Hub : Genes

Pdlim1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000016166	0.11	0.07	7.2e-07	0.01	0.03	0.03	0.03	4.7e-02	2.1e-04	1.9e-04	3.7e-04
2	Adipose	mRNA stability	ENSRNOG00000016166	0.03	0.02	4.1e-03	0.02	0.01	0	0.01	2.1e-03	7.5e-03	1.4e-01	1.0e-02
3	Brain	gene expression	ENSRNOG00000016166	0.12	0.08	2.4e-11	0.13	0.12	0.12	0.13	2.3e-12	4.1e-11	2.7e-11	7.6e-12
4	Eye	gene expression	ENSRNOG00000016166	0.62	0.19	7.9e-06	0.25	0.24	0.2	0.22	8.7e-05	1.3e-04	6.1e-04	2.6e-04
5	Liver	mRNA stability	ENSRNOG00000016166	0.03	0.02	1.2e-03	0	0.01	0	0.01	8.2e-02	7.6e-03	1.1e-01	6.4e-02
6	OFC	gene expression	ENSRNOG00000016166	0.31	0.18	1.9e-05	0.11	0.17	0.12	0.14	1.8e-03	8.6e-05	1.1e-03	3.9e-04
7	PL	gene expression	ENSRNOG00000016166	0.16	0.09	2.4e-15	0.18	0.2	0.19	0.19	2.2e-13	8.8e-15	2.2e-14	1.3e-14

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
BMI with tail	0.9	2.8	4.0	-0.5	-1.6	-1.7	1.7	1.9	-2.0	-1.8
BMI without tail	1.4	2.9	4.1	-0.8	-1.7	-1.7	1.6	2.0	-2.0	-1.8
Body weight	0.6	2.4	3.1	-1.2	-1.7	-1.5	1.8	1.6	-1.5	-1.6
Epididymis fat weight	1.9	4.4	5.1	-1.6	-2.2	-1.9	2.1	2.3	-2.3	-2.2
Glucose	0.1	0.2	0.4	-0.6	-0.5	-0.3	0.4	0.3	-0.2	-0.4
Heart weight	0.1	0.2	0.9	-0.9	-0.0	-0.4	0.2	-0.1	0.2	-0.1
Left kidney weight	0.2	0.5	1.8	-1.4	0.3	0.1	-0.4	-0.7	0.9	0.4
Right kidney weight	0.4	1.1	2.3	-1.4	0.9	0.2	-0.8	-1.3	1.5	0.8
Tail length	0.2	0.5	2.5	-1.6	-0.6	-0.4	0.4	0.2	-0.0	-0.5
Length with tail	0.1	0.4	1.9	-1.4	-0.1	0.1	-0.1	-0.6	0.8	0.3
Length without tail	0.2	0.5	1.1	-0.8	0.4	0.5	-0.3	-0.9	1.1	0.6
Liver weight, left	0.3	0.5	1.0	-1.0	-0.9	-0.4	0.8	0.5	-0.5	-0.6
Liver weight, right	0.9	1.5	2.7	-1.7	-1.3	-1.3	1.2	1.0	-0.9	-1.1
Parametrial fat weight	0.4	0.7	3.7	-1.9	-0.4	-0.5	0.7	0.0	0.2	-0.4
Retroperitoneal fat weight	0.6	1.9	2.4	-1.4	-1.2	-1.5	1.4	1.3	-1.3	-1.4
Intraocular pressure	0.1	0.1	0.6	0.8	-0.0	-0.3	-0.1	0.3	-0.3	-0.1
Extensor digitorum longus weight	0.1	0.5	0.7	-0.5	-0.9	-0.4	0.8	0.7	-0.8	-0.7
Soleus weight	0.8	2.2	2.8	-1.1	-1.6	-1.3	1.6	1.6	-1.7	-1.5
Tibialis anterior weight	0.3	0.9	1.2	-0.5	-1.1	-0.7	1.0	1.1	-1.1	-1.0
Tibia length	0.1	0.2	1.0	-1.0	-0.2	-0.1	0.3	0.0	0.0	-0.2
Number of licking bursts	2.5	3.0	5.5	2.3	1.7	1.8	-1.6	-1.5	1.4	1.7
Food consumed during 24 hour testing period	0.7	0.8	1.4	0.2	0.9	0.9	-0.8	-1.1	1.2	1.0
Times rat made contact with spout	0.3	0.3	0.6	0.6	0.5	0.8	-0.3	-0.5	0.4	0.5
Mean time between licks in bursts	0.2	0.2	0.5	-0.7	-0.5	-0.3	0.6	0.3	-0.3	-0.4
Mean num. licks in bursts	2.3	2.7	4.1	-2.0	-1.6	-1.6	1.7	1.5	-1.4	-1.6
Std. dev. time between licks in bursts	0.3	0.4	0.7	0.9	0.6	0.6	-0.5	-0.6	0.6	0.6
Water consumed over 24 hours	0.2	0.3	0.6	0.8	0.4	0.7	-0.3	-0.4	0.4	0.6
Indifference point 0 sec	0.2	0.3	0.5	-0.3	0.7	0.2	-0.4	-0.6	0.7	0.5
Indifference point AUC	4.4	5.2	6.5	1.6	2.3	1.9	-2.4	-2.5	2.6	2.4
Indifference point function ln k	3.8	5.3	6.5	-1.5	-2.5	-2.1	2.4	2.5	-2.6	-2.4
Indifference point function log k	3.8	5.3	6.5	-1.5	-2.5	-2.1	2.4	2.5	-2.6	-2.4
Delay discounting total patch changes 0 sec	0.1	0.2	0.3	-0.6	0.4	0.1	-0.2	-0.5	0.6	0.3
Delay discounting total patch changes 12 sec	3.4	4.5	5.8	1.3	2.4	1.8	-2.3	-2.3	2.3	2.2
Delay discounting total patch changes 18 sec	1.1	1.4	1.7	1.2	1.3	0.8	-1.1	-1.2	1.3	1.2
Delay discounting total patch changes 24 sec	0.3	0.4	0.8	-0.1	0.6	0.5	-0.4	-0.8	0.9	0.7
Delay discounting total patch changes 6 sec	3.7	5.6	7.7	1.3	2.6	2.0	-2.4	-2.7	2.8	2.5
Delay discounting time to switch 0 sec	0.7	1.1	1.7	1.3	1.2	1.0	-1.1	-0.9	0.8	1.0
Delay discounting water rate 0 sec	1.0	1.5	2.8	-1.3	-1.1	-1.7	1.1	1.1	-1.0	-1.2
Delay discounting water rate 12 sec	0.3	0.5	1.2	-1.1	-0.6	-0.7	0.8	0.6	-0.5	-0.6
Delay discounting water rate 18 sec	0.2	0.3	0.6	-0.8	-0.5	-0.6	0.5	0.4	-0.4	-0.5
Delay discounting water rate 24 sec	0.5	0.6	1.3	-0.7	-0.7	-1.1	0.6	0.7	-0.7	-0.8
Delay discounting water rate 6 sec	0.2	0.2	0.4	-0.5	-0.4	-0.6	0.6	0.4	-0.4	-0.4
Locomotor activity	0.0	0.0	0.0	-0.2	0.2	-0.1	-0.0	-0.1	0.2	0.1
Locomotor testing distance	0.0	0.0	0.1	-0.3	0.2	-0.3	-0.1	-0.1	0.1	-0.0
Locomotor testing rearing	0.2	0.3	0.5	-0.1	-0.6	-0.7	0.5	0.7	-0.7	-0.6
Light reinforcement 1	0.1	0.2	0.3	0.6	0.5	0.4	-0.4	-0.2	0.1	0.3
Light reinforcement 2	2.3	3.0	4.2	2.0	1.8	1.8	-1.8	-1.6	1.4	1.7
Reaction time number correct	1.1	1.6	2.5	0.0	-1.5	-1.0	1.1	1.5	-1.6	-1.3
Reaction time mean minus median	0.4	0.6	1.7	-1.3	-0.7	-0.5	0.8	0.5	-0.3	-0.7
Reaction time mean minus median AUC	0.4	0.5	1.0	-1.0	-0.8	-0.7	0.8	0.6	-0.5	-0.7
Reaction time num false alarms	0.1	0.1	0.5	-0.7	-0.4	-0.2	0.1	0.0	0.0	-0.1
Reaction time num false alarms AUC	0.2	0.3	1.1	-1.1	-0.6	-0.4	0.2	0.1	-0.0	-0.3
Reaction time trials correct on left	1.1	1.6	2.5	0.0	-1.5	-1.0	1.1	1.5	-1.6	-1.3
Reaction time trials on left	1.1	1.6	2.5	-0.0	-1.5	-1.0	1.1	1.5	-1.6	-1.3
Reaction time mean	0.2	0.3	0.5	-0.6	0.4	0.4	-0.2	-0.6	0.7	0.5
Reaction time mean AUC	0.3	0.4	0.8	-0.4	0.6	0.6	-0.4	-0.8	0.9	0.6
Median of all reaction times	0.2	0.3	0.5	-0.2	0.5	0.5	-0.4	-0.7	0.7	0.6
Reaction time omissions	1.4	1.8	3.5	-1.9	-1.5	-1.1	1.5	1.1	-0.9	-1.3
Reaction time false alarm rate	0.2	0.3	0.9	-1.0	0.2	0.1	-0.3	-0.6	0.7	0.4
Reaction time premature initiation rate	0.4	0.5	3.0	-1.7	-0.1	0.2	0.1	-0.4	0.5	0.1
Reaction time premature initiations	0.5	0.6	2.9	-1.7	-0.8	-0.3	0.6	0.4	-0.2	-0.5
Std. dev. reaction times	0.5	0.6	2.9	-1.7	-0.7	-0.4	0.7	0.3	-0.1	-0.5
Reaction time trials completed	1.1	1.6	2.5	-0.0	-1.5	-1.0	1.1	1.5	-1.6	-1.3
Reaction time trials AUC	1.0	1.4	2.3	0.1	-1.4	-1.0	1.0	1.4	-1.5	-1.2
Social response proportion	1.5	1.6	2.6	-0.2	-1.2	-1.0	1.6	1.4	-1.6	-1.2
Social responses	1.2	1.6	2.1	-1.0	-1.2	-1.5	1.3	1.3	-1.3	-1.3
Social time	0.0	0.1	0.2	-0.4	-0.0	-0.1	-0.3	-0.2	0.3	0.1
Conditioned locomotion	1.6	1.9	2.3	-0.8	-1.4	-1.5	1.4	1.5	-1.5	-1.5
Cocaine response after cond. corrected	0.2	0.2	0.6	0.8	0.4	0.1	-0.3	-0.3	0.2	0.4
Cocaine response after cond. not corrected	0.3	0.3	0.4	0.4	0.6	0.5	-0.5	-0.6	0.6	0.6
Cocaine response before conditioning	0.9	1.1	1.7	-0.3	0.9	1.3	-1.0	-1.2	1.3	1.1
Saline control response	2.0	2.7	3.6	0.8	1.8	1.5	-1.6	-1.8	1.9	1.7
Condit. Reinf. active minus inactive responses	2.3	2.9	3.3	-1.2	-1.7	-1.7	1.8	1.8	-1.8	-1.8
Condit. Reinf. active-inactive response ratio	1.2	1.2	1.8	-0.5	-1.1	-1.1	1.1	1.3	-1.3	-1.2
Condit. Reinf. active responses	1.7	2.4	3.3	-1.8	-1.5	-1.6	1.6	1.4	-1.3	-1.5
Condit. Reinf. inactive responses	0.3	0.4	2.3	-1.5	-0.2	-0.5	0.4	-0.1	0.3	-0.2
Condit. Reinf. lever presses	0.1	0.2	0.4	-0.5	0.3	0.3	-0.3	-0.5	0.6	0.3
Condit. Reinf. lever reinforcers received	0.9	1.2	1.9	-1.4	-1.1	-1.2	1.1	1.0	-0.9	-1.1
Pavlov. Cond. lever latency	0.8	1.1	2.0	0.1	-1.1	-0.7	1.1	1.3	-1.4	-1.1
Pavlov. Cond. magazine entry latency	0.4	0.4	0.8	-0.2	0.5	0.6	-0.5	-0.8	0.9	0.6
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	-0.5	0.3	-0.0	-0.3	-0.4	0.5	0.3
Pavlov. Cond. index score	0.9	1.2	2.1	-0.0	1.0	1.0	-1.1	-1.3	1.4	1.1
Pavlov. Cond. latency score	0.9	1.2	2.1	-0.0	1.1	1.0	-1.1	-1.3	1.4	1.1
Pavlov. Cond. lever contacts	0.5	0.7	1.3	-0.3	0.8	0.5	-0.8	-1.0	1.1	0.8
Pavlov. Cond. magazine entry number	2.3	2.8	4.4	-0.2	-1.6	-1.7	1.6	2.0	-2.1	-1.8
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.6	0.1	-0.9	-0.8	0.9	1.1	-1.2	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	2.1	-0.0	1.1	1.0	-1.1	-1.3	1.5	1.1
Pavlov. Cond. response bias	0.8	1.1	2.0	-0.2	1.0	0.9	-1.0	-1.3	1.4	1.1
Conditioned reinforcement - actives	0.2	0.2	0.4	-0.0	0.3	0.7	-0.4	-0.6	0.6	0.5
Conditioned reinforcement - inactives	0.3	0.4	0.8	0.3	0.9	0.2	-0.6	-0.7	0.7	0.7
Conditioned locomotion	0.8	0.9	1.3	0.4	0.9	1.0	-0.9	-1.1	1.1	1.1
Intermittent access intake day 1-15 change	2.2	2.1	2.9	-0.9	-1.7	-1.3	1.7	1.5	-1.5	-1.5
Intermittent access intake escalation	2.5	2.4	3.2	-0.9	-1.8	-1.3	1.8	1.7	-1.7	-1.6
Intermittent access intake escalation 2	1.8	1.8	2.4	-0.4	-1.5	-1.0	1.5	1.5	-1.5	-1.4
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.4	0.4	-0.5	-0.1	0.4	0.5	-0.6	-0.4
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.0	-0.1	-0.0	-0.0	0.1	0.1	-0.1	-0.1
Intermitt. access escalation Index	2.0	1.8	2.1	-1.0	-1.3	-1.4	1.5	1.4	-1.4	-1.4
Intermittent access day 1 total infusions	0.0	0.0	0.2	-0.1	-0.1	-0.4	0.1	0.2	-0.2	-0.2
Intermittent access day 15 total infusions	2.4	2.7	3.1	-1.8	-1.7	-1.6	1.7	1.6	-1.5	-1.6
Intermittent access terminal intake (last 3 days)	1.0	1.1	1.3	-1.0	-1.1	-1.0	1.1	1.0	-1.0	-1.0
Intermittent access total infusions	0.7	0.8	0.9	-0.9	-1.0	-0.9	0.8	0.9	-0.9	-0.9
Intermittent access day 1 locomotion	0.3	0.3	0.4	-0.6	-0.5	-0.6	0.4	0.5	-0.4	-0.6
Intermittent access day 15 total locomotion	0.8	0.8	1.3	0.4	0.9	1.1	-0.9	-1.0	1.0	1.0
Intermittent access total locomotion	0.4	0.5	0.6	0.5	0.7	0.8	-0.8	-0.7	0.7	0.7
Intermittent access standard deviation	1.5	1.6	2.2	-1.3	-1.3	-1.2	1.5	1.2	-1.1	-1.2
Cocaine induced anxiety	0.0	0.0	0.1	0.2	-0.2	-0.1	-0.2	0.2	-0.2	-0.2
Post-drug Anxiety	0.1	0.1	0.5	0.7	0.3	0.4	-0.5	-0.1	0.0	0.2
Baseline Anxiety	0.0	0.0	0.1	0.2	0.3	0.2	0.1	-0.1	0.1	0.2
Lifetime Intake	0.2	0.2	0.4	-0.4	-0.4	-0.6	0.3	0.4	-0.4	-0.4
Incentive Sensitization - Responses	0.3	0.3	0.6	-0.1	-0.5	-0.3	0.8	0.5	-0.6	-0.5
Incentive Sensitization - Breakpoint	0.2	0.2	0.5	-0.2	-0.3	-0.3	0.7	0.4	-0.4	-0.3
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	0.4	-0.2	-0.2	0.2	0.3	-0.3	-0.2
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	0.4	-0.3	-0.2	0.2	0.4	-0.4	-0.2
Progressive ratio test 1 inactive lever presses	1.8	1.9	3.1	-0.3	-1.2	-1.8	1.4	1.5	-1.5	-1.5
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	0.4	-0.1	0.0	0.2	0.2	-0.2	-0.1
Progressive ratio test 2 breakpoint	0.0	0.0	0.1	0.3	-0.1	0.0	0.2	0.1	-0.2	-0.0
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.2	0.4	-0.0	0.1	0.1	0.2	-0.3	0.0
Total sessions with >9 infusions	0.3	0.3	0.6	0.7	0.4	0.3	-0.8	-0.4	0.4	0.5
Short access day 1 total inactive lever presses	1.8	2.0	3.3	0.5	-1.0	-1.7	1.4	1.7	-1.8	-1.4
Short access day 10 total inactive lever presses	0.0	0.0	0.1	0.3	0.3	-0.3	0.2	-0.0	0.0	0.0
Short access day 1 total infusions	0.7	0.8	1.3	1.1	1.0	0.3	-1.1	-0.8	0.7	0.8
Short access day 10 total infusions	0.1	0.1	0.2	-0.1	0.3	0.2	-0.5	-0.4	0.4	0.3
Short access total infusions	0.2	0.2	0.5	0.5	0.5	-0.1	-0.7	-0.3	0.3	0.3
Short access day 1 locomotion	0.1	0.1	0.5	0.7	-0.2	-0.2	-0.2	0.3	-0.4	-0.1
Short access day 10 total locomotion	0.2	0.2	0.4	0.6	0.5	0.3	-0.6	-0.3	0.3	0.4
Short access total locomotion	0.3	0.3	1.2	1.1	0.4	0.2	-0.6	-0.2	0.2	0.3
Compulsive drug intake	3.5	3.5	4.8	-1.7	-1.6	-2.2	2.2	1.8	-1.7	-1.9
One hour access (0.3 mA shock)	0.6	0.7	0.8	-0.7	-0.9	-0.8	0.8	0.9	-0.9	-0.8
One hour access (shock baseline)	0.2	0.2	0.4	-0.4	-0.6	-0.4	0.1	0.5	-0.5	-0.4
Number of responses in last shaping day	0.1	0.1	0.2	0.3	-0.3	-0.2	0.4	0.4	-0.4	-0.3
Context. condit. distance diff. score	0.3	0.3	0.6	-0.6	-0.5	-0.8	0.5	0.5	-0.5	-0.5
Locomotion velocity, session 1	6.0	6.4	7.4	2.7	2.6	2.4	-2.7	-2.4	2.3	2.6
Locomotion distance, session 1	1.6	2.1	2.6	1.3	1.5	1.3	-1.6	-1.5	1.5	1.5
Locomotion velocity, session 2	1.0	1.1	1.3	1.1	1.1	1.0	-1.2	-1.0	0.9	1.1
Locomotion distance, session 2	0.7	1.0	1.3	1.1	0.9	1.1	-1.0	-0.9	0.8	1.0
Locomotion velocity, session 3	0.1	0.1	0.5	-0.7	0.1	0.1	0.0	-0.3	0.4	0.2
Locomotion distance, session 3	0.5	0.6	3.3	-1.8	-0.5	-0.4	0.6	-0.0	0.2	-0.3
Stereotopy head waving bouts, day 3	0.3	0.3	0.5	0.5	0.7	0.5	-0.7	-0.5	0.5	0.6
Stereotopy head waving duration, day 3	0.5	0.6	1.1	1.1	0.8	0.6	-0.9	-0.6	0.5	0.7
Locomotion velocity, session 7	0.8	0.9	1.6	-1.3	-0.9	-0.9	1.0	0.8	-0.7	-0.8
Locomotion distance, session 7	0.9	1.2	1.6	-1.1	-1.1	-1.0	1.3	1.0	-1.0	-1.0
Stereotopy head waving bouts, day 7	2.9	3.3	4.4	1.4	2.1	1.4	-2.0	-1.9	1.9	1.9
Stereotopy head waving duration, day 7	0.7	0.9	1.4	0.5	1.2	0.7	-1.1	-1.0	1.0	1.0
Locomotion velocity, session 8	0.0	0.0	0.1	-0.1	0.2	-0.1	-0.2	-0.2	0.3	0.2
Locomotion distance, session 8	0.0	0.1	0.1	0.4	0.3	0.0	-0.3	-0.2	0.1	0.3
Degree of sensitization distance	0.4	0.4	2.0	1.4	0.3	0.4	-0.4	0.0	-0.2	0.2
Degree of sensitization stereotypy	2.3	2.5	3.3	1.0	1.8	1.2	-1.7	-1.7	1.7	1.6
Condit. Reinf. active minus inactive responses	0.4	0.4	0.7	0.1	0.6	0.6	-0.7	-0.8	0.9	0.8
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.3	0.2	0.1	-0.3	-0.4	0.4	0.3
Condit. Reinf. active responses	0.2	0.3	0.5	0.1	0.4	0.6	-0.4	-0.6	0.7	0.6
Condit. Reinf. inactive responses	0.3	0.4	0.7	0.8	0.5	0.9	-0.4	-0.5	0.5	0.6
Incentive salience index mean	0.4	0.5	0.9	-0.3	0.6	0.5	-0.6	-0.9	1.0	0.7
Condit. Reinf. lever presses	0.4	0.5	0.9	-0.2	0.7	0.5	-0.7	-0.9	0.9	0.7
Time in familiar zone, hab. session 1	0.2	0.2	0.3	0.3	-0.3	-0.5	0.4	0.5	-0.5	-0.4
Time in novel zone, hab. session 1	0.5	0.5	0.6	0.5	0.6	0.7	-0.8	-0.7	0.7	0.7
Total zone transitions, hab. session 1	0.2	0.3	0.5	0.7	0.6	0.4	-0.6	-0.5	0.5	0.6
Total locomotion distance, hab. session 1	2.1	3.0	3.5	1.2	1.8	1.6	-1.9	-1.8	1.8	1.8
Locomotion velocity, hab. session 1	3.2	4.6	5.5	1.3	2.2	2.1	-2.3	-2.3	2.3	2.3
Time in familiar zone, hab. session 2	0.5	0.5	1.2	-0.3	-0.5	-1.1	0.6	0.7	-0.7	-0.7
Time in novel zone, hab. session 2	0.7	0.7	1.4	0.4	0.7	1.2	-0.8	-0.9	0.9	0.9
Total zone transitions, hab. session 2	0.2	0.2	0.3	0.4	0.4	0.3	-0.5	-0.5	0.5	0.5
Total locomotion distance, hab. session 2	0.5	0.6	0.8	0.4	0.8	0.6	-0.9	-0.9	0.9	0.9
Locomotion velocity, hab. session 2	0.7	0.9	1.1	0.7	1.0	0.8	-1.1	-1.0	1.0	1.0
Novel to familiar place preference ratio	0.4	0.5	2.3	1.5	0.4	0.6	-0.5	-0.0	-0.2	0.3
Novelty place preference	0.4	0.4	2.2	1.5	0.3	0.6	-0.4	0.1	-0.2	0.2
Time in novel zone, NPP test	0.4	0.4	2.2	1.5	0.3	0.7	-0.4	0.0	-0.2	0.2
Total zone transitions, NPP test	0.4	0.5	0.9	-0.1	0.6	0.6	-0.7	-0.9	1.0	0.8
Total locomotion distance, NPP test	2.7	3.8	4.9	0.8	1.9	1.8	-2.2	-2.2	2.2	2.1
Locomotion velocity, NPP test	2.1	3.0	4.3	0.5	1.8	1.5	-2.0	-2.0	2.1	1.9
Pavlov. Cond. lever latency	0.2	0.2	0.4	0.4	-0.4	-0.1	0.4	0.6	-0.6	-0.4
Pavlov. Cond. magazine entry latency	0.8	1.0	1.9	-0.8	0.8	0.8	-0.7	-1.2	1.4	1.0
Pavlov. Cond. change in total contacts	0.2	0.2	1.0	-1.0	0.2	0.0	-0.2	-0.4	0.5	0.2
Pavlov. Cond. index score	0.8	1.0	1.9	-0.4	1.0	0.9	-0.9	-1.3	1.4	1.1
Pavlov. Cond. latency score	0.5	0.7	1.3	-0.6	0.8	0.6	-0.7	-1.0	1.1	0.8
Pavlov. Cond. lever contacts	0.5	0.6	1.2	-0.5	0.7	0.5	-0.7	-1.0	1.1	0.8
Pavlov. Cond. magazine entry number	0.2	0.2	0.8	0.9	-0.1	-0.3	0.1	0.4	-0.5	-0.2
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.5	0.7	0.4	0.5	-0.4	-0.5	0.5	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.8	-0.4	0.9	0.9	-0.8	-1.2	1.3	1.0
Pavlov. Cond. response bias	0.4	0.5	1.0	-0.8	0.5	0.6	-0.4	-0.9	1.0	0.7
Bone: apparent density	0.6	1.0	1.6	-0.1	-1.0	-1.0	1.0	1.2	-1.3	-1.1
Bone surface	1.5	2.7	3.4	-0.9	-1.6	-1.7	1.7	1.8	-1.8	-1.7
Bone volume	1.7	2.8	3.4	-1.1	-1.7	-1.8	1.7	1.8	-1.8	-1.8
Bone: connectivity density	1.9	3.0	4.6	-0.4	-1.7	-1.7	1.7	2.0	-2.1	-1.8
Bone: cortical apparent density	2.3	3.0	3.9	2.0	1.7	1.7	-1.8	-1.6	1.5	1.7
Bone: cortical area	1.5	2.3	5.6	-2.4	-1.4	-1.6	1.4	1.1	-0.9	-1.3
Bone: cortical porosity	0.5	0.5	2.0	1.4	0.7	0.7	-0.5	-0.3	0.2	0.6
Bone: cortical porosity	0.1	0.1	0.5	0.7	0.3	0.4	-0.2	-0.1	-0.0	0.2
Bone: cortical thickness	0.6	0.9	1.9	-0.7	0.9	0.6	-0.8	-1.2	1.4	1.0
Bone: cortical thickness	2.5	2.9	3.9	0.6	1.9	1.5	-1.8	-1.9	2.0	1.8
Bone: cortical tissue density	2.3	3.0	4.5	2.1	1.7	1.7	-1.8	-1.6	1.4	1.7
Bone: elastic displacement	0.4	0.4	0.9	0.9	-0.4	-0.4	0.4	0.7	-0.9	-0.5
Bone: elastic work	0.3	0.4	0.7	0.4	-0.5	-0.7	0.6	0.8	-0.8	-0.6
Bone: endosteal estimation	3.3	7.1	8.1	-1.9	-2.7	-2.7	2.7	2.8	-2.8	-2.8
Bone: endosteal perimeter	3.5	7.1	8.1	-2.0	-2.8	-2.6	2.7	2.9	-2.8	-2.8
Bone: final force	0.1	0.1	0.7	-0.9	-0.2	-0.3	0.1	0.0	0.1	-0.1
Bone: final moment	0.2	0.3	1.1	-1.0	-0.4	-0.5	0.4	0.2	-0.1	-0.3
Bone: marrow area	3.3	7.1	8.2	-1.9	-2.7	-2.7	2.7	2.9	-2.9	-2.8
Bone: maximum diameter	4.3	7.8	8.4	-2.4	-2.8	-2.9	2.9	2.9	-2.8	-2.9
Bone: maximum force	0.1	0.2	0.5	-0.7	-0.5	-0.6	0.4	0.4	-0.4	-0.4
Bone: maximum moment	0.3	0.5	0.9	-0.9	-0.7	-0.8	0.6	0.6	-0.5	-0.6
Bone: minimum diameter	8.2	15.1	16.8	-3.8	-3.9	-4.1	3.9	3.8	-3.7	-4.0
Bone: periosteal estimation	2.3	4.8	5.3	-2.1	-2.2	-2.3	2.2	2.2	-2.1	-2.2
Bone: periosteal perimeter	3.2	5.2	5.6	-2.0	-2.3	-2.4	2.3	2.3	-2.3	-2.4
Bone: post-yield work	0.4	0.5	0.9	-0.9	-0.6	-0.7	0.6	0.6	-0.6	-0.7
Bone: stiffness	0.2	0.4	1.2	-1.1	-0.6	-0.5	0.5	0.3	-0.3	-0.5
Bone: tissue strength	0.2	0.2	0.2	-0.3	-0.3	-0.5	0.5	0.4	-0.3	-0.4
Bone: trabecular number	0.7	1.1	1.5	-0.4	-1.0	-1.1	1.0	1.2	-1.2	-1.1
Bone: trabecular spacing	0.2	0.2	0.5	-0.7	0.3	0.4	-0.3	-0.6	0.7	0.4
Bone: trabecular thickness	1.2	1.4	2.0	-1.1	-1.2	-1.4	1.1	1.2	-1.2	-1.2
Bone: trabecular tissue density	0.6	0.8	1.2	-0.3	-0.9	-0.9	0.7	1.1	-1.1	-1.0
Breakpoint value in progressive ratio session	0.9	1.0	1.5	0.5	1.2	0.3	-1.1	-1.1	1.2	1.0
Distance traveled before self-admin	0.1	0.1	0.3	0.4	0.2	0.4	-0.5	-0.1	0.0	0.2
Distance traveled after self-admin	0.4	0.5	0.9	-0.2	-0.8	-0.3	0.6	0.9	-0.9	-0.7
Delta time in closed arm before/after self-admin	0.1	0.1	0.6	-0.7	0.0	-0.1	-0.2	-0.2	0.4	0.1
Delta time in open arm before/after self-admin	1.1	1.1	2.0	-0.3	-0.8	-1.4	1.0	1.1	-1.2	-1.0
Diff in mean of infusions in LGA sessions	0.7	0.8	1.9	-0.3	-0.7	-1.4	1.0	0.8	-0.8	-0.9
Extinction: sum of active levers before priming	0.3	0.3	1.2	-0.4	-0.3	-1.1	0.3	0.5	-0.4	-0.6
Active lever presses in extinction session 6	0.4	0.4	1.0	1.0	0.0	-0.8	0.1	0.6	-0.7	-0.4
Delta distance traveled before/after self-admin	2.4	2.6	3.3	-0.6	-1.6	-1.6	1.8	1.8	-1.8	-1.7
Delta ambulatory time before/after self-admin	3.3	3.6	4.5	-0.9	-2.0	-1.8	2.1	2.1	-2.1	-2.0
Time in closed arm before self-admin	0.1	0.1	0.6	0.8	0.0	0.4	-0.3	0.0	-0.1	0.1
Time in closed arm after self-admin	0.8	0.8	1.6	0.9	0.4	1.3	-1.1	-0.7	0.7	0.8
Time in open arm before self-admin	0.1	0.1	0.1	0.2	-0.2	0.0	0.3	0.3	-0.4	-0.2
Time in open arm after self-admin	0.9	1.0	2.1	-0.5	-0.6	-1.4	1.0	1.0	-1.0	-1.0
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.4	0.6	0.2	-0.2	-0.2	-0.0	-0.0	0.1
Time to tail flick, vehicle, before self-admin	0.5	0.5	1.2	1.1	0.8	0.8	-0.7	-0.5	0.4	0.7
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.4	-0.0	-0.7	-0.5	0.5	0.6	-0.6	-0.5
Time to tail flick, test, before self-admin	0.7	0.7	0.9	-0.5	-0.8	-0.9	0.8	0.9	-0.9	-0.9
Time to tail flick, test, after self-admin	0.7	0.7	1.1	0.4	-0.9	-0.9	0.7	1.0	-1.1	-0.8
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.6	-0.5	-0.8	-0.6	0.7	0.5	-0.5	-0.6
Delta time to tail flick, test, before/after SA	0.0	0.0	0.2	0.4	-0.0	0.1	-0.1	0.0	-0.0	0.0
Ambulatory time before self-admin	0.3	0.3	0.7	0.6	0.4	0.7	-0.8	-0.2	0.2	0.4
Ambulatory time after self-admin	0.5	0.5	1.1	0.4	-0.7	-0.3	0.7	0.9	-1.1	-0.7
Total heroin consumption	0.4	0.5	1.1	-0.1	1.1	-0.7	-0.7	-0.6	0.7	0.4
Area under the delay curve	1.4	1.5	2.8	1.7	1.3	1.0	-1.2	-1.1	1.1	1.3
Delay disc. indifference point, 0s delay	0.6	0.6	1.1	0.4	-0.6	-0.8	0.6	1.0	-1.0	-0.8
Delay disc. indifference point, 16s delay	1.2	1.2	1.4	1.2	1.2	1.0	-1.1	-1.1	1.0	1.1
Delay disc. indifference point, 2s delay	0.3	0.3	1.9	1.4	0.2	0.1	-0.4	0.1	-0.2	0.2
Delay disc. indifference point, 24s delay	4.2	4.1	4.7	1.7	2.1	2.0	-1.9	-2.2	2.1	2.2
Delay disc. indifference point, 4s delay	0.9	0.9	1.8	1.3	0.9	0.6	-1.0	-0.9	0.8	1.0
Delay disc. indifference point, 8s delay	3.8	4.0	4.9	2.2	2.1	1.6	-2.0	-2.0	1.9	2.1
Delay discount exponential model param	1.6	1.7	2.7	-1.7	-1.3	-1.0	1.2	1.2	-1.1	-1.3
Delay discount hyperbolic model param	1.1	1.1	2.4	-1.5	-1.1	-0.8	1.0	1.0	-0.9	-1.1
Fecal boli incidents, locomotor time 1	0.1	0.1	0.3	0.6	0.6	0.2	-0.1	-0.3	0.2	0.4
Change in fecal boli incidents, locomotor task	0.1	0.1	0.4	-0.4	0.1	0.6	-0.0	-0.1	0.1	0.0
Time >=10cm from walls, locomotor time 1	0.8	0.9	2.5	-1.6	0.5	0.8	-0.3	-0.9	1.1	0.6
Bouts of movement, locomotor time 1	2.3	2.6	3.0	1.7	1.7	1.5	-1.7	-1.5	1.5	1.6
Total resting periods, locomotor time 1	3.7	4.2	4.8	1.8	2.2	1.9	-2.1	-2.1	2.0	2.1
Rest time, locomotor task time 1	1.5	1.6	4.0	2.0	1.3	0.8	-1.3	-1.0	0.9	1.2
Distance moved, locomotor task time 1	1.8	1.9	6.1	-2.5	-1.4	-1.1	1.3	0.9	-0.7	-1.1
Vertical activity count, locomotor time 1	0.9	0.9	4.0	-2.0	-0.9	-0.3	1.0	0.5	-0.3	-0.7
Time >=10cm from walls, locomotor time 2	0.4	0.4	0.6	-0.6	0.5	0.7	-0.5	-0.7	0.8	0.5
Bouts of movement, locomotor time 2	4.5	4.8	5.6	2.4	2.2	2.3	-2.2	-2.1	1.9	2.2
Total resting periods, locomotor time 2	5.2	5.6	6.4	2.5	2.4	2.4	-2.4	-2.2	2.1	2.4
Rest time, locomotor task time 2	2.6	3.0	3.6	1.9	1.9	1.4	-1.7	-1.7	1.7	1.8
Distance moved, locomotor task time 2	1.5	1.8	3.8	-1.9	-1.5	-1.4	1.1	1.1	-0.9	-1.2
Vertical activity count, locomotor time 2	0.3	0.3	0.9	-1.0	-0.5	-0.6	0.5	0.3	-0.2	-0.4
Weight adjusted by age	0.4	0.5	1.0	0.1	-0.6	-0.5	0.8	0.9	-1.0	-0.7
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.4	-0.7	-0.2	0.3	-0.3	-0.2	0.3	0.1
Locomotion in novel chamber	1.6	2.0	2.9	-0.6	-1.2	-1.4	1.5	1.7	-1.7	-1.5
Locomotion in novel chamber post-restriction	0.1	0.2	0.3	-0.3	0.5	0.2	-0.3	-0.5	0.5	0.4
Progressive ratio	0.8	0.9	1.3	-1.1	-0.8	-0.9	1.0	0.9	-0.9	-1.0
Food seeking constrained by brief footshock	0.2	0.3	0.6	-0.4	0.3	0.3	-0.6	-0.6	0.7	0.5
Seeking ratio, punishment vs. effort	1.1	1.4	1.8	0.8	1.1	1.0	-1.3	-1.3	1.3	1.3
Run reversals in cocaine runway, females	0.8	0.8	2.4	1.6	0.7	1.0	-0.6	-0.6	0.5	0.8
Run reversals in cocaine runway, males	2.8	2.7	3.8	0.6	1.8	1.4	-1.8	-1.9	1.9	1.7
Latency to leave start box in cocaine runway	4.1	4.5	5.6	-1.2	-2.3	-1.9	2.2	2.3	-2.4	-2.2
Latency to leave start box in cocaine runway, F	4.7	5.2	6.8	-1.1	-2.4	-2.2	2.4	2.5	-2.6	-2.4
Latency to leave start box in cocaine runway, M	0.7	0.7	1.2	-0.8	-1.1	-0.3	0.8	0.8	-0.8	-0.8
Cd content in liver	0.4	0.4	0.6	0.0	0.6	0.8	-0.6	-0.7	0.8	0.7
Co content in liver	0.3	0.4	1.0	-1.0	-0.6	-0.6	0.6	0.4	-0.4	-0.5
Cu content in liver	7.1	8.6	9.4	2.8	3.1	2.9	-3.1	-2.9	2.8	3.0
Fe content in liver	1.3	1.5	1.7	1.3	1.3	1.3	-1.3	-1.2	1.1	1.3
K content in liver	0.7	0.7	0.9	0.9	0.9	0.9	-0.9	-0.7	0.7	0.8
Mg content in liver	1.2	1.2	1.7	1.3	1.2	1.1	-1.2	-1.0	0.9	1.1
Mn content in liver	7.7	8.8	10.2	3.2	3.1	3.0	-3.1	-2.8	2.6	3.0
Na content in liver	1.9	2.1	2.6	1.6	1.6	1.2	-1.6	-1.3	1.3	1.4
Rb content in liver	0.2	0.3	0.4	0.4	0.6	0.5	-0.6	-0.5	0.5	0.5
Se content in liver	20.0	24.2	28.3	4.2	5.0	5.3	-5.0	-4.9	4.8	5.1
Sr content in liver	0.1	0.1	0.1	0.2	0.3	0.4	-0.3	-0.3	0.3	0.3
Zn content in liver	0.9	1.0	1.0	1.0	1.0	1.0	-1.0	-1.0	1.0	1.0