Chka

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	intron excision ratio	chr1:201091617:201104058	0.02	0.02	7.9e-03	0.01	0.03	0.03	0.02	1.8e-02	1.5e-03	1.4e-03	3.6e-03
2	IL	isoform ratio	ENSRNOT00000023020	0.17	0.12	7.8e-03	0.1	0	0.05	0.05	2.4e-03	2.7e-01	2.5e-02	2.2e-02
3	Liver	isoform ratio	ENSRNOT00000022824	0.05	0.03	8.8e-06	0.03	0.04	0.03	0.03	3.5e-04	7.0e-05	4.7e-04	3.9e-04
4	Liver	isoform ratio	ENSRNOT00000096831	0.03	0.03	5.7e-03	0	0	0.01	0	1.9e-01	7.3e-02	2.6e-02	9.4e-02
5	PL	mRNA stability	ENSRNOG00000016791	0.05	0.04	1.3e-03	0.01	0.03	0.02	0.02	8.0e-02	4.4e-03	1.5e-02	1.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
BMI with tail	2.0	6.4	13.5	-1.9	-0.2	2.9	-2.5	-3.7
BMI without tail	1.1	2.3	5.4	-1.0	-0.0	1.8	-1.4	-2.3
Body weight	1.1	4.4	15.0	0.6	2.4	1.1	-0.2	-3.9
Epididymis fat weight	1.1	2.5	6.4	-1.2	-2.1	-0.3	-0.4	2.5
Glucose	2.2	3.3	6.0	-2.2	-2.4	1.4	-1.8	0.5
Heart weight	0.6	0.8	2.0	-0.8	-1.4	0.2	-0.5	1.1
Left kidney weight	0.5	1.3	4.1	0.4	-0.4	-1.2	0.8	2.0
Right kidney weight	0.7	2.1	4.4	1.1	0.2	-1.7	1.3	2.1
Tail length	1.1	3.2	5.5	2.2	2.3	-1.4	2.0	-0.5
Length with tail	1.4	5.1	10.8	2.5	3.3	-1.1	2.0	-1.9
Length without tail	1.0	2.1	4.5	1.4	2.1	-0.3	0.8	-1.8
Liver weight, left	0.0	0.1	0.2	-0.1	-0.3	-0.1	0.1	0.4
Liver weight, right	0.3	0.5	0.7	0.7	0.5	-0.9	0.7	0.7
Parametrial fat weight	1.2	2.4	4.6	-1.8	-2.2	0.9	-1.5	1.0
Retroperitoneal fat weight	1.6	5.4	13.9	-1.7	-3.1	-0.4	-0.7	3.7
Intraocular pressure	1.0	1.4	1.9	1.2	0.5	-1.4	1.4	1.4
Extensor digitorum longus weight	2.1	8.5	18.3	2.4	4.3	-0.2	1.3	-4.1
Soleus weight	1.5	4.4	15.4	0.3	-1.5	-1.9	1.0	3.9
Tibialis anterior weight	4.6	15.9	34.5	4.4	5.9	-2.1	3.3	-3.1
Tibia length	0.8	2.3	3.5	1.9	1.5	-1.6	1.7	0.5
Number of licking bursts	0.1	0.1	0.3	-0.6	-0.3	0.4	-0.4	-0.3
Food consumed during 24 hour testing period	0.2	0.3	0.7	0.3	-0.1	-0.6	0.5	0.8
Times rat made contact with spout	0.6	0.7	1.3	-0.6	-0.1	1.0	-0.8	-1.1
Mean time between licks in bursts	0.4	0.5	1.2	0.6	1.1	-0.0	0.4	-1.0
Mean num. licks in bursts	0.0	0.1	0.1	-0.0	-0.1	0.3	-0.3	-0.3
Std. dev. time between licks in bursts	1.5	1.8	2.8	1.6	1.7	-1.3	1.4	0.1
Water consumed over 24 hours	0.4	0.4	1.3	-0.4	0.1	0.7	-0.4	-1.1
Indifference point 0 sec	0.1	0.1	0.3	-0.3	-0.6	0.1	-0.2	0.5
Indifference point AUC	0.7	0.9	1.7	1.1	1.3	-0.5	0.8	-0.7
Indifference point function ln k	1.2	1.7	5.4	-0.6	-1.6	-0.5	-0.1	2.3
Indifference point function log k	1.2	1.7	5.4	-0.6	-1.6	-0.5	-0.1	2.3
Delay discounting total patch changes 0 sec	0.1	0.1	0.3	0.3	0.0	-0.4	0.4	0.5
Delay discounting total patch changes 12 sec	0.7	0.9	2.4	0.7	1.2	0.1	0.4	-1.6
Delay discounting total patch changes 18 sec	0.1	0.1	0.5	-0.0	0.1	0.4	-0.1	-0.7
Delay discounting total patch changes 24 sec	0.6	0.7	1.4	0.9	1.2	-0.5	0.8	-0.6
Delay discounting total patch changes 6 sec	0.4	0.7	1.9	-0.5	0.1	1.0	-0.6	-1.4
Delay discounting time to switch 0 sec	2.4	3.7	5.7	-1.8	-0.7	2.3	-2.0	-2.4
Delay discounting water rate 0 sec	3.6	5.7	12.7	1.8	0.2	-2.8	2.2	3.6
Delay discounting water rate 12 sec	4.3	6.4	16.5	1.6	-0.2	-2.9	2.1	4.1
Delay discounting water rate 18 sec	0.7	0.9	3.2	0.3	-0.3	-1.0	0.6	1.8
Delay discounting water rate 24 sec	2.6	3.6	6.7	1.6	0.5	-2.2	1.8	2.6
Delay discounting water rate 6 sec	2.1	3.1	5.1	1.5	0.5	-2.1	1.8	2.2
Locomotor activity	0.4	0.7	1.9	0.5	-0.1	-0.9	0.6	1.4
Locomotor testing distance	0.5	0.8	2.3	0.5	-0.2	-0.9	0.6	1.5
Locomotor testing rearing	0.5	0.8	1.6	-0.9	-1.3	0.4	-0.8	0.7
Light reinforcement 1	0.3	0.6	1.8	0.1	-0.5	-0.7	0.5	1.3
Light reinforcement 2	0.9	1.2	4.4	-0.0	-0.9	-0.9	0.4	2.1
Reaction time number correct	0.7	1.0	1.6	1.2	1.3	-0.8	1.0	-0.1
Reaction time mean minus median	0.8	1.0	3.2	-0.1	0.8	1.0	-0.7	-1.8
Reaction time mean minus median AUC	0.6	0.7	1.7	0.6	1.2	0.2	0.1	-1.3
Reaction time num false alarms	0.9	1.2	1.7	1.3	1.1	-1.1	1.3	0.5
Reaction time num false alarms AUC	0.8	1.2	2.1	1.3	1.4	-0.8	1.2	-0.3
Reaction time trials correct on left	0.7	1.0	1.6	1.2	1.3	-0.8	1.0	-0.1
Reaction time trials on left	0.8	1.2	2.0	1.3	1.4	-0.9	1.1	-0.2
Reaction time mean	0.3	0.5	0.6	-0.8	-0.7	0.7	-0.8	-0.4
Reaction time mean AUC	0.5	0.6	0.8	-0.9	-0.8	0.8	-0.9	-0.3
Median of all reaction times	0.6	0.8	1.2	-1.1	-1.1	0.9	-1.0	-0.2
Reaction time omissions	0.7	0.9	2.0	0.8	1.4	0.1	0.3	-1.4
Reaction time false alarm rate	0.3	0.4	0.6	0.8	0.7	-0.6	0.8	0.1
Reaction time premature initiation rate	0.9	1.3	2.9	0.8	1.6	0.1	0.3	-1.7
Reaction time premature initiations	1.9	2.7	6.4	1.6	2.5	-0.5	1.1	-1.8
Std. dev. reaction times	0.3	0.4	1.0	-0.2	0.3	0.7	-0.6	-1.0
Reaction time trials completed	0.8	1.2	2.0	1.3	1.4	-0.9	1.1	-0.2
Reaction time trials AUC	0.6	0.8	1.4	1.1	1.2	-0.8	1.0	-0.1
Social response proportion	0.7	0.7	1.7	-0.4	0.2	0.9	-0.9	-1.3
Social responses	0.3	0.4	1.0	0.8	1.0	-0.3	0.2	-0.4
Social time	0.2	0.3	0.7	0.2	0.7	0.2	-0.2	-0.9
Conditioned locomotion	2.8	3.3	5.7	2.2	2.4	-1.5	1.8	-0.4
Cocaine response after cond. corrected	0.1	0.1	0.2	-0.4	-0.5	0.2	-0.2	0.2
Cocaine response after cond. not corrected	0.5	0.5	0.8	-0.9	-0.8	0.7	-0.8	-0.1
Cocaine response before conditioning	0.2	0.2	0.3	-0.5	-0.2	0.5	-0.6	-0.5
Saline control response	0.8	1.1	3.5	0.4	1.3	0.4	0.1	-1.9
Condit. Reinf. active minus inactive responses	1.6	2.0	3.0	-1.7	-1.6	1.4	-1.6	-0.1
Condit. Reinf. active-inactive response ratio	1.4	1.5	2.9	-1.4	-1.7	0.8	-1.1	0.8
Condit. Reinf. active responses	1.8	2.5	3.4	-1.8	-1.4	1.8	-1.8	-0.8
Condit. Reinf. inactive responses	1.0	1.2	2.3	-0.9	-0.2	1.3	-1.1	-1.5
Condit. Reinf. lever presses	0.8	1.1	2.1	-0.8	-0.2	1.3	-1.0	-1.4
Condit. Reinf. lever reinforcers received	1.8	2.6	3.4	-1.8	-1.3	1.8	-1.8	-1.1
Pavlov. Cond. lever latency	0.0	0.0	0.1	0.1	0.1	-0.3	0.2	0.2
Pavlov. Cond. magazine entry latency	1.8	2.1	5.7	-0.8	0.3	1.6	-1.1	-2.4
Pavlov. Cond. change in total contacts	0.7	0.9	1.4	-1.0	-0.5	1.2	-1.0	-1.0
Pavlov. Cond. index score	0.6	0.8	1.8	-0.6	-0.0	1.0	-0.7	-1.3
Pavlov. Cond. latency score	0.5	0.6	1.3	-0.5	-0.0	0.9	-0.6	-1.2
Pavlov. Cond. lever contacts	0.0	0.1	0.1	0.4	0.3	-0.2	0.2	0.0
Pavlov. Cond. magazine entry number	2.2	2.7	7.5	0.9	-0.4	-1.8	1.3	2.7
Pavlov. Cond. intertrial magazine entries	0.5	0.7	2.2	-0.0	-0.7	-0.7	0.4	1.5
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	2.4	-0.6	0.1	1.1	-0.8	-1.5
Pavlov. Cond. response bias	0.3	0.4	1.2	-0.2	0.3	0.7	-0.5	-1.1
Conditioned reinforcement - actives	0.5	0.5	0.9	0.6	0.2	-0.9	0.6	0.9
Conditioned reinforcement - inactives	1.9	2.1	6.1	-0.8	-1.9	-0.5	-0.3	2.5
Conditioned locomotion	3.4	4.1	14.3	0.3	-1.4	-1.8	0.8	3.8
Intermittent access intake day 1-15 change	0.8	0.8	2.5	0.2	-0.5	-0.8	0.5	1.6
Intermittent access intake escalation	0.6	0.6	1.8	-0.2	-0.9	-0.4	0.1	1.3
Intermittent access intake escalation 2	0.4	0.4	1.1	0.2	-0.4	-0.6	0.4	1.1
Intermitt. access day 1 inactive lever presses	0.5	0.6	1.3	-0.6	-1.0	-0.0	-0.3	1.1
Intermitt. access day 15 inactive lever presses	1.0	1.1	2.5	-1.2	-1.6	0.4	-0.7	1.0
Intermitt. access escalation Index	0.9	0.8	2.9	0.0	-0.8	-0.7	0.4	1.7
Intermittent access day 1 total infusions	5.0	5.7	9.2	-3.0	-3.0	2.0	-2.5	0.4
Intermittent access day 15 total infusions	3.4	3.8	8.4	-2.0	-2.9	0.5	-1.3	2.2
Intermittent access terminal intake (last 3 days)	3.2	3.5	7.4	-2.2	-2.7	0.9	-1.5	1.5
Intermittent access total infusions	2.8	3.1	6.0	-2.2	-2.5	1.1	-1.7	0.9
Intermittent access day 1 locomotion	3.3	3.4	5.4	-2.3	-2.1	1.7	-2.1	-0.1
Intermittent access day 15 total locomotion	2.0	2.2	4.8	-1.4	-2.2	0.3	-1.0	1.7
Intermittent access total locomotion	4.3	4.9	9.9	-2.6	-3.1	1.3	-2.1	1.3
Intermittent access standard deviation	0.3	0.3	0.9	-0.2	-0.6	-0.3	0.1	1.0
Cocaine induced anxiety	0.0	0.0	0.0	0.2	-0.2	-0.1	0.0	0.1
Post-drug Anxiety	0.9	1.0	1.7	1.3	1.3	-0.6	1.0	-0.5
Baseline Anxiety	1.1	1.2	2.6	1.2	1.6	-0.5	0.9	-0.9
Lifetime Intake	2.4	2.7	5.0	-2.1	-2.2	1.1	-1.6	0.8
Incentive Sensitization - Responses	0.1	0.1	0.3	-0.4	-0.6	0.1	-0.4	0.4
Incentive Sensitization - Breakpoint	0.2	0.2	0.5	-0.4	-0.7	0.0	-0.3	0.6
Progressive ratio test 1 active lever presses	0.5	0.5	1.6	-0.3	-0.7	-0.4	-0.1	1.3
Progressive ratio test 1 breakpoint	0.4	0.5	1.7	-0.1	-0.6	-0.5	0.1	1.3
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.4	-0.5	-0.7	0.1	-0.5	0.5
Progressive ratio test 2 active lever presses	1.0	1.1	2.6	-0.8	-1.4	-0.1	-0.5	1.6
Progressive ratio test 2 breakpoint	1.2	1.3	4.5	-0.4	-1.2	-0.7	-0.0	2.1
Progressive ratio test 2 inactive lever presses	3.2	3.7	7.8	-1.8	-2.8	0.3	-1.3	2.3
Total sessions with >9 infusions	0.5	0.6	1.0	-0.9	-1.0	0.3	-0.8	0.5
Short access day 1 total inactive lever presses	0.9	1.0	2.1	-0.9	-1.5	0.1	-0.5	1.4
Short access day 10 total inactive lever presses	0.5	0.6	1.4	-0.7	-1.2	0.1	-0.3	0.9
Short access day 1 total infusions	1.7	1.8	3.2	-1.6	-1.8	0.9	-1.4	0.7
Short access day 10 total infusions	3.9	4.3	6.6	-2.6	-2.2	2.1	-2.4	-0.6
Short access total infusions	1.6	1.8	2.9	-1.7	-1.5	1.2	-1.6	-0.1
Short access day 1 locomotion	1.6	1.7	3.1	-1.6	-1.8	0.9	-1.4	0.5
Short access day 10 total locomotion	0.9	1.0	1.7	-1.3	-1.2	0.9	-1.1	0.1
Short access total locomotion	1.0	1.0	1.7	-1.3	-1.1	0.9	-1.2	0.0
Compulsive drug intake	2.5	2.5	5.7	1.8	2.4	-0.7	1.2	-1.3
One hour access (0.3 mA shock)	2.6	3.0	6.6	-1.4	-2.5	-0.1	-0.8	2.6
One hour access (shock baseline)	3.2	3.7	8.5	-1.5	-2.7	-0.2	-0.7	2.9
Number of responses in last shaping day	0.2	0.2	0.6	-0.0	-0.3	-0.4	-0.0	0.8
Context. condit. distance diff. score	0.5	0.6	1.4	-0.8	-1.2	0.3	-0.5	0.8
Locomotion velocity, session 1	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.1	-0.1
Locomotion distance, session 1	1.6	2.1	2.9	-1.5	-0.8	1.7	-1.6	-1.5
Locomotion velocity, session 2	0.7	0.9	2.3	0.6	1.3	0.1	0.2	-1.5
Locomotion distance, session 2	0.6	0.8	2.1	-0.6	0.2	1.0	-0.9	-1.4
Locomotion velocity, session 3	1.7	2.0	2.7	-1.6	-1.1	1.6	-1.6	-1.0
Locomotion distance, session 3	0.1	0.1	0.2	-0.4	-0.3	0.4	-0.5	-0.2
Stereotopy head waving bouts, day 3	1.5	1.8	2.8	-1.7	-1.4	1.4	-1.4	-0.4
Stereotopy head waving duration, day 3	1.0	1.2	2.1	-1.4	-1.5	0.9	-1.0	0.3
Locomotion velocity, session 7	1.2	1.3	1.7	-1.3	-1.0	1.3	-1.3	-0.7
Locomotion distance, session 7	0.1	0.2	0.5	-0.2	0.1	0.5	-0.4	-0.7
Stereotopy head waving bouts, day 7	1.4	1.6	2.6	-1.6	-1.4	1.3	-1.4	-0.2
Stereotopy head waving duration, day 7	1.7	2.0	3.0	-1.4	-0.6	1.7	-1.5	-1.6
Locomotion velocity, session 8	0.4	0.5	1.6	0.4	0.9	0.3	0.1	-1.3
Locomotion distance, session 8	0.4	0.6	0.9	-0.9	-0.9	0.6	-0.8	0.1
Degree of sensitization distance	0.3	0.3	0.6	-0.4	-0.1	0.6	-0.5	-0.7
Degree of sensitization stereotypy	0.7	0.7	1.1	-0.9	-0.4	1.1	-0.9	-0.9
Condit. Reinf. active minus inactive responses	0.5	0.5	0.7	-0.8	-0.4	0.8	-0.9	-0.6
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.5	-0.7	-0.6	0.6	-0.7	-0.2
Condit. Reinf. active responses	0.1	0.1	0.1	-0.3	-0.2	0.3	-0.4	-0.1
Condit. Reinf. inactive responses	0.1	0.1	0.1	0.3	-0.0	-0.3	0.1	0.3
Incentive salience index mean	0.3	0.4	0.6	-0.6	-0.3	0.7	-0.8	-0.6
Condit. Reinf. lever presses	0.0	0.0	0.1	0.3	0.2	-0.2	0.1	0.0
Time in familiar zone, hab. session 1	0.4	0.4	0.8	-0.7	-0.9	0.5	-0.7	0.3
Time in novel zone, hab. session 1	0.1	0.1	0.1	0.3	0.4	-0.2	0.3	-0.0
Total zone transitions, hab. session 1	0.2	0.3	0.8	-0.2	0.3	0.5	-0.4	-0.9
Total locomotion distance, hab. session 1	0.3	0.4	0.8	-0.6	-0.9	0.3	-0.6	0.6
Locomotion velocity, hab. session 1	0.1	0.1	0.2	-0.3	-0.4	0.1	-0.3	0.3
Time in familiar zone, hab. session 2	0.9	0.9	1.5	1.2	1.2	-0.8	1.1	-0.2
Time in novel zone, hab. session 2	1.4	1.4	2.0	-1.4	-1.1	1.2	-1.4	-0.5
Total zone transitions, hab. session 2	3.6	4.7	6.8	-2.1	-1.0	2.6	-2.3	-2.4
Total locomotion distance, hab. session 2	1.5	1.9	2.6	-1.6	-1.2	1.6	-1.6	-0.8
Locomotion velocity, hab. session 2	1.4	1.9	2.7	-1.6	-1.4	1.5	-1.6	-0.5
Novel to familiar place preference ratio	0.5	0.5	0.7	-0.8	-0.4	0.8	-0.7	-0.7
Novelty place preference	0.6	0.6	0.9	-0.9	-0.7	0.9	-0.8	-0.5
Time in novel zone, NPP test	0.6	0.6	0.9	-0.9	-0.7	0.9	-0.8	-0.5
Total zone transitions, NPP test	1.0	1.4	2.9	-0.9	-0.2	1.4	-1.2	-1.7
Total locomotion distance, NPP test	0.4	0.6	0.9	-0.9	-0.8	0.8	-0.9	-0.3
Locomotion velocity, NPP test	0.2	0.4	0.5	-0.7	-0.6	0.6	-0.7	-0.2
Pavlov. Cond. lever latency	0.1	0.1	0.3	0.3	-0.0	-0.4	0.4	0.6
Pavlov. Cond. magazine entry latency	1.3	1.6	2.2	-1.5	-1.3	1.4	-1.5	-0.6
Pavlov. Cond. change in total contacts	0.7	0.7	1.2	-1.0	-1.1	0.7	-0.9	0.2
Pavlov. Cond. index score	0.1	0.1	0.1	-0.3	-0.4	0.2	-0.3	0.1
Pavlov. Cond. latency score	0.1	0.2	0.3	-0.5	-0.5	0.4	-0.5	-0.1
Pavlov. Cond. lever contacts	0.1	0.1	0.2	-0.3	-0.2	0.3	-0.4	-0.2
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.0	0.2	0.1	-0.0	-0.3
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.0	0.8	0.4	-1.0	1.0	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	-0.2	-0.3	0.2	-0.3	0.0
Pavlov. Cond. response bias	0.0	0.1	0.1	-0.2	-0.3	0.1	-0.2	0.1
Bone: apparent density	2.8	4.6	6.6	-2.3	-1.4	2.6	-2.4	-1.9
Bone surface	2.7	4.7	8.5	-1.8	-0.5	2.6	-2.2	-2.9
Bone volume	2.1	3.6	5.2	-1.9	-1.1	2.3	-2.1	-1.9
Bone: connectivity density	3.2	5.0	8.4	-1.9	-0.6	2.7	-2.3	-2.9
Bone: cortical apparent density	0.3	0.4	0.8	0.7	0.9	-0.3	0.5	-0.6
Bone: cortical area	0.6	0.9	1.4	1.2	1.2	-0.8	1.0	-0.2
Bone: cortical porosity	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.4	-0.2
Bone: cortical porosity	0.1	0.1	0.3	0.1	0.3	0.2	-0.1	-0.5
Bone: cortical thickness	3.5	5.7	10.9	2.9	3.3	-1.7	2.3	-1.1
Bone: cortical thickness	1.3	1.5	3.0	1.5	1.7	-0.7	1.1	-0.9
Bone: cortical tissue density	0.4	0.5	1.1	0.8	1.0	-0.3	0.6	-0.6
Bone: elastic displacement	3.1	3.5	4.5	2.1	1.4	-2.1	2.1	1.4
Bone: elastic work	1.9	2.5	4.2	2.0	2.1	-1.3	1.6	-0.4
Bone: endosteal estimation	1.4	3.1	5.7	-2.1	-2.4	1.3	-1.8	0.7
Bone: endosteal perimeter	2.9	6.0	11.4	-2.9	-3.4	1.8	-2.4	1.0
Bone: final force	0.5	0.8	3.0	-0.0	0.7	0.7	-0.2	-1.7
Bone: final moment	0.4	0.7	2.6	0.1	0.7	0.6	-0.2	-1.6
Bone: marrow area	1.4	3.1	5.7	-2.1	-2.4	1.3	-1.7	0.7
Bone: maximum diameter	0.1	0.1	0.4	0.2	-0.1	-0.4	0.3	0.6
Bone: maximum force	1.7	3.0	5.9	-1.4	-0.4	2.1	-1.6	-2.4
Bone: maximum moment	1.4	2.5	5.0	-1.2	-0.3	1.9	-1.5	-2.2
Bone: minimum diameter	2.0	3.8	5.5	-2.3	-2.3	1.8	-2.1	-0.0
Bone: periosteal estimation	0.1	0.2	0.4	-0.5	-0.7	0.2	-0.4	0.3
Bone: periosteal perimeter	0.4	0.6	0.9	-0.9	-0.9	0.8	-0.8	-0.0
Bone: post-yield work	8.5	11.6	16.3	-4.0	-3.2	3.7	-3.8	-1.6
Bone: stiffness	2.0	3.2	4.6	-1.8	-0.7	2.1	-1.8	-2.1
Bone: tissue strength	0.3	0.3	0.4	-0.6	-0.6	0.4	-0.6	0.1
Bone: trabecular number	2.4	3.7	5.3	-2.0	-1.3	2.3	-2.1	-1.8
Bone: trabecular spacing	0.7	0.9	1.5	0.9	0.5	-1.2	1.1	1.0
Bone: trabecular thickness	1.9	2.3	3.2	-1.8	-1.7	1.5	-1.7	-0.3
Bone: trabecular tissue density	2.1	3.0	10.3	0.4	-1.1	-1.7	0.9	3.2
Breakpoint value in progressive ratio session	0.6	0.7	2.4	0.3	1.0	0.4	-0.1	-1.6
Distance traveled before self-admin	0.1	0.1	0.2	-0.1	-0.1	0.4	-0.3	-0.5
Distance traveled after self-admin	0.0	0.0	0.1	-0.1	-0.2	0.3	-0.2	-0.2
Delta time in closed arm before/after self-admin	0.7	0.7	1.6	0.9	1.3	-0.6	0.7	-0.5
Delta time in open arm before/after self-admin	0.2	0.2	0.2	-0.5	-0.4	0.2	-0.5	0.2
Diff in mean of infusions in LGA sessions	0.2	0.2	0.4	0.5	0.6	-0.2	0.5	-0.4
Extinction: sum of active levers before priming	1.4	1.4	5.0	-0.0	0.8	1.1	-0.5	-2.2
Active lever presses in extinction session 6	1.5	1.4	2.8	1.4	1.7	-1.1	1.1	-0.2
Delta distance traveled before/after self-admin	0.0	0.0	0.0	0.0	0.1	-0.1	0.1	0.1
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	0.2	0.4	-0.2	0.3	-0.0
Time in closed arm before self-admin	0.2	0.2	0.4	-0.6	-0.6	0.4	-0.5	0.2
Time in closed arm after self-admin	0.2	0.2	0.3	0.5	0.5	-0.4	0.4	0.1
Time in open arm before self-admin	0.2	0.3	0.5	0.6	0.7	-0.3	0.5	-0.4
Time in open arm after self-admin	0.0	0.0	0.1	0.3	0.2	-0.2	0.2	0.1
Sum of active levers in priming session hrs 5-6	3.2	3.1	4.1	2.0	1.7	-1.9	2.0	0.8
Time to tail flick, vehicle, before self-admin	2.1	2.2	3.4	-1.6	-0.9	1.8	-1.4	-1.5
Time to tail flick, vehicle, after self-admin	0.9	0.9	3.3	0.0	0.8	0.7	-0.5	-1.8
Time to tail flick, test, before self-admin	2.1	2.0	2.9	-1.7	-1.2	1.6	-1.7	-0.8
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.1	0.3	-0.1	0.4	-0.2
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.7	0.7	0.8	-0.2	0.1	-0.8
Delta time to tail flick, test, before/after SA	3.9	3.5	5.4	2.2	2.0	-1.8	2.3	0.4
Ambulatory time before self-admin	0.2	0.2	0.4	-0.4	-0.4	0.6	-0.5	-0.5
Ambulatory time after self-admin	1.1	1.3	2.0	-1.3	-1.4	1.1	-1.2	-0.1
Total heroin consumption	1.3	1.5	3.9	0.8	1.7	0.2	0.3	-2.0
Area under the delay curve	1.0	1.1	1.7	-1.3	-1.0	1.2	-1.1	-0.6
Delay disc. indifference point, 0s delay	1.8	1.9	2.7	-1.5	-1.3	1.7	-1.4	-0.9
Delay disc. indifference point, 16s delay	0.7	0.7	1.5	-0.9	-1.2	0.2	-0.4	0.9
Delay disc. indifference point, 2s delay	0.6	0.7	1.1	-1.1	-1.0	0.8	-0.9	0.0
Delay disc. indifference point, 24s delay	0.3	0.3	0.4	0.6	0.6	-0.5	0.7	0.1
Delay disc. indifference point, 4s delay	0.4	0.4	0.6	-0.7	-0.5	0.8	-0.8	-0.5
Delay disc. indifference point, 8s delay	0.4	0.4	0.6	-0.8	-0.4	0.7	-0.6	-0.6
Delay discount exponential model param	0.8	0.8	1.2	1.1	0.8	-1.0	1.0	0.5
Delay discount hyperbolic model param	0.8	0.8	1.2	1.1	0.8	-1.0	1.0	0.6
Fecal boli incidents, locomotor time 1	0.0	0.0	0.1	-0.2	-0.0	-0.0	-0.1	0.2
Change in fecal boli incidents, locomotor task	0.2	0.2	0.5	-0.3	0.1	0.5	-0.3	-0.7
Time >=10cm from walls, locomotor time 1	3.3	3.4	5.2	-2.2	-2.3	1.6	-2.0	0.0
Bouts of movement, locomotor time 1	0.9	1.0	1.6	1.3	1.3	-0.8	1.1	-0.3
Total resting periods, locomotor time 1	0.7	0.8	1.3	1.2	1.0	-0.8	0.9	-0.0
Rest time, locomotor task time 1	1.2	1.3	3.2	0.8	-0.0	-1.3	1.0	1.8
Distance moved, locomotor task time 1	1.2	1.3	1.7	-1.3	-0.9	1.3	-1.2	-0.9
Vertical activity count, locomotor time 1	0.8	0.9	1.9	-1.2	-1.4	0.6	-0.6	0.5
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.3	0.3	-0.1	-0.5	0.2	0.6
Bouts of movement, locomotor time 2	0.3	0.3	0.9	0.6	0.9	-0.2	0.3	-0.5
Total resting periods, locomotor time 2	0.1	0.1	0.3	0.3	0.5	0.0	0.0	-0.4
Rest time, locomotor task time 2	1.2	1.4	2.9	-1.3	-1.7	0.7	-0.9	0.9
Distance moved, locomotor task time 2	0.6	0.7	1.2	1.0	1.1	-0.7	0.9	-0.3
Vertical activity count, locomotor time 2	2.4	2.6	3.6	1.9	1.5	-1.8	1.8	0.8
Weight adjusted by age	0.4	0.5	1.3	0.4	1.0	0.1	0.1	-1.2
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	1.1	-1.0	-0.7	1.1	-0.8	-0.8
Locomotion in novel chamber	2.4	3.0	6.4	-1.5	-2.5	0.2	-1.0	2.3
Locomotion in novel chamber post-restriction	0.9	1.1	3.5	-0.4	-1.3	-0.3	-0.1	1.9
Progressive ratio	3.5	4.0	6.5	-1.7	-0.6	2.5	-2.0	-2.6
Food seeking constrained by brief footshock	0.1	0.1	0.5	-0.0	0.4	0.3	0.0	-0.7
Seeking ratio, punishment vs. effort	2.1	2.6	4.2	1.3	0.6	-2.0	1.7	2.0
Run reversals in cocaine runway, females	1.8	1.8	3.1	-1.1	-0.3	1.6	-1.5	-1.7
Run reversals in cocaine runway, males	1.0	1.0	1.4	1.2	1.1	-1.0	1.1	0.3
Latency to leave start box in cocaine runway	1.3	1.4	1.9	-1.4	-1.2	1.3	-1.3	-0.5
Latency to leave start box in cocaine runway, F	0.8	0.9	1.2	-1.1	-0.9	1.1	-1.1	-0.6
Latency to leave start box in cocaine runway, M	0.1	0.0	0.1	-0.3	-0.3	0.2	-0.2	0.0
Cd content in liver	0.6	0.6	2.2	0.1	-0.7	-0.6	0.3	1.5
Co content in liver	1.0	1.2	1.7	1.1	0.6	-1.3	1.1	1.1
Cu content in liver	0.1	0.1	0.3	0.4	0.5	-0.3	0.3	-0.2
Fe content in liver	0.0	0.0	0.0	0.2	0.1	0.0	-0.1	-0.2
K content in liver	1.7	1.7	3.1	-1.1	-0.2	1.5	-1.3	-1.8
Mg content in liver	3.4	3.6	4.7	-2.2	-1.6	2.1	-2.2	-1.2
Mn content in liver	0.4	0.5	1.6	0.2	0.8	0.4	-0.2	-1.3
Na content in liver	0.3	0.4	0.5	0.7	0.6	-0.6	0.7	0.2
Rb content in liver	2.6	3.3	4.9	-2.2	-2.2	1.7	-2.0	0.0
Se content in liver	0.9	1.0	1.8	-1.3	-1.1	1.0	-1.1	-0.2
Sr content in liver	1.7	1.6	3.1	1.4	1.8	-0.8	1.2	-0.7
Zn content in liver	0.3	0.4	0.7	0.5	0.9	-0.0	0.3	-0.8