Maip1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000015983	0.03	0.02	4.0e-03	0.02	0.01	0.01	0.01	5.5e-03	1.6e-02	2.1e-02	5.2e-02
2	BLA	gene expression	ENSRNOG00000015983	0.17	0.08	6.8e-07	0.15	0.13	0.1	0.14	2.9e-08	3.0e-07	3.0e-06	5.5e-08
3	Brain	gene expression	ENSRNOG00000015983	0.07	0.04	1.1e-07	0.04	0.08	0.08	0.07	4.6e-05	4.2e-08	1.2e-07	4.7e-07
4	Liver	gene expression	ENSRNOG00000015983	0.05	0.03	4.6e-05	0.02	0.03	0.03	0.02	2.2e-03	4.2e-04	3.4e-04	2.0e-03
5	NAcc	gene expression	ENSRNOG00000015983	0.06	0.04	3.1e-04	0.04	0.04	0.04	0.05	9.4e-04	3.4e-04	3.1e-04	1.7e-04
6	PL	gene expression	ENSRNOG00000015983	0.05	0.03	3.3e-03	0.03	0.02	-0	0.02	1.6e-03	1.2e-02	3.6e-01	2.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
BMI with tail	2.5	8.2	17.9	-0.5	-2.6	-2.1	3.0	-3.4	-4.2
BMI without tail	0.9	2.0	7.8	0.8	-1.1	0.1	0.5	-1.3	-2.8
Body weight	0.4	1.8	7.8	2.8	0.8	1.3	0.3	0.9	0.0
Epididymis fat weight	1.7	3.9	5.9	1.6	2.4	2.3	-2.1	2.2	0.9
Glucose	0.6	0.9	2.0	-0.1	-0.6	-0.7	1.2	-1.0	-1.4
Heart weight	0.2	0.3	1.3	1.1	-0.3	0.1	0.5	0.1	0.1
Left kidney weight	0.2	0.5	1.6	1.3	0.2	-0.1	1.2	0.3	0.2
Right kidney weight	0.4	1.2	5.2	2.3	0.5	0.6	0.9	0.6	0.0
Tail length	4.5	13.5	19.9	2.9	3.3	3.5	-3.3	4.5	4.3
Length with tail	4.9	18.1	26.2	4.0	4.0	4.0	-3.2	5.1	4.9
Length without tail	1.2	2.6	5.9	1.3	1.6	1.1	-0.6	1.9	2.4
Liver weight, left	1.5	2.5	5.4	2.3	1.7	2.0	-0.8	1.5	-0.2
Liver weight, right	1.1	1.8	6.0	2.4	0.4	1.2	-0.5	1.2	1.3
Parametrial fat weight	0.0	0.1	0.2	-0.1	0.2	0.3	-0.3	0.0	-0.4
Retroperitoneal fat weight	0.3	1.0	2.0	1.4	1.1	1.3	-0.6	0.6	-0.6
Intraocular pressure	3.3	4.6	6.9	-1.3	-2.3	-2.4	2.5	-2.6	-1.2
Extensor digitorum longus weight	0.7	2.9	6.3	-1.5	-1.2	-1.5	1.0	-2.1	-2.5
Soleus weight	0.2	0.5	1.5	1.2	0.1	0.5	0.2	0.1	-1.1
Tibialis anterior weight	0.1	0.3	0.7	-0.9	-0.5	-0.4	-0.4	-0.6	-0.3
Tibia length	2.8	8.0	13.3	1.9	2.9	2.3	-2.1	3.6	3.7
Number of licking bursts	0.2	0.3	0.4	-0.3	-0.6	-0.6	0.5	-0.4	0.6
Food consumed during 24 hour testing period	1.6	1.9	2.8	-0.5	-1.4	-1.4	1.7	-1.6	-1.3
Times rat made contact with spout	1.1	1.2	2.3	-0.4	-1.2	-0.7	0.7	-1.5	-1.5
Mean time between licks in bursts	0.6	0.9	1.9	-0.7	1.2	0.7	-1.4	0.5	-0.7
Mean num. licks in bursts	0.4	0.5	2.5	-0.1	-0.2	-0.1	0.1	-0.6	-1.6
Std. dev. time between licks in bursts	0.9	1.1	2.0	-1.4	-0.9	-1.1	0.4	-1.2	-1.0
Water consumed over 24 hours	5.1	6.0	9.7	-0.9	-2.9	-2.5	2.6	-3.1	-2.0
Indifference point 0 sec	0.5	0.7	1.8	-0.4	-0.8	-1.2	1.3	-0.7	0.1
Indifference point AUC	0.2	0.3	1.4	-0.3	-0.1	-0.3	-0.1	0.2	1.2
Indifference point function ln k	0.1	0.1	0.4	0.3	0.1	0.3	-0.3	-0.1	-0.6
Indifference point function log k	0.1	0.1	0.4	0.3	0.1	0.3	-0.3	-0.1	-0.6
Delay discounting total patch changes 0 sec	0.9	1.4	3.0	-0.6	-1.2	-1.6	1.7	-1.1	0.0
Delay discounting total patch changes 12 sec	0.6	0.8	1.5	-0.8	-0.9	-1.2	1.1	-0.6	0.6
Delay discounting total patch changes 18 sec	2.4	3.1	5.5	-1.7	-1.6	-2.3	2.2	-1.7	-0.1
Delay discounting total patch changes 24 sec	0.3	0.3	1.1	-0.3	-0.5	-0.7	0.4	-0.1	1.0
Delay discounting total patch changes 6 sec	0.7	1.1	3.3	1.1	-1.1	-0.6	1.8	-0.6	-0.3
Delay discounting time to switch 0 sec	0.2	0.3	1.0	0.1	-0.4	-0.2	0.7	-0.5	-1.0
Delay discounting water rate 0 sec	0.3	0.5	0.7	0.7	0.7	0.5	-0.3	0.8	0.8
Delay discounting water rate 12 sec	0.4	0.7	2.5	1.6	-0.4	0.5	0.5	-0.2	-0.9
Delay discounting water rate 18 sec	0.2	0.2	0.6	0.7	-0.2	-0.3	0.8	0.0	0.5
Delay discounting water rate 24 sec	0.5	0.7	2.8	1.7	0.2	0.9	-0.1	0.2	-0.7
Delay discounting water rate 6 sec	0.1	0.2	0.6	0.8	0.1	0.3	0.4	0.1	-0.5
Locomotor activity	0.3	0.4	0.8	-0.5	-0.5	-0.7	0.9	-0.4	-0.8
Locomotor testing distance	2.0	3.2	5.9	-0.6	-1.9	-1.8	2.4	-1.8	-1.8
Locomotor testing rearing	0.1	0.2	0.7	0.2	-0.3	-0.2	0.4	-0.4	-0.8
Light reinforcement 1	2.3	4.3	10.3	-1.1	-1.3	-1.5	2.2	-2.3	-3.2
Light reinforcement 2	0.1	0.2	0.3	0.3	0.5	0.6	-0.3	0.5	-0.2
Reaction time number correct	1.1	1.6	2.6	0.3	-1.6	-0.9	1.6	-1.3	-1.4
Reaction time mean minus median	0.0	0.0	0.1	0.1	0.2	0.1	-0.3	0.2	0.1
Reaction time mean minus median AUC	0.2	0.2	0.5	-0.3	-0.7	-0.6	0.5	-0.5	-0.0
Reaction time num false alarms	0.5	0.7	2.4	-1.0	-0.3	-0.5	0.3	-0.8	-1.6
Reaction time num false alarms AUC	0.6	0.9	3.1	-1.0	-0.3	-0.5	0.5	-0.8	-1.8
Reaction time trials correct on left	1.1	1.6	2.6	0.3	-1.6	-0.9	1.6	-1.3	-1.4
Reaction time trials on left	1.0	1.5	2.4	0.3	-1.6	-0.8	1.5	-1.2	-1.3
Reaction time mean	2.9	3.9	6.7	-0.5	2.2	1.3	-2.6	2.1	2.4
Reaction time mean AUC	2.4	3.3	5.9	-0.7	2.0	1.1	-2.4	1.8	2.1
Median of all reaction times	4.4	6.0	9.5	-0.8	2.7	1.5	-3.1	2.6	3.0
Reaction time omissions	0.5	0.6	1.0	0.4	1.0	1.0	-0.8	1.0	0.1
Reaction time false alarm rate	0.2	0.4	0.8	-0.9	0.7	0.1	-0.5	0.0	-0.8
Reaction time premature initiation rate	1.2	1.7	3.3	-1.2	-1.6	-1.8	1.2	-1.0	0.4
Reaction time premature initiations	2.1	3.0	5.6	-0.9	-2.4	-2.1	2.0	-1.7	-0.5
Std. dev. reaction times	0.7	1.0	1.4	0.6	1.0	0.9	-1.2	1.1	1.0
Reaction time trials completed	1.0	1.5	2.4	0.3	-1.6	-0.8	1.5	-1.2	-1.3
Reaction time trials AUC	0.9	1.2	2.1	0.2	-1.5	-0.7	1.4	-1.1	-1.2
Social response proportion	1.1	1.2	3.0	1.7	0.9	1.1	-0.3	1.3	0.8
Social responses	0.9	1.2	2.6	0.4	1.3	1.0	-0.8	1.6	1.0
Social time	0.3	0.4	1.1	0.1	0.8	0.3	-0.0	1.0	0.9
Conditioned locomotion	1.4	1.7	2.7	0.7	1.6	1.4	-1.5	1.5	0.7
Cocaine response after cond. corrected	2.3	2.5	4.0	1.1	1.9	1.8	-1.4	2.0	1.1
Cocaine response after cond. not corrected	1.6	1.8	2.8	1.7	1.1	1.5	-0.8	1.7	1.1
Cocaine response before conditioning	1.4	1.7	4.5	0.2	-2.1	-1.3	1.5	-1.2	-0.1
Saline control response	0.3	0.4	0.8	0.9	-0.8	-0.1	0.9	-0.5	-0.5
Condit. Reinf. active minus inactive responses	0.6	0.7	2.3	0.8	0.1	0.4	-0.6	0.9	1.5
Condit. Reinf. active-inactive response ratio	0.6	0.7	2.4	-0.3	-0.9	-0.8	0.2	-0.0	1.5
Condit. Reinf. active responses	0.4	0.6	2.0	0.2	0.0	0.3	-1.0	0.8	1.4
Condit. Reinf. inactive responses	0.2	0.2	0.7	-0.0	0.4	0.4	-0.9	0.4	0.0
Condit. Reinf. lever presses	1.2	1.7	3.0	-1.3	-1.6	-1.7	1.1	-1.2	0.3
Condit. Reinf. lever reinforcers received	0.4	0.6	2.0	0.1	-0.1	0.1	-0.9	0.7	1.4
Pavlov. Cond. lever latency	1.6	2.2	3.9	1.9	1.8	2.0	-0.7	1.3	-0.7
Pavlov. Cond. magazine entry latency	0.6	0.7	1.3	-1.1	-0.7	-1.1	0.8	-0.6	0.7
Pavlov. Cond. change in total contacts	1.2	1.7	6.5	-1.6	0.2	-0.8	-0.6	0.7	2.5
Pavlov. Cond. index score	1.1	1.5	3.6	-1.9	-0.9	-1.5	0.2	-0.4	1.5
Pavlov. Cond. latency score	1.1	1.4	3.1	-1.8	-0.9	-1.4	0.4	-0.4	1.4
Pavlov. Cond. lever contacts	1.4	2.0	3.9	-2.0	-1.4	-1.9	0.5	-0.9	1.1
Pavlov. Cond. magazine entry number	0.4	0.4	1.2	0.7	0.3	0.8	-0.5	0.1	-1.1
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.3	0.6	-0.7	0.1	-0.0	-0.5	-1.1
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	3.5	-1.9	-0.7	-1.3	0.1	-0.3	1.6
Pavlov. Cond. response bias	0.9	1.2	2.4	-1.5	-1.1	-1.4	0.4	-0.6	1.1
Conditioned reinforcement - actives	0.2	0.2	0.6	-0.0	0.8	0.3	-0.1	0.6	0.4
Conditioned reinforcement - inactives	0.9	1.0	2.4	-1.2	1.0	0.0	-0.5	1.0	1.6
Conditioned locomotion	0.3	0.4	1.6	0.5	-0.0	0.0	0.5	-0.5	-1.3
Intermittent access intake day 1-15 change	2.0	2.0	4.4	0.3	-2.1	-1.3	1.6	-1.6	-0.9
Intermittent access intake escalation	1.8	1.8	4.2	0.1	-2.0	-1.3	1.5	-1.5	-0.6
Intermittent access intake escalation 2	0.9	0.8	2.5	0.8	-1.6	-0.6	0.9	-0.9	-0.2
Intermitt. access day 1 inactive lever presses	1.5	1.6	3.5	-1.9	-1.0	-1.5	0.9	-1.3	-0.7
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.7	-0.2	-0.8	-0.6	0.4	-0.5	0.0
Intermitt. access escalation Index	0.5	0.5	1.8	-0.4	1.3	0.4	-0.2	0.8	0.2
Intermittent access day 1 total infusions	0.2	0.3	0.9	-0.9	0.4	-0.0	-0.2	0.3	0.6
Intermittent access day 15 total infusions	0.8	0.9	1.5	-0.9	-1.1	-1.1	1.2	-0.8	0.3
Intermittent access terminal intake (last 3 days)	1.3	1.4	2.8	-1.0	-1.3	-1.4	1.7	-1.1	-0.0
Intermittent access total infusions	0.5	0.5	1.3	-1.2	-0.4	-0.8	0.7	-0.4	0.4
Intermittent access day 1 locomotion	0.8	0.8	3.5	-1.9	0.1	-0.9	0.5	-0.2	0.5
Intermittent access day 15 total locomotion	0.7	0.7	1.2	-0.9	-0.8	-1.1	1.1	-0.6	0.4
Intermittent access total locomotion	0.2	0.2	0.7	-0.8	-0.0	-0.4	0.5	-0.2	0.1
Intermittent access standard deviation	2.2	2.3	3.8	-1.6	-1.9	-1.8	1.4	-1.6	-0.1
Cocaine induced anxiety	0.1	0.2	0.7	0.3	0.3	0.2	-0.1	-0.1	-0.8
Post-drug Anxiety	0.2	0.2	0.4	0.5	-0.3	0.3	-0.6	-0.2	-0.5
Baseline Anxiety	0.5	0.5	1.6	-0.1	-0.0	0.3	-1.0	0.5	1.3
Lifetime Intake	0.3	0.3	1.1	-1.1	-0.2	-0.6	0.6	-0.4	0.0
Incentive Sensitization - Responses	0.5	0.5	1.0	-0.4	0.9	0.4	-0.6	0.9	1.0
Incentive Sensitization - Breakpoint	0.5	0.5	0.8	-0.4	0.9	0.3	-0.6	0.8	0.9
Progressive ratio test 1 active lever presses	0.9	1.0	3.3	-1.8	-0.3	-1.2	0.8	-0.5	0.4
Progressive ratio test 1 breakpoint	1.2	1.2	2.8	-1.7	-0.8	-1.4	1.0	-0.8	0.5
Progressive ratio test 1 inactive lever presses	2.9	3.1	6.4	-2.5	-1.0	-2.0	1.3	-1.9	-1.5
Progressive ratio test 2 active lever presses	0.6	0.6	2.1	-1.4	0.0	-0.8	0.6	-0.0	0.8
Progressive ratio test 2 breakpoint	1.0	1.1	3.0	-1.7	-0.4	-1.3	1.0	-0.5	0.5
Progressive ratio test 2 inactive lever presses	0.7	0.8	3.2	-1.8	-0.1	-1.1	0.6	-0.6	-0.1
Total sessions with >9 infusions	1.1	1.2	2.0	-1.4	-0.5	-1.2	1.1	-1.1	-1.0
Short access day 1 total inactive lever presses	0.0	0.0	0.1	0.1	-0.1	-0.1	0.2	-0.2	-0.2
Short access day 10 total inactive lever presses	0.3	0.3	0.8	-0.4	-0.9	-0.5	-0.4	-0.8	-0.4
Short access day 1 total infusions	0.7	0.7	1.2	-1.0	-0.5	-0.9	1.1	-0.9	-0.6
Short access day 10 total infusions	0.1	0.1	0.2	-0.5	-0.1	-0.3	0.2	-0.1	0.2
Short access total infusions	0.5	0.5	1.0	-1.0	-0.4	-0.8	0.6	-0.8	-0.5
Short access day 1 locomotion	1.5	1.5	4.9	-2.2	-0.4	-1.5	1.1	-0.6	0.4
Short access day 10 total locomotion	0.5	0.6	1.4	-1.2	-0.5	-0.8	0.9	-0.5	0.3
Short access total locomotion	0.3	0.3	0.5	-0.7	-0.3	-0.6	0.7	-0.6	-0.4
Compulsive drug intake	0.4	0.4	1.4	-1.2	0.2	-0.4	-0.3	0.3	0.9
One hour access (0.3 mA shock)	1.2	1.5	5.0	-2.2	-0.4	-1.2	0.5	-0.2	1.3
One hour access (shock baseline)	0.2	0.2	0.6	-0.8	-0.2	-0.4	0.2	-0.1	0.6
Number of responses in last shaping day	0.5	0.5	1.2	-1.0	-0.3	-1.0	1.1	-0.3	0.2
Context. condit. distance diff. score	0.1	0.1	0.2	-0.5	-0.4	0.1	-0.2	-0.4	-0.4
Locomotion velocity, session 1	0.7	0.7	1.3	-1.1	-0.7	-0.4	-0.2	-1.0	-1.2
Locomotion distance, session 1	1.0	1.3	2.4	-0.5	-1.5	-0.6	0.3	-1.5	-1.5
Locomotion velocity, session 2	0.3	0.3	0.9	-0.5	-0.3	0.1	-0.5	-0.5	-0.9
Locomotion distance, session 2	0.7	0.9	4.2	0.1	-0.2	0.4	-0.6	-0.9	-2.1
Locomotion velocity, session 3	0.2	0.3	0.8	0.4	-0.2	0.5	-0.4	-0.4	-0.9
Locomotion distance, session 3	0.3	0.3	1.4	-0.2	0.2	0.5	-1.2	0.2	0.4
Stereotopy head waving bouts, day 3	0.8	0.9	1.6	-0.9	-0.8	-1.2	1.3	-0.9	0.1
Stereotopy head waving duration, day 3	1.3	1.6	4.6	0.2	-1.1	-1.0	2.1	-1.2	-1.2
Locomotion velocity, session 7	0.5	0.5	0.9	-0.4	-0.6	-0.6	0.8	-0.9	-0.8
Locomotion distance, session 7	0.2	0.2	0.7	-0.5	-0.0	0.0	-0.5	-0.4	-0.8
Stereotopy head waving bouts, day 7	0.5	0.6	1.6	1.3	0.2	0.8	-0.3	0.7	0.9
Stereotopy head waving duration, day 7	0.4	0.4	2.1	1.4	-0.2	0.6	0.3	0.0	-0.4
Locomotion velocity, session 8	0.1	0.2	0.5	0.5	0.1	0.7	-0.3	0.2	-0.3
Locomotion distance, session 8	0.3	0.4	1.1	-0.6	-0.3	0.3	-1.1	-0.5	-0.7
Degree of sensitization distance	0.5	0.5	1.0	-0.1	-0.5	-0.5	0.9	-0.7	-1.0
Degree of sensitization stereotypy	1.5	1.7	3.6	1.9	0.8	1.7	-1.1	1.2	0.3
Condit. Reinf. active minus inactive responses	0.5	0.6	2.3	-0.3	-0.6	-0.7	0.4	0.2	1.5
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.7	0.1	-0.5	-0.6	0.8	-0.0	0.7
Condit. Reinf. active responses	0.8	1.0	3.9	0.1	0.3	0.2	-0.8	1.0	2.0
Condit. Reinf. inactive responses	0.8	0.9	2.1	-0.1	1.0	0.7	-1.4	1.0	1.0
Incentive salience index mean	0.8	0.9	4.7	-0.2	-0.2	-0.4	-0.1	0.7	2.2
Condit. Reinf. lever presses	0.9	1.2	4.5	-0.1	0.5	0.2	-1.0	1.0	2.1
Time in familiar zone, hab. session 1	0.4	0.3	0.9	0.9	-0.9	0.2	0.5	-0.1	-0.1
Time in novel zone, hab. session 1	0.3	0.3	0.7	-0.8	0.8	0.0	-0.5	0.3	0.3
Total zone transitions, hab. session 1	0.2	0.3	1.2	0.4	-0.1	0.6	-1.1	0.2	0.1
Total locomotion distance, hab. session 1	0.2	0.3	1.5	0.1	-0.4	-0.1	-0.4	0.2	1.2
Locomotion velocity, hab. session 1	0.2	0.3	1.3	0.1	-0.1	-0.1	-0.4	0.3	1.2
Time in familiar zone, hab. session 2	1.5	1.5	2.5	-1.3	-1.6	-1.6	1.1	-1.2	-0.0
Time in novel zone, hab. session 2	0.4	0.4	0.9	0.8	1.0	0.8	-0.1	0.3	-0.6
Total zone transitions, hab. session 2	0.7	0.9	3.2	0.2	-0.9	-0.1	0.3	-1.1	-1.8
Total locomotion distance, hab. session 2	0.6	0.8	2.3	0.3	-0.9	-0.2	0.5	-1.0	-1.5
Locomotion velocity, hab. session 2	0.5	0.6	2.0	0.3	-0.7	-0.2	0.6	-0.9	-1.4
Novel to familiar place preference ratio	0.5	0.5	1.3	1.1	-0.1	0.4	0.5	-0.2	-1.2
Novelty place preference	0.5	0.5	1.3	1.1	-0.2	0.3	0.7	-0.3	-1.1
Time in novel zone, NPP test	0.6	0.7	1.7	1.1	-0.5	0.2	0.8	-0.5	-1.3
Total zone transitions, NPP test	0.2	0.3	0.7	-0.6	-0.9	-0.1	-0.7	-0.5	-0.4
Total locomotion distance, NPP test	1.1	1.5	3.8	-0.7	-1.9	-1.3	0.8	-1.5	-0.5
Locomotion velocity, NPP test	1.2	1.7	3.4	-1.0	-1.8	-1.5	0.9	-1.5	-0.5
Pavlov. Cond. lever latency	0.3	0.4	1.2	-0.4	0.0	-0.5	0.6	-0.8	-1.1
Pavlov. Cond. magazine entry latency	0.5	0.6	2.3	-0.2	-0.8	-0.7	0.1	0.1	1.5
Pavlov. Cond. change in total contacts	0.3	0.3	1.1	0.1	-0.7	-0.4	0.2	0.1	1.1
Pavlov. Cond. index score	0.5	0.6	3.0	-0.2	-0.6	-0.4	-0.3	0.4	1.7
Pavlov. Cond. latency score	0.4	0.6	2.7	0.1	-0.6	-0.1	-0.3	0.5	1.6
Pavlov. Cond. lever contacts	0.2	0.2	0.9	-0.0	-0.6	-0.2	-0.0	0.1	0.9
Pavlov. Cond. magazine entry number	0.3	0.4	1.8	-0.2	0.3	0.3	-0.2	-0.4	-1.3
Pavlov. Cond. intertrial magazine entries	0.9	1.0	1.7	1.1	1.3	1.3	-0.7	1.1	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	2.8	-0.6	-0.8	-0.7	-0.1	0.1	1.7
Pavlov. Cond. response bias	0.5	0.6	2.8	-0.3	-0.4	-0.5	-0.1	0.4	1.7
Bone: apparent density	0.8	1.3	6.1	2.5	-0.2	0.9	0.5	0.8	0.3
Bone surface	2.2	3.8	6.3	2.5	1.6	1.9	-0.9	2.5	1.9
Bone volume	1.2	2.0	4.9	2.2	0.7	1.3	-0.3	1.7	1.2
Bone: connectivity density	0.8	1.3	5.9	2.4	-0.0	0.9	0.5	0.7	-0.0
Bone: cortical apparent density	3.3	4.3	8.0	-2.8	-1.3	-2.6	1.8	-2.2	-1.1
Bone: cortical area	1.1	1.6	4.3	-0.6	1.5	0.1	-0.7	1.5	2.1
Bone: cortical porosity	2.6	2.8	6.0	0.5	1.4	1.1	-1.6	2.1	2.4
Bone: cortical porosity	2.9	3.1	6.5	0.9	1.4	1.3	-1.6	2.3	2.5
Bone: cortical thickness	0.7	1.1	4.3	-2.1	0.1	-1.3	0.3	-0.3	0.6
Bone: cortical thickness	1.9	2.2	3.4	-1.2	-1.7	-1.9	1.6	-1.7	-0.4
Bone: cortical tissue density	3.3	4.3	7.3	-2.7	-1.4	-2.5	1.8	-2.2	-1.3
Bone: elastic displacement	1.3	1.5	3.8	-0.0	-1.9	-1.0	1.1	-1.5	-0.8
Bone: elastic work	0.1	0.2	0.5	0.5	-0.7	-0.2	0.5	-0.2	0.1
Bone: endosteal estimation	1.5	3.3	5.7	1.8	1.8	1.3	-0.7	2.3	2.4
Bone: endosteal perimeter	1.8	3.7	5.9	2.0	2.0	1.7	-1.0	2.4	2.1
Bone: final force	1.0	1.6	3.5	-0.0	1.5	0.5	-0.9	1.6	1.9
Bone: final moment	0.3	0.6	1.8	-0.2	0.8	-0.1	-0.3	0.9	1.4
Bone: marrow area	1.5	3.2	6.1	1.7	1.8	1.2	-0.6	2.3	2.5
Bone: maximum diameter	2.1	3.8	8.2	-0.2	2.2	1.0	-1.6	2.5	2.9
Bone: maximum force	0.5	0.9	1.9	0.9	0.9	0.4	-0.3	1.3	1.4
Bone: maximum moment	0.2	0.3	0.6	0.7	0.1	-0.1	0.4	0.5	0.8
Bone: minimum diameter	0.9	1.7	5.1	-0.2	1.5	0.1	-0.5	1.5	2.2
Bone: periosteal estimation	1.7	3.4	8.4	0.6	2.1	0.9	-1.0	2.4	2.9
Bone: periosteal perimeter	1.1	1.9	4.5	0.7	1.4	0.7	-0.6	1.8	2.1
Bone: post-yield work	0.6	0.9	3.2	0.9	-0.5	-0.7	1.8	-0.5	-0.2
Bone: stiffness	2.4	3.9	6.4	1.5	2.2	1.7	-1.6	2.5	2.1
Bone: tissue strength	0.2	0.2	0.6	0.8	0.1	0.3	0.1	0.3	-0.4
Bone: trabecular number	1.1	1.7	6.9	2.6	0.2	1.4	-0.2	1.0	0.2
Bone: trabecular spacing	0.2	0.3	0.8	-0.9	0.8	0.1	-0.5	0.1	0.1
Bone: trabecular thickness	0.5	0.6	1.2	1.1	-1.0	-0.1	0.9	-0.3	-0.5
Bone: trabecular tissue density	1.2	1.6	6.2	-2.5	0.2	-1.0	-0.7	0.1	1.4
Breakpoint value in progressive ratio session	0.3	0.4	0.6	-0.4	-0.7	-0.6	0.7	-0.1	0.8
Distance traveled before self-admin	0.6	0.7	1.3	1.1	-0.2	0.7	-0.6	0.8	1.1
Distance traveled after self-admin	0.2	0.2	0.3	0.3	0.2	0.4	-0.6	0.4	0.4
Delta time in closed arm before/after self-admin	0.2	0.2	0.4	-0.6	0.1	-0.0	-0.6	0.1	0.4
Delta time in open arm before/after self-admin	1.9	1.8	4.9	1.1	0.7	1.0	-0.7	1.7	2.2
Diff in mean of infusions in LGA sessions	0.3	0.4	1.1	1.0	-1.1	-0.0	0.4	-0.2	0.2
Extinction: sum of active levers before priming	0.3	0.3	1.4	1.2	-0.2	0.2	0.7	0.3	0.1
Active lever presses in extinction session 6	0.5	0.4	0.9	-0.1	0.8	0.7	-0.9	0.7	0.4
Delta distance traveled before/after self-admin	0.4	0.4	0.9	-0.6	-0.2	-0.6	0.4	-0.7	-0.9
Delta ambulatory time before/after self-admin	0.3	0.4	1.4	-1.2	0.4	-0.4	0.2	-0.4	-0.5
Time in closed arm before self-admin	1.0	1.1	3.1	0.8	0.6	0.8	-0.7	1.2	1.8
Time in closed arm after self-admin	0.5	0.6	1.0	0.7	0.3	0.8	-0.8	0.7	1.0
Time in open arm before self-admin	2.1	2.2	5.9	-1.5	-0.5	-1.3	0.9	-1.6	-2.4
Time in open arm after self-admin	0.4	0.5	1.4	-0.2	0.6	0.3	-0.5	0.9	1.2
Sum of active levers in priming session hrs 5-6	1.4	1.4	2.4	0.7	1.6	1.3	-1.0	1.5	0.7
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	-0.3	0.3	-0.1	0.3	0.0	0.5
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.2	-0.4	0.0	-0.1	-0.3	0.0	-0.3
Time to tail flick, test, before self-admin	0.3	0.3	0.8	-0.7	0.5	0.3	-0.9	0.2	0.1
Time to tail flick, test, after self-admin	1.7	1.8	3.4	-0.6	-1.8	-1.1	0.5	-1.8	-1.4
Delta time to tail flick, vehicle, before/after SA	0.5	0.4	1.6	0.2	-0.7	-0.2	-0.1	-0.6	-1.3
Delta time to tail flick, test, before/after SA	2.6	2.4	4.6	-0.5	-2.2	-1.6	1.5	-1.8	-1.0
Ambulatory time before self-admin	0.7	0.7	2.3	1.5	-0.2	0.9	-0.7	0.5	0.1
Ambulatory time after self-admin	0.0	0.0	0.0	0.2	0.1	0.0	0.2	0.0	-0.2
Total heroin consumption	0.2	0.2	0.6	-0.2	-0.2	-0.4	0.8	0.1	0.4
Area under the delay curve	0.5	0.5	0.9	0.8	1.0	0.9	-0.3	0.8	-0.0
Delay disc. indifference point, 0s delay	1.4	1.6	4.4	0.2	-0.9	-0.6	1.4	-1.4	-2.1
Delay disc. indifference point, 16s delay	0.6	0.6	0.8	0.5	0.6	0.8	-0.8	0.9	0.9
Delay disc. indifference point, 2s delay	1.4	1.5	3.8	0.9	-0.8	-0.2	1.7	-1.0	-2.0
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	-0.1	0.3	0.0	-0.3	0.3	0.4
Delay disc. indifference point, 4s delay	0.5	0.5	1.8	0.6	-0.0	0.2	0.7	-0.4	-1.3
Delay disc. indifference point, 8s delay	2.3	2.3	3.9	1.2	2.0	1.6	-1.2	2.0	1.0
Delay discount exponential model param	0.5	0.5	0.9	-0.9	-0.9	-0.9	0.2	-0.8	-0.0
Delay discount hyperbolic model param	0.4	0.4	0.8	-0.9	-0.8	-0.8	-0.1	-0.6	0.3
Fecal boli incidents, locomotor time 1	0.5	0.6	1.2	1.1	0.4	0.7	0.6	0.9	0.8
Change in fecal boli incidents, locomotor task	0.1	0.0	0.1	-0.1	0.2	-0.1	0.4	0.2	-0.2
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.8	-0.2	0.8	0.1	0.3	0.9	0.8
Bouts of movement, locomotor time 1	1.2	1.3	4.2	-1.5	-0.3	-0.9	0.3	0.3	2.0
Total resting periods, locomotor time 1	1.7	1.9	5.4	-2.3	-0.5	-1.4	0.3	-0.2	1.9
Rest time, locomotor task time 1	1.6	1.7	7.5	-2.7	0.3	-1.1	-0.3	-0.1	1.3
Distance moved, locomotor task time 1	1.4	1.6	4.3	2.1	1.1	1.5	-0.5	1.1	-0.2
Vertical activity count, locomotor time 1	0.6	0.7	1.7	1.3	0.6	1.0	-0.6	0.3	-0.6
Time >=10cm from walls, locomotor time 2	0.6	0.6	2.4	0.9	0.5	0.6	-0.0	-0.0	-1.6
Bouts of movement, locomotor time 2	0.0	0.0	0.0	0.1	-0.0	-0.0	-0.0	-0.0	0.1
Total resting periods, locomotor time 2	0.1	0.1	0.2	-0.5	-0.2	-0.4	0.2	-0.1	0.4
Rest time, locomotor task time 2	1.3	1.5	5.9	-2.4	0.5	-0.9	-0.2	0.2	1.5
Distance moved, locomotor task time 2	0.5	0.6	2.4	1.6	0.3	0.5	0.3	0.3	-0.6
Vertical activity count, locomotor time 2	1.4	1.6	4.8	1.2	-0.8	-0.3	1.1	-1.1	-2.2
Weight adjusted by age	0.5	0.5	1.7	1.3	-1.2	0.0	0.2	-0.3	-0.1
Seeking ratio, delayed vs. immediate footshock	1.2	1.4	3.6	1.9	0.7	1.4	-0.7	1.1	0.6
Locomotion in novel chamber	6.1	7.6	14.3	-1.1	-3.8	-2.9	3.0	-3.2	-1.5
Locomotion in novel chamber post-restriction	1.2	1.4	2.7	-1.2	-1.2	-1.6	1.2	-0.8	0.8
Progressive ratio	0.3	0.4	1.8	-1.4	0.2	-0.5	-0.3	-0.4	-0.2
Food seeking constrained by brief footshock	0.2	0.3	1.0	1.0	-0.3	0.3	-0.7	0.1	0.4
Seeking ratio, punishment vs. effort	1.0	1.3	5.6	2.4	0.1	1.1	-0.4	0.8	0.4
Run reversals in cocaine runway, females	0.1	0.1	0.2	0.2	-0.0	0.0	0.4	-0.1	-0.4
Run reversals in cocaine runway, males	0.6	0.6	1.2	-0.9	-0.6	-0.7	0.8	-0.2	1.1
Latency to leave start box in cocaine runway	2.4	2.7	4.8	-1.3	-1.3	-1.6	1.2	-2.0	-2.2
Latency to leave start box in cocaine runway, F	1.3	1.5	3.2	-1.0	-0.7	-1.1	1.1	-1.3	-1.8
Latency to leave start box in cocaine runway, M	2.2	2.1	4.4	-0.8	-2.1	-1.6	0.9	-1.9	-0.8
Cd content in liver	0.0	0.1	0.2	-0.0	0.0	0.3	-0.4	0.2	0.1
Co content in liver	1.0	1.2	3.1	-1.4	-1.8	-0.9	-0.5	-1.1	0.2
Cu content in liver	0.4	0.4	0.9	-0.1	0.9	0.2	-0.5	0.7	1.0
Fe content in liver	0.3	0.3	0.8	0.6	-0.9	-0.4	0.6	-0.5	0.2
K content in liver	0.7	0.7	1.5	0.4	1.2	0.6	-0.5	0.9	1.0
Mg content in liver	0.4	0.4	1.3	1.2	0.5	0.3	0.8	0.2	0.0
Mn content in liver	1.7	1.9	3.0	-1.4	-1.2	-1.7	1.6	-1.6	-0.4
Na content in liver	0.8	0.8	2.4	0.2	1.0	0.2	-0.4	1.1	1.5
Rb content in liver	2.0	2.5	4.4	1.7	1.5	2.1	-1.5	1.7	0.2
Se content in liver	0.2	0.3	0.5	-0.2	-0.6	-0.7	0.7	-0.6	-0.1
Sr content in liver	0.5	0.5	2.2	-1.5	0.7	-0.4	-0.1	0.0	0.2
Zn content in liver	0.1	0.1	0.4	-0.3	0.6	0.2	-0.3	0.1	-0.3