Hub : Genes

Nabp1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	intron excision ratio	chr9:50126817:50127478	0.03	0.03	1.0e-03	0	0	-0	0	1.1e-01	7.8e-02	4.4e-01	2.5e-01
2	Adipose	intron excision ratio	chr9:50127371:50127478	0.03	0.02	2.8e-03	0	0.01	0.01	0	7.9e-02	2.9e-02	6.0e-02	1.7e-01
3	Brain	gene expression	ENSRNOG00000015416	0.04	0.03	1.1e-03	0.03	0.02	0	0.02	1.8e-03	8.5e-03	1.8e-01	1.2e-02
4	OFC	gene expression	ENSRNOG00000015416	0.27	0.16	2.9e-03	0.04	0.07	0.04	0.07	5.1e-02	8.5e-03	5.0e-02	1.1e-02
5	PL	gene expression	ENSRNOG00000015416	0.07	0.04	1.0e-05	0.07	0.07	0.05	0.07	6.1e-06	3.3e-06	1.0e-04	3.8e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
BMI with tail	5.7	18.4	24.3	4.4	-4.4	-4.9	-3.6	-4.0
BMI without tail	1.1	2.4	4.5	1.5	-1.5	-2.1	-1.2	-1.2
Body weight	0.1	0.6	1.2	-0.5	0.4	0.4	1.1	1.1
Epididymis fat weight	0.5	1.2	1.8	-1.3	1.4	0.7	0.7	1.1
Glucose	0.2	0.3	0.6	0.6	-0.7	-0.3	0.7	0.2
Heart weight	0.2	0.3	0.5	-0.7	0.7	-0.4	0.4	0.3
Left kidney weight	0.3	0.8	1.2	-0.8	0.7	0.6	1.1	1.1
Right kidney weight	0.1	0.2	0.5	0.3	-0.3	-0.7	-0.5	-0.4
Tail length	5.8	17.6	22.9	-4.2	4.1	4.8	3.6	4.1
Length with tail	6.4	23.4	29.7	-4.7	4.6	5.4	4.5	4.9
Length without tail	0.6	1.3	2.0	-1.0	0.9	1.4	1.2	1.2
Liver weight, left	0.1	0.1	0.4	-0.2	0.3	-0.4	-0.6	-0.2
Liver weight, right	0.0	0.0	0.0	-0.1	0.0	-0.0	0.2	0.1
Parametrial fat weight	0.0	0.0	0.1	-0.0	0.0	-0.1	0.3	0.1
Retroperitoneal fat weight	0.1	0.2	0.4	0.4	-0.3	-0.5	-0.6	-0.5
Intraocular pressure	0.4	0.5	1.0	0.7	-0.9	-1.0	0.1	-0.5
Extensor digitorum longus weight	2.2	8.7	13.5	3.5	-3.7	-3.1	-1.6	-2.5
Soleus weight	0.3	1.0	1.3	1.0	-1.1	-1.1	-0.5	-1.0
Tibialis anterior weight	1.2	4.2	6.6	2.5	-2.6	-2.2	-1.1	-1.6
Tibia length	3.7	10.3	13.3	-3.6	3.6	2.9	2.7	3.1
Number of licking bursts	0.2	0.3	0.7	-0.2	0.1	0.1	0.9	0.8
Food consumed during 24 hour testing period	0.2	0.2	0.5	-0.7	0.7	-0.1	0.2	0.2
Times rat made contact with spout	1.5	1.7	2.7	-0.7	0.6	1.6	1.6	1.6
Mean time between licks in bursts	0.7	0.9	2.1	1.3	-1.4	-0.6	-0.2	-0.7
Mean num. licks in bursts	0.1	0.1	0.2	0.1	-0.1	0.5	-0.4	-0.4
Std. dev. time between licks in bursts	2.8	3.4	6.3	2.4	-2.5	-1.0	-1.2	-1.5
Water consumed over 24 hours	0.2	0.2	0.3	0.5	-0.6	-0.5	-0.2	-0.2
Indifference point 0 sec	8.2	13.2	18.0	3.3	-3.0	-3.4	-4.2	-4.1
Indifference point AUC	0.8	1.0	1.3	0.9	-0.8	-1.1	-1.0	-1.1
Indifference point function ln k	1.8	2.6	3.9	1.4	-1.2	-1.5	-2.0	-1.8
Indifference point function log k	1.8	2.6	3.9	1.4	-1.2	-1.5	-2.0	-1.8
Delay discounting total patch changes 0 sec	7.9	12.8	16.9	3.3	-3.0	-3.4	-4.1	-4.0
Delay discounting total patch changes 12 sec	2.1	2.8	3.7	1.4	-1.3	-1.8	-1.9	-1.9
Delay discounting total patch changes 18 sec	4.1	5.4	6.5	2.3	-2.2	-2.4	-2.2	-2.5
Delay discounting total patch changes 24 sec	2.6	3.3	4.9	1.7	-1.5	-1.3	-2.2	-2.1
Delay discounting total patch changes 6 sec	6.4	9.8	12.6	3.0	-2.8	-2.8	-3.6	-3.4
Delay discounting time to switch 0 sec	2.3	3.5	5.6	-1.5	1.3	2.1	2.4	1.9
Delay discounting water rate 0 sec	1.5	2.3	3.4	1.3	-1.2	-1.8	-1.7	-1.6
Delay discounting water rate 12 sec	1.6	2.4	3.7	1.1	-1.0	-1.7	-1.9	-1.8
Delay discounting water rate 18 sec	0.1	0.1	0.3	-0.2	0.2	-0.5	-0.0	0.1
Delay discounting water rate 24 sec	0.3	0.4	0.6	-0.6	0.6	-0.0	0.8	0.7
Delay discounting water rate 6 sec	1.0	1.5	2.3	1.2	-1.1	-1.0	-1.5	-1.3
Locomotor activity	0.2	0.4	1.4	0.1	-0.0	-1.2	-0.6	-0.3
Locomotor testing distance	0.7	1.2	3.3	0.3	-0.1	-1.8	-1.3	-1.0
Locomotor testing rearing	0.3	0.5	1.7	0.5	-0.5	-1.3	-0.4	-0.3
Light reinforcement 1	1.6	3.0	5.3	2.2	-2.3	-1.5	-1.0	-1.2
Light reinforcement 2	0.1	0.1	0.3	0.6	-0.5	0.0	-0.3	-0.1
Reaction time number correct	0.6	0.8	2.0	0.7	-1.0	0.2	1.4	0.7
Reaction time mean minus median	2.0	2.7	4.1	-2.0	2.0	1.4	1.1	1.4
Reaction time mean minus median AUC	1.8	2.3	3.3	-1.8	1.8	1.3	1.1	1.4
Reaction time num false alarms	2.9	4.0	5.6	2.4	-2.4	-1.8	-1.5	-1.8
Reaction time num false alarms AUC	2.6	3.6	5.4	2.3	-2.3	-1.7	-1.3	-1.6
Reaction time trials correct on left	0.6	0.8	2.0	0.7	-1.0	0.2	1.4	0.7
Reaction time trials on left	0.6	0.9	2.5	0.6	-0.9	0.3	1.6	0.9
Reaction time mean	8.2	11.2	13.8	-3.7	3.7	3.1	2.9	3.3
Reaction time mean AUC	8.0	10.7	12.8	-3.6	3.5	2.9	2.9	3.3
Median of all reaction times	8.2	11.1	13.2	-3.6	3.6	3.1	2.9	3.3
Reaction time omissions	1.3	1.8	2.3	-1.2	1.1	1.4	1.5	1.5
Reaction time false alarm rate	2.3	3.3	4.1	1.8	-1.6	-1.6	-2.0	-1.9
Reaction time premature initiation rate	0.9	1.2	3.2	0.3	-0.1	-1.8	-1.2	-0.9
Reaction time premature initiations	0.5	0.7	2.3	0.6	-0.7	-1.5	-0.3	-0.5
Std. dev. reaction times	5.1	7.0	10.4	-3.2	3.2	2.3	1.9	2.4
Reaction time trials completed	0.6	0.9	2.5	0.6	-0.9	0.3	1.6	0.9
Reaction time trials AUC	0.6	0.8	2.1	0.7	-1.0	0.3	1.5	0.7
Social response proportion	0.8	0.9	1.8	-1.3	1.4	0.7	0.4	0.7
Social responses	0.1	0.1	0.4	-0.3	0.4	-0.6	-0.3	-0.0
Social time	1.0	1.3	1.5	-1.2	1.2	1.2	0.9	1.1
Conditioned locomotion	2.1	2.5	3.6	-1.2	1.1	1.6	1.9	1.9
Cocaine response after cond. corrected	0.1	0.1	0.1	-0.4	0.4	0.1	0.2	0.3
Cocaine response after cond. not corrected	1.0	1.1	1.6	-1.3	1.2	0.5	1.1	1.1
Cocaine response before conditioning	0.9	1.1	1.4	-1.1	1.1	0.4	1.2	1.2
Saline control response	0.1	0.1	0.3	0.1	-0.2	-0.6	0.4	0.3
Condit. Reinf. active minus inactive responses	2.8	3.5	5.4	-2.3	2.3	1.5	1.3	1.7
Condit. Reinf. active-inactive response ratio	2.4	2.5	4.2	-2.0	2.0	1.1	1.0	1.5
Condit. Reinf. active responses	0.4	0.6	1.2	-1.1	1.1	0.1	0.5	0.6
Condit. Reinf. inactive responses	1.0	1.3	2.9	0.6	-0.6	-1.7	-1.0	-1.3
Condit. Reinf. lever presses	0.6	0.9	2.2	0.3	-0.2	-1.5	-1.1	-0.9
Condit. Reinf. lever reinforcers received	0.3	0.4	1.0	-0.9	1.0	-0.2	0.2	0.3
Pavlov. Cond. lever latency	0.6	0.8	1.6	-0.2	0.1	1.1	1.3	1.1
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	-0.1	0.2	-0.2	-0.1	-0.1
Pavlov. Cond. change in total contacts	0.3	0.4	1.2	-0.3	0.5	-0.4	-1.1	-0.7
Pavlov. Cond. index score	0.3	0.3	0.7	-0.1	0.2	-0.6	-0.8	-0.7
Pavlov. Cond. latency score	0.1	0.2	0.4	-0.2	0.3	-0.4	-0.6	-0.5
Pavlov. Cond. lever contacts	0.6	0.8	1.8	0.0	0.2	-1.1	-1.3	-1.1
Pavlov. Cond. magazine entry number	0.2	0.2	0.4	0.6	-0.7	-0.2	-0.2	-0.3
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.5	0.6	-0.7	-0.2	0.5	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.7	0.1	0.0	-0.6	-0.8	-0.7
Pavlov. Cond. response bias	0.2	0.3	0.4	-0.4	0.6	-0.6	-0.7	-0.4
Conditioned reinforcement - actives	0.9	0.9	1.1	-0.8	0.8	0.9	1.1	1.0
Conditioned reinforcement - inactives	3.0	3.4	5.4	-1.6	1.4	1.6	2.3	2.2
Conditioned locomotion	0.8	1.0	1.8	1.2	-1.3	-1.2	-0.2	-0.6
Intermittent access intake day 1-15 change	0.5	0.5	0.8	0.9	-0.9	-0.7	-0.4	-0.6
Intermittent access intake escalation	0.4	0.4	0.5	0.6	-0.6	-0.7	-0.5	-0.6
Intermittent access intake escalation 2	0.2	0.2	0.3	0.3	-0.2	-0.4	-0.6	-0.5
Intermitt. access day 1 inactive lever presses	1.3	1.4	3.5	-0.4	0.1	1.0	1.9	1.5
Intermitt. access day 15 inactive lever presses	0.7	0.7	1.1	-1.0	1.1	0.4	0.7	0.9
Intermitt. access escalation Index	0.4	0.3	1.0	0.2	-0.4	0.3	1.0	0.6
Intermittent access day 1 total infusions	0.4	0.4	0.7	-0.5	0.4	0.8	0.7	0.7
Intermittent access day 15 total infusions	0.2	0.3	0.6	0.2	-0.3	0.5	0.7	0.6
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.4	0.5	-0.6	0.3	0.2	0.1
Intermittent access total infusions	0.6	0.7	1.2	-0.3	0.2	1.1	1.0	1.0
Intermittent access day 1 locomotion	0.2	0.2	0.3	0.4	-0.4	-0.5	-0.4	-0.5
Intermittent access day 15 total locomotion	0.1	0.1	0.4	0.1	-0.1	-0.7	-0.2	-0.3
Intermittent access total locomotion	0.3	0.3	0.6	0.6	-0.6	-0.8	-0.2	-0.3
Intermittent access standard deviation	0.1	0.1	0.3	0.4	-0.5	-0.2	0.5	0.2
Cocaine induced anxiety	1.7	2.0	3.2	1.7	-1.8	-1.4	-0.9	-1.1
Post-drug Anxiety	0.2	0.2	0.5	0.6	-0.7	-0.3	0.3	0.2
Baseline Anxiety	2.8	2.9	3.3	-1.8	1.8	1.8	1.6	1.7
Lifetime Intake	0.3	0.4	0.8	0.0	-0.1	0.9	0.8	0.7
Incentive Sensitization - Responses	2.0	2.0	2.9	-1.1	1.0	1.3	1.7	1.7
Incentive Sensitization - Breakpoint	2.0	2.1	3.2	-1.1	1.0	1.3	1.8	1.8
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	0.3	-0.4	0.2	0.2	0.1
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	0.4	-0.5	-0.0	0.0	-0.2
Progressive ratio test 1 inactive lever presses	0.5	0.5	1.7	0.1	-0.3	0.4	1.3	0.8
Progressive ratio test 2 active lever presses	1.1	1.2	1.9	-0.6	0.5	1.2	1.4	1.3
Progressive ratio test 2 breakpoint	0.4	0.5	0.8	-0.2	0.1	0.9	0.9	0.9
Progressive ratio test 2 inactive lever presses	1.7	2.0	3.6	-0.9	0.8	1.3	1.9	1.8
Total sessions with >9 infusions	0.5	0.5	1.0	0.9	-1.0	-0.7	-0.1	-0.5
Short access day 1 total inactive lever presses	0.7	0.8	1.6	-0.5	0.3	0.8	1.3	1.2
Short access day 10 total inactive lever presses	2.0	2.2	3.8	-1.3	1.2	1.1	1.9	1.8
Short access day 1 total infusions	0.1	0.1	0.2	0.2	-0.3	0.0	0.5	0.1
Short access day 10 total infusions	0.3	0.3	0.6	0.0	-0.1	0.8	0.7	0.7
Short access total infusions	0.2	0.2	0.5	0.6	-0.7	0.0	-0.0	-0.2
Short access day 1 locomotion	0.1	0.1	0.3	0.3	-0.5	0.1	0.5	0.1
Short access day 10 total locomotion	0.8	0.9	1.9	0.4	-0.2	-1.4	-1.2	-1.1
Short access total locomotion	0.2	0.2	0.3	0.4	-0.6	-0.5	0.5	0.1
Compulsive drug intake	0.5	0.5	1.0	0.3	-0.2	-0.8	-1.0	-0.7
One hour access (0.3 mA shock)	0.1	0.1	0.2	-0.2	0.3	0.5	-0.3	0.1
One hour access (shock baseline)	1.0	1.2	2.1	-0.7	0.6	1.5	1.2	1.2
Number of responses in last shaping day	0.2	0.2	0.5	0.6	-0.7	-0.2	0.5	0.2
Context. condit. distance diff. score	1.7	2.1	4.1	1.2	-1.2	-2.0	-1.2	-1.4
Locomotion velocity, session 1	1.4	1.5	2.6	1.1	-1.0	-1.1	-1.3	-1.6
Locomotion distance, session 1	1.1	1.4	2.5	1.0	-1.0	-1.0	-1.3	-1.6
Locomotion velocity, session 2	3.3	3.8	4.6	2.1	-2.1	-1.8	-1.6	-2.0
Locomotion distance, session 2	0.3	0.4	0.9	0.8	-0.9	0.1	-0.2	-0.6
Locomotion velocity, session 3	1.0	1.1	1.8	-0.5	0.4	1.3	1.3	1.3
Locomotion distance, session 3	0.3	0.3	0.7	0.0	-0.1	0.9	0.6	0.6
Stereotopy head waving bouts, day 3	0.2	0.3	0.7	0.3	-0.5	0.0	0.8	0.6
Stereotopy head waving duration, day 3	0.3	0.4	1.1	-0.1	-0.0	0.5	1.1	0.8
Locomotion velocity, session 7	1.9	2.0	3.7	0.9	-0.9	-1.9	-1.4	-1.7
Locomotion distance, session 7	1.3	1.6	2.3	1.0	-1.0	-1.5	-1.2	-1.5
Stereotopy head waving bouts, day 7	0.8	0.9	1.5	-0.8	0.7	0.7	1.2	1.1
Stereotopy head waving duration, day 7	1.5	1.9	2.5	-1.4	1.3	1.0	1.6	1.6
Locomotion velocity, session 8	1.5	1.9	2.5	1.0	-0.9	-1.5	-1.6	-1.6
Locomotion distance, session 8	2.3	3.5	4.5	1.6	-1.6	-2.1	-1.8	-2.1
Degree of sensitization distance	0.9	0.9	2.1	0.4	-0.3	-1.4	-1.0	-1.2
Degree of sensitization stereotypy	0.2	0.2	0.3	-0.5	0.5	0.3	0.3	0.4
Condit. Reinf. active minus inactive responses	6.1	6.9	8.0	-2.8	2.8	2.4	2.3	2.7
Condit. Reinf. active-inactive response ratio	3.9	4.2	4.6	-2.1	2.1	1.9	1.9	2.1
Condit. Reinf. active responses	3.3	4.1	6.4	-2.4	2.5	1.7	1.3	1.9
Condit. Reinf. inactive responses	0.3	0.3	0.8	0.0	0.1	-0.6	-0.9	-0.6
Incentive salience index mean	2.2	2.6	4.8	-2.0	2.2	1.4	0.7	1.4
Condit. Reinf. lever presses	0.4	0.5	1.7	-0.3	0.6	0.1	-1.3	-0.7
Time in familiar zone, hab. session 1	0.5	0.5	1.0	0.8	-0.8	-1.0	-0.3	-0.4
Time in novel zone, hab. session 1	2.5	2.4	4.2	-1.9	2.0	1.4	0.8	1.3
Total zone transitions, hab. session 1	0.2	0.2	0.6	-0.2	0.4	-0.4	-0.8	-0.5
Total locomotion distance, hab. session 1	0.4	0.6	1.5	-1.1	1.2	0.3	0.2	0.4
Locomotion velocity, hab. session 1	0.2	0.2	0.5	-0.6	0.7	0.4	0.1	0.3
Time in familiar zone, hab. session 2	0.1	0.1	0.2	-0.3	0.3	-0.5	0.1	0.2
Time in novel zone, hab. session 2	0.3	0.3	0.7	-0.1	0.0	0.8	0.7	0.5
Total zone transitions, hab. session 2	0.2	0.2	0.5	0.4	-0.3	0.0	-0.5	-0.7
Total locomotion distance, hab. session 2	0.8	1.0	1.3	-1.0	1.0	1.1	1.0	0.9
Locomotion velocity, hab. session 2	0.4	0.6	0.8	-0.8	0.7	0.9	0.8	0.6
Novel to familiar place preference ratio	3.5	3.7	6.5	-1.6	1.5	2.6	1.9	2.0
Novelty place preference	3.5	3.7	6.3	-1.4	1.3	2.5	2.0	2.0
Time in novel zone, NPP test	4.3	4.6	7.5	-1.6	1.5	2.7	2.2	2.3
Total zone transitions, NPP test	0.6	0.9	1.4	0.9	-0.9	-0.7	-0.9	-1.2
Total locomotion distance, NPP test	0.0	0.1	0.1	-0.3	0.4	-0.1	-0.1	-0.2
Locomotion velocity, NPP test	0.1	0.1	0.2	0.1	-0.0	-0.4	-0.4	-0.5
Pavlov. Cond. lever latency	0.6	0.8	1.7	1.0	-1.3	0.2	0.9	0.4
Pavlov. Cond. magazine entry latency	0.7	0.9	2.4	-1.4	1.6	0.2	-0.3	-0.0
Pavlov. Cond. change in total contacts	0.4	0.5	0.9	-0.7	0.9	0.1	-0.8	-0.6
Pavlov. Cond. index score	0.5	0.7	1.6	-1.0	1.3	0.1	-0.7	-0.3
Pavlov. Cond. latency score	0.6	0.8	1.9	-1.1	1.4	-0.2	-0.8	-0.4
Pavlov. Cond. lever contacts	0.3	0.4	0.8	-0.5	0.7	-0.2	-0.9	-0.5
Pavlov. Cond. magazine entry number	1.5	1.9	4.3	1.9	-2.1	-1.0	-0.3	-0.6
Pavlov. Cond. intertrial magazine entries	1.9	2.2	3.9	-0.7	0.5	1.7	1.9	2.0
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.2	-0.9	1.1	-0.0	-0.7	-0.4
Pavlov. Cond. response bias	0.4	0.5	1.3	-1.0	1.1	0.4	-0.4	-0.1
Bone: apparent density	0.9	1.6	2.8	-1.5	1.7	1.3	0.5	0.9
Bone surface	0.4	0.6	1.1	-0.8	1.0	1.1	-0.0	0.5
Bone volume	1.0	1.8	3.3	-1.6	1.8	1.4	0.4	1.0
Bone: connectivity density	0.1	0.1	0.2	-0.1	0.2	0.4	-0.4	-0.2
Bone: cortical apparent density	6.9	9.0	13.0	3.4	-3.6	-3.2	-1.8	-2.6
Bone: cortical area	0.1	0.2	0.3	-0.2	0.2	0.5	0.6	0.5
Bone: cortical porosity	3.1	3.4	4.2	-1.9	2.0	2.1	1.2	1.8
Bone: cortical porosity	3.5	3.8	5.3	-2.1	2.3	2.1	1.1	1.9
Bone: cortical thickness	0.7	1.2	2.5	1.4	-1.6	-0.8	-0.4	-0.8
Bone: cortical thickness	0.2	0.2	0.5	0.2	-0.2	-0.7	-0.3	-0.4
Bone: cortical tissue density	6.9	8.9	12.8	3.4	-3.6	-3.2	-1.8	-2.6
Bone: elastic displacement	0.2	0.2	0.4	-0.3	0.2	0.2	0.6	0.6
Bone: elastic work	1.3	1.7	2.1	-1.5	1.5	1.1	1.2	1.3
Bone: endosteal estimation	3.1	6.8	11.1	-3.1	3.3	2.5	1.4	2.2
Bone: endosteal perimeter	2.5	5.2	6.3	-2.5	2.5	2.2	1.8	2.4
Bone: final force	2.2	3.6	4.6	-1.8	1.7	2.1	1.8	2.0
Bone: final moment	1.5	2.5	3.5	-1.4	1.4	1.9	1.5	1.7
Bone: marrow area	3.0	6.4	10.5	-3.0	3.2	2.3	1.4	2.2
Bone: maximum diameter	0.3	0.6	1.1	-0.6	0.6	0.8	0.9	1.0
Bone: maximum force	2.1	3.7	4.4	-2.0	2.0	2.1	1.6	1.8
Bone: maximum moment	1.5	2.6	3.4	-1.6	1.6	1.8	1.3	1.5
Bone: minimum diameter	0.8	1.5	1.9	-1.3	1.4	1.3	0.8	1.2
Bone: periosteal estimation	2.2	4.5	6.2	-2.4	2.5	2.1	1.5	2.0
Bone: periosteal perimeter	1.9	3.2	3.8	-1.8	1.8	1.7	1.7	2.0
Bone: post-yield work	1.2	1.6	2.0	-1.4	1.4	1.3	0.9	1.2
Bone: stiffness	1.1	1.7	2.3	-1.5	1.5	1.5	0.9	1.1
Bone: tissue strength	0.5	0.4	1.4	-0.2	0.1	1.2	0.6	0.6
Bone: trabecular number	0.3	0.4	0.9	-0.8	1.0	0.8	-0.1	0.3
Bone: trabecular spacing	0.4	0.5	1.1	0.3	-0.2	-1.1	-0.8	-0.8
Bone: trabecular thickness	0.5	0.6	1.3	-1.0	1.1	0.9	0.1	0.3
Bone: trabecular tissue density	0.1	0.1	0.2	-0.3	0.2	-0.3	0.4	0.1
Breakpoint value in progressive ratio session	0.7	0.7	1.0	-1.0	1.0	0.1	0.9	0.9
Distance traveled before self-admin	4.6	4.9	7.5	-2.7	2.7	1.8	1.6	2.0
Distance traveled after self-admin	0.7	0.7	2.0	-1.3	1.4	-0.0	-0.0	0.4
Delta time in closed arm before/after self-admin	0.3	0.3	0.4	0.7	-0.6	0.5	-0.5	-0.2
Delta time in open arm before/after self-admin	2.6	2.5	3.9	-1.8	1.9	2.0	0.9	1.0
Diff in mean of infusions in LGA sessions	1.1	1.2	1.9	-1.3	1.4	0.7	0.8	1.1
Extinction: sum of active levers before priming	1.3	1.3	2.1	-1.4	1.4	0.5	1.0	1.1
Active lever presses in extinction session 6	0.2	0.2	0.4	-0.7	0.7	0.1	0.3	0.4
Delta distance traveled before/after self-admin	1.0	1.0	1.4	1.0	-1.0	-1.2	-0.8	-1.0
Delta ambulatory time before/after self-admin	1.8	1.9	2.5	1.3	-1.2	-1.6	-1.4	-1.5
Time in closed arm before self-admin	1.2	1.3	2.8	-1.6	1.7	0.9	0.3	0.6
Time in closed arm after self-admin	0.6	0.6	2.2	-0.0	0.3	0.0	-1.5	-0.9
Time in open arm before self-admin	1.0	1.0	2.4	1.3	-1.5	-0.9	0.7	0.1
Time in open arm after self-admin	2.5	2.8	3.1	-1.8	1.7	1.7	1.6	1.6
Sum of active levers in priming session hrs 5-6	1.9	1.8	2.8	-1.7	1.6	0.8	1.3	1.2
Time to tail flick, vehicle, before self-admin	0.9	1.0	1.0	1.0	-0.9	-0.9	-1.0	-1.0
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	-0.1	0.2	-0.2	-0.3	-0.2
Time to tail flick, test, before self-admin	0.2	0.2	0.4	0.5	-0.7	-0.1	0.4	0.3
Time to tail flick, test, after self-admin	1.7	1.7	2.3	1.5	-1.5	-1.1	-1.1	-1.3
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	0.8	-0.9	0.9	0.8	0.8	0.8
Delta time to tail flick, test, before/after SA	1.5	1.3	2.4	0.8	-0.7	-0.8	-1.5	-1.5
Ambulatory time before self-admin	4.6	4.8	6.4	-2.5	2.5	1.7	1.9	2.2
Ambulatory time after self-admin	0.6	0.6	1.2	-0.1	0.3	-1.1	-1.0	-0.8
Total heroin consumption	0.4	0.5	0.9	-0.9	1.0	0.3	0.4	0.6
Area under the delay curve	3.0	3.2	5.9	1.1	-0.8	-1.9	-2.4	-2.1
Delay disc. indifference point, 0s delay	2.9	3.1	5.0	1.1	-0.8	-2.2	-2.2	-2.1
Delay disc. indifference point, 16s delay	1.9	1.9	4.0	0.4	-0.1	-1.6	-2.0	-1.6
Delay disc. indifference point, 2s delay	1.5	1.7	2.8	0.8	-0.6	-1.7	-1.6	-1.5
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.3	-0.3	-0.4	-0.4	-0.3
Delay disc. indifference point, 4s delay	1.7	1.8	2.1	1.3	-1.1	-1.4	-1.5	-1.4
Delay disc. indifference point, 8s delay	1.8	1.9	4.4	0.4	-0.1	-1.5	-2.1	-1.7
Delay discount exponential model param	2.5	2.7	5.0	-1.0	0.8	1.8	2.2	1.9
Delay discount hyperbolic model param	2.9	3.1	5.4	-1.2	0.9	1.9	2.3	2.1
Fecal boli incidents, locomotor time 1	5.1	5.5	12.0	1.4	-1.1	-1.9	-3.5	-3.0
Change in fecal boli incidents, locomotor task	0.5	0.4	0.6	-0.5	0.4	0.8	0.8	0.8
Time >=10cm from walls, locomotor time 1	0.4	0.4	1.2	0.4	-0.2	0.1	-1.1	-0.8
Bouts of movement, locomotor time 1	3.7	4.0	5.1	1.9	-1.8	-1.8	-2.3	-2.3
Total resting periods, locomotor time 1	4.3	4.8	5.9	2.1	-1.9	-2.0	-2.4	-2.4
Rest time, locomotor task time 1	1.0	1.1	1.6	1.1	-1.0	-0.6	-1.3	-1.2
Distance moved, locomotor task time 1	0.5	0.5	0.9	-0.7	0.6	0.9	0.7	0.6
Vertical activity count, locomotor time 1	0.6	0.6	1.3	-0.6	0.5	0.4	1.1	0.9
Time >=10cm from walls, locomotor time 2	1.0	1.1	1.9	-1.3	1.4	1.2	0.3	0.7
Bouts of movement, locomotor time 2	3.6	3.9	4.8	2.1	-2.2	-2.1	-1.5	-1.8
Total resting periods, locomotor time 2	4.5	4.8	5.7	2.3	-2.4	-2.3	-1.7	-2.1
Rest time, locomotor task time 2	0.6	0.7	1.5	1.2	-1.2	-0.4	-0.4	-0.5
Distance moved, locomotor task time 2	0.2	0.3	0.6	-0.7	0.8	0.4	0.1	0.1
Vertical activity count, locomotor time 2	0.1	0.1	0.2	-0.2	0.1	-0.1	0.5	0.3
Weight adjusted by age	0.1	0.1	0.3	-0.2	0.3	-0.2	-0.5	-0.4
Seeking ratio, delayed vs. immediate footshock	1.9	2.1	2.6	-1.6	1.5	1.6	1.2	1.3
Locomotion in novel chamber	0.6	0.8	2.1	0.8	-1.0	-1.4	0.0	-0.5
Locomotion in novel chamber post-restriction	0.2	0.2	0.4	0.3	-0.5	0.3	0.6	0.4
Progressive ratio	0.2	0.3	0.9	0.0	-0.1	0.9	0.6	0.5
Food seeking constrained by brief footshock	0.9	1.1	3.9	-0.5	0.5	2.0	0.6	0.8
Seeking ratio, punishment vs. effort	0.1	0.1	0.1	-0.2	0.2	-0.3	-0.4	-0.2
Run reversals in cocaine runway, females	0.7	0.7	1.5	-0.4	0.2	0.9	1.2	1.1
Run reversals in cocaine runway, males	0.2	0.1	0.2	0.4	-0.4	-0.4	-0.4	-0.2
Latency to leave start box in cocaine runway	5.5	6.1	8.2	2.8	-2.9	-2.3	-1.9	-2.3
Latency to leave start box in cocaine runway, F	2.1	2.3	3.3	1.8	-1.8	-1.6	-1.1	-1.1
Latency to leave start box in cocaine runway, M	4.5	4.4	5.9	2.2	-2.2	-1.7	-1.9	-2.4
Cd content in liver	0.2	0.2	0.4	-0.5	0.4	0.7	0.4	0.2
Co content in liver	0.7	0.9	2.2	0.4	-0.2	-0.6	-1.5	-1.2
Cu content in liver	0.3	0.3	0.8	-0.8	0.9	0.4	-0.0	0.3
Fe content in liver	3.7	4.4	5.0	-2.2	2.2	2.2	1.7	2.1
K content in liver	0.8	0.8	1.2	1.1	-1.0	-0.0	-1.1	-1.0
Mg content in liver	0.2	0.2	0.5	0.3	-0.4	0.7	0.4	0.3
Mn content in liver	0.3	0.4	1.1	0.5	-0.6	-1.1	-0.1	-0.4
Na content in liver	1.3	1.4	3.1	1.0	-0.8	-0.7	-1.8	-1.4
Rb content in liver	0.2	0.2	0.5	0.7	-0.7	-0.2	-0.0	-0.2
Se content in liver	0.4	0.4	1.0	-0.5	0.3	0.4	1.0	0.8
Sr content in liver	0.2	0.2	0.4	0.6	-0.6	0.6	0.1	-0.1
Zn content in liver	0.2	0.2	0.4	0.6	-0.6	-0.5	-0.3	-0.3