Hub : Genes

Gucy2e

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose alternative polyA ENSRNOT00000020513 0.08 0.05 6.6e-06 0.05 0.04 0.04 0.05 4.1e-06 2.2e-05 2.5e-05 3.7e-06
2 Adipose alternative TSS ENSRNOT00000094359 0.04 0.03 1.3e-03 0.01 0.01 0 0 4.5e-02 6.5e-02 8.5e-02 1.5e-01
3 Adipose gene expression ENSRNOG00000015058 0.71 0.09 0.0e+00 0.5 0.48 0.48 0.49 5.3e-63 1.8e-60 7.3e-61 1.6e-61

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail0.00.00.10.3-0.10.1
BMI without tail0.40.91.5-0.61.2-1.0
Body weight0.21.01.3-0.90.9-1.1
Epididymis fat weight0.00.00.10.2-0.30.1
Glucose0.10.20.3-0.6-0.3-0.5
Heart weight0.91.21.9-1.01.4-0.9
Left kidney weight1.54.24.5-2.11.9-2.1
Right kidney weight0.92.63.1-1.71.4-1.7
Tail length2.88.59.2-2.82.9-3.0
Length with tail0.93.34.0-1.81.7-2.0
Length without tail0.30.61.00.6-1.00.6
Liver weight, left0.00.10.10.2-0.40.1
Liver weight, right0.40.71.00.9-1.00.6
Parametrial fat weight0.10.20.50.7-0.20.4
Retroperitoneal fat weight0.72.22.41.6-1.41.5
Intraocular pressure0.30.40.7-0.80.6-0.4
Extensor digitorum longus weight0.00.10.4-0.10.60.2
Soleus weight0.10.20.5-0.40.7-0.2
Tibialis anterior weight0.10.51.1-0.51.0-0.5
Tibia length0.82.33.0-1.31.7-1.4
Number of licking bursts4.35.15.12.3-2.22.3
Food consumed during 24 hour testing period2.53.03.7-1.91.3-1.9
Times rat made contact with spout0.00.00.10.3-0.10.1
Mean time between licks in bursts7.09.711.1-3.32.7-3.3
Mean num. licks in bursts3.94.74.9-2.12.2-2.1
Std. dev. time between licks in bursts1.72.02.5-1.41.3-1.6
Water consumed over 24 hours1.31.51.61.3-1.21.2
Indifference point 0 sec5.99.511.6-2.83.4-3.0
Indifference point AUC0.10.20.3-0.40.5-0.3
Indifference point function ln k0.60.91.0-1.00.8-1.0
Indifference point function log k0.60.91.0-1.00.8-1.0
Delay discounting total patch changes 0 sec4.87.89.4-2.53.1-2.7
Delay discounting total patch changes 12 sec2.02.74.2-1.42.0-1.4
Delay discounting total patch changes 18 sec2.83.74.0-1.92.0-1.9
Delay discounting total patch changes 24 sec0.91.11.5-1.10.8-1.2
Delay discounting total patch changes 6 sec1.01.53.1-0.81.8-0.9
Delay discounting time to switch 0 sec5.28.08.42.8-2.92.8
Delay discounting water rate 0 sec3.96.16.2-2.52.5-2.5
Delay discounting water rate 12 sec2.33.43.9-2.01.6-2.0
Delay discounting water rate 18 sec1.11.51.7-1.31.2-1.2
Delay discounting water rate 24 sec0.50.70.9-1.00.6-0.8
Delay discounting water rate 6 sec0.40.60.8-0.80.9-0.7
Locomotor activity1.32.12.7-1.31.3-1.6
Locomotor testing distance3.35.46.4-2.32.2-2.5
Locomotor testing rearing1.52.33.1-1.41.4-1.7
Light reinforcement 11.73.23.51.9-1.81.7
Light reinforcement 20.10.10.20.4-0.50.2
Reaction time number correct0.10.20.20.5-0.40.3
Reaction time mean minus median1.72.22.6-1.41.5-1.6
Reaction time mean minus median AUC1.72.22.7-1.41.4-1.6
Reaction time num false alarms1.92.63.01.7-1.51.7
Reaction time num false alarms AUC1.31.82.01.2-1.41.4
Reaction time trials correct on left0.10.20.20.5-0.40.3
Reaction time trials on left0.10.10.20.5-0.40.3
Reaction time mean0.00.00.10.1-0.3-0.0
Reaction time mean AUC0.20.30.60.3-0.80.3
Median of all reaction times0.30.40.70.6-0.90.5
Reaction time omissions0.00.00.0-0.2-0.1-0.1
Reaction time false alarm rate1.01.51.81.1-1.21.3
Reaction time premature initiation rate2.73.66.0-1.52.4-1.6
Reaction time premature initiations1.82.64.4-1.22.1-1.3
Std. dev. reaction times1.01.31.5-1.11.1-1.2
Reaction time trials completed0.10.10.20.5-0.40.3
Reaction time trials AUC0.00.10.10.3-0.30.1
Social response proportion0.40.40.50.7-0.70.5
Social responses0.30.40.50.7-0.50.6
Social time3.95.26.12.2-2.52.1
Conditioned locomotion0.00.00.10.2-0.20.2
Cocaine response after cond. corrected0.91.02.00.7-1.40.8
Cocaine response after cond. not corrected0.40.40.90.4-1.00.4
Cocaine response before conditioning0.40.50.7-0.40.9-0.7
Saline control response2.63.54.4-1.91.6-2.1
Condit. Reinf. active minus inactive responses7.79.59.8-3.13.0-3.1
Condit. Reinf. active-inactive response ratio1.21.21.6-1.21.0-1.0
Condit. Reinf. active responses11.516.016.5-4.03.9-4.1
Condit. Reinf. inactive responses8.110.111.6-3.22.9-3.4
Condit. Reinf. lever presses21.830.130.3-5.45.5-5.5
Condit. Reinf. lever reinforcers received12.417.518.1-4.24.1-4.3
Pavlov. Cond. lever latency21.629.630.25.4-5.55.4
Pavlov. Cond. magazine entry latency4.85.57.3-2.22.7-2.1
Pavlov. Cond. change in total contacts14.420.120.6-4.54.4-4.5
Pavlov. Cond. index score16.421.423.1-4.64.8-4.5
Pavlov. Cond. latency score14.618.420.1-4.24.5-4.2
Pavlov. Cond. lever contacts22.631.532.8-5.55.7-5.5
Pavlov. Cond. magazine entry number7.69.39.93.1-3.12.9
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.40.1-0.5
Pavlov. Cond. lever-magazine prob. diff.15.520.121.1-4.54.6-4.4
Pavlov. Cond. response bias22.731.333.3-5.55.8-5.5
Conditioned reinforcement - actives1.31.31.7-1.31.0-1.1
Conditioned reinforcement - inactives0.40.40.90.3-1.00.5
Conditioned locomotion0.91.11.7-1.30.5-1.2
Intermittent access intake day 1-15 change1.11.11.3-1.10.9-1.1
Intermittent access intake escalation1.61.62.0-1.41.1-1.3
Intermittent access intake escalation 20.60.60.6-0.80.8-0.7
Intermitt. access day 1 inactive lever presses0.50.60.70.7-0.80.7
Intermitt. access day 15 inactive lever presses0.10.10.20.2-0.50.3
Intermitt. access escalation Index0.10.10.20.20.50.1
Intermittent access day 1 total infusions0.80.91.1-1.10.9-0.9
Intermittent access day 15 total infusions1.82.02.6-1.61.2-1.4
Intermittent access terminal intake (last 3 days)1.31.51.8-1.31.1-1.1
Intermittent access total infusions0.80.81.1-1.10.8-0.9
Intermittent access day 1 locomotion0.00.00.00.0-0.10.1
Intermittent access day 15 total locomotion1.41.52.0-1.40.8-1.3
Intermittent access total locomotion0.70.71.0-1.00.6-0.9
Intermittent access standard deviation0.20.20.2-0.50.2-0.4
Cocaine induced anxiety2.52.93.01.7-1.71.7
Post-drug Anxiety0.60.60.70.8-0.80.8
Baseline Anxiety2.52.62.8-1.71.6-1.6
Lifetime Intake1.01.11.5-1.20.9-1.0
Incentive Sensitization - Responses4.14.14.7-2.21.9-2.0
Incentive Sensitization - Breakpoint3.83.94.5-2.11.8-1.9
Progressive ratio test 1 active lever presses0.30.30.50.5-0.70.5
Progressive ratio test 1 breakpoint0.30.30.30.5-0.60.6
Progressive ratio test 1 inactive lever presses0.10.10.1-0.20.4-0.1
Progressive ratio test 2 active lever presses2.22.33.1-1.81.2-1.6
Progressive ratio test 2 breakpoint1.92.12.6-1.61.2-1.4
Progressive ratio test 2 inactive lever presses0.91.01.4-1.20.8-1.0
Total sessions with >9 infusions1.81.92.3-1.31.5-1.3
Short access day 1 total inactive lever presses0.20.20.5-0.2-0.70.0
Short access day 10 total inactive lever presses0.30.30.60.8-0.40.5
Short access day 1 total infusions2.72.83.0-1.71.6-1.7
Short access day 10 total infusions0.80.91.0-1.00.9-0.9
Short access total infusions0.70.80.9-0.91.0-0.8
Short access day 1 locomotion0.91.01.1-1.00.9-1.0
Short access day 10 total locomotion0.30.30.4-0.60.5-0.6
Short access total locomotion0.00.00.0-0.00.2-0.1
Compulsive drug intake0.00.00.0-0.0-0.0-0.1
One hour access (0.3 mA shock)2.32.73.4-1.81.5-1.6
One hour access (shock baseline)1.51.72.1-1.51.2-1.3
Number of responses in last shaping day0.20.20.7-0.20.8-0.2
Context. condit. distance diff. score1.72.14.5-1.12.1-0.8
Locomotion velocity, session 10.40.41.20.0-1.10.1
Locomotion distance, session 10.30.40.6-0.80.3-0.8
Locomotion velocity, session 20.50.50.8-0.8-0.4-0.9
Locomotion distance, session 20.30.40.7-0.70.2-0.8
Locomotion velocity, session 30.20.30.3-0.60.4-0.6
Locomotion distance, session 30.30.30.5-0.70.5-0.5
Stereotopy head waving bouts, day 30.10.10.20.4-0.50.1
Stereotopy head waving duration, day 30.20.20.4-0.40.4-0.6
Locomotion velocity, session 70.30.30.50.3-0.50.7
Locomotion distance, session 70.00.00.0-0.1-0.10.2
Stereotopy head waving bouts, day 71.01.11.4-1.00.9-1.2
Stereotopy head waving duration, day 72.12.63.0-1.71.4-1.7
Locomotion velocity, session 81.41.72.2-1.41.5-0.9
Locomotion distance, session 81.42.12.7-1.41.7-1.3
Degree of sensitization distance0.00.00.0-0.10.2-0.0
Degree of sensitization stereotypy2.62.93.2-1.81.5-1.8
Condit. Reinf. active minus inactive responses0.20.20.5-0.30.7-0.4
Condit. Reinf. active-inactive response ratio0.80.92.2-0.51.5-0.6
Condit. Reinf. active responses0.00.00.00.10.0-0.0
Condit. Reinf. inactive responses0.20.30.70.3-0.90.2
Incentive salience index mean0.20.20.4-0.40.6-0.3
Condit. Reinf. lever presses0.10.10.2-0.40.2-0.2
Time in familiar zone, hab. session 10.10.10.20.3-0.20.4
Time in novel zone, hab. session 10.00.00.0-0.0-0.1-0.1
Total zone transitions, hab. session 10.00.10.10.40.10.1
Total locomotion distance, hab. session 10.50.71.41.2-0.50.7
Locomotion velocity, hab. session 10.30.51.11.0-0.30.5
Time in familiar zone, hab. session 21.31.42.3-1.01.5-0.9
Time in novel zone, hab. session 20.40.41.20.2-1.10.1
Total zone transitions, hab. session 20.50.61.1-0.51.0-0.7
Total locomotion distance, hab. session 20.10.10.30.60.20.2
Locomotion velocity, hab. session 20.10.20.40.60.10.2
Novel to familiar place preference ratio0.10.10.2-0.30.1-0.4
Novelty place preference0.10.10.2-0.3-0.1-0.4
Time in novel zone, NPP test0.20.20.3-0.50.1-0.6
Total zone transitions, NPP test0.00.00.0-0.0-0.1-0.0
Total locomotion distance, NPP test0.60.81.01.0-1.00.8
Locomotion velocity, NPP test1.01.41.71.3-1.31.0
Pavlov. Cond. lever latency1.31.61.71.3-1.31.1
Pavlov. Cond. magazine entry latency3.14.15.4-1.92.3-1.8
Pavlov. Cond. change in total contacts1.01.11.4-1.20.9-1.0
Pavlov. Cond. index score3.34.24.6-2.12.2-1.9
Pavlov. Cond. latency score3.13.94.6-2.02.1-1.8
Pavlov. Cond. lever contacts1.31.51.9-1.41.2-1.2
Pavlov. Cond. magazine entry number3.64.65.52.1-2.32.0
Pavlov. Cond. intertrial magazine entries2.12.54.41.2-2.11.2
Pavlov. Cond. lever-magazine prob. diff.2.63.23.7-1.81.9-1.6
Pavlov. Cond. response bias1.11.41.5-1.21.2-1.1
Bone: apparent density0.20.40.60.80.10.7
Bone surface1.32.33.8-1.32.0-1.2
Bone volume0.61.11.9-0.91.4-0.8
Bone: connectivity density0.20.20.40.40.60.4
Bone: cortical apparent density0.70.91.10.9-1.10.8
Bone: cortical area0.71.12.1-0.71.4-0.8
Bone: cortical porosity0.80.91.2-1.00.7-1.1
Bone: cortical porosity0.50.50.8-0.80.3-0.9
Bone: cortical thickness0.20.30.40.7-0.20.7
Bone: cortical thickness0.10.10.3-0.50.3-0.3
Bone: cortical tissue density0.70.91.30.9-1.10.9
Bone: elastic displacement2.02.22.81.5-1.31.7
Bone: elastic work2.43.24.11.8-1.52.0
Bone: endosteal estimation1.94.04.7-2.02.2-1.9
Bone: endosteal perimeter2.85.86.3-2.42.5-2.3
Bone: final force0.10.10.30.20.60.2
Bone: final moment0.10.20.6-0.10.8-0.0
Bone: marrow area1.63.44.1-1.82.0-1.7
Bone: maximum diameter2.95.36.9-2.22.6-2.1
Bone: maximum force0.20.31.0-0.11.00.0
Bone: maximum moment0.30.61.5-0.31.2-0.2
Bone: minimum diameter0.61.21.9-0.91.4-0.9
Bone: periosteal estimation1.93.94.9-1.92.2-1.8
Bone: periosteal perimeter2.43.94.9-1.92.2-1.8
Bone: post-yield work0.40.51.4-0.21.2-0.3
Bone: stiffness0.10.20.30.50.30.5
Bone: tissue strength1.11.11.61.3-0.51.2
Bone: trabecular number1.62.43.51.8-0.81.9
Bone: trabecular spacing1.11.42.1-1.30.7-1.5
Bone: trabecular thickness0.10.10.20.4-0.00.4
Bone: trabecular tissue density0.30.40.60.6-0.70.3
Breakpoint value in progressive ratio session0.30.30.50.5-0.70.6
Distance traveled before self-admin0.40.40.50.7-0.60.7
Distance traveled after self-admin2.12.33.01.4-1.71.3
Delta time in closed arm before/after self-admin0.00.00.10.0-0.20.2
Delta time in open arm before/after self-admin2.92.73.1-1.61.8-1.6
Diff in mean of infusions in LGA sessions3.33.63.81.9-1.91.9
Extinction: sum of active levers before priming0.10.10.2-0.3-0.5-0.2
Active lever presses in extinction session 61.71.61.9-1.21.3-1.4
Delta distance traveled before/after self-admin0.10.10.10.1-0.40.1
Delta ambulatory time before/after self-admin0.10.10.30.3-0.50.3
Time in closed arm before self-admin0.20.20.3-0.50.5-0.5
Time in closed arm after self-admin0.70.71.00.6-1.00.9
Time in open arm before self-admin2.72.93.01.7-1.71.7
Time in open arm after self-admin0.60.71.5-0.41.2-0.7
Sum of active levers in priming session hrs 5-60.10.10.1-0.1-0.3-0.2
Time to tail flick, vehicle, before self-admin0.30.30.40.60.00.6
Time to tail flick, vehicle, after self-admin1.31.41.7-1.21.3-1.1
Time to tail flick, test, before self-admin0.20.20.2-0.40.5-0.4
Time to tail flick, test, after self-admin0.80.81.1-1.00.6-0.9
Delta time to tail flick, vehicle, before/after SA1.61.62.0-1.41.1-1.3
Delta time to tail flick, test, before/after SA0.10.10.20.2-0.40.2
Ambulatory time before self-admin0.70.70.80.8-0.90.8
Ambulatory time after self-admin2.12.33.61.3-1.91.3
Total heroin consumption0.00.10.1-0.20.4-0.2
Area under the delay curve0.10.10.2-0.4-0.1-0.2
Delay disc. indifference point, 0s delay0.80.91.2-1.10.5-1.1
Delay disc. indifference point, 16s delay0.10.10.30.1-0.50.3
Delay disc. indifference point, 2s delay1.11.21.5-1.20.8-1.2
Delay disc. indifference point, 24s delay0.80.81.00.8-0.81.0
Delay disc. indifference point, 4s delay1.21.32.2-1.50.2-1.3
Delay disc. indifference point, 8s delay0.20.20.3-0.50.5-0.3
Delay discount exponential model param0.10.10.10.30.20.1
Delay discount hyperbolic model param0.20.20.40.6-0.00.4
Fecal boli incidents, locomotor time 10.50.50.8-0.90.6-0.7
Change in fecal boli incidents, locomotor task1.51.41.81.2-1.31.1
Time >=10cm from walls, locomotor time 10.90.90.9-0.91.0-0.9
Bouts of movement, locomotor time 10.10.10.2-0.4-0.1-0.5
Total resting periods, locomotor time 10.10.10.2-0.1-0.4-0.1
Rest time, locomotor task time 10.50.61.50.2-1.20.3
Distance moved, locomotor task time 11.01.11.9-0.91.4-0.8
Vertical activity count, locomotor time 11.31.42.9-0.81.7-0.8
Time >=10cm from walls, locomotor time 21.11.21.7-1.20.8-1.3
Bouts of movement, locomotor time 20.91.01.3-1.10.6-1.1
Total resting periods, locomotor time 20.40.50.7-0.80.3-0.8
Rest time, locomotor task time 22.63.03.31.8-1.71.7
Distance moved, locomotor task time 23.94.65.2-2.32.0-2.2
Vertical activity count, locomotor time 22.42.73.2-1.61.8-1.5
Weight adjusted by age1.11.31.5-1.21.0-1.2
Seeking ratio, delayed vs. immediate footshock2.02.32.71.3-1.71.5
Locomotion in novel chamber0.50.70.8-0.80.7-0.9
Locomotion in novel chamber post-restriction2.12.52.8-1.71.4-1.7
Progressive ratio0.00.00.0-0.00.00.1
Food seeking constrained by brief footshock2.22.73.5-1.61.5-1.9
Seeking ratio, punishment vs. effort1.31.62.1-1.21.2-1.4
Run reversals in cocaine runway, females0.10.10.4-0.20.6-0.1
Run reversals in cocaine runway, males0.00.00.1-0.2-0.00.1
Latency to leave start box in cocaine runway2.02.22.41.5-1.61.4
Latency to leave start box in cocaine runway, F1.21.31.41.1-1.21.1
Latency to leave start box in cocaine runway, M0.80.81.01.0-0.70.9
Cd content in liver0.50.60.80.9-0.40.9
Co content in liver1.41.61.8-1.31.2-1.2
Cu content in liver1.01.31.8-1.30.6-1.3
Fe content in liver0.00.00.0-0.2-0.10.1
K content in liver0.10.10.10.4-0.30.4
Mg content in liver0.20.20.2-0.40.4-0.4
Mn content in liver2.12.42.81.4-1.71.5
Na content in liver0.10.10.1-0.30.3-0.4
Rb content in liver1.11.41.8-1.11.4-1.1
Se content in liver5.87.08.72.4-3.02.5
Sr content in liver0.00.00.1-0.0-0.30.1
Zn content in liver5.96.56.7-2.62.5-2.6