Hub : Genes

Idh1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	isoform ratio	ENSRNOT00000020322	0.07	0.05	5.3e-03	0.03	0.01	0.01	0.02	4.1e-04	1.8e-02	9.5e-03	3.5e-03
2	Adipose	isoform ratio	ENSRNOT00000108404	0.07	0.05	5.1e-03	0.03	0.01	0.01	0.02	2.8e-04	1.7e-02	7.0e-03	1.7e-03
3	Brain	gene expression	ENSRNOG00000015020	0.02	0.02	3.7e-03	0.02	0.01	-0	0.01	4.1e-03	1.3e-02	4.4e-01	3.4e-02
4	Liver	isoform ratio	ENSRNOT00000020322	0.03	0.02	2.8e-03	0	0	-0	-0	3.4e-01	9.8e-02	6.0e-01	5.1e-01
5	Liver	isoform ratio	ENSRNOT00000108404	0.03	0.02	2.1e-03	0	0.01	-0	0	3.0e-01	6.4e-02	4.3e-01	2.9e-01
6	PL	mRNA stability	ENSRNOG00000015020	0.03	0.02	7.1e-03	0.01	0	-0	0	5.1e-02	2.9e-01	6.6e-01	3.5e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
BMI with tail	6.3	20.4	31.6	-1.2	1.2	5.3	-5.6	5.6	-5.3
BMI without tail	4.1	8.6	12.5	-1.9	1.9	3.1	-3.5	3.5	-3.1
Body weight	0.3	1.2	1.9	-0.6	0.6	1.0	-1.4	1.3	-1.4
Epididymis fat weight	0.1	0.2	0.4	0.6	-0.6	-0.3	0.4	-0.4	0.0
Glucose	0.5	0.7	1.2	0.2	-0.2	1.1	-1.0	1.0	-1.1
Heart weight	0.4	0.5	1.0	0.5	-0.5	-0.9	1.0	-0.9	0.4
Left kidney weight	0.1	0.2	0.4	0.7	-0.7	0.2	-0.0	0.1	-0.4
Right kidney weight	0.0	0.0	0.1	0.2	-0.2	-0.1	0.1	-0.1	-0.3
Tail length	3.1	9.3	16.0	-0.8	0.8	-4.0	3.5	-3.6	3.7
Length with tail	3.9	14.1	24.1	-0.5	0.5	-4.9	4.5	-4.6	4.4
Length without tail	1.5	3.3	4.7	1.2	-1.2	-2.1	2.2	-2.2	1.8
Liver weight, left	1.2	2.0	2.8	-1.2	1.2	-1.7	1.4	-1.5	1.4
Liver weight, right	0.3	0.5	0.9	-0.3	0.3	-0.9	0.8	-0.8	0.9
Parametrial fat weight	0.2	0.4	0.7	-0.6	0.6	-0.8	0.4	-0.5	0.7
Retroperitoneal fat weight	0.4	1.4	2.0	0.8	-0.8	1.4	-1.3	1.3	-1.2
Intraocular pressure	2.1	2.9	4.8	-0.5	0.5	1.9	-2.2	2.2	-2.0
Extensor digitorum longus weight	1.9	7.7	11.5	-1.5	1.5	3.0	-3.4	3.4	-3.0
Soleus weight	0.5	1.5	3.4	-1.8	1.8	0.6	-1.0	0.9	-0.5
Tibialis anterior weight	0.5	1.6	2.5	-0.5	0.5	1.5	-1.6	1.6	-1.5
Tibia length	1.2	3.3	5.2	-0.0	0.0	-2.3	2.1	-2.2	2.2
Number of licking bursts	0.5	0.5	1.5	1.2	-1.2	0.4	-0.1	0.1	-0.4
Food consumed during 24 hour testing period	0.4	0.5	0.8	-0.5	0.5	-0.7	0.7	-0.7	0.9
Times rat made contact with spout	0.6	0.7	1.2	0.2	-0.2	-0.9	1.1	-1.1	1.0
Mean time between licks in bursts	0.3	0.4	0.8	-0.2	0.2	0.6	-0.9	0.9	-0.7
Mean num. licks in bursts	0.4	0.5	0.7	-0.9	0.9	-0.7	0.5	-0.5	0.7
Std. dev. time between licks in bursts	2.8	3.3	5.7	-0.9	0.9	2.0	-2.4	2.4	-1.7
Water consumed over 24 hours	0.1	0.1	0.3	0.2	-0.2	0.5	-0.4	0.4	-0.3
Indifference point 0 sec	0.7	1.1	1.9	-0.6	0.6	1.1	-1.4	1.4	-1.1
Indifference point AUC	0.3	0.3	0.6	0.7	-0.7	-0.3	0.4	-0.4	0.8
Indifference point function ln k	1.1	1.6	2.8	-0.6	0.6	1.4	-1.4	1.5	-1.7
Indifference point function log k	1.1	1.6	2.8	-0.6	0.6	1.4	-1.4	1.5	-1.7
Delay discounting total patch changes 0 sec	0.6	0.9	1.5	-0.4	0.4	1.0	-1.2	1.2	-1.0
Delay discounting total patch changes 12 sec	1.0	1.4	3.9	2.0	-2.0	0.1	0.4	-0.4	0.3
Delay discounting total patch changes 18 sec	0.4	0.6	1.1	0.1	-0.1	1.0	-1.0	1.1	-0.7
Delay discounting total patch changes 24 sec	0.2	0.2	0.6	0.8	-0.8	0.3	-0.2	0.2	-0.1
Delay discounting total patch changes 6 sec	0.9	1.3	2.1	-0.5	0.5	1.4	-1.4	1.4	-1.1
Delay discounting time to switch 0 sec	0.1	0.1	0.3	-0.6	0.6	-0.1	0.2	-0.2	0.0
Delay discounting water rate 0 sec	0.2	0.3	0.6	0.8	-0.8	0.4	-0.5	0.5	-0.4
Delay discounting water rate 12 sec	0.5	0.7	0.9	-0.9	0.9	0.6	-0.8	0.8	-0.7
Delay discounting water rate 18 sec	0.5	0.7	1.1	0.5	-0.5	-1.0	1.1	-1.0	0.7
Delay discounting water rate 24 sec	0.1	0.2	0.4	-0.6	0.6	-0.2	-0.2	0.2	0.0
Delay discounting water rate 6 sec	1.1	1.6	2.7	-0.3	0.3	1.4	-1.6	1.6	-1.4
Locomotor activity	0.1	0.2	0.5	0.7	-0.7	-0.0	0.2	-0.1	-0.0
Locomotor testing distance	0.0	0.1	0.1	0.4	-0.4	-0.2	-0.0	0.1	-0.4
Locomotor testing rearing	0.1	0.1	0.3	0.5	-0.5	-0.3	0.3	-0.3	-0.1
Light reinforcement 1	1.2	2.2	3.4	0.5	-0.5	1.8	-1.7	1.7	-1.8
Light reinforcement 2	0.5	0.7	1.1	-0.2	0.2	-1.1	1.0	-1.1	0.9
Reaction time number correct	0.3	0.4	0.5	-0.6	0.6	0.6	-0.6	0.7	-0.7
Reaction time mean minus median	0.1	0.1	0.2	-0.5	0.5	0.2	-0.3	0.3	-0.3
Reaction time mean minus median AUC	0.3	0.4	1.3	-1.1	1.1	-0.2	-0.1	0.0	0.1
Reaction time num false alarms	2.8	3.9	6.2	0.9	-0.9	2.4	-2.2	2.2	-2.5
Reaction time num false alarms AUC	2.5	3.5	5.4	-0.0	0.0	2.2	-2.3	2.3	-2.3
Reaction time trials correct on left	0.3	0.4	0.5	-0.6	0.6	0.6	-0.6	0.7	-0.7
Reaction time trials on left	0.3	0.4	0.5	-0.6	0.6	0.6	-0.6	0.7	-0.7
Reaction time mean	2.2	3.1	4.9	-0.0	0.0	-2.2	2.2	-2.2	2.0
Reaction time mean AUC	1.7	2.3	3.8	-0.1	0.1	-1.9	1.9	-1.9	1.7
Median of all reaction times	3.5	4.7	7.4	0.2	-0.2	-2.7	2.7	-2.7	2.5
Reaction time omissions	0.2	0.2	0.5	-0.7	0.7	-0.0	-0.3	0.3	-0.2
Reaction time false alarm rate	1.2	1.6	2.5	0.5	-0.5	1.5	-1.6	1.5	-1.6
Reaction time premature initiation rate	0.2	0.2	0.4	-0.3	0.3	-0.4	0.5	-0.5	0.6
Reaction time premature initiations	0.2	0.2	0.7	-0.9	0.9	0.1	-0.0	0.1	0.1
Std. dev. reaction times	0.3	0.4	0.7	-0.1	0.1	-0.8	0.8	-0.8	0.6
Reaction time trials completed	0.3	0.4	0.5	-0.6	0.6	0.6	-0.6	0.7	-0.7
Reaction time trials AUC	0.2	0.3	0.4	-0.7	0.7	0.5	-0.5	0.6	-0.5
Social response proportion	0.3	0.3	0.4	-0.7	0.7	-0.6	0.3	-0.4	0.4
Social responses	0.2	0.3	0.5	-0.0	0.0	-0.7	0.7	-0.7	0.7
Social time	0.5	0.7	1.2	-1.1	1.1	-0.6	0.6	-0.6	0.6
Conditioned locomotion	1.3	1.6	3.3	-1.8	1.8	-0.9	0.5	-0.6	1.2
Cocaine response after cond. corrected	1.7	1.9	4.4	-2.1	2.1	-1.0	0.4	-0.4	1.0
Cocaine response after cond. not corrected	1.6	1.7	2.7	-1.6	1.6	-1.4	0.9	-0.9	1.3
Cocaine response before conditioning	1.3	1.6	4.0	2.0	-2.0	-0.4	0.9	-0.9	0.1
Saline control response	1.7	2.3	3.2	-1.8	1.8	1.2	-1.5	1.5	-1.2
Condit. Reinf. active minus inactive responses	5.8	7.1	11.6	-1.1	1.1	-3.3	3.0	-3.0	3.4
Condit. Reinf. active-inactive response ratio	5.3	5.5	9.2	-0.4	0.4	-2.9	2.7	-2.8	3.0
Condit. Reinf. active responses	3.6	5.0	8.2	-1.0	1.0	-2.7	2.5	-2.5	2.9
Condit. Reinf. inactive responses	0.2	0.2	0.3	-0.5	0.5	-0.4	0.5	-0.5	0.4
Condit. Reinf. lever presses	0.7	0.9	1.4	-0.6	0.6	-1.1	1.1	-1.0	1.2
Condit. Reinf. lever reinforcers received	3.9	5.5	8.8	-1.1	1.1	-2.8	2.6	-2.6	3.0
Pavlov. Cond. lever latency	1.0	1.3	2.1	0.2	-0.2	1.4	-1.5	1.4	-1.3
Pavlov. Cond. magazine entry latency	0.4	0.4	0.7	0.6	-0.6	-0.6	0.8	-0.8	0.4
Pavlov. Cond. change in total contacts	1.2	1.7	2.3	-1.2	1.2	-1.5	1.3	-1.3	1.4
Pavlov. Cond. index score	1.3	1.7	2.8	-0.1	0.1	-1.6	1.7	-1.7	1.5
Pavlov. Cond. latency score	1.2	1.5	2.6	0.0	-0.0	-1.5	1.6	-1.6	1.4
Pavlov. Cond. lever contacts	1.7	2.4	3.8	-0.2	0.2	-1.8	2.0	-1.9	1.8
Pavlov. Cond. magazine entry number	0.9	1.1	1.7	-1.0	1.0	1.0	-1.3	1.2	-0.8
Pavlov. Cond. intertrial magazine entries	2.1	2.7	4.0	-1.2	1.2	1.6	-2.0	1.9	-1.8
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	2.4	-0.1	0.1	-1.5	1.6	-1.5	1.4
Pavlov. Cond. response bias	1.6	2.2	3.6	-0.1	0.1	-1.8	1.9	-1.9	1.7
Conditioned reinforcement - actives	0.3	0.3	0.6	-0.3	0.3	0.5	-0.8	0.8	-0.5
Conditioned reinforcement - inactives	1.3	1.5	3.3	-0.5	0.5	-1.5	1.1	-1.2	1.8
Conditioned locomotion	4.4	5.2	8.3	0.5	-0.5	2.8	-2.7	2.7	-2.9
Intermittent access intake day 1-15 change	0.1	0.1	0.2	-0.4	0.4	0.2	-0.2	0.1	0.2
Intermittent access intake escalation	0.0	0.0	0.1	-0.2	0.2	0.1	-0.0	0.0	0.3
Intermittent access intake escalation 2	0.2	0.2	0.6	-0.5	0.5	-0.1	0.2	-0.2	0.8
Intermitt. access day 1 inactive lever presses	0.4	0.4	1.1	1.0	-1.0	-0.4	0.3	-0.3	0.1
Intermitt. access day 15 inactive lever presses	0.7	0.8	1.4	0.3	-0.3	-1.0	1.1	-1.1	1.2
Intermitt. access escalation Index	3.0	2.6	5.2	2.3	-2.3	1.6	-0.7	0.8	-1.4
Intermittent access day 1 total infusions	0.1	0.1	0.3	-0.5	0.5	0.2	-0.4	0.4	-0.2
Intermittent access day 15 total infusions	0.2	0.2	0.4	-0.0	0.0	0.6	-0.6	0.6	-0.5
Intermittent access terminal intake (last 3 days)	0.4	0.4	0.7	-0.1	0.1	0.8	-0.7	0.8	-0.8
Intermittent access total infusions	0.1	0.1	0.1	-0.3	0.3	0.2	-0.4	0.4	-0.2
Intermittent access day 1 locomotion	0.3	0.3	0.8	0.9	-0.9	0.2	-0.1	0.1	-0.3
Intermittent access day 15 total locomotion	0.5	0.5	1.5	1.2	-1.2	0.2	0.1	-0.0	-0.1
Intermittent access total locomotion	0.6	0.7	1.0	0.8	-0.8	0.9	-0.7	0.7	-1.0
Intermittent access standard deviation	0.8	0.8	2.3	0.1	-0.1	-0.9	1.0	-1.0	1.5
Cocaine induced anxiety	0.5	0.6	0.7	-0.6	0.6	0.8	-0.8	0.8	-0.8
Post-drug Anxiety	0.7	0.8	1.0	-0.8	0.8	0.8	-1.0	1.0	-0.7
Baseline Anxiety	0.9	0.9	1.7	-1.3	1.3	-0.9	0.4	-0.4	1.0
Lifetime Intake	0.4	0.5	0.7	-0.7	0.7	0.5	-0.8	0.8	-0.6
Incentive Sensitization - Responses	0.1	0.1	0.1	-0.4	0.4	-0.2	0.1	-0.1	0.2
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	-0.4	0.4	-0.1	0.1	-0.1	0.2
Progressive ratio test 1 active lever presses	0.5	0.5	1.1	1.1	-1.1	0.5	-0.2	0.2	-0.7
Progressive ratio test 1 breakpoint	0.8	0.8	2.1	1.4	-1.4	0.4	0.1	-0.0	-0.7
Progressive ratio test 1 inactive lever presses	1.2	1.3	2.2	0.8	-0.8	1.2	-1.2	1.2	-1.5
Progressive ratio test 2 active lever presses	0.1	0.1	0.1	-0.0	0.0	0.3	-0.3	0.3	-0.4
Progressive ratio test 2 breakpoint	0.0	0.0	0.1	-0.3	0.3	0.1	-0.1	0.1	-0.1
Progressive ratio test 2 inactive lever presses	0.3	0.3	0.8	0.9	-0.9	0.4	-0.3	0.3	-0.1
Total sessions with >9 infusions	0.4	0.5	1.3	-1.1	1.1	-0.0	-0.4	0.4	-0.2
Short access day 1 total inactive lever presses	0.4	0.5	1.3	1.1	-1.1	0.4	-0.3	0.3	-0.0
Short access day 10 total inactive lever presses	1.9	2.1	2.2	1.5	-1.5	-1.3	1.5	-1.5	1.4
Short access day 1 total infusions	0.3	0.3	0.5	-0.3	0.3	0.6	-0.6	0.6	-0.7
Short access day 10 total infusions	0.6	0.7	2.0	-1.4	1.4	-0.3	-0.0	0.0	0.4
Short access total infusions	1.2	1.3	1.9	-1.4	1.4	0.7	-1.2	1.2	-0.8
Short access day 1 locomotion	0.8	0.8	1.1	0.7	-0.7	-0.9	1.0	-1.0	1.0
Short access day 10 total locomotion	0.3	0.3	0.6	0.5	-0.5	-0.7	0.8	-0.7	0.1
Short access total locomotion	0.0	0.0	0.1	-0.0	0.0	0.3	-0.3	0.3	-0.3
Compulsive drug intake	0.2	0.2	0.5	0.3	-0.3	-0.4	0.4	-0.3	0.7
One hour access (0.3 mA shock)	0.3	0.3	0.7	0.8	-0.8	-0.3	0.4	-0.4	0.4
One hour access (shock baseline)	0.0	0.0	0.1	0.2	-0.2	-0.0	0.0	-0.0	-0.1
Number of responses in last shaping day	0.5	0.5	1.0	0.1	-0.1	-1.0	0.9	-0.9	0.6
Context. condit. distance diff. score	1.0	1.2	2.7	1.6	-1.6	0.9	-0.3	0.3	-0.8
Locomotion velocity, session 1	1.5	1.7	3.3	-1.8	1.8	-1.1	0.5	-0.5	1.3
Locomotion distance, session 1	1.0	1.3	3.2	-1.8	1.8	0.3	-0.7	0.7	0.4
Locomotion velocity, session 2	1.6	1.9	5.1	-2.3	2.3	0.2	-0.7	0.7	0.1
Locomotion distance, session 2	1.3	1.8	3.5	-1.9	1.9	0.8	-1.3	1.3	-0.2
Locomotion velocity, session 3	0.3	0.3	0.7	0.3	-0.3	0.8	-0.5	0.5	-0.8
Locomotion distance, session 3	1.2	1.3	2.1	0.5	-0.5	-1.1	1.4	-1.4	1.4
Stereotopy head waving bouts, day 3	1.7	2.0	3.2	-0.2	0.2	1.7	-1.8	1.8	-1.7
Stereotopy head waving duration, day 3	2.3	2.8	4.1	-0.9	0.9	1.8	-2.0	2.0	-2.0
Locomotion velocity, session 7	0.0	0.0	0.1	0.1	-0.1	0.2	-0.2	0.2	-0.2
Locomotion distance, session 7	0.2	0.3	0.6	-0.8	0.8	-0.2	-0.1	0.0	0.5
Stereotopy head waving bouts, day 7	0.1	0.2	0.3	0.2	-0.2	0.5	-0.4	0.4	-0.6
Stereotopy head waving duration, day 7	1.0	1.3	2.3	0.6	-0.6	1.4	-1.1	1.1	-1.5
Locomotion velocity, session 8	0.1	0.1	0.2	0.1	-0.1	0.5	-0.2	0.2	-0.3
Locomotion distance, session 8	0.2	0.3	0.6	0.3	-0.3	0.8	-0.6	0.6	-0.3
Degree of sensitization distance	1.7	1.7	2.2	-1.5	1.5	0.9	-1.5	1.4	-0.8
Degree of sensitization stereotypy	0.3	0.3	0.6	0.3	-0.3	0.7	-0.5	0.5	-0.8
Condit. Reinf. active minus inactive responses	1.5	1.7	2.2	1.3	-1.3	-1.2	1.5	-1.4	1.1
Condit. Reinf. active-inactive response ratio	0.7	0.8	1.7	1.3	-1.3	-0.5	0.7	-0.6	0.3
Condit. Reinf. active responses	2.0	2.4	3.3	1.4	-1.4	-1.5	1.8	-1.7	1.4
Condit. Reinf. inactive responses	0.6	0.7	1.1	0.1	-0.1	-1.0	1.0	-1.0	1.0
Incentive salience index mean	2.0	2.3	2.9	1.7	-1.7	-1.2	1.7	-1.6	1.2
Condit. Reinf. lever presses	1.4	1.9	2.7	1.6	-1.6	-1.0	1.4	-1.4	1.0
Time in familiar zone, hab. session 1	1.6	1.5	2.3	-0.4	0.4	1.5	-1.5	1.5	-1.4
Time in novel zone, hab. session 1	4.8	4.6	7.1	-0.4	0.4	-2.7	2.6	-2.6	2.6
Total zone transitions, hab. session 1	0.7	0.9	2.0	-1.4	1.4	-0.7	0.2	-0.3	1.0
Total locomotion distance, hab. session 1	1.1	1.5	3.0	-0.7	0.7	-1.4	1.3	-1.3	1.7
Locomotion velocity, hab. session 1	0.8	1.2	2.4	-0.3	0.3	-1.3	1.1	-1.2	1.5
Time in familiar zone, hab. session 2	0.7	0.7	1.5	1.2	-1.2	0.7	-0.3	0.3	-0.6
Time in novel zone, hab. session 2	1.1	1.2	3.2	-1.8	1.8	-0.5	0.1	-0.1	0.4
Total zone transitions, hab. session 2	0.5	0.7	1.9	-1.4	1.4	0.1	-0.4	0.4	0.4
Total locomotion distance, hab. session 2	0.1	0.1	0.2	-0.5	0.5	-0.1	-0.0	0.0	0.5
Locomotion velocity, hab. session 2	0.1	0.1	0.2	-0.3	0.3	-0.1	-0.1	0.0	0.5
Novel to familiar place preference ratio	1.1	1.2	1.7	-1.3	1.3	-1.1	0.7	-0.7	1.2
Novelty place preference	1.2	1.3	1.7	-1.3	1.3	-1.2	0.8	-0.8	1.3
Time in novel zone, NPP test	1.3	1.4	1.9	-1.2	1.2	-1.3	0.9	-1.0	1.4
Total zone transitions, NPP test	0.2	0.3	0.6	-0.8	0.8	0.0	-0.2	0.1	0.6
Total locomotion distance, NPP test	0.2	0.3	0.9	-0.7	0.7	-0.3	0.2	-0.2	1.0
Locomotion velocity, NPP test	0.1	0.2	0.4	-0.6	0.6	-0.0	-0.2	0.1	0.6
Pavlov. Cond. lever latency	0.0	0.0	0.0	0.2	-0.2	0.2	-0.1	0.1	-0.1
Pavlov. Cond. magazine entry latency	1.3	1.7	2.6	1.6	-1.6	-0.9	1.3	-1.3	0.8
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.3	-0.3	0.2	-0.3	0.3	-0.4
Pavlov. Cond. index score	0.3	0.4	0.7	0.3	-0.3	-0.7	0.8	-0.8	0.6
Pavlov. Cond. latency score	0.2	0.3	0.5	0.3	-0.3	-0.7	0.7	-0.7	0.5
Pavlov. Cond. lever contacts	0.0	0.0	0.1	-0.3	0.3	-0.2	0.2	-0.2	0.2
Pavlov. Cond. magazine entry number	0.3	0.4	0.7	-0.2	0.2	0.8	-0.8	0.7	-0.6
Pavlov. Cond. intertrial magazine entries	0.6	0.7	2.0	-1.4	1.4	0.1	-0.3	0.3	0.0
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.8	0.6	-0.6	-0.7	0.9	-0.9	0.6
Pavlov. Cond. response bias	0.4	0.5	0.8	0.2	-0.2	-0.9	0.9	-0.9	0.7
Bone: apparent density	0.6	1.0	2.0	1.4	-1.4	-0.4	0.9	-0.9	0.2
Bone surface	0.4	0.7	1.0	1.0	-1.0	-0.5	1.0	-0.9	0.7
Bone volume	1.5	2.5	3.2	1.8	-1.8	-1.1	1.7	-1.7	1.2
Bone: connectivity density	0.4	0.7	1.1	0.8	-0.8	1.0	-0.6	0.6	-1.1
Bone: cortical apparent density	2.4	3.1	4.9	-0.0	0.0	2.1	-2.2	2.2	-2.1
Bone: cortical area	1.0	1.6	1.9	1.4	-1.4	-1.1	1.3	-1.3	1.1
Bone: cortical porosity	7.2	7.7	12.6	0.8	-0.8	-3.3	3.5	-3.6	3.0
Bone: cortical porosity	8.0	8.6	14.1	0.6	-0.6	-3.5	3.7	-3.7	3.3
Bone: cortical thickness	0.4	0.6	1.3	1.2	-1.2	-0.4	0.6	-0.6	0.4
Bone: cortical thickness	1.4	1.7	2.7	0.4	-0.4	-1.4	1.7	-1.6	1.5
Bone: cortical tissue density	2.7	3.5	5.6	-0.2	0.2	2.2	-2.3	2.4	-2.2
Bone: elastic displacement	0.3	0.3	0.6	0.8	-0.8	0.5	-0.1	0.1	-0.5
Bone: elastic work	1.6	2.0	3.9	2.0	-2.0	-0.8	1.3	-1.3	0.7
Bone: endosteal estimation	1.4	2.9	4.5	0.9	-0.9	-1.8	2.1	-2.1	1.9
Bone: endosteal perimeter	0.7	1.5	2.1	1.0	-1.0	-1.2	1.5	-1.4	1.1
Bone: final force	2.3	3.8	4.5	2.1	-2.1	-1.6	2.1	-2.1	1.5
Bone: final moment	1.6	2.7	3.2	1.8	-1.8	-1.3	1.8	-1.8	1.2
Bone: marrow area	1.3	2.8	4.3	0.8	-0.8	-1.8	2.1	-2.0	1.9
Bone: maximum diameter	1.1	2.0	2.7	1.0	-1.0	-1.5	1.6	-1.6	1.5
Bone: maximum force	1.7	2.9	4.7	2.2	-2.2	-1.1	1.7	-1.7	1.1
Bone: maximum moment	1.1	1.9	3.4	1.8	-1.8	-0.8	1.3	-1.3	0.7
Bone: minimum diameter	1.8	3.3	4.8	1.4	-1.4	-1.8	2.2	-2.2	1.8
Bone: periosteal estimation	1.8	3.7	5.4	1.4	-1.4	-2.0	2.3	-2.3	2.0
Bone: periosteal perimeter	1.5	2.5	3.7	1.0	-1.0	-1.7	1.9	-1.9	1.7
Bone: post-yield work	0.2	0.3	0.8	0.9	-0.9	-0.1	0.3	-0.3	0.0
Bone: stiffness	1.0	1.6	2.3	1.5	-1.5	-0.9	1.3	-1.3	0.9
Bone: tissue strength	0.3	0.3	0.6	0.8	-0.8	0.3	-0.2	0.2	-0.5
Bone: trabecular number	0.5	0.8	2.1	1.5	-1.5	0.6	-0.0	0.0	-0.7
Bone: trabecular spacing	0.2	0.3	0.6	-0.6	0.6	-0.8	0.4	-0.4	0.5
Bone: trabecular thickness	1.3	1.5	3.1	1.8	-1.8	-0.6	1.0	-1.0	0.7
Bone: trabecular tissue density	0.4	0.6	1.2	0.5	-0.5	-1.1	0.8	-0.8	1.0
Breakpoint value in progressive ratio session	2.1	2.4	4.5	2.1	-2.1	-0.8	1.4	-1.3	1.0
Distance traveled before self-admin	2.3	2.4	3.8	0.3	-0.3	-1.9	2.0	-2.0	1.8
Distance traveled after self-admin	2.4	2.6	7.7	2.8	-2.8	0.3	0.3	-0.2	-0.0
Delta time in closed arm before/after self-admin	1.5	1.5	1.8	-1.3	1.3	1.0	-1.3	1.2	-1.1
Delta time in open arm before/after self-admin	2.6	2.5	3.9	0.3	-0.3	-1.8	2.0	-2.0	1.9
Diff in mean of infusions in LGA sessions	0.6	0.6	1.4	1.2	-1.2	0.6	-0.2	0.3	-0.7
Extinction: sum of active levers before priming	2.2	2.2	6.5	2.5	-2.5	0.4	0.3	-0.3	-0.3
Active lever presses in extinction session 6	0.2	0.2	0.3	0.4	-0.4	-0.5	0.5	-0.5	0.5
Delta distance traveled before/after self-admin	3.0	3.2	5.4	2.3	-2.3	1.8	-1.2	1.3	-1.5
Delta ambulatory time before/after self-admin	2.4	2.6	4.2	2.1	-2.1	1.6	-1.2	1.2	-1.3
Time in closed arm before self-admin	2.9	3.3	4.6	2.1	-2.1	-1.4	1.9	-1.9	1.2
Time in closed arm after self-admin	0.3	0.3	0.6	0.8	-0.8	-0.4	0.5	-0.5	0.3
Time in open arm before self-admin	3.2	3.4	4.7	-1.7	1.7	1.7	-2.2	2.2	-1.6
Time in open arm after self-admin	0.6	0.6	1.1	-0.2	0.2	-0.9	0.9	-0.9	1.1
Sum of active levers in priming session hrs 5-6	1.9	1.9	3.9	2.0	-2.0	-0.6	1.0	-1.0	0.9
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.5	0.4	-0.4	0.5	-0.3	0.3	-0.7
Time to tail flick, vehicle, after self-admin	0.6	0.7	1.2	-0.5	0.5	-1.1	0.8	-0.8	1.1
Time to tail flick, test, before self-admin	1.4	1.4	3.4	-1.9	1.9	-0.9	0.2	-0.3	0.8
Time to tail flick, test, after self-admin	2.1	2.1	3.5	0.1	-0.1	1.7	-1.9	1.9	-1.7
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.4	0.4	-0.2	-0.0	-0.0	0.4
Delta time to tail flick, test, before/after SA	2.4	2.1	2.8	1.4	-1.4	1.7	-1.2	1.3	-1.6
Ambulatory time before self-admin	1.0	1.0	1.7	0.6	-0.6	-1.1	1.3	-1.3	1.0
Ambulatory time after self-admin	4.6	5.1	13.6	3.7	-3.7	1.4	-0.5	0.6	-1.0
Total heroin consumption	1.0	1.1	1.3	1.1	-1.1	-1.0	1.1	-1.1	1.1
Area under the delay curve	0.8	0.9	2.0	-1.4	1.4	0.4	-0.8	0.7	-0.3
Delay disc. indifference point, 0s delay	1.2	1.3	2.2	-0.4	0.4	1.4	-1.5	1.4	-1.2
Delay disc. indifference point, 16s delay	0.1	0.1	0.3	-0.6	0.6	-0.1	0.1	-0.1	0.2
Delay disc. indifference point, 2s delay	1.2	1.4	2.1	-0.4	0.4	1.3	-1.4	1.4	-1.5
Delay disc. indifference point, 24s delay	0.2	0.1	0.2	0.0	-0.0	0.4	-0.5	0.5	-0.5
Delay disc. indifference point, 4s delay	2.6	2.7	3.3	-1.8	1.8	1.3	-1.8	1.8	-1.2
Delay disc. indifference point, 8s delay	0.5	0.6	1.5	-1.2	1.2	-0.1	-0.3	0.3	0.0
Delay discount exponential model param	0.8	0.8	2.0	1.4	-1.4	-0.3	0.7	-0.7	0.3
Delay discount hyperbolic model param	1.0	1.1	2.2	1.5	-1.5	-0.5	0.9	-0.9	0.5
Fecal boli incidents, locomotor time 1	1.3	1.4	2.3	0.5	-0.5	-1.3	1.5	-1.5	1.3
Change in fecal boli incidents, locomotor task	1.1	1.1	3.1	-1.8	1.8	-0.4	-0.1	0.0	0.2
Time >=10cm from walls, locomotor time 1	1.8	1.8	2.6	-1.2	1.2	-1.6	1.2	-1.2	1.6
Bouts of movement, locomotor time 1	1.7	1.8	2.9	-1.7	1.7	-1.4	0.8	-0.8	1.4
Total resting periods, locomotor time 1	1.6	1.8	3.8	-1.9	1.9	-1.2	0.5	-0.5	1.2
Rest time, locomotor task time 1	1.5	1.7	2.1	-1.4	1.4	-1.4	1.0	-1.0	1.4
Distance moved, locomotor task time 1	0.9	1.0	1.3	1.2	-1.2	1.0	-0.8	0.8	-0.9
Vertical activity count, locomotor time 1	1.4	1.4	2.2	1.5	-1.5	1.2	-0.8	0.8	-1.2
Time >=10cm from walls, locomotor time 2	0.7	0.8	1.1	-1.1	1.1	-1.0	0.5	-0.6	0.9
Bouts of movement, locomotor time 2	0.4	0.4	0.6	0.5	-0.5	0.7	-0.7	0.7	-0.7
Total resting periods, locomotor time 2	0.2	0.2	0.4	0.7	-0.7	0.2	-0.1	0.2	-0.3
Rest time, locomotor task time 2	2.0	2.3	4.0	-2.0	2.0	-1.5	0.9	-0.9	1.3
Distance moved, locomotor task time 2	0.8	0.9	1.2	0.7	-0.7	1.1	-1.1	1.1	-1.0
Vertical activity count, locomotor time 2	2.9	3.2	4.9	1.0	-1.0	2.2	-2.0	2.0	-2.1
Weight adjusted by age	0.7	0.8	2.0	1.4	-1.4	-0.2	0.6	-0.5	0.1
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	0.8	-0.4	0.4	-0.7	0.8	-0.8	0.9
Locomotion in novel chamber	1.8	2.2	3.0	1.7	-1.7	1.6	-0.9	1.0	-1.7
Locomotion in novel chamber post-restriction	0.5	0.6	1.7	1.3	-1.3	0.3	-0.0	0.0	-0.1
Progressive ratio	0.6	0.6	1.7	-1.3	1.3	0.0	-0.5	0.4	-0.1
Food seeking constrained by brief footshock	2.4	2.9	4.6	2.1	-2.1	1.7	-1.2	1.2	-1.7
Seeking ratio, punishment vs. effort	2.4	2.9	7.6	2.7	-2.7	1.1	-0.3	0.3	-0.9
Run reversals in cocaine runway, females	1.0	1.0	1.5	-1.1	1.1	0.7	-1.2	1.2	-0.5
Run reversals in cocaine runway, males	0.4	0.4	0.5	0.5	-0.5	-0.7	0.7	-0.7	0.5
Latency to leave start box in cocaine runway	1.8	2.0	3.3	-0.3	0.3	1.6	-1.8	1.8	-1.6
Latency to leave start box in cocaine runway, F	1.2	1.4	2.3	0.1	-0.1	1.3	-1.5	1.5	-1.3
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	-0.2	0.2	0.2	-0.1	0.2	-0.2
Cd content in liver	0.2	0.2	0.4	0.6	-0.6	0.4	-0.1	0.1	-0.4
Co content in liver	0.1	0.1	0.2	0.4	-0.4	0.4	-0.3	0.3	-0.3
Cu content in liver	1.3	1.6	4.4	2.1	-2.1	-0.1	0.6	-0.6	0.1
Fe content in liver	1.1	1.3	2.5	1.6	-1.6	-0.5	1.1	-1.0	0.5
K content in liver	0.4	0.4	0.7	-0.5	0.5	0.7	-0.8	0.8	-0.6
Mg content in liver	0.7	0.8	1.1	-0.7	0.7	0.9	-1.0	1.0	-0.9
Mn content in liver	2.2	2.5	3.1	-1.4	1.4	1.5	-1.8	1.8	-1.6
Na content in liver	0.2	0.2	0.4	0.0	-0.0	-0.4	0.6	-0.6	0.4
Rb content in liver	0.0	0.0	0.0	0.2	-0.2	0.2	-0.2	0.2	-0.1
Se content in liver	0.3	0.3	0.5	-0.3	0.3	0.7	-0.6	0.6	-0.6
Sr content in liver	0.2	0.2	0.5	-0.7	0.7	-0.2	-0.1	0.1	0.2
Zn content in liver	0.5	0.5	0.9	0.9	-0.9	0.7	-0.5	0.5	-0.5