Hub : Genes

Npr2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000015991	0.04	0.06	6.7e-03	0.01	0.01	0.01	0.01	3.0e-02	2.3e-02	4.6e-02	2.6e-02
2	Brain	gene expression	ENSRNOG00000015991	0.08	0.05	5.7e-05	0.06	0.05	0.05	0.05	6.1e-06	1.6e-05	2.7e-05	2.4e-05
3	Liver	gene expression	ENSRNOG00000015991	0.06	0.05	7.4e-04	0.01	0.03	0.03	0.02	4.0e-02	4.8e-04	6.4e-04	1.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
BMI with tail	2.1	6.8	9.0	-3.0	2.7	-2.0
BMI without tail	5.1	10.7	15.2	-3.8	3.9	-1.6
Body weight	3.0	12.5	17.8	-4.2	4.1	-1.6
Epididymis fat weight	0.5	1.1	2.0	-1.1	1.4	-0.3
Glucose	1.0	1.6	2.3	-1.5	1.5	-0.4
Heart weight	0.6	0.9	1.6	-1.1	1.3	-0.1
Left kidney weight	0.5	1.4	2.3	-1.2	1.5	0.5
Right kidney weight	0.0	0.1	0.2	-0.1	0.4	0.4
Tail length	2.3	6.9	10.5	-3.0	3.2	-1.1
Length with tail	0.7	2.6	4.3	-1.9	2.1	0.0
Length without tail	0.4	0.9	1.0	0.9	-0.9	1.0
Liver weight, left	0.5	0.8	1.2	-0.7	1.1	-0.8
Liver weight, right	0.0	0.1	0.1	0.3	-0.1	0.3
Parametrial fat weight	0.2	0.4	0.9	-0.5	1.0	0.2
Retroperitoneal fat weight	0.1	0.3	0.4	0.6	-0.6	-0.3
Intraocular pressure	1.9	2.7	4.2	-2.0	2.0	0.1
Extensor digitorum longus weight	4.0	16.1	22.6	-4.7	4.8	-1.8
Soleus weight	0.6	1.6	4.6	0.3	0.5	2.1
Tibialis anterior weight	6.0	20.7	32.5	-5.3	5.7	-1.4
Tibia length	0.2	0.5	1.1	0.2	0.5	1.1
Number of licking bursts	4.3	5.0	6.2	-2.5	2.4	-1.7
Food consumed during 24 hour testing period	0.7	0.9	1.6	-1.0	1.3	-0.2
Times rat made contact with spout	0.3	0.4	0.5	-0.6	0.5	-0.7
Mean time between licks in bursts	0.4	0.5	0.9	0.9	-0.7	-0.3
Mean num. licks in bursts	2.0	2.4	3.2	1.8	-1.8	0.9
Std. dev. time between licks in bursts	0.3	0.4	0.5	0.7	-0.7	0.0
Water consumed over 24 hours	0.7	0.8	1.0	-1.0	1.0	-0.5
Indifference point 0 sec	1.5	2.5	5.9	-0.8	1.0	2.4
Indifference point AUC	7.4	8.7	12.1	-3.5	3.5	-1.4
Indifference point function ln k	2.5	3.6	4.8	2.1	-2.2	1.2
Indifference point function log k	2.5	3.6	4.8	2.1	-2.2	1.2
Delay discounting total patch changes 0 sec	1.5	2.5	4.4	-1.2	1.3	2.1
Delay discounting total patch changes 12 sec	1.9	2.5	4.0	-2.0	1.9	-0.4
Delay discounting total patch changes 18 sec	0.7	0.9	1.6	-1.1	1.2	0.0
Delay discounting total patch changes 24 sec	2.4	3.0	4.5	-2.1	2.1	0.2
Delay discounting total patch changes 6 sec	2.6	3.9	5.6	-2.4	2.4	0.8
Delay discounting time to switch 0 sec	2.7	4.2	6.7	2.4	-2.6	-0.0
Delay discounting water rate 0 sec	1.9	3.1	4.7	-1.9	2.2	0.9
Delay discounting water rate 12 sec	0.2	0.3	0.6	-0.1	0.5	0.8
Delay discounting water rate 18 sec	0.3	0.4	0.6	-0.8	0.7	-0.3
Delay discounting water rate 24 sec	0.2	0.2	0.6	-0.1	-0.1	-0.8
Delay discounting water rate 6 sec	0.6	0.8	1.6	-0.9	1.3	-0.1
Locomotor activity	0.0	0.0	0.0	-0.1	0.2	-0.1
Locomotor testing distance	0.2	0.3	0.8	0.2	0.1	0.9
Locomotor testing rearing	0.5	0.8	1.6	-1.0	1.3	-0.1
Light reinforcement 1	1.4	2.6	3.7	-1.1	1.9	1.8
Light reinforcement 2	1.9	2.4	6.0	-0.4	1.1	2.5
Reaction time number correct	0.2	0.2	0.3	-0.4	0.5	0.6
Reaction time mean minus median	2.1	2.7	7.5	-0.7	0.2	-2.7
Reaction time mean minus median AUC	2.1	2.7	5.9	-1.2	0.8	-2.4
Reaction time num false alarms	0.2	0.3	0.8	-0.1	-0.1	-0.9
Reaction time num false alarms AUC	0.3	0.4	0.5	-0.7	0.6	-0.6
Reaction time trials correct on left	0.2	0.2	0.3	-0.4	0.5	0.6
Reaction time trials on left	0.1	0.2	0.4	-0.3	0.4	0.6
Reaction time mean	1.6	2.2	2.5	1.3	-1.6	-1.5
Reaction time mean AUC	1.8	2.4	2.9	1.4	-1.7	-1.5
Median of all reaction times	2.3	3.1	4.7	2.1	-2.2	-0.5
Reaction time omissions	1.2	1.6	2.6	1.5	-1.6	0.1
Reaction time false alarm rate	0.2	0.2	0.5	0.1	-0.4	-0.7
Reaction time premature initiation rate	2.0	2.7	4.5	1.9	-2.1	0.2
Reaction time premature initiations	1.2	1.7	2.7	1.5	-1.6	0.5
Std. dev. reaction times	1.4	1.9	5.4	0.2	-0.5	-2.3
Reaction time trials completed	0.1	0.2	0.4	-0.3	0.4	0.6
Reaction time trials AUC	0.1	0.2	0.3	-0.3	0.4	0.5
Social response proportion	2.0	2.2	3.3	1.8	-1.8	-0.5
Social responses	0.6	0.7	0.8	-0.9	0.8	-0.9
Social time	0.1	0.2	0.3	0.5	-0.3	-0.3
Conditioned locomotion	0.6	0.7	2.2	0.1	-0.0	1.5
Cocaine response after cond. corrected	2.5	2.8	4.9	1.5	-1.1	2.2
Cocaine response after cond. not corrected	2.1	2.3	4.5	1.3	-0.8	2.1
Cocaine response before conditioning	0.9	1.1	1.3	-1.0	1.1	-0.9
Saline control response	0.8	1.1	2.0	-1.0	1.4	0.6
Condit. Reinf. active minus inactive responses	0.7	0.9	1.0	-1.0	1.0	-0.7
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	-0.4	0.2	-0.6
Condit. Reinf. active responses	2.2	3.1	4.0	-2.0	2.0	-1.1
Condit. Reinf. inactive responses	3.0	3.8	4.3	-2.0	2.1	-1.7
Condit. Reinf. lever presses	2.6	3.6	4.4	-1.9	1.7	-2.1
Condit. Reinf. lever reinforcers received	2.5	3.6	4.6	-2.1	2.2	-1.3
Pavlov. Cond. lever latency	3.0	4.1	5.0	2.0	-1.8	2.2
Pavlov. Cond. magazine entry latency	0.4	0.5	0.6	0.8	-0.7	-0.5
Pavlov. Cond. change in total contacts	1.7	2.3	5.6	-0.9	0.7	-2.4
Pavlov. Cond. index score	0.7	0.9	2.5	-0.4	0.3	-1.6
Pavlov. Cond. latency score	0.9	1.1	3.0	-0.6	0.4	-1.7
Pavlov. Cond. lever contacts	1.5	2.1	2.6	-1.5	1.3	-1.6
Pavlov. Cond. magazine entry number	0.7	0.9	2.6	0.0	0.1	1.6
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.7	-0.9	0.8	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	2.8	-0.4	0.3	-1.7
Pavlov. Cond. response bias	0.9	1.2	2.3	-0.8	0.7	-1.5
Conditioned reinforcement - actives	0.1	0.1	0.2	-0.5	-0.0	-0.2
Conditioned reinforcement - inactives	0.1	0.1	0.2	0.3	-0.1	0.4
Conditioned locomotion	0.1	0.2	0.4	-0.6	0.3	0.1
Intermittent access intake day 1-15 change	1.1	1.1	2.6	-0.7	0.4	-1.6
Intermittent access intake escalation	1.4	1.4	2.4	-1.1	0.8	-1.5
Intermittent access intake escalation 2	1.8	1.8	3.9	-1.0	0.7	-2.0
Intermitt. access day 1 inactive lever presses	0.5	0.6	0.9	-0.9	0.9	-0.2
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.6	-0.1	0.2	0.8
Intermitt. access escalation Index	1.1	1.0	1.9	-1.0	1.4	0.3
Intermittent access day 1 total infusions	1.1	1.3	3.2	0.5	-0.6	1.8
Intermittent access day 15 total infusions	0.3	0.3	0.7	-0.8	0.5	-0.1
Intermittent access terminal intake (last 3 days)	0.4	0.4	0.8	-0.9	0.7	0.0
Intermittent access total infusions	0.6	0.6	1.0	-1.0	0.8	0.4
Intermittent access day 1 locomotion	1.4	1.4	2.6	0.8	-1.0	1.6
Intermittent access day 15 total locomotion	0.9	0.9	1.2	0.8	-1.0	1.1
Intermittent access total locomotion	0.5	0.6	1.2	0.6	-1.1	0.5
Intermittent access standard deviation	0.3	0.3	0.4	-0.6	0.4	-0.6
Cocaine induced anxiety	1.1	1.2	1.8	1.3	-1.1	0.8
Post-drug Anxiety	0.3	0.4	0.8	-0.5	0.9	-0.3
Baseline Anxiety	2.0	2.1	2.8	-1.4	1.2	-1.7
Lifetime Intake	0.9	1.0	1.2	-0.9	1.0	1.1
Incentive Sensitization - Responses	0.3	0.3	0.7	0.2	0.0	0.9
Incentive Sensitization - Breakpoint	0.3	0.3	0.9	0.3	-0.1	0.9
Progressive ratio test 1 active lever presses	0.9	0.9	2.3	-0.4	0.4	1.5
Progressive ratio test 1 breakpoint	0.8	0.8	1.9	-0.6	0.6	1.4
Progressive ratio test 1 inactive lever presses	1.4	1.5	3.3	-0.5	1.0	1.8
Progressive ratio test 2 active lever presses	0.8	0.9	2.6	0.0	0.1	1.6
Progressive ratio test 2 breakpoint	0.9	1.0	2.8	0.3	-0.1	1.7
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.2	-0.4	0.4	0.4
Total sessions with >9 infusions	1.3	1.4	4.2	0.1	0.3	2.1
Short access day 1 total inactive lever presses	1.3	1.5	2.2	-1.5	1.4	0.5
Short access day 10 total inactive lever presses	0.2	0.2	0.4	-0.4	0.6	-0.3
Short access day 1 total infusions	1.6	1.7	2.5	-1.0	1.3	1.6
Short access day 10 total infusions	1.0	1.1	1.9	-0.7	0.9	1.4
Short access total infusions	1.2	1.3	3.4	-0.3	0.6	1.8
Short access day 1 locomotion	0.5	0.5	1.3	0.4	-0.3	1.1
Short access day 10 total locomotion	0.6	0.7	1.4	0.8	-1.2	-0.2
Short access total locomotion	0.3	0.3	0.8	-0.1	0.2	0.9
Compulsive drug intake	0.2	0.2	0.5	-0.7	0.4	-0.3
One hour access (0.3 mA shock)	0.5	0.6	0.8	-0.9	0.8	0.7
One hour access (shock baseline)	0.7	0.8	1.3	-0.6	0.8	1.1
Number of responses in last shaping day	1.4	1.5	4.0	-0.1	0.6	2.0
Context. condit. distance diff. score	0.1	0.1	0.2	0.3	-0.5	0.0
Locomotion velocity, session 1	2.5	2.7	6.3	-0.6	1.2	2.5
Locomotion distance, session 1	0.6	0.8	1.3	-0.6	0.9	1.1
Locomotion velocity, session 2	2.3	2.7	3.3	-1.8	1.5	-1.5
Locomotion distance, session 2	1.7	2.4	4.3	-1.7	2.1	-0.2
Locomotion velocity, session 3	0.5	0.6	1.5	-0.1	0.5	1.2
Locomotion distance, session 3	2.0	2.2	3.5	-1.7	1.9	0.3
Stereotopy head waving bouts, day 3	0.6	0.7	2.0	0.4	-0.0	1.4
Stereotopy head waving duration, day 3	0.5	0.6	1.1	0.7	-0.5	1.0
Locomotion velocity, session 7	0.0	0.0	0.1	0.3	-0.3	0.1
Locomotion distance, session 7	0.2	0.2	0.4	-0.5	0.6	0.1
Stereotopy head waving bouts, day 7	1.8	2.1	3.2	-1.8	1.8	-0.1
Stereotopy head waving duration, day 7	0.5	0.6	1.1	-0.8	1.0	0.1
Locomotion velocity, session 8	0.2	0.2	0.4	0.0	0.4	0.7
Locomotion distance, session 8	0.2	0.3	0.5	-0.4	0.7	0.6
Degree of sensitization distance	1.0	1.0	1.5	1.2	-1.2	-0.0
Degree of sensitization stereotypy	1.1	1.2	1.8	-1.4	1.3	-0.2
Condit. Reinf. active minus inactive responses	0.6	0.6	0.7	-0.8	0.7	-0.8
Condit. Reinf. active-inactive response ratio	0.4	0.5	0.8	0.9	-0.8	0.0
Condit. Reinf. active responses	2.8	3.4	4.2	-2.0	1.8	-1.7
Condit. Reinf. inactive responses	3.7	4.3	4.7	-2.2	2.0	-2.1
Incentive salience index mean	3.9	4.7	6.5	-2.5	2.4	-1.3
Condit. Reinf. lever presses	8.8	11.9	16.9	-4.1	4.1	-1.4
Time in familiar zone, hab. session 1	1.2	1.1	2.4	0.4	-0.9	-1.5
Time in novel zone, hab. session 1	2.5	2.4	4.8	1.4	-0.8	2.2
Total zone transitions, hab. session 1	0.0	0.0	0.1	-0.1	0.1	-0.3
Total locomotion distance, hab. session 1	0.9	1.2	3.0	-0.7	0.4	-1.7
Locomotion velocity, hab. session 1	1.9	2.7	3.9	-1.6	1.3	-2.0
Time in familiar zone, hab. session 2	0.9	0.9	1.0	0.8	-1.0	-1.0
Time in novel zone, hab. session 2	2.2	2.3	4.7	1.1	-0.9	2.2
Total zone transitions, hab. session 2	0.5	0.6	1.1	-0.8	1.0	0.2
Total locomotion distance, hab. session 2	0.7	0.9	1.2	-1.1	1.0	-0.7
Locomotion velocity, hab. session 2	1.0	1.3	1.7	-1.3	1.2	-0.9
Novel to familiar place preference ratio	3.8	4.0	4.9	2.0	-1.8	2.2
Novelty place preference	4.9	5.1	5.3	2.3	-2.2	2.3
Time in novel zone, NPP test	5.9	6.2	6.7	2.6	-2.4	2.4
Total zone transitions, NPP test	0.6	0.9	1.6	-1.0	1.3	0.3
Total locomotion distance, NPP test	1.5	2.1	3.3	-1.8	1.8	0.0
Locomotion velocity, NPP test	2.0	2.8	4.2	-2.1	2.0	-0.3
Pavlov. Cond. lever latency	6.4	8.2	11.6	3.3	-3.4	1.3
Pavlov. Cond. magazine entry latency	0.5	0.6	0.7	-0.7	0.8	-0.9
Pavlov. Cond. change in total contacts	2.4	2.5	3.7	-1.8	1.9	-0.7
Pavlov. Cond. index score	3.1	3.9	4.8	-2.2	2.2	-1.5
Pavlov. Cond. latency score	2.8	3.5	4.5	-2.1	2.1	-1.3
Pavlov. Cond. lever contacts	4.8	5.7	7.8	-2.8	2.8	-1.2
Pavlov. Cond. magazine entry number	0.8	1.0	1.2	1.0	-1.1	0.9
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.3	-0.6	0.5	-0.5
Pavlov. Cond. lever-magazine prob. diff.	3.0	3.7	4.3	-2.1	2.0	-1.7
Pavlov. Cond. response bias	2.9	3.6	4.7	-2.1	2.2	-1.2
Bone: apparent density	1.1	1.9	2.4	-1.6	1.5	-1.0
Bone surface	0.6	1.1	1.8	-1.2	1.3	-0.1
Bone volume	0.6	1.0	1.6	-1.2	1.3	-0.4
Bone: connectivity density	0.6	0.9	1.2	-1.1	0.9	-0.9
Bone: cortical apparent density	0.5	0.7	1.7	0.3	-0.4	-1.3
Bone: cortical area	2.3	3.5	3.7	-1.9	1.9	-1.8
Bone: cortical porosity	0.4	0.4	0.7	0.7	-0.8	0.3
Bone: cortical porosity	0.0	0.0	0.0	-0.0	-0.1	0.2
Bone: cortical thickness	1.0	1.6	2.6	-1.1	1.0	-1.6
Bone: cortical thickness	0.1	0.1	0.2	0.4	-0.3	-0.4
Bone: cortical tissue density	0.4	0.6	1.4	0.4	-0.5	-1.2
Bone: elastic displacement	3.7	4.2	6.7	2.4	-2.6	0.5
Bone: elastic work	1.9	2.4	3.6	1.5	-1.9	-1.1
Bone: endosteal estimation	0.9	1.8	3.2	-1.5	1.8	-0.2
Bone: endosteal perimeter	0.9	2.0	3.4	-1.6	1.8	0.2
Bone: final force	1.3	2.1	2.8	-1.4	1.7	-1.2
Bone: final moment	1.0	1.7	2.0	-1.2	1.4	-1.3
Bone: marrow area	0.9	2.0	3.3	-1.6	1.8	-0.4
Bone: maximum diameter	2.2	3.9	5.0	-2.2	2.2	-1.4
Bone: maximum force	2.8	4.9	6.2	-2.3	2.5	-1.8
Bone: maximum moment	2.3	4.0	4.5	-2.0	2.1	-1.8
Bone: minimum diameter	0.0	0.1	0.1	0.1	-0.2	-0.4
Bone: periosteal estimation	1.4	2.9	4.3	-1.9	2.1	-1.0
Bone: periosteal perimeter	0.4	0.7	1.3	-0.9	1.1	0.2
Bone: post-yield work	1.2	1.7	2.8	-1.5	1.7	-0.3
Bone: stiffness	4.0	6.3	7.8	-2.6	2.8	-2.1
Bone: tissue strength	0.4	0.4	1.1	-0.2	0.4	-1.0
Bone: trabecular number	1.3	1.9	2.2	-1.5	1.3	-1.3
Bone: trabecular spacing	0.1	0.1	0.4	0.1	-0.2	-0.6
Bone: trabecular thickness	0.1	0.1	0.1	0.3	-0.4	-0.0
Bone: trabecular tissue density	2.4	3.3	4.5	-1.9	2.1	-1.4
Breakpoint value in progressive ratio session	1.2	1.4	3.9	0.5	-0.2	2.0
Distance traveled before self-admin	3.7	4.0	6.6	-2.3	2.6	-0.1
Distance traveled after self-admin	0.8	0.9	1.4	-0.7	0.8	-1.2
Delta time in closed arm before/after self-admin	3.1	3.0	4.3	-1.7	1.3	-2.1
Delta time in open arm before/after self-admin	0.6	0.6	1.0	0.7	-0.4	1.0
Diff in mean of infusions in LGA sessions	0.0	0.0	0.1	0.2	-0.0	-0.3
Extinction: sum of active levers before priming	1.7	1.7	2.5	1.5	-1.6	0.7
Active lever presses in extinction session 6	0.5	0.4	0.6	0.5	-0.7	0.8
Delta distance traveled before/after self-admin	0.6	0.6	1.0	1.0	-0.9	-0.4
Delta ambulatory time before/after self-admin	1.5	1.6	2.5	1.6	-1.5	-0.2
Time in closed arm before self-admin	2.2	2.5	3.2	1.8	-1.7	1.2
Time in closed arm after self-admin	0.2	0.2	0.2	0.3	-0.5	-0.4
Time in open arm before self-admin	2.0	2.1	3.5	-1.7	1.9	0.0
Time in open arm after self-admin	1.2	1.3	2.1	-1.3	1.4	0.5
Sum of active levers in priming session hrs 5-6	3.5	3.5	3.7	1.8	-1.8	1.9
Time to tail flick, vehicle, before self-admin	1.1	1.1	1.6	1.2	-1.2	0.6
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	0.0	0.1	0.4
Time to tail flick, test, before self-admin	0.2	0.2	0.4	-0.6	0.2	-0.5
Time to tail flick, test, after self-admin	0.8	0.9	1.4	-0.9	0.6	-1.2
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.2	-0.4	0.5	-0.3
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	0.2	-0.1	-0.1
Ambulatory time before self-admin	2.9	3.0	5.0	-2.0	2.2	0.4
Ambulatory time after self-admin	0.1	0.1	0.2	-0.4	0.4	-0.2
Total heroin consumption	0.9	1.1	2.7	0.7	-0.4	1.6
Area under the delay curve	0.5	0.5	0.9	0.7	-0.5	1.0
Delay disc. indifference point, 0s delay	1.3	1.4	1.6	1.3	-1.1	1.2
Delay disc. indifference point, 16s delay	1.9	1.9	4.1	1.1	-0.7	2.0
Delay disc. indifference point, 2s delay	0.1	0.1	0.3	-0.1	-0.1	-0.6
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.4	-0.3	0.1
Delay disc. indifference point, 4s delay	0.1	0.1	0.1	0.3	-0.2	0.2
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	-0.1	0.2	-0.1
Delay discount exponential model param	0.4	0.4	0.8	-0.6	0.4	-0.9
Delay discount hyperbolic model param	0.3	0.4	0.7	-0.5	0.3	-0.8
Fecal boli incidents, locomotor time 1	0.6	0.7	1.3	0.8	-1.2	-0.1
Change in fecal boli incidents, locomotor task	1.2	1.1	1.9	-1.0	1.4	0.7
Time >=10cm from walls, locomotor time 1	0.4	0.4	1.1	-0.1	0.3	1.1
Bouts of movement, locomotor time 1	1.6	1.7	2.6	1.5	-1.6	0.5
Total resting periods, locomotor time 1	2.0	2.2	3.7	1.7	-1.9	0.1
Rest time, locomotor task time 1	2.5	2.8	3.8	1.3	-1.9	-1.7
Distance moved, locomotor task time 1	2.3	2.5	4.1	-1.5	2.0	1.0
Vertical activity count, locomotor time 1	1.9	1.9	2.8	-1.0	1.7	1.4
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.1	-0.3	0.4	0.0
Bouts of movement, locomotor time 2	0.5	0.5	0.7	-0.9	0.8	-0.4
Total resting periods, locomotor time 2	0.2	0.2	0.3	-0.5	0.4	-0.3
Rest time, locomotor task time 2	0.8	0.9	1.6	1.0	-1.2	0.1
Distance moved, locomotor task time 2	0.7	0.8	1.6	-0.6	0.7	-1.2
Vertical activity count, locomotor time 2	0.5	0.5	1.0	-0.7	1.0	-0.3
Weight adjusted by age	0.5	0.5	1.2	-0.4	0.4	1.1
Seeking ratio, delayed vs. immediate footshock	3.1	3.5	5.0	-2.2	2.0	-1.3
Locomotion in novel chamber	0.2	0.3	0.8	0.0	-0.2	-0.9
Locomotion in novel chamber post-restriction	2.4	2.9	5.4	-1.4	1.1	-2.3
Progressive ratio	0.0	0.0	0.0	0.1	-0.1	0.2
Food seeking constrained by brief footshock	6.4	7.8	12.7	-3.3	3.6	0.3
Seeking ratio, punishment vs. effort	1.6	1.9	3.0	-1.7	1.7	-0.1
Run reversals in cocaine runway, females	0.4	0.4	1.1	-0.2	0.3	-1.0
Run reversals in cocaine runway, males	0.0	0.0	0.1	0.1	-0.3	-0.0
Latency to leave start box in cocaine runway	0.6	0.7	0.8	-0.9	0.9	-0.7
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	0.1	0.0	0.3
Latency to leave start box in cocaine runway, M	1.3	1.2	2.2	-1.2	1.5	-0.1
Cd content in liver	1.0	1.1	2.0	-0.8	0.8	-1.4
Co content in liver	1.2	1.4	1.8	1.3	-1.0	1.2
Cu content in liver	0.9	1.1	1.6	1.3	-1.3	-0.4
Fe content in liver	0.6	0.7	1.7	-0.1	0.7	1.3
K content in liver	0.4	0.4	0.8	0.5	-0.4	0.9
Mg content in liver	0.5	0.6	0.7	0.7	-0.9	0.7
Mn content in liver	0.4	0.4	1.1	-0.4	0.2	-1.1
Na content in liver	1.1	1.2	2.2	1.5	-1.2	0.2
Rb content in liver	3.7	4.6	6.3	2.5	-2.3	1.5
Se content in liver	2.1	2.6	3.6	-1.5	1.4	-1.9
Sr content in liver	0.6	0.5	0.6	-0.8	0.7	-0.7
Zn content in liver	0.3	0.4	1.1	-0.3	0.0	-1.0