Hub : Genes

Gpr45

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	ENSRNOG00000016446	0.2	0.11	1.8e-08	0.08	0.12	0.1	0.11	4.2e-05	4.5e-07	6.2e-06	1.4e-06
2	Brain	gene expression	ENSRNOG00000016446	0.05	0.04	1.6e-04	0.04	0.04	0.03	0.04	6.7e-05	2.5e-04	5.2e-04	2.8e-04
3	Brain	intron excision ratio	chr9:45222208:45222446	0.07	0.05	1.5e-04	0.02	0.04	0.05	0.05	6.2e-03	1.7e-04	2.8e-05	1.3e-05
4	NAcc	gene expression	ENSRNOG00000016446	0.1	0.08	2.1e-05	0.08	0.07	0.05	0.07	1.4e-06	6.7e-06	2.3e-04	2.9e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
BMI with tail	1.5	4.9	6.6	2.6	-2.5	1.1	-2.4
BMI without tail	0.0	0.1	0.2	-0.3	0.2	0.4	0.2
Body weight	0.0	0.0	0.1	0.3	-0.0	0.1	-0.1
Epididymis fat weight	0.0	0.1	0.1	0.3	-0.4	0.3	-0.3
Glucose	0.2	0.3	0.5	-0.7	0.4	0.5	0.4
Heart weight	0.8	1.2	1.7	0.8	-1.0	1.1	-1.3
Left kidney weight	0.0	0.1	0.2	0.3	0.0	-0.1	-0.4
Right kidney weight	0.4	1.1	2.9	0.2	1.0	-1.7	0.6
Tail length	0.9	2.6	4.4	-2.1	1.8	0.2	1.7
Length with tail	0.4	1.3	2.1	-1.2	1.4	-0.5	1.2
Length without tail	0.5	1.1	2.3	1.5	-0.8	-0.7	-1.0
Liver weight, left	0.2	0.3	0.4	-0.4	0.6	-0.5	0.5
Liver weight, right	0.2	0.3	0.7	-0.6	0.5	-0.1	0.9
Parametrial fat weight	0.0	0.0	0.0	-0.1	0.1	0.0	0.2
Retroperitoneal fat weight	0.1	0.4	0.9	1.0	-0.3	-0.5	-0.4
Intraocular pressure	1.4	2.0	2.5	1.5	-1.6	1.0	-1.5
Extensor digitorum longus weight	6.3	25.3	37.6	6.1	-5.5	1.6	-5.5
Soleus weight	1.2	3.4	5.6	2.4	-2.0	0.2	-2.0
Tibialis anterior weight	3.0	10.4	16.0	4.0	-3.5	0.7	-3.6
Tibia length	0.4	1.3	1.7	-1.0	1.3	-1.1	1.1
Number of licking bursts	0.2	0.2	0.5	-0.5	0.0	0.7	-0.1
Food consumed during 24 hour testing period	0.4	0.5	0.6	0.6	-0.8	0.7	-0.7
Times rat made contact with spout	0.9	1.0	2.2	-1.2	0.5	1.5	0.4
Mean time between licks in bursts	1.1	1.6	2.8	1.7	-1.4	-0.0	-1.2
Mean num. licks in bursts	0.0	0.1	0.1	0.2	-0.2	0.4	-0.1
Std. dev. time between licks in bursts	0.7	0.9	1.2	0.8	-1.1	0.9	-1.0
Water consumed over 24 hours	0.1	0.1	0.3	0.0	-0.3	0.5	-0.2
Indifference point 0 sec	0.4	0.6	1.2	1.0	-0.3	-1.1	-0.4
Indifference point AUC	0.6	0.7	0.9	0.6	-0.8	1.0	-0.8
Indifference point function ln k	0.9	1.2	1.8	1.2	-1.2	0.3	-1.4
Indifference point function log k	0.9	1.2	1.8	1.2	-1.2	0.3	-1.4
Delay discounting total patch changes 0 sec	0.3	0.5	1.1	1.0	-0.5	-0.6	-0.6
Delay discounting total patch changes 12 sec	0.5	0.6	1.7	0.0	0.7	-1.3	0.6
Delay discounting total patch changes 18 sec	0.7	0.9	1.1	1.0	-1.0	0.7	-1.0
Delay discounting total patch changes 24 sec	0.3	0.4	0.9	0.7	-0.1	-1.0	0.1
Delay discounting total patch changes 6 sec	0.1	0.1	0.3	0.6	-0.0	-0.5	-0.0
Delay discounting time to switch 0 sec	0.7	1.1	1.3	-0.9	1.1	-1.1	1.1
Delay discounting water rate 0 sec	0.6	0.9	1.9	0.5	-0.9	1.4	-0.9
Delay discounting water rate 12 sec	0.4	0.5	0.6	0.5	-0.8	0.8	-0.8
Delay discounting water rate 18 sec	0.0	0.0	0.0	-0.0	-0.0	0.0	-0.1
Delay discounting water rate 24 sec	0.2	0.3	0.4	0.5	-0.6	0.3	-0.6
Delay discounting water rate 6 sec	0.8	1.2	1.8	0.7	-1.1	1.3	-1.1
Locomotor activity	0.1	0.2	0.3	-0.5	0.4	0.2	0.4
Locomotor testing distance	1.0	1.6	2.4	-1.4	1.4	-0.6	1.5
Locomotor testing rearing	1.5	2.3	2.8	-1.4	1.5	-1.5	1.7
Light reinforcement 1	1.9	3.4	6.4	2.5	-1.8	0.3	-2.0
Light reinforcement 2	0.4	0.5	0.9	1.0	-0.4	0.4	-0.8
Reaction time number correct	0.9	1.3	2.2	1.5	-1.3	0.0	-1.2
Reaction time mean minus median	0.7	0.9	1.8	-1.3	0.9	-0.1	1.0
Reaction time mean minus median AUC	0.5	0.7	1.3	-1.1	0.8	-0.1	0.9
Reaction time num false alarms	1.5	2.0	3.1	1.7	-1.6	0.5	-1.5
Reaction time num false alarms AUC	2.0	2.7	4.4	2.1	-1.8	0.5	-1.7
Reaction time trials correct on left	0.9	1.3	2.2	1.5	-1.3	0.0	-1.2
Reaction time trials on left	0.9	1.3	2.1	1.4	-1.2	0.0	-1.2
Reaction time mean	1.8	2.5	4.2	-2.1	1.7	-0.0	1.7
Reaction time mean AUC	1.3	1.8	3.1	-1.8	1.4	0.2	1.4
Median of all reaction times	1.7	2.3	3.8	-2.0	1.6	0.1	1.6
Reaction time omissions	0.7	0.9	1.4	-1.2	1.0	-0.3	1.1
Reaction time false alarm rate	0.5	0.8	1.3	1.1	-0.9	0.2	-0.9
Reaction time premature initiation rate	0.1	0.2	0.2	-0.3	0.3	-0.4	0.5
Reaction time premature initiations	0.1	0.1	0.1	0.4	-0.3	-0.3	-0.2
Std. dev. reaction times	1.2	1.6	2.7	-1.6	1.3	-0.3	1.4
Reaction time trials completed	0.9	1.3	2.1	1.4	-1.2	0.0	-1.2
Reaction time trials AUC	0.8	1.2	2.0	1.4	-1.2	0.0	-1.1
Social response proportion	0.3	0.3	0.6	-0.8	0.5	-0.2	0.6
Social responses	1.0	1.3	2.2	-1.5	1.2	-0.0	1.2
Social time	4.4	5.8	8.1	-2.9	2.7	-0.9	2.6
Conditioned locomotion	0.9	1.1	1.9	-1.4	1.1	0.0	1.1
Cocaine response after cond. corrected	1.1	1.2	3.4	0.2	-0.9	1.8	-0.8
Cocaine response after cond. not corrected	0.6	0.7	1.9	0.3	-0.7	1.4	-0.6
Cocaine response before conditioning	0.4	0.4	1.5	0.4	0.3	-1.2	0.2
Saline control response	0.3	0.4	1.3	0.6	0.0	-1.1	-0.1
Condit. Reinf. active minus inactive responses	0.2	0.3	0.7	-0.8	0.3	0.4	0.4
Condit. Reinf. active-inactive response ratio	1.2	1.2	2.3	-1.5	1.1	0.0	1.2
Condit. Reinf. active responses	0.2	0.2	0.5	-0.0	-0.5	0.7	-0.4
Condit. Reinf. inactive responses	1.0	1.2	1.8	1.3	-1.2	0.1	-1.3
Condit. Reinf. lever presses	0.1	0.1	0.2	-0.5	0.2	-0.2	0.3
Condit. Reinf. lever reinforcers received	0.3	0.4	0.8	0.2	-0.7	0.9	-0.6
Pavlov. Cond. lever latency	0.2	0.3	0.5	0.4	-0.5	0.7	-0.6
Pavlov. Cond. magazine entry latency	1.0	1.2	3.7	0.1	0.6	-1.9	0.7
Pavlov. Cond. change in total contacts	0.2	0.3	0.5	-0.7	0.6	-0.3	0.6
Pavlov. Cond. index score	0.5	0.6	1.2	-0.4	0.6	-1.1	0.8
Pavlov. Cond. latency score	0.3	0.4	1.0	-0.2	0.4	-1.0	0.6
Pavlov. Cond. lever contacts	0.5	0.8	0.9	-0.8	0.8	-1.0	0.9
Pavlov. Cond. magazine entry number	0.9	1.1	2.6	0.4	-0.9	1.6	-1.0
Pavlov. Cond. intertrial magazine entries	2.9	3.8	4.9	1.9	-2.1	1.5	-2.2
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.2	-0.2	0.5	-1.1	0.6
Pavlov. Cond. response bias	1.2	1.6	3.5	-0.6	1.1	-1.9	1.2
Conditioned reinforcement - actives	0.2	0.2	0.8	-0.1	-0.1	0.9	-0.1
Conditioned reinforcement - inactives	0.2	0.2	0.5	-0.4	0.4	-0.4	0.7
Conditioned locomotion	0.2	0.2	0.7	0.8	-0.5	-0.0	-0.2
Intermittent access intake day 1-15 change	0.1	0.1	0.2	-0.0	0.1	-0.4	0.2
Intermittent access intake escalation	0.3	0.3	0.3	-0.5	0.6	-0.5	0.5
Intermittent access intake escalation 2	0.3	0.3	0.5	-0.7	0.6	-0.2	0.6
Intermitt. access day 1 inactive lever presses	1.0	1.1	1.7	-0.8	1.0	-0.9	1.3
Intermitt. access day 15 inactive lever presses	0.4	0.4	1.4	0.0	0.2	-1.2	0.6
Intermitt. access escalation Index	0.0	0.0	0.0	0.0	0.0	-0.1	0.1
Intermittent access day 1 total infusions	0.8	0.9	3.0	-0.7	0.1	1.7	0.2
Intermittent access day 15 total infusions	0.5	0.5	0.8	-0.9	0.4	0.9	0.6
Intermittent access terminal intake (last 3 days)	0.4	0.5	1.4	-0.6	0.1	1.2	0.4
Intermittent access total infusions	0.7	0.7	2.2	-0.8	0.1	1.5	0.3
Intermittent access day 1 locomotion	0.0	0.0	0.1	-0.2	0.1	0.3	0.2
Intermittent access day 15 total locomotion	0.0	0.1	0.1	0.2	-0.3	0.2	-0.1
Intermittent access total locomotion	0.1	0.1	0.1	0.2	-0.3	0.3	-0.2
Intermittent access standard deviation	1.8	1.9	3.1	-1.8	1.5	0.5	1.4
Cocaine induced anxiety	1.9	2.2	4.0	2.0	-1.5	-0.8	-1.4
Post-drug Anxiety	1.0	1.2	1.7	1.3	-1.2	0.3	-1.2
Baseline Anxiety	1.1	1.2	2.3	-1.3	0.5	1.5	0.6
Lifetime Intake	0.5	0.6	2.1	-0.5	-0.0	1.4	0.0
Incentive Sensitization - Responses	0.3	0.3	1.1	0.0	0.2	-1.1	0.2
Incentive Sensitization - Breakpoint	0.4	0.4	1.4	0.2	0.1	-1.2	0.1
Progressive ratio test 1 active lever presses	0.7	0.7	1.0	0.6	-0.8	1.0	-0.9
Progressive ratio test 1 breakpoint	0.6	0.6	1.1	0.5	-0.7	1.0	-0.8
Progressive ratio test 1 inactive lever presses	0.9	1.0	1.6	-0.5	0.9	-1.1	1.3
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	0.0	-0.0	-0.0	-0.2
Progressive ratio test 2 breakpoint	0.1	0.2	0.2	0.4	-0.5	0.2	-0.5
Progressive ratio test 2 inactive lever presses	0.6	0.7	1.3	-0.4	0.7	-1.1	0.9
Total sessions with >9 infusions	1.2	1.3	1.5	1.1	-1.2	1.1	-1.2
Short access day 1 total inactive lever presses	0.5	0.6	1.7	0.2	0.4	-1.3	0.5
Short access day 10 total inactive lever presses	1.3	1.4	2.4	-0.6	1.1	-1.6	1.3
Short access day 1 total infusions	0.1	0.1	0.3	0.5	-0.3	0.0	-0.1
Short access day 10 total infusions	1.7	1.9	7.0	-0.5	-0.4	2.6	-0.5
Short access total infusions	0.5	0.5	1.7	0.2	-0.4	1.3	-0.5
Short access day 1 locomotion	0.2	0.2	0.3	0.5	-0.5	0.4	-0.4
Short access day 10 total locomotion	0.1	0.1	0.3	-0.5	0.5	0.2	0.2
Short access total locomotion	0.3	0.3	0.5	0.7	-0.4	0.1	-0.6
Compulsive drug intake	0.1	0.1	0.1	-0.3	0.3	-0.2	0.1
One hour access (0.3 mA shock)	1.9	2.2	4.3	-1.8	0.9	2.1	0.8
One hour access (shock baseline)	1.2	1.4	3.1	-1.3	0.6	1.8	0.7
Number of responses in last shaping day	0.6	0.7	1.0	-0.5	0.7	-0.9	1.0
Context. condit. distance diff. score	1.4	1.7	2.0	-1.2	1.4	-1.2	1.4
Locomotion velocity, session 1	0.0	0.0	0.1	-0.1	-0.0	0.3	-0.0
Locomotion distance, session 1	0.7	1.0	1.9	1.4	-1.0	-0.3	-0.9
Locomotion velocity, session 2	3.0	3.5	5.1	2.2	-2.1	0.7	-2.1
Locomotion distance, session 2	2.2	3.1	4.1	2.0	-2.0	0.9	-1.9
Locomotion velocity, session 3	0.2	0.2	0.5	-0.2	0.4	-0.7	0.5
Locomotion distance, session 3	0.1	0.2	0.3	-0.3	0.3	-0.4	0.6
Stereotopy head waving bouts, day 3	0.2	0.2	0.5	-0.7	0.5	-0.0	0.5
Stereotopy head waving duration, day 3	0.1	0.1	0.2	-0.4	0.1	0.3	0.1
Locomotion velocity, session 7	1.2	1.4	2.7	1.6	-1.0	-0.8	-1.0
Locomotion distance, session 7	0.8	1.1	1.5	1.2	-1.2	0.3	-1.1
Stereotopy head waving bouts, day 7	0.1	0.1	0.1	-0.4	0.3	-0.1	0.4
Stereotopy head waving duration, day 7	0.4	0.5	0.9	-0.3	0.6	-1.0	0.7
Locomotion velocity, session 8	0.5	0.6	2.2	0.3	0.3	-1.5	0.4
Locomotion distance, session 8	0.3	0.4	0.9	0.8	-0.2	-0.9	-0.2
Degree of sensitization distance	2.1	2.1	2.7	1.3	-1.6	1.3	-1.6
Degree of sensitization stereotypy	0.3	0.3	0.4	-0.3	0.6	-0.6	0.6
Condit. Reinf. active minus inactive responses	0.5	0.5	1.3	0.0	-0.6	1.2	-0.6
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.9	-0.3	-0.2	1.0	-0.3
Condit. Reinf. active responses	0.3	0.3	0.6	0.2	-0.6	0.8	-0.6
Condit. Reinf. inactive responses	0.5	0.6	0.8	0.9	-0.8	0.3	-0.9
Incentive salience index mean	0.1	0.1	0.2	-0.2	-0.1	0.5	-0.1
Condit. Reinf. lever presses	0.4	0.6	0.8	-0.5	0.8	-0.9	0.7
Time in familiar zone, hab. session 1	0.8	0.7	1.5	-1.0	0.4	1.2	0.4
Time in novel zone, hab. session 1	0.3	0.3	0.4	-0.6	0.5	-0.3	0.6
Total zone transitions, hab. session 1	0.7	0.9	3.2	0.6	0.2	-1.8	0.3
Total locomotion distance, hab. session 1	0.6	0.8	1.6	1.2	-1.0	-0.1	-0.9
Locomotion velocity, hab. session 1	0.5	0.8	1.6	1.3	-0.8	-0.5	-0.7
Time in familiar zone, hab. session 2	0.3	0.3	0.5	-0.7	0.6	0.1	0.5
Time in novel zone, hab. session 2	0.0	0.0	0.0	0.0	-0.0	-0.1	0.1
Total zone transitions, hab. session 2	0.1	0.1	0.2	0.4	-0.4	0.2	-0.3
Total locomotion distance, hab. session 2	1.6	2.1	2.7	1.3	-1.6	1.3	-1.5
Locomotion velocity, hab. session 2	1.3	1.7	2.2	1.3	-1.5	0.9	-1.4
Novel to familiar place preference ratio	0.9	0.9	3.1	-0.7	-0.1	1.8	-0.3
Novelty place preference	0.8	0.8	2.8	-0.7	-0.1	1.7	-0.2
Time in novel zone, NPP test	0.9	1.0	2.9	-1.0	0.1	1.7	0.0
Total zone transitions, NPP test	0.3	0.5	0.9	1.0	-0.8	0.0	-0.6
Total locomotion distance, NPP test	0.9	1.3	1.9	1.2	-1.4	0.7	-1.1
Locomotion velocity, NPP test	1.3	1.9	2.8	1.7	-1.6	0.5	-1.4
Pavlov. Cond. lever latency	0.7	0.9	1.1	0.7	-1.0	1.0	-1.1
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	-0.3	0.2	-0.3	0.3
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.0	-0.2	0.5	-0.3
Pavlov. Cond. index score	0.3	0.4	0.7	-0.8	0.7	-0.2	0.7
Pavlov. Cond. latency score	0.5	0.6	0.8	-0.9	0.8	-0.5	0.9
Pavlov. Cond. lever contacts	0.4	0.4	0.6	-0.5	0.7	-0.7	0.7
Pavlov. Cond. magazine entry number	0.6	0.7	1.2	1.1	-1.0	0.2	-0.8
Pavlov. Cond. intertrial magazine entries	0.6	0.8	1.7	0.3	-0.8	1.3	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	-0.5	0.4	0.1	0.3
Pavlov. Cond. response bias	0.2	0.2	0.3	-0.6	0.6	-0.2	0.5
Bone: apparent density	4.5	7.5	9.6	-2.9	3.1	-1.7	3.0
Bone surface	0.6	1.0	1.5	-1.0	1.2	-0.5	1.1
Bone volume	2.3	3.8	5.2	-2.1	2.3	-1.1	2.1
Bone: connectivity density	1.1	1.7	2.3	-1.5	1.5	-0.5	1.4
Bone: cortical apparent density	2.7	3.5	6.8	2.6	-1.8	-0.6	-1.9
Bone: cortical area	0.0	0.0	0.1	0.1	0.2	-0.2	0.1
Bone: cortical porosity	0.9	1.0	1.1	-1.1	1.1	-0.8	1.0
Bone: cortical porosity	1.4	1.5	1.7	-1.1	1.3	-1.2	1.3
Bone: cortical thickness	0.0	0.0	0.1	0.1	0.2	-0.3	0.0
Bone: cortical thickness	0.0	0.0	0.0	-0.1	0.2	-0.1	0.2
Bone: cortical tissue density	2.6	3.4	6.6	2.6	-1.8	-0.7	-1.9
Bone: elastic displacement	0.4	0.4	0.9	-0.9	0.4	0.6	0.4
Bone: elastic work	0.7	0.9	1.4	-1.2	1.1	-0.2	1.0
Bone: endosteal estimation	0.0	0.1	0.2	-0.4	0.3	-0.0	0.3
Bone: endosteal perimeter	0.0	0.1	0.1	-0.3	0.2	0.2	0.2
Bone: final force	0.1	0.2	0.6	0.3	0.2	-0.8	0.4
Bone: final moment	0.1	0.2	0.4	0.3	0.2	-0.6	0.2
Bone: marrow area	0.0	0.1	0.1	-0.4	0.2	-0.1	0.2
Bone: maximum diameter	0.2	0.3	0.4	-0.6	0.6	-0.3	0.6
Bone: maximum force	0.1	0.1	0.4	0.2	0.3	-0.6	0.3
Bone: maximum moment	0.1	0.1	0.3	0.3	0.2	-0.5	0.2
Bone: minimum diameter	0.1	0.2	0.4	0.7	-0.4	-0.2	-0.4
Bone: periosteal estimation	0.1	0.3	0.4	-0.5	0.6	-0.4	0.5
Bone: periosteal perimeter	0.1	0.1	0.2	-0.5	0.3	0.5	0.2
Bone: post-yield work	0.4	0.6	1.4	-0.1	0.7	-1.2	0.6
Bone: stiffness	0.3	0.4	1.2	0.5	0.0	-1.1	0.3
Bone: tissue strength	0.2	0.2	0.4	0.6	-0.5	0.0	-0.4
Bone: trabecular number	4.1	6.4	8.4	-2.5	2.9	-1.8	2.8
Bone: trabecular spacing	2.1	2.7	3.4	1.8	-1.8	0.9	-1.8
Bone: trabecular thickness	4.4	5.3	7.0	-2.6	2.6	-1.0	2.6
Bone: trabecular tissue density	0.2	0.3	0.9	0.3	0.0	-1.0	0.1
Breakpoint value in progressive ratio session	0.6	0.7	1.2	-1.1	0.9	0.2	0.9
Distance traveled before self-admin	0.4	0.5	0.7	-0.7	0.7	-0.4	0.8
Distance traveled after self-admin	4.1	4.6	5.5	-1.7	2.3	-2.2	2.3
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	0.0	-0.2	0.1	-0.1
Delta time in open arm before/after self-admin	0.3	0.2	0.4	-0.6	0.5	-0.1	0.5
Diff in mean of infusions in LGA sessions	1.0	1.2	2.2	-1.5	1.1	0.3	1.1
Extinction: sum of active levers before priming	2.3	2.3	3.3	-1.8	1.7	0.2	1.8
Active lever presses in extinction session 6	1.3	1.2	3.5	0.1	-1.0	1.9	-0.7
Delta distance traveled before/after self-admin	0.7	0.7	1.7	-0.2	0.8	-1.3	0.7
Delta ambulatory time before/after self-admin	0.4	0.4	1.2	-0.1	0.6	-1.1	0.5
Time in closed arm before self-admin	0.7	0.8	1.4	-1.1	0.5	1.2	0.5
Time in closed arm after self-admin	0.6	0.6	0.9	-0.9	0.9	-0.2	1.0
Time in open arm before self-admin	0.6	0.7	1.0	1.0	-1.0	0.3	-0.9
Time in open arm after self-admin	0.2	0.3	0.3	-0.5	0.5	-0.4	0.6
Sum of active levers in priming session hrs 5-6	1.1	1.1	2.8	-1.2	0.4	1.7	0.4
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.1	-0.4	0.2	0.2	0.2
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	-0.4	0.1	0.5	0.0
Time to tail flick, test, before self-admin	2.7	2.7	3.5	1.6	-1.9	1.1	-1.9
Time to tail flick, test, after self-admin	1.1	1.2	1.3	1.1	-1.1	1.0	-1.1
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	0.2	-0.2	0.1	-0.3
Delta time to tail flick, test, before/after SA	0.7	0.6	0.9	-0.9	0.9	0.2	0.9
Ambulatory time before self-admin	0.1	0.1	0.2	-0.4	0.3	-0.2	0.5
Ambulatory time after self-admin	1.1	1.2	2.7	-0.4	1.0	-1.6	1.1
Total heroin consumption	0.7	0.8	1.5	-1.1	0.5	1.2	0.6
Area under the delay curve	1.4	1.5	4.5	-0.0	-1.0	2.1	-0.8
Delay disc. indifference point, 0s delay	0.5	0.6	1.1	1.0	-0.7	-0.3	-0.8
Delay disc. indifference point, 16s delay	0.8	0.9	2.4	-1.0	-0.0	1.5	0.3
Delay disc. indifference point, 2s delay	0.6	0.7	1.8	0.2	-0.7	1.3	-0.6
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	-0.2	-0.2	0.6	-0.1
Delay disc. indifference point, 4s delay	0.5	0.5	0.8	0.7	-0.9	0.6	-0.7
Delay disc. indifference point, 8s delay	0.9	0.9	2.6	-0.1	-0.8	1.6	-0.6
Delay discount exponential model param	1.3	1.4	4.4	0.1	0.9	-2.1	0.7
Delay discount hyperbolic model param	1.5	1.6	4.2	-0.2	1.2	-2.1	1.0
Fecal boli incidents, locomotor time 1	1.5	1.6	2.1	1.2	-1.4	1.1	-1.5
Change in fecal boli incidents, locomotor task	0.4	0.4	0.7	-0.6	0.7	-0.3	0.8
Time >=10cm from walls, locomotor time 1	4.4	4.4	6.3	2.3	-2.4	0.8	-2.5
Bouts of movement, locomotor time 1	7.0	7.7	8.9	2.3	-2.9	2.9	-3.0
Total resting periods, locomotor time 1	6.5	7.3	8.6	2.4	-2.9	2.5	-2.9
Rest time, locomotor task time 1	0.9	1.0	3.5	-0.3	-0.4	1.9	-0.3
Distance moved, locomotor task time 1	0.2	0.3	0.4	0.5	-0.6	-0.2	-0.6
Vertical activity count, locomotor time 1	0.7	0.7	2.2	-0.3	0.6	-1.5	0.6
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	-0.1	-0.1	0.3	-0.2
Bouts of movement, locomotor time 2	1.4	1.5	1.8	1.3	-1.3	1.0	-1.2
Total resting periods, locomotor time 2	1.1	1.2	1.5	1.2	-1.2	0.9	-1.0
Rest time, locomotor task time 2	0.1	0.1	0.1	-0.4	0.3	0.3	0.4
Distance moved, locomotor task time 2	1.1	1.3	1.9	1.1	-1.4	0.6	-1.4
Vertical activity count, locomotor time 2	0.3	0.3	0.4	0.7	-0.5	-0.5	-0.5
Weight adjusted by age	1.2	1.3	2.2	1.4	-0.7	-1.5	-0.6
Seeking ratio, delayed vs. immediate footshock	1.3	1.5	2.0	-1.2	1.4	-0.7	1.4
Locomotion in novel chamber	4.7	5.8	7.6	2.7	-2.7	1.0	-2.7
Locomotion in novel chamber post-restriction	1.6	1.9	3.0	1.7	-1.7	0.5	-1.4
Progressive ratio	2.1	2.4	3.5	1.0	-1.7	1.9	-1.6
Food seeking constrained by brief footshock	0.2	0.2	0.3	0.4	-0.6	0.2	-0.5
Seeking ratio, punishment vs. effort	0.9	1.1	1.8	-0.6	1.1	-1.3	1.1
Run reversals in cocaine runway, females	0.8	0.8	1.3	1.1	-0.9	-0.5	-0.9
Run reversals in cocaine runway, males	0.0	0.0	0.1	0.1	0.0	0.3	-0.1
Latency to leave start box in cocaine runway	1.1	1.2	2.4	1.5	-0.9	-1.0	-0.7
Latency to leave start box in cocaine runway, F	0.9	1.0	3.6	0.7	0.0	-1.9	0.2
Latency to leave start box in cocaine runway, M	2.9	2.8	3.7	1.9	-1.8	0.9	-1.8
Cd content in liver	0.4	0.4	0.7	-0.4	0.6	-0.6	0.8
Co content in liver	0.3	0.3	0.5	-0.7	0.6	-0.1	0.7
Cu content in liver	0.4	0.5	0.7	-0.8	0.8	-0.4	0.7
Fe content in liver	3.9	4.7	5.7	-2.1	2.4	-1.7	2.4
K content in liver	0.7	0.7	1.2	1.1	-0.7	-0.3	-0.9
Mg content in liver	0.2	0.2	0.3	0.5	-0.1	-0.6	-0.3
Mn content in liver	0.4	0.5	0.9	0.9	-0.6	-0.7	-0.6
Na content in liver	1.0	1.1	1.9	-0.6	1.0	-1.4	1.0
Rb content in liver	1.9	2.3	3.2	1.7	-1.6	0.9	-1.8
Se content in liver	0.0	0.0	0.1	0.2	-0.2	0.1	-0.3
Sr content in liver	0.5	0.5	0.9	0.2	-0.7	1.0	-0.7
Zn content in liver	0.0	0.0	0.0	0.1	-0.1	0.1	0.0