Hub : Genes

Pde6c

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000016593 0.11 0.04 0.0e+00 0.14 0.15 0.14 0.14 7.0e-15 1.0e-16 1.1e-15 1.3e-15
2 Liver gene expression ENSRNOG00000016593 0.08 0.06 6.4e-05 0.03 0.02 0.02 0.02 6.1e-04 2.2e-03 1.9e-03 1.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
BMI with tail0.41.41.90.9-1.4
BMI without tail1.22.62.91.5-1.7
Body weight0.31.31.71.3-1.0
Epididymis fat weight0.30.81.00.8-1.0
Glucose0.10.20.40.60.0
Heart weight0.40.61.2-0.21.1
Left kidney weight0.20.50.9-0.10.9
Right kidney weight1.02.94.6-1.12.1
Tail length0.31.01.81.3-0.4
Length with tail0.10.20.30.50.5
Length without tail0.10.30.6-0.20.8
Liver weight, left0.10.20.50.70.1
Liver weight, right0.00.10.10.30.3
Parametrial fat weight0.10.20.3-0.10.6
Retroperitoneal fat weight0.00.00.00.00.1
Intraocular pressure0.20.30.3-0.50.6
Extensor digitorum longus weight0.20.80.91.0-0.8
Soleus weight1.43.94.72.2-1.8
Tibialis anterior weight0.72.32.41.5-1.5
Tibia length0.10.20.4-0.20.6
Number of licking bursts1.31.62.3-1.50.9
Food consumed during 24 hour testing period0.10.10.20.00.4
Times rat made contact with spout0.60.71.10.4-1.1
Mean time between licks in bursts0.10.20.2-0.40.4
Mean num. licks in bursts2.93.43.92.0-1.7
Std. dev. time between licks in bursts2.73.23.4-1.91.7
Water consumed over 24 hours1.41.72.31.0-1.5
Indifference point 0 sec0.60.91.2-0.81.1
Indifference point AUC3.94.55.6-1.92.4
Indifference point function ln k4.66.57.32.4-2.7
Indifference point function log k4.66.57.32.4-2.7
Delay discounting total patch changes 0 sec0.40.70.9-0.71.0
Delay discounting total patch changes 12 sec4.25.55.6-2.42.3
Delay discounting total patch changes 18 sec0.81.01.2-1.10.9
Delay discounting total patch changes 24 sec0.40.50.9-0.40.9
Delay discounting total patch changes 6 sec3.35.16.4-1.92.5
Delay discounting time to switch 0 sec1.21.82.5-1.61.0
Delay discounting water rate 0 sec1.62.53.01.7-1.4
Delay discounting water rate 12 sec0.81.21.61.3-0.9
Delay discounting water rate 18 sec2.12.83.41.8-1.5
Delay discounting water rate 24 sec0.91.31.41.2-1.1
Delay discounting water rate 6 sec0.10.20.30.5-0.4
Locomotor activity0.30.40.80.3-0.9
Locomotor testing distance0.40.61.10.4-1.0
Locomotor testing rearing1.21.92.51.1-1.6
Light reinforcement 10.10.20.4-0.60.3
Light reinforcement 21.11.42.2-1.50.8
Reaction time number correct2.33.34.41.5-2.1
Reaction time mean minus median0.40.50.80.9-0.4
Reaction time mean minus median AUC0.10.10.20.4-0.3
Reaction time num false alarms0.20.20.4-0.10.7
Reaction time num false alarms AUC0.20.20.5-0.10.7
Reaction time trials correct on left2.33.34.41.5-2.1
Reaction time trials on left2.33.24.21.5-2.0
Reaction time mean0.50.71.1-0.51.0
Reaction time mean AUC0.91.21.7-0.81.3
Median of all reaction times0.81.01.4-0.81.2
Reaction time omissions0.71.01.41.2-0.8
Reaction time false alarm rate1.11.62.6-0.81.6
Reaction time premature initiation rate0.50.61.1-0.31.1
Reaction time premature initiations0.10.10.30.5-0.1
Std. dev. reaction times0.10.10.10.30.4
Reaction time trials completed2.33.24.21.5-2.0
Reaction time trials AUC2.02.83.81.4-2.0
Social response proportion2.62.83.31.5-1.8
Social responses0.50.60.90.9-0.6
Social time0.70.91.1-0.81.0
Conditioned locomotion0.00.00.10.1-0.2
Cocaine response after cond. corrected0.20.20.3-0.20.6
Cocaine response after cond. not corrected0.10.10.1-0.00.4
Cocaine response before conditioning0.00.00.00.1-0.2
Saline control response2.53.44.2-2.01.6
Condit. Reinf. active minus inactive responses2.32.93.11.7-1.8
Condit. Reinf. active-inactive response ratio1.11.11.50.9-1.2
Condit. Reinf. active responses0.40.60.80.9-0.6
Condit. Reinf. inactive responses0.60.81.4-0.51.2
Condit. Reinf. lever presses0.20.30.4-0.50.7
Condit. Reinf. lever reinforcers received0.10.20.30.5-0.4
Pavlov. Cond. lever latency1.41.92.71.1-1.6
Pavlov. Cond. magazine entry latency0.00.00.10.30.1
Pavlov. Cond. change in total contacts0.40.60.9-0.50.9
Pavlov. Cond. index score0.50.61.0-0.41.0
Pavlov. Cond. latency score0.30.40.7-0.20.8
Pavlov. Cond. lever contacts1.11.52.2-1.01.5
Pavlov. Cond. magazine entry number1.31.62.31.0-1.5
Pavlov. Cond. intertrial magazine entries0.91.11.50.8-1.2
Pavlov. Cond. lever-magazine prob. diff.0.30.40.7-0.30.9
Pavlov. Cond. response bias0.91.32.0-0.81.4
Conditioned reinforcement - actives1.00.91.11.1-0.9
Conditioned reinforcement - inactives3.94.44.72.2-2.0
Conditioned locomotion0.20.20.40.6-0.1
Intermittent access intake day 1-15 change5.15.15.12.3-2.2
Intermittent access intake escalation4.04.04.12.0-2.0
Intermittent access intake escalation 25.85.86.42.3-2.5
Intermitt. access day 1 inactive lever presses0.20.20.20.5-0.5
Intermitt. access day 15 inactive lever presses0.70.81.01.0-0.7
Intermitt. access escalation Index1.71.52.11.0-1.5
Intermittent access day 1 total infusions0.80.91.21.1-0.8
Intermittent access day 15 total infusions4.04.55.52.3-1.9
Intermittent access terminal intake (last 3 days)3.94.34.62.1-2.0
Intermittent access total infusions2.32.52.81.7-1.5
Intermittent access day 1 locomotion0.20.20.40.60.0
Intermittent access day 15 total locomotion0.10.10.2-0.00.5
Intermittent access total locomotion0.00.00.00.10.1
Intermittent access standard deviation5.15.46.42.5-2.1
Cocaine induced anxiety0.40.50.90.3-0.9
Post-drug Anxiety1.01.11.7-1.30.6
Baseline Anxiety1.41.41.8-1.01.3
Lifetime Intake1.11.21.41.2-1.0
Incentive Sensitization - Responses6.26.26.42.4-2.5
Incentive Sensitization - Breakpoint5.55.55.72.3-2.4
Progressive ratio test 1 active lever presses0.80.90.90.9-0.9
Progressive ratio test 1 breakpoint0.91.01.01.0-1.0
Progressive ratio test 1 inactive lever presses3.94.24.32.1-2.0
Progressive ratio test 2 active lever presses3.53.83.91.9-2.0
Progressive ratio test 2 breakpoint4.55.05.22.2-2.3
Progressive ratio test 2 inactive lever presses2.63.03.51.5-1.9
Total sessions with >9 infusions0.10.10.1-0.10.3
Short access day 1 total inactive lever presses2.12.33.31.1-1.8
Short access day 10 total inactive lever presses0.10.10.2-0.2-0.5
Short access day 1 total infusions0.30.30.4-0.60.5
Short access day 10 total infusions0.10.10.2-0.10.5
Short access total infusions0.10.10.10.3-0.2
Short access day 1 locomotion0.00.00.0-0.1-0.1
Short access day 10 total locomotion0.00.00.1-0.00.2
Short access total locomotion0.10.10.2-0.40.3
Compulsive drug intake3.93.94.02.0-2.0
One hour access (0.3 mA shock)8.29.610.13.2-3.0
One hour access (shock baseline)1.21.31.61.3-1.0
Number of responses in last shaping day0.10.10.20.1-0.5
Context. condit. distance diff. score1.41.71.81.3-1.3
Locomotion velocity, session 11.81.92.2-1.51.3
Locomotion distance, session 10.91.11.2-1.11.0
Locomotion velocity, session 20.60.70.70.7-0.9
Locomotion distance, session 20.00.00.0-0.20.1
Locomotion velocity, session 30.40.40.50.6-0.7
Locomotion distance, session 30.50.50.80.9-0.5
Stereotopy head waving bouts, day 30.10.20.30.2-0.6
Stereotopy head waving duration, day 30.20.20.30.3-0.6
Locomotion velocity, session 73.53.84.22.0-1.8
Locomotion distance, session 72.33.03.81.9-1.5
Stereotopy head waving bouts, day 70.10.10.2-0.1-0.4
Stereotopy head waving duration, day 70.10.10.30.1-0.5
Locomotion velocity, session 80.30.40.40.6-0.6
Locomotion distance, session 80.50.81.00.7-1.0
Degree of sensitization distance0.20.20.20.4-0.4
Degree of sensitization stereotypy0.10.10.2-0.40.1
Condit. Reinf. active minus inactive responses0.00.00.0-0.10.2
Condit. Reinf. active-inactive response ratio0.00.00.1-0.20.2
Condit. Reinf. active responses0.00.00.00.00.2
Condit. Reinf. inactive responses0.00.00.1-0.10.3
Incentive salience index mean0.60.70.9-0.80.9
Condit. Reinf. lever presses2.63.43.6-1.81.9
Time in familiar zone, hab. session 10.10.10.10.2-0.4
Time in novel zone, hab. session 10.20.20.2-0.30.5
Total zone transitions, hab. session 10.00.00.0-0.20.0
Total locomotion distance, hab. session 11.21.72.1-1.41.1
Locomotion velocity, hab. session 12.33.33.8-2.01.7
Time in familiar zone, hab. session 20.10.10.1-0.30.3
Time in novel zone, hab. session 20.00.00.00.10.1
Total zone transitions, hab. session 21.01.31.4-1.11.2
Total locomotion distance, hab. session 21.31.81.8-1.31.4
Locomotion velocity, hab. session 21.52.12.2-1.51.4
Novel to familiar place preference ratio4.14.35.01.9-2.2
Novelty place preference4.44.65.32.0-2.3
Time in novel zone, NPP test4.54.85.52.0-2.3
Total zone transitions, NPP test1.21.82.2-1.21.5
Total locomotion distance, NPP test2.53.43.5-1.81.9
Locomotion velocity, NPP test2.33.33.5-1.81.9
Pavlov. Cond. lever latency0.00.00.0-0.10.1
Pavlov. Cond. magazine entry latency0.60.71.1-0.61.1
Pavlov. Cond. change in total contacts0.00.00.00.20.2
Pavlov. Cond. index score0.20.30.5-0.40.7
Pavlov. Cond. latency score0.20.20.3-0.40.6
Pavlov. Cond. lever contacts0.50.60.7-0.60.8
Pavlov. Cond. magazine entry number0.10.10.2-0.1-0.4
Pavlov. Cond. intertrial magazine entries0.00.00.0-0.10.1
Pavlov. Cond. lever-magazine prob. diff.0.30.40.5-0.50.7
Pavlov. Cond. response bias0.20.30.5-0.20.7
Bone: apparent density4.57.58.02.6-2.8
Bone surface3.86.77.32.7-2.5
Bone volume3.96.66.92.6-2.5
Bone: connectivity density6.39.810.63.0-3.3
Bone: cortical apparent density0.91.11.5-1.20.9
Bone: cortical area1.01.52.41.5-0.7
Bone: cortical porosity0.70.81.10.7-1.0
Bone: cortical porosity1.51.61.61.2-1.3
Bone: cortical thickness1.11.82.4-1.11.6
Bone: cortical thickness2.22.52.6-1.61.6
Bone: cortical tissue density0.81.11.4-1.20.8
Bone: elastic displacement0.20.20.2-0.4-0.5
Bone: elastic work0.70.91.60.5-1.2
Bone: endosteal estimation6.614.217.54.2-3.3
Bone: endosteal perimeter6.112.514.43.8-3.2
Bone: final force0.20.30.50.70.1
Bone: final moment0.20.30.60.80.1
Bone: marrow area6.714.517.74.2-3.4
Bone: maximum diameter7.112.914.33.8-3.4
Bone: maximum force1.01.72.61.6-0.9
Bone: maximum moment0.91.72.61.6-0.8
Bone: minimum diameter8.716.020.14.5-3.4
Bone: periosteal estimation4.38.711.43.4-2.5
Bone: periosteal perimeter4.37.28.52.9-2.4
Bone: post-yield work1.41.92.81.7-0.9
Bone: stiffness1.32.02.91.7-1.0
Bone: tissue strength0.10.10.20.4-0.1
Bone: trabecular number4.26.56.62.6-2.5
Bone: trabecular spacing2.02.52.9-1.51.7
Bone: trabecular thickness3.23.93.92.0-2.0
Bone: trabecular tissue density0.60.91.00.9-1.0
Breakpoint value in progressive ratio session0.20.20.2-0.30.5
Distance traveled before self-admin1.21.31.61.0-1.3
Distance traveled after self-admin3.84.25.11.8-2.3
Delta time in closed arm before/after self-admin0.50.50.9-0.21.0
Delta time in open arm before/after self-admin1.51.42.10.8-1.4
Diff in mean of infusions in LGA sessions2.52.83.11.8-1.6
Extinction: sum of active levers before priming0.10.10.20.50.2
Active lever presses in extinction session 63.33.23.71.6-1.9
Delta distance traveled before/after self-admin1.61.71.81.2-1.3
Delta ambulatory time before/after self-admin2.73.03.01.7-1.7
Time in closed arm before self-admin1.92.23.11.1-1.8
Time in closed arm after self-admin0.10.10.1-0.40.2
Time in open arm before self-admin0.30.30.4-0.60.5
Time in open arm after self-admin0.10.10.20.2-0.5
Sum of active levers in priming session hrs 5-60.00.00.00.1-0.1
Time to tail flick, vehicle, before self-admin0.50.50.9-1.00.2
Time to tail flick, vehicle, after self-admin0.60.60.70.9-0.7
Time to tail flick, test, before self-admin3.13.03.71.9-1.5
Time to tail flick, test, after self-admin1.61.62.31.0-1.5
Delta time to tail flick, vehicle, before/after SA2.12.02.71.7-1.1
Delta time to tail flick, test, before/after SA0.10.10.1-0.1-0.4
Ambulatory time before self-admin0.70.71.10.6-1.1
Ambulatory time after self-admin6.67.38.72.4-3.0
Total heroin consumption0.10.10.2-0.00.4
Area under the delay curve0.30.30.5-0.70.3
Delay disc. indifference point, 0s delay1.82.03.20.9-1.8
Delay disc. indifference point, 16s delay0.20.20.2-0.50.5
Delay disc. indifference point, 2s delay0.10.10.1-0.3-0.2
Delay disc. indifference point, 24s delay1.11.11.5-0.81.2
Delay disc. indifference point, 4s delay0.20.30.5-0.70.2
Delay disc. indifference point, 8s delay2.32.43.2-1.81.3
Delay discount exponential model param0.40.40.60.8-0.4
Delay discount hyperbolic model param0.30.30.50.7-0.3
Fecal boli incidents, locomotor time 10.80.91.01.0-0.9
Change in fecal boli incidents, locomotor task1.00.91.1-1.00.9
Time >=10cm from walls, locomotor time 10.60.61.21.1-0.1
Bouts of movement, locomotor time 10.00.00.1-0.2-0.1
Total resting periods, locomotor time 10.00.10.1-0.30.1
Rest time, locomotor task time 10.50.50.90.3-1.0
Distance moved, locomotor task time 10.50.51.0-0.21.0
Vertical activity count, locomotor time 10.50.51.0-0.31.0
Time >=10cm from walls, locomotor time 20.70.70.70.8-0.9
Bouts of movement, locomotor time 21.71.82.7-1.71.0
Total resting periods, locomotor time 21.51.62.5-1.60.9
Rest time, locomotor task time 20.40.50.7-0.80.5
Distance moved, locomotor task time 20.70.91.31.1-0.7
Vertical activity count, locomotor time 20.50.60.80.9-0.5
Weight adjusted by age0.10.10.2-0.4-0.3
Seeking ratio, delayed vs. immediate footshock0.10.10.1-0.20.3
Locomotion in novel chamber3.44.25.41.7-2.3
Locomotion in novel chamber post-restriction0.20.20.4-0.10.6
Progressive ratio0.10.10.2-0.40.1
Food seeking constrained by brief footshock0.20.20.40.6-0.0
Seeking ratio, punishment vs. effort0.20.20.40.60.1
Run reversals in cocaine runway, females0.10.10.1-0.30.3
Run reversals in cocaine runway, males3.53.44.1-1.62.0
Latency to leave start box in cocaine runway2.32.52.91.4-1.7
Latency to leave start box in cocaine runway, F3.84.25.01.8-2.2
Latency to leave start box in cocaine runway, M0.00.00.00.2-0.1
Cd content in liver1.51.72.2-1.11.5
Co content in liver0.40.50.6-0.80.6
Cu content in liver4.95.96.4-2.52.3
Fe content in liver2.53.03.9-2.01.5
K content in liver0.20.20.4-0.60.1
Mg content in liver1.01.01.4-1.20.8
Mn content in liver3.13.54.4-2.11.6
Na content in liver2.12.33.0-1.71.2
Rb content in liver0.20.20.30.5-0.4
Se content in liver21.425.929.1-5.44.8
Sr content in liver0.00.00.10.3-0.0
Zn content in liver2.12.32.7-1.61.3