Pikfyve

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000015158	0.09	0.05	7.8e-07	0.01	0.04	0.03	0.03	3.5e-02	2.6e-05	1.3e-04	5.8e-04
2	Brain	gene expression	ENSRNOG00000015158	0.05	0.03	1.0e-05	0.06	0.06	0.06	0.06	2.6e-06	4.9e-06	2.3e-06	6.4e-06
3	Eye	gene expression	ENSRNOG00000015158	0.72	0.15	1.9e-06	0.16	0.36	0.37	0.37	1.7e-03	1.6e-06	1.0e-06	1.1e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
BMI with tail	8.0	25.9	29.9	5.0	-5.5	-4.7
BMI without tail	4.0	8.4	9.7	2.6	-3.1	-3.0
Body weight	0.4	1.8	2.1	1.2	-1.3	-1.4
Epididymis fat weight	0.0	0.0	0.1	0.1	0.3	-0.0
Glucose	0.7	1.1	1.4	1.2	-1.2	-0.8
Heart weight	0.8	1.1	2.1	-0.8	0.7	1.4
Left kidney weight	0.0	0.1	0.2	0.3	-0.5	0.2
Right kidney weight	0.0	0.0	0.0	0.0	-0.1	0.1
Tail length	3.7	11.3	15.5	-3.7	3.9	2.2
Length with tail	4.8	17.5	22.0	-4.5	4.7	3.2
Length without tail	1.2	2.7	3.3	-1.5	1.8	1.6
Liver weight, left	1.6	2.6	3.6	-1.9	1.6	1.3
Liver weight, right	0.4	0.6	0.8	-0.9	0.8	0.6
Parametrial fat weight	0.2	0.4	0.7	-0.4	0.8	-0.7
Retroperitoneal fat weight	0.8	2.6	3.3	1.8	-1.4	-1.6
Intraocular pressure	3.1	4.3	5.7	2.0	-1.8	-2.4
Extensor digitorum longus weight	2.5	10.0	12.0	3.0	-3.0	-3.5
Soleus weight	0.2	0.6	1.4	0.3	-0.6	-1.2
Tibialis anterior weight	0.6	2.0	2.4	1.3	-1.5	-1.4
Tibia length	1.1	3.1	4.9	-1.7	2.2	1.2
Number of licking bursts	0.1	0.1	0.2	0.5	-0.2	0.1
Food consumed during 24 hour testing period	0.5	0.6	0.8	-0.9	0.7	0.6
Times rat made contact with spout	0.7	0.8	1.0	-0.9	1.0	0.8
Mean time between licks in bursts	0.4	0.5	0.6	0.6	-0.8	-0.8
Mean num. licks in bursts	0.2	0.2	0.3	-0.6	0.6	0.0
Std. dev. time between licks in bursts	3.2	3.8	4.6	1.7	-1.9	-2.1
Water consumed over 24 hours	0.2	0.2	0.4	0.5	-0.6	-0.1
Indifference point 0 sec	1.0	1.6	2.2	1.2	-1.1	-1.5
Indifference point AUC	0.1	0.1	0.2	-0.2	0.4	-0.1
Indifference point function ln k	0.8	1.1	2.1	1.0	-1.5	-0.5
Indifference point function log k	0.8	1.1	2.1	1.0	-1.5	-0.5
Delay discounting total patch changes 0 sec	0.8	1.3	1.6	1.1	-1.0	-1.3
Delay discounting total patch changes 12 sec	0.0	0.1	0.2	0.4	-0.0	0.1
Delay discounting total patch changes 18 sec	1.0	1.3	1.9	1.1	-0.8	-1.4
Delay discounting total patch changes 24 sec	0.1	0.2	0.3	0.5	-0.1	-0.6
Delay discounting total patch changes 6 sec	1.2	1.8	2.2	1.2	-1.3	-1.5
Delay discounting time to switch 0 sec	0.1	0.1	0.1	-0.3	0.2	0.3
Delay discounting water rate 0 sec	0.4	0.6	1.0	0.8	-0.3	-1.0
Delay discounting water rate 12 sec	0.1	0.2	0.4	0.3	-0.6	-0.4
Delay discounting water rate 18 sec	0.8	1.1	1.6	-1.0	0.9	1.3
Delay discounting water rate 24 sec	0.1	0.1	0.2	-0.1	0.2	-0.5
Delay discounting water rate 6 sec	1.3	1.8	1.9	1.3	-1.4	-1.4
Locomotor activity	0.0	0.0	0.0	0.2	0.2	-0.1
Locomotor testing distance	0.0	0.0	0.0	0.2	0.0	-0.2
Locomotor testing rearing	0.0	0.1	0.1	-0.1	0.2	0.3
Light reinforcement 1	1.2	2.3	3.4	1.5	-1.8	-1.0
Light reinforcement 2	1.1	1.4	1.6	-1.3	1.0	1.2
Reaction time number correct	0.1	0.2	0.4	0.1	-0.6	0.2
Reaction time mean minus median	0.1	0.1	0.2	0.1	-0.3	-0.4
Reaction time mean minus median AUC	0.0	0.1	0.2	-0.4	0.1	-0.0
Reaction time num false alarms	3.4	4.7	5.5	2.3	-2.3	-1.9
Reaction time num false alarms AUC	3.2	4.5	4.5	2.1	-2.1	-2.1
Reaction time trials correct on left	0.1	0.2	0.4	0.1	-0.6	0.2
Reaction time trials on left	0.1	0.2	0.4	0.1	-0.6	0.2
Reaction time mean	2.6	3.6	4.4	-1.9	2.1	1.6
Reaction time mean AUC	1.9	2.6	3.2	-1.6	1.8	1.3
Median of all reaction times	4.0	5.4	6.8	-2.3	2.6	2.0
Reaction time omissions	0.0	0.0	0.1	-0.0	-0.1	-0.3
Reaction time false alarm rate	1.9	2.7	3.5	1.7	-1.4	-1.9
Reaction time premature initiation rate	0.3	0.4	0.6	-0.7	0.5	0.7
Reaction time premature initiations	0.1	0.2	0.4	-0.5	0.0	0.6
Std. dev. reaction times	0.3	0.4	0.5	-0.7	0.7	0.5
Reaction time trials completed	0.1	0.2	0.4	0.1	-0.6	0.2
Reaction time trials AUC	0.1	0.1	0.3	-0.0	-0.5	0.3
Social response proportion	0.2	0.2	0.4	-0.6	0.5	0.2
Social responses	0.4	0.5	0.5	-0.7	0.7	0.6
Social time	0.6	0.8	1.2	-0.9	0.6	1.1
Conditioned locomotion	0.7	0.9	1.3	-1.2	1.1	0.1
Cocaine response after cond. corrected	0.9	1.1	2.0	-1.4	1.1	0.1
Cocaine response after cond. not corrected	1.6	1.8	3.0	-1.7	1.4	0.7
Cocaine response before conditioning	0.5	0.6	1.7	-0.1	0.3	1.3
Saline control response	0.9	1.2	1.5	0.8	-1.2	-1.2
Condit. Reinf. active minus inactive responses	7.3	9.1	11.0	-3.3	3.1	2.5
Condit. Reinf. active-inactive response ratio	7.0	7.3	8.5	-2.9	2.8	2.4
Condit. Reinf. active responses	4.8	6.7	7.9	-2.8	2.6	2.2
Condit. Reinf. inactive responses	0.2	0.3	0.3	-0.6	0.6	0.5
Condit. Reinf. lever presses	1.0	1.3	1.6	-1.2	1.1	1.1
Condit. Reinf. lever reinforcers received	5.3	7.5	9.0	-3.0	2.8	2.4
Pavlov. Cond. lever latency	1.6	2.2	2.5	1.5	-1.4	-1.6
Pavlov. Cond. magazine entry latency	0.3	0.4	0.7	-0.4	0.5	0.8
Pavlov. Cond. change in total contacts	1.4	2.0	2.5	-1.6	1.4	1.2
Pavlov. Cond. index score	2.0	2.6	2.8	-1.6	1.6	1.7
Pavlov. Cond. latency score	1.8	2.3	2.6	-1.5	1.5	1.6
Pavlov. Cond. lever contacts	2.8	3.9	4.1	-2.0	1.9	2.0
Pavlov. Cond. magazine entry number	0.9	1.1	2.0	0.8	-0.8	-1.4
Pavlov. Cond. intertrial magazine entries	2.0	2.6	3.0	1.3	-1.7	-1.7
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.3	2.4	-1.5	1.5	1.6
Pavlov. Cond. response bias	2.5	3.5	3.7	-1.9	1.8	1.9
Conditioned reinforcement - actives	0.6	0.6	1.2	0.6	-0.5	-1.1
Conditioned reinforcement - inactives	1.1	1.3	2.4	-1.2	1.5	0.1
Conditioned locomotion	6.8	8.2	9.0	3.0	-2.8	-2.8
Intermittent access intake day 1-15 change	0.1	0.1	0.2	-0.2	-0.2	0.4
Intermittent access intake escalation	0.2	0.2	0.4	-0.4	-0.1	0.6
Intermittent access intake escalation 2	0.5	0.5	0.9	-0.7	0.1	1.0
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.3	0.3	0.4	-0.5
Intermitt. access day 15 inactive lever presses	1.0	1.2	1.4	-1.1	1.0	1.2
Intermitt. access escalation Index	1.8	1.6	2.7	1.4	-1.6	0.4
Intermittent access day 1 total infusions	0.2	0.2	0.6	0.3	-0.2	-0.8
Intermittent access day 15 total infusions	0.2	0.2	0.4	0.4	-0.6	-0.3
Intermittent access terminal intake (last 3 days)	0.3	0.4	0.7	0.5	-0.8	-0.3
Intermittent access total infusions	0.2	0.2	0.5	0.2	-0.2	-0.7
Intermittent access day 1 locomotion	0.4	0.4	0.7	0.8	-0.2	-0.8
Intermittent access day 15 total locomotion	0.1	0.1	0.2	0.4	-0.2	-0.0
Intermittent access total locomotion	1.0	1.2	1.4	1.2	-0.8	-1.2
Intermittent access standard deviation	0.9	0.9	1.1	-1.0	0.9	0.9
Cocaine induced anxiety	0.3	0.3	0.7	0.4	-0.8	-0.2
Post-drug Anxiety	0.4	0.5	0.7	0.5	-0.8	-0.6
Baseline Anxiety	0.5	0.5	0.9	-0.8	0.9	0.0
Lifetime Intake	0.6	0.7	1.4	0.6	-0.5	-1.2
Incentive Sensitization - Responses	0.0	0.0	0.1	-0.3	0.2	0.1
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	-0.3	0.1	0.0
Progressive ratio test 1 active lever presses	0.2	0.2	0.4	0.7	-0.5	-0.2
Progressive ratio test 1 breakpoint	0.1	0.2	0.3	0.5	-0.4	0.2
Progressive ratio test 1 inactive lever presses	1.8	1.9	2.4	1.6	-1.2	-1.4
Progressive ratio test 2 active lever presses	0.1	0.1	0.1	0.3	-0.3	-0.4
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	-0.0	-0.1	-0.1
Progressive ratio test 2 inactive lever presses	0.3	0.3	0.5	0.7	-0.4	-0.6
Total sessions with >9 infusions	0.2	0.2	0.5	-0.0	0.0	-0.7
Short access day 1 total inactive lever presses	0.3	0.4	0.5	0.7	-0.4	-0.6
Short access day 10 total inactive lever presses	1.0	1.1	1.6	-0.8	1.3	1.0
Short access day 1 total infusions	0.2	0.2	0.3	0.4	-0.6	-0.4
Short access day 10 total infusions	0.1	0.1	0.3	-0.5	0.3	-0.1
Short access total infusions	1.0	1.1	2.2	0.7	-0.7	-1.5
Short access day 1 locomotion	0.5	0.6	0.9	-0.7	0.9	0.6
Short access day 10 total locomotion	0.2	0.2	0.5	-0.4	0.7	0.4
Short access total locomotion	0.2	0.2	0.4	0.5	-0.3	-0.6
Compulsive drug intake	0.1	0.1	0.2	0.1	0.5	-0.4
One hour access (0.3 mA shock)	0.1	0.1	0.1	0.0	0.3	-0.2
One hour access (shock baseline)	0.0	0.0	0.0	-0.2	0.0	0.1
Number of responses in last shaping day	0.7	0.8	1.0	-0.8	1.0	0.8
Context. condit. distance diff. score	0.4	0.4	0.6	0.7	-0.7	0.6
Locomotion velocity, session 1	1.0	1.1	1.8	-1.0	1.3	-0.6
Locomotion distance, session 1	0.6	0.8	2.4	-0.1	0.4	-1.5
Locomotion velocity, session 2	0.4	0.5	1.5	-0.0	-0.0	-1.2
Locomotion distance, session 2	1.4	2.0	5.4	0.7	-0.3	-2.3
Locomotion velocity, session 3	0.3	0.4	0.7	0.4	-0.8	0.5
Locomotion distance, session 3	1.3	1.4	2.0	-1.0	1.4	1.1
Stereotopy head waving bouts, day 3	1.7	2.0	2.9	1.4	-1.7	-1.1
Stereotopy head waving duration, day 3	1.8	2.2	4.1	1.3	-2.0	-1.0
Locomotion velocity, session 7	0.1	0.1	0.1	0.3	-0.2	-0.3
Locomotion distance, session 7	0.5	0.6	1.5	0.1	0.5	-1.2
Stereotopy head waving bouts, day 7	0.1	0.1	0.3	0.3	-0.5	0.3
Stereotopy head waving duration, day 7	0.9	1.1	2.2	1.0	-1.5	0.1
Locomotion velocity, session 8	0.0	0.0	0.1	0.3	-0.3	0.1
Locomotion distance, session 8	0.2	0.2	0.4	0.5	-0.2	-0.6
Degree of sensitization distance	1.8	1.8	3.8	0.9	-0.9	-1.9
Degree of sensitization stereotypy	0.2	0.3	0.5	0.5	-0.7	-0.0
Condit. Reinf. active minus inactive responses	1.4	1.6	2.5	-1.0	1.1	1.6
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.8	-0.3	0.3	0.9
Condit. Reinf. active responses	1.8	2.1	3.1	-1.2	1.3	1.8
Condit. Reinf. inactive responses	0.5	0.6	0.9	-0.8	1.0	0.5
Incentive salience index mean	1.7	2.0	3.4	-1.1	1.2	1.8
Condit. Reinf. lever presses	0.9	1.2	2.2	-0.8	0.9	1.5
Time in familiar zone, hab. session 1	1.4	1.3	2.0	1.1	-1.4	-0.9
Time in novel zone, hab. session 1	6.3	6.2	6.9	-2.6	2.5	2.3
Total zone transitions, hab. session 1	0.5	0.6	0.9	-0.9	1.0	-0.4
Total locomotion distance, hab. session 1	1.5	2.2	2.9	-1.7	1.7	0.9
Locomotion velocity, hab. session 1	1.1	1.6	2.3	-1.4	1.5	0.7
Time in familiar zone, hab. session 2	0.4	0.4	0.8	0.9	-0.7	-0.3
Time in novel zone, hab. session 2	0.3	0.3	0.7	-0.8	0.4	0.2
Total zone transitions, hab. session 2	0.3	0.3	0.7	-0.3	0.4	-0.8
Total locomotion distance, hab. session 2	0.1	0.2	0.3	-0.2	0.5	-0.5
Locomotion velocity, hab. session 2	0.1	0.2	0.3	-0.2	0.5	-0.5
Novel to familiar place preference ratio	1.0	1.1	1.8	-1.3	1.2	0.2
Novelty place preference	1.2	1.3	2.2	-1.5	1.2	0.4
Time in novel zone, NPP test	1.6	1.7	2.7	-1.7	1.3	0.7
Total zone transitions, NPP test	0.2	0.3	0.5	-0.2	0.6	-0.7
Total locomotion distance, NPP test	0.4	0.5	0.9	-0.5	1.0	-0.6
Locomotion velocity, NPP test	0.3	0.5	1.1	-0.1	0.6	-1.0
Pavlov. Cond. lever latency	0.0	0.0	0.0	0.1	-0.1	0.1
Pavlov. Cond. magazine entry latency	0.6	0.8	1.5	-0.5	0.8	1.2
Pavlov. Cond. change in total contacts	0.1	0.2	0.2	0.4	-0.4	-0.4
Pavlov. Cond. index score	0.3	0.4	0.6	-0.6	0.6	0.8
Pavlov. Cond. latency score	0.3	0.3	0.5	-0.5	0.5	0.7
Pavlov. Cond. lever contacts	0.0	0.0	0.0	-0.2	0.1	0.1
Pavlov. Cond. magazine entry number	0.2	0.3	0.5	0.5	-0.7	-0.4
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	-0.3	0.0	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.4	0.6	-0.5	0.6	0.8
Pavlov. Cond. response bias	0.3	0.3	0.5	-0.5	0.7	0.5
Bone: apparent density	0.5	0.9	2.2	-0.6	0.4	1.5
Bone surface	0.4	0.7	1.6	-0.6	0.5	1.2
Bone volume	1.4	2.4	4.5	-1.2	1.1	2.1
Bone: connectivity density	0.3	0.5	1.0	0.8	-1.0	-0.0
Bone: cortical apparent density	3.9	5.1	5.5	2.3	-2.1	-2.3
Bone: cortical area	0.4	0.6	1.1	-0.5	1.1	0.7
Bone: cortical porosity	10.3	11.1	11.7	-3.3	3.3	3.4
Bone: cortical porosity	11.3	12.2	12.3	-3.5	3.5	3.5
Bone: cortical thickness	0.0	0.1	0.2	0.2	0.4	-0.1
Bone: cortical thickness	1.7	2.0	2.3	-1.3	1.4	1.5
Bone: cortical tissue density	4.3	5.6	6.0	2.4	-2.2	-2.4
Bone: elastic displacement	0.2	0.3	0.5	0.2	-0.5	0.7
Bone: elastic work	1.0	1.3	2.8	-0.6	0.7	1.7
Bone: endosteal estimation	1.6	3.4	3.9	-1.7	1.8	2.0
Bone: endosteal perimeter	0.9	1.9	2.9	-1.2	1.2	1.7
Bone: final force	1.5	2.5	3.5	-1.2	1.6	1.9
Bone: final moment	1.1	1.9	2.8	-1.0	1.3	1.7
Bone: marrow area	1.5	3.1	3.3	-1.7	1.8	1.8
Bone: maximum diameter	1.0	1.7	2.3	-1.2	1.5	1.2
Bone: maximum force	0.7	1.2	1.9	-0.7	1.1	1.4
Bone: maximum moment	0.4	0.7	1.3	-0.5	0.8	1.1
Bone: minimum diameter	1.6	2.9	3.6	-1.4	1.8	1.9
Bone: periosteal estimation	1.6	3.2	4.1	-1.6	2.0	1.8
Bone: periosteal perimeter	1.6	2.6	2.9	-1.5	1.7	1.7
Bone: post-yield work	0.0	0.1	0.1	0.4	0.1	-0.0
Bone: stiffness	0.6	0.9	1.3	-0.7	0.9	1.1
Bone: tissue strength	0.2	0.2	0.3	0.6	-0.3	-0.2
Bone: trabecular number	0.2	0.3	0.5	0.4	-0.6	0.7
Bone: trabecular spacing	0.3	0.4	0.6	-0.3	0.8	-0.6
Bone: trabecular thickness	0.6	0.8	1.5	-0.6	0.6	1.2
Bone: trabecular tissue density	0.4	0.6	1.3	-0.3	1.2	-0.7
Breakpoint value in progressive ratio session	0.8	0.9	1.8	-0.6	0.8	1.3
Distance traveled before self-admin	3.2	3.5	3.7	-1.9	1.9	1.8
Distance traveled after self-admin	0.2	0.2	0.7	0.8	-0.3	0.0
Delta time in closed arm before/after self-admin	0.7	0.7	1.1	0.6	-1.0	-0.8
Delta time in open arm before/after self-admin	3.2	3.0	3.3	-1.7	1.8	1.6
Diff in mean of infusions in LGA sessions	0.3	0.3	0.4	0.5	-0.7	0.5
Extinction: sum of active levers before priming	0.3	0.3	0.6	0.5	-0.4	0.8
Active lever presses in extinction session 6	0.1	0.1	0.3	-0.3	0.5	0.2
Delta distance traveled before/after self-admin	2.5	2.6	4.1	2.0	-1.8	-0.7
Delta ambulatory time before/after self-admin	2.2	2.4	3.7	1.9	-1.6	-0.8
Time in closed arm before self-admin	1.9	2.2	3.5	-1.1	1.4	1.9
Time in closed arm after self-admin	0.1	0.1	0.2	-0.2	0.4	0.4
Time in open arm before self-admin	2.9	3.0	3.9	1.5	-1.7	-2.0
Time in open arm after self-admin	0.5	0.6	0.9	-0.8	0.9	0.4
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.6	-0.3	0.6	0.8
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.3	0.6	-0.5	-0.2
Time to tail flick, vehicle, after self-admin	0.6	0.7	1.2	-0.9	1.1	0.2
Time to tail flick, test, before self-admin	0.6	0.6	0.9	-0.9	1.0	-0.5
Time to tail flick, test, after self-admin	3.2	3.3	3.6	1.9	-1.7	-1.8
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	-0.2	0.2	-0.1
Delta time to tail flick, test, before/after SA	2.3	2.0	2.9	1.7	-1.7	-0.6
Ambulatory time before self-admin	1.2	1.3	1.5	-1.1	1.1	1.2
Ambulatory time after self-admin	1.7	1.9	3.6	1.9	-1.4	-0.4
Total heroin consumption	0.6	0.7	0.9	-0.7	1.0	0.8
Area under the delay curve	0.4	0.4	0.9	0.3	-0.3	-1.0
Delay disc. indifference point, 0s delay	1.5	1.7	1.9	1.2	-1.4	-1.3
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	-0.3	0.1	0.3
Delay disc. indifference point, 2s delay	1.4	1.6	1.7	1.2	-1.3	-1.2
Delay disc. indifference point, 24s delay	0.2	0.2	0.2	0.5	-0.4	-0.4
Delay disc. indifference point, 4s delay	2.2	2.3	3.9	1.2	-1.3	-2.0
Delay disc. indifference point, 8s delay	0.2	0.2	0.6	-0.0	0.1	-0.8
Delay discount exponential model param	0.3	0.3	0.8	-0.2	0.3	0.9
Delay discount hyperbolic model param	0.6	0.6	1.4	-0.4	0.5	1.2
Fecal boli incidents, locomotor time 1	1.7	1.8	2.1	-1.3	1.3	1.4
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	-0.7	0.4	-0.0
Time >=10cm from walls, locomotor time 1	1.6	1.6	2.7	-1.4	1.6	0.3
Bouts of movement, locomotor time 1	1.1	1.2	2.1	-1.3	1.4	-0.0
Total resting periods, locomotor time 1	0.8	0.9	1.5	-1.0	1.2	-0.6
Rest time, locomotor task time 1	1.3	1.4	2.1	-1.5	1.4	0.4
Distance moved, locomotor task time 1	1.3	1.4	2.0	1.4	-1.0	-1.1
Vertical activity count, locomotor time 1	1.0	1.0	1.5	1.2	-1.2	-0.2
Time >=10cm from walls, locomotor time 2	0.5	0.5	1.0	-0.8	1.0	-0.2
Bouts of movement, locomotor time 2	0.7	0.7	1.0	1.0	-0.7	-0.8
Total resting periods, locomotor time 2	0.2	0.2	0.4	0.6	-0.2	-0.5
Rest time, locomotor task time 2	1.3	1.6	2.3	-1.5	1.5	0.3
Distance moved, locomotor task time 2	1.7	2.0	2.5	1.5	-1.1	-1.6
Vertical activity count, locomotor time 2	3.6	3.9	4.9	2.2	-2.2	-1.5
Weight adjusted by age	0.1	0.1	0.3	0.1	0.2	0.6
Seeking ratio, delayed vs. immediate footshock	0.8	0.9	1.2	-1.1	0.7	1.0
Locomotion in novel chamber	1.2	1.5	2.8	1.3	-1.7	0.1
Locomotion in novel chamber post-restriction	0.1	0.2	0.4	0.6	-0.3	-0.2
Progressive ratio	0.1	0.1	0.3	-0.2	-0.0	-0.6
Food seeking constrained by brief footshock	1.6	2.0	3.0	1.6	-1.7	-0.4
Seeking ratio, punishment vs. effort	0.8	1.0	1.6	1.3	-1.1	0.3
Run reversals in cocaine runway, females	1.5	1.5	3.3	0.9	-0.7	-1.8
Run reversals in cocaine runway, males	0.3	0.3	0.4	-0.5	0.7	0.5
Latency to leave start box in cocaine runway	2.9	3.2	3.8	1.8	-1.6	-2.0
Latency to leave start box in cocaine runway, F	2.2	2.4	2.7	1.6	-1.3	-1.7
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	0.1	-0.2	0.0
Cd content in liver	0.1	0.1	0.2	0.2	-0.4	0.5
Co content in liver	0.0	0.0	0.1	0.3	-0.2	-0.1
Cu content in liver	0.1	0.1	0.3	0.3	0.1	0.5
Fe content in liver	0.7	0.8	1.9	-0.4	0.5	1.4
K content in liver	0.5	0.5	0.8	0.5	-0.7	-0.9
Mg content in liver	0.5	0.5	0.9	0.4	-1.0	-0.6
Mn content in liver	1.3	1.5	2.7	0.9	-1.6	-1.0
Na content in liver	0.5	0.6	1.2	-0.7	0.2	1.1
Rb content in liver	0.0	0.0	0.0	0.1	-0.1	-0.2
Se content in liver	0.2	0.2	0.3	0.5	-0.6	-0.3
Sr content in liver	0.1	0.1	0.2	-0.1	0.2	-0.4
Zn content in liver	0.4	0.5	0.7	0.8	-0.5	-0.7