| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | gene expression | ENSRNOG00000013659 | 0.250 | 0.0770 | 9.1e-13 | 0.061 | 0.088 | 0.083 | 0.095 | 2.6e-07 | 5.0e-10 | 1.6e-09 | 9.8e-11 |
| 2 | Adipose | mRNA stability | ENSRNOG00000013659 | 0.037 | 0.0260 | 2.3e-03 | 0.007 | 0.015 | 0.005 | 0.011 | 4.4e-02 | 7.9e-03 | 7.3e-02 | 1.9e-02 |
| 3 | BLA | gene expression | ENSRNOG00000013659 | 0.396 | 0.1137 | 0.0e+00 | 0.371 | 0.382 | 0.398 | 0.398 | 7.3e-21 | 1.3e-21 | 1.0e-22 | 1.0e-22 |
| 4 | Brain | gene expression | ENSRNOG00000013659 | 0.220 | 0.0710 | 0.0e+00 | 0.248 | 0.256 | 0.242 | 0.253 | 7.8e-23 | 1.1e-23 | 2.6e-22 | 2.4e-23 |
| 5 | Brain | mRNA stability | ENSRNOG00000013659 | 0.148 | 0.0728 | 7.0e-06 | 0.066 | 0.052 | 0.048 | 0.059 | 9.3e-07 | 1.5e-05 | 2.6e-05 | 3.9e-06 |
| 6 | IL | gene expression | ENSRNOG00000013659 | 0.217 | 0.1070 | 6.3e-04 | 0.098 | 0.126 | 0.091 | 0.085 | 2.5e-03 | 6.4e-04 | 3.3e-03 | 4.6e-03 |
| 7 | LHb | gene expression | ENSRNOG00000013659 | 0.304 | 0.1188 | 2.8e-05 | 0.259 | 0.145 | 0.040 | 0.216 | 7.5e-07 | 2.7e-04 | 4.1e-02 | 7.3e-06 |
| 8 | Liver | gene expression | ENSRNOG00000013659 | 0.093 | 0.0380 | 2.7e-08 | 0.091 | 0.080 | 0.085 | 0.091 | 2.7e-10 | 3.4e-09 | 9.8e-10 | 2.5e-10 |
| 9 | Liver | intron excision ratio | chr10:91499042:91517657 | 0.418 | 0.0913 | 0.0e+00 | 0.440 | 0.445 | 0.452 | 0.457 | 1.5e-53 | 2.0e-54 | 1.6e-55 | 2.8e-56 |
| 10 | Liver | intron excision ratio | chr10:91499042:91546090 | 0.213 | 0.0692 | 0.0e+00 | 0.181 | 0.172 | 0.179 | 0.181 | 1.1e-19 | 1.0e-18 | 1.8e-19 | 1.1e-19 |
| 11 | Liver | mRNA stability | ENSRNOG00000013659 | 0.157 | 0.0744 | 6.9e-05 | 0.045 | 0.040 | 0.033 | 0.040 | 9.4e-06 | 2.6e-05 | 1.2e-04 | 2.9e-05 |
| 12 | NAcc | gene expression | ENSRNOG00000013659 | 0.350 | 0.1100 | 0.0e+00 | 0.215 | 0.275 | 0.279 | 0.284 | 5.5e-16 | 1.2e-20 | 6.5e-21 | 2.3e-21 |
| 13 | OFC | gene expression | ENSRNOG00000013659 | 0.590 | 0.1296 | 3.3e-08 | 0.231 | 0.198 | 0.168 | 0.219 | 3.3e-06 | 1.9e-05 | 8.5e-05 | 6.2e-06 |
| 14 | PL | gene expression | ENSRNOG00000013659 | 0.303 | 0.0925 | 0.0e+00 | 0.347 | 0.342 | 0.360 | 0.360 | 2.5e-27 | 8.3e-27 | 1.7e-28 | 1.6e-28 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bone: endosteal perimeter | 13.3 | 27.3 | 43.5 | 1.5 | -5.4 | 6.2 | 5.6 | -0.3 | 6.2 | 5.1 | 6.0 | -6.0 | 6.0 | -0.4 | 6.6 | 5.6 | 5.7 |
| Bone: endosteal estimation | 11.5 | 24.9 | 38.5 | 0.3 | -5.7 | 6.1 | 5.2 | 0.4 | 6.2 | 4.9 | 5.1 | -5.8 | 6.0 | 0.8 | 5.9 | 5.3 | 5.5 |
| Bone: marrow area | 11.2 | 24.1 | 37.5 | 0.2 | -5.7 | 6.0 | 5.1 | 0.4 | 6.1 | 4.8 | 5.0 | -5.7 | 5.9 | 0.8 | 5.8 | 5.2 | 5.4 |
| Pavlov. Cond. intertrial magazine entries | 10.2 | 13.1 | 22.5 | -0.6 | -2.2 | 4.3 | 4.0 | 2.3 | 4.4 | 4.6 | 2.0 | -4.4 | 4.1 | 2.0 | 3.1 | 4.7 | 4.6 |
| Bone: minimum diameter | 9.3 | 17.2 | 25.8 | 1.1 | -3.6 | 4.7 | 4.7 | 0.4 | 4.7 | 4.4 | 4.5 | -4.9 | 4.8 | -0.0 | 5.1 | 4.8 | 4.9 |
| Short access day 10 total locomotion | 8.1 | 8.9 | 14.3 | -0.8 | -2.1 | 3.3 | 3.6 | 2.5 | 3.2 | 3.6 | 1.7 | -3.6 | 3.4 | 1.9 | 2.7 | 3.8 | 3.5 |
| Bone: periosteal estimation | 6.4 | 13.2 | 22.0 | 1.2 | -3.3 | 4.0 | 4.1 | -0.0 | 4.1 | 3.6 | 4.3 | -4.2 | 4.2 | -0.3 | 4.7 | 4.1 | 4.1 |
| Condit. Reinf. active responses | 5.2 | 7.2 | 12.3 | 1.0 | -2.6 | 2.5 | 3.4 | -0.4 | 2.6 | 3.1 | 3.0 | -3.1 | 3.2 | -0.3 | 3.5 | 2.9 | 2.9 |
| Intermittent access total locomotion | 5.2 | 5.8 | 10.0 | -0.0 | -1.4 | 2.7 | 3.0 | 1.3 | 2.6 | 3.0 | 1.9 | -2.9 | 2.7 | 1.1 | 2.6 | 3.2 | 2.8 |
| Delay discounting total patch changes 12 sec | 5.1 | 6.8 | 11.5 | 0.6 | -2.1 | 3.3 | 3.3 | 0.4 | 2.9 | 3.4 | 2.4 | -2.8 | 2.8 | 0.3 | 3.1 | 2.7 | 3.1 |
| Condit. Reinf. active minus inactive responses | 4.9 | 6.0 | 13.0 | 1.8 | -2.4 | 2.1 | 2.7 | -1.6 | 2.1 | 2.3 | 3.5 | -2.6 | 2.6 | -1.4 | 3.6 | 2.5 | 2.2 |
| Progressive ratio test 1 breakpoint | 4.7 | 4.9 | 9.3 | 0.8 | -1.5 | 2.2 | 3.0 | 0.1 | 2.0 | 2.7 | 2.3 | -2.6 | 2.4 | 0.1 | 2.7 | 2.9 | 2.5 |
| Bone: cortical thickness | 4.6 | 7.7 | 16.9 | 0.9 | 4.1 | -3.9 | -2.2 | -0.4 | -3.9 | -2.6 | -2.1 | 3.0 | -3.3 | -1.2 | -2.7 | -2.5 | -2.9 |
| Short access day 10 total infusions | 4.4 | 4.8 | 8.9 | -0.0 | -1.4 | 2.5 | 3.0 | 1.1 | 2.2 | 2.7 | 1.5 | -2.7 | 2.5 | 1.0 | 2.1 | 3.0 | 2.5 |
| Progressive ratio test 2 breakpoint | 4.3 | 4.8 | 7.9 | 0.5 | -1.5 | 2.4 | 2.5 | 0.3 | 2.4 | 2.7 | 2.2 | -2.6 | 2.5 | 0.3 | 2.6 | 2.8 | 2.7 |
| Condit. Reinf. lever reinforcers received | 4.2 | 5.9 | 10.3 | 1.0 | -2.3 | 2.3 | 3.1 | -0.3 | 2.4 | 2.9 | 2.8 | -2.8 | 2.9 | -0.3 | 3.2 | 2.7 | 2.6 |
| Bone: cortical porosity | 4.2 | 4.5 | 9.6 | -1.0 | -3.1 | 1.6 | 1.9 | 0.1 | 2.5 | 1.8 | 2.0 | -2.7 | 3.0 | 0.8 | 2.3 | 2.2 | 2.2 |
| Progressive ratio test 1 inactive lever presses | 4.1 | 4.4 | 9.2 | 0.9 | -1.6 | 2.0 | 3.0 | -0.4 | 1.7 | 2.4 | 2.5 | -2.4 | 2.3 | -0.1 | 2.7 | 2.5 | 2.2 |
| Bone: cortical thickness | 4.0 | 4.7 | 8.6 | -0.1 | 2.4 | -2.9 | -2.0 | -0.1 | -2.9 | -2.3 | -2.1 | 2.4 | -2.4 | -0.3 | -2.4 | -2.3 | -2.6 |
| Bone: periosteal perimeter | 3.9 | 6.4 | 15.2 | 2.0 | -2.2 | 2.2 | 2.6 | -1.4 | 2.3 | 2.0 | 3.9 | -2.6 | 2.6 | -1.7 | 3.7 | 2.5 | 2.5 |
| Intermittent access day 15 total locomotion | 3.8 | 4.0 | 6.2 | -0.1 | -1.5 | 2.5 | 2.4 | 0.7 | 2.3 | 2.4 | 1.7 | -2.4 | 2.2 | 0.9 | 2.2 | 2.5 | 2.3 |
| Progressive ratio test 2 active lever presses | 3.8 | 4.1 | 6.6 | 0.7 | -1.2 | 2.2 | 2.4 | 0.3 | 2.2 | 2.6 | 2.1 | -2.4 | 2.2 | 0.2 | 2.5 | 2.5 | 2.5 |
| Short access total locomotion | 3.8 | 3.9 | 8.3 | -0.5 | -1.1 | 1.9 | 2.9 | 1.7 | 1.7 | 2.4 | 1.0 | -2.5 | 2.2 | 1.5 | 1.8 | 2.7 | 2.2 |
| Progressive ratio test 1 active lever presses | 3.7 | 3.8 | 6.7 | 1.1 | -1.3 | 1.9 | 2.6 | -0.3 | 1.7 | 2.3 | 2.3 | -2.2 | 2.1 | -0.3 | 2.6 | 2.4 | 2.1 |
| Bone: maximum diameter | 3.6 | 6.6 | 14.5 | 2.0 | -1.9 | 2.5 | 2.7 | -1.1 | 2.6 | 2.3 | 3.8 | -2.6 | 2.6 | -1.5 | 3.7 | 2.6 | 2.6 |
| Food seeking constrained by brief footshock | 3.6 | 4.3 | 7.7 | -1.1 | -2.8 | 2.8 | 2.1 | 0.9 | 2.6 | 2.2 | 1.3 | -2.4 | 2.6 | 1.1 | 1.7 | 2.1 | 2.3 |
| Intermitt. access day 1 inactive lever presses | 3.5 | 3.8 | 6.9 | 0.4 | -2.0 | 1.7 | 2.5 | -0.3 | 1.9 | 2.1 | 2.3 | -2.3 | 2.2 | 0.1 | 2.6 | 2.2 | 2.0 |
| Bone: cortical apparent density | 3.5 | 4.6 | 8.9 | 0.2 | 3.0 | -2.6 | -1.9 | -0.0 | -2.8 | -2.0 | -2.2 | 2.4 | -2.6 | -0.4 | -2.6 | -2.0 | -2.3 |
| Bone surface | 3.4 | 6.1 | 14.0 | 2.1 | -1.9 | 2.4 | 1.9 | -1.7 | 2.7 | 1.9 | 3.7 | -2.4 | 2.4 | -1.7 | 3.7 | 2.3 | 2.4 |
| Bone: cortical tissue density | 3.4 | 4.4 | 8.1 | -0.0 | 2.8 | -2.5 | -1.9 | 0.1 | -2.7 | -1.9 | -2.2 | 2.4 | -2.5 | -0.2 | -2.6 | -2.0 | -2.2 |
| Delay discounting total patch changes 0 sec | 3.3 | 5.4 | 11.0 | 0.9 | -1.2 | 2.7 | 3.1 | 0.7 | 2.3 | 3.3 | 2.2 | -2.5 | 2.3 | 0.3 | 2.7 | 2.7 | 2.7 |
| Progressive ratio test 2 inactive lever presses | 3.3 | 3.8 | 6.7 | 0.6 | -0.9 | 2.3 | 2.5 | 0.7 | 2.0 | 2.6 | 1.7 | -2.3 | 2.1 | 0.4 | 2.2 | 2.6 | 2.4 |
| Indifference point 0 sec | 3.2 | 5.1 | 10.2 | 0.8 | -1.2 | 2.7 | 3.2 | 0.9 | 2.2 | 3.2 | 2.1 | -2.5 | 2.3 | 0.4 | 2.6 | 2.6 | 2.7 |
| Delay discounting total patch changes 24 sec | 2.9 | 3.7 | 6.7 | 1.4 | -0.8 | 1.9 | 2.6 | -0.0 | 1.7 | 2.6 | 2.2 | -2.0 | 1.9 | -0.5 | 2.6 | 2.1 | 2.2 |
| Reaction time false alarm rate | 2.9 | 4.0 | 7.1 | -0.4 | -2.5 | 2.1 | 2.5 | 0.1 | 2.2 | 2.0 | 1.7 | -2.5 | 2.7 | 0.7 | 2.3 | 2.1 | 2.1 |
| Incentive Sensitization - Responses | 2.9 | 2.9 | 4.4 | 0.4 | -1.4 | 2.0 | 1.7 | 0.1 | 2.0 | 2.1 | 1.9 | -1.9 | 1.9 | 0.1 | 2.0 | 1.9 | 2.1 |
| Condit. Reinf. active responses | 2.9 | 3.6 | 5.8 | -0.1 | -2.0 | 1.8 | 2.4 | 0.6 | 2.0 | 2.2 | 1.6 | -2.3 | 2.4 | 0.7 | 2.1 | 2.2 | 2.2 |
| Reaction time num false alarms AUC | 2.8 | 3.9 | 7.6 | 1.1 | -1.8 | 2.0 | 2.4 | -0.8 | 1.9 | 1.7 | 2.5 | -2.3 | 2.4 | -0.6 | 2.8 | 2.1 | 1.9 |
| Intermitt. access escalation Index | 2.8 | 2.5 | 6.1 | 1.3 | 0.4 | -1.4 | -1.6 | -2.5 | -1.6 | -1.9 | 0.3 | 1.7 | -1.5 | -2.0 | -0.5 | -2.0 | -1.8 |
| Incentive Sensitization - Breakpoint | 2.7 | 2.7 | 4.1 | 0.5 | -1.4 | 1.9 | 1.6 | -0.1 | 2.0 | 1.9 | 2.0 | -1.8 | 1.9 | -0.1 | 2.0 | 1.8 | 2.0 |
| Bone volume | 2.7 | 4.5 | 10.5 | 1.9 | -1.3 | 1.9 | 1.8 | -1.3 | 2.3 | 1.7 | 3.2 | -2.1 | 2.1 | -1.4 | 3.2 | 2.2 | 2.2 |
| Condit. Reinf. active-inactive response ratio | 2.6 | 2.7 | 5.5 | 0.7 | -2.0 | 1.3 | 1.5 | -1.0 | 1.7 | 1.5 | 2.1 | -1.9 | 1.9 | -0.6 | 2.3 | 1.8 | 1.5 |
| Food consumed during 24 hour testing period | 2.5 | 3.0 | 5.4 | -0.4 | -1.0 | 2.3 | 2.1 | 1.5 | 1.8 | 2.2 | 0.8 | -2.1 | 2.0 | 1.0 | 1.2 | 2.3 | 2.1 |
| Reaction time num false alarms | 2.5 | 3.4 | 6.8 | 1.0 | -1.8 | 1.8 | 2.4 | -0.8 | 1.6 | 1.6 | 2.3 | -2.1 | 2.3 | -0.6 | 2.6 | 2.0 | 1.7 |
| Short access total infusions | 2.5 | 2.7 | 6.7 | 0.0 | -1.3 | 1.6 | 2.6 | 0.6 | 1.3 | 2.0 | 1.2 | -2.1 | 2.0 | 0.7 | 1.7 | 2.3 | 1.6 |
| Rest time, locomotor task time 2 | 2.5 | 2.9 | 4.3 | 0.7 | 1.8 | -2.0 | -2.1 | -1.2 | -1.8 | -1.9 | -1.4 | 1.9 | -2.1 | -1.3 | -1.5 | -1.8 | -1.8 |
| Vertical activity count, locomotor time 2 | 2.5 | 2.8 | 5.8 | -2.0 | -1.7 | 1.5 | 1.6 | 1.8 | 1.7 | 1.6 | 0.3 | -1.9 | 2.0 | 2.4 | 0.7 | 1.6 | 1.5 |
| Delay discounting total patch changes 18 sec | 2.4 | 3.1 | 6.2 | -0.1 | -1.5 | 2.0 | 2.5 | 0.8 | 1.8 | 2.5 | 1.3 | -2.0 | 2.1 | 0.8 | 1.8 | 1.8 | 2.0 |
| Lifetime Intake | 2.4 | 2.7 | 5.3 | 0.4 | -1.0 | 1.8 | 2.3 | 0.4 | 1.5 | 2.1 | 1.4 | -2.0 | 1.8 | 0.3 | 1.8 | 2.2 | 1.8 |
| Time in novel zone, hab. session 2 | 2.4 | 2.4 | 5.8 | 0.9 | 2.4 | -1.7 | -1.9 | -0.5 | -1.5 | -1.6 | -0.9 | 1.8 | -2.0 | -0.9 | -1.2 | -1.5 | -1.5 |
| Locomotor testing rearing | 2.3 | 3.7 | 8.7 | -2.7 | -2.6 | 1.4 | 1.9 | 2.4 | 1.3 | 1.7 | -0.5 | -2.0 | 2.1 | 2.9 | 0.1 | 1.6 | 1.1 |
| Saline control response | 2.3 | 3.1 | 6.1 | -2.0 | -1.6 | 1.2 | 2.2 | 2.3 | 1.3 | 2.1 | -0.2 | -1.9 | 2.0 | 2.5 | 0.5 | 1.7 | 1.7 |
| Pavlov. Cond. magazine entry number | 2.3 | 2.8 | 5.4 | -0.7 | -0.7 | 1.9 | 1.8 | 1.7 | 2.0 | 1.9 | 0.4 | -2.0 | 1.8 | 1.6 | 1.1 | 2.3 | 2.1 |
| Intermittent access day 1 locomotion | 2.3 | 2.3 | 4.7 | 0.5 | -0.6 | 1.6 | 1.9 | 0.4 | 1.5 | 1.9 | 1.5 | -1.8 | 1.6 | 0.4 | 1.9 | 2.2 | 1.7 |
| Short access day 1 locomotion | 2.3 | 2.4 | 6.0 | 0.4 | -0.1 | 1.3 | 2.4 | 1.2 | 1.1 | 2.1 | 1.0 | -1.9 | 1.6 | 0.8 | 1.6 | 2.4 | 1.8 |
| Condit. Reinf. active minus inactive responses | 2.3 | 2.5 | 4.2 | -0.5 | -1.9 | 1.3 | 1.9 | 0.6 | 1.6 | 2.0 | 1.1 | -2.0 | 2.0 | 1.0 | 1.6 | 1.8 | 1.7 |
| Pavlov. Cond. magazine entry latency | 2.3 | 3.0 | 5.5 | 0.1 | -2.0 | 1.5 | 2.1 | 0.1 | 1.8 | 1.7 | 1.7 | -2.3 | 2.3 | 0.0 | 2.1 | 2.1 | 1.9 |
| Locomotion in novel chamber post-restriction | 2.3 | 2.7 | 7.0 | 2.2 | -0.8 | 1.8 | 1.2 | -1.4 | 1.5 | 1.1 | 2.6 | -1.2 | 1.0 | -1.8 | 2.4 | 1.3 | 1.4 |
| Time >=10cm from walls, locomotor time 1 | 2.2 | 2.2 | 3.8 | 0.9 | 0.4 | -1.5 | -1.4 | -1.9 | -1.6 | -1.9 | -0.3 | 1.7 | -1.6 | -1.6 | -0.8 | -1.9 | -1.8 |
| Intermittent access total infusions | 2.1 | 2.3 | 4.1 | 0.5 | -1.0 | 1.9 | 2.0 | 0.3 | 1.5 | 1.9 | 1.4 | -1.8 | 1.7 | 0.1 | 1.8 | 2.0 | 1.7 |
| Bone: cortical porosity | 2.1 | 2.3 | 4.3 | -0.0 | -2.0 | 1.0 | 1.5 | -0.6 | 1.5 | 1.3 | 1.9 | -1.9 | 2.1 | -0.0 | 2.0 | 1.6 | 1.4 |
| Intermitt. access day 15 inactive lever presses | 2.0 | 2.2 | 4.5 | -1.5 | -0.9 | 1.0 | 1.2 | 2.1 | 1.5 | 1.8 | -0.5 | -1.7 | 1.7 | 2.1 | 0.3 | 1.8 | 1.6 |
| Time in familiar zone, hab. session 2 | 2.0 | 2.1 | 4.7 | -0.5 | -2.2 | 1.9 | 1.8 | 0.4 | 1.6 | 1.6 | 0.9 | -1.7 | 1.8 | 0.6 | 1.2 | 1.5 | 1.4 |
| Pavlov. Cond. change in total contacts | 2.0 | 2.2 | 4.3 | -1.0 | -1.8 | 0.9 | 1.9 | 0.5 | 1.3 | 1.5 | 0.9 | -2.0 | 2.1 | 1.0 | 1.3 | 1.8 | 1.6 |
| Pavlov. Cond. index score | 2.0 | 2.6 | 4.8 | 0.1 | -1.9 | 1.2 | 2.1 | -0.2 | 1.5 | 1.3 | 1.7 | -2.1 | 2.2 | -0.1 | 2.0 | 1.9 | 1.7 |
| Delta time to tail flick, vehicle, before/after SA | 2.0 | 2.0 | 3.5 | -0.6 | -0.7 | 1.8 | 1.6 | 1.3 | 1.6 | 1.8 | 0.4 | -1.6 | 1.4 | 1.1 | 0.9 | 1.9 | 1.7 |
| K content in liver | 2.0 | 2.0 | 6.2 | 1.5 | -1.3 | 1.1 | 1.1 | -1.7 | 1.1 | 0.6 | 2.5 | -1.0 | 1.0 | -1.7 | 2.1 | 0.9 | 1.1 |
| Condit. Reinf. inactive responses | 1.9 | 2.4 | 6.2 | 0.1 | -1.0 | 1.6 | 2.5 | 1.0 | 1.3 | 2.3 | 1.0 | -1.7 | 1.8 | 0.8 | 1.5 | 1.7 | 1.8 |
| Intermittent access terminal intake (last 3 days) | 1.9 | 2.1 | 3.9 | -0.0 | -1.1 | 2.0 | 1.6 | 0.7 | 1.7 | 1.8 | 0.9 | -1.8 | 1.6 | 0.5 | 1.3 | 1.9 | 1.7 |
| Bone: elastic displacement | 1.9 | 2.1 | 4.3 | 0.1 | 1.4 | -2.1 | -1.6 | -1.1 | -1.9 | -1.5 | -0.9 | 1.7 | -1.6 | -0.5 | -1.2 | -1.7 | -1.7 |
| Bone: trabecular tissue density | 1.9 | 2.7 | 6.9 | 2.4 | 2.6 | -1.4 | -1.2 | -1.1 | -1.8 | -0.9 | 0.1 | 1.8 | -2.1 | -2.1 | -0.5 | -1.4 | -1.4 |
| Run reversals in cocaine runway, females | 1.9 | 1.9 | 6.0 | -1.7 | 1.4 | -0.9 | -1.4 | 2.0 | -0.6 | -0.5 | -2.4 | 0.7 | -0.8 | 1.9 | -1.9 | -0.4 | -0.7 |
| Delay discounting total patch changes 6 sec | 1.8 | 2.7 | 5.3 | 0.6 | -1.0 | 1.9 | 2.3 | 0.4 | 1.6 | 2.3 | 1.6 | -1.8 | 1.7 | -0.0 | 2.0 | 1.8 | 2.0 |
| Pavlov. Cond. magazine entry latency | 1.8 | 2.0 | 3.7 | 0.7 | 0.5 | -1.4 | -1.5 | -1.7 | -1.6 | -1.7 | -0.2 | 1.7 | -1.5 | -1.5 | -0.8 | -1.9 | -1.7 |
| Incentive salience index mean | 1.8 | 2.2 | 4.0 | -0.4 | -1.9 | 1.1 | 1.7 | 0.3 | 1.5 | 1.6 | 1.3 | -1.9 | 2.0 | 0.6 | 1.6 | 1.6 | 1.6 |
| Pavlov. Cond. response bias | 1.8 | 2.2 | 4.4 | -0.0 | -1.7 | 0.9 | 1.7 | -0.1 | 1.4 | 1.3 | 1.6 | -2.0 | 2.1 | 0.0 | 1.9 | 1.8 | 1.6 |
| Active lever presses in extinction session 6 | 1.8 | 1.8 | 2.8 | -0.9 | -1.3 | 1.2 | 1.5 | 1.1 | 1.4 | 1.7 | 0.6 | -1.6 | 1.6 | 1.0 | 0.9 | 1.6 | 1.6 |
| Delay disc. indifference point, 2s delay | 1.8 | 2.0 | 7.8 | 2.8 | 0.5 | 0.7 | 0.4 | -1.8 | 0.6 | 0.5 | 2.1 | -0.3 | 0.2 | -2.4 | 1.9 | 0.6 | 0.8 |
| Length with tail | 1.7 | 6.1 | 12.5 | 2.0 | -1.8 | 2.8 | 2.3 | -1.2 | 2.7 | 2.3 | 3.4 | -2.5 | 2.4 | -1.5 | 3.5 | 2.5 | 2.5 |
| Conditioned locomotion | 1.7 | 2.0 | 3.4 | -0.2 | -0.7 | 1.4 | 1.6 | 0.7 | 1.6 | 1.8 | 1.1 | -1.7 | 1.6 | 1.0 | 1.6 | 1.8 | 1.7 |
| One hour access (shock baseline) | 1.7 | 1.9 | 3.4 | -0.6 | -1.2 | 1.7 | 1.9 | 1.0 | 1.5 | 1.6 | 0.7 | -1.7 | 1.5 | 1.0 | 1.1 | 1.8 | 1.6 |
| Pavlov. Cond. latency score | 1.7 | 2.2 | 4.1 | 0.1 | -1.9 | 1.1 | 2.0 | -0.3 | 1.2 | 1.2 | 1.7 | -1.9 | 2.0 | -0.1 | 1.9 | 1.7 | 1.5 |
| Pavlov. Cond. magazine entry number | 1.7 | 2.2 | 4.1 | 0.2 | 1.7 | -1.0 | -1.8 | -0.0 | -1.4 | -1.3 | -1.5 | 2.0 | -2.0 | -0.2 | -1.8 | -1.9 | -1.6 |
| Pavlov. Cond. lever-magazine prob. diff. | 1.7 | 2.1 | 4.1 | 0.1 | -1.7 | 1.0 | 1.9 | -0.2 | 1.3 | 1.2 | 1.6 | -1.9 | 2.0 | -0.1 | 1.9 | 1.7 | 1.5 |
| Bone: post-yield work | 1.7 | 2.3 | 4.0 | 0.7 | -1.5 | 2.0 | 1.6 | -0.1 | 1.8 | 1.5 | 1.9 | -1.6 | 1.7 | -0.4 | 2.0 | 1.5 | 1.6 |
| Bone: tissue strength | 1.7 | 1.6 | 3.2 | 1.8 | 1.3 | -1.0 | -1.0 | -1.5 | -1.3 | -1.1 | 0.4 | 1.4 | -1.4 | -1.8 | -0.2 | -1.3 | -1.3 |
| Seeking ratio, punishment vs. effort | 1.7 | 2.1 | 3.2 | -1.6 | -1.6 | 1.3 | 1.6 | 1.6 | 1.3 | 1.6 | 0.0 | -1.6 | 1.8 | 1.8 | 0.6 | 1.3 | 1.4 |
| Rb content in liver | 1.7 | 2.1 | 4.2 | 0.8 | 0.8 | -1.5 | -1.5 | -1.6 | -1.6 | -1.6 | -0.2 | 1.8 | -1.7 | -1.3 | -0.9 | -2.0 | -1.7 |
| Delay discounting water rate 12 sec | 1.6 | 2.4 | 3.8 | 1.6 | 2.0 | -1.8 | -1.5 | -1.0 | -1.9 | -1.4 | -0.4 | 1.7 | -1.8 | -1.7 | -1.0 | -1.5 | -1.7 |
| Locomotor testing distance | 1.6 | 2.6 | 5.9 | -1.3 | -1.8 | 1.2 | 2.4 | 1.4 | 0.9 | 1.9 | 0.4 | -2.0 | 2.1 | 1.8 | 0.9 | 1.9 | 1.2 |
| Time in novel zone, hab. session 1 | 1.6 | 1.6 | 3.4 | -0.1 | 1.2 | -1.8 | -1.3 | -0.2 | -1.7 | -1.6 | -1.2 | 1.3 | -1.4 | -0.3 | -1.4 | -1.2 | -1.5 |
| Cd content in liver | 1.6 | 1.8 | 3.0 | -0.8 | 0.7 | -1.2 | -1.7 | -0.0 | -1.3 | -1.2 | -1.6 | 1.7 | -1.7 | 0.3 | -1.7 | -1.7 | -1.4 |
| Tail length | 1.5 | 4.6 | 7.8 | 1.0 | -1.3 | 2.7 | 2.4 | 0.6 | 2.5 | 2.4 | 1.9 | -2.6 | 2.4 | -0.2 | 2.5 | 2.8 | 2.5 |
| Compulsive drug intake | 1.5 | 1.5 | 2.7 | 0.9 | 0.7 | -1.3 | -1.5 | -1.6 | -1.3 | -1.4 | 0.1 | 1.4 | -1.2 | -1.4 | -0.5 | -1.5 | -1.4 |
| Reaction time number correct | 1.4 | 1.9 | 5.3 | 2.3 | 1.6 | -1.0 | -1.1 | -1.6 | -1.3 | -1.3 | 0.6 | 1.3 | -1.4 | -2.2 | -0.1 | -1.0 | -1.2 |
| Reaction time trials correct on left | 1.4 | 1.9 | 5.3 | 2.3 | 1.6 | -1.0 | -1.1 | -1.6 | -1.3 | -1.3 | 0.6 | 1.3 | -1.4 | -2.2 | -0.1 | -1.0 | -1.2 |
| Reaction time trials on left | 1.4 | 2.0 | 5.4 | 2.3 | 1.7 | -1.0 | -1.2 | -1.6 | -1.3 | -1.3 | 0.6 | 1.3 | -1.4 | -2.2 | -0.1 | -1.0 | -1.2 |
| Reaction time trials completed | 1.4 | 2.0 | 5.4 | 2.3 | 1.7 | -1.0 | -1.2 | -1.6 | -1.3 | -1.3 | 0.6 | 1.3 | -1.4 | -2.2 | -0.1 | -1.0 | -1.2 |
| Reaction time trials AUC | 1.4 | 1.9 | 5.4 | 2.3 | 1.7 | -0.9 | -1.2 | -1.5 | -1.3 | -1.3 | 0.5 | 1.3 | -1.4 | -2.2 | -0.2 | -1.0 | -1.2 |
| Bone: stiffness | 1.4 | 2.2 | 6.6 | 2.6 | -0.4 | 1.3 | 1.4 | -1.3 | 0.7 | 0.6 | 2.4 | -0.8 | 0.7 | -2.1 | 2.1 | 0.8 | 0.8 |
| Delay disc. indifference point, 24s delay | 1.4 | 1.4 | 2.5 | 1.2 | 0.2 | 1.1 | 1.6 | 0.4 | 0.9 | 1.6 | 1.2 | -1.2 | 1.0 | -0.3 | 1.4 | 1.6 | 1.4 |
| Body weight | 1.3 | 5.5 | 11.1 | 1.6 | -0.7 | 2.8 | 3.3 | 0.9 | 2.0 | 3.0 | 2.1 | -2.6 | 2.3 | -0.4 | 2.6 | 3.1 | 2.7 |
| Liver weight, right | 1.3 | 2.2 | 6.5 | 2.5 | 2.0 | -1.0 | -1.0 | -1.7 | -1.3 | -1.1 | 0.8 | 1.4 | -1.5 | -2.5 | 0.1 | -1.1 | -1.0 |
| Extensor digitorum longus weight | 1.3 | 5.4 | 17.9 | -2.9 | 2.1 | -0.8 | -1.2 | 3.5 | -1.1 | -0.8 | -4.2 | 1.3 | -1.6 | 3.1 | -3.6 | -0.7 | -0.8 |
| Pavlov. Cond. intertrial magazine entries | 1.3 | 1.5 | 3.8 | 0.9 | -0.1 | 1.4 | 1.9 | 0.5 | 1.0 | 2.0 | 1.0 | -1.2 | 1.0 | 0.2 | 1.3 | 1.4 | 1.5 |
| Bone: trabecular number | 1.3 | 2.0 | 5.3 | 1.8 | -0.5 | 0.9 | 1.0 | -1.3 | 1.3 | 1.1 | 2.3 | -1.2 | 1.2 | -1.4 | 2.3 | 1.3 | 1.3 |
| Liver weight, left | 1.2 | 2.0 | 5.6 | 1.5 | -1.2 | 1.3 | 1.1 | -1.5 | 1.1 | 0.7 | 2.4 | -1.1 | 1.2 | -1.6 | 2.0 | 1.1 | 1.1 |
| Indifference point AUC | 1.2 | 1.4 | 3.1 | 0.1 | -0.9 | 1.4 | 1.8 | 0.1 | 1.1 | 1.5 | 1.0 | -1.3 | 1.4 | 0.2 | 1.4 | 1.2 | 1.5 |
| Cocaine response after cond. not corrected | 1.2 | 1.3 | 4.4 | 1.0 | 0.2 | -1.2 | -1.5 | -2.1 | -0.8 | -0.9 | 0.9 | 1.1 | -0.9 | -1.6 | 0.1 | -1.2 | -1.1 |
| Condit. Reinf. lever presses | 1.2 | 1.6 | 3.5 | -0.3 | -1.5 | 1.0 | 1.9 | 0.5 | 1.1 | 1.6 | 0.9 | -1.6 | 1.7 | 0.6 | 1.3 | 1.3 | 1.2 |
| Intermittent access standard deviation | 1.2 | 1.2 | 2.8 | -0.9 | -0.6 | 1.1 | 1.0 | 1.7 | 1.1 | 1.3 | -0.3 | -1.3 | 1.2 | 1.3 | 0.3 | 1.4 | 1.1 |
| Stereotopy head waving duration, day 7 | 1.2 | 1.4 | 3.3 | -0.0 | 0.3 | -1.8 | -1.3 | -1.4 | -1.5 | -1.4 | -0.2 | 1.3 | -1.1 | -0.8 | -0.8 | -1.5 | -1.5 |
| Time in familiar zone, hab. session 1 | 1.2 | 1.1 | 2.6 | -0.3 | -1.0 | 1.6 | 1.0 | 0.7 | 1.4 | 1.5 | 0.5 | -1.0 | 1.1 | 0.7 | 0.8 | 0.9 | 1.2 |
| Time to tail flick, vehicle, before self-admin | 1.2 | 1.2 | 4.1 | 1.7 | 0.4 | -0.6 | -1.2 | -2.0 | -0.2 | -0.7 | 1.2 | 0.7 | -0.7 | -1.9 | 0.6 | -0.8 | -0.5 |
| Na content in liver | 1.2 | 1.3 | 3.8 | 0.6 | -1.6 | 0.4 | 1.4 | -1.4 | 0.5 | 0.2 | 2.0 | -1.1 | 1.2 | -1.0 | 1.7 | 0.9 | 0.7 |
| Zn content in liver | 1.2 | 1.4 | 6.1 | 1.7 | 0.0 | -0.2 | 0.3 | -2.5 | -0.2 | 0.5 | 2.0 | -0.0 | 0.0 | -1.9 | 1.3 | 0.2 | 0.2 |
| Condit. Reinf. active-inactive response ratio | 1.1 | 1.2 | 2.8 | -0.6 | -1.7 | 0.9 | 1.2 | 0.3 | 1.1 | 1.3 | 0.7 | -1.3 | 1.4 | 0.8 | 1.0 | 1.2 | 1.1 |
| Bone: connectivity density | 1.1 | 1.7 | 4.1 | 1.4 | -0.7 | 1.0 | 0.8 | -1.0 | 1.4 | 1.0 | 1.9 | -1.2 | 1.2 | -1.2 | 2.0 | 1.2 | 1.2 |
| Bone: maximum force | 1.1 | 2.0 | 6.2 | 2.5 | 0.3 | 1.1 | 1.4 | -0.8 | 0.8 | 1.0 | 2.1 | -0.9 | 0.7 | -1.8 | 2.1 | 1.2 | 1.1 |
| Distance traveled before self-admin | 1.1 | 1.1 | 4.2 | 1.4 | -0.0 | -0.8 | -0.8 | -2.1 | -0.7 | -0.9 | 1.1 | 0.7 | -0.7 | -1.9 | 0.3 | -0.7 | -0.8 |
| Time in closed arm before self-admin | 1.1 | 1.2 | 2.5 | -0.5 | 0.6 | -1.4 | -1.0 | -0.2 | -1.5 | -1.3 | -1.4 | 1.1 | -1.0 | 0.1 | -1.3 | -1.2 | -1.6 |
| Mn content in liver | 1.1 | 1.2 | 4.4 | 2.0 | 0.1 | -0.1 | 0.1 | -2.1 | -0.1 | -0.4 | 1.8 | 0.2 | -0.2 | -1.9 | 1.3 | -0.2 | -0.2 |
| BMI without tail | 1.0 | 2.1 | 5.9 | 0.4 | 0.7 | 1.5 | 2.3 | 2.4 | 0.7 | 2.0 | -0.3 | -1.5 | 1.1 | 0.9 | 0.4 | 2.2 | 1.4 |
| Retroperitoneal fat weight | 1.0 | 3.2 | 7.1 | -0.1 | -0.9 | 2.7 | 1.8 | 1.6 | 2.2 | 2.5 | 0.8 | -1.9 | 1.8 | 1.0 | 1.4 | 2.1 | 2.2 |
| One hour access (0.3 mA shock) | 1.0 | 1.2 | 2.0 | -0.0 | -1.3 | 1.3 | 1.4 | -0.1 | 1.1 | 1.1 | 1.2 | -1.3 | 1.3 | 0.2 | 1.2 | 1.3 | 1.1 |
| Condit. Reinf. inactive responses | 1.0 | 1.2 | 2.2 | 1.2 | -0.3 | 1.2 | 1.3 | -0.2 | 1.0 | 1.1 | 1.4 | -1.1 | 1.0 | -0.7 | 1.5 | 1.3 | 1.2 |
| Pavlov. Cond. lever latency | 1.0 | 1.2 | 2.6 | -0.0 | 1.4 | -0.6 | -1.4 | 0.2 | -0.9 | -0.9 | -1.3 | 1.5 | -1.6 | 0.1 | -1.5 | -1.2 | -1.0 |
| Pavlov. Cond. lever contacts | 1.0 | 1.2 | 2.7 | -0.7 | -1.6 | 0.6 | 1.3 | 0.3 | 1.0 | 0.9 | 0.8 | -1.5 | 1.6 | 0.5 | 1.1 | 1.2 | 1.1 |
| Bone: maximum moment | 1.0 | 1.8 | 4.9 | 2.2 | 0.2 | 1.1 | 1.3 | -0.8 | 0.8 | 1.0 | 2.0 | -1.0 | 0.8 | -1.6 | 2.0 | 1.2 | 1.1 |
| Breakpoint value in progressive ratio session | 1.0 | 1.1 | 3.1 | -0.7 | -1.8 | 0.8 | 1.3 | 0.2 | 1.0 | 0.8 | 0.9 | -1.3 | 1.4 | 0.7 | 0.9 | 1.2 | 0.9 |
| Total resting periods, locomotor time 1 | 1.0 | 1.1 | 3.1 | -1.0 | 1.3 | -0.7 | -1.0 | 1.6 | -0.6 | -0.5 | -1.7 | 0.8 | -0.9 | 1.1 | -1.4 | -0.7 | -0.5 |
| Latency to leave start box in cocaine runway, F | 1.0 | 1.1 | 2.3 | 0.5 | 0.6 | -1.5 | -0.9 | -1.0 | -1.4 | -1.2 | -0.4 | 1.1 | -1.1 | -0.8 | -0.6 | -1.3 | -1.2 |
| Delay discounting water rate 0 sec | 0.9 | 1.4 | 3.9 | 0.3 | -0.1 | 1.4 | 1.6 | 0.7 | 1.1 | 2.0 | 0.7 | -1.3 | 1.0 | 0.6 | 1.1 | 1.6 | 1.5 |
| Reaction time mean minus median AUC | 0.9 | 1.2 | 2.0 | 0.4 | 1.2 | -1.2 | -1.3 | -0.2 | -1.2 | -1.4 | -0.7 | 1.3 | -1.4 | -0.5 | -0.9 | -1.3 | -1.3 |
| Intermittent access intake escalation 2 | 0.9 | 0.8 | 1.8 | -1.1 | -1.2 | 1.2 | 0.3 | 1.2 | 1.3 | 0.7 | -0.1 | -0.9 | 1.0 | 0.9 | 0.1 | 0.7 | 0.8 |
| Short access day 1 total infusions | 0.9 | 0.9 | 3.5 | 0.8 | -0.2 | 0.6 | 1.9 | -0.2 | 0.2 | 1.2 | 0.9 | -1.1 | 0.9 | -0.2 | 1.1 | 1.4 | 0.8 |
| Bone: trabecular thickness | 0.9 | 1.1 | 2.3 | 0.9 | 0.2 | 0.6 | 0.7 | -0.1 | 1.2 | 1.2 | 1.4 | -1.1 | 0.9 | -0.5 | 1.5 | 1.4 | 1.5 |
| Diff in mean of infusions in LGA sessions | 0.9 | 1.0 | 2.0 | -0.9 | 0.7 | -1.0 | -0.7 | 0.8 | -1.1 | -1.1 | -1.4 | 0.9 | -0.9 | 0.8 | -1.3 | -0.9 | -0.9 |
| Time in closed arm after self-admin | 0.9 | 0.9 | 2.3 | 0.0 | -0.2 | -0.7 | -1.2 | -1.5 | -0.8 | -1.5 | -0.1 | 1.0 | -0.7 | -0.8 | -0.6 | -1.4 | -1.3 |
| Time to tail flick, vehicle, after self-admin | 0.9 | 0.9 | 2.4 | 1.3 | 0.1 | 0.9 | 0.7 | -0.9 | 0.9 | 0.9 | 1.5 | -0.7 | 0.4 | -0.9 | 1.4 | 1.1 | 1.0 |
| Delay disc. indifference point, 4s delay | 0.9 | 1.0 | 1.6 | 1.0 | 0.9 | -1.3 | -1.1 | -1.1 | -0.9 | -1.0 | -0.0 | 1.1 | -1.0 | -1.3 | -0.2 | -1.1 | -0.9 |
| Bouts of movement, locomotor time 1 | 0.9 | 1.0 | 3.0 | -1.1 | 1.1 | -0.6 | -0.8 | 1.6 | -0.6 | -0.4 | -1.7 | 0.6 | -0.7 | 1.2 | -1.4 | -0.5 | -0.5 |
| Left kidney weight | 0.8 | 2.3 | 5.0 | 1.9 | 1.9 | -1.8 | -0.8 | -1.5 | -2.2 | -1.1 | -0.1 | 1.6 | -1.7 | -1.7 | -0.5 | -1.3 | -1.7 |
| Reaction time mean AUC | 0.8 | 1.1 | 2.2 | -0.8 | 0.3 | -1.2 | -1.4 | 0.1 | -0.9 | -1.3 | -1.2 | 1.2 | -1.1 | 0.4 | -1.2 | -1.5 | -1.2 |
| Baseline Anxiety | 0.8 | 0.9 | 1.6 | 0.3 | 1.3 | -1.1 | -1.1 | -0.5 | -1.0 | -1.0 | -0.6 | 1.1 | -1.1 | -0.5 | -0.8 | -1.1 | -0.9 |
| Degree of sensitization stereotypy | 0.8 | 0.9 | 2.1 | -0.3 | 0.1 | -1.5 | -0.8 | -0.7 | -1.3 | -1.0 | -0.5 | 1.0 | -0.8 | -0.2 | -0.8 | -1.3 | -1.3 |
| Ambulatory time before self-admin | 0.8 | 0.8 | 3.7 | 1.3 | -0.3 | -0.4 | -0.5 | -1.9 | -0.4 | -0.6 | 1.1 | 0.4 | -0.4 | -1.7 | 0.5 | -0.5 | -0.6 |
| Total resting periods, locomotor time 2 | 0.8 | 0.9 | 2.8 | -0.9 | 0.9 | -1.0 | -0.5 | 1.2 | -0.8 | -0.4 | -1.7 | 0.7 | -0.9 | 1.0 | -1.3 | -0.5 | -0.6 |
| Epididymis fat weight | 0.7 | 1.6 | 4.4 | 0.1 | 0.5 | 1.5 | 1.2 | 2.1 | 1.4 | 1.7 | -0.1 | -1.2 | 0.9 | 0.8 | 0.4 | 1.7 | 1.7 |
| Tibialis anterior weight | 0.7 | 2.6 | 7.9 | -2.4 | -0.1 | 1.0 | 1.3 | 2.8 | 0.8 | 1.3 | -1.6 | -1.1 | 0.9 | 2.8 | -0.8 | 1.4 | 1.4 |
| Tibia length | 0.7 | 2.0 | 7.6 | 2.8 | 1.2 | -0.8 | -0.3 | -2.2 | -1.0 | -0.2 | 1.5 | 0.8 | -0.9 | -2.6 | 1.0 | -0.6 | -0.6 |
| Delay discounting water rate 18 sec | 0.7 | 0.9 | 2.9 | 1.6 | 0.8 | -0.8 | -0.4 | -1.6 | -0.9 | -0.4 | 0.9 | 0.6 | -0.7 | -1.7 | 0.3 | -0.5 | -0.7 |
| Reaction time premature initiation rate | 0.7 | 0.9 | 2.0 | -0.7 | -0.2 | 0.6 | 1.2 | 1.2 | 0.6 | 1.4 | 0.0 | -1.1 | 0.9 | 1.2 | 0.4 | 1.4 | 1.1 |
| Conditioned locomotion | 0.7 | 0.9 | 1.9 | -0.5 | -0.7 | 0.9 | 1.1 | 1.1 | 1.0 | 1.4 | 0.2 | -1.0 | 1.0 | 0.9 | 0.5 | 1.1 | 1.2 |
| Cocaine response after cond. corrected | 0.7 | 0.8 | 1.8 | 1.2 | 0.8 | -0.7 | -1.1 | -1.3 | -0.5 | -0.6 | 0.7 | 0.9 | -0.9 | -1.3 | 0.1 | -0.8 | -0.7 |
| Pavlov. Cond. change in total contacts | 0.7 | 0.9 | 2.3 | 0.3 | -1.5 | 0.9 | 1.2 | -0.6 | 0.8 | 0.8 | 1.3 | -1.0 | 1.1 | -0.3 | 1.3 | 0.7 | 0.7 |
| Conditioned reinforcement - inactives | 0.7 | 0.8 | 1.5 | 0.1 | -0.5 | 1.2 | 1.2 | 0.5 | 1.0 | 1.1 | 0.7 | -1.0 | 1.0 | 0.4 | 0.9 | 1.1 | 1.0 |
| Post-drug Anxiety | 0.7 | 0.8 | 1.9 | 0.4 | 1.4 | -1.3 | -1.3 | 0.1 | -0.8 | -0.8 | -0.7 | 0.9 | -1.0 | -0.5 | -0.9 | -0.8 | -0.7 |
| Short access day 10 total inactive lever presses | 0.7 | 0.7 | 1.3 | -0.4 | -0.5 | 1.1 | 1.0 | 0.9 | 0.9 | 1.0 | 0.0 | -1.0 | 0.9 | 0.8 | 0.4 | 1.1 | 1.0 |
| Locomotion velocity, session 8 | 0.7 | 0.9 | 2.0 | -0.6 | -1.4 | 1.3 | 0.9 | -0.3 | 1.0 | 1.0 | 0.6 | -1.0 | 1.1 | 0.5 | 0.8 | 0.8 | 0.9 |
| Bone: cortical area | 0.7 | 1.1 | 2.6 | 1.4 | 0.2 | 0.5 | 1.4 | -0.2 | 0.4 | 0.9 | 1.6 | -1.0 | 0.8 | -1.0 | 1.5 | 1.2 | 1.0 |
| Bone: final force | 0.7 | 1.2 | 4.2 | 2.1 | 0.2 | 0.4 | 0.6 | -1.4 | 0.2 | 0.2 | 1.7 | -0.3 | 0.2 | -1.9 | 1.5 | 0.4 | 0.3 |
| Bone: final moment | 0.7 | 1.1 | 3.7 | 1.9 | 0.2 | 0.3 | 0.6 | -1.4 | 0.2 | 0.1 | 1.7 | -0.3 | 0.3 | -1.8 | 1.5 | 0.5 | 0.4 |
| Bouts of movement, locomotor time 2 | 0.7 | 0.7 | 2.5 | -1.0 | 0.7 | -0.7 | -0.3 | 1.5 | -0.5 | -0.1 | -1.6 | 0.4 | -0.6 | 1.2 | -1.1 | -0.2 | -0.3 |
| Se content in liver | 0.7 | 0.8 | 1.8 | 1.0 | 0.7 | -1.0 | -0.5 | -1.3 | -1.1 | -0.5 | 0.4 | 1.0 | -1.0 | -1.3 | -0.2 | -0.9 | -0.8 |
| Glucose | 0.6 | 0.9 | 1.6 | 0.2 | 0.6 | -1.1 | -1.0 | -0.7 | -1.2 | -1.1 | -0.3 | 1.1 | -1.0 | -0.7 | -0.8 | -1.2 | -1.3 |
| Right kidney weight | 0.6 | 1.7 | 4.3 | 2.1 | 1.4 | -1.2 | -0.7 | -1.7 | -1.6 | -0.9 | 0.6 | 1.1 | -1.2 | -2.0 | 0.0 | -1.0 | -1.2 |
| Intraocular pressure | 0.6 | 0.9 | 4.4 | -0.1 | 0.7 | 0.6 | 1.0 | 2.1 | 0.4 | 1.4 | -0.5 | -0.7 | 0.5 | 1.1 | -0.1 | 1.2 | 0.9 |
| Reaction time mean | 0.6 | 0.8 | 2.0 | -0.4 | 0.4 | -1.1 | -1.3 | -0.1 | -0.7 | -1.1 | -0.9 | 1.1 | -1.0 | 0.1 | -0.9 | -1.4 | -1.1 |
| Median of all reaction times | 0.6 | 0.8 | 2.1 | -0.3 | 0.3 | -1.1 | -1.2 | -0.5 | -0.8 | -1.1 | -0.7 | 1.1 | -0.9 | 0.0 | -0.8 | -1.4 | -1.1 |
| Conditioned reinforcement - actives | 0.6 | 0.6 | 1.1 | -0.1 | -0.6 | 0.8 | 1.0 | 0.5 | 0.7 | 1.0 | 0.4 | -0.9 | 0.9 | 0.5 | 0.8 | 1.0 | 0.9 |
| Intermittent access intake day 1-15 change | 0.6 | 0.6 | 1.5 | -1.1 | -1.2 | 0.9 | 0.2 | 1.1 | 1.0 | 0.5 | -0.3 | -0.7 | 0.8 | 0.7 | -0.1 | 0.5 | 0.6 |
| Intermittent access day 1 total infusions | 0.6 | 0.7 | 1.5 | 1.0 | 0.2 | 0.6 | 1.1 | -0.5 | 0.4 | 0.9 | 1.1 | -0.8 | 0.6 | -0.4 | 1.2 | 1.2 | 0.7 |
| Extinction: sum of active levers before priming | 0.6 | 0.6 | 1.3 | -0.1 | -0.6 | 0.9 | 1.2 | 0.4 | 0.6 | 0.6 | 0.5 | -1.0 | 0.9 | 0.3 | 0.6 | 1.1 | 0.8 |
| Time to tail flick, test, before self-admin | 0.6 | 0.6 | 1.5 | -1.0 | 0.1 | -0.5 | -1.2 | 0.3 | -0.2 | -0.7 | -1.2 | 0.7 | -0.6 | 0.6 | -1.1 | -1.0 | -0.6 |
| Distance moved, locomotor task time 2 | 0.6 | 0.7 | 2.3 | -1.5 | -0.9 | 0.6 | 0.4 | 1.4 | 0.7 | 0.4 | -0.2 | -0.6 | 0.8 | 1.5 | -0.0 | 0.2 | 0.5 |
| Locomotion in novel chamber | 0.6 | 0.8 | 3.0 | 1.3 | -0.2 | -0.3 | -0.5 | -1.7 | -0.1 | -0.4 | 1.2 | 0.4 | -0.3 | -1.6 | 0.8 | -0.8 | -0.3 |
| Length without tail | 0.5 | 1.2 | 4.2 | 1.0 | -0.9 | 0.8 | 0.3 | -1.6 | 1.0 | 0.5 | 2.0 | -0.6 | 0.6 | -1.3 | 1.7 | 0.4 | 0.8 |
| Parametrial fat weight | 0.5 | 0.9 | 1.9 | 1.0 | 0.2 | 1.2 | 0.1 | -0.2 | 1.3 | 0.8 | 1.0 | -1.0 | 0.8 | -0.8 | 1.1 | 1.4 | 1.2 |
| Times rat made contact with spout | 0.5 | 0.6 | 1.0 | 0.1 | -0.8 | 1.0 | 0.7 | 0.0 | 1.0 | 0.8 | 0.6 | -1.0 | 0.9 | -0.1 | 0.8 | 0.9 | 0.9 |
| Mean num. licks in bursts | 0.5 | 0.5 | 2.0 | -0.8 | 0.1 | 0.5 | 0.5 | 1.4 | 0.6 | 0.9 | -0.6 | -0.6 | 0.6 | 1.2 | -0.1 | 0.7 | 0.8 |
| Locomotor activity | 0.5 | 0.8 | 2.7 | -0.4 | -1.2 | 0.7 | 1.6 | 0.2 | 0.1 | 1.0 | 0.8 | -1.1 | 1.2 | 0.6 | 0.7 | 1.1 | 0.3 |
| Reaction time mean minus median | 0.5 | 0.6 | 1.5 | -0.9 | 0.5 | -0.5 | -0.9 | 1.2 | -0.2 | -0.6 | -1.2 | 0.6 | -0.7 | 0.8 | -0.9 | -0.6 | -0.5 |
| Locomotion velocity, session 2 | 0.5 | 0.6 | 2.5 | -0.7 | -1.6 | 0.5 | 0.7 | -0.2 | 0.7 | 0.6 | 0.6 | -0.8 | 1.1 | 0.5 | 0.7 | 0.3 | 0.4 |
| Bone: apparent density | 0.5 | 0.9 | 2.3 | 1.2 | -0.0 | 0.4 | 0.4 | -1.0 | 0.9 | 0.5 | 1.5 | -0.8 | 0.7 | -1.0 | 1.5 | 1.0 | 1.0 |
| Distance traveled after self-admin | 0.5 | 0.5 | 2.7 | 0.5 | -1.1 | -0.4 | 0.0 | -1.6 | -0.2 | -0.5 | 1.1 | 0.1 | 0.1 | -0.9 | 0.7 | -0.4 | -0.4 |
| Time in open arm before self-admin | 0.5 | 0.5 | 1.3 | 0.0 | 0.4 | -0.8 | -1.1 | -0.6 | -0.6 | -0.9 | -0.0 | 0.9 | -0.6 | -0.3 | -0.4 | -1.1 | -0.7 |
| Delta time to tail flick, test, before/after SA | 0.5 | 0.4 | 2.1 | 1.5 | 0.2 | -0.0 | 0.3 | -1.0 | -0.2 | -0.0 | 0.9 | -0.0 | -0.1 | -1.3 | 0.7 | 0.2 | -0.0 |
| Total heroin consumption | 0.5 | 0.6 | 1.8 | 0.5 | -1.1 | 0.1 | 0.7 | -1.0 | 0.4 | 0.4 | 1.4 | -0.7 | 0.8 | -0.5 | 1.2 | 0.5 | 0.5 |
| Delay disc. indifference point, 0s delay | 0.5 | 0.6 | 1.2 | 1.0 | 0.9 | -0.7 | -0.7 | -0.8 | -0.7 | -0.8 | -0.0 | 0.8 | -0.9 | -1.1 | -0.1 | -0.7 | -0.6 |
| Delay disc. indifference point, 8s delay | 0.5 | 0.5 | 2.0 | 1.3 | 1.4 | -0.7 | -0.5 | -0.5 | -0.6 | -0.3 | 0.2 | 0.6 | -0.6 | -1.0 | 0.1 | -0.4 | -0.2 |
| Delay discount exponential model param | 0.5 | 0.5 | 2.2 | -1.5 | -0.5 | -0.2 | -0.3 | 0.5 | -0.3 | -0.5 | -1.0 | 0.3 | -0.2 | 1.1 | -1.0 | -0.4 | -0.5 |
| Delay discount hyperbolic model param | 0.5 | 0.6 | 2.7 | -1.7 | -0.7 | -0.1 | -0.2 | 0.7 | -0.1 | -0.3 | -1.0 | 0.1 | -0.0 | 1.3 | -1.0 | -0.3 | -0.4 |
| Progressive ratio | 0.5 | 0.5 | 2.1 | 1.3 | 0.1 | 0.2 | -0.4 | -1.3 | 0.1 | -0.3 | 1.0 | 0.3 | -0.4 | -1.4 | 0.6 | -0.3 | -0.1 |
| Co content in liver | 0.5 | 0.5 | 3.4 | -1.8 | -1.0 | -0.2 | -0.2 | 0.3 | -0.1 | 0.2 | -0.8 | 0.1 | 0.0 | 1.3 | -0.8 | -0.4 | -0.1 |
| Indifference point function ln k | 0.4 | 0.6 | 1.2 | 0.8 | 0.9 | -1.1 | -0.8 | -0.3 | -1.1 | -0.9 | -0.0 | 0.7 | -0.9 | -0.9 | -0.5 | -0.4 | -0.9 |
| Indifference point function log k | 0.4 | 0.6 | 1.2 | 0.8 | 0.9 | -1.1 | -0.8 | -0.3 | -1.1 | -0.9 | -0.0 | 0.7 | -0.9 | -0.9 | -0.5 | -0.4 | -0.9 |
| Delay discounting water rate 24 sec | 0.4 | 0.5 | 2.1 | 1.5 | 0.3 | -0.2 | -0.4 | -1.3 | -0.4 | -0.2 | 0.8 | 0.4 | -0.5 | -1.4 | 0.3 | -0.4 | -0.4 |
| Delay discounting water rate 6 sec | 0.4 | 0.6 | 2.0 | 1.1 | 1.4 | -0.9 | -0.7 | -0.6 | -0.9 | -0.4 | -0.0 | 0.6 | -0.9 | -0.9 | -0.2 | -0.3 | -0.6 |
| Light reinforcement 2 | 0.4 | 0.5 | 1.5 | 0.1 | 0.7 | 0.2 | 1.0 | 0.6 | 0.3 | 0.8 | 0.3 | -0.8 | 0.7 | 0.5 | 0.5 | 1.2 | 0.8 |
| Std. dev. reaction times | 0.4 | 0.6 | 1.4 | -0.7 | 0.4 | -0.6 | -1.2 | 0.8 | -0.2 | -0.8 | -1.0 | 0.8 | -0.8 | 0.6 | -0.8 | -0.9 | -0.6 |
| Pavlov. Cond. lever latency | 0.4 | 0.5 | 1.2 | -0.5 | 0.9 | -0.4 | -0.9 | 0.6 | -0.3 | -0.7 | -1.1 | 0.7 | -0.7 | 0.6 | -1.1 | -0.5 | -0.4 |
| Intermittent access day 15 total infusions | 0.4 | 0.5 | 1.1 | 0.1 | -0.4 | 1.1 | 0.8 | 0.5 | 0.8 | 0.9 | 0.2 | -0.8 | 0.7 | 0.1 | 0.5 | 1.0 | 0.8 |
| Cocaine induced anxiety | 0.4 | 0.5 | 1.3 | 0.4 | 1.0 | -1.1 | -0.9 | 0.3 | -0.8 | -0.6 | -0.6 | 0.7 | -0.8 | -0.4 | -0.7 | -0.6 | -0.6 |
| Total sessions with >9 infusions | 0.4 | 0.4 | 1.5 | 1.2 | 0.6 | -0.1 | 1.0 | -0.3 | -0.4 | 0.6 | 0.7 | -0.3 | 0.1 | -0.6 | 0.7 | 0.7 | 0.2 |
| Short access day 1 total inactive lever presses | 0.4 | 0.4 | 0.8 | 0.4 | -0.3 | 0.5 | 0.9 | -0.3 | 0.4 | 0.7 | 0.8 | -0.8 | 0.7 | -0.3 | 0.9 | 0.9 | 0.5 |
| Number of responses in last shaping day | 0.4 | 0.4 | 1.1 | 0.2 | -0.3 | 0.2 | 0.9 | 0.2 | 0.4 | 0.8 | 0.5 | -0.9 | 0.8 | 0.2 | 0.7 | 1.0 | 0.6 |
| Locomotion velocity, session 3 | 0.4 | 0.5 | 1.4 | 0.4 | 0.5 | -1.1 | -0.3 | -0.9 | -1.2 | -0.7 | -0.1 | 0.7 | -0.7 | -0.6 | -0.3 | -0.8 | -0.8 |
| Stereotopy head waving bouts, day 3 | 0.4 | 0.5 | 1.3 | 0.1 | 1.1 | -1.2 | -0.9 | -0.2 | -0.8 | -0.5 | -0.4 | 0.8 | -0.9 | -0.2 | -0.6 | -0.6 | -0.6 |
| Locomotion velocity, session 7 | 0.4 | 0.4 | 0.8 | -0.7 | 0.4 | -0.5 | -0.8 | 0.2 | -0.6 | -0.6 | -0.9 | 0.7 | -0.6 | 0.5 | -0.9 | -0.7 | -0.6 |
| Stereotopy head waving bouts, day 7 | 0.4 | 0.4 | 1.5 | 0.0 | 0.3 | -1.2 | -0.6 | -0.7 | -1.0 | -0.5 | -0.1 | 0.7 | -0.6 | -0.3 | -0.4 | -0.8 | -0.8 |
| Degree of sensitization distance | 0.4 | 0.4 | 1.2 | 0.2 | -0.1 | 1.1 | 0.6 | 0.8 | 0.8 | 0.9 | -0.0 | -0.5 | 0.4 | 0.4 | 0.3 | 0.6 | 0.6 |
| Locomotion velocity, hab. session 1 | 0.4 | 0.6 | 1.7 | 0.6 | 0.1 | 1.0 | 0.9 | 0.2 | 0.6 | 1.3 | 0.8 | -0.7 | 0.6 | -0.0 | 1.0 | 0.8 | 0.7 |
| Total locomotion distance, hab. session 2 | 0.4 | 0.5 | 1.6 | 0.2 | 0.3 | 1.0 | 0.9 | 1.0 | 0.5 | 1.3 | 0.1 | -0.5 | 0.4 | 0.4 | 0.4 | 0.8 | 0.7 |
| Area under the delay curve | 0.4 | 0.4 | 2.3 | 1.5 | 0.8 | -0.1 | 0.1 | -0.6 | -0.0 | 0.2 | 0.8 | -0.0 | -0.0 | -1.1 | 0.8 | 0.2 | 0.3 |
| Delay disc. indifference point, 16s delay | 0.4 | 0.4 | 1.6 | 1.3 | 0.6 | -0.1 | 0.5 | -0.1 | 0.1 | 0.6 | 0.8 | -0.4 | 0.2 | -0.7 | 0.9 | 0.6 | 0.6 |
| Change in fecal boli incidents, locomotor task | 0.4 | 0.4 | 1.9 | 0.4 | 1.4 | -0.5 | -0.4 | 0.8 | -0.5 | -0.4 | -0.9 | 0.5 | -0.4 | -0.2 | -0.8 | -0.3 | -0.3 |
| Weight adjusted by age | 0.4 | 0.4 | 0.8 | 0.9 | 0.7 | -0.7 | -0.4 | -0.7 | -0.7 | -0.7 | -0.1 | 0.7 | -0.8 | -0.9 | -0.1 | -0.6 | -0.5 |
| Seeking ratio, delayed vs. immediate footshock | 0.4 | 0.5 | 1.8 | -1.0 | 0.0 | 0.3 | 0.5 | 1.3 | 0.1 | 0.4 | -1.0 | -0.3 | 0.2 | 1.3 | -0.5 | 0.3 | 0.3 |
| BMI with tail | 0.3 | 0.9 | 4.3 | -0.2 | 1.5 | -0.0 | 1.0 | 2.1 | -0.7 | 0.9 | -1.3 | -0.0 | -0.3 | 1.0 | -1.0 | 0.6 | 0.3 |
| Number of licking bursts | 0.3 | 0.3 | 1.3 | 0.9 | -0.3 | -0.0 | -0.1 | -1.1 | -0.1 | -0.3 | 0.7 | 0.1 | -0.1 | -1.1 | 0.5 | -0.0 | -0.2 |
| Delay discounting time to switch 0 sec | 0.3 | 0.5 | 1.3 | -1.2 | -0.2 | -0.5 | -1.0 | 0.6 | -0.1 | -0.7 | -1.0 | 0.5 | -0.3 | 0.9 | -0.9 | -0.8 | -0.6 |
| Light reinforcement 1 | 0.3 | 0.5 | 1.6 | 0.3 | 0.8 | 0.1 | 1.3 | 0.9 | -0.1 | 1.0 | -0.1 | -0.6 | 0.5 | 0.5 | 0.2 | 1.0 | 0.7 |
| Pavlov. Cond. latency score | 0.3 | 0.3 | 1.4 | 0.6 | -0.6 | -0.4 | -0.0 | -1.2 | -0.4 | -0.2 | 0.7 | 0.2 | -0.0 | -1.0 | 0.4 | -0.5 | -0.5 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.3 | 0.4 | 1.3 | 0.7 | -0.6 | -0.3 | 0.0 | -1.2 | -0.3 | -0.2 | 0.8 | 0.2 | -0.0 | -1.2 | 0.5 | -0.5 | -0.4 |
| Intermittent access intake escalation | 0.3 | 0.3 | 1.1 | -1.0 | -0.8 | 0.6 | -0.1 | 1.1 | 0.6 | 0.1 | -0.6 | -0.3 | 0.4 | 0.6 | -0.5 | 0.1 | 0.2 |
| Locomotion velocity, session 1 | 0.3 | 0.4 | 0.8 | 0.4 | -0.2 | 0.6 | 0.4 | -0.1 | 0.7 | 0.7 | 0.7 | -0.7 | 0.6 | -0.1 | 0.9 | 0.8 | 0.6 |
| Locomotion distance, session 3 | 0.3 | 0.3 | 1.4 | 0.7 | -0.2 | -0.2 | 0.0 | -1.2 | -0.2 | -0.2 | 0.7 | 0.1 | -0.0 | -0.9 | 0.5 | -0.3 | -0.2 |
| Locomotion velocity, hab. session 2 | 0.3 | 0.4 | 1.5 | 0.5 | 0.4 | 1.0 | 0.9 | 0.7 | 0.4 | 1.2 | 0.3 | -0.5 | 0.3 | 0.1 | 0.6 | 0.7 | 0.7 |
| Locomotion velocity, NPP test | 0.3 | 0.4 | 1.0 | 0.8 | 0.9 | 0.7 | 0.7 | 0.7 | 0.2 | 1.0 | 0.3 | -0.3 | 0.1 | -0.0 | 0.6 | 0.7 | 0.6 |
| Bone: trabecular spacing | 0.3 | 0.4 | 1.6 | -1.2 | -0.4 | 0.0 | -0.1 | 0.8 | -0.3 | -0.4 | -0.9 | 0.2 | -0.1 | 0.9 | -1.0 | -0.3 | -0.4 |
| Delta time in open arm before/after self-admin | 0.3 | 0.3 | 1.0 | -0.3 | 0.6 | -0.2 | 0.1 | 0.9 | -0.4 | 0.0 | -1.0 | 0.1 | -0.4 | 0.5 | -0.8 | 0.2 | -0.2 |
| Delta distance traveled before/after self-admin | 0.3 | 0.3 | 0.9 | -0.9 | -0.2 | -0.6 | 0.1 | 0.4 | -0.6 | -0.5 | -0.9 | 0.2 | 0.0 | 0.8 | -0.5 | -0.4 | -0.5 |
| Time in open arm after self-admin | 0.3 | 0.3 | 1.1 | -0.2 | 0.2 | 0.4 | 0.5 | 1.1 | 0.4 | 0.8 | -0.1 | -0.4 | 0.2 | 0.6 | 0.0 | 0.7 | 0.7 |
| Time to tail flick, test, after self-admin | 0.3 | 0.3 | 0.7 | 0.8 | 0.8 | -0.7 | -0.5 | -0.4 | -0.5 | -0.4 | -0.0 | 0.5 | -0.5 | -0.8 | -0.1 | -0.4 | -0.4 |
| Ambulatory time after self-admin | 0.3 | 0.3 | 1.4 | 0.3 | -0.8 | -0.2 | 0.3 | -1.2 | -0.0 | -0.1 | 1.0 | -0.2 | 0.4 | -0.5 | 0.8 | -0.0 | -0.1 |
| Distance moved, locomotor task time 1 | 0.3 | 0.3 | 0.6 | -0.1 | -0.4 | 0.7 | 0.8 | 0.6 | 0.6 | 0.7 | 0.5 | -0.6 | 0.7 | 0.3 | 0.6 | 0.5 | 0.7 |
| Time >=10cm from walls, locomotor time 2 | 0.3 | 0.3 | 0.9 | -0.5 | -0.5 | -0.5 | -1.0 | -0.1 | -0.2 | -0.9 | -0.4 | 0.4 | -0.3 | -0.1 | -0.6 | -0.6 | -0.7 |
| Run reversals in cocaine runway, males | 0.3 | 0.2 | 0.6 | 0.5 | 0.5 | -0.6 | -0.5 | -0.6 | -0.4 | -0.4 | 0.2 | 0.5 | -0.6 | -0.8 | -0.0 | -0.5 | -0.3 |
| Latency to leave start box in cocaine runway | 0.3 | 0.3 | 0.6 | -0.2 | 0.2 | -0.8 | -0.6 | -0.4 | -0.7 | -0.7 | -0.5 | 0.7 | -0.7 | -0.1 | -0.5 | -0.7 | -0.7 |
| Latency to leave start box in cocaine runway, M | 0.3 | 0.3 | 1.1 | -1.0 | -0.4 | 0.5 | -0.2 | 0.5 | 0.4 | 0.1 | -0.7 | -0.2 | 0.2 | 0.9 | -0.5 | 0.3 | 0.1 |
| Cu content in liver | 0.3 | 0.4 | 1.1 | -0.8 | -0.1 | 0.3 | 0.3 | 0.9 | 0.6 | 0.7 | -0.3 | -0.6 | 0.6 | 1.0 | -0.1 | 0.7 | 0.8 |
| Mg content in liver | 0.3 | 0.4 | 0.9 | 0.4 | -0.7 | 0.6 | 0.4 | -0.6 | 0.7 | 0.1 | 0.9 | -0.5 | 0.5 | -0.6 | 0.7 | 0.5 | 0.6 |
| Heart weight | 0.2 | 0.3 | 1.6 | 1.3 | 0.7 | -0.3 | 0.1 | -0.5 | -0.5 | 0.2 | 0.3 | 0.2 | -0.3 | -0.9 | 0.2 | 0.1 | -0.2 |
| Reaction time omissions | 0.2 | 0.2 | 0.9 | 0.3 | 0.9 | -0.2 | -0.8 | 0.6 | 0.1 | -0.6 | -0.5 | 0.4 | -0.5 | 0.0 | -0.2 | -0.3 | -0.1 |
| Reaction time premature initiations | 0.2 | 0.3 | 0.9 | 0.7 | 0.6 | 0.2 | 0.7 | 0.2 | -0.0 | 0.7 | 0.5 | -0.5 | 0.2 | -0.1 | 0.4 | 1.0 | 0.5 |
| Social response proportion | 0.2 | 0.2 | 0.4 | 0.5 | 0.6 | -0.4 | -0.5 | -0.2 | -0.5 | -0.4 | -0.2 | 0.5 | -0.6 | -0.5 | -0.5 | -0.3 | -0.5 |
| Cocaine response before conditioning | 0.2 | 0.3 | 1.5 | -0.1 | -0.6 | -0.8 | -0.3 | -1.2 | -0.5 | -0.4 | 0.2 | 0.2 | -0.1 | -0.6 | 0.1 | -0.5 | -0.6 |
| Pavlov. Cond. index score | 0.2 | 0.3 | 1.0 | 0.6 | -0.7 | -0.2 | 0.1 | -1.0 | -0.2 | -0.1 | 0.8 | 0.1 | 0.1 | -0.9 | 0.5 | -0.4 | -0.3 |
| Pavlov. Cond. lever contacts | 0.2 | 0.3 | 0.7 | 0.4 | -0.6 | 0.3 | 0.8 | -0.2 | 0.3 | 0.6 | 0.7 | -0.5 | 0.6 | -0.3 | 0.8 | 0.4 | 0.4 |
| Locomotion distance, session 1 | 0.2 | 0.2 | 1.1 | 1.1 | 0.9 | 0.1 | 0.1 | -0.2 | -0.2 | 0.5 | 0.3 | 0.3 | -0.4 | -0.5 | 0.4 | -0.1 | -0.1 |
| Stereotopy head waving duration, day 3 | 0.2 | 0.3 | 0.7 | 0.5 | 0.9 | -0.8 | -0.4 | -0.5 | -0.8 | -0.4 | 0.1 | 0.6 | -0.7 | -0.4 | -0.2 | -0.3 | -0.5 |
| Locomotion distance, session 8 | 0.2 | 0.2 | 0.8 | -0.2 | -0.9 | 0.6 | 0.9 | -0.1 | 0.1 | 0.6 | 0.3 | -0.4 | 0.5 | 0.3 | 0.4 | 0.3 | 0.2 |
| Condit. Reinf. lever presses | 0.2 | 0.3 | 1.1 | -0.3 | -1.0 | 0.2 | 0.6 | 0.2 | 0.5 | 0.2 | 0.5 | -0.8 | 1.0 | -0.0 | 0.6 | 0.6 | 0.5 |
| Total locomotion distance, hab. session 1 | 0.2 | 0.2 | 1.1 | 0.4 | 0.4 | 0.6 | 0.6 | 0.4 | 0.2 | 1.0 | 0.4 | -0.4 | 0.3 | 0.1 | 0.6 | 0.5 | 0.4 |
| Total zone transitions, NPP test | 0.2 | 0.3 | 1.6 | 1.3 | 0.7 | 0.0 | 0.5 | -0.4 | -0.5 | 0.5 | 0.6 | 0.1 | -0.3 | -0.8 | 0.6 | 0.1 | -0.1 |
| Total locomotion distance, NPP test | 0.2 | 0.3 | 0.8 | 0.7 | 0.4 | 0.8 | 0.6 | 0.4 | 0.4 | 0.9 | 0.5 | -0.3 | 0.2 | -0.1 | 0.7 | 0.5 | 0.4 |
| Bone: elastic work | 0.2 | 0.3 | 1.0 | -0.1 | 1.0 | -0.8 | -0.5 | -0.1 | -0.6 | -0.5 | -0.5 | 0.4 | -0.5 | -0.0 | -0.5 | -0.3 | -0.4 |
| Delta time in closed arm before/after self-admin | 0.2 | 0.2 | 1.1 | 0.3 | -0.3 | 0.0 | -0.5 | -1.0 | 0.1 | -0.4 | 0.7 | 0.2 | -0.0 | -0.7 | 0.3 | -0.4 | -0.3 |
| Rest time, locomotor task time 1 | 0.2 | 0.2 | 0.7 | -0.2 | 0.5 | -0.5 | -0.8 | 0.1 | -0.2 | -0.5 | -0.6 | 0.4 | -0.3 | 0.0 | -0.5 | -0.3 | -0.3 |
| Soleus weight | 0.1 | 0.3 | 0.8 | 0.5 | -0.3 | -0.2 | 0.9 | -0.6 | -0.1 | 0.2 | 0.7 | -0.6 | 0.5 | -0.4 | 0.8 | 0.5 | 0.4 |
| Mean time between licks in bursts | 0.1 | 0.2 | 0.7 | 0.9 | 0.4 | 0.4 | 0.3 | -0.3 | 0.3 | 0.4 | 0.6 | -0.1 | -0.0 | -0.5 | 0.6 | 0.3 | 0.4 |
| Std. dev. time between licks in bursts | 0.1 | 0.2 | 0.8 | -0.5 | 0.3 | 0.1 | 0.1 | 0.9 | 0.1 | -0.1 | -0.6 | -0.1 | -0.1 | 0.7 | -0.4 | 0.3 | 0.2 |
| Social time | 0.1 | 0.1 | 0.2 | -0.1 | -0.4 | -0.0 | -0.3 | 0.3 | 0.4 | 0.3 | 0.1 | -0.3 | 0.3 | 0.1 | -0.1 | 0.3 | 0.2 |
| Pavlov. Cond. response bias | 0.1 | 0.2 | 0.7 | 0.8 | -0.3 | 0.0 | 0.3 | -0.7 | -0.1 | 0.1 | 0.7 | 0.0 | 0.1 | -0.8 | 0.6 | -0.2 | -0.1 |
| Context. condit. distance diff. score | 0.1 | 0.1 | 0.4 | -0.6 | -0.5 | 0.2 | 0.4 | 0.1 | -0.2 | 0.2 | -0.4 | -0.0 | 0.1 | 0.5 | -0.3 | -0.0 | -0.1 |
| Locomotion distance, session 2 | 0.1 | 0.2 | 0.4 | 0.6 | -0.3 | 0.2 | 0.3 | -0.6 | -0.2 | 0.1 | 0.7 | 0.0 | 0.1 | -0.5 | 0.6 | -0.2 | -0.3 |
| Total zone transitions, hab. session 1 | 0.1 | 0.1 | 0.5 | 0.4 | 0.2 | 0.6 | 0.6 | 0.3 | -0.0 | 0.7 | 0.1 | -0.2 | 0.1 | 0.0 | 0.3 | 0.3 | 0.2 |
| Total zone transitions, hab. session 2 | 0.1 | 0.1 | 0.5 | -0.0 | -0.3 | 0.5 | 0.7 | 0.4 | 0.0 | 0.6 | 0.1 | -0.3 | 0.2 | 0.1 | 0.2 | 0.3 | 0.2 |
| Novel to familiar place preference ratio | 0.1 | 0.1 | 0.3 | 0.3 | 0.0 | 0.3 | 0.4 | -0.0 | 0.3 | 0.1 | 0.5 | -0.4 | 0.4 | -0.4 | 0.4 | 0.5 | 0.5 |
| Delta ambulatory time before/after self-admin | 0.1 | 0.1 | 0.3 | -0.4 | -0.3 | 0.0 | 0.5 | 0.3 | 0.1 | 0.1 | -0.2 | -0.3 | 0.4 | 0.5 | 0.2 | 0.1 | 0.1 |
| Sum of active levers in priming session hrs 5-6 | 0.1 | 0.1 | 0.2 | -0.3 | -0.5 | -0.2 | 0.3 | 0.2 | -0.4 | -0.2 | -0.2 | -0.1 | -0.0 | 0.3 | -0.3 | 0.1 | -0.2 |
| Fecal boli incidents, locomotor time 1 | 0.1 | 0.1 | 0.3 | 0.2 | -0.2 | 0.2 | 0.1 | -0.3 | 0.2 | 0.2 | 0.5 | -0.1 | -0.0 | -0.2 | 0.3 | 0.1 | 0.3 |
| Vertical activity count, locomotor time 1 | 0.1 | 0.1 | 0.4 | 0.4 | -0.3 | 0.3 | 0.4 | -0.2 | 0.3 | 0.2 | 0.6 | -0.3 | 0.4 | -0.2 | 0.6 | 0.2 | 0.3 |
| Fe content in liver | 0.1 | 0.1 | 0.3 | -0.1 | -0.1 | -0.5 | 0.0 | -0.0 | -0.5 | -0.5 | -0.2 | 0.3 | -0.2 | 0.1 | -0.1 | -0.4 | -0.4 |
| Sr content in liver | 0.1 | 0.1 | 0.4 | 0.4 | 0.1 | 0.1 | 0.2 | -0.6 | 0.1 | 0.6 | 0.6 | -0.2 | 0.2 | -0.3 | 0.5 | 0.3 | 0.2 |
| Water consumed over 24 hours | 0.0 | 0.0 | 0.4 | 0.3 | 0.6 | 0.1 | 0.1 | 0.2 | -0.1 | 0.2 | -0.2 | 0.0 | -0.1 | -0.1 | -0.1 | 0.2 | 0.0 |
| Social responses | 0.0 | 0.1 | 0.3 | 0.2 | -0.4 | 0.2 | 0.6 | -0.0 | -0.1 | 0.2 | 0.2 | -0.3 | 0.3 | -0.1 | 0.1 | 0.2 | 0.0 |
| Locomotion distance, session 7 | 0.0 | 0.0 | 0.2 | 0.3 | -0.0 | 0.3 | 0.2 | 0.3 | 0.0 | 0.5 | -0.2 | 0.1 | -0.0 | 0.1 | -0.0 | -0.1 | -0.0 |
| Novelty place preference | 0.0 | 0.0 | 0.1 | 0.2 | 0.0 | 0.1 | 0.3 | -0.1 | 0.1 | -0.2 | 0.3 | -0.2 | 0.2 | -0.3 | 0.2 | 0.2 | 0.3 |
| Time in novel zone, NPP test | 0.0 | 0.0 | 0.1 | 0.2 | -0.0 | -0.1 | 0.1 | -0.2 | -0.0 | -0.3 | 0.3 | -0.1 | 0.1 | -0.4 | 0.1 | 0.0 | 0.1 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.