| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Brain | intron excision ratio | chr1:201091617:201104058 | 0.0250 | 0.0210 | 7.9e-03 | 0.013 | 0.027 | 0.027 | 0.022 | 0.01800 | 0.00150 | 0.00140 | 0.00360 |
| 2 | IL | isoform ratio | ENSRNOT00000023020 | 0.1660 | 0.1200 | 7.8e-03 | 0.098 | 0.003 | 0.050 | 0.052 | 0.00240 | 0.27000 | 0.02500 | 0.02200 |
| 3 | Liver | isoform ratio | ENSRNOT00000022824 | 0.0459 | 0.0296 | 8.8e-06 | 0.029 | 0.036 | 0.027 | 0.028 | 0.00035 | 0.00007 | 0.00047 | 0.00039 |
| 4 | Liver | isoform ratio | ENSRNOT00000096831 | 0.0316 | 0.0280 | 5.7e-03 | 0.002 | 0.005 | 0.010 | 0.004 | 0.19000 | 0.07300 | 0.02600 | 0.09400 |
| 5 | PL | mRNA stability | ENSRNOG00000016791 | 0.0541 | 0.0407 | 1.3e-03 | 0.008 | 0.026 | 0.018 | 0.016 | 0.08000 | 0.00440 | 0.01500 | 0.01900 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 |
|---|---|---|---|---|---|---|---|---|
| Bone: post-yield work | 8.5 | 11.6 | 16.3 | -4.0 | -3.2 | 3.7 | -3.8 | -1.6 |
| Intermittent access day 1 total infusions | 5.0 | 5.7 | 9.2 | -3.0 | -3.0 | 2.0 | -2.5 | 0.4 |
| Tibialis anterior weight | 4.6 | 15.9 | 34.5 | 4.4 | 5.9 | -2.1 | 3.3 | -3.1 |
| Delay discounting water rate 12 sec | 4.3 | 6.4 | 16.5 | 1.6 | -0.2 | -2.9 | 2.1 | 4.1 |
| Intermittent access total locomotion | 4.3 | 4.9 | 9.9 | -2.6 | -3.1 | 1.3 | -2.1 | 1.3 |
| Short access day 10 total infusions | 3.9 | 4.3 | 6.6 | -2.6 | -2.2 | 2.1 | -2.4 | -0.6 |
| Delta time to tail flick, test, before/after SA | 3.9 | 3.5 | 5.4 | 2.2 | 2.0 | -1.8 | 2.3 | 0.4 |
| Delay discounting water rate 0 sec | 3.6 | 5.7 | 12.7 | 1.8 | 0.2 | -2.8 | 2.2 | 3.6 |
| Total zone transitions, hab. session 2 | 3.6 | 4.7 | 6.8 | -2.1 | -1.0 | 2.6 | -2.3 | -2.4 |
| Bone: cortical thickness | 3.5 | 5.7 | 10.9 | 2.9 | 3.3 | -1.7 | 2.3 | -1.1 |
| Progressive ratio | 3.5 | 4.0 | 6.5 | -1.7 | -0.6 | 2.5 | -2.0 | -2.6 |
| Conditioned locomotion | 3.4 | 4.1 | 14.3 | 0.3 | -1.4 | -1.8 | 0.8 | 3.8 |
| Intermittent access day 15 total infusions | 3.4 | 3.8 | 8.4 | -2.0 | -2.9 | 0.5 | -1.3 | 2.2 |
| Mg content in liver | 3.4 | 3.6 | 4.7 | -2.2 | -1.6 | 2.1 | -2.2 | -1.2 |
| Intermittent access day 1 locomotion | 3.3 | 3.4 | 5.4 | -2.3 | -2.1 | 1.7 | -2.1 | -0.1 |
| Time >=10cm from walls, locomotor time 1 | 3.3 | 3.4 | 5.2 | -2.2 | -2.3 | 1.6 | -2.0 | 0.0 |
| Intermittent access terminal intake (last 3 days) | 3.2 | 3.5 | 7.4 | -2.2 | -2.7 | 0.9 | -1.5 | 1.5 |
| Progressive ratio test 2 inactive lever presses | 3.2 | 3.7 | 7.8 | -1.8 | -2.8 | 0.3 | -1.3 | 2.3 |
| One hour access (shock baseline) | 3.2 | 3.7 | 8.5 | -1.5 | -2.7 | -0.2 | -0.7 | 2.9 |
| Bone: connectivity density | 3.2 | 5.0 | 8.4 | -1.9 | -0.6 | 2.7 | -2.3 | -2.9 |
| Sum of active levers in priming session hrs 5-6 | 3.2 | 3.1 | 4.1 | 2.0 | 1.7 | -1.9 | 2.0 | 0.8 |
| Bone: elastic displacement | 3.1 | 3.5 | 4.5 | 2.1 | 1.4 | -2.1 | 2.1 | 1.4 |
| Bone: endosteal perimeter | 2.9 | 6.0 | 11.4 | -2.9 | -3.4 | 1.8 | -2.4 | 1.0 |
| Conditioned locomotion | 2.8 | 3.3 | 5.7 | 2.2 | 2.4 | -1.5 | 1.8 | -0.4 |
| Intermittent access total infusions | 2.8 | 3.1 | 6.0 | -2.2 | -2.5 | 1.1 | -1.7 | 0.9 |
| Bone: apparent density | 2.8 | 4.6 | 6.6 | -2.3 | -1.4 | 2.6 | -2.4 | -1.9 |
| Bone surface | 2.7 | 4.7 | 8.5 | -1.8 | -0.5 | 2.6 | -2.2 | -2.9 |
| Delay discounting water rate 24 sec | 2.6 | 3.6 | 6.7 | 1.6 | 0.5 | -2.2 | 1.8 | 2.6 |
| One hour access (0.3 mA shock) | 2.6 | 3.0 | 6.6 | -1.4 | -2.5 | -0.1 | -0.8 | 2.6 |
| Rb content in liver | 2.6 | 3.3 | 4.9 | -2.2 | -2.2 | 1.7 | -2.0 | 0.0 |
| Compulsive drug intake | 2.5 | 2.5 | 5.7 | 1.8 | 2.4 | -0.7 | 1.2 | -1.3 |
| Delay discounting time to switch 0 sec | 2.4 | 3.7 | 5.7 | -1.8 | -0.7 | 2.3 | -2.0 | -2.4 |
| Lifetime Intake | 2.4 | 2.7 | 5.0 | -2.1 | -2.2 | 1.1 | -1.6 | 0.8 |
| Bone: trabecular number | 2.4 | 3.7 | 5.3 | -2.0 | -1.3 | 2.3 | -2.1 | -1.8 |
| Vertical activity count, locomotor time 2 | 2.4 | 2.6 | 3.6 | 1.9 | 1.5 | -1.8 | 1.8 | 0.8 |
| Locomotion in novel chamber | 2.4 | 3.0 | 6.4 | -1.5 | -2.5 | 0.2 | -1.0 | 2.3 |
| Glucose | 2.2 | 3.3 | 6.0 | -2.2 | -2.4 | 1.4 | -1.8 | 0.5 |
| Pavlov. Cond. magazine entry number | 2.2 | 2.7 | 7.5 | 0.9 | -0.4 | -1.8 | 1.3 | 2.7 |
| Extensor digitorum longus weight | 2.1 | 8.5 | 18.3 | 2.4 | 4.3 | -0.2 | 1.3 | -4.1 |
| Delay discounting water rate 6 sec | 2.1 | 3.1 | 5.1 | 1.5 | 0.5 | -2.1 | 1.8 | 2.2 |
| Bone volume | 2.1 | 3.6 | 5.2 | -1.9 | -1.1 | 2.3 | -2.1 | -1.9 |
| Bone: trabecular tissue density | 2.1 | 3.0 | 10.3 | 0.4 | -1.1 | -1.7 | 0.9 | 3.2 |
| Time to tail flick, vehicle, before self-admin | 2.1 | 2.2 | 3.4 | -1.6 | -0.9 | 1.8 | -1.4 | -1.5 |
| Time to tail flick, test, before self-admin | 2.1 | 2.0 | 2.9 | -1.7 | -1.2 | 1.6 | -1.7 | -0.8 |
| Seeking ratio, punishment vs. effort | 2.1 | 2.6 | 4.2 | 1.3 | 0.6 | -2.0 | 1.7 | 2.0 |
| BMI with tail | 2.0 | 6.4 | 13.5 | -1.9 | -0.2 | 2.9 | -2.5 | -3.7 |
| Intermittent access day 15 total locomotion | 2.0 | 2.2 | 4.8 | -1.4 | -2.2 | 0.3 | -1.0 | 1.7 |
| Bone: minimum diameter | 2.0 | 3.8 | 5.5 | -2.3 | -2.3 | 1.8 | -2.1 | -0.0 |
| Bone: stiffness | 2.0 | 3.2 | 4.6 | -1.8 | -0.7 | 2.1 | -1.8 | -2.1 |
| Reaction time premature initiations | 1.9 | 2.7 | 6.4 | 1.6 | 2.5 | -0.5 | 1.1 | -1.8 |
| Conditioned reinforcement - inactives | 1.9 | 2.1 | 6.1 | -0.8 | -1.9 | -0.5 | -0.3 | 2.5 |
| Bone: elastic work | 1.9 | 2.5 | 4.2 | 2.0 | 2.1 | -1.3 | 1.6 | -0.4 |
| Bone: trabecular thickness | 1.9 | 2.3 | 3.2 | -1.8 | -1.7 | 1.5 | -1.7 | -0.3 |
| Condit. Reinf. active responses | 1.8 | 2.5 | 3.4 | -1.8 | -1.4 | 1.8 | -1.8 | -0.8 |
| Condit. Reinf. lever reinforcers received | 1.8 | 2.6 | 3.4 | -1.8 | -1.3 | 1.8 | -1.8 | -1.1 |
| Pavlov. Cond. magazine entry latency | 1.8 | 2.1 | 5.7 | -0.8 | 0.3 | 1.6 | -1.1 | -2.4 |
| Delay disc. indifference point, 0s delay | 1.8 | 1.9 | 2.7 | -1.5 | -1.3 | 1.7 | -1.4 | -0.9 |
| Run reversals in cocaine runway, females | 1.8 | 1.8 | 3.1 | -1.1 | -0.3 | 1.6 | -1.5 | -1.7 |
| Short access day 1 total infusions | 1.7 | 1.8 | 3.2 | -1.6 | -1.8 | 0.9 | -1.4 | 0.7 |
| Locomotion velocity, session 3 | 1.7 | 2.0 | 2.7 | -1.6 | -1.1 | 1.6 | -1.6 | -1.0 |
| Stereotopy head waving duration, day 7 | 1.7 | 2.0 | 3.0 | -1.4 | -0.6 | 1.7 | -1.5 | -1.6 |
| Bone: maximum force | 1.7 | 3.0 | 5.9 | -1.4 | -0.4 | 2.1 | -1.6 | -2.4 |
| K content in liver | 1.7 | 1.7 | 3.1 | -1.1 | -0.2 | 1.5 | -1.3 | -1.8 |
| Sr content in liver | 1.7 | 1.6 | 3.1 | 1.4 | 1.8 | -0.8 | 1.2 | -0.7 |
| Retroperitoneal fat weight | 1.6 | 5.4 | 13.9 | -1.7 | -3.1 | -0.4 | -0.7 | 3.7 |
| Condit. Reinf. active minus inactive responses | 1.6 | 2.0 | 3.0 | -1.7 | -1.6 | 1.4 | -1.6 | -0.1 |
| Short access total infusions | 1.6 | 1.8 | 2.9 | -1.7 | -1.5 | 1.2 | -1.6 | -0.1 |
| Short access day 1 locomotion | 1.6 | 1.7 | 3.1 | -1.6 | -1.8 | 0.9 | -1.4 | 0.5 |
| Locomotion distance, session 1 | 1.6 | 2.1 | 2.9 | -1.5 | -0.8 | 1.7 | -1.6 | -1.5 |
| Soleus weight | 1.5 | 4.4 | 15.4 | 0.3 | -1.5 | -1.9 | 1.0 | 3.9 |
| Std. dev. time between licks in bursts | 1.5 | 1.8 | 2.8 | 1.6 | 1.7 | -1.3 | 1.4 | 0.1 |
| Stereotopy head waving bouts, day 3 | 1.5 | 1.8 | 2.8 | -1.7 | -1.4 | 1.4 | -1.4 | -0.4 |
| Total locomotion distance, hab. session 2 | 1.5 | 1.9 | 2.6 | -1.6 | -1.2 | 1.6 | -1.6 | -0.8 |
| Active lever presses in extinction session 6 | 1.5 | 1.4 | 2.8 | 1.4 | 1.7 | -1.1 | 1.1 | -0.2 |
| Length with tail | 1.4 | 5.1 | 10.8 | 2.5 | 3.3 | -1.1 | 2.0 | -1.9 |
| Condit. Reinf. active-inactive response ratio | 1.4 | 1.5 | 2.9 | -1.4 | -1.7 | 0.8 | -1.1 | 0.8 |
| Stereotopy head waving bouts, day 7 | 1.4 | 1.6 | 2.6 | -1.6 | -1.4 | 1.3 | -1.4 | -0.2 |
| Time in novel zone, hab. session 2 | 1.4 | 1.4 | 2.0 | -1.4 | -1.1 | 1.2 | -1.4 | -0.5 |
| Locomotion velocity, hab. session 2 | 1.4 | 1.9 | 2.7 | -1.6 | -1.4 | 1.5 | -1.6 | -0.5 |
| Bone: endosteal estimation | 1.4 | 3.1 | 5.7 | -2.1 | -2.4 | 1.3 | -1.8 | 0.7 |
| Bone: marrow area | 1.4 | 3.1 | 5.7 | -2.1 | -2.4 | 1.3 | -1.7 | 0.7 |
| Bone: maximum moment | 1.4 | 2.5 | 5.0 | -1.2 | -0.3 | 1.9 | -1.5 | -2.2 |
| Extinction: sum of active levers before priming | 1.4 | 1.4 | 5.0 | -0.0 | 0.8 | 1.1 | -0.5 | -2.2 |
| Pavlov. Cond. magazine entry latency | 1.3 | 1.6 | 2.2 | -1.5 | -1.3 | 1.4 | -1.5 | -0.6 |
| Bone: cortical thickness | 1.3 | 1.5 | 3.0 | 1.5 | 1.7 | -0.7 | 1.1 | -0.9 |
| Total heroin consumption | 1.3 | 1.5 | 3.9 | 0.8 | 1.7 | 0.2 | 0.3 | -2.0 |
| Latency to leave start box in cocaine runway | 1.3 | 1.4 | 1.9 | -1.4 | -1.2 | 1.3 | -1.3 | -0.5 |
| Parametrial fat weight | 1.2 | 2.4 | 4.6 | -1.8 | -2.2 | 0.9 | -1.5 | 1.0 |
| Indifference point function ln k | 1.2 | 1.7 | 5.4 | -0.6 | -1.6 | -0.5 | -0.1 | 2.3 |
| Indifference point function log k | 1.2 | 1.7 | 5.4 | -0.6 | -1.6 | -0.5 | -0.1 | 2.3 |
| Progressive ratio test 2 breakpoint | 1.2 | 1.3 | 4.5 | -0.4 | -1.2 | -0.7 | -0.0 | 2.1 |
| Locomotion velocity, session 7 | 1.2 | 1.3 | 1.7 | -1.3 | -1.0 | 1.3 | -1.3 | -0.7 |
| Rest time, locomotor task time 1 | 1.2 | 1.3 | 3.2 | 0.8 | -0.0 | -1.3 | 1.0 | 1.8 |
| Distance moved, locomotor task time 1 | 1.2 | 1.3 | 1.7 | -1.3 | -0.9 | 1.3 | -1.2 | -0.9 |
| Rest time, locomotor task time 2 | 1.2 | 1.4 | 2.9 | -1.3 | -1.7 | 0.7 | -0.9 | 0.9 |
| BMI without tail | 1.1 | 2.3 | 5.4 | -1.0 | -0.0 | 1.8 | -1.4 | -2.3 |
| Body weight | 1.1 | 4.4 | 15.0 | 0.6 | 2.4 | 1.1 | -0.2 | -3.9 |
| Epididymis fat weight | 1.1 | 2.5 | 6.4 | -1.2 | -2.1 | -0.3 | -0.4 | 2.5 |
| Tail length | 1.1 | 3.2 | 5.5 | 2.2 | 2.3 | -1.4 | 2.0 | -0.5 |
| Baseline Anxiety | 1.1 | 1.2 | 2.6 | 1.2 | 1.6 | -0.5 | 0.9 | -0.9 |
| Ambulatory time after self-admin | 1.1 | 1.3 | 2.0 | -1.3 | -1.4 | 1.1 | -1.2 | -0.1 |
| Length without tail | 1.0 | 2.1 | 4.5 | 1.4 | 2.1 | -0.3 | 0.8 | -1.8 |
| Intraocular pressure | 1.0 | 1.4 | 1.9 | 1.2 | 0.5 | -1.4 | 1.4 | 1.4 |
| Condit. Reinf. inactive responses | 1.0 | 1.2 | 2.3 | -0.9 | -0.2 | 1.3 | -1.1 | -1.5 |
| Intermitt. access day 15 inactive lever presses | 1.0 | 1.1 | 2.5 | -1.2 | -1.6 | 0.4 | -0.7 | 1.0 |
| Progressive ratio test 2 active lever presses | 1.0 | 1.1 | 2.6 | -0.8 | -1.4 | -0.1 | -0.5 | 1.6 |
| Short access total locomotion | 1.0 | 1.0 | 1.7 | -1.3 | -1.1 | 0.9 | -1.2 | 0.0 |
| Stereotopy head waving duration, day 3 | 1.0 | 1.2 | 2.1 | -1.4 | -1.5 | 0.9 | -1.0 | 0.3 |
| Total zone transitions, NPP test | 1.0 | 1.4 | 2.9 | -0.9 | -0.2 | 1.4 | -1.2 | -1.7 |
| Area under the delay curve | 1.0 | 1.1 | 1.7 | -1.3 | -1.0 | 1.2 | -1.1 | -0.6 |
| Run reversals in cocaine runway, males | 1.0 | 1.0 | 1.4 | 1.2 | 1.1 | -1.0 | 1.1 | 0.3 |
| Co content in liver | 1.0 | 1.2 | 1.7 | 1.1 | 0.6 | -1.3 | 1.1 | 1.1 |
| Light reinforcement 2 | 0.9 | 1.2 | 4.4 | -0.0 | -0.9 | -0.9 | 0.4 | 2.1 |
| Reaction time num false alarms | 0.9 | 1.2 | 1.7 | 1.3 | 1.1 | -1.1 | 1.3 | 0.5 |
| Reaction time premature initiation rate | 0.9 | 1.3 | 2.9 | 0.8 | 1.6 | 0.1 | 0.3 | -1.7 |
| Intermitt. access escalation Index | 0.9 | 0.8 | 2.9 | 0.0 | -0.8 | -0.7 | 0.4 | 1.7 |
| Post-drug Anxiety | 0.9 | 1.0 | 1.7 | 1.3 | 1.3 | -0.6 | 1.0 | -0.5 |
| Short access day 1 total inactive lever presses | 0.9 | 1.0 | 2.1 | -0.9 | -1.5 | 0.1 | -0.5 | 1.4 |
| Short access day 10 total locomotion | 0.9 | 1.0 | 1.7 | -1.3 | -1.2 | 0.9 | -1.1 | 0.1 |
| Time in familiar zone, hab. session 2 | 0.9 | 0.9 | 1.5 | 1.2 | 1.2 | -0.8 | 1.1 | -0.2 |
| Time to tail flick, vehicle, after self-admin | 0.9 | 0.9 | 3.3 | 0.0 | 0.8 | 0.7 | -0.5 | -1.8 |
| Bouts of movement, locomotor time 1 | 0.9 | 1.0 | 1.6 | 1.3 | 1.3 | -0.8 | 1.1 | -0.3 |
| Locomotion in novel chamber post-restriction | 0.9 | 1.1 | 3.5 | -0.4 | -1.3 | -0.3 | -0.1 | 1.9 |
| Se content in liver | 0.9 | 1.0 | 1.8 | -1.3 | -1.1 | 1.0 | -1.1 | -0.2 |
| Tibia length | 0.8 | 2.3 | 3.5 | 1.9 | 1.5 | -1.6 | 1.7 | 0.5 |
| Reaction time mean minus median | 0.8 | 1.0 | 3.2 | -0.1 | 0.8 | 1.0 | -0.7 | -1.8 |
| Reaction time num false alarms AUC | 0.8 | 1.2 | 2.1 | 1.3 | 1.4 | -0.8 | 1.2 | -0.3 |
| Reaction time trials on left | 0.8 | 1.2 | 2.0 | 1.3 | 1.4 | -0.9 | 1.1 | -0.2 |
| Reaction time trials completed | 0.8 | 1.2 | 2.0 | 1.3 | 1.4 | -0.9 | 1.1 | -0.2 |
| Saline control response | 0.8 | 1.1 | 3.5 | 0.4 | 1.3 | 0.4 | 0.1 | -1.9 |
| Condit. Reinf. lever presses | 0.8 | 1.1 | 2.1 | -0.8 | -0.2 | 1.3 | -1.0 | -1.4 |
| Intermittent access intake day 1-15 change | 0.8 | 0.8 | 2.5 | 0.2 | -0.5 | -0.8 | 0.5 | 1.6 |
| Delay discount exponential model param | 0.8 | 0.8 | 1.2 | 1.1 | 0.8 | -1.0 | 1.0 | 0.5 |
| Delay discount hyperbolic model param | 0.8 | 0.8 | 1.2 | 1.1 | 0.8 | -1.0 | 1.0 | 0.6 |
| Vertical activity count, locomotor time 1 | 0.8 | 0.9 | 1.9 | -1.2 | -1.4 | 0.6 | -0.6 | 0.5 |
| Latency to leave start box in cocaine runway, F | 0.8 | 0.9 | 1.2 | -1.1 | -0.9 | 1.1 | -1.1 | -0.6 |
| Right kidney weight | 0.7 | 2.1 | 4.4 | 1.1 | 0.2 | -1.7 | 1.3 | 2.1 |
| Indifference point AUC | 0.7 | 0.9 | 1.7 | 1.1 | 1.3 | -0.5 | 0.8 | -0.7 |
| Delay discounting total patch changes 12 sec | 0.7 | 0.9 | 2.4 | 0.7 | 1.2 | 0.1 | 0.4 | -1.6 |
| Delay discounting water rate 18 sec | 0.7 | 0.9 | 3.2 | 0.3 | -0.3 | -1.0 | 0.6 | 1.8 |
| Reaction time number correct | 0.7 | 1.0 | 1.6 | 1.2 | 1.3 | -0.8 | 1.0 | -0.1 |
| Reaction time trials correct on left | 0.7 | 1.0 | 1.6 | 1.2 | 1.3 | -0.8 | 1.0 | -0.1 |
| Reaction time omissions | 0.7 | 0.9 | 2.0 | 0.8 | 1.4 | 0.1 | 0.3 | -1.4 |
| Social response proportion | 0.7 | 0.7 | 1.7 | -0.4 | 0.2 | 0.9 | -0.9 | -1.3 |
| Pavlov. Cond. change in total contacts | 0.7 | 0.9 | 1.4 | -1.0 | -0.5 | 1.2 | -1.0 | -1.0 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.7 | 0.9 | 2.4 | -0.6 | 0.1 | 1.1 | -0.8 | -1.5 |
| Locomotion velocity, session 2 | 0.7 | 0.9 | 2.3 | 0.6 | 1.3 | 0.1 | 0.2 | -1.5 |
| Degree of sensitization stereotypy | 0.7 | 0.7 | 1.1 | -0.9 | -0.4 | 1.1 | -0.9 | -0.9 |
| Pavlov. Cond. change in total contacts | 0.7 | 0.7 | 1.2 | -1.0 | -1.1 | 0.7 | -0.9 | 0.2 |
| Bone: trabecular spacing | 0.7 | 0.9 | 1.5 | 0.9 | 0.5 | -1.2 | 1.1 | 1.0 |
| Delta time in closed arm before/after self-admin | 0.7 | 0.7 | 1.6 | 0.9 | 1.3 | -0.6 | 0.7 | -0.5 |
| Delay disc. indifference point, 16s delay | 0.7 | 0.7 | 1.5 | -0.9 | -1.2 | 0.2 | -0.4 | 0.9 |
| Total resting periods, locomotor time 1 | 0.7 | 0.8 | 1.3 | 1.2 | 1.0 | -0.8 | 0.9 | -0.0 |
| Heart weight | 0.6 | 0.8 | 2.0 | -0.8 | -1.4 | 0.2 | -0.5 | 1.1 |
| Times rat made contact with spout | 0.6 | 0.7 | 1.3 | -0.6 | -0.1 | 1.0 | -0.8 | -1.1 |
| Delay discounting total patch changes 24 sec | 0.6 | 0.7 | 1.4 | 0.9 | 1.2 | -0.5 | 0.8 | -0.6 |
| Reaction time mean minus median AUC | 0.6 | 0.7 | 1.7 | 0.6 | 1.2 | 0.2 | 0.1 | -1.3 |
| Median of all reaction times | 0.6 | 0.8 | 1.2 | -1.1 | -1.1 | 0.9 | -1.0 | -0.2 |
| Reaction time trials AUC | 0.6 | 0.8 | 1.4 | 1.1 | 1.2 | -0.8 | 1.0 | -0.1 |
| Pavlov. Cond. index score | 0.6 | 0.8 | 1.8 | -0.6 | -0.0 | 1.0 | -0.7 | -1.3 |
| Intermittent access intake escalation | 0.6 | 0.6 | 1.8 | -0.2 | -0.9 | -0.4 | 0.1 | 1.3 |
| Locomotion distance, session 2 | 0.6 | 0.8 | 2.1 | -0.6 | 0.2 | 1.0 | -0.9 | -1.4 |
| Novelty place preference | 0.6 | 0.6 | 0.9 | -0.9 | -0.7 | 0.9 | -0.8 | -0.5 |
| Time in novel zone, NPP test | 0.6 | 0.6 | 0.9 | -0.9 | -0.7 | 0.9 | -0.8 | -0.5 |
| Pavlov. Cond. intertrial magazine entries | 0.6 | 0.7 | 1.0 | 0.8 | 0.4 | -1.0 | 1.0 | 0.9 |
| Bone: cortical area | 0.6 | 0.9 | 1.4 | 1.2 | 1.2 | -0.8 | 1.0 | -0.2 |
| Breakpoint value in progressive ratio session | 0.6 | 0.7 | 2.4 | 0.3 | 1.0 | 0.4 | -0.1 | -1.6 |
| Delay disc. indifference point, 2s delay | 0.6 | 0.7 | 1.1 | -1.1 | -1.0 | 0.8 | -0.9 | 0.0 |
| Distance moved, locomotor task time 2 | 0.6 | 0.7 | 1.2 | 1.0 | 1.1 | -0.7 | 0.9 | -0.3 |
| Seeking ratio, delayed vs. immediate footshock | 0.6 | 0.7 | 1.1 | -1.0 | -0.7 | 1.1 | -0.8 | -0.8 |
| Cd content in liver | 0.6 | 0.6 | 2.2 | 0.1 | -0.7 | -0.6 | 0.3 | 1.5 |
| Left kidney weight | 0.5 | 1.3 | 4.1 | 0.4 | -0.4 | -1.2 | 0.8 | 2.0 |
| Locomotor testing distance | 0.5 | 0.8 | 2.3 | 0.5 | -0.2 | -0.9 | 0.6 | 1.5 |
| Locomotor testing rearing | 0.5 | 0.8 | 1.6 | -0.9 | -1.3 | 0.4 | -0.8 | 0.7 |
| Reaction time mean AUC | 0.5 | 0.6 | 0.8 | -0.9 | -0.8 | 0.8 | -0.9 | -0.3 |
| Cocaine response after cond. not corrected | 0.5 | 0.5 | 0.8 | -0.9 | -0.8 | 0.7 | -0.8 | -0.1 |
| Pavlov. Cond. latency score | 0.5 | 0.6 | 1.3 | -0.5 | -0.0 | 0.9 | -0.6 | -1.2 |
| Pavlov. Cond. intertrial magazine entries | 0.5 | 0.7 | 2.2 | -0.0 | -0.7 | -0.7 | 0.4 | 1.5 |
| Conditioned reinforcement - actives | 0.5 | 0.5 | 0.9 | 0.6 | 0.2 | -0.9 | 0.6 | 0.9 |
| Intermitt. access day 1 inactive lever presses | 0.5 | 0.6 | 1.3 | -0.6 | -1.0 | -0.0 | -0.3 | 1.1 |
| Progressive ratio test 1 active lever presses | 0.5 | 0.5 | 1.6 | -0.3 | -0.7 | -0.4 | -0.1 | 1.3 |
| Total sessions with >9 infusions | 0.5 | 0.6 | 1.0 | -0.9 | -1.0 | 0.3 | -0.8 | 0.5 |
| Short access day 10 total inactive lever presses | 0.5 | 0.6 | 1.4 | -0.7 | -1.2 | 0.1 | -0.3 | 0.9 |
| Context. condit. distance diff. score | 0.5 | 0.6 | 1.4 | -0.8 | -1.2 | 0.3 | -0.5 | 0.8 |
| Condit. Reinf. active minus inactive responses | 0.5 | 0.5 | 0.7 | -0.8 | -0.4 | 0.8 | -0.9 | -0.6 |
| Novel to familiar place preference ratio | 0.5 | 0.5 | 0.7 | -0.8 | -0.4 | 0.8 | -0.7 | -0.7 |
| Bone: final force | 0.5 | 0.8 | 3.0 | -0.0 | 0.7 | 0.7 | -0.2 | -1.7 |
| Mean time between licks in bursts | 0.4 | 0.5 | 1.2 | 0.6 | 1.1 | -0.0 | 0.4 | -1.0 |
| Water consumed over 24 hours | 0.4 | 0.4 | 1.3 | -0.4 | 0.1 | 0.7 | -0.4 | -1.1 |
| Delay discounting total patch changes 6 sec | 0.4 | 0.7 | 1.9 | -0.5 | 0.1 | 1.0 | -0.6 | -1.4 |
| Locomotor activity | 0.4 | 0.7 | 1.9 | 0.5 | -0.1 | -0.9 | 0.6 | 1.4 |
| Intermittent access intake escalation 2 | 0.4 | 0.4 | 1.1 | 0.2 | -0.4 | -0.6 | 0.4 | 1.1 |
| Progressive ratio test 1 breakpoint | 0.4 | 0.5 | 1.7 | -0.1 | -0.6 | -0.5 | 0.1 | 1.3 |
| Locomotion velocity, session 8 | 0.4 | 0.5 | 1.6 | 0.4 | 0.9 | 0.3 | 0.1 | -1.3 |
| Locomotion distance, session 8 | 0.4 | 0.6 | 0.9 | -0.9 | -0.9 | 0.6 | -0.8 | 0.1 |
| Time in familiar zone, hab. session 1 | 0.4 | 0.4 | 0.8 | -0.7 | -0.9 | 0.5 | -0.7 | 0.3 |
| Total locomotion distance, NPP test | 0.4 | 0.6 | 0.9 | -0.9 | -0.8 | 0.8 | -0.9 | -0.3 |
| Bone: cortical tissue density | 0.4 | 0.5 | 1.1 | 0.8 | 1.0 | -0.3 | 0.6 | -0.6 |
| Bone: final moment | 0.4 | 0.7 | 2.6 | 0.1 | 0.7 | 0.6 | -0.2 | -1.6 |
| Bone: periosteal perimeter | 0.4 | 0.6 | 0.9 | -0.9 | -0.9 | 0.8 | -0.8 | -0.0 |
| Delta time to tail flick, vehicle, before/after SA | 0.4 | 0.4 | 0.7 | 0.7 | 0.8 | -0.2 | 0.1 | -0.8 |
| Delay disc. indifference point, 4s delay | 0.4 | 0.4 | 0.6 | -0.7 | -0.5 | 0.8 | -0.8 | -0.5 |
| Delay disc. indifference point, 8s delay | 0.4 | 0.4 | 0.6 | -0.8 | -0.4 | 0.7 | -0.6 | -0.6 |
| Weight adjusted by age | 0.4 | 0.5 | 1.3 | 0.4 | 1.0 | 0.1 | 0.1 | -1.2 |
| Mn content in liver | 0.4 | 0.5 | 1.6 | 0.2 | 0.8 | 0.4 | -0.2 | -1.3 |
| Liver weight, right | 0.3 | 0.5 | 0.7 | 0.7 | 0.5 | -0.9 | 0.7 | 0.7 |
| Light reinforcement 1 | 0.3 | 0.6 | 1.8 | 0.1 | -0.5 | -0.7 | 0.5 | 1.3 |
| Reaction time mean | 0.3 | 0.5 | 0.6 | -0.8 | -0.7 | 0.7 | -0.8 | -0.4 |
| Reaction time false alarm rate | 0.3 | 0.4 | 0.6 | 0.8 | 0.7 | -0.6 | 0.8 | 0.1 |
| Std. dev. reaction times | 0.3 | 0.4 | 1.0 | -0.2 | 0.3 | 0.7 | -0.6 | -1.0 |
| Social responses | 0.3 | 0.4 | 1.0 | 0.8 | 1.0 | -0.3 | 0.2 | -0.4 |
| Pavlov. Cond. response bias | 0.3 | 0.4 | 1.2 | -0.2 | 0.3 | 0.7 | -0.5 | -1.1 |
| Intermittent access standard deviation | 0.3 | 0.3 | 0.9 | -0.2 | -0.6 | -0.3 | 0.1 | 1.0 |
| Degree of sensitization distance | 0.3 | 0.3 | 0.6 | -0.4 | -0.1 | 0.6 | -0.5 | -0.7 |
| Condit. Reinf. active-inactive response ratio | 0.3 | 0.3 | 0.5 | -0.7 | -0.6 | 0.6 | -0.7 | -0.2 |
| Incentive salience index mean | 0.3 | 0.4 | 0.6 | -0.6 | -0.3 | 0.7 | -0.8 | -0.6 |
| Total locomotion distance, hab. session 1 | 0.3 | 0.4 | 0.8 | -0.6 | -0.9 | 0.3 | -0.6 | 0.6 |
| Bone: cortical apparent density | 0.3 | 0.4 | 0.8 | 0.7 | 0.9 | -0.3 | 0.5 | -0.6 |
| Bone: tissue strength | 0.3 | 0.3 | 0.4 | -0.6 | -0.6 | 0.4 | -0.6 | 0.1 |
| Delay disc. indifference point, 24s delay | 0.3 | 0.3 | 0.4 | 0.6 | 0.6 | -0.5 | 0.7 | 0.1 |
| Bouts of movement, locomotor time 2 | 0.3 | 0.3 | 0.9 | 0.6 | 0.9 | -0.2 | 0.3 | -0.5 |
| Na content in liver | 0.3 | 0.4 | 0.5 | 0.7 | 0.6 | -0.6 | 0.7 | 0.2 |
| Zn content in liver | 0.3 | 0.4 | 0.7 | 0.5 | 0.9 | -0.0 | 0.3 | -0.8 |
| Food consumed during 24 hour testing period | 0.2 | 0.3 | 0.7 | 0.3 | -0.1 | -0.6 | 0.5 | 0.8 |
| Social time | 0.2 | 0.3 | 0.7 | 0.2 | 0.7 | 0.2 | -0.2 | -0.9 |
| Cocaine response before conditioning | 0.2 | 0.2 | 0.3 | -0.5 | -0.2 | 0.5 | -0.6 | -0.5 |
| Incentive Sensitization - Breakpoint | 0.2 | 0.2 | 0.5 | -0.4 | -0.7 | 0.0 | -0.3 | 0.6 |
| Progressive ratio test 1 inactive lever presses | 0.2 | 0.2 | 0.4 | -0.5 | -0.7 | 0.1 | -0.5 | 0.5 |
| Number of responses in last shaping day | 0.2 | 0.2 | 0.6 | -0.0 | -0.3 | -0.4 | -0.0 | 0.8 |
| Total zone transitions, hab. session 1 | 0.2 | 0.3 | 0.8 | -0.2 | 0.3 | 0.5 | -0.4 | -0.9 |
| Locomotion velocity, NPP test | 0.2 | 0.4 | 0.5 | -0.7 | -0.6 | 0.6 | -0.7 | -0.2 |
| Delta time in open arm before/after self-admin | 0.2 | 0.2 | 0.2 | -0.5 | -0.4 | 0.2 | -0.5 | 0.2 |
| Diff in mean of infusions in LGA sessions | 0.2 | 0.2 | 0.4 | 0.5 | 0.6 | -0.2 | 0.5 | -0.4 |
| Time in closed arm before self-admin | 0.2 | 0.2 | 0.4 | -0.6 | -0.6 | 0.4 | -0.5 | 0.2 |
| Time in closed arm after self-admin | 0.2 | 0.2 | 0.3 | 0.5 | 0.5 | -0.4 | 0.4 | 0.1 |
| Time in open arm before self-admin | 0.2 | 0.3 | 0.5 | 0.6 | 0.7 | -0.3 | 0.5 | -0.4 |
| Ambulatory time before self-admin | 0.2 | 0.2 | 0.4 | -0.4 | -0.4 | 0.6 | -0.5 | -0.5 |
| Change in fecal boli incidents, locomotor task | 0.2 | 0.2 | 0.5 | -0.3 | 0.1 | 0.5 | -0.3 | -0.7 |
| Number of licking bursts | 0.1 | 0.1 | 0.3 | -0.6 | -0.3 | 0.4 | -0.4 | -0.3 |
| Indifference point 0 sec | 0.1 | 0.1 | 0.3 | -0.3 | -0.6 | 0.1 | -0.2 | 0.5 |
| Delay discounting total patch changes 0 sec | 0.1 | 0.1 | 0.3 | 0.3 | 0.0 | -0.4 | 0.4 | 0.5 |
| Delay discounting total patch changes 18 sec | 0.1 | 0.1 | 0.5 | -0.0 | 0.1 | 0.4 | -0.1 | -0.7 |
| Cocaine response after cond. corrected | 0.1 | 0.1 | 0.2 | -0.4 | -0.5 | 0.2 | -0.2 | 0.2 |
| Incentive Sensitization - Responses | 0.1 | 0.1 | 0.3 | -0.4 | -0.6 | 0.1 | -0.4 | 0.4 |
| Locomotion distance, session 3 | 0.1 | 0.1 | 0.2 | -0.4 | -0.3 | 0.4 | -0.5 | -0.2 |
| Locomotion distance, session 7 | 0.1 | 0.2 | 0.5 | -0.2 | 0.1 | 0.5 | -0.4 | -0.7 |
| Condit. Reinf. active responses | 0.1 | 0.1 | 0.1 | -0.3 | -0.2 | 0.3 | -0.4 | -0.1 |
| Condit. Reinf. inactive responses | 0.1 | 0.1 | 0.1 | 0.3 | -0.0 | -0.3 | 0.1 | 0.3 |
| Time in novel zone, hab. session 1 | 0.1 | 0.1 | 0.1 | 0.3 | 0.4 | -0.2 | 0.3 | -0.0 |
| Locomotion velocity, hab. session 1 | 0.1 | 0.1 | 0.2 | -0.3 | -0.4 | 0.1 | -0.3 | 0.3 |
| Pavlov. Cond. lever latency | 0.1 | 0.1 | 0.3 | 0.3 | -0.0 | -0.4 | 0.4 | 0.6 |
| Pavlov. Cond. index score | 0.1 | 0.1 | 0.1 | -0.3 | -0.4 | 0.2 | -0.3 | 0.1 |
| Pavlov. Cond. latency score | 0.1 | 0.2 | 0.3 | -0.5 | -0.5 | 0.4 | -0.5 | -0.1 |
| Pavlov. Cond. lever contacts | 0.1 | 0.1 | 0.2 | -0.3 | -0.2 | 0.3 | -0.4 | -0.2 |
| Bone: cortical porosity | 0.1 | 0.1 | 0.1 | -0.3 | -0.3 | 0.3 | -0.4 | -0.2 |
| Bone: cortical porosity | 0.1 | 0.1 | 0.3 | 0.1 | 0.3 | 0.2 | -0.1 | -0.5 |
| Bone: maximum diameter | 0.1 | 0.1 | 0.4 | 0.2 | -0.1 | -0.4 | 0.3 | 0.6 |
| Bone: periosteal estimation | 0.1 | 0.2 | 0.4 | -0.5 | -0.7 | 0.2 | -0.4 | 0.3 |
| Distance traveled before self-admin | 0.1 | 0.1 | 0.2 | -0.1 | -0.1 | 0.4 | -0.3 | -0.5 |
| Delta ambulatory time before/after self-admin | 0.1 | 0.1 | 0.2 | 0.2 | 0.4 | -0.2 | 0.3 | -0.0 |
| Time to tail flick, test, after self-admin | 0.1 | 0.1 | 0.2 | 0.1 | 0.3 | -0.1 | 0.4 | -0.2 |
| Time >=10cm from walls, locomotor time 2 | 0.1 | 0.1 | 0.3 | 0.3 | -0.1 | -0.5 | 0.2 | 0.6 |
| Total resting periods, locomotor time 2 | 0.1 | 0.1 | 0.3 | 0.3 | 0.5 | 0.0 | 0.0 | -0.4 |
| Food seeking constrained by brief footshock | 0.1 | 0.1 | 0.5 | -0.0 | 0.4 | 0.3 | 0.0 | -0.7 |
| Latency to leave start box in cocaine runway, M | 0.1 | 0.0 | 0.1 | -0.3 | -0.3 | 0.2 | -0.2 | 0.0 |
| Cu content in liver | 0.1 | 0.1 | 0.3 | 0.4 | 0.5 | -0.3 | 0.3 | -0.2 |
| Liver weight, left | 0.0 | 0.1 | 0.2 | -0.1 | -0.3 | -0.1 | 0.1 | 0.4 |
| Mean num. licks in bursts | 0.0 | 0.1 | 0.1 | -0.0 | -0.1 | 0.3 | -0.3 | -0.3 |
| Pavlov. Cond. lever latency | 0.0 | 0.0 | 0.1 | 0.1 | 0.1 | -0.3 | 0.2 | 0.2 |
| Pavlov. Cond. lever contacts | 0.0 | 0.1 | 0.1 | 0.4 | 0.3 | -0.2 | 0.2 | 0.0 |
| Cocaine induced anxiety | 0.0 | 0.0 | 0.0 | 0.2 | -0.2 | -0.1 | 0.0 | 0.1 |
| Locomotion velocity, session 1 | 0.0 | 0.0 | 0.0 | -0.1 | -0.1 | 0.1 | -0.1 | -0.1 |
| Condit. Reinf. lever presses | 0.0 | 0.0 | 0.1 | 0.3 | 0.2 | -0.2 | 0.1 | 0.0 |
| Pavlov. Cond. magazine entry number | 0.0 | 0.0 | 0.1 | 0.0 | 0.2 | 0.1 | -0.0 | -0.3 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.0 | 0.0 | 0.1 | -0.2 | -0.3 | 0.2 | -0.3 | 0.0 |
| Pavlov. Cond. response bias | 0.0 | 0.1 | 0.1 | -0.2 | -0.3 | 0.1 | -0.2 | 0.1 |
| Distance traveled after self-admin | 0.0 | 0.0 | 0.1 | -0.1 | -0.2 | 0.3 | -0.2 | -0.2 |
| Delta distance traveled before/after self-admin | 0.0 | 0.0 | 0.0 | 0.0 | 0.1 | -0.1 | 0.1 | 0.1 |
| Time in open arm after self-admin | 0.0 | 0.0 | 0.1 | 0.3 | 0.2 | -0.2 | 0.2 | 0.1 |
| Fecal boli incidents, locomotor time 1 | 0.0 | 0.0 | 0.1 | -0.2 | -0.0 | -0.0 | -0.1 | 0.2 |
| Fe content in liver | 0.0 | 0.0 | 0.0 | 0.2 | 0.1 | 0.0 | -0.1 | -0.2 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.