Hub : Genes

Lpar6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000015577	0.07	0.04	1.3e-06	0.05	0.04	0.05	0.05	4.6e-06	8.1e-06	1.3e-06	5.0e-06
2	Brain	gene expression	ENSRNOG00000015577	0.03	0.03	5.1e-03	0.01	0.01	0	0	6.6e-02	1.5e-02	1.9e-01	1.4e-01
3	Liver	gene expression	ENSRNOG00000015577	0.05	0.04	8.1e-04	0.01	0.02	0.01	0.01	2.2e-02	4.1e-03	6.1e-02	1.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
BMI with tail	0.2	0.5	0.9	-0.0	-0.8	0.9
BMI without tail	0.8	1.6	3.1	0.6	-1.8	1.1
Body weight	0.4	1.6	3.7	1.9	0.2	-1.1
Epididymis fat weight	0.9	2.0	3.8	1.9	-1.5	-0.2
Glucose	1.1	1.7	3.6	-0.5	-1.2	1.9
Heart weight	0.0	0.1	0.2	0.1	0.1	-0.4
Left kidney weight	1.1	3.2	6.1	2.5	-0.1	-1.9
Right kidney weight	2.2	6.2	9.3	3.1	0.2	-3.0
Tail length	0.7	2.1	4.8	2.2	-0.4	-1.2
Length with tail	0.7	2.5	3.6	1.7	1.0	-1.9
Length without tail	1.0	2.1	4.0	-0.3	2.0	-1.5
Liver weight, left	0.2	0.3	0.7	-0.1	0.8	-0.4
Liver weight, right	0.0	0.1	0.1	-0.0	0.3	0.3
Parametrial fat weight	1.0	1.9	3.6	0.5	-1.9	1.4
Retroperitoneal fat weight	0.2	0.8	1.6	0.7	-1.3	0.6
Intraocular pressure	0.6	0.9	2.1	1.4	-0.7	0.2
Extensor digitorum longus weight	3.1	12.4	22.5	-4.7	3.8	-0.3
Soleus weight	2.3	6.6	14.8	-3.9	2.1	0.7
Tibialis anterior weight	1.9	6.4	9.6	-3.1	3.0	-0.7
Tibia length	4.9	13.9	29.9	5.5	-0.0	-3.4
Number of licking bursts	0.8	1.0	1.3	1.1	-1.1	0.8
Food consumed during 24 hour testing period	0.4	0.4	0.8	0.7	0.3	-0.9
Times rat made contact with spout	2.3	2.6	3.9	2.0	-1.8	0.8
Mean time between licks in bursts	0.1	0.1	0.2	0.1	-0.5	0.1
Mean num. licks in bursts	0.0	0.0	0.1	0.3	-0.1	-0.0
Std. dev. time between licks in bursts	1.7	2.0	3.9	1.4	0.6	-2.0
Water consumed over 24 hours	0.1	0.1	0.2	0.4	0.2	-0.4
Indifference point 0 sec	3.3	5.3	11.9	3.5	-0.2	-2.0
Indifference point AUC	1.3	1.5	2.4	-1.5	-0.3	1.4
Indifference point function ln k	1.2	1.7	2.9	1.7	0.2	-1.5
Indifference point function log k	1.2	1.7	2.9	1.7	0.2	-1.5
Delay discounting total patch changes 0 sec	3.3	5.3	11.9	3.5	-0.0	-2.0
Delay discounting total patch changes 12 sec	1.0	1.4	2.9	1.7	0.3	-1.1
Delay discounting total patch changes 18 sec	0.6	0.8	1.5	1.2	-0.8	0.5
Delay discounting total patch changes 24 sec	1.5	1.9	4.3	2.1	0.2	-1.1
Delay discounting total patch changes 6 sec	1.3	2.0	3.5	1.9	-1.5	0.5
Delay discounting time to switch 0 sec	0.1	0.1	0.2	-0.1	0.4	-0.4
Delay discounting water rate 0 sec	0.6	1.0	2.9	1.7	-0.1	-0.4
Delay discounting water rate 12 sec	0.0	0.0	0.0	-0.0	0.1	-0.1
Delay discounting water rate 18 sec	0.2	0.3	0.5	-0.1	-0.6	0.7
Delay discounting water rate 24 sec	1.1	1.5	2.1	0.7	-1.3	1.4
Delay discounting water rate 6 sec	0.2	0.3	0.7	-0.0	0.8	-0.3
Locomotor activity	6.3	10.0	15.6	0.1	3.9	-3.8
Locomotor testing distance	4.7	7.8	12.6	1.0	3.1	-3.6
Locomotor testing rearing	5.7	8.9	14.8	1.5	3.1	-3.9
Light reinforcement 1	1.7	3.1	5.4	1.6	-2.3	1.2
Light reinforcement 2	3.7	4.9	7.7	-0.2	-2.8	2.6
Reaction time number correct	1.6	2.2	3.5	-1.9	-0.5	1.7
Reaction time mean minus median	2.6	3.4	5.2	0.6	2.1	-2.3
Reaction time mean minus median AUC	0.9	1.1	1.8	0.6	1.1	-1.4
Reaction time num false alarms	0.0	0.0	0.0	0.1	-0.2	-0.1
Reaction time num false alarms AUC	0.1	0.1	0.3	0.2	-0.6	0.1
Reaction time trials correct on left	1.6	2.2	3.5	-1.9	-0.5	1.7
Reaction time trials on left	1.5	2.2	3.2	-1.8	-0.5	1.8
Reaction time mean	1.7	2.3	4.0	-0.0	1.7	-2.0
Reaction time mean AUC	2.2	2.9	4.6	-0.2	2.0	-2.2
Median of all reaction times	0.9	1.3	2.3	-0.3	1.2	-1.5
Reaction time omissions	0.3	0.4	0.8	0.9	0.1	-0.7
Reaction time false alarm rate	0.4	0.5	1.1	1.1	-0.5	-0.5
Reaction time premature initiation rate	0.5	0.7	1.1	-0.9	-0.6	1.0
Reaction time premature initiations	1.8	2.6	3.8	-1.8	-0.8	1.9
Std. dev. reaction times	1.7	2.4	3.6	0.1	1.9	-1.9
Reaction time trials completed	1.5	2.2	3.2	-1.8	-0.5	1.8
Reaction time trials AUC	1.6	2.3	3.5	-1.9	-0.5	1.8
Social response proportion	3.1	3.3	4.5	-2.1	-1.1	2.1
Social responses	0.8	1.0	1.1	-0.9	-1.1	1.1
Social time	0.5	0.6	1.3	0.6	0.4	-1.1
Conditioned locomotion	0.5	0.6	0.8	-0.7	-0.7	0.9
Cocaine response after cond. corrected	2.2	2.5	4.2	-2.1	-0.5	1.7
Cocaine response after cond. not corrected	0.8	0.9	1.3	-1.1	-0.5	1.2
Cocaine response before conditioning	2.4	3.0	6.4	2.5	0.0	-1.6
Saline control response	0.8	1.0	2.8	1.7	0.1	-0.6
Condit. Reinf. active minus inactive responses	0.2	0.3	0.5	0.7	-0.5	-0.0
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.1	-0.5	0.4
Condit. Reinf. active responses	0.5	0.7	1.5	1.2	-0.8	-0.0
Condit. Reinf. inactive responses	0.9	1.2	3.0	1.7	-0.6	-0.3
Condit. Reinf. lever presses	1.8	2.4	3.7	1.8	0.6	-1.9
Condit. Reinf. lever reinforcers received	0.6	0.9	2.1	1.4	-0.7	-0.3
Pavlov. Cond. lever latency	1.4	1.9	3.7	-0.9	-1.1	1.9
Pavlov. Cond. magazine entry latency	1.4	1.6	3.0	1.1	0.8	-1.7
Pavlov. Cond. change in total contacts	1.6	2.3	3.4	-0.9	1.9	-1.6
Pavlov. Cond. index score	2.0	2.6	4.9	0.7	1.6	-2.2
Pavlov. Cond. latency score	2.3	2.9	5.5	0.7	1.6	-2.3
Pavlov. Cond. lever contacts	2.4	3.3	6.1	1.1	1.7	-2.5
Pavlov. Cond. magazine entry number	0.8	0.9	1.8	-0.9	-0.4	1.3
Pavlov. Cond. intertrial magazine entries	2.7	3.5	5.0	2.2	-2.2	0.8
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.1	4.1	0.5	1.4	-2.0
Pavlov. Cond. response bias	2.6	3.6	6.4	1.1	1.8	-2.5
Conditioned reinforcement - actives	2.2	2.2	3.7	-0.9	-1.5	1.9
Conditioned reinforcement - inactives	1.0	1.1	2.6	1.6	-0.7	-0.4
Conditioned locomotion	0.0	0.0	0.0	-0.0	-0.1	-0.1
Intermittent access intake day 1-15 change	1.3	1.3	2.7	1.7	-1.1	0.1
Intermittent access intake escalation	1.2	1.1	2.3	1.5	-1.0	0.3
Intermittent access intake escalation 2	0.3	0.3	0.5	0.4	-0.7	0.3
Intermitt. access day 1 inactive lever presses	0.5	0.5	1.4	1.2	-0.4	-0.1
Intermitt. access day 15 inactive lever presses	0.7	0.8	2.0	1.4	-0.1	-0.7
Intermitt. access escalation Index	0.2	0.2	0.3	-0.4	0.6	0.1
Intermittent access day 1 total infusions	1.1	1.2	3.2	1.8	-0.7	0.2
Intermittent access day 15 total infusions	1.7	1.9	4.1	2.0	-1.2	0.4
Intermittent access terminal intake (last 3 days)	1.0	1.1	1.9	1.4	-1.1	0.6
Intermittent access total infusions	1.9	2.1	4.2	2.0	-1.3	0.5
Intermittent access day 1 locomotion	1.9	2.0	5.3	2.3	-0.8	-0.4
Intermittent access day 15 total locomotion	1.1	1.2	1.7	1.2	-1.3	0.8
Intermittent access total locomotion	1.4	1.6	4.1	2.0	-0.8	-0.1
Intermittent access standard deviation	0.6	0.7	2.0	1.4	-0.2	0.0
Cocaine induced anxiety	3.5	4.0	6.1	-0.3	2.5	-2.4
Post-drug Anxiety	0.3	0.3	0.9	0.3	0.3	-0.9
Baseline Anxiety	1.9	2.0	3.3	1.3	-1.8	1.0
Lifetime Intake	1.4	1.6	3.6	1.9	-1.1	0.4
Incentive Sensitization - Responses	1.8	1.8	3.4	0.9	-1.8	1.1
Incentive Sensitization - Breakpoint	2.0	2.0	3.6	1.1	-1.9	1.0
Progressive ratio test 1 active lever presses	1.1	1.1	1.6	0.7	-1.1	1.3
Progressive ratio test 1 breakpoint	1.4	1.5	2.3	0.6	-1.3	1.5
Progressive ratio test 1 inactive lever presses	3.0	3.2	5.1	2.3	-1.8	1.0
Progressive ratio test 2 active lever presses	3.2	3.4	5.0	0.8	-2.2	2.1
Progressive ratio test 2 breakpoint	2.7	3.0	4.5	1.3	-2.1	1.7
Progressive ratio test 2 inactive lever presses	1.3	1.5	3.1	1.7	-1.1	0.3
Total sessions with >9 infusions	0.3	0.4	0.7	0.5	-0.8	0.5
Short access day 1 total inactive lever presses	2.7	3.0	8.1	2.9	-0.9	-0.2
Short access day 10 total inactive lever presses	0.6	0.7	1.1	1.1	-0.9	0.4
Short access day 1 total infusions	0.4	0.4	0.5	0.6	-0.7	0.7
Short access day 10 total infusions	1.3	1.5	3.4	1.8	0.4	-0.9
Short access total infusions	1.2	1.3	3.2	1.8	-0.8	0.1
Short access day 1 locomotion	1.0	1.0	1.9	0.5	1.0	-1.4
Short access day 10 total locomotion	0.6	0.6	1.1	0.8	0.1	-1.0
Short access total locomotion	1.3	1.3	2.5	1.6	-0.0	-1.2
Compulsive drug intake	1.2	1.2	1.7	1.0	0.9	-1.3
One hour access (0.3 mA shock)	0.5	0.5	1.5	1.2	-0.3	0.2
One hour access (shock baseline)	0.3	0.3	0.8	-0.1	-0.4	0.9
Number of responses in last shaping day	0.1	0.1	0.2	-0.4	0.3	-0.1
Context. condit. distance diff. score	4.8	5.8	8.9	-0.0	-3.0	2.9
Locomotion velocity, session 1	1.1	1.2	2.2	-1.0	1.5	-0.8
Locomotion distance, session 1	0.9	1.2	1.7	0.7	1.2	-1.3
Locomotion velocity, session 2	0.7	0.8	1.3	0.4	1.0	-1.1
Locomotion distance, session 2	2.5	3.6	5.1	1.1	2.1	-2.3
Locomotion velocity, session 3	0.6	0.7	1.1	-0.4	-0.9	1.0
Locomotion distance, session 3	1.1	1.2	1.9	0.2	-1.4	1.2
Stereotopy head waving bouts, day 3	0.6	0.7	1.3	-1.1	0.9	-0.2
Stereotopy head waving duration, day 3	1.0	1.2	2.2	-0.9	1.5	-0.8
Locomotion velocity, session 7	8.8	9.6	16.7	0.9	-4.1	3.4
Locomotion distance, session 7	5.6	7.1	11.9	0.4	-3.4	3.0
Stereotopy head waving bouts, day 7	0.9	1.0	1.5	0.5	1.1	-1.2
Stereotopy head waving duration, day 7	0.7	0.9	1.6	-0.2	1.2	-1.0
Locomotion velocity, session 8	0.4	0.5	0.7	0.4	-0.8	0.8
Locomotion distance, session 8	0.8	1.2	2.1	1.4	-1.1	0.5
Degree of sensitization distance	2.3	2.4	3.8	0.1	-1.9	1.8
Degree of sensitization stereotypy	0.5	0.5	0.6	0.7	0.6	-0.8
Condit. Reinf. active minus inactive responses	1.2	1.3	2.2	0.9	0.9	-1.5
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.5	-1.2	0.5	-0.1
Condit. Reinf. active responses	2.4	2.9	4.8	2.2	0.7	-1.9
Condit. Reinf. inactive responses	4.3	5.1	11.3	3.4	0.3	-2.0
Incentive salience index mean	3.3	4.0	5.8	2.4	0.8	-2.4
Condit. Reinf. lever presses	4.8	6.4	12.1	3.5	0.3	-2.7
Time in familiar zone, hab. session 1	0.6	0.6	1.1	0.8	-1.0	0.4
Time in novel zone, hab. session 1	2.2	2.2	4.9	-2.2	0.8	0.9
Total zone transitions, hab. session 1	0.5	0.6	1.2	-0.0	1.1	-0.9
Total locomotion distance, hab. session 1	1.1	1.6	2.7	0.7	1.3	-1.6
Locomotion velocity, hab. session 1	2.4	3.5	5.8	1.4	1.7	-2.4
Time in familiar zone, hab. session 2	1.1	1.1	2.1	-1.5	-0.1	1.1
Time in novel zone, hab. session 2	0.3	0.3	0.4	0.7	0.4	-0.6
Total zone transitions, hab. session 2	2.3	3.0	5.2	0.0	2.3	-2.0
Total locomotion distance, hab. session 2	1.5	2.0	3.1	0.4	1.8	-1.6
Locomotion velocity, hab. session 2	2.1	2.8	4.5	0.4	2.1	-1.9
Novel to familiar place preference ratio	1.3	1.3	3.6	1.9	-0.1	-0.6
Novelty place preference	1.4	1.5	3.9	2.0	-0.1	-0.6
Time in novel zone, NPP test	1.0	1.1	3.0	1.7	-0.0	-0.6
Total zone transitions, NPP test	0.9	1.4	1.8	1.1	1.0	-1.3
Total locomotion distance, NPP test	1.4	2.0	3.5	1.9	0.6	-1.4
Locomotion velocity, NPP test	1.5	2.2	4.4	2.1	0.5	-1.4
Pavlov. Cond. lever latency	2.0	2.5	6.0	-2.5	0.3	1.2
Pavlov. Cond. magazine entry latency	0.5	0.6	1.4	1.2	-0.7	-0.0
Pavlov. Cond. change in total contacts	1.5	1.6	3.2	1.8	0.3	-1.1
Pavlov. Cond. index score	1.7	2.2	5.4	2.3	-0.4	-1.0
Pavlov. Cond. latency score	2.1	2.7	6.7	2.6	-0.5	-1.1
Pavlov. Cond. lever contacts	2.1	2.5	5.8	2.4	-0.3	-1.2
Pavlov. Cond. magazine entry number	0.2	0.2	0.7	-0.8	0.3	0.1
Pavlov. Cond. intertrial magazine entries	1.2	1.4	2.2	1.3	0.5	-1.5
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.8	4.5	2.1	-0.2	-1.0
Pavlov. Cond. response bias	0.4	0.5	1.2	1.1	-0.2	-0.6
Bone: apparent density	0.2	0.3	0.8	0.9	-0.0	-0.4
Bone surface	0.4	0.6	0.9	0.9	0.4	-0.9
Bone volume	0.3	0.5	0.8	0.9	0.4	-0.7
Bone: connectivity density	0.4	0.6	1.4	1.2	-0.5	-0.3
Bone: cortical apparent density	1.8	2.3	3.7	-1.3	-1.2	1.9
Bone: cortical area	0.0	0.0	0.0	0.2	-0.1	-0.0
Bone: cortical porosity	2.4	2.6	4.1	1.6	1.0	-2.0
Bone: cortical porosity	1.9	2.0	3.4	1.3	1.0	-1.8
Bone: cortical thickness	0.2	0.3	0.7	0.8	-0.5	0.1
Bone: cortical thickness	0.8	0.9	1.5	0.3	-1.1	1.2
Bone: cortical tissue density	1.9	2.5	4.0	-1.4	-1.2	2.0
Bone: elastic displacement	1.0	1.2	1.5	0.7	1.2	-1.2
Bone: elastic work	2.3	3.0	4.4	1.2	1.7	-2.1
Bone: endosteal estimation	0.1	0.2	0.3	-0.4	0.5	-0.5
Bone: endosteal perimeter	0.3	0.5	0.6	-0.8	0.7	-0.7
Bone: final force	0.5	0.8	2.0	1.4	-0.6	-0.3
Bone: final moment	0.5	0.9	2.1	1.5	-0.2	-0.7
Bone: marrow area	0.1	0.2	0.3	-0.3	0.5	-0.6
Bone: maximum diameter	0.3	0.5	1.1	-1.0	-0.2	0.7
Bone: maximum force	0.4	0.6	1.2	1.1	0.2	-0.8
Bone: maximum moment	0.6	1.1	1.5	1.2	0.6	-1.2
Bone: minimum diameter	0.3	0.6	1.0	0.5	0.7	-1.0
Bone: periosteal estimation	0.0	0.1	0.1	-0.3	0.2	-0.2
Bone: periosteal perimeter	0.0	0.0	0.1	-0.4	0.0	0.0
Bone: post-yield work	0.9	1.2	2.1	0.5	-1.5	1.1
Bone: stiffness	0.3	0.4	1.0	1.0	-0.4	-0.3
Bone: tissue strength	0.4	0.4	0.8	0.5	0.3	-0.9
Bone: trabecular number	0.4	0.6	1.3	1.2	-0.6	-0.2
Bone: trabecular spacing	0.6	0.8	1.8	-1.4	0.8	-0.0
Bone: trabecular thickness	0.8	1.0	2.8	1.7	-0.4	-0.3
Bone: trabecular tissue density	0.6	0.9	1.9	-1.4	0.9	-0.0
Breakpoint value in progressive ratio session	0.2	0.2	0.4	-0.1	0.7	0.4
Distance traveled before self-admin	1.7	1.9	3.4	-1.0	1.9	-1.1
Distance traveled after self-admin	2.2	2.4	6.2	-2.5	0.4	1.0
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.3	-0.1	-0.3
Delta time in open arm before/after self-admin	0.1	0.1	0.1	0.2	-0.4	0.2
Diff in mean of infusions in LGA sessions	0.3	0.3	0.5	-0.3	0.6	0.7
Extinction: sum of active levers before priming	0.8	0.8	1.6	1.3	-0.7	0.3
Active lever presses in extinction session 6	0.7	0.7	0.9	0.8	-1.0	0.8
Delta distance traveled before/after self-admin	3.0	3.2	5.1	-1.8	-1.2	2.3
Delta ambulatory time before/after self-admin	1.5	1.6	2.6	-1.3	-0.8	1.6
Time in closed arm before self-admin	0.1	0.2	0.4	-0.6	-0.3	0.2
Time in closed arm after self-admin	0.1	0.2	0.4	-0.6	0.2	-0.1
Time in open arm before self-admin	0.2	0.2	0.3	-0.6	0.5	0.3
Time in open arm after self-admin	0.0	0.0	0.1	-0.3	0.0	0.2
Sum of active levers in priming session hrs 5-6	2.9	2.9	4.7	-1.8	-1.0	2.2
Time to tail flick, vehicle, before self-admin	2.2	2.2	5.6	2.4	-1.0	0.0
Time to tail flick, vehicle, after self-admin	1.1	1.2	2.8	-0.7	-0.5	1.7
Time to tail flick, test, before self-admin	0.4	0.4	0.7	0.7	0.2	-0.8
Time to tail flick, test, after self-admin	1.7	1.8	3.8	0.9	-1.9	0.9
Delta time to tail flick, vehicle, before/after SA	1.2	1.1	1.9	-1.2	-0.3	1.4
Delta time to tail flick, test, before/after SA	2.4	2.1	3.5	-0.3	-1.9	1.7
Ambulatory time before self-admin	0.8	0.9	1.9	-0.2	1.4	-0.9
Ambulatory time after self-admin	1.6	1.8	4.1	-2.0	1.1	0.3
Total heroin consumption	0.4	0.5	1.3	-0.2	1.1	-0.3
Area under the delay curve	0.5	0.5	0.8	0.7	0.5	-0.9
Delay disc. indifference point, 0s delay	1.3	1.4	2.6	-0.0	1.3	-1.6
Delay disc. indifference point, 16s delay	0.3	0.3	0.4	0.5	0.6	-0.6
Delay disc. indifference point, 2s delay	1.4	1.6	1.9	-1.4	1.4	-1.0
Delay disc. indifference point, 24s delay	0.0	0.0	0.0	-0.1	-0.1	0.2
Delay disc. indifference point, 4s delay	0.3	0.3	0.5	-0.7	0.6	-0.3
Delay disc. indifference point, 8s delay	0.6	0.6	1.5	1.2	-0.2	-0.5
Delay discount exponential model param	0.4	0.4	0.7	-0.6	-0.4	0.8
Delay discount hyperbolic model param	0.4	0.5	0.9	-0.2	-0.7	0.9
Fecal boli incidents, locomotor time 1	1.0	1.1	1.2	1.0	1.1	-1.0
Change in fecal boli incidents, locomotor task	0.7	0.7	1.9	-1.4	0.1	0.3
Time >=10cm from walls, locomotor time 1	0.5	0.5	0.8	0.8	0.2	-0.9
Bouts of movement, locomotor time 1	0.5	0.6	1.2	-1.1	0.2	0.7
Total resting periods, locomotor time 1	0.7	0.8	1.6	-1.3	0.1	0.9
Rest time, locomotor task time 1	1.1	1.2	2.4	-1.5	1.1	0.0
Distance moved, locomotor task time 1	0.7	0.7	1.3	1.0	-1.1	0.3
Vertical activity count, locomotor time 1	0.3	0.4	0.7	-0.2	0.8	-0.6
Time >=10cm from walls, locomotor time 2	1.0	1.1	1.7	-1.1	1.3	-0.6
Bouts of movement, locomotor time 2	0.5	0.6	0.9	-0.8	0.2	1.0
Total resting periods, locomotor time 2	0.4	0.4	0.9	-0.6	0.2	1.0
Rest time, locomotor task time 2	0.2	0.3	0.8	-0.3	-0.1	0.9
Distance moved, locomotor task time 2	0.6	0.6	1.2	1.1	-0.0	-0.9
Vertical activity count, locomotor time 2	1.1	1.2	2.1	-0.7	1.5	-0.9
Weight adjusted by age	1.3	1.4	1.8	-1.3	1.3	-0.9
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.5	-0.3	0.3	-0.7
Locomotion in novel chamber	0.9	1.1	1.5	1.2	0.7	-1.1
Locomotion in novel chamber post-restriction	0.2	0.3	0.4	-0.6	-0.2	0.6
Progressive ratio	0.9	1.0	2.4	-0.5	-0.7	1.5
Food seeking constrained by brief footshock	4.5	5.5	8.4	-2.9	-0.2	2.8
Seeking ratio, punishment vs. effort	0.5	0.6	1.6	-1.3	0.3	0.1
Run reversals in cocaine runway, females	0.5	0.5	0.9	-0.1	-1.0	0.7
Run reversals in cocaine runway, males	0.7	0.7	1.0	0.7	1.0	-0.7
Latency to leave start box in cocaine runway	1.1	1.2	1.7	-1.3	1.3	-0.4
Latency to leave start box in cocaine runway, F	0.5	0.6	1.2	-0.7	1.1	-0.4
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.3	0.3	-0.3
Cd content in liver	0.2	0.2	0.4	0.2	-0.6	0.5
Co content in liver	3.3	3.8	7.9	-2.8	0.0	1.9
Cu content in liver	0.7	0.9	1.9	-1.4	0.8	0.3
Fe content in liver	0.2	0.2	0.4	0.4	-0.6	0.1
K content in liver	0.6	0.6	1.4	0.5	-1.2	0.5
Mg content in liver	0.5	0.5	0.7	-0.4	-0.8	0.8
Mn content in liver	0.4	0.5	0.6	-0.6	-0.7	0.7
Na content in liver	5.2	5.5	9.7	0.6	2.5	-3.1
Rb content in liver	0.3	0.4	0.7	0.1	-0.8	0.7
Se content in liver	2.8	3.3	5.2	-0.3	2.3	-2.2
Sr content in liver	0.1	0.1	0.2	-0.4	0.4	-0.2
Zn content in liver	2.7	2.9	4.6	0.2	2.1	-2.1