Gtse1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000016148	0.17	0.18	3.7e-03	-0	0	0.03	-0	9.6e-01	1.5e-01	5.7e-04	9.8e-01
2	Brain	gene expression	ENSRNOG00000016148	0.08	0.1	5.8e-03	0.02	0.02	0.02	0.02	4.7e-03	4.6e-03	5.9e-03	9.4e-03
3	Brain	intron excision ratio	chr7:116965444:116965769	0.03	0.02	4.0e-04	0.04	0.04	0.04	0.04	9.9e-05	8.2e-05	4.5e-05	5.2e-05
4	LHb	gene expression	ENSRNOG00000016148	0.2	0.11	3.3e-03	0.11	0.02	0.01	0.09	1.7e-03	8.8e-02	1.7e-01	4.1e-03
5	Liver	gene expression	ENSRNOG00000016148	0.44	0.1	0.0e+00	0.44	0.46	0.45	0.46	1.3e-53	2.7e-56	7.8e-56	8.2e-57

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
BMI with tail	1.8	5.8	13.2	-2.5	0.2	3.6	-2.0	-2.4
BMI without tail	1.8	3.8	7.4	-2.7	-1.8	2.0	-2.0	0.4
Body weight	1.5	6.1	12.9	-1.4	-1.8	3.6	-3.5	-0.5
Epididymis fat weight	0.2	0.6	1.3	1.1	-0.4	0.6	-1.0	0.0
Glucose	0.2	0.4	1.0	-0.7	1.0	-0.4	0.0	-0.4
Heart weight	1.1	1.6	4.1	2.0	0.7	-0.2	1.5	-1.1
Left kidney weight	5.7	16.2	47.2	-0.6	-2.5	6.9	-4.4	-2.8
Right kidney weight	5.2	14.8	43.7	-0.9	-1.8	6.6	-3.9	-3.3
Tail length	1.2	3.6	8.0	-1.1	-2.5	-0.7	-1.4	2.8
Length with tail	0.7	2.7	5.5	-0.2	-2.1	0.9	-2.4	1.6
Length without tail	0.7	1.5	2.4	1.6	0.4	1.4	-1.3	-1.1
Liver weight, left	0.4	0.7	2.2	-1.5	0.1	0.8	-0.0	-0.7
Liver weight, right	2.0	3.4	5.1	-2.2	-1.9	0.7	-2.2	1.6
Parametrial fat weight	1.6	3.1	11.2	-3.3	-1.0	-0.8	-0.6	1.6
Retroperitoneal fat weight	1.5	5.0	9.8	-2.1	-1.7	2.8	-3.1	-0.2
Intraocular pressure	1.7	2.4	4.2	-2.0	-1.5	0.4	-1.9	1.3
Extensor digitorum longus weight	0.2	0.8	2.1	0.2	-0.9	1.4	-0.9	-0.3
Soleus weight	0.2	0.4	1.1	-0.0	0.7	0.8	-0.2	-1.0
Tibialis anterior weight	0.4	1.5	4.9	2.2	0.5	-0.0	1.3	-0.7
Tibia length	0.2	0.5	1.9	-1.4	0.2	0.5	-0.6	-0.4
Number of licking bursts	0.6	0.7	2.1	0.0	-0.8	-0.7	-0.4	1.5
Food consumed during 24 hour testing period	2.2	2.7	6.2	0.1	-1.0	2.5	-2.3	-1.0
Times rat made contact with spout	0.8	1.0	2.3	0.2	-1.5	0.7	-1.1	0.9
Mean time between licks in bursts	0.5	0.6	1.3	0.6	-0.5	-1.0	0.5	1.2
Mean num. licks in bursts	0.5	0.6	1.6	-0.0	0.0	1.3	-0.5	-1.2
Std. dev. time between licks in bursts	0.5	0.6	1.2	-0.3	1.1	-0.0	0.8	-1.0
Water consumed over 24 hours	1.2	1.4	3.3	0.7	-0.9	1.8	-1.5	-0.7
Indifference point 0 sec	0.3	0.4	1.8	-1.4	0.4	-0.2	-0.1	0.2
Indifference point AUC	0.5	0.6	2.8	-1.7	0.3	-0.3	0.1	0.1
Indifference point function ln k	1.2	1.8	3.2	0.4	-1.5	1.8	-1.8	-0.1
Indifference point function log k	1.2	1.8	3.2	0.4	-1.5	1.8	-1.8	-0.1
Delay discounting total patch changes 0 sec	0.2	0.4	1.4	-1.2	0.5	-0.5	0.2	0.3
Delay discounting total patch changes 12 sec	0.4	0.6	2.5	-1.6	0.4	0.2	0.1	-0.4
Delay discounting total patch changes 18 sec	0.8	1.1	3.6	-1.9	0.1	-1.0	0.1	1.0
Delay discounting total patch changes 24 sec	0.1	0.1	0.4	-0.7	-0.1	-0.2	-0.0	0.5
Delay discounting total patch changes 6 sec	0.6	0.9	2.7	-1.6	1.0	-0.5	0.6	-0.0
Delay discounting time to switch 0 sec	0.3	0.4	1.0	1.0	0.4	-0.3	0.9	-0.4
Delay discounting water rate 0 sec	0.3	0.5	1.3	-1.1	0.1	0.9	-0.5	-0.5
Delay discounting water rate 12 sec	1.5	2.3	7.8	-2.8	-0.9	0.4	-1.4	1.0
Delay discounting water rate 18 sec	0.2	0.3	0.6	-0.8	-0.4	0.2	-0.7	0.4
Delay discounting water rate 24 sec	0.1	0.2	0.4	-0.2	0.3	0.6	-0.4	-0.6
Delay discounting water rate 6 sec	1.0	1.4	3.0	-1.7	-0.8	-0.5	-1.0	1.4
Locomotor activity	2.4	3.8	9.0	-0.5	-2.0	2.3	-3.0	0.6
Locomotor testing distance	0.6	0.9	1.8	0.0	-1.2	0.9	-1.4	0.7
Locomotor testing rearing	0.9	1.5	3.6	-0.4	-1.9	1.2	-1.3	0.6
Light reinforcement 1	1.0	1.8	3.3	-0.6	-1.8	1.3	-1.6	1.0
Light reinforcement 2	1.9	2.6	4.9	-1.3	-1.1	2.2	-2.2	-0.4
Reaction time number correct	0.5	0.7	2.6	-1.6	-0.2	-0.7	0.1	0.8
Reaction time mean minus median	0.2	0.3	0.7	-0.8	-0.1	-0.6	-0.1	0.6
Reaction time mean minus median AUC	0.5	0.7	2.5	-1.6	-0.5	-0.3	-0.3	0.7
Reaction time num false alarms	0.9	1.2	2.2	-0.4	-1.5	-0.3	-1.2	1.5
Reaction time num false alarms AUC	1.1	1.5	2.9	0.2	-1.7	-0.4	-1.4	1.7
Reaction time trials correct on left	0.5	0.7	2.6	-1.6	-0.2	-0.7	0.1	0.8
Reaction time trials on left	0.5	0.7	2.4	-1.5	-0.2	-0.7	0.2	0.8
Reaction time mean	1.6	2.2	3.9	1.0	1.9	-1.6	2.0	-0.4
Reaction time mean AUC	1.7	2.2	4.1	1.0	1.7	-1.7	2.0	-0.3
Median of all reaction times	2.5	3.4	5.9	1.5	2.4	-1.7	2.4	-0.7
Reaction time omissions	1.0	1.4	2.1	1.4	1.2	-1.3	1.3	-0.2
Reaction time false alarm rate	0.7	1.0	1.7	0.8	-1.3	0.0	-1.3	1.0
Reaction time premature initiation rate	1.5	2.0	5.1	0.8	1.8	0.7	0.8	-2.3
Reaction time premature initiations	0.8	1.1	2.6	-0.1	1.5	0.2	0.8	-1.6
Std. dev. reaction times	0.4	0.5	1.4	0.3	0.6	-1.2	0.7	0.4
Reaction time trials completed	0.5	0.7	2.4	-1.5	-0.2	-0.7	0.2	0.8
Reaction time trials AUC	0.5	0.8	3.3	-1.8	-0.2	-0.4	-0.0	0.6
Social response proportion	0.7	0.8	1.7	0.3	-0.7	1.3	-1.1	-0.5
Social responses	1.8	2.3	4.0	-1.2	-1.9	1.5	-2.0	0.6
Social time	0.7	0.9	2.5	-0.1	-1.1	-0.5	-0.7	1.6
Conditioned locomotion	0.0	0.0	0.1	0.2	-0.2	0.3	-0.0	0.0
Cocaine response after cond. corrected	1.1	1.2	3.8	-1.9	-0.6	0.4	-1.0	0.8
Cocaine response after cond. not corrected	1.8	2.0	5.9	-2.4	-1.1	0.1	-1.1	1.4
Cocaine response before conditioning	0.3	0.4	0.7	-0.7	-0.5	-0.7	0.1	0.9
Saline control response	0.0	0.1	0.2	-0.3	-0.0	0.2	-0.4	-0.0
Condit. Reinf. active minus inactive responses	0.5	0.6	2.1	-1.4	0.3	0.5	-0.4	-0.7
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.2	0.1	0.1	-0.1	-0.4
Condit. Reinf. active responses	1.1	1.6	3.9	-2.0	0.1	1.4	-0.8	-1.2
Condit. Reinf. inactive responses	2.1	2.6	6.4	-2.5	-0.4	2.0	-1.2	-1.1
Condit. Reinf. lever presses	0.4	0.5	1.4	-0.7	-0.3	1.2	-0.4	-0.8
Condit. Reinf. lever reinforcers received	0.9	1.3	3.7	-1.9	0.2	1.1	-0.7	-1.0
Pavlov. Cond. lever latency	0.2	0.3	0.8	0.9	0.1	-0.5	0.2	0.4
Pavlov. Cond. magazine entry latency	2.6	3.0	5.6	0.9	2.4	-1.1	2.2	-1.7
Pavlov. Cond. change in total contacts	1.0	1.4	3.2	-0.9	1.5	0.2	0.7	-1.8
Pavlov. Cond. index score	0.6	0.8	1.6	-0.1	1.3	-0.2	1.0	-1.2
Pavlov. Cond. latency score	0.8	1.1	2.2	-0.1	1.4	-0.1	1.0	-1.5
Pavlov. Cond. lever contacts	0.4	0.5	1.5	-0.4	0.6	0.7	0.1	-1.2
Pavlov. Cond. magazine entry number	1.2	1.5	2.3	-1.1	-1.5	0.6	-1.5	1.3
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.5	-0.6	0.7	0.8	-0.2	-1.2
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	1.3	-0.1	1.1	-0.3	1.0	-1.0
Pavlov. Cond. response bias	0.5	0.6	1.7	0.0	1.0	0.2	0.6	-1.3
Conditioned reinforcement - actives	0.8	0.8	1.5	0.3	-1.0	-0.5	-1.0	1.2
Conditioned reinforcement - inactives	0.1	0.2	0.4	-0.2	-0.5	0.3	-0.6	0.1
Conditioned locomotion	1.6	1.9	3.8	-1.5	-1.2	1.4	-1.9	0.2
Intermittent access intake day 1-15 change	0.1	0.1	0.1	0.4	-0.3	-0.2	-0.4	0.1
Intermittent access intake escalation	0.2	0.2	0.5	0.6	-0.5	0.2	-0.7	0.1
Intermittent access intake escalation 2	0.3	0.3	0.8	-0.9	0.6	-0.4	0.4	-0.4
Intermitt. access day 1 inactive lever presses	2.3	2.5	7.1	-2.7	1.3	0.7	0.7	-1.6
Intermitt. access day 15 inactive lever presses	1.5	1.7	4.0	-0.7	0.9	1.6	-0.6	-2.0
Intermitt. access escalation Index	1.2	1.1	4.8	2.2	-0.1	0.6	-0.4	-0.3
Intermittent access day 1 total infusions	1.8	2.0	5.7	-0.1	-1.6	1.2	-2.4	0.7
Intermittent access day 15 total infusions	1.4	1.6	4.2	0.9	-1.4	1.0	-2.1	0.4
Intermittent access terminal intake (last 3 days)	1.9	2.1	6.1	-0.5	-1.3	1.5	-2.5	0.0
Intermittent access total infusions	1.8	2.0	5.9	0.1	-1.4	1.5	-2.4	0.2
Intermittent access day 1 locomotion	1.8	1.8	4.8	1.0	-1.4	0.4	-2.2	1.1
Intermittent access day 15 total locomotion	2.4	2.6	6.1	1.4	-1.8	0.9	-2.5	0.9
Intermittent access total locomotion	1.2	1.3	4.1	-0.0	-1.2	1.0	-2.0	0.4
Intermittent access standard deviation	0.3	0.3	0.8	-0.7	0.5	0.4	-0.1	-0.9
Cocaine induced anxiety	2.1	2.4	4.6	-1.7	1.2	1.7	0.0	-2.1
Post-drug Anxiety	3.3	3.6	8.4	-0.8	2.4	1.4	1.2	-2.9
Baseline Anxiety	1.9	2.0	6.9	2.6	0.4	-1.2	1.1	0.4
Lifetime Intake	2.2	2.5	6.7	-0.4	-1.7	1.6	-2.6	0.3
Incentive Sensitization - Responses	0.9	0.9	1.9	-0.8	1.4	0.3	0.1	-1.3
Incentive Sensitization - Breakpoint	0.9	0.9	1.8	-1.0	1.3	0.4	0.0	-1.3
Progressive ratio test 1 active lever presses	2.2	2.3	5.7	-0.3	-1.7	0.6	-2.4	1.5
Progressive ratio test 1 breakpoint	2.1	2.2	5.4	-0.6	-1.7	0.5	-2.3	1.5
Progressive ratio test 1 inactive lever presses	0.4	0.4	0.9	-0.1	-0.7	0.6	-0.9	0.4
Progressive ratio test 2 active lever presses	0.3	0.3	0.7	-0.8	0.6	0.1	-0.7	-0.4
Progressive ratio test 2 breakpoint	0.3	0.3	0.8	-0.9	0.6	0.1	-0.5	-0.4
Progressive ratio test 2 inactive lever presses	0.4	0.4	0.8	0.1	0.4	0.8	-0.9	-0.8
Total sessions with >9 infusions	3.4	3.8	7.6	-1.1	-2.6	1.5	-2.8	1.0
Short access day 1 total inactive lever presses	1.5	1.7	4.2	-0.2	-1.1	2.0	-1.6	-0.6
Short access day 10 total inactive lever presses	2.8	3.1	12.6	-3.6	0.7	0.9	-0.1	-1.2
Short access day 1 total infusions	2.5	2.6	5.4	-0.1	-2.3	1.3	-2.3	0.7
Short access day 10 total infusions	2.7	3.0	7.7	-1.1	-1.7	1.7	-2.8	0.6
Short access total infusions	3.2	3.5	8.1	-0.9	-1.9	2.2	-2.9	0.0
Short access day 1 locomotion	0.1	0.1	0.3	0.0	-0.5	0.3	-0.5	0.1
Short access day 10 total locomotion	2.0	2.2	4.1	0.6	-2.0	0.1	-1.6	1.9
Short access total locomotion	1.2	1.2	2.8	-0.3	-1.2	1.2	-1.7	0.2
Compulsive drug intake	1.5	1.5	3.6	1.0	1.3	-0.5	1.9	-1.1
One hour access (0.3 mA shock)	0.6	0.7	1.4	-1.0	-0.8	0.6	-1.2	0.1
One hour access (shock baseline)	1.9	2.2	5.7	-1.2	-1.6	1.0	-2.4	0.8
Number of responses in last shaping day	0.4	0.4	1.4	1.2	-0.5	0.3	-0.5	0.0
Context. condit. distance diff. score	1.7	2.1	7.7	2.8	-0.7	1.3	-0.5	-0.5
Locomotion velocity, session 1	2.9	3.1	6.9	-2.6	-2.0	0.9	-1.7	1.1
Locomotion distance, session 1	0.6	0.8	1.8	-0.9	-1.1	-0.5	-0.2	1.3
Locomotion velocity, session 2	4.6	5.4	13.0	-3.6	-1.9	1.8	-2.6	0.8
Locomotion distance, session 2	0.4	0.6	1.5	-1.2	0.7	-0.4	0.7	-0.4
Locomotion velocity, session 3	4.3	5.0	9.9	-1.6	-3.1	1.1	-2.5	2.1
Locomotion distance, session 3	1.5	1.7	3.2	-1.1	-1.6	-0.2	-1.2	1.8
Stereotopy head waving bouts, day 3	0.5	0.6	1.3	0.5	-1.0	1.1	-0.7	-0.1
Stereotopy head waving duration, day 3	1.1	1.4	3.5	0.8	-1.4	1.9	-0.9	-0.4
Locomotion velocity, session 7	1.4	1.5	3.1	-0.6	-1.8	1.2	-1.5	0.8
Locomotion distance, session 7	0.3	0.4	0.7	-0.4	-0.6	0.2	-0.8	0.8
Stereotopy head waving bouts, day 7	0.8	1.0	1.9	0.5	-1.4	1.3	-1.0	0.1
Stereotopy head waving duration, day 7	0.5	0.6	1.1	0.8	-1.1	0.8	-0.6	0.2
Locomotion velocity, session 8	2.0	2.4	6.4	-0.6	-0.9	2.5	-1.8	-1.0
Locomotion distance, session 8	0.3	0.5	0.9	0.9	-0.7	0.8	-0.8	0.1
Degree of sensitization distance	0.7	0.7	1.9	0.1	0.9	0.9	-0.1	-1.4
Degree of sensitization stereotypy	0.4	0.5	1.0	0.4	-1.0	0.8	-0.7	0.0
Condit. Reinf. active minus inactive responses	0.2	0.2	0.6	-0.4	0.5	-0.8	-0.2	0.2
Condit. Reinf. active-inactive response ratio	0.9	1.0	2.2	1.5	0.8	-1.3	0.6	0.2
Condit. Reinf. active responses	0.7	0.9	1.6	-1.3	-0.1	-1.2	-0.2	1.2
Condit. Reinf. inactive responses	1.3	1.6	4.6	-2.2	-0.9	-0.6	-0.4	1.4
Incentive salience index mean	0.9	1.0	2.1	-1.5	-0.6	-0.1	-1.4	0.9
Condit. Reinf. lever presses	2.5	3.3	5.5	-2.3	-1.8	0.9	-2.3	1.4
Time in familiar zone, hab. session 1	1.1	1.0	2.8	-1.7	-0.6	1.2	-0.7	-0.3
Time in novel zone, hab. session 1	1.4	1.3	6.3	2.5	0.2	-0.2	0.3	-0.2
Total zone transitions, hab. session 1	1.4	2.0	4.4	2.1	0.7	-1.6	1.6	0.4
Total locomotion distance, hab. session 1	0.3	0.4	0.8	0.9	-0.6	-0.1	-0.2	0.8
Locomotion velocity, hab. session 1	0.2	0.4	1.0	0.2	-0.8	-0.1	-0.4	1.0
Time in familiar zone, hab. session 2	0.6	0.6	1.0	0.6	-1.0	0.2	-0.8	0.9
Time in novel zone, hab. session 2	0.5	0.5	1.0	0.3	0.9	-0.7	1.0	-0.5
Total zone transitions, hab. session 2	0.4	0.5	1.3	0.3	0.7	0.5	0.5	-1.2
Total locomotion distance, hab. session 2	0.0	0.1	0.1	0.2	0.1	0.4	-0.1	-0.3
Locomotion velocity, hab. session 2	0.0	0.0	0.1	-0.0	0.1	0.3	-0.2	-0.2
Novel to familiar place preference ratio	0.5	0.5	1.4	1.2	-0.7	-0.2	0.6	0.4
Novelty place preference	0.6	0.6	1.4	1.2	-1.1	0.1	0.3	0.6
Time in novel zone, NPP test	0.8	0.8	2.0	1.4	-1.2	0.1	0.4	0.6
Total zone transitions, NPP test	0.6	0.8	1.9	-0.1	0.7	-1.3	1.4	0.1
Total locomotion distance, NPP test	0.2	0.3	1.0	-1.0	0.2	-0.6	0.4	0.3
Locomotion velocity, NPP test	0.3	0.4	1.3	-1.2	0.2	-0.7	0.3	0.4
Pavlov. Cond. lever latency	1.6	2.1	4.2	2.0	1.3	-0.5	1.7	-1.1
Pavlov. Cond. magazine entry latency	0.5	0.6	2.5	-1.6	0.4	-0.5	-0.2	0.1
Pavlov. Cond. change in total contacts	0.5	0.6	1.8	-1.3	0.6	0.1	-0.8	-0.2
Pavlov. Cond. index score	0.9	1.1	4.6	-2.2	-0.1	0.1	-0.9	0.3
Pavlov. Cond. latency score	0.8	1.0	3.4	-1.8	-0.4	0.3	-1.1	0.3
Pavlov. Cond. lever contacts	2.6	3.1	5.8	-2.4	-1.5	0.7	-2.3	1.3
Pavlov. Cond. magazine entry number	0.5	0.7	2.8	1.7	-0.4	0.4	0.4	-0.1
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.5	0.3	0.9	-1.2	0.6	0.4
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.3	5.0	-2.2	-0.2	-0.1	-0.9	0.6
Pavlov. Cond. response bias	1.8	2.2	7.9	-2.8	-0.5	0.1	-1.5	0.9
Bone: apparent density	0.4	0.7	1.3	0.9	0.5	-1.1	1.1	0.3
Bone surface	0.2	0.3	0.7	0.9	-0.0	-0.5	0.5	0.4
Bone volume	0.2	0.4	0.6	0.7	-0.0	-0.8	0.7	0.5
Bone: connectivity density	0.2	0.3	0.9	0.0	-0.2	-0.9	0.4	0.7
Bone: cortical apparent density	1.0	1.3	2.2	1.5	1.1	-1.3	1.3	-0.1
Bone: cortical area	0.7	1.1	2.9	0.5	0.1	1.7	-0.9	-1.3
Bone: cortical porosity	0.7	0.8	1.5	-0.4	0.5	1.2	-0.9	-1.1
Bone: cortical porosity	0.7	0.7	1.3	-0.4	0.5	1.2	-0.8	-1.1
Bone: cortical thickness	0.6	1.0	1.7	1.3	1.2	0.2	0.5	-1.2
Bone: cortical thickness	1.4	1.7	3.8	1.3	0.9	1.5	-0.3	-2.0
Bone: cortical tissue density	0.9	1.1	2.1	1.4	1.0	-1.1	1.1	-0.1
Bone: elastic displacement	1.2	1.4	3.7	-1.9	-0.9	0.6	-1.2	0.8
Bone: elastic work	1.6	2.0	5.2	-1.1	-0.5	2.3	-1.4	-1.2
Bone: endosteal estimation	1.0	2.3	5.7	-0.7	-1.3	2.4	-1.7	-0.6
Bone: endosteal perimeter	1.8	3.7	7.8	-1.2	-1.6	2.8	-2.6	-0.5
Bone: final force	1.4	2.4	5.9	1.2	1.3	1.5	0.5	-2.4
Bone: final moment	1.8	2.9	7.3	1.3	1.4	1.8	0.5	-2.7
Bone: marrow area	1.0	2.2	5.7	-0.7	-1.2	2.4	-1.7	-0.7
Bone: maximum diameter	2.7	4.9	13.1	-0.7	-1.1	3.6	-2.6	-1.6
Bone: maximum force	1.7	2.9	7.9	1.0	1.4	1.8	0.5	-2.8
Bone: maximum moment	2.0	3.5	9.3	1.1	1.5	2.1	0.5	-3.1
Bone: minimum diameter	1.1	2.0	3.7	-0.9	-1.4	1.8	-1.9	0.0
Bone: periosteal estimation	1.1	2.3	6.8	-0.1	-0.8	2.6	-1.6	-1.2
Bone: periosteal perimeter	2.4	4.0	8.4	-1.0	-1.6	2.9	-2.9	-0.5
Bone: post-yield work	1.1	1.5	2.3	1.2	1.4	-0.4	1.5	-1.2
Bone: stiffness	3.6	5.8	10.2	2.2	2.9	0.2	2.3	-3.2
Bone: tissue strength	1.6	1.5	3.1	0.3	1.8	-0.2	1.4	-1.5
Bone: trabecular number	0.4	0.7	1.7	-0.1	-0.4	-1.2	0.3	1.3
Bone: trabecular spacing	1.6	2.1	5.1	-1.3	-0.6	2.2	-1.5	-1.2
Bone: trabecular thickness	0.4	0.5	1.6	1.2	-0.0	-0.6	0.1	0.6
Bone: trabecular tissue density	1.5	2.2	3.7	1.6	1.5	-1.3	1.9	-0.7
Breakpoint value in progressive ratio session	0.9	1.0	1.8	-0.6	1.3	-0.1	1.1	-1.2
Distance traveled before self-admin	0.4	0.4	1.0	-0.4	-1.0	0.3	-0.7	0.5
Distance traveled after self-admin	0.4	0.5	1.1	-0.7	-0.2	1.1	-0.4	-0.7
Delta time in closed arm before/after self-admin	0.4	0.4	0.5	0.7	0.7	0.2	0.6	-0.6
Delta time in open arm before/after self-admin	1.2	1.2	3.1	-0.0	-1.8	-0.2	-0.8	1.4
Diff in mean of infusions in LGA sessions	1.1	1.2	3.5	-0.3	1.9	0.3	0.5	-1.5
Extinction: sum of active levers before priming	0.6	0.7	1.4	0.1	1.2	-0.5	1.1	-0.7
Active lever presses in extinction session 6	1.5	1.4	2.8	-1.3	1.1	1.1	-0.0	-1.7
Delta distance traveled before/after self-admin	0.3	0.3	0.6	-0.3	-0.6	0.8	-0.6	-0.1
Delta ambulatory time before/after self-admin	0.2	0.2	0.6	0.5	-0.1	0.8	-0.4	-0.4
Time in closed arm before self-admin	0.7	0.8	1.8	0.4	1.4	-0.9	0.9	-0.5
Time in closed arm after self-admin	0.7	0.7	3.6	1.9	0.2	0.0	-0.0	-0.2
Time in open arm before self-admin	0.6	0.6	1.2	-1.1	-1.0	-0.2	-0.3	0.9
Time in open arm after self-admin	0.5	0.6	2.4	-1.6	-0.5	-0.1	0.2	0.5
Sum of active levers in priming session hrs 5-6	0.9	0.8	1.3	-1.0	1.1	0.0	0.7	-1.2
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	0.5	-0.5	-0.2	-0.4	0.6
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.7	-0.5	-0.7	0.1	-0.8	0.3
Time to tail flick, test, before self-admin	1.9	1.9	4.2	0.1	-1.9	1.0	-2.0	0.7
Time to tail flick, test, after self-admin	1.2	1.3	4.3	2.1	1.1	-0.4	0.6	-0.5
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.2	-1.0	0.6	0.6	0.1	-1.1
Delta time to tail flick, test, before/after SA	3.2	2.8	5.6	1.3	2.4	-1.4	2.1	-0.8
Ambulatory time before self-admin	0.4	0.4	1.1	-0.5	-1.0	0.1	-0.5	0.6
Ambulatory time after self-admin	0.1	0.1	0.2	0.2	0.0	0.4	0.1	-0.5
Total heroin consumption	1.5	1.7	3.1	-1.3	1.7	0.8	0.7	-1.8
Area under the delay curve	2.4	2.6	4.5	-1.5	1.4	-2.1	2.0	0.4
Delay disc. indifference point, 0s delay	0.4	0.4	2.0	-1.4	0.1	0.3	-0.2	-0.1
Delay disc. indifference point, 16s delay	2.4	2.4	5.0	-0.4	1.3	-2.2	2.2	0.4
Delay disc. indifference point, 2s delay	0.6	0.7	1.0	-1.0	1.0	-0.7	0.9	-0.3
Delay disc. indifference point, 24s delay	1.2	1.2	4.0	-2.0	1.2	0.1	0.4	-0.7
Delay disc. indifference point, 4s delay	2.8	3.0	5.9	-1.4	1.5	-2.1	2.4	0.0
Delay disc. indifference point, 8s delay	2.1	2.2	4.8	-0.2	1.4	-2.0	2.2	0.2
Delay discount exponential model param	2.7	2.8	4.8	1.8	-1.4	2.2	-2.0	-0.4
Delay discount hyperbolic model param	2.5	2.7	4.3	1.9	-1.3	2.1	-1.9	-0.4
Fecal boli incidents, locomotor time 1	0.2	0.2	0.8	-0.9	-0.1	0.3	-0.2	0.0
Change in fecal boli incidents, locomotor task	0.3	0.3	0.9	-0.4	-0.6	-0.3	-0.1	0.9
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.6	-0.1	-0.0	0.8	0.2	-0.5
Bouts of movement, locomotor time 1	0.2	0.2	0.4	0.1	0.2	0.6	-0.5	-0.6
Total resting periods, locomotor time 1	0.4	0.5	1.2	0.2	0.9	0.4	0.3	-1.1
Rest time, locomotor task time 1	0.6	0.6	1.9	-1.4	-0.3	0.8	-0.4	-0.4
Distance moved, locomotor task time 1	0.1	0.1	0.2	-0.3	0.0	0.4	-0.4	-0.2
Vertical activity count, locomotor time 1	0.2	0.2	0.4	0.3	0.6	0.2	0.4	-0.5
Time >=10cm from walls, locomotor time 2	0.4	0.4	1.1	-0.3	0.6	1.0	0.1	-0.8
Bouts of movement, locomotor time 2	1.6	1.7	3.3	1.0	1.8	-0.7	1.6	-1.1
Total resting periods, locomotor time 2	1.5	1.6	3.1	0.7	1.8	-0.9	1.6	-1.0
Rest time, locomotor task time 2	2.1	2.5	5.1	-1.5	-1.1	-1.9	-0.1	2.3
Distance moved, locomotor task time 2	1.3	1.5	4.8	-0.1	-0.3	2.2	-1.0	-1.2
Vertical activity count, locomotor time 2	1.6	1.8	5.5	-0.5	0.0	2.3	-0.9	-1.6
Weight adjusted by age	1.2	1.3	4.1	-0.6	-0.7	2.0	-1.0	-0.8
Seeking ratio, delayed vs. immediate footshock	0.8	0.9	1.8	0.7	1.0	-1.0	1.3	-0.1
Locomotion in novel chamber	2.0	2.5	5.6	-0.1	-2.4	-0.3	-1.4	2.2
Locomotion in novel chamber post-restriction	0.3	0.3	0.8	0.9	0.2	0.4	0.6	-0.4
Progressive ratio	0.5	0.6	2.0	-1.4	-0.1	-0.8	0.1	0.7
Food seeking constrained by brief footshock	0.3	0.4	1.5	0.3	0.1	1.2	-0.4	-0.6
Seeking ratio, punishment vs. effort	1.5	1.9	3.3	1.8	0.9	1.4	0.4	-1.7
Run reversals in cocaine runway, females	1.1	1.1	1.8	1.1	-1.2	-0.6	-0.7	1.4
Run reversals in cocaine runway, males	2.2	2.1	3.7	-1.1	-1.9	0.2	-1.9	1.5
Latency to leave start box in cocaine runway	0.9	1.0	2.6	-0.1	-0.6	1.6	-1.3	-0.5
Latency to leave start box in cocaine runway, F	0.7	0.8	1.6	0.9	-0.6	1.3	-0.9	-0.3
Latency to leave start box in cocaine runway, M	1.1	1.1	2.0	-1.4	-0.3	1.2	-1.2	-0.6
Cd content in liver	0.3	0.3	0.8	0.3	0.9	-0.6	0.6	-0.3
Co content in liver	0.8	0.9	1.7	-0.9	-1.0	0.9	-1.3	0.4
Cu content in liver	3.7	4.5	8.5	1.6	1.8	-2.8	2.9	0.4
Fe content in liver	0.2	0.2	0.7	-0.8	0.1	0.5	-0.4	-0.3
K content in liver	0.9	0.9	2.2	0.7	1.5	-0.0	0.6	-1.3
Mg content in liver	1.1	1.1	3.0	0.6	1.7	-0.3	0.8	-1.2
Mn content in liver	1.1	1.2	2.9	-0.3	-1.2	1.1	-1.7	0.6
Na content in liver	2.1	2.2	3.2	1.5	1.7	-1.8	1.7	-0.2
Rb content in liver	1.6	2.0	4.5	2.1	1.4	-0.5	1.4	-1.1
Se content in liver	0.2	0.3	0.5	-0.7	-0.4	-0.3	-0.5	0.7
Sr content in liver	1.4	1.3	2.8	-1.0	-1.2	-1.1	-0.2	1.7
Zn content in liver	0.4	0.5	1.0	-0.0	-0.3	-1.0	0.6	1.0