Hub : Genes

Cabp5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver alternative polyA ENSRNOT00000096394 0.03 0.02 3.9e-03 0.02 0.01 0.01 0.02 3.4e-03 5.6e-02 1.3e-02 6.2e-03
2 Liver gene expression ENSRNOG00000014787 0.69 0 0.0e+00 0.34 0.37 0.39 0.39 4.5e-39 7.6e-43 2.3e-45 1.8e-45

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
BMI with tail0.51.62.7-0.81.6
BMI without tail1.73.65.0-1.52.2
Body weight1.77.38.2-2.52.9
Epididymis fat weight1.33.13.71.9-1.6
Glucose2.43.74.02.0-1.9
Heart weight0.60.91.1-1.00.9
Left kidney weight10.229.430.5-5.55.3
Right kidney weight5.515.716.3-3.94.0
Tail length1.23.54.0-2.01.7
Length with tail1.34.86.0-2.41.9
Length without tail0.51.21.6-1.20.9
Liver weight, left13.321.524.5-4.34.9
Liver weight, right3.76.16.9-2.32.6
Parametrial fat weight1.83.45.42.3-1.2
Retroperitoneal fat weight1.65.38.12.8-1.6
Intraocular pressure0.00.00.1-0.1-0.2
Extensor digitorum longus weight2.18.38.3-2.92.9
Soleus weight0.20.50.7-0.50.8
Tibialis anterior weight2.17.19.6-2.23.1
Tibia length3.59.912.5-3.52.7
Number of licking bursts2.63.03.4-1.71.8
Food consumed during 24 hour testing period1.92.33.21.2-1.8
Times rat made contact with spout0.40.50.50.6-0.7
Mean time between licks in bursts0.00.00.00.00.2
Mean num. licks in bursts3.84.65.22.0-2.3
Std. dev. time between licks in bursts1.41.71.8-1.31.2
Water consumed over 24 hours0.10.10.2-0.1-0.5
Indifference point 0 sec0.00.00.00.00.0
Indifference point AUC3.13.74.5-1.72.1
Indifference point function ln k1.21.73.10.5-1.7
Indifference point function log k1.21.73.10.5-1.7
Delay discounting total patch changes 0 sec0.00.00.0-0.00.2
Delay discounting total patch changes 12 sec1.31.72.2-1.11.5
Delay discounting total patch changes 18 sec2.63.53.7-1.81.9
Delay discounting total patch changes 24 sec1.51.92.4-1.21.6
Delay discounting total patch changes 6 sec0.50.71.2-0.51.1
Delay discounting time to switch 0 sec4.26.48.42.9-2.1
Delay discounting water rate 0 sec2.43.84.2-2.01.9
Delay discounting water rate 12 sec0.40.51.0-1.00.2
Delay discounting water rate 18 sec0.00.00.0-0.0-0.2
Delay discounting water rate 24 sec0.10.10.2-0.4-0.2
Delay discounting water rate 6 sec4.56.68.1-2.92.2
Locomotor activity1.82.93.1-1.61.8
Locomotor testing distance1.01.61.7-1.31.2
Locomotor testing rearing8.513.313.8-3.73.6
Light reinforcement 10.61.11.3-1.11.0
Light reinforcement 20.50.71.1-0.51.0
Reaction time number correct1.72.42.7-1.41.7
Reaction time mean minus median0.40.50.60.6-0.8
Reaction time mean minus median AUC0.00.00.0-0.1-0.1
Reaction time num false alarms6.38.79.8-2.83.1
Reaction time num false alarms AUC5.17.18.0-2.52.8
Reaction time trials correct on left1.72.42.7-1.41.7
Reaction time trials on left1.82.52.9-1.51.7
Reaction time mean1.11.51.91.0-1.4
Reaction time mean AUC1.21.51.71.2-1.3
Median of all reaction times1.01.31.71.0-1.3
Reaction time omissions0.50.70.7-0.80.8
Reaction time false alarm rate1.01.51.7-1.11.3
Reaction time premature initiation rate2.83.73.91.9-2.0
Reaction time premature initiations0.81.11.21.1-1.1
Std. dev. reaction times0.50.60.80.7-0.9
Reaction time trials completed1.82.52.9-1.51.7
Reaction time trials AUC2.33.33.7-1.71.9
Social response proportion0.80.91.1-0.81.1
Social responses2.73.53.7-1.91.8
Social time0.30.40.9-0.90.1
Conditioned locomotion0.20.20.2-0.40.4
Cocaine response after cond. corrected0.20.20.40.7-0.1
Cocaine response after cond. not corrected0.50.50.7-0.70.8
Cocaine response before conditioning5.76.99.1-3.02.2
Saline control response2.02.73.5-1.91.4
Condit. Reinf. active minus inactive responses0.60.71.4-1.20.3
Condit. Reinf. active-inactive response ratio0.60.61.1-1.00.3
Condit. Reinf. active responses0.50.71.4-1.20.2
Condit. Reinf. inactive responses0.00.00.1-0.0-0.3
Condit. Reinf. lever presses1.21.72.0-1.41.2
Condit. Reinf. lever reinforcers received0.91.22.3-1.50.5
Pavlov. Cond. lever latency0.20.30.30.5-0.5
Pavlov. Cond. magazine entry latency0.00.00.00.10.1
Pavlov. Cond. change in total contacts0.10.10.1-0.2-0.4
Pavlov. Cond. index score0.20.20.3-0.60.4
Pavlov. Cond. latency score0.00.00.0-0.10.1
Pavlov. Cond. lever contacts0.81.11.3-1.10.9
Pavlov. Cond. magazine entry number0.20.20.2-0.40.5
Pavlov. Cond. intertrial magazine entries0.70.91.5-1.20.5
Pavlov. Cond. lever-magazine prob. diff.0.30.40.4-0.70.5
Pavlov. Cond. response bias0.60.81.1-1.10.7
Conditioned reinforcement - actives1.51.51.8-1.11.3
Conditioned reinforcement - inactives2.62.93.7-1.91.5
Conditioned locomotion0.60.71.0-0.61.0
Intermittent access intake day 1-15 change0.40.30.5-0.70.4
Intermittent access intake escalation0.20.20.3-0.60.3
Intermittent access intake escalation 20.80.81.3-1.10.5
Intermitt. access day 1 inactive lever presses0.10.10.20.10.5
Intermitt. access day 15 inactive lever presses2.52.83.4-1.51.8
Intermitt. access escalation Index0.10.10.20.40.1
Intermittent access day 1 total infusions0.50.60.9-0.51.0
Intermittent access day 15 total infusions0.10.10.3-0.10.5
Intermittent access terminal intake (last 3 days)0.10.10.1-0.10.3
Intermittent access total infusions0.20.30.5-0.20.7
Intermittent access day 1 locomotion0.40.40.40.6-0.6
Intermittent access day 15 total locomotion0.30.30.30.5-0.6
Intermittent access total locomotion0.00.00.00.2-0.2
Intermittent access standard deviation0.70.71.3-0.31.2
Cocaine induced anxiety0.50.61.20.0-1.1
Post-drug Anxiety0.00.00.10.1-0.3
Baseline Anxiety0.00.00.00.20.2
Lifetime Intake0.20.20.4-0.00.6
Incentive Sensitization - Responses0.40.40.6-0.80.5
Incentive Sensitization - Breakpoint0.40.40.6-0.70.6
Progressive ratio test 1 active lever presses0.10.20.2-0.50.3
Progressive ratio test 1 breakpoint0.10.10.1-0.20.3
Progressive ratio test 1 inactive lever presses2.42.52.7-1.51.6
Progressive ratio test 2 active lever presses0.40.40.4-0.70.7
Progressive ratio test 2 breakpoint0.30.40.4-0.60.6
Progressive ratio test 2 inactive lever presses1.92.22.7-1.61.3
Total sessions with >9 infusions1.82.02.2-1.41.5
Short access day 1 total inactive lever presses1.11.21.5-1.01.2
Short access day 10 total inactive lever presses0.91.01.11.0-1.0
Short access day 1 total infusions0.10.10.2-0.30.4
Short access day 10 total infusions0.91.01.8-0.41.4
Short access total infusions0.10.10.20.50.3
Short access day 1 locomotion0.20.20.2-0.40.4
Short access day 10 total locomotion1.71.82.01.3-1.4
Short access total locomotion0.80.81.01.0-0.8
Compulsive drug intake0.20.20.20.4-0.3
One hour access (0.3 mA shock)0.00.00.0-0.1-0.1
One hour access (shock baseline)0.91.01.3-0.91.1
Number of responses in last shaping day0.40.40.7-0.40.8
Context. condit. distance diff. score0.10.10.1-0.30.3
Locomotion velocity, session 10.70.70.90.7-1.0
Locomotion distance, session 10.30.40.7-0.90.1
Locomotion velocity, session 20.91.11.1-1.01.1
Locomotion distance, session 22.33.34.3-2.11.5
Locomotion velocity, session 30.30.40.4-0.60.5
Locomotion distance, session 30.10.10.3-0.5-0.1
Stereotopy head waving bouts, day 30.00.10.10.20.2
Stereotopy head waving duration, day 30.20.20.40.6-0.1
Locomotion velocity, session 71.51.71.91.2-1.4
Locomotion distance, session 70.10.10.20.3-0.4
Stereotopy head waving bouts, day 70.10.10.1-0.40.4
Stereotopy head waving duration, day 70.30.40.4-0.60.6
Locomotion velocity, session 80.00.00.0-0.2-0.1
Locomotion distance, session 80.60.81.1-1.00.8
Degree of sensitization distance0.20.20.30.6-0.2
Degree of sensitization stereotypy1.21.31.3-1.21.1
Condit. Reinf. active minus inactive responses0.80.81.0-0.81.0
Condit. Reinf. active-inactive response ratio0.80.81.2-0.71.1
Condit. Reinf. active responses0.70.81.0-1.00.9
Condit. Reinf. inactive responses0.10.10.2-0.5-0.2
Incentive salience index mean1.01.21.2-1.11.1
Condit. Reinf. lever presses0.71.01.2-1.10.8
Time in familiar zone, hab. session 10.20.20.5-0.70.1
Time in novel zone, hab. session 10.50.50.9-0.31.0
Total zone transitions, hab. session 10.50.81.3-1.20.4
Total locomotion distance, hab. session 10.10.10.3-0.0-0.5
Locomotion velocity, hab. session 10.50.71.20.5-1.1
Time in familiar zone, hab. session 20.10.10.1-0.4-0.0
Time in novel zone, hab. session 20.10.10.10.10.3
Total zone transitions, hab. session 21.82.33.5-1.91.1
Total locomotion distance, hab. session 20.20.30.50.3-0.7
Locomotion velocity, hab. session 20.10.10.20.1-0.5
Novel to familiar place preference ratio0.70.70.8-0.80.9
Novelty place preference0.60.60.7-0.80.8
Time in novel zone, NPP test0.60.70.7-0.80.8
Total zone transitions, NPP test0.70.91.2-1.10.8
Total locomotion distance, NPP test0.30.30.4-0.70.5
Locomotion velocity, NPP test0.30.50.6-0.80.6
Pavlov. Cond. lever latency0.91.11.11.1-1.1
Pavlov. Cond. magazine entry latency1.21.61.8-1.11.4
Pavlov. Cond. change in total contacts0.00.00.00.1-0.1
Pavlov. Cond. index score1.72.22.4-1.41.5
Pavlov. Cond. latency score0.81.01.1-1.01.1
Pavlov. Cond. lever contacts1.41.71.8-1.31.3
Pavlov. Cond. magazine entry number1.11.41.51.2-1.2
Pavlov. Cond. intertrial magazine entries0.30.30.50.5-0.7
Pavlov. Cond. lever-magazine prob. diff.2.02.52.8-1.51.7
Pavlov. Cond. response bias4.35.25.5-2.22.3
Bone: apparent density0.30.50.70.6-0.8
Bone surface0.30.61.1-1.00.4
Bone volume0.10.20.4-0.6-0.0
Bone: connectivity density0.10.20.30.4-0.5
Bone: cortical apparent density0.20.20.30.6-0.3
Bone: cortical area0.91.31.6-1.21.0
Bone: cortical porosity0.20.20.40.7-0.2
Bone: cortical porosity0.10.10.2-0.00.4
Bone: cortical thickness0.10.10.20.4-0.1
Bone: cortical thickness0.30.30.4-0.60.5
Bone: cortical tissue density0.20.20.40.6-0.3
Bone: elastic displacement3.94.44.62.2-2.0
Bone: elastic work0.30.40.50.6-0.7
Bone: endosteal estimation0.71.42.5-1.60.6
Bone: endosteal perimeter0.30.61.1-1.10.4
Bone: final force1.62.73.4-1.81.4
Bone: final moment2.03.24.2-2.01.5
Bone: marrow area0.71.62.7-1.60.7
Bone: maximum diameter3.25.86.1-2.52.3
Bone: maximum force1.12.02.7-1.71.1
Bone: maximum moment1.32.33.3-1.81.2
Bone: minimum diameter1.32.43.7-1.91.0
Bone: periosteal estimation1.12.33.4-1.91.1
Bone: periosteal perimeter0.91.42.2-1.50.8
Bone: post-yield work0.50.71.2-1.10.4
Bone: stiffness2.84.45.2-2.31.9
Bone: tissue strength0.10.10.10.2-0.2
Bone: trabecular number0.50.70.90.8-0.9
Bone: trabecular spacing0.30.40.4-0.60.6
Bone: trabecular thickness0.10.10.1-0.10.4
Bone: trabecular tissue density0.10.20.20.40.4
Breakpoint value in progressive ratio session4.55.06.12.5-2.0
Distance traveled before self-admin0.40.50.9-0.90.3
Distance traveled after self-admin0.50.61.10.2-1.1
Delta time in closed arm before/after self-admin0.10.10.1-0.40.3
Delta time in open arm before/after self-admin0.10.10.1-0.30.3
Diff in mean of infusions in LGA sessions1.51.61.71.3-1.3
Extinction: sum of active levers before priming0.60.60.70.8-0.8
Active lever presses in extinction session 60.70.71.2-0.31.1
Delta distance traveled before/after self-admin0.70.80.80.8-0.9
Delta ambulatory time before/after self-admin1.11.21.21.1-1.1
Time in closed arm before self-admin0.10.10.2-0.20.5
Time in closed arm after self-admin0.00.00.1-0.30.2
Time in open arm before self-admin0.10.10.1-0.4-0.2
Time in open arm after self-admin0.00.00.0-0.1-0.1
Sum of active levers in priming session hrs 5-62.62.62.61.6-1.6
Time to tail flick, vehicle, before self-admin0.10.10.2-0.40.1
Time to tail flick, vehicle, after self-admin0.10.10.10.1-0.3
Time to tail flick, test, before self-admin0.70.71.30.4-1.1
Time to tail flick, test, after self-admin0.00.00.0-0.20.1
Delta time to tail flick, vehicle, before/after SA0.20.20.40.6-0.1
Delta time to tail flick, test, before/after SA0.20.20.3-0.10.5
Ambulatory time before self-admin0.60.71.2-1.10.4
Ambulatory time after self-admin0.60.71.40.2-1.2
Total heroin consumption0.10.10.30.5-0.0
Area under the delay curve0.60.60.70.8-0.8
Delay disc. indifference point, 0s delay0.10.10.20.2-0.4
Delay disc. indifference point, 16s delay1.21.21.61.2-0.9
Delay disc. indifference point, 2s delay0.60.70.80.9-0.8
Delay disc. indifference point, 24s delay0.00.00.00.2-0.1
Delay disc. indifference point, 4s delay0.10.10.2-0.40.4
Delay disc. indifference point, 8s delay0.50.50.60.6-0.8
Delay discount exponential model param0.30.30.3-0.60.6
Delay discount hyperbolic model param0.10.10.1-0.40.4
Fecal boli incidents, locomotor time 10.10.20.3-0.5-0.2
Change in fecal boli incidents, locomotor task1.51.42.01.4-0.9
Time >=10cm from walls, locomotor time 10.20.20.30.3-0.5
Bouts of movement, locomotor time 10.70.81.6-0.0-1.3
Total resting periods, locomotor time 11.82.03.40.7-1.8
Rest time, locomotor task time 10.50.50.9-1.0-0.4
Distance moved, locomotor task time 10.20.20.30.10.6
Vertical activity count, locomotor time 10.30.30.50.70.2
Time >=10cm from walls, locomotor time 20.10.10.10.4-0.3
Bouts of movement, locomotor time 21.71.82.70.9-1.7
Total resting periods, locomotor time 22.02.23.31.0-1.8
Rest time, locomotor task time 21.21.32.50.4-1.6
Distance moved, locomotor task time 21.31.62.1-1.01.5
Vertical activity count, locomotor time 20.70.71.3-0.41.1
Weight adjusted by age1.31.51.7-1.31.1
Seeking ratio, delayed vs. immediate footshock1.01.11.80.7-1.3
Locomotion in novel chamber3.13.94.01.9-2.0
Locomotion in novel chamber post-restriction1.21.41.61.3-1.1
Progressive ratio0.50.60.70.7-0.8
Food seeking constrained by brief footshock1.21.42.80.3-1.7
Seeking ratio, punishment vs. effort0.10.10.1-0.3-0.3
Run reversals in cocaine runway, females1.71.71.71.3-1.3
Run reversals in cocaine runway, males2.12.12.1-1.41.4
Latency to leave start box in cocaine runway1.11.21.51.2-1.0
Latency to leave start box in cocaine runway, F0.20.20.20.4-0.4
Latency to leave start box in cocaine runway, M0.20.20.40.6-0.1
Cd content in liver0.00.00.10.0-0.3
Co content in liver1.61.81.81.4-1.4
Cu content in liver0.70.90.9-1.00.9
Fe content in liver0.50.60.7-0.70.8
K content in liver1.81.82.0-1.21.4
Mg content in liver1.41.41.8-1.01.3
Mn content in liver0.60.71.2-0.51.1
Na content in liver0.00.10.10.3-0.0
Rb content in liver0.40.50.5-0.70.7
Se content in liver3.64.46.5-1.52.6
Sr content in liver0.50.50.90.9-0.3
Zn content in liver0.30.40.6-0.30.8