Hub : Genes

Lancl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000013557 0.56 0.15 0.0e+00 0.21 0.18 0.21 0.21 2.3e-23 6.6e-20 1.4e-22 5.6e-23
2 BLA gene expression ENSRNOG00000013557 0.39 0.11 0.0e+00 0.35 0.34 0.34 0.34 2.2e-19 1.1e-18 9.4e-19 5.1e-19
3 Brain gene expression ENSRNOG00000013557 0.27 0.04 0.0e+00 0.55 0.54 0.56 0.56 7.6e-61 4.9e-59 4.0e-62 2.0e-61
4 Brain mRNA stability ENSRNOG00000013557 0.08 0.04 1.8e-06 0.07 0.06 0.06 0.06 2.1e-07 1.9e-06 7.5e-06 1.8e-06
5 Eye gene expression ENSRNOG00000013557 0.36 0.17 2.5e-03 0.08 0.08 0.02 0.04 2.6e-02 2.3e-02 1.4e-01 7.6e-02
6 IL gene expression ENSRNOG00000013557 0.52 0.13 4.0e-12 0.4 0.46 0.45 0.43 1.2e-10 1.4e-12 2.4e-12 1.1e-11
7 LHb gene expression ENSRNOG00000013557 0.54 0.13 3.2e-12 0.36 0.4 0.38 0.4 2.3e-09 1.3e-10 4.8e-10 1.7e-10
8 Liver gene expression ENSRNOG00000013557 0.59 0.11 0.0e+00 0.34 0.34 0.34 0.34 1.5e-38 1.6e-38 5.7e-39 1.0e-38
9 Liver mRNA stability ENSRNOG00000013557 0.04 0.03 8.2e-05 0.01 0.01 0.01 0.01 1.0e-02 1.3e-02 1.8e-02 3.1e-02
10 NAcc gene expression ENSRNOG00000013557 0.4 0.15 0.0e+00 0.28 0.34 0.34 0.34 6.4e-21 2.8e-26 5.7e-26 2.5e-26
11 OFC gene expression ENSRNOG00000013557 0.45 0.14 8.4e-10 0.43 0.3 0.33 0.33 2.2e-11 6.8e-08 1.3e-08 1.0e-08
12 PL gene expression ENSRNOG00000013557 0.38 0.11 0.0e+00 0.39 0.4 0.41 0.41 6.3e-31 1.2e-32 4.8e-33 5.1e-33

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
BMI with tail1.65.28.7-0.3-2.8-2.6-2.8-1.4-1.8-0.9-2.8-2.9-1.7-2.9-2.4
BMI without tail0.10.20.50.6-0.4-0.6-0.6-0.0-0.20.2-0.5-0.7-0.0-0.5-0.4
Body weight0.72.84.82.21.41.61.52.11.81.41.41.51.91.61.5
Epididymis fat weight3.48.010.83.32.52.82.53.33.12.72.62.63.02.62.8
Glucose0.10.20.60.80.10.20.10.70.50.70.10.00.40.10.3
Heart weight0.50.71.8-1.4-0.5-0.6-0.5-0.9-0.7-0.9-0.6-0.8-1.2-0.5-0.9
Left kidney weight0.10.30.60.70.50.50.60.80.70.40.60.50.60.60.6
Right kidney weight1.02.93.71.51.61.71.71.91.91.51.61.61.81.81.8
Tail length7.923.930.43.45.45.25.44.44.73.55.45.44.65.55.0
Length with tail7.025.532.73.65.55.55.64.74.93.25.55.74.85.75.2
Length without tail1.43.13.81.51.61.91.82.01.91.21.71.91.81.81.9
Liver weight, left0.20.30.6-0.40.70.60.70.10.3-0.40.70.70.10.80.4
Liver weight, right0.40.72.2-1.4-0.5-0.4-0.4-0.9-0.7-1.5-0.5-0.3-1.1-0.5-0.5
Parametrial fat weight2.95.66.51.72.52.52.52.42.51.72.52.42.42.52.5
Retroperitoneal fat weight0.31.13.11.80.60.90.81.41.11.00.70.81.30.71.0
Intraocular pressure1.52.12.7-1.1-1.5-1.5-1.5-1.4-1.5-1.2-1.5-1.6-1.2-1.5-1.4
Extensor digitorum longus weight0.10.51.41.2-0.5-0.3-0.60.80.41.2-0.5-0.80.2-0.80.0
Soleus weight0.00.00.0-0.10.0-0.10.0-0.1-0.1-0.00.1-0.10.1-0.10.1
Tibialis anterior weight0.00.10.40.7-0.1-0.2-0.10.30.10.6-0.1-0.30.2-0.3-0.1
Tibia length1.85.06.81.42.42.52.62.12.31.52.42.61.92.52.4
Number of licking bursts0.30.40.80.70.50.50.50.90.80.90.40.20.70.40.5
Food consumed during 24 hour testing period0.50.61.6-1.3-0.5-0.8-0.5-1.0-0.9-1.3-0.5-0.5-0.7-0.5-0.5
Times rat made contact with spout0.60.72.4-1.6-0.5-0.6-0.5-1.1-0.9-1.3-0.5-0.5-0.9-0.5-0.5
Mean time between licks in bursts0.71.01.5-0.7-1.2-1.0-1.2-0.7-0.8-0.8-1.2-1.2-0.9-1.1-0.8
Mean num. licks in bursts0.81.02.0-1.4-0.7-0.8-0.8-1.3-1.2-1.4-0.7-0.5-1.0-0.7-0.7
Std. dev. time between licks in bursts0.60.81.60.2-1.2-1.0-1.3-0.4-0.6-0.0-1.2-1.0-0.4-1.2-0.6
Water consumed over 24 hours0.80.91.2-1.1-1.0-1.0-0.9-0.9-0.9-0.7-0.9-1.1-0.9-0.9-0.8
Indifference point 0 sec0.10.10.40.2-0.5-0.1-0.40.20.10.3-0.5-0.6-0.2-0.4-0.1
Indifference point AUC0.20.20.30.40.50.40.40.40.30.30.50.50.50.60.6
Indifference point function ln k1.72.53.3-1.0-1.8-1.6-1.7-1.4-1.5-1.4-1.8-1.7-1.4-1.8-1.6
Indifference point function log k1.72.53.3-1.0-1.8-1.6-1.7-1.4-1.5-1.4-1.8-1.7-1.4-1.8-1.6
Delay discounting total patch changes 0 sec0.10.20.6-0.0-0.6-0.3-0.6-0.1-0.10.1-0.6-0.8-0.3-0.6-0.4
Delay discounting total patch changes 12 sec0.00.10.1-0.3-0.3-0.2-0.1-0.3-0.3-0.2-0.2-0.2-0.2-0.2-0.1
Delay discounting total patch changes 18 sec0.00.10.20.1-0.2-0.1-0.40.10.00.4-0.2-0.50.0-0.2-0.1
Delay discounting total patch changes 24 sec0.20.20.4-0.4-0.6-0.4-0.6-0.4-0.4-0.3-0.5-0.5-0.5-0.5-0.4
Delay discounting total patch changes 6 sec0.10.20.80.9-0.10.20.00.60.50.8-0.0-0.20.50.00.2
Delay discounting time to switch 0 sec0.10.10.2-0.30.50.20.5-0.00.1-0.20.40.3-0.10.4-0.1
Delay discounting water rate 0 sec0.40.71.81.30.40.60.50.90.71.10.50.61.00.50.9
Delay discounting water rate 12 sec0.81.21.8-0.9-1.0-1.2-1.1-1.1-1.1-0.7-1.0-1.3-1.1-1.0-1.4
Delay discounting water rate 18 sec0.30.41.0-0.9-0.6-0.5-0.3-0.9-0.8-1.0-0.5-0.3-0.7-0.5-0.5
Delay discounting water rate 24 sec0.20.20.40.50.50.40.40.40.30.50.50.40.60.50.4
Delay discounting water rate 6 sec0.60.81.3-0.0-1.1-1.0-1.1-0.7-0.9-0.1-1.2-1.1-0.7-1.2-0.9
Locomotor activity0.50.81.8-1.1-0.9-0.8-1.0-0.5-0.6-0.6-1.0-1.3-0.9-0.9-0.9
Locomotor testing distance0.30.40.8-0.8-0.8-0.6-0.7-0.5-0.5-0.4-0.7-0.9-0.6-0.8-0.4
Locomotor testing rearing0.10.20.3-0.5-0.6-0.3-0.3-0.4-0.4-0.5-0.5-0.5-0.5-0.5-0.3
Light reinforcement 10.81.52.2-0.4-1.4-1.5-1.4-1.2-1.4-1.0-1.4-1.3-0.9-1.3-1.2
Light reinforcement 20.10.10.3-0.20.50.20.5-0.1-0.0-0.30.50.40.10.40.0
Reaction time number correct1.31.82.2-1.0-1.5-1.4-1.5-1.3-1.4-0.8-1.5-1.4-1.3-1.5-1.5
Reaction time mean minus median0.10.20.6-0.5-0.2-0.3-0.1-0.6-0.5-0.8-0.2-0.0-0.4-0.3-0.2
Reaction time mean minus median AUC0.30.41.0-0.8-0.4-0.5-0.3-0.8-0.8-1.0-0.4-0.2-0.7-0.4-0.4
Reaction time num false alarms0.40.61.30.3-1.0-0.8-1.0-0.3-0.5-0.2-1.0-1.1-0.3-1.1-0.7
Reaction time num false alarms AUC0.20.30.50.6-0.7-0.5-0.60.0-0.20.1-0.7-0.70.0-0.7-0.4
Reaction time trials correct on left1.31.82.2-1.0-1.5-1.4-1.5-1.3-1.4-0.8-1.5-1.4-1.3-1.5-1.5
Reaction time trials on left1.11.62.0-0.9-1.4-1.3-1.4-1.2-1.3-0.7-1.4-1.4-1.2-1.4-1.4
Reaction time mean0.50.71.4-0.51.21.01.00.30.6-0.21.11.20.31.00.9
Reaction time mean AUC0.91.22.1-0.11.41.31.30.71.00.31.41.50.71.31.2
Median of all reaction times1.31.72.9-0.11.71.51.40.91.20.41.61.70.81.61.5
Reaction time omissions0.91.21.71.01.11.11.11.11.10.71.11.31.11.11.1
Reaction time false alarm rate0.30.51.51.20.40.50.41.00.80.70.40.30.90.30.6
Reaction time premature initiation rate0.71.02.4-1.5-0.9-0.8-0.7-1.0-0.9-1.1-0.8-0.9-1.2-0.8-0.8
Reaction time premature initiations2.33.34.4-2.1-1.8-1.7-1.6-1.9-1.8-1.7-1.7-1.8-2.0-1.7-1.8
Std. dev. reaction times0.20.20.6-0.40.50.40.6-0.10.0-0.60.50.80.10.50.5
Reaction time trials completed1.11.62.0-0.9-1.4-1.3-1.4-1.2-1.3-0.7-1.4-1.4-1.2-1.4-1.4
Reaction time trials AUC1.11.51.9-1.0-1.3-1.3-1.3-1.2-1.3-0.8-1.4-1.3-1.2-1.3-1.4
Social response proportion0.40.40.70.70.60.50.50.80.70.60.60.60.70.50.6
Social responses0.20.20.40.10.60.50.50.50.60.20.60.40.50.60.5
Social time0.20.30.5-0.6-0.6-0.6-0.6-0.6-0.6-0.7-0.5-0.4-0.6-0.5-0.4
Conditioned locomotion0.70.91.00.91.00.90.81.01.01.01.00.90.91.00.9
Cocaine response after cond. corrected0.10.10.2-0.30.40.30.3-0.00.10.00.30.30.10.40.2
Cocaine response after cond. not corrected0.60.71.10.21.01.00.90.60.80.51.01.00.71.10.9
Cocaine response before conditioning1.62.02.71.21.31.41.41.71.61.41.31.21.41.31.5
Saline control response0.30.40.8-0.3-0.7-0.6-0.9-0.2-0.30.1-0.7-0.9-0.5-0.7-0.6
Condit. Reinf. active minus inactive responses3.64.56.40.72.52.42.51.82.11.62.42.31.72.52.1
Condit. Reinf. active-inactive response ratio3.73.95.60.72.32.22.41.51.81.32.32.21.72.32.0
Condit. Reinf. active responses2.02.73.80.31.91.91.91.51.71.31.91.71.21.91.7
Condit. Reinf. inactive responses0.00.10.2-0.20.20.30.20.30.40.20.10.00.10.20.3
Condit. Reinf. lever presses0.10.20.8-0.9-0.2-0.2-0.2-0.5-0.4-0.6-0.2-0.4-0.6-0.2-0.3
Condit. Reinf. lever reinforcers received2.23.24.40.52.12.12.11.61.81.32.01.91.42.11.8
Pavlov. Cond. lever latency0.50.62.01.40.50.50.41.00.81.00.50.61.00.50.7
Pavlov. Cond. magazine entry latency1.21.42.5-1.4-0.9-1.1-0.8-1.6-1.5-1.5-0.9-0.9-1.2-0.9-1.2
Pavlov. Cond. change in total contacts0.20.21.0-1.0-0.1-0.2-0.1-0.7-0.5-0.7-0.1-0.2-0.6-0.1-0.4
Pavlov. Cond. index score1.21.53.7-1.9-0.8-0.9-0.7-1.6-1.3-1.6-0.8-0.9-1.5-0.8-1.1
Pavlov. Cond. latency score0.81.02.7-1.6-0.6-0.7-0.6-1.3-1.1-1.4-0.6-0.7-1.2-0.6-0.9
Pavlov. Cond. lever contacts0.30.41.9-1.4-0.2-0.2-0.1-0.8-0.6-0.9-0.2-0.3-0.8-0.2-0.4
Pavlov. Cond. magazine entry number1.82.24.01.91.21.31.11.91.82.01.21.01.61.21.4
Pavlov. Cond. intertrial magazine entries4.25.49.13.01.82.01.72.92.73.01.81.72.51.82.2
Pavlov. Cond. lever-magazine prob. diff.1.72.24.6-2.2-1.1-1.2-1.0-1.9-1.6-1.9-1.1-1.2-1.7-1.1-1.4
Pavlov. Cond. response bias0.91.23.4-1.9-0.6-0.7-0.5-1.4-1.2-1.5-0.7-0.7-1.4-0.6-1.0
Conditioned reinforcement - actives0.00.00.10.3-0.2-0.1-0.20.30.20.3-0.1-0.10.0-0.1-0.0
Conditioned reinforcement - inactives0.50.60.90.10.70.80.70.90.90.70.70.70.70.80.8
Conditioned locomotion3.03.65.2-0.3-2.3-2.2-2.2-1.4-1.7-0.9-2.2-2.2-1.6-2.3-2.1
Intermittent access intake day 1-15 change0.40.40.6-0.2-0.7-0.8-0.7-0.5-0.6-0.3-0.7-0.7-0.6-0.7-0.7
Intermittent access intake escalation1.41.41.7-0.9-1.2-1.3-1.2-1.1-1.2-1.0-1.2-1.2-1.2-1.2-1.3
Intermittent access intake escalation 21.91.92.3-1.0-1.4-1.5-1.4-1.4-1.5-1.2-1.4-1.4-1.4-1.4-1.5
Intermitt. access day 1 inactive lever presses0.10.10.7-0.8-0.10.1-0.0-0.2-0.0-0.5-0.1-0.0-0.3-0.0-0.1
Intermitt. access day 15 inactive lever presses0.30.30.8-0.9-0.4-0.4-0.4-0.5-0.5-0.9-0.4-0.3-0.6-0.4-0.3
Intermitt. access escalation Index2.92.62.9-1.3-1.7-1.6-1.7-1.6-1.6-1.6-1.7-1.5-1.6-1.7-1.6
Intermittent access day 1 total infusions0.30.40.60.30.60.80.70.50.60.50.70.80.40.70.6
Intermittent access day 15 total infusions0.10.10.2-0.0-0.5-0.3-0.4-0.1-0.20.1-0.5-0.4-0.4-0.5-0.4
Intermittent access terminal intake (last 3 days)1.21.31.6-0.8-1.3-1.2-1.2-1.0-1.1-0.8-1.2-1.1-1.2-1.2-1.2
Intermittent access total infusions0.00.00.1-0.0-0.00.10.00.10.10.2-0.00.1-0.1-0.00.0
Intermittent access day 1 locomotion0.00.00.10.10.10.30.20.20.30.20.10.3-0.00.20.1
Intermittent access day 15 total locomotion0.50.50.7-0.5-0.8-0.8-0.8-0.6-0.6-0.4-0.8-0.7-0.8-0.8-0.8
Intermittent access total locomotion0.60.71.1-0.3-1.0-0.9-1.0-0.6-0.7-0.3-1.0-0.9-0.8-1.0-1.0
Intermittent access standard deviation2.12.23.2-1.8-1.4-1.4-1.4-1.4-1.3-1.5-1.4-1.4-1.8-1.4-1.6
Cocaine induced anxiety0.91.12.0-1.3-0.9-1.0-0.9-1.1-1.1-1.4-0.9-0.9-1.0-0.8-0.9
Post-drug Anxiety0.40.50.8-0.4-0.9-0.8-0.9-0.5-0.6-0.6-0.8-0.9-0.4-0.7-0.6
Baseline Anxiety0.60.72.01.20.40.60.41.00.91.40.50.50.90.40.8
Lifetime Intake0.00.00.10.30.00.10.10.30.20.40.00.20.1-0.00.1
Incentive Sensitization - Responses0.10.00.30.00.10.20.10.30.30.50.10.10.20.10.2
Incentive Sensitization - Breakpoint0.10.10.2-0.00.10.20.10.30.30.50.10.10.20.10.3
Progressive ratio test 1 active lever presses0.00.00.00.2-0.00.20.00.20.20.10.00.10.10.0-0.1
Progressive ratio test 1 breakpoint0.00.00.00.10.00.20.00.10.10.10.00.10.00.1-0.1
Progressive ratio test 1 inactive lever presses1.21.21.6-0.9-1.3-1.1-1.3-0.9-1.0-1.2-1.3-1.2-1.0-1.2-1.2
Progressive ratio test 2 active lever presses0.10.10.40.30.20.30.20.50.50.70.20.20.20.20.2
Progressive ratio test 2 breakpoint0.00.00.20.10.00.20.00.30.30.50.10.10.10.10.1
Progressive ratio test 2 inactive lever presses0.20.30.4-0.6-0.6-0.4-0.6-0.4-0.4-0.4-0.6-0.5-0.6-0.5-0.5
Total sessions with >9 infusions0.10.10.20.20.40.40.40.30.40.40.40.40.20.40.2
Short access day 1 total inactive lever presses0.00.00.10.2-0.10.00.00.30.20.3-0.00.00.1-0.00.1
Short access day 10 total inactive lever presses0.30.31.5-1.2-0.2-0.2-0.2-0.5-0.4-1.0-0.2-0.2-0.5-0.1-0.3
Short access day 1 total infusions0.30.30.70.0-0.8-0.7-0.7-0.3-0.4-0.1-0.8-0.7-0.4-0.8-0.6
Short access day 10 total infusions0.10.10.1-0.10.30.30.30.20.30.20.30.4-0.10.20.2
Short access total infusions0.10.10.30.2-0.5-0.4-0.4-0.1-0.20.1-0.5-0.4-0.2-0.5-0.4
Short access day 1 locomotion0.50.50.90.20.80.90.80.91.00.80.80.70.40.70.6
Short access day 10 total locomotion1.11.22.2-1.5-0.9-1.0-0.9-1.2-1.1-1.3-0.9-0.8-1.4-0.9-1.1
Short access total locomotion0.20.20.4-0.4-0.4-0.4-0.3-0.3-0.3-0.2-0.4-0.4-0.6-0.4-0.6
Compulsive drug intake0.00.00.3-0.60.10.20.1-0.2-0.0-0.30.10.1-0.10.10.0
One hour access (0.3 mA shock)0.40.41.0-1.0-0.5-0.5-0.5-0.7-0.6-0.7-0.5-0.3-0.9-0.5-0.7
One hour access (shock baseline)0.00.00.1-0.3-0.1-0.1-0.1-0.1-0.1-0.1-0.10.1-0.3-0.1-0.1
Number of responses in last shaping day4.64.75.91.82.12.32.12.42.42.12.12.12.12.22.2
Context. condit. distance diff. score0.00.00.20.30.1-0.00.10.20.10.20.10.00.40.10.2
Locomotion velocity, session 10.10.10.6-0.80.10.10.1-0.5-0.3-0.50.00.1-0.50.1-0.2
Locomotion distance, session 10.10.20.3-0.4-0.3-0.3-0.2-0.5-0.5-0.4-0.3-0.5-0.4-0.2-0.6
Locomotion velocity, session 21.72.03.21.71.21.41.31.71.71.81.21.11.41.11.3
Locomotion distance, session 20.20.30.6-0.4-0.6-0.6-0.6-0.5-0.6-0.5-0.7-0.8-0.5-0.6-0.6
Locomotion velocity, session 31.31.52.1-1.1-1.0-1.3-1.1-1.4-1.5-1.4-1.1-1.3-1.1-1.1-1.4
Locomotion distance, session 30.60.71.3-0.01.21.01.00.40.60.31.10.90.51.10.7
Stereotopy head waving bouts, day 39.110.912.3-2.8-3.5-3.4-3.4-3.3-3.4-3.0-3.5-3.5-3.2-3.5-3.3
Stereotopy head waving duration, day 36.47.89.2-2.0-3.0-3.0-2.9-2.7-2.9-2.5-3.0-3.0-2.5-2.9-2.8
Locomotion velocity, session 71.71.92.61.41.31.31.21.51.51.61.31.21.51.31.3
Locomotion distance, session 72.93.74.81.51.92.01.82.12.22.21.91.61.91.92.0
Stereotopy head waving bouts, day 70.10.10.40.60.10.20.20.20.10.30.10.30.40.20.2
Stereotopy head waving duration, day 70.10.10.80.9-0.3-0.4-0.3-0.0-0.30.0-0.2-0.10.4-0.3-0.2
Locomotion velocity, session 80.00.00.10.1-0.3-0.2-0.2-0.1-0.20.2-0.3-0.3-0.1-0.2-0.2
Locomotion distance, session 80.00.00.10.00.0-0.0-0.00.10.10.10.0-0.30.20.00.1
Degree of sensitization distance0.20.20.80.6-0.10.2-0.10.80.60.9-0.0-0.20.50.00.4
Degree of sensitization stereotypy1.51.63.41.91.11.11.11.31.21.41.11.21.51.11.1
Condit. Reinf. active minus inactive responses0.10.10.2-0.50.20.50.40.10.30.10.30.3-0.10.40.1
Condit. Reinf. active-inactive response ratio0.20.20.6-0.8-0.3-0.2-0.3-0.5-0.4-0.4-0.3-0.3-0.7-0.2-0.6
Condit. Reinf. active responses0.60.71.3-0.00.81.11.00.81.00.80.90.90.51.00.8
Condit. Reinf. inactive responses0.70.81.10.40.81.01.00.91.00.90.90.90.80.91.0
Incentive salience index mean0.30.40.80.00.60.90.80.60.70.60.70.70.40.70.6
Condit. Reinf. lever presses0.20.30.60.20.40.70.60.60.70.50.50.60.50.50.7
Time in familiar zone, hab. session 12.92.74.0-0.9-1.7-1.9-1.8-1.5-1.6-1.2-1.7-2.0-1.6-1.7-1.9
Time in novel zone, hab. session 11.51.52.9-0.21.41.51.50.60.90.21.41.70.81.41.4
Total zone transitions, hab. session 12.84.04.71.72.12.12.12.12.12.22.01.81.92.11.8
Total locomotion distance, hab. session 11.31.82.40.51.51.51.51.31.41.31.51.31.11.61.2
Locomotion velocity, hab. session 12.13.03.80.91.91.91.81.81.91.81.81.61.61.91.6
Time in familiar zone, hab. session 20.30.30.5-0.3-0.5-0.7-0.5-0.6-0.7-0.6-0.5-0.4-0.4-0.5-0.5
Time in novel zone, hab. session 20.00.00.1-0.00.10.30.10.20.20.20.00.00.00.10.2
Total zone transitions, hab. session 20.10.10.2-0.4-0.2-0.2-0.1-0.3-0.3-0.4-0.2-0.3-0.4-0.2-0.4
Total locomotion distance, hab. session 20.10.10.2-0.5-0.2-0.2-0.2-0.2-0.1-0.2-0.3-0.5-0.4-0.2-0.4
Locomotion velocity, hab. session 20.00.00.1-0.3-0.1-0.1-0.10.00.0-0.1-0.1-0.3-0.2-0.1-0.3
Novel to familiar place preference ratio3.03.23.91.52.01.81.81.81.81.61.91.71.82.01.7
Novelty place preference2.42.53.21.31.81.61.61.61.61.31.71.61.61.81.5
Time in novel zone, NPP test2.42.53.41.21.81.61.71.51.61.21.81.61.61.81.5
Total zone transitions, NPP test0.00.00.0-0.10.10.10.1-0.1-0.0-0.10.1-0.00.00.1-0.1
Total locomotion distance, NPP test0.10.10.2-0.20.40.40.30.20.30.30.30.00.20.40.1
Locomotion velocity, NPP test0.00.00.1-0.20.10.10.00.10.10.20.1-0.2-0.00.1-0.1
Pavlov. Cond. lever latency4.05.07.1-2.4-1.9-2.2-2.0-2.6-2.5-2.7-2.0-2.0-2.3-1.8-2.4
Pavlov. Cond. magazine entry latency2.83.64.11.71.91.92.01.91.91.91.92.01.81.91.8
Pavlov. Cond. change in total contacts4.64.97.22.71.92.12.22.42.32.72.02.12.21.82.1
Pavlov. Cond. index score3.54.55.22.02.02.22.12.22.22.32.02.12.12.02.2
Pavlov. Cond. latency score3.34.24.81.91.92.12.02.22.22.22.02.02.01.92.1
Pavlov. Cond. lever contacts1.41.62.51.31.01.31.11.51.51.61.11.11.20.91.4
Pavlov. Cond. magazine entry number3.54.44.9-2.0-2.1-2.2-2.2-2.1-2.1-2.2-2.1-2.2-1.9-2.0-2.0
Pavlov. Cond. intertrial magazine entries1.01.21.6-1.2-1.3-0.9-1.1-1.0-0.9-0.9-1.1-1.2-1.1-1.1-1.0
Pavlov. Cond. lever-magazine prob. diff.2.63.23.81.71.71.91.81.91.91.91.71.81.71.61.8
Pavlov. Cond. response bias2.53.03.61.61.71.91.81.81.81.81.71.81.61.61.8
Bone: apparent density0.61.11.40.91.11.01.10.90.90.91.11.21.01.11.0
Bone surface1.01.82.11.21.21.41.41.41.41.41.31.31.21.31.3
Bone volume1.62.73.51.21.81.71.81.51.61.31.81.91.51.91.6
Bone: connectivity density0.50.71.71.30.50.70.51.11.01.30.60.51.00.50.8
Bone: cortical apparent density2.83.65.9-1.2-2.4-1.9-2.3-1.4-1.5-1.0-2.3-2.3-1.7-2.3-1.7
Bone: cortical area0.91.31.80.70.91.31.11.21.31.31.11.21.01.21.3
Bone: cortical porosity3.43.76.00.52.32.12.31.41.70.82.32.31.62.42.0
Bone: cortical porosity3.63.96.40.42.42.22.41.51.80.82.42.31.62.52.0
Bone: cortical thickness0.61.02.10.90.61.20.91.11.21.40.81.00.90.91.1
Bone: cortical thickness0.00.10.3-0.50.00.20.1-0.2-0.0-0.20.10.3-0.10.30.1
Bone: cortical tissue density2.93.86.2-1.2-2.5-1.9-2.4-1.4-1.5-1.0-2.4-2.4-1.7-2.4-1.8
Bone: elastic displacement1.61.82.1-1.2-1.4-1.3-1.4-1.4-1.4-1.1-1.4-1.4-1.3-1.4-1.3
Bone: elastic work0.10.10.2-0.00.20.40.30.20.30.30.20.30.10.30.3
Bone: endosteal estimation0.61.22.10.31.41.21.40.81.00.31.41.30.91.51.1
Bone: endosteal perimeter0.10.20.4-0.00.60.40.60.20.3-0.20.60.60.30.60.4
Bone: final force0.71.12.00.41.11.21.40.81.00.51.21.30.91.41.1
Bone: final moment0.50.91.50.41.01.11.20.70.90.51.01.10.81.21.0
Bone: marrow area0.61.42.30.41.51.31.50.91.00.41.41.31.01.51.2
Bone: maximum diameter0.30.61.00.10.81.01.00.70.90.50.90.90.50.90.9
Bone: maximum force0.30.51.10.30.70.81.10.50.50.30.80.80.71.00.7
Bone: maximum moment0.20.30.70.20.50.60.80.30.40.20.60.60.50.80.5
Bone: minimum diameter1.52.73.70.81.71.91.91.51.71.21.81.81.41.91.8
Bone: periosteal estimation1.22.53.50.71.71.81.81.51.61.11.71.81.31.91.7
Bone: periosteal perimeter0.10.20.4-0.40.40.50.60.10.3-0.20.50.60.10.60.4
Bone: post-yield work0.10.20.3-0.4-0.3-0.4-0.0-0.5-0.6-0.6-0.3-0.5-0.2-0.0-0.5
Bone: stiffness0.20.30.80.30.50.60.90.40.40.00.60.70.60.80.5
Bone: tissue strength0.80.71.31.10.80.70.80.90.81.00.80.71.10.80.8
Bone: trabecular number0.30.40.91.00.50.50.60.70.60.80.60.60.80.60.5
Bone: trabecular spacing0.10.20.3-0.10.50.60.40.40.50.30.40.30.20.40.5
Bone: trabecular thickness0.20.20.50.30.60.30.60.10.10.10.70.70.50.70.4
Bone: trabecular tissue density2.12.95.5-2.4-1.5-1.4-1.5-1.9-1.6-2.0-1.6-1.4-2.0-1.6-1.5
Breakpoint value in progressive ratio session0.70.72.1-1.3-0.6-0.7-0.5-1.0-0.9-1.5-0.6-0.6-0.9-0.5-0.7
Distance traveled before self-admin0.10.10.2-0.10.40.20.40.20.20.00.40.30.10.30.3
Distance traveled after self-admin0.40.40.90.90.50.50.50.90.80.90.50.50.60.30.6
Delta time in closed arm before/after self-admin1.51.53.61.90.91.00.91.41.31.50.90.91.30.91.1
Delta time in open arm before/after self-admin1.81.74.2-2.0-0.8-1.2-0.9-1.4-1.3-1.7-0.9-1.1-1.5-1.1-1.2
Diff in mean of infusions in LGA sessions4.45.06.3-1.6-2.4-2.4-2.4-2.1-2.3-1.8-2.4-2.5-2.0-2.2-2.4
Extinction: sum of active levers before priming1.51.52.0-1.0-1.3-1.3-1.3-1.1-1.2-1.4-1.3-1.3-1.1-1.3-1.2
Active lever presses in extinction session 60.10.10.10.10.30.30.30.20.30.20.30.20.10.30.3
Delta distance traveled before/after self-admin0.10.10.20.4-0.4-0.2-0.40.20.10.4-0.3-0.30.0-0.4-0.1
Delta ambulatory time before/after self-admin0.10.10.40.60.10.30.10.60.50.70.10.10.40.00.3
Time in closed arm before self-admin0.20.21.4-1.20.30.10.3-0.4-0.2-0.70.20.3-0.40.30.1
Time in closed arm after self-admin2.42.52.81.31.61.71.61.51.61.41.61.71.51.71.7
Time in open arm before self-admin0.30.31.31.1-0.6-0.2-0.60.20.00.8-0.5-0.50.2-0.5-0.3
Time in open arm after self-admin1.01.11.6-1.2-0.9-1.0-0.9-1.2-1.1-1.2-0.9-0.9-1.1-1.0-1.0
Sum of active levers in priming session hrs 5-61.41.41.71.31.11.11.11.31.31.11.11.11.31.01.3
Time to tail flick, vehicle, before self-admin0.00.00.2-0.4-0.2-0.2-0.2-0.2-0.2-0.1-0.2-0.1-0.3-0.2-0.1
Time to tail flick, vehicle, after self-admin0.10.10.4-0.60.10.10.2-0.3-0.2-0.50.10.2-0.20.10.0
Time to tail flick, test, before self-admin1.91.92.20.91.51.51.41.31.41.21.51.51.31.51.5
Time to tail flick, test, after self-admin4.24.35.7-1.0-2.4-2.3-2.4-1.8-2.0-1.5-2.3-2.3-1.8-2.4-2.2
Delta time to tail flick, vehicle, before/after SA0.40.40.6-0.6-0.6-0.7-0.6-0.7-0.8-0.7-0.6-0.6-0.6-0.7-0.7
Delta time to tail flick, test, before/after SA9.38.310.1-1.9-3.2-3.1-3.1-2.7-2.9-2.4-3.1-3.1-2.7-3.2-3.1
Ambulatory time before self-admin0.00.00.00.10.2-0.00.20.20.10.00.10.10.10.00.0
Ambulatory time after self-admin0.30.30.91.00.10.20.10.80.70.90.10.10.5-0.10.4
Total heroin consumption0.40.51.9-1.2-0.3-0.5-0.3-0.8-0.7-1.4-0.4-0.4-0.7-0.2-0.6
Area under the delay curve0.10.10.40.7-0.0-0.1-0.00.30.20.5-0.0-0.10.3-0.10.1
Delay disc. indifference point, 0s delay0.30.30.60.0-0.6-0.7-0.7-0.4-0.6-0.2-0.7-0.7-0.4-0.7-0.6
Delay disc. indifference point, 16s delay0.00.00.10.3-0.2-0.2-0.20.1-0.00.3-0.2-0.2-0.0-0.3-0.1
Delay disc. indifference point, 2s delay0.60.61.20.0-0.9-1.1-0.9-0.5-0.7-0.2-0.9-1.0-0.5-1.0-0.8
Delay disc. indifference point, 24s delay0.20.20.80.90.10.30.10.60.50.80.10.10.4-0.00.4
Delay disc. indifference point, 4s delay0.10.10.30.3-0.5-0.5-0.5-0.3-0.4-0.1-0.5-0.4-0.1-0.5-0.4
Delay disc. indifference point, 8s delay0.80.91.51.20.80.80.81.11.01.10.80.71.00.70.9
Delay discount exponential model param0.10.10.4-0.70.10.10.1-0.3-0.1-0.50.10.1-0.30.1-0.1
Delay discount hyperbolic model param0.10.10.4-0.60.10.20.1-0.2-0.1-0.40.10.2-0.20.20.0
Fecal boli incidents, locomotor time 10.60.71.10.20.90.91.00.70.80.21.01.10.71.00.9
Change in fecal boli incidents, locomotor task0.30.30.5-0.7-0.5-0.5-0.7-0.6-0.5-0.3-0.5-0.6-0.5-0.5-0.6
Time >=10cm from walls, locomotor time 10.20.21.4-1.2-0.10.00.1-0.6-0.3-0.5-0.10.0-0.8-0.1-0.2
Bouts of movement, locomotor time 10.20.20.8-0.9-0.3-0.0-0.1-0.5-0.3-0.6-0.2-0.1-0.6-0.2-0.2
Total resting periods, locomotor time 10.20.21.1-1.0-0.3-0.1-0.2-0.6-0.4-0.6-0.3-0.1-0.7-0.3-0.3
Rest time, locomotor task time 10.30.30.9-0.9-0.6-0.3-0.3-0.6-0.5-0.9-0.5-0.3-0.7-0.5-0.5
Distance moved, locomotor task time 12.02.23.21.81.51.31.31.61.51.71.41.21.61.41.4
Vertical activity count, locomotor time 10.30.30.50.70.50.40.40.50.50.70.50.40.60.40.5
Time >=10cm from walls, locomotor time 20.50.51.4-1.2-0.5-0.6-0.5-0.9-0.7-0.9-0.5-0.4-0.9-0.5-0.6
Bouts of movement, locomotor time 20.20.20.40.1-0.6-0.3-0.5-0.1-0.20.0-0.6-0.5-0.4-0.6-0.5
Total resting periods, locomotor time 20.20.30.5-0.2-0.7-0.4-0.5-0.3-0.4-0.3-0.6-0.6-0.5-0.7-0.6
Rest time, locomotor task time 20.10.10.3-0.40.20.40.4-0.2-0.0-0.60.20.4-0.10.20.2
Distance moved, locomotor task time 20.30.41.10.80.50.30.20.90.71.00.40.20.70.50.4
Vertical activity count, locomotor time 21.01.11.8-0.3-1.2-1.3-1.4-0.7-0.9-0.5-1.2-1.3-0.7-1.2-1.1
Weight adjusted by age0.10.10.30.5-0.4-0.3-0.40.0-0.10.2-0.3-0.2-0.0-0.4-0.1
Seeking ratio, delayed vs. immediate footshock0.10.10.6-0.30.20.00.2-0.5-0.4-0.80.10.2-0.00.1-0.0
Locomotion in novel chamber1.61.92.5-0.8-1.4-1.4-1.5-1.5-1.6-1.4-1.4-1.5-1.2-1.4-1.6
Locomotion in novel chamber post-restriction0.20.20.60.70.20.50.20.60.50.80.30.10.60.30.4
Progressive ratio0.10.20.40.10.50.60.50.20.40.20.40.40.20.50.3
Food seeking constrained by brief footshock0.30.30.60.6-0.8-0.7-0.8-0.0-0.30.2-0.7-0.8-0.0-0.6-0.6
Seeking ratio, punishment vs. effort0.20.20.60.4-0.7-0.8-0.6-0.0-0.30.2-0.6-0.5-0.1-0.5-0.4
Run reversals in cocaine runway, females0.80.82.20.90.70.80.71.11.11.50.70.60.80.80.8
Run reversals in cocaine runway, males0.40.40.80.90.60.60.60.50.50.40.60.80.70.60.6
Latency to leave start box in cocaine runway0.10.20.30.6-0.5-0.2-0.5-0.1-0.20.1-0.5-0.5-0.1-0.5-0.4
Latency to leave start box in cocaine runway, F0.10.10.30.5-0.5-0.2-0.5-0.1-0.2-0.1-0.5-0.4-0.0-0.5-0.4
Latency to leave start box in cocaine runway, M0.00.00.1-0.2-0.1-0.1-0.1-0.3-0.2-0.1-0.2-0.2-0.3-0.1-0.3
Cd content in liver0.60.70.9-0.8-0.7-0.9-0.8-0.9-0.9-0.9-0.7-0.8-0.7-0.7-0.9
Co content in liver0.00.00.10.30.20.10.10.30.20.30.20.00.30.2-0.0
Cu content in liver2.12.53.71.71.41.61.41.91.91.81.41.31.61.41.6
Fe content in liver0.00.10.3-0.50.20.10.1-0.2-0.1-0.40.20.1-0.00.20.2
K content in liver0.10.10.40.60.00.1-0.00.50.40.60.0-0.10.30.00.1
Mg content in liver0.10.10.20.4-0.2-0.2-0.30.1-0.00.2-0.2-0.30.1-0.2-0.2
Mn content in liver1.82.12.9-0.7-1.7-1.6-1.7-1.2-1.4-0.9-1.7-1.7-1.3-1.7-1.5
Na content in liver0.70.71.00.61.00.91.00.80.80.70.90.80.81.00.8
Rb content in liver0.00.10.1-0.1-0.3-0.0-0.20.10.20.3-0.3-0.3-0.4-0.3-0.2
Se content in liver0.00.10.20.0-0.2-0.3-0.40.0-0.1-0.2-0.3-0.40.0-0.2-0.1
Sr content in liver0.60.61.2-1.1-0.8-0.5-0.7-0.7-0.6-0.8-0.8-0.7-0.9-0.8-0.5
Zn content in liver0.10.20.50.70.20.20.00.60.50.50.20.10.50.20.2