Lgi1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000014758	0.03	0.02	1.5e-03	0.01	0	-0	0	6.3e-02	9.8e-02	5.1e-01	3.3e-01
2	Brain	gene expression	ENSRNOG00000014758	0.04	0.02	9.2e-04	0.01	0.01	0.01	0.01	2.3e-02	1.3e-02	4.5e-02	3.2e-02
3	Brain	mRNA stability	ENSRNOG00000014758	0.05	0.04	4.8e-03	0	0.01	0.01	0	1.0e-01	2.2e-02	1.5e-02	9.4e-02
4	Liver	gene expression	ENSRNOG00000014758	0.04	0.03	3.4e-03	0	0	0.01	0	2.3e-01	1.7e-01	2.6e-02	9.9e-02
5	PL	intron excision ratio	chr1:236043590:236044016	0.04	0.03	5.2e-03	0.03	0.01	0.01	0.01	1.8e-03	5.6e-02	4.7e-02	9.4e-02
6	PL	intron excision ratio	chr1:236043599:236044016	0.04	0.03	8.2e-03	0.03	0.01	0.01	0	3.1e-03	9.3e-02	6.8e-02	1.9e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
BMI with tail	0.5	1.8	3.1	-1.1	1.4	-0.2	-1.8	-1.4	1.4
BMI without tail	1.4	2.9	5.3	-1.6	1.4	-1.2	-2.3	-1.7	1.7
Body weight	0.3	1.4	2.5	-1.6	1.0	-0.8	-1.5	-1.0	1.0
Epididymis fat weight	0.6	1.3	3.1	-1.2	0.8	-1.0	-1.8	-1.0	1.0
Glucose	0.2	0.3	1.3	-0.7	0.2	-1.2	-0.3	0.0	-0.0
Heart weight	0.5	0.8	1.8	0.0	-1.3	-0.8	0.0	1.0	-1.0
Left kidney weight	0.3	0.8	1.4	-0.4	-0.9	-1.2	0.9	0.9	-0.9
Right kidney weight	1.0	2.9	4.5	0.4	-2.1	-0.3	1.9	2.1	-2.1
Tail length	0.3	0.9	2.8	-1.4	0.3	-1.7	-0.5	-0.4	0.4
Length with tail	0.1	0.3	0.6	-0.5	-0.4	-0.8	0.5	0.5	-0.5
Length without tail	0.2	0.5	1.3	0.3	-0.3	0.4	1.2	0.8	-0.8
Liver weight, left	0.2	0.3	1.3	-1.1	0.3	-0.6	-0.5	0.1	-0.1
Liver weight, right	0.1	0.1	0.6	-0.8	0.1	0.1	-0.3	0.3	-0.3
Parametrial fat weight	0.4	0.7	2.1	-0.7	-0.8	-1.5	0.8	0.4	-0.4
Retroperitoneal fat weight	0.1	0.2	0.8	-0.4	-0.3	-0.9	-0.5	0.1	-0.1
Intraocular pressure	0.3	0.4	1.3	1.1	-0.6	0.2	0.3	0.6	-0.6
Extensor digitorum longus weight	0.2	0.8	1.5	-1.2	1.2	-0.3	-0.4	-0.8	0.8
Soleus weight	1.2	3.4	3.7	-1.8	1.9	-1.9	-1.8	-1.8	1.8
Tibialis anterior weight	0.6	2.1	4.2	-1.5	2.1	-0.2	-1.0	-1.6	1.6
Tibia length	0.1	0.3	0.5	-0.0	-0.7	-0.5	0.6	0.5	-0.5
Number of licking bursts	1.6	1.9	3.9	1.9	-0.9	2.0	1.2	0.9	-0.9
Food consumed during 24 hour testing period	0.2	0.3	0.8	0.0	-0.6	-0.9	0.4	0.4	-0.4
Times rat made contact with spout	0.5	0.6	1.1	-0.0	0.9	0.1	-0.5	-1.1	1.1
Mean time between licks in bursts	0.2	0.2	0.9	-0.1	-0.9	-0.2	0.3	0.4	-0.4
Mean num. licks in bursts	2.7	3.3	4.4	-2.1	1.6	-1.9	-1.8	-1.7	1.7
Std. dev. time between licks in bursts	2.1	2.5	4.0	1.7	-2.0	0.6	1.3	1.7	-1.7
Water consumed over 24 hours	1.0	1.2	2.3	-0.5	1.3	-0.4	-0.7	-1.5	1.5
Indifference point 0 sec	0.5	0.8	1.5	0.6	-1.2	0.6	0.8	1.0	-1.0
Indifference point AUC	4.4	5.2	6.1	2.3	-1.8	2.1	2.5	2.5	-2.5
Indifference point function ln k	4.6	6.5	7.4	-2.5	2.3	-2.5	-2.6	-2.7	2.7
Indifference point function log k	4.6	6.5	7.4	-2.5	2.3	-2.5	-2.6	-2.7	2.7
Delay discounting total patch changes 0 sec	0.4	0.7	1.5	0.5	-1.2	0.4	0.8	0.9	-0.9
Delay discounting total patch changes 12 sec	4.1	5.5	6.0	2.4	-2.4	2.0	2.4	2.4	-2.4
Delay discounting total patch changes 18 sec	1.0	1.3	2.4	1.2	-1.0	1.6	1.0	1.0	-1.0
Delay discounting total patch changes 24 sec	0.5	0.6	0.8	0.3	-0.8	0.9	0.6	0.9	-0.9
Delay discounting total patch changes 6 sec	3.5	5.3	6.5	2.1	-2.5	1.8	2.2	2.5	-2.5
Delay discounting time to switch 0 sec	1.1	1.6	3.1	1.6	-1.0	1.7	0.9	1.1	-1.1
Delay discounting water rate 0 sec	1.5	2.3	3.7	-1.6	1.3	-1.9	-1.2	-1.5	1.5
Delay discounting water rate 12 sec	0.8	1.2	2.5	-1.3	0.7	-1.6	-0.9	-0.9	0.9
Delay discounting water rate 18 sec	1.8	2.4	3.0	-1.7	1.5	-1.4	-1.5	-1.6	1.6
Delay discounting water rate 24 sec	0.8	1.1	1.4	-0.9	1.1	-0.9	-1.2	-1.2	1.2
Delay discounting water rate 6 sec	0.2	0.3	0.9	-0.1	0.3	-0.9	-0.6	-0.4	0.4
Locomotor activity	0.2	0.3	0.8	-0.1	0.4	0.3	-0.3	-0.9	0.9
Locomotor testing distance	0.3	0.5	1.1	-0.2	0.4	0.4	-0.4	-1.1	1.1
Locomotor testing rearing	0.9	1.5	2.6	-1.0	1.4	0.3	-0.6	-1.6	1.6
Light reinforcement 1	0.2	0.4	1.0	0.7	-0.3	0.6	1.0	0.3	-0.3
Light reinforcement 2	1.1	1.4	3.1	1.4	-1.0	1.0	1.8	0.9	-0.9
Reaction time number correct	2.2	3.2	4.5	-1.6	1.9	-0.3	-1.9	-2.1	2.1
Reaction time mean minus median	0.9	1.2	5.6	-1.0	-0.3	-2.4	-0.6	-0.2	0.2
Reaction time mean minus median AUC	0.6	0.7	3.2	-0.7	-0.5	-1.8	-0.5	-0.1	0.1
Reaction time num false alarms	0.2	0.3	0.9	0.3	-0.2	1.0	0.3	0.6	-0.6
Reaction time num false alarms AUC	0.2	0.3	0.8	0.2	-0.2	0.9	0.1	0.7	-0.7
Reaction time trials correct on left	2.2	3.2	4.5	-1.6	1.9	-0.3	-1.9	-2.1	2.1
Reaction time trials on left	2.2	3.1	4.4	-1.6	1.8	-0.4	-1.9	-2.1	2.1
Reaction time mean	0.8	1.1	1.8	0.3	-1.4	-0.8	1.0	1.2	-1.2
Reaction time mean AUC	1.1	1.4	2.4	0.6	-1.6	-0.5	1.1	1.5	-1.5
Median of all reaction times	0.9	1.2	1.8	0.6	-1.3	-0.3	1.2	1.3	-1.3
Reaction time omissions	1.6	2.2	7.1	-1.9	0.1	-2.7	-1.0	-0.8	0.8
Reaction time false alarm rate	1.1	1.6	2.6	1.0	-1.1	1.0	1.1	1.6	-1.6
Reaction time premature initiation rate	0.6	0.7	1.2	0.2	-0.9	-0.6	1.0	1.1	-1.1
Reaction time premature initiations	0.2	0.3	1.0	-0.8	0.1	-1.0	-0.0	-0.1	0.1
Std. dev. reaction times	0.8	1.1	4.4	-0.7	-1.1	-2.1	-0.1	0.5	-0.5
Reaction time trials completed	2.2	3.1	4.4	-1.6	1.8	-0.4	-1.9	-2.1	2.1
Reaction time trials AUC	1.9	2.8	3.9	-1.5	1.8	-0.2	-1.8	-2.0	2.0
Social response proportion	2.7	3.0	4.6	-1.1	1.8	-1.0	-2.2	-2.0	2.0
Social responses	0.5	0.6	1.0	-0.5	0.9	-0.7	-1.0	-0.7	0.7
Social time	0.6	0.8	2.2	0.8	-0.6	1.5	0.1	1.0	-1.0
Conditioned locomotion	0.2	0.2	0.5	-0.7	0.1	-0.6	-0.4	-0.2	0.2
Cocaine response after cond. corrected	0.2	0.2	0.3	0.5	-0.4	0.1	-0.3	0.6	-0.6
Cocaine response after cond. not corrected	0.1	0.1	0.2	0.4	-0.1	0.2	-0.3	0.4	-0.4
Cocaine response before conditioning	0.1	0.1	0.1	0.2	0.2	0.4	0.4	-0.2	0.2
Saline control response	3.3	4.4	7.9	2.0	-1.4	2.7	2.8	1.6	-1.6
Condit. Reinf. active minus inactive responses	2.3	2.9	3.4	-1.7	1.8	-1.3	-1.8	-1.8	1.8
Condit. Reinf. active-inactive response ratio	1.2	1.3	1.8	-1.0	1.1	-0.8	-1.4	-1.2	1.2
Condit. Reinf. active responses	0.5	0.7	1.4	-1.0	0.7	-1.2	-0.6	-0.6	0.6
Condit. Reinf. inactive responses	0.7	0.9	1.4	0.3	-1.0	-0.4	1.2	1.2	-1.2
Condit. Reinf. lever presses	0.2	0.3	0.5	0.5	-0.6	0.3	0.7	0.7	-0.7
Condit. Reinf. lever reinforcers received	0.2	0.2	0.5	-0.7	0.4	-0.7	-0.4	-0.4	0.4
Pavlov. Cond. lever latency	1.3	1.8	2.7	-1.2	1.5	-0.6	-1.2	-1.6	1.6
Pavlov. Cond. magazine entry latency	0.1	0.1	0.4	-0.4	-0.3	-0.6	-0.2	0.1	-0.1
Pavlov. Cond. change in total contacts	0.4	0.5	0.9	0.5	-0.7	0.6	0.5	0.9	-0.9
Pavlov. Cond. index score	0.5	0.6	1.0	0.4	-0.9	0.2	0.7	1.0	-1.0
Pavlov. Cond. latency score	0.3	0.4	0.7	0.3	-0.7	-0.1	0.6	0.8	-0.8
Pavlov. Cond. lever contacts	1.1	1.5	2.2	1.0	-1.3	0.8	1.2	1.5	-1.5
Pavlov. Cond. magazine entry number	1.2	1.5	2.3	-0.7	1.5	-0.4	-1.3	-1.5	1.5
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.5	-0.8	1.2	-0.3	-0.9	-1.2	1.2
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.7	0.3	-0.7	0.2	0.5	0.9	-0.9
Pavlov. Cond. response bias	0.9	1.3	2.0	0.8	-1.3	0.6	1.0	1.4	-1.4
Conditioned reinforcement - actives	0.8	0.8	1.5	-0.9	0.9	-1.2	-0.3	-0.9	0.9
Conditioned reinforcement - inactives	2.5	2.8	4.2	-1.1	2.0	-1.7	-0.6	-2.1	2.1
Conditioned locomotion	0.4	0.5	2.5	-0.1	0.0	-1.6	0.7	-0.1	0.1
Intermittent access intake day 1-15 change	3.9	3.8	4.9	-1.5	1.8	-1.9	-2.0	-2.2	2.2
Intermittent access intake escalation	3.4	3.3	4.5	-1.5	1.5	-1.8	-2.1	-1.9	1.9
Intermittent access intake escalation 2	4.8	4.7	6.6	-1.8	2.0	-1.5	-2.6	-2.5	2.5
Intermitt. access day 1 inactive lever presses	0.3	0.3	0.8	0.4	0.5	0.1	-0.9	-0.5	0.5
Intermitt. access day 15 inactive lever presses	0.6	0.7	2.5	-0.3	0.7	-1.6	-0.2	-0.8	0.8
Intermitt. access escalation Index	1.9	1.7	2.7	-1.6	0.9	-1.1	-1.1	-1.5	1.5
Intermittent access day 1 total infusions	0.8	0.9	2.2	-0.8	0.9	-1.5	-0.3	-0.9	0.9
Intermittent access day 15 total infusions	3.7	4.2	8.8	-2.0	1.5	-3.0	-1.7	-1.9	1.9
Intermittent access terminal intake (last 3 days)	3.3	3.6	6.4	-1.7	1.6	-2.5	-1.3	-2.0	2.0
Intermittent access total infusions	2.2	2.5	5.2	-1.6	1.2	-2.3	-0.8	-1.5	1.5
Intermittent access day 1 locomotion	0.3	0.3	0.9	-0.9	0.2	-0.8	-0.4	0.0	-0.0
Intermittent access day 15 total locomotion	0.2	0.2	0.5	0.4	-0.3	-0.1	0.7	0.4	-0.4
Intermittent access total locomotion	0.1	0.1	0.3	0.1	0.1	0.1	0.6	0.1	-0.1
Intermittent access standard deviation	4.3	4.6	7.0	-2.2	1.7	-2.6	-2.1	-2.1	2.1
Cocaine induced anxiety	0.5	0.5	0.9	-0.4	0.7	0.6	-0.7	-0.9	0.9
Post-drug Anxiety	0.8	0.9	2.7	1.1	-0.7	1.6	0.6	0.6	-0.6
Baseline Anxiety	1.1	1.2	1.8	1.1	-1.1	0.6	0.7	1.3	-1.3
Lifetime Intake	1.3	1.4	4.4	-1.1	0.9	-2.1	-0.2	-1.1	1.1
Incentive Sensitization - Responses	4.3	4.3	6.3	-1.3	2.1	-2.4	-1.2	-2.5	2.5
Incentive Sensitization - Breakpoint	3.8	3.9	5.6	-1.3	1.9	-2.4	-1.0	-2.4	2.4
Progressive ratio test 1 active lever presses	0.8	0.8	1.4	-0.8	1.0	-1.2	-0.3	-1.0	1.0
Progressive ratio test 1 breakpoint	0.9	0.9	1.3	-0.9	1.1	-1.1	-0.3	-1.0	1.0
Progressive ratio test 1 inactive lever presses	3.2	3.4	4.3	-1.5	2.1	-1.8	-1.4	-2.1	2.1
Progressive ratio test 2 active lever presses	2.7	2.8	4.4	-1.2	1.7	-2.1	-0.7	-2.0	2.0
Progressive ratio test 2 breakpoint	3.3	3.7	5.6	-1.3	2.0	-2.4	-0.7	-2.3	2.3
Progressive ratio test 2 inactive lever presses	2.0	2.3	3.7	-0.9	1.7	-1.5	-0.5	-1.9	1.9
Total sessions with >9 infusions	0.2	0.2	0.6	0.3	0.0	-0.4	0.8	0.3	-0.3
Short access day 1 total inactive lever presses	2.0	2.2	3.6	-0.6	1.6	-1.5	-1.0	-1.9	1.9
Short access day 10 total inactive lever presses	0.1	0.1	0.2	0.3	0.0	0.4	-0.1	-0.5	0.5
Short access day 1 total infusions	0.6	0.6	2.3	0.5	-0.4	-0.8	1.5	0.4	-0.4
Short access day 10 total infusions	0.4	0.5	1.3	-0.1	-0.6	-1.1	0.9	0.4	-0.4
Short access total infusions	0.4	0.5	2.1	-0.0	0.3	-1.4	0.8	-0.3	0.3
Short access day 1 locomotion	0.0	0.0	0.1	-0.1	0.3	0.2	0.3	-0.1	0.1
Short access day 10 total locomotion	0.0	0.0	0.1	-0.2	-0.0	-0.0	0.0	0.2	-0.2
Short access total locomotion	0.1	0.1	0.4	0.1	-0.2	0.3	0.6	0.3	-0.3
Compulsive drug intake	4.4	4.3	7.2	-2.7	1.5	-2.5	-1.7	-2.0	2.0
One hour access (0.3 mA shock)	6.6	7.7	10.0	-2.7	2.7	-3.2	-1.7	-3.0	3.0
One hour access (shock baseline)	0.8	1.0	1.1	-1.0	1.0	-0.9	-0.8	-1.1	1.1
Number of responses in last shaping day	0.7	0.7	3.1	-0.7	0.2	-1.8	0.2	-0.5	0.5
Context. condit. distance diff. score	1.1	1.3	2.2	-1.2	1.5	-0.8	-0.7	-1.3	1.3
Locomotion velocity, session 1	1.9	2.0	3.0	1.7	-1.3	1.3	1.5	1.3	-1.3
Locomotion distance, session 1	0.9	1.2	1.8	1.3	-0.8	1.1	1.3	1.0	-1.0
Locomotion velocity, session 2	0.5	0.6	1.1	-0.4	1.0	0.5	-0.8	-0.9	0.9
Locomotion distance, session 2	0.3	0.4	2.1	0.2	0.3	1.4	-0.2	0.1	-0.1
Locomotion velocity, session 3	0.3	0.4	0.6	-0.8	0.6	-0.3	-0.3	-0.7	0.7
Locomotion distance, session 3	0.8	0.9	2.4	-1.5	0.4	-1.6	0.2	-0.5	0.5
Stereotopy head waving bouts, day 3	0.2	0.2	0.4	0.2	0.3	-0.7	0.2	-0.6	0.6
Stereotopy head waving duration, day 3	0.2	0.2	0.3	0.4	0.6	-0.4	-0.1	-0.6	0.6
Locomotion velocity, session 7	3.1	3.4	4.2	-2.1	2.0	-1.5	-1.7	-1.8	1.8
Locomotion distance, session 7	2.2	2.8	4.4	-2.1	1.7	-1.3	-1.9	-1.5	1.5
Stereotopy head waving bouts, day 7	0.4	0.5	1.8	0.5	-0.1	-0.6	1.3	-0.4	0.4
Stereotopy head waving duration, day 7	0.5	0.6	2.2	0.1	-0.1	-1.5	1.0	-0.5	0.5
Locomotion velocity, session 8	0.3	0.3	0.5	-0.6	0.7	-0.5	-0.2	-0.6	0.6
Locomotion distance, session 8	0.7	1.0	2.2	-0.7	1.5	0.9	-0.6	-1.0	1.0
Degree of sensitization distance	0.6	0.6	1.2	0.2	0.9	1.1	-1.1	-0.4	0.4
Degree of sensitization stereotypy	0.6	0.6	2.8	0.5	-0.6	-0.6	1.7	0.1	-0.1
Condit. Reinf. active minus inactive responses	0.0	0.0	0.1	-0.1	-0.3	0.2	-0.1	0.2	-0.2
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	-0.1	-0.5	-0.2	-0.0	0.3	-0.3
Condit. Reinf. active responses	0.0	0.0	0.0	-0.2	-0.1	0.1	0.2	0.2	-0.2
Condit. Reinf. inactive responses	0.1	0.1	0.2	0.2	0.1	0.3	0.5	0.2	-0.2
Incentive salience index mean	0.6	0.7	1.2	0.5	-0.8	1.1	0.5	1.0	-1.0
Condit. Reinf. lever presses	2.2	3.0	4.2	1.4	-1.6	2.1	1.4	1.9	-1.9
Time in familiar zone, hab. session 1	0.2	0.2	0.5	0.1	0.2	-0.7	-0.7	-0.4	0.4
Time in novel zone, hab. session 1	0.4	0.3	1.2	0.2	-0.3	1.1	0.6	0.5	-0.5
Total zone transitions, hab. session 1	0.1	0.2	0.7	0.2	0.2	0.8	0.3	0.0	-0.0
Total locomotion distance, hab. session 1	1.3	1.8	3.2	1.5	-0.8	1.8	1.5	1.1	-1.1
Locomotion velocity, hab. session 1	2.3	3.4	4.7	1.9	-1.3	2.1	2.2	1.7	-1.7
Time in familiar zone, hab. session 2	0.2	0.2	0.6	0.1	-0.8	-0.6	0.3	0.3	-0.3
Time in novel zone, hab. session 2	0.0	0.0	0.0	0.1	0.1	0.2	0.2	0.1	-0.1
Total zone transitions, hab. session 2	1.0	1.2	1.4	1.0	-1.0	1.2	1.1	1.2	-1.2
Total locomotion distance, hab. session 2	1.2	1.6	2.1	1.3	-1.2	0.9	1.4	1.4	-1.4
Locomotion velocity, hab. session 2	1.5	2.0	2.5	1.6	-1.1	1.4	1.5	1.4	-1.4
Novel to familiar place preference ratio	3.2	3.3	5.8	-0.9	2.4	-0.2	-1.8	-2.2	2.2
Novelty place preference	3.5	3.6	6.1	-0.9	2.5	-0.1	-2.0	-2.3	2.3
Time in novel zone, NPP test	3.5	3.7	6.1	-1.0	2.5	-0.2	-2.0	-2.3	2.3
Total zone transitions, NPP test	1.1	1.6	2.2	0.8	-1.0	1.4	1.2	1.5	-1.5
Total locomotion distance, NPP test	2.3	3.2	3.6	1.7	-1.5	1.9	1.9	1.9	-1.9
Locomotion velocity, NPP test	2.2	3.1	3.7	1.6	-1.4	1.9	1.8	1.9	-1.9
Pavlov. Cond. lever latency	0.1	0.2	0.6	0.3	-0.5	-0.8	0.3	0.1	-0.1
Pavlov. Cond. magazine entry latency	0.5	0.6	1.1	0.1	-1.1	0.3	0.5	1.1	-1.1
Pavlov. Cond. change in total contacts	0.2	0.2	0.5	-0.7	-0.4	-0.7	-0.3	0.2	-0.2
Pavlov. Cond. index score	0.2	0.3	0.5	0.1	-0.5	0.7	0.5	0.7	-0.7
Pavlov. Cond. latency score	0.2	0.3	0.6	0.1	-0.3	0.8	0.5	0.6	-0.6
Pavlov. Cond. lever contacts	0.5	0.6	1.6	0.4	-0.4	1.3	0.6	0.8	-0.8
Pavlov. Cond. magazine entry number	0.2	0.3	0.6	0.4	0.5	0.8	0.3	-0.4	0.4
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.2	0.1	-0.0	0.1	0.4	0.1	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.5	0.1	-0.6	0.7	0.5	0.7	-0.7
Pavlov. Cond. response bias	0.2	0.2	0.5	-0.2	-0.6	0.2	-0.1	0.7	-0.7
Bone: apparent density	3.6	5.9	8.0	-1.9	2.6	-2.2	-2.0	-2.8	2.8
Bone surface	3.2	5.6	7.2	-2.0	2.4	-2.1	-2.7	-2.5	2.5
Bone volume	3.2	5.3	6.2	-2.0	2.4	-2.1	-2.3	-2.5	2.5
Bone: connectivity density	5.3	8.3	10.6	-2.3	3.0	-2.4	-2.9	-3.3	3.3
Bone: cortical apparent density	0.9	1.2	2.1	1.4	-1.0	0.5	1.5	0.9	-0.9
Bone: cortical area	0.8	1.3	3.0	-1.5	0.8	-1.7	-0.9	-0.7	0.7
Bone: cortical porosity	0.6	0.7	1.5	0.0	1.2	0.2	-0.7	-1.0	1.0
Bone: cortical porosity	1.1	1.2	2.0	-0.6	1.4	-0.4	-1.2	-1.3	1.3
Bone: cortical thickness	1.1	1.9	3.0	1.1	-1.5	0.2	1.7	1.6	-1.6
Bone: cortical thickness	2.3	2.7	4.1	1.9	-1.5	1.0	2.0	1.6	-1.6
Bone: cortical tissue density	0.8	1.1	2.0	1.4	-0.9	0.6	1.3	0.8	-0.8
Bone: elastic displacement	0.1	0.1	0.3	0.5	-0.0	-0.2	-0.1	-0.5	0.5
Bone: elastic work	0.6	0.8	1.6	-0.1	0.8	-0.6	-0.7	-1.2	1.2
Bone: endosteal estimation	5.4	11.7	16.1	-3.5	3.6	-2.7	-4.0	-3.3	3.3
Bone: endosteal perimeter	5.1	10.5	14.5	-3.2	3.4	-2.3	-3.8	-3.2	3.2
Bone: final force	0.1	0.1	0.3	-0.4	0.3	-0.3	-0.6	0.1	-0.1
Bone: final moment	0.1	0.2	0.5	-0.4	0.2	-0.6	-0.7	0.1	-0.1
Bone: marrow area	5.5	11.9	16.0	-3.5	3.6	-2.7	-4.0	-3.4	3.4
Bone: maximum diameter	5.8	10.7	11.5	-3.4	3.3	-3.1	-3.1	-3.4	3.4
Bone: maximum force	0.6	1.1	1.5	-1.0	1.2	-1.2	-1.2	-0.9	0.9
Bone: maximum moment	0.7	1.2	2.2	-1.0	1.0	-1.5	-1.3	-0.8	0.8
Bone: minimum diameter	7.6	14.0	19.2	-4.4	3.4	-3.8	-3.8	-3.4	3.4
Bone: periosteal estimation	3.3	6.8	8.1	-2.8	2.7	-2.4	-2.8	-2.5	2.5
Bone: periosteal perimeter	3.6	6.0	6.8	-2.6	2.5	-2.0	-2.6	-2.4	2.4
Bone: post-yield work	1.0	1.4	2.1	-1.2	1.1	-1.4	-1.3	-0.9	0.9
Bone: stiffness	0.8	1.3	1.9	-1.4	1.4	-1.1	-0.9	-1.0	1.0
Bone: tissue strength	0.1	0.1	0.3	-0.3	0.1	-0.5	-0.5	-0.1	0.1
Bone: trabecular number	3.5	5.4	6.8	-1.9	2.2	-2.6	-2.2	-2.5	2.5
Bone: trabecular spacing	1.6	2.1	3.3	0.9	-1.8	0.4	1.6	1.7	-1.7
Bone: trabecular thickness	2.7	3.2	3.8	-1.7	1.8	-1.7	-1.6	-2.0	2.0
Bone: trabecular tissue density	0.5	0.7	1.0	-0.7	1.0	-0.6	-0.6	-1.0	1.0
Breakpoint value in progressive ratio session	0.3	0.4	0.8	0.7	-0.0	0.7	0.9	0.5	-0.5
Distance traveled before self-admin	0.9	0.9	1.6	-0.8	1.2	0.1	-0.7	-1.3	1.3
Distance traveled after self-admin	2.8	3.1	5.0	-1.0	2.2	-0.5	-1.7	-2.2	2.2
Delta time in closed arm before/after self-admin	0.5	0.5	0.9	0.3	-0.8	-0.1	0.6	1.0	-1.0
Delta time in open arm before/after self-admin	1.7	1.6	2.3	-0.9	1.5	0.5	-1.5	-1.5	1.5
Diff in mean of infusions in LGA sessions	2.0	2.2	3.1	-1.2	1.6	-1.2	-1.8	-1.6	1.6
Extinction: sum of active levers before priming	0.1	0.1	0.1	-0.2	0.4	0.3	-0.2	0.2	-0.2
Active lever presses in extinction session 6	2.7	2.6	5.7	-0.4	2.4	-0.2	-1.5	-2.0	2.0
Delta distance traveled before/after self-admin	1.4	1.5	3.0	-0.7	1.5	-0.5	-1.7	-1.3	1.3
Delta ambulatory time before/after self-admin	2.3	2.5	4.1	-1.1	1.9	-1.0	-2.0	-1.7	1.7
Time in closed arm before self-admin	1.5	1.8	2.9	-1.1	1.5	-0.8	-0.8	-1.7	1.7
Time in closed arm after self-admin	0.3	0.3	0.6	0.7	-0.0	0.7	0.8	0.2	-0.2
Time in open arm before self-admin	0.2	0.2	0.4	0.5	-0.6	0.2	-0.0	0.6	-0.6
Time in open arm after self-admin	0.3	0.3	0.7	-0.3	0.5	0.6	-0.9	-0.5	0.5
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.3	0.3	-0.0	-0.1	-0.5	-0.2	0.2
Time to tail flick, vehicle, before self-admin	0.5	0.5	1.5	0.9	-0.3	1.2	0.7	0.2	-0.2
Time to tail flick, vehicle, after self-admin	0.6	0.7	1.5	-0.5	1.2	0.7	-0.8	-0.7	0.7
Time to tail flick, test, before self-admin	2.3	2.3	4.7	-1.1	2.2	-0.3	-1.6	-1.6	1.6
Time to tail flick, test, after self-admin	1.6	1.6	2.8	-0.8	1.3	0.4	-1.7	-1.5	1.5
Delta time to tail flick, vehicle, before/after SA	1.5	1.5	2.8	-1.5	1.7	-0.4	-1.1	-1.1	1.1
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	0.1	-0.1	-0.1	0.0	-0.3	0.3
Ambulatory time before self-admin	0.6	0.6	1.1	-0.6	0.9	0.3	-0.5	-1.0	1.0
Ambulatory time after self-admin	5.0	5.5	9.0	-1.3	3.0	-0.7	-2.2	-2.9	2.9
Total heroin consumption	0.2	0.2	1.0	0.3	-0.1	-0.0	1.0	0.4	-0.4
Area under the delay curve	0.6	0.6	1.7	1.0	-0.3	1.3	0.9	0.3	-0.3
Delay disc. indifference point, 0s delay	1.3	1.5	2.9	-0.2	1.5	0.0	-0.9	-1.7	1.7
Delay disc. indifference point, 16s delay	0.7	0.7	2.5	0.8	-0.3	1.6	0.8	0.4	-0.4
Delay disc. indifference point, 2s delay	0.2	0.2	0.7	0.8	0.2	0.5	-0.0	-0.1	0.1
Delay disc. indifference point, 24s delay	1.1	1.1	2.0	0.9	-0.8	0.7	1.4	1.2	-1.2
Delay disc. indifference point, 4s delay	0.7	0.8	2.3	1.4	-0.1	1.5	0.6	0.2	-0.2
Delay disc. indifference point, 8s delay	2.2	2.3	3.2	1.4	-1.4	1.8	1.6	1.3	-1.3
Delay discount exponential model param	0.7	0.7	1.8	-1.1	0.4	-1.3	-0.9	-0.4	0.4
Delay discount hyperbolic model param	0.5	0.5	1.5	-1.0	0.3	-1.2	-0.7	-0.3	0.3
Fecal boli incidents, locomotor time 1	0.8	0.9	1.8	-0.4	1.3	-0.3	0.0	-1.3	1.3
Change in fecal boli incidents, locomotor task	1.1	1.0	1.9	0.9	-1.0	1.4	0.5	1.1	-1.1
Time >=10cm from walls, locomotor time 1	0.5	0.5	2.0	-1.4	0.3	-0.8	-0.0	0.0	-0.0
Bouts of movement, locomotor time 1	0.4	0.4	1.7	0.3	-0.0	-0.5	1.3	-0.4	0.4
Total resting periods, locomotor time 1	0.5	0.5	2.8	0.4	0.0	-0.0	1.7	-0.3	0.3
Rest time, locomotor task time 1	0.9	1.0	2.3	0.3	1.0	0.6	0.4	-1.5	1.5
Distance moved, locomotor task time 1	0.8	0.9	2.0	-0.4	-0.9	-0.2	-0.3	1.4	-1.4
Vertical activity count, locomotor time 1	0.8	0.9	1.7	-0.6	-1.1	-0.1	-0.5	1.3	-1.3
Time >=10cm from walls, locomotor time 2	0.9	0.9	3.4	-1.8	0.5	-0.6	-0.3	-0.8	0.8
Bouts of movement, locomotor time 2	2.1	2.3	4.8	2.2	-1.0	1.6	1.7	1.0	-1.0
Total resting periods, locomotor time 2	2.0	2.2	4.4	2.1	-0.9	1.7	1.8	0.9	-0.9
Rest time, locomotor task time 2	0.9	1.1	3.8	1.0	-0.2	1.9	1.3	0.3	-0.3
Distance moved, locomotor task time 2	1.2	1.4	3.4	-1.8	0.4	-1.8	-1.1	-0.4	0.4
Vertical activity count, locomotor time 2	0.8	0.9	1.7	-1.2	0.1	-1.3	-1.3	-0.5	0.5
Weight adjusted by age	0.3	0.3	1.1	1.0	0.2	0.8	-0.2	-0.3	0.3
Seeking ratio, delayed vs. immediate footshock	0.1	0.2	0.6	0.3	-0.3	0.1	0.8	0.3	-0.3
Locomotion in novel chamber	2.4	2.9	4.8	-0.9	2.2	-0.9	-1.4	-2.1	2.1
Locomotion in novel chamber post-restriction	0.4	0.4	0.8	0.9	0.3	0.7	0.7	0.5	-0.5
Progressive ratio	0.1	0.1	0.3	-0.5	-0.5	-0.0	0.2	0.3	-0.3
Food seeking constrained by brief footshock	0.1	0.1	0.4	-0.4	0.0	-0.6	0.3	0.0	-0.0
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	0.3	0.3	0.0	0.1	-0.0	0.0
Run reversals in cocaine runway, females	0.3	0.3	0.9	1.0	-0.2	0.7	0.3	0.3	-0.3
Run reversals in cocaine runway, males	3.4	3.3	4.7	1.6	-1.7	1.2	2.2	2.0	-2.0
Latency to leave start box in cocaine runway	2.3	2.5	3.0	-1.5	1.4	-1.7	-1.4	-1.7	1.7
Latency to leave start box in cocaine runway, F	3.4	3.7	4.9	-1.8	1.9	-1.6	-1.8	-2.2	2.2
Latency to leave start box in cocaine runway, M	0.2	0.2	0.6	-0.5	-0.2	-0.8	-0.4	-0.1	0.1
Cd content in liver	1.7	1.9	3.8	0.9	-1.9	-0.8	1.4	1.4	-1.4
Co content in liver	0.7	0.8	1.8	0.4	-1.3	-1.3	0.8	0.6	-0.6
Cu content in liver	4.7	5.7	9.6	3.1	-2.2	2.2	2.3	2.2	-2.2
Fe content in liver	1.9	2.2	2.6	1.5	-1.6	1.5	1.2	1.5	-1.5
K content in liver	0.6	0.6	2.7	0.6	0.3	1.7	0.4	0.0	-0.0
Mg content in liver	1.2	1.2	4.7	1.0	-0.4	2.2	0.6	0.7	-0.7
Mn content in liver	3.2	3.7	5.7	2.4	-1.3	2.4	2.0	1.6	-1.6
Na content in liver	2.1	2.2	3.7	1.8	-0.8	1.9	1.6	1.2	-1.2
Rb content in liver	0.2	0.2	0.5	-0.6	0.5	-0.7	-0.1	-0.4	0.4
Se content in liver	19.6	23.7	29.8	5.5	-4.6	5.2	4.3	4.8	-4.8
Sr content in liver	0.2	0.1	0.8	-0.1	-0.2	-0.9	0.1	-0.0	0.0
Zn content in liver	1.6	1.7	3.2	1.3	-1.3	1.8	0.8	1.3	-1.3