Hub : Genes

Lrrc32

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000015310 0.04 0.03 1.7e-03 0.03 0.02 0.03 0.02 7.6e-04 1.8e-03 3.0e-04 1.3e-03
2 Eye isoform ratio ENSRNOT00000020520 0.94 0.03 2.3e-03 -0.02 0.02 0.02 0.03 8.5e-01 1.5e-01 1.5e-01 1.3e-01
3 Liver gene expression ENSRNOG00000015310 0.05 0.06 3.1e-03 0.02 0.01 0.01 0.01 5.4e-03 3.1e-02 2.1e-02 2.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail0.51.52.6-1.40.4-1.6
BMI without tail3.67.68.9-2.63.0-2.6
Body weight0.93.64.6-2.11.4-2.1
Epididymis fat weight2.55.88.2-2.91.5-2.6
Glucose0.00.10.10.30.20.3
Heart weight0.60.91.21.0-0.71.1
Left kidney weight0.10.30.6-0.80.5-0.3
Right kidney weight0.10.30.4-0.60.7-0.3
Tail length1.34.07.5-1.82.7-1.1
Length with tail0.72.43.1-1.61.8-1.3
Length without tail0.20.51.40.3-1.2-0.0
Liver weight, left0.60.91.0-0.91.0-0.9
Liver weight, right2.84.76.3-2.31.6-2.5
Parametrial fat weight0.71.42.2-0.91.5-1.2
Retroperitoneal fat weight7.524.731.0-5.43.8-5.6
Intraocular pressure0.50.71.30.6-0.61.1
Extensor digitorum longus weight0.62.43.8-2.01.3-1.2
Soleus weight1.33.85.0-2.21.6-1.9
Tibialis anterior weight0.00.10.1-0.4-0.10.0
Tibia length1.64.44.92.0-2.22.1
Number of licking bursts2.73.24.4-2.01.1-2.1
Food consumed during 24 hour testing period2.32.74.11.8-0.82.0
Times rat made contact with spout1.31.52.5-1.01.6-1.0
Mean time between licks in bursts0.30.40.90.4-0.40.9
Mean num. licks in bursts1.61.92.81.6-0.61.7
Std. dev. time between licks in bursts0.40.51.2-0.41.1-0.3
Water consumed over 24 hours1.01.21.7-0.81.3-1.0
Indifference point 0 sec3.65.86.32.5-2.22.5
Indifference point AUC0.10.10.2-0.4-0.2-0.3
Indifference point function ln k2.12.93.61.9-1.31.9
Indifference point function log k2.12.93.61.9-1.31.9
Delay discounting total patch changes 0 sec3.15.15.42.3-2.12.3
Delay discounting total patch changes 12 sec0.10.10.30.1-0.60.2
Delay discounting total patch changes 18 sec0.10.20.40.3-0.10.6
Delay discounting total patch changes 24 sec0.00.00.00.1-0.00.2
Delay discounting total patch changes 6 sec1.42.23.21.3-1.81.2
Delay discounting time to switch 0 sec2.03.03.7-1.71.6-1.9
Delay discounting water rate 0 sec1.93.04.41.8-1.12.1
Delay discounting water rate 12 sec1.52.33.61.7-0.71.9
Delay discounting water rate 18 sec0.20.20.40.40.00.7
Delay discounting water rate 24 sec0.81.11.91.2-0.31.4
Delay discounting water rate 6 sec0.81.21.71.2-0.81.3
Locomotor activity0.20.30.50.70.30.5
Locomotor testing distance0.20.30.50.5-0.40.7
Locomotor testing rearing0.20.30.4-0.50.5-0.6
Light reinforcement 11.01.82.8-1.40.8-1.7
Light reinforcement 20.70.91.90.8-1.40.5
Reaction time number correct0.81.21.81.3-0.71.1
Reaction time mean minus median0.20.20.40.6-0.10.6
Reaction time mean minus median AUC0.91.11.41.2-0.91.1
Reaction time num false alarms2.33.24.9-2.10.7-2.2
Reaction time num false alarms AUC1.21.72.5-1.60.5-1.6
Reaction time trials correct on left0.81.21.81.3-0.71.1
Reaction time trials on left0.91.31.91.4-0.81.1
Reaction time mean0.10.20.3-0.30.6-0.4
Reaction time mean AUC0.20.20.3-0.30.5-0.5
Median of all reaction times0.20.20.3-0.40.6-0.5
Reaction time omissions0.10.10.2-0.4-0.40.0
Reaction time false alarm rate1.92.84.1-2.00.6-2.0
Reaction time premature initiation rate0.20.30.5-0.70.3-0.5
Reaction time premature initiations0.00.10.10.1-0.30.3
Std. dev. reaction times0.10.20.5-0.30.7-0.1
Reaction time trials completed0.91.31.91.4-0.81.1
Reaction time trials AUC0.81.11.71.3-0.71.1
Social response proportion0.50.50.7-0.50.7-0.9
Social responses1.92.42.7-1.51.5-1.6
Social time0.70.91.8-0.80.1-1.4
Conditioned locomotion0.10.10.10.3-0.30.3
Cocaine response after cond. corrected0.70.71.1-1.00.2-1.0
Cocaine response after cond. not corrected0.10.10.30.0-0.6-0.1
Cocaine response before conditioning2.02.53.71.9-1.01.6
Saline control response0.81.01.40.8-1.21.0
Condit. Reinf. active minus inactive responses2.63.25.51.2-2.31.7
Condit. Reinf. active-inactive response ratio0.60.61.50.2-1.20.5
Condit. Reinf. active responses2.83.95.61.4-2.42.1
Condit. Reinf. inactive responses1.11.42.31.1-0.81.5
Condit. Reinf. lever presses12.116.721.53.8-3.74.6
Condit. Reinf. lever reinforcers received3.65.06.81.7-2.62.3
Pavlov. Cond. lever latency14.019.223.6-3.94.3-4.9
Pavlov. Cond. magazine entry latency6.06.97.72.4-2.72.8
Pavlov. Cond. change in total contacts10.214.216.63.4-3.84.1
Pavlov. Cond. index score11.414.918.33.4-3.84.3
Pavlov. Cond. latency score11.614.717.33.4-3.94.2
Pavlov. Cond. lever contacts14.319.824.24.0-4.44.9
Pavlov. Cond. magazine entry number6.37.89.0-2.33.0-3.0
Pavlov. Cond. intertrial magazine entries1.41.82.5-1.21.6-1.2
Pavlov. Cond. lever-magazine prob. diff.10.713.816.93.3-3.74.1
Pavlov. Cond. response bias13.819.023.93.9-4.24.9
Conditioned reinforcement - actives2.92.83.61.7-1.51.9
Conditioned reinforcement - inactives0.00.00.0-0.10.2-0.0
Conditioned locomotion2.73.33.81.7-1.81.9
Intermittent access intake day 1-15 change3.43.43.61.8-1.81.9
Intermittent access intake escalation4.03.94.42.0-1.92.1
Intermittent access intake escalation 20.80.80.80.8-0.90.9
Intermitt. access day 1 inactive lever presses0.40.40.5-0.60.7-0.6
Intermitt. access day 15 inactive lever presses0.10.10.20.2-0.40.1
Intermitt. access escalation Index0.00.00.00.2-0.20.1
Intermittent access day 1 total infusions0.10.10.20.20.00.5
Intermittent access day 15 total infusions2.62.93.91.6-1.52.0
Intermittent access terminal intake (last 3 days)1.01.11.50.9-1.01.2
Intermittent access total infusions0.30.30.50.4-0.40.7
Intermittent access day 1 locomotion0.10.10.10.2-0.20.3
Intermittent access day 15 total locomotion1.41.52.11.2-1.01.4
Intermittent access total locomotion0.20.30.40.4-0.50.6
Intermittent access standard deviation0.00.00.0-0.1-0.20.1
Cocaine induced anxiety1.21.42.1-1.20.8-1.5
Post-drug Anxiety0.20.20.3-0.50.3-0.5
Baseline Anxiety1.92.02.91.4-1.01.7
Lifetime Intake0.50.60.90.6-0.71.0
Incentive Sensitization - Responses0.50.50.90.5-0.70.9
Incentive Sensitization - Breakpoint0.70.71.00.6-0.81.0
Progressive ratio test 1 active lever presses0.00.00.0-0.1-0.1-0.1
Progressive ratio test 1 breakpoint0.00.00.0-0.1-0.0-0.2
Progressive ratio test 1 inactive lever presses0.00.00.00.0-0.10.1
Progressive ratio test 2 active lever presses0.20.30.50.3-0.40.7
Progressive ratio test 2 breakpoint0.20.20.40.3-0.50.6
Progressive ratio test 2 inactive lever presses0.10.10.20.1-0.30.5
Total sessions with >9 infusions2.22.42.71.5-1.51.6
Short access day 1 total inactive lever presses0.00.00.0-0.10.00.1
Short access day 10 total inactive lever presses0.00.00.00.10.2-0.2
Short access day 1 total infusions1.51.62.11.2-1.01.5
Short access day 10 total infusions0.10.10.10.1-0.40.3
Short access total infusions0.20.30.30.4-0.60.6
Short access day 1 locomotion4.44.75.12.2-2.12.3
Short access day 10 total locomotion0.20.20.50.2-0.70.3
Short access total locomotion0.40.40.50.7-0.70.5
Compulsive drug intake0.10.10.20.2-0.40.1
One hour access (0.3 mA shock)0.50.61.00.5-0.71.0
One hour access (shock baseline)0.70.91.30.9-0.71.2
Number of responses in last shaping day0.70.70.9-0.90.6-0.9
Context. condit. distance diff. score1.31.52.01.1-1.21.4
Locomotion velocity, session 10.30.40.40.50.70.7
Locomotion distance, session 11.31.72.11.2-1.51.2
Locomotion velocity, session 20.20.20.40.30.70.4
Locomotion distance, session 20.20.30.40.7-0.20.6
Locomotion velocity, session 30.10.10.20.50.10.5
Locomotion distance, session 30.91.01.51.0-0.71.2
Stereotopy head waving bouts, day 30.80.92.0-0.41.4-0.8
Stereotopy head waving duration, day 30.30.40.70.80.30.6
Locomotion velocity, session 70.30.30.5-0.70.5-0.4
Locomotion distance, session 70.20.20.5-0.70.1-0.5
Stereotopy head waving bouts, day 71.51.72.11.5-0.91.5
Stereotopy head waving duration, day 71.31.62.51.4-0.71.6
Locomotion velocity, session 81.01.32.21.1-0.71.5
Locomotion distance, session 81.11.72.11.3-1.11.4
Degree of sensitization distance1.21.21.7-1.30.6-1.3
Degree of sensitization stereotypy4.65.05.92.2-2.12.4
Condit. Reinf. active minus inactive responses1.11.21.6-1.01.3-1.0
Condit. Reinf. active-inactive response ratio0.50.61.1-0.61.0-0.5
Condit. Reinf. active responses1.11.31.8-1.01.3-1.1
Condit. Reinf. inactive responses0.20.20.3-0.50.4-0.5
Incentive salience index mean1.11.31.9-1.11.4-0.9
Condit. Reinf. lever presses0.40.61.3-0.61.1-0.4
Time in familiar zone, hab. session 10.10.10.2-0.30.4-0.3
Time in novel zone, hab. session 10.20.20.3-0.60.2-0.5
Total zone transitions, hab. session 11.01.32.31.5-0.81.1
Total locomotion distance, hab. session 11.72.44.2-1.41.0-2.0
Locomotion velocity, hab. session 11.11.52.9-1.10.7-1.7
Time in familiar zone, hab. session 20.00.10.1-0.20.30.1
Time in novel zone, hab. session 20.20.20.50.2-0.70.2
Total zone transitions, hab. session 23.64.66.62.0-2.61.7
Total locomotion distance, hab. session 20.70.91.6-0.9-0.5-1.3
Locomotion velocity, hab. session 20.71.02.0-1.0-0.3-1.4
Novel to familiar place preference ratio0.80.81.50.8-1.20.7
Novelty place preference0.50.51.00.6-1.00.5
Time in novel zone, NPP test0.60.61.10.7-1.00.6
Total zone transitions, NPP test0.91.31.71.1-1.31.0
Total locomotion distance, NPP test1.21.62.9-1.4-0.1-1.7
Locomotion velocity, NPP test1.42.03.7-1.5-0.0-1.9
Pavlov. Cond. lever latency0.10.10.2-0.3-0.1-0.5
Pavlov. Cond. magazine entry latency0.60.81.00.7-1.01.0
Pavlov. Cond. change in total contacts0.40.40.90.3-1.00.5
Pavlov. Cond. index score0.10.10.40.2-0.20.6
Pavlov. Cond. latency score0.20.20.40.3-0.40.7
Pavlov. Cond. lever contacts0.10.10.2-0.30.5-0.0
Pavlov. Cond. magazine entry number0.70.81.2-0.80.8-1.1
Pavlov. Cond. intertrial magazine entries1.51.72.1-1.11.5-1.3
Pavlov. Cond. lever-magazine prob. diff.0.10.10.30.20.00.5
Pavlov. Cond. response bias0.10.10.2-0.20.40.0
Bone: apparent density0.20.41.1-0.21.1-0.1
Bone surface0.20.41.00.50.11.0
Bone volume0.20.30.7-0.20.80.2
Bone: connectivity density0.30.50.60.60.70.8
Bone: cortical apparent density1.21.62.2-1.01.5-1.2
Bone: cortical area0.10.10.2-0.4-0.5-0.1
Bone: cortical porosity2.12.22.51.6-1.51.4
Bone: cortical porosity1.51.62.01.4-1.11.2
Bone: cortical thickness0.20.30.5-0.7-0.2-0.7
Bone: cortical thickness1.01.23.40.2-1.90.3
Bone: cortical tissue density1.21.62.3-1.01.5-1.2
Bone: elastic displacement0.40.50.6-0.70.6-0.7
Bone: elastic work0.20.20.3-0.50.5-0.3
Bone: endosteal estimation0.00.10.3-0.50.10.1
Bone: endosteal perimeter0.10.30.70.3-0.10.8
Bone: final force0.20.30.60.3-0.80.3
Bone: final moment0.10.20.40.3-0.60.4
Bone: marrow area0.10.10.3-0.50.20.0
Bone: maximum diameter0.50.91.40.5-1.21.0
Bone: maximum force0.30.50.80.5-0.90.6
Bone: maximum moment0.20.40.50.5-0.70.7
Bone: minimum diameter0.81.42.0-1.41.2-0.9
Bone: periosteal estimation0.10.10.2-0.5-0.30.2
Bone: periosteal perimeter0.10.10.30.10.10.5
Bone: post-yield work0.30.40.60.80.10.8
Bone: stiffness0.20.30.80.2-0.9-0.0
Bone: tissue strength1.11.11.91.0-1.40.6
Bone: trabecular number0.61.01.9-0.81.4-0.7
Bone: trabecular spacing1.51.92.31.5-1.11.5
Bone: trabecular thickness1.21.51.9-1.21.4-1.0
Bone: trabecular tissue density0.71.02.1-1.00.0-1.4
Breakpoint value in progressive ratio session0.00.00.0-0.0-0.1-0.2
Distance traveled before self-admin0.20.20.2-0.50.4-0.4
Distance traveled after self-admin0.00.00.00.1-0.0-0.1
Delta time in closed arm before/after self-admin2.62.53.1-1.61.8-1.4
Delta time in open arm before/after self-admin0.90.91.21.0-0.71.1
Diff in mean of infusions in LGA sessions2.52.84.5-1.71.0-2.1
Extinction: sum of active levers before priming0.30.40.4-0.60.7-0.5
Active lever presses in extinction session 66.36.07.32.7-2.22.5
Delta distance traveled before/after self-admin0.50.50.60.8-0.70.6
Delta ambulatory time before/after self-admin0.80.91.11.0-0.90.8
Time in closed arm before self-admin2.52.83.31.8-1.41.8
Time in closed arm after self-admin0.10.10.20.40.10.4
Time in open arm before self-admin2.42.64.0-1.61.1-2.0
Time in open arm after self-admin0.30.30.4-0.60.6-0.6
Sum of active levers in priming session hrs 5-60.00.00.00.0-0.2-0.1
Time to tail flick, vehicle, before self-admin0.90.91.2-1.10.6-1.1
Time to tail flick, vehicle, after self-admin2.02.12.41.4-1.41.6
Time to tail flick, test, before self-admin0.10.10.1-0.3-0.1-0.4
Time to tail flick, test, after self-admin0.20.20.3-0.40.6-0.1
Delta time to tail flick, vehicle, before/after SA5.04.95.82.3-1.92.4
Delta time to tail flick, test, before/after SA0.10.10.10.20.30.2
Ambulatory time before self-admin0.10.10.1-0.30.3-0.2
Ambulatory time after self-admin0.10.10.20.4-0.10.2
Total heroin consumption0.30.40.80.5-0.90.2
Area under the delay curve0.20.30.50.2-0.70.4
Delay disc. indifference point, 0s delay0.30.40.70.3-0.90.6
Delay disc. indifference point, 16s delay0.10.10.30.4-0.10.6
Delay disc. indifference point, 2s delay1.61.82.51.1-1.61.2
Delay disc. indifference point, 24s delay0.50.50.7-0.90.4-0.7
Delay disc. indifference point, 4s delay0.20.20.4-0.1-0.60.4
Delay disc. indifference point, 8s delay0.50.50.90.4-0.90.7
Delay discount exponential model param0.20.20.4-0.20.7-0.5
Delay discount hyperbolic model param0.30.30.6-0.30.7-0.6
Fecal boli incidents, locomotor time 11.21.32.11.1-0.81.4
Change in fecal boli incidents, locomotor task0.50.40.6-0.50.7-0.8
Time >=10cm from walls, locomotor time 12.42.43.71.8-0.61.9
Bouts of movement, locomotor time 10.20.20.30.50.20.5
Total resting periods, locomotor time 10.20.30.40.60.00.6
Rest time, locomotor task time 10.20.20.40.6-0.10.5
Distance moved, locomotor task time 10.50.51.2-1.1-0.0-0.6
Vertical activity count, locomotor time 10.50.51.1-0.7-1.0-0.3
Time >=10cm from walls, locomotor time 20.50.50.70.8-0.40.8
Bouts of movement, locomotor time 20.40.40.60.70.40.7
Total resting periods, locomotor time 20.30.30.40.70.40.6
Rest time, locomotor task time 20.80.91.5-0.71.2-0.9
Distance moved, locomotor task time 21.01.23.00.2-1.70.8
Vertical activity count, locomotor time 20.50.51.3-0.5-1.1-0.2
Weight adjusted by age0.50.50.9-1.00.4-0.7
Seeking ratio, delayed vs. immediate footshock1.41.62.0-1.41.2-1.2
Locomotion in novel chamber1.72.12.51.5-1.31.6
Locomotion in novel chamber post-restriction5.66.77.92.7-2.22.8
Progressive ratio0.50.61.20.6-1.10.5
Food seeking constrained by brief footshock0.60.71.31.0-0.01.1
Seeking ratio, punishment vs. effort0.20.20.60.00.70.3
Run reversals in cocaine runway, females4.74.75.7-2.42.0-2.1
Run reversals in cocaine runway, males0.20.20.30.5-0.10.5
Latency to leave start box in cocaine runway0.70.81.2-0.80.7-1.1
Latency to leave start box in cocaine runway, F1.11.21.8-1.20.6-1.3
Latency to leave start box in cocaine runway, M0.10.10.30.5-0.20.2
Cd content in liver1.61.82.2-1.51.0-1.4
Co content in liver0.50.51.0-0.71.0-0.3
Cu content in liver0.10.10.1-0.20.2-0.4
Fe content in liver0.10.20.3-0.4-0.6-0.1
K content in liver0.60.61.1-0.51.0-0.7
Mg content in liver0.10.10.10.30.00.3
Mn content in liver0.10.10.10.0-0.3-0.4
Na content in liver1.71.82.71.6-1.01.3
Rb content in liver0.00.00.00.10.20.1
Se content in liver1.31.52.3-1.11.1-1.5
Sr content in liver0.00.00.10.1-0.20.2
Zn content in liver2.42.63.21.5-1.81.6