Hub : Genes

Plce1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000014276	0.11	0.07	8.9e-06	0.02	0.03	0.03	0.03	3.5e-03	2.4e-04	4.4e-04	1.1e-04
2	BLA	gene expression	ENSRNOG00000014276	0.12	0.07	4.6e-04	0.04	0.06	0.07	0.06	2.6e-03	2.2e-04	9.2e-05	4.2e-04
3	Brain	gene expression	ENSRNOG00000014276	0.06	0.04	1.0e-03	0.03	0.03	0.02	0.03	5.2e-04	1.8e-03	1.1e-02	1.2e-03
4	Liver	mRNA stability	ENSRNOG00000014276	0.32	0.12	2.6e-10	0.08	0.07	0.09	0.08	5.6e-09	1.2e-08	9.5e-10	4.5e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
BMI with tail	1.0	3.3	5.5	2.3	1.1	1.3	-2.1
BMI without tail	1.6	3.3	4.1	1.7	1.7	1.8	-2.0
Body weight	0.4	1.7	3.2	0.5	1.8	1.6	-0.9
Epididymis fat weight	2.0	4.7	6.6	1.0	2.2	2.6	-2.5
Glucose	0.2	0.2	0.5	-0.1	0.7	0.6	0.0
Heart weight	0.5	0.8	2.2	-1.5	0.4	0.6	-0.6
Left kidney weight	0.2	0.6	2.3	-1.5	0.4	0.3	0.0
Right kidney weight	0.8	2.2	7.6	-2.7	-0.4	-0.4	0.9
Tail length	0.6	1.7	2.7	-1.5	1.6	1.2	0.7
Length with tail	0.6	2.1	4.9	-2.2	0.7	0.1	1.7
Length without tail	1.0	2.2	5.0	-1.7	-0.4	-0.8	2.2
Liver weight, left	0.9	1.4	1.8	-1.3	1.4	1.1	0.8
Liver weight, right	0.4	0.6	0.9	-0.9	0.9	0.8	0.4
Parametrial fat weight	0.3	0.5	1.2	-1.1	0.7	0.5	-0.4
Retroperitoneal fat weight	0.8	2.6	4.2	-0.5	1.5	1.9	-2.1
Intraocular pressure	0.2	0.3	0.8	-0.1	-0.5	-0.1	-0.9
Extensor digitorum longus weight	0.2	0.8	1.7	0.3	1.3	1.1	-0.2
Soleus weight	0.8	2.4	4.0	1.2	1.9	2.0	-0.8
Tibialis anterior weight	0.3	0.9	2.0	0.8	1.4	0.8	0.6
Tibia length	0.2	0.6	1.3	-1.1	0.2	-0.2	0.9
Number of licking bursts	1.4	1.6	2.9	-0.4	-1.6	-1.7	0.8
Food consumed during 24 hour testing period	0.1	0.1	0.5	-0.7	-0.1	0.1	0.2
Times rat made contact with spout	0.1	0.2	0.6	0.8	0.1	0.0	-0.2
Mean time between licks in bursts	0.2	0.2	0.9	-0.9	0.0	0.1	-0.2
Mean num. licks in bursts	2.0	2.5	3.8	1.1	1.9	1.9	-1.1
Std. dev. time between licks in bursts	0.7	0.8	1.7	-1.3	-0.8	-0.5	-0.8
Water consumed over 24 hours	0.3	0.3	1.0	1.0	0.5	0.3	-0.1
Indifference point 0 sec	0.6	1.0	3.1	-1.7	-0.5	-0.4	0.7
Indifference point AUC	5.8	6.8	7.6	-2.5	-2.4	-2.8	2.7
Indifference point function ln k	4.8	6.8	8.6	2.3	2.8	2.9	-2.3
Indifference point function log k	4.8	6.8	8.6	2.3	2.8	2.9	-2.3
Delay discounting total patch changes 0 sec	0.5	0.8	2.8	-1.7	-0.4	-0.3	0.4
Delay discounting total patch changes 12 sec	3.5	4.6	6.2	-2.0	-2.5	-2.5	1.5
Delay discounting total patch changes 18 sec	1.3	1.7	3.0	-0.8	-1.4	-1.7	1.1
Delay discounting total patch changes 24 sec	1.4	1.8	4.1	-2.0	-0.3	-0.6	1.6
Delay discounting total patch changes 6 sec	3.9	6.0	8.2	-2.9	-2.2	-2.4	2.3
Delay discounting time to switch 0 sec	0.6	0.9	2.2	-0.1	-1.5	-1.2	-0.1
Delay discounting water rate 0 sec	0.8	1.2	2.7	0.6	1.6	1.3	0.0
Delay discounting water rate 12 sec	0.5	0.8	1.9	-0.3	1.4	1.1	0.3
Delay discounting water rate 18 sec	0.9	1.2	2.8	0.3	1.7	1.4	0.4
Delay discounting water rate 24 sec	0.6	0.8	1.7	0.2	1.3	1.2	-0.1
Delay discounting water rate 6 sec	0.1	0.2	0.3	0.2	0.5	0.6	-0.4
Locomotor activity	0.1	0.1	0.2	0.4	0.4	0.2	-0.1
Locomotor testing distance	0.1	0.1	0.2	0.5	0.3	-0.0	0.2
Locomotor testing rearing	0.3	0.5	0.8	0.7	0.7	-0.1	0.9
Light reinforcement 1	0.1	0.2	0.4	0.3	-0.7	-0.4	-0.3
Light reinforcement 2	0.9	1.2	2.6	0.7	-1.6	-1.0	-0.9
Reaction time number correct	1.5	2.2	3.5	1.9	1.3	1.5	-1.1
Reaction time mean minus median	1.0	1.3	2.4	-0.1	1.2	1.5	-1.2
Reaction time mean minus median AUC	1.2	1.6	2.8	-0.0	1.0	1.6	-1.7
Reaction time num false alarms	0.6	0.8	2.2	-1.5	0.0	-0.0	1.0
Reaction time num false alarms AUC	0.6	0.9	2.7	-1.6	0.2	0.2	0.8
Reaction time trials correct on left	1.5	2.2	3.5	1.9	1.3	1.5	-1.1
Reaction time trials on left	1.6	2.2	3.3	1.8	1.3	1.6	-1.2
Reaction time mean	0.5	0.7	2.6	-1.6	0.0	0.3	-0.1
Reaction time mean AUC	0.6	0.7	2.8	-1.7	-0.3	-0.0	-0.0
Median of all reaction times	0.5	0.7	2.6	-1.6	-0.2	-0.0	0.1
Reaction time omissions	3.3	4.4	6.8	0.2	2.3	2.6	-2.4
Reaction time false alarm rate	1.3	1.9	5.3	-2.3	-0.5	-0.6	1.3
Reaction time premature initiation rate	0.6	0.9	2.4	-1.5	-0.0	-0.1	1.0
Reaction time premature initiations	0.3	0.4	0.6	-0.5	0.7	0.8	0.2
Std. dev. reaction times	1.3	1.7	2.6	-1.2	1.1	1.6	-1.3
Reaction time trials completed	1.6	2.2	3.3	1.8	1.3	1.6	-1.2
Reaction time trials AUC	1.5	2.1	3.2	1.8	1.3	1.5	-1.2
Social response proportion	2.6	2.8	7.3	2.7	1.0	1.0	-1.4
Social responses	0.3	0.4	1.2	1.1	0.4	0.3	-0.6
Social time	0.8	1.0	1.1	-0.9	-1.0	-1.1	1.1
Conditioned locomotion	1.2	1.5	2.2	0.3	1.3	1.4	-1.5
Cocaine response after cond. corrected	0.1	0.1	0.1	-0.0	-0.4	-0.3	0.3
Cocaine response after cond. not corrected	0.2	0.3	0.4	-0.2	-0.5	-0.6	0.7
Cocaine response before conditioning	0.3	0.4	0.5	-0.5	-0.6	-0.7	0.6
Saline control response	3.9	5.2	6.4	-2.0	-2.2	-2.4	2.5
Condit. Reinf. active minus inactive responses	2.4	3.0	3.7	1.7	1.9	1.8	-1.4
Condit. Reinf. active-inactive response ratio	2.1	2.2	3.9	2.0	1.2	1.1	-1.5
Condit. Reinf. active responses	1.0	1.4	2.4	0.1	1.5	1.6	-1.1
Condit. Reinf. inactive responses	0.9	1.2	4.5	-2.1	0.0	0.2	0.3
Condit. Reinf. lever presses	0.2	0.3	0.4	-0.7	-0.5	-0.6	0.5
Condit. Reinf. lever reinforcers received	0.5	0.7	1.1	-0.1	1.0	1.1	-0.7
Pavlov. Cond. lever latency	1.1	1.5	3.3	1.8	0.9	0.9	-1.1
Pavlov. Cond. magazine entry latency	0.3	0.4	0.7	-0.9	0.6	0.5	0.3
Pavlov. Cond. change in total contacts	0.5	0.6	1.8	-1.3	-0.2	-0.3	0.8
Pavlov. Cond. index score	0.7	0.9	2.5	-1.6	-0.4	-0.4	1.0
Pavlov. Cond. latency score	0.6	0.8	2.0	-1.4	-0.2	-0.3	1.0
Pavlov. Cond. lever contacts	1.2	1.7	3.7	-1.9	-0.8	-0.9	1.2
Pavlov. Cond. magazine entry number	1.4	1.7	4.9	2.2	0.5	0.5	-1.2
Pavlov. Cond. intertrial magazine entries	0.9	1.2	2.0	1.4	0.7	0.8	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	2.3	-1.5	-0.3	-0.5	1.2
Pavlov. Cond. response bias	1.3	1.8	4.2	-2.1	-0.6	-0.8	1.4
Conditioned reinforcement - actives	0.7	0.7	2.1	0.4	-0.1	-0.7	1.5
Conditioned reinforcement - inactives	0.8	0.9	2.6	1.6	0.3	-0.3	0.8
Conditioned locomotion	0.2	0.2	0.6	-0.1	-0.1	-0.5	0.8
Intermittent access intake day 1-15 change	1.1	1.1	2.3	1.3	1.5	0.7	0.3
Intermittent access intake escalation	1.0	1.0	2.1	1.1	1.5	0.8	0.0
Intermittent access intake escalation 2	1.5	1.5	3.3	1.8	1.5	0.7	-0.0
Intermitt. access day 1 inactive lever presses	0.4	0.4	0.6	0.6	0.8	0.6	-0.6
Intermitt. access day 15 inactive lever presses	0.3	0.4	0.6	0.8	0.7	0.6	-0.2
Intermitt. access escalation Index	2.5	2.2	3.3	1.4	1.3	1.4	-1.8
Intermittent access day 1 total infusions	0.2	0.3	0.5	0.7	0.5	0.5	-0.3
Intermittent access day 15 total infusions	1.3	1.5	2.4	1.2	1.5	1.3	-0.5
Intermittent access terminal intake (last 3 days)	1.0	1.0	2.2	1.5	1.0	0.8	-0.5
Intermittent access total infusions	0.9	1.0	1.6	1.3	0.9	1.0	-0.9
Intermittent access day 1 locomotion	0.2	0.2	0.3	0.0	0.3	0.6	-0.4
Intermittent access day 15 total locomotion	1.0	1.1	1.5	-0.8	-0.8	-1.2	1.2
Intermittent access total locomotion	0.4	0.4	0.7	-0.2	-0.7	-0.8	0.7
Intermittent access standard deviation	1.7	1.8	3.7	1.4	1.9	1.2	-0.1
Cocaine induced anxiety	0.4	0.4	1.0	1.0	0.0	0.3	-0.8
Post-drug Anxiety	0.4	0.5	0.8	-0.1	-0.9	-0.5	-0.9
Baseline Anxiety	0.4	0.4	1.4	-1.2	-0.4	-0.3	0.1
Lifetime Intake	0.4	0.5	1.0	1.0	0.5	0.6	-0.6
Incentive Sensitization - Responses	1.1	1.1	2.5	1.6	0.9	0.9	-0.3
Incentive Sensitization - Breakpoint	0.9	0.9	2.0	1.4	0.9	0.8	-0.3
Progressive ratio test 1 active lever presses	0.4	0.4	1.0	1.0	0.4	0.4	-0.5
Progressive ratio test 1 breakpoint	0.4	0.4	1.1	1.0	0.4	0.4	-0.5
Progressive ratio test 1 inactive lever presses	2.0	2.2	3.2	1.8	1.8	1.3	-0.9
Progressive ratio test 2 active lever presses	0.5	0.5	1.4	1.2	0.6	0.5	0.1
Progressive ratio test 2 breakpoint	0.6	0.7	1.8	1.3	0.7	0.6	0.1
Progressive ratio test 2 inactive lever presses	0.8	0.9	3.2	1.8	0.4	0.3	-0.4
Total sessions with >9 infusions	0.5	0.6	1.0	-0.2	-0.7	-1.0	1.0
Short access day 1 total inactive lever presses	3.8	4.3	10.0	3.2	0.6	0.8	-2.5
Short access day 10 total inactive lever presses	0.3	0.3	1.0	0.5	0.3	0.2	-1.0
Short access day 1 total infusions	0.3	0.3	0.8	0.3	-0.9	-0.5	-0.5
Short access day 10 total infusions	0.2	0.2	0.3	-0.5	0.1	0.4	-0.6
Short access total infusions	0.1	0.1	0.1	0.4	-0.2	-0.2	0.1
Short access day 1 locomotion	0.2	0.2	0.3	0.6	-0.3	-0.5	-0.0
Short access day 10 total locomotion	0.2	0.2	0.6	0.2	-0.3	0.2	-0.8
Short access total locomotion	0.3	0.3	0.8	0.1	-0.6	-0.9	0.3
Compulsive drug intake	2.9	2.9	6.0	1.5	2.4	1.6	-0.9
One hour access (0.3 mA shock)	1.7	2.0	4.3	2.1	1.5	1.2	-0.2
One hour access (shock baseline)	0.1	0.1	0.3	0.5	0.1	0.4	-0.2
Number of responses in last shaping day	1.3	1.3	2.9	1.5	0.3	0.3	-1.7
Context. condit. distance diff. score	0.7	0.9	1.3	1.1	0.9	0.9	-0.7
Locomotion velocity, session 1	1.8	1.9	3.6	-0.7	-1.7	-1.9	1.0
Locomotion distance, session 1	0.5	0.7	1.0	-0.6	-0.9	-1.0	0.7
Locomotion velocity, session 2	1.3	1.5	3.7	0.5	-0.7	-1.2	1.9
Locomotion distance, session 2	0.5	0.7	2.2	-0.2	-0.4	-0.6	1.5
Locomotion velocity, session 3	0.2	0.2	0.4	0.1	0.6	0.6	0.1
Locomotion distance, session 3	0.8	0.9	1.9	-0.1	1.2	1.4	-0.5
Stereotopy head waving bouts, day 3	0.2	0.3	0.6	0.7	-0.1	0.0	-0.8
Stereotopy head waving duration, day 3	0.4	0.5	1.2	1.1	-0.2	0.0	-0.9
Locomotion velocity, session 7	2.8	3.1	4.8	1.3	2.2	2.2	-1.1
Locomotion distance, session 7	1.8	2.3	4.0	0.9	1.9	2.0	-0.9
Stereotopy head waving bouts, day 7	0.7	0.8	1.5	0.6	-1.0	-1.2	0.4
Stereotopy head waving duration, day 7	0.2	0.3	0.5	0.7	-0.4	-0.5	-0.5
Locomotion velocity, session 8	0.1	0.1	0.4	0.7	0.1	0.2	-0.2
Locomotion distance, session 8	0.2	0.4	1.2	1.1	0.0	-0.0	0.5
Degree of sensitization distance	0.2	0.2	0.4	0.3	-0.2	-0.3	0.7
Degree of sensitization stereotypy	1.1	1.3	2.5	0.0	-1.3	-1.6	0.9
Condit. Reinf. active minus inactive responses	0.1	0.2	0.4	-0.5	0.1	-0.2	0.6
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	-0.2	0.1	-0.1	-0.1
Condit. Reinf. active responses	0.2	0.3	0.7	-0.6	0.3	0.2	0.8
Condit. Reinf. inactive responses	0.2	0.2	0.6	-0.3	-0.1	0.0	0.8
Incentive salience index mean	0.8	1.0	1.8	-1.4	-0.4	-0.5	1.3
Condit. Reinf. lever presses	1.4	1.9	3.7	-1.9	-1.0	-1.0	1.4
Time in familiar zone, hab. session 1	1.2	1.2	2.9	1.0	0.5	0.7	-1.7
Time in novel zone, hab. session 1	0.8	0.8	1.7	-0.7	-0.7	-0.8	1.3
Total zone transitions, hab. session 1	0.2	0.3	1.1	0.1	-0.2	-0.4	1.1
Total locomotion distance, hab. session 1	0.9	1.3	1.9	-0.8	-1.1	-1.1	1.4
Locomotion velocity, hab. session 1	1.4	2.0	2.3	-1.3	-1.5	-1.4	1.5
Time in familiar zone, hab. session 2	0.7	0.8	2.5	-0.2	0.2	0.7	-1.6
Time in novel zone, hab. session 2	0.4	0.4	1.2	-0.0	-0.3	-0.6	1.1
Total zone transitions, hab. session 2	0.8	1.0	1.5	-1.0	-0.9	-0.9	1.2
Total locomotion distance, hab. session 2	0.5	0.6	1.5	-1.2	-0.7	-0.4	0.5
Locomotion velocity, hab. session 2	0.7	0.9	1.4	-1.2	-1.0	-0.8	0.8
Novel to familiar place preference ratio	1.3	1.4	5.0	2.2	0.2	-0.2	0.7
Novelty place preference	1.4	1.4	5.2	2.3	0.2	-0.2	0.7
Time in novel zone, NPP test	1.4	1.5	5.4	2.3	0.3	-0.1	0.6
Total zone transitions, NPP test	0.9	1.3	2.5	-1.6	-0.5	-0.6	1.5
Total locomotion distance, NPP test	1.6	2.2	2.8	-1.7	-1.4	-1.3	1.5
Locomotion velocity, NPP test	1.7	2.5	3.2	-1.8	-1.3	-1.3	1.8
Pavlov. Cond. lever latency	0.4	0.5	1.8	0.3	-0.1	0.1	-1.3
Pavlov. Cond. magazine entry latency	0.9	1.1	2.6	-1.6	-0.4	-0.4	1.3
Pavlov. Cond. change in total contacts	0.2	0.2	0.3	-0.5	0.5	0.4	0.3
Pavlov. Cond. index score	0.9	1.1	2.6	-1.2	-0.4	-0.5	1.6
Pavlov. Cond. latency score	0.9	1.2	3.0	-1.3	-0.3	-0.5	1.7
Pavlov. Cond. lever contacts	1.0	1.2	2.7	-1.3	-0.4	-0.5	1.7
Pavlov. Cond. magazine entry number	0.2	0.3	0.5	0.7	-0.5	-0.6	-0.1
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	-0.3	0.2	0.2	-0.0
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.8	1.8	-1.2	-0.4	-0.4	1.3
Pavlov. Cond. response bias	0.5	0.6	1.4	-1.2	0.1	0.1	1.0
Bone: apparent density	1.5	2.6	5.9	2.4	1.7	1.1	-0.5
Bone surface	1.4	2.4	3.7	1.9	1.9	1.5	-0.4
Bone volume	1.7	2.9	5.0	1.7	2.2	1.8	-0.6
Bone: connectivity density	2.6	4.0	9.2	3.0	1.9	1.4	-1.1
Bone: cortical apparent density	1.1	1.4	3.1	0.3	-1.8	-1.6	-0.2
Bone: cortical area	1.1	1.6	3.4	-0.8	1.8	1.6	-0.0
Bone: cortical porosity	0.5	0.5	2.1	1.4	-0.0	-0.1	0.3
Bone: cortical porosity	0.5	0.5	1.6	1.3	0.4	0.3	0.3
Bone: cortical thickness	1.0	1.6	5.1	-2.3	-0.6	-0.6	0.7
Bone: cortical thickness	1.7	2.0	2.5	-1.5	-1.6	-1.6	0.9
Bone: cortical tissue density	1.1	1.5	3.1	0.5	-1.8	-1.6	-0.3
Bone: elastic displacement	1.2	1.4	3.3	1.5	0.2	0.4	-1.8
Bone: elastic work	1.0	1.4	3.1	1.8	0.4	0.5	-1.4
Bone: endosteal estimation	2.9	6.2	12.7	1.8	3.6	3.0	-0.2
Bone: endosteal perimeter	2.3	4.8	9.5	1.8	3.1	2.5	-0.2
Bone: final force	0.5	0.7	1.6	-1.0	0.6	0.1	1.2
Bone: final moment	0.4	0.6	0.9	-0.9	0.9	0.5	0.8
Bone: marrow area	2.9	6.3	12.5	1.9	3.5	3.0	-0.3
Bone: maximum diameter	3.1	5.6	9.8	2.2	3.1	2.6	-1.1
Bone: maximum force	0.3	0.5	1.1	0.1	1.1	0.8	0.5
Bone: maximum moment	0.5	0.8	1.8	0.1	1.4	1.2	-0.0
Bone: minimum diameter	4.5	8.2	16.5	1.6	4.1	3.6	-1.0
Bone: periosteal estimation	1.9	3.8	8.7	0.8	2.9	2.4	0.0
Bone: periosteal perimeter	2.1	3.4	7.0	1.1	2.6	2.3	-0.5
Bone: post-yield work	0.4	0.5	1.1	0.2	1.0	1.0	-0.1
Bone: stiffness	0.4	0.6	1.3	-0.1	1.1	0.8	0.7
Bone: tissue strength	0.3	0.3	0.7	-0.1	0.6	0.8	-0.4
Bone: trabecular number	1.6	2.5	5.0	2.2	1.7	1.2	-0.9
Bone: trabecular spacing	0.7	1.0	3.4	-1.8	-0.5	-0.3	0.2
Bone: trabecular thickness	1.6	2.0	3.1	1.3	1.8	1.5	-0.8
Bone: trabecular tissue density	0.2	0.3	0.6	0.8	0.6	0.4	-0.2
Breakpoint value in progressive ratio session	1.4	1.5	3.2	-1.3	-0.6	-0.9	1.8
Distance traveled before self-admin	0.6	0.6	1.4	0.6	0.7	-0.5	1.2
Distance traveled after self-admin	1.2	1.3	4.8	2.2	0.7	0.0	0.0
Delta time in closed arm before/after self-admin	0.8	0.8	2.0	-1.4	0.4	0.9	-0.1
Delta time in open arm before/after self-admin	0.8	0.8	2.0	1.4	-0.3	-0.6	0.8
Diff in mean of infusions in LGA sessions	1.0	1.2	2.4	0.9	1.5	1.1	-0.5
Extinction: sum of active levers before priming	0.6	0.6	0.9	-1.0	0.5	0.3	1.0
Active lever presses in extinction session 6	0.9	0.9	2.8	1.7	0.6	0.4	0.5
Delta distance traveled before/after self-admin	1.5	1.6	3.1	1.8	0.7	0.9	-1.4
Delta ambulatory time before/after self-admin	2.2	2.4	4.2	2.0	1.2	1.4	-1.5
Time in closed arm before self-admin	0.7	0.8	2.9	1.7	0.6	0.3	-0.1
Time in closed arm after self-admin	0.4	0.4	0.9	-0.9	0.1	0.0	0.9
Time in open arm before self-admin	0.6	0.6	1.9	-0.2	0.3	0.8	-1.4
Time in open arm after self-admin	0.3	0.3	0.4	0.6	-0.5	-0.6	0.4
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.8	0.3	0.3	0.5	-0.9
Time to tail flick, vehicle, before self-admin	1.0	1.1	1.8	0.8	-1.4	-1.1	-0.7
Time to tail flick, vehicle, after self-admin	0.6	0.6	1.0	-0.6	1.0	0.5	1.0
Time to tail flick, test, before self-admin	0.7	0.7	1.7	1.3	0.9	0.4	0.5
Time to tail flick, test, after self-admin	0.9	0.9	2.0	1.4	0.9	0.5	-0.7
Delta time to tail flick, vehicle, before/after SA	1.7	1.7	3.4	-0.5	1.8	1.3	1.2
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	0.2	0.2	0.1	-0.5
Ambulatory time before self-admin	0.4	0.5	1.0	0.6	0.4	-0.6	1.0
Ambulatory time after self-admin	2.4	2.7	9.6	3.1	1.0	0.3	-0.2
Total heroin consumption	0.4	0.5	1.1	-1.1	-0.3	-0.2	0.9
Area under the delay curve	0.7	0.8	1.4	-0.4	-1.1	-1.2	0.7
Delay disc. indifference point, 0s delay	0.5	0.6	1.9	1.4	0.5	0.2	-0.3
Delay disc. indifference point, 16s delay	1.7	1.7	2.2	-0.8	-1.4	-1.4	1.5
Delay disc. indifference point, 2s delay	0.3	0.3	0.6	0.7	-0.3	-0.3	-0.7
Delay disc. indifference point, 24s delay	2.6	2.5	3.4	-1.4	-1.5	-1.6	1.9
Delay disc. indifference point, 4s delay	1.1	1.2	2.0	-0.2	-1.3	-1.4	1.0
Delay disc. indifference point, 8s delay	1.4	1.5	2.4	-1.1	-1.5	-1.4	0.5
Delay discount exponential model param	0.9	1.0	1.6	0.5	1.1	1.3	-0.9
Delay discount hyperbolic model param	0.6	0.6	1.2	0.3	1.0	1.1	-0.5
Fecal boli incidents, locomotor time 1	0.5	0.5	1.4	1.2	-0.1	0.7	-0.5
Change in fecal boli incidents, locomotor task	1.2	1.1	1.4	-1.2	-0.8	-1.1	1.1
Time >=10cm from walls, locomotor time 1	1.9	1.9	5.3	-1.5	0.4	-0.1	2.3
Bouts of movement, locomotor time 1	0.2	0.2	0.4	-0.2	-0.6	-0.4	0.2
Total resting periods, locomotor time 1	0.7	0.7	1.1	-0.3	-1.0	-1.0	0.9
Rest time, locomotor task time 1	0.6	0.7	1.2	1.1	-0.6	-0.9	0.6
Distance moved, locomotor task time 1	0.7	0.8	2.4	-1.6	0.7	0.4	0.4
Vertical activity count, locomotor time 1	0.5	0.5	1.8	-1.3	0.1	0.4	-0.1
Time >=10cm from walls, locomotor time 2	0.8	0.9	2.7	-0.4	0.6	-0.5	1.7
Bouts of movement, locomotor time 2	3.3	3.5	5.6	-1.0	-2.2	-2.4	1.5
Total resting periods, locomotor time 2	3.9	4.2	6.5	-1.1	-2.3	-2.5	1.9
Rest time, locomotor task time 2	1.8	2.1	3.0	-0.6	-1.5	-1.7	1.7
Distance moved, locomotor task time 2	1.6	1.8	4.1	0.0	2.0	1.6	-0.7
Vertical activity count, locomotor time 2	0.6	0.7	1.2	0.1	0.9	1.1	-0.9
Weight adjusted by age	0.6	0.7	1.5	1.0	-0.5	0.2	-1.2
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.5	-0.7	-0.2	-0.4	0.7
Locomotion in novel chamber	1.9	2.3	6.1	2.5	1.2	1.1	-0.8
Locomotion in novel chamber post-restriction	1.9	2.2	5.4	-0.4	-0.9	-1.6	2.3
Progressive ratio	1.1	1.2	2.0	-0.6	1.1	1.4	-1.2
Food seeking constrained by brief footshock	1.6	1.9	4.5	-1.7	0.5	-0.4	2.1
Seeking ratio, punishment vs. effort	2.1	2.6	6.8	-0.9	-0.6	-1.5	2.6
Run reversals in cocaine runway, females	0.1	0.1	0.3	-0.2	-0.5	-0.3	-0.3
Run reversals in cocaine runway, males	3.3	3.2	3.6	-1.9	-1.7	-1.9	1.7
Latency to leave start box in cocaine runway	3.9	4.2	5.5	1.6	2.4	2.2	-2.0
Latency to leave start box in cocaine runway, F	3.6	3.9	5.4	2.0	2.3	2.0	-1.5
Latency to leave start box in cocaine runway, M	1.5	1.5	2.5	0.1	1.2	1.3	-1.6
Cd content in liver	0.6	0.7	2.1	-1.4	-0.3	-0.1	-0.8
Co content in liver	0.8	0.9	3.5	-0.1	-0.0	0.5	-1.9
Cu content in liver	4.9	6.0	9.5	-1.5	-2.9	-3.1	2.0
Fe content in liver	1.0	1.2	2.2	-0.6	-1.3	-1.5	0.5
K content in liver	1.3	1.3	3.0	-0.1	-0.9	-1.2	1.7
Mg content in liver	1.8	1.9	3.6	-0.6	-1.2	-1.5	1.9
Mn content in liver	3.7	4.2	7.1	-0.4	-2.7	-2.6	1.7
Na content in liver	2.1	2.3	3.9	-0.2	-2.0	-1.9	1.3
Rb content in liver	0.2	0.3	0.7	-0.1	0.8	0.3	0.7
Se content in liver	13.8	16.7	29.8	-2.7	-5.5	-4.9	2.4
Sr content in liver	0.1	0.0	0.1	-0.2	-0.2	-0.0	-0.3
Zn content in liver	0.8	0.8	1.5	-0.8	-1.2	-1.0	0.5