6	0.6	2.0	-1.4	0.5	-0.8	0.4	1.0	0.0
Rest time, locomotor task time 2	2.6	3.0	3.8	-1.4	-2.0	1.6	-1.8	-1.8	-1.9
Distance moved, locomotor task time 2	3.1	3.6	4.9	1.1	2.2	-2.0	2.1	1.9	2.0
Vertical activity count, locomotor time 2	2.4	2.6	4.3	1.4	1.7	-1.7	2.1	1.0	1.8
Weight adjusted by age	0.8	0.9	1.3	0.6	1.2	-1.2	1.0	-0.1	1.1
Seeking ratio, delayed vs. immediate footshock	2.0	2.3	3.3	0.5	-1.6	1.8	-1.7	-1.8	-1.3
Locomotion in novel chamber	0.7	0.9	1.6	1.3	0.6	-0.7	0.5	1.1	1.0
Locomotion in novel chamber post-restriction	2.1	2.5	8.3	-0.1	1.3	-1.1	1.4	2.9	1.3
Progressive ratio	0.0	0.0	0.1	0.0	0.0	0.0	-0.0	0.2	0.1
Food seeking constrained by brief footshock	1.2	1.5	2.4	0.4	1.5	-1.3	1.4	1.1	1.3
Seeking ratio, punishment vs. effort	0.7	0.9	1.5	0.2	1.2	-1.1	1.2	0.6	0.9
Run reversals in cocaine runway, females	0.5	0.5	2.4	-0.1	0.3	-0.6	0.6	-1.5	0.2
Run reversals in cocaine runway, males	0.1	0.1	0.1	0.2	-0.3	-0.1	-0.1	-0.3	-0.1
Latency to leave start box in cocaine runway	3.4	3.7	11.4	-3.4	-1.3	1.4	-1.6	-0.5	-2.1
Latency to leave start box in cocaine runway, F	2.5	2.8	10.9	-3.3	-0.8	1.0	-1.1	-0.3	-1.7
Latency to leave start box in cocaine runway, M	0.5	0.4	0.7	-0.8	-0.8	0.6	-0.7	-0.1	-0.7
Cd content in liver	0.3	0.3	1.1	0.1	-0.5	0.5	-0.3	-1.0	-0.5
Co content in liver	1.7	2.0	2.8	1.5	1.7	-1.6	1.2	0.7	1.5
Cu content in liver	0.6	0.7	1.6	-0.2	1.3	-1.0	0.6	0.4	0.8
Fe content in liver	0.1	0.2	0.8	-0.9	-0.1	0.2	-0.3	0.0	-0.3
K content in liver	0.1	0.1	0.4	-0.1	-0.0	0.1	-0.1	-0.6	-0.1
Mg content in liver	0.2	0.2	0.3	-0.1	0.5	-0.4	0.6	0.5	0.4
Mn content in liver	1.6	1.8	3.0	-0.7	-1.5	1.7	-1.5	-0.6	-1.6
Na content in liver	0.4	0.4	1.5	-0.5	0.7	-0.4	0.3	1.2	0.3
Rb content in liver	1.4	1.7	2.5	1.5	1.2	-1.5	1.3	0.4	1.6
Se content in liver	4.6	5.6	7.6	-1.8	-2.3	2.8	-2.6	-1.8	-2.7
Sr content in liver	0.1	0.1	0.2	-0.0	-0.1	0.4	-0.2	0.3	-0.2
Zn content in liver	5.1	5.6	7.3	1.6	2.7	-2.5	2.5	2.1	2.6