Pgam2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000013532	0.02	0.01	8.7e-03	0.01	0	-0	0	4.0e-02	1.5e-01	5.7e-01	2.5e-01
2	BLA	gene expression	ENSRNOG00000013532	0.08	0.05	3.5e-04	0.04	0.05	0.03	0.03	2.5e-03	1.8e-03	9.3e-03	9.4e-03
3	Brain	gene expression	ENSRNOG00000013532	0.04	0.03	3.8e-04	0.03	0.03	0.03	0.03	8.9e-04	1.0e-03	1.8e-03	8.7e-04
4	Brain	mRNA stability	ENSRNOG00000013532	0.04	0.03	1.4e-04	0.04	0.04	0.04	0.04	9.7e-05	8.7e-05	1.6e-04	1.7e-04
5	Liver	gene expression	ENSRNOG00000013532	0.02	0.02	6.7e-03	0.02	0.01	0.02	0.01	3.1e-03	4.4e-02	6.2e-03	3.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
BMI with tail	0.0	0.0	0.1	0.2	-0.1	-0.1	0.1	0.3
BMI without tail	0.1	0.1	0.3	0.6	0.1	0.1	-0.1	0.5
Body weight	1.2	5.1	6.0	-2.0	-2.4	-2.4	2.3	-2.2
Epididymis fat weight	0.4	0.8	1.1	0.9	0.9	0.9	-0.9	1.0
Glucose	20.1	30.7	34.6	-5.8	-5.0	-5.7	5.3	-5.9
Heart weight	0.1	0.2	0.3	0.4	0.6	0.2	-0.4	0.4
Left kidney weight	0.0	0.1	0.2	0.4	0.3	0.5	-0.4	0.2
Right kidney weight	1.0	2.9	3.5	1.9	1.6	1.7	-1.7	1.7
Tail length	1.1	3.2	3.8	-1.4	-2.0	-1.9	1.9	-1.8
Length with tail	1.8	6.8	7.6	-2.4	-2.7	-2.6	2.5	-2.7
Length without tail	1.3	2.8	3.3	-1.7	-1.6	-1.7	1.5	-1.8
Liver weight, left	2.6	4.2	4.6	2.1	2.0	2.2	-2.1	2.0
Liver weight, right	4.6	7.6	8.2	2.7	2.6	2.8	-2.9	2.7
Parametrial fat weight	1.8	3.6	3.8	-1.9	-2.0	-1.9	1.9	-1.8
Retroperitoneal fat weight	0.0	0.0	0.1	0.3	-0.1	0.2	-0.0	0.3
Intraocular pressure	0.4	0.6	0.8	-0.9	-0.7	-0.7	0.8	-0.8
Extensor digitorum longus weight	3.3	13.1	13.7	-3.5	-3.7	-3.5	3.6	-3.7
Soleus weight	0.5	1.5	1.9	-1.1	-1.3	-1.1	1.2	-1.4
Tibialis anterior weight	1.2	4.0	4.3	-1.8	-2.0	-2.0	2.1	-2.1
Tibia length	0.1	0.4	0.8	0.9	0.4	0.5	-0.6	0.6
Number of licking bursts	3.1	3.6	4.0	-1.9	-1.9	-1.9	1.9	-2.0
Food consumed during 24 hour testing period	2.5	3.0	3.8	-1.7	-1.6	-1.8	1.7	-1.9
Times rat made contact with spout	0.2	0.2	0.4	-0.6	0.0	-0.6	0.3	-0.6
Mean time between licks in bursts	0.6	0.9	1.3	-1.0	-0.7	-1.0	0.8	-1.1
Mean num. licks in bursts	1.6	1.9	2.6	1.3	1.6	1.2	-1.4	1.4
Std. dev. time between licks in bursts	0.0	0.0	0.0	-0.1	-0.1	-0.2	0.1	-0.1
Water consumed over 24 hours	1.9	2.2	2.6	-1.6	-1.3	-1.6	1.4	-1.6
Indifference point 0 sec	1.8	2.9	3.6	-1.5	-1.7	-1.7	1.9	-1.6
Indifference point AUC	0.2	0.2	0.3	-0.4	-0.4	-0.5	0.4	-0.4
Indifference point function ln k	0.0	0.0	0.0	0.0	-0.0	0.0	-0.1	0.1
Indifference point function log k	0.0	0.0	0.0	0.0	-0.0	0.0	-0.1	0.1
Delay discounting total patch changes 0 sec	1.9	3.1	3.9	-1.6	-1.8	-1.8	2.0	-1.6
Delay discounting total patch changes 12 sec	1.2	1.5	1.9	-1.1	-1.2	-1.3	1.4	-1.2
Delay discounting total patch changes 18 sec	2.1	2.7	3.2	-1.5	-1.6	-1.7	1.8	-1.6
Delay discounting total patch changes 24 sec	0.6	0.8	1.2	1.0	0.9	0.8	-0.6	1.1
Delay discounting total patch changes 6 sec	2.3	3.4	4.1	-1.7	-1.9	-1.9	2.0	-1.8
Delay discounting time to switch 0 sec	0.6	0.9	1.1	1.0	0.9	1.1	-1.0	0.9
Delay discounting water rate 0 sec	2.2	3.5	3.9	-1.9	-1.9	-2.0	2.0	-1.7
Delay discounting water rate 12 sec	0.1	0.2	0.3	-0.4	-0.4	-0.6	0.4	-0.3
Delay discounting water rate 18 sec	0.1	0.2	0.3	0.4	0.2	0.6	-0.4	0.5
Delay discounting water rate 24 sec	0.1	0.1	0.1	-0.3	-0.3	-0.3	0.2	-0.4
Delay discounting water rate 6 sec	0.3	0.5	0.5	-0.7	-0.7	-0.7	0.6	-0.7
Locomotor activity	0.5	0.8	1.3	-0.9	-0.8	-0.6	0.9	-1.1
Locomotor testing distance	0.1	0.1	0.3	-0.3	-0.4	-0.1	0.4	-0.5
Locomotor testing rearing	2.0	3.2	3.9	-1.8	-1.7	-1.7	1.8	-2.0
Light reinforcement 1	0.1	0.1	0.2	-0.3	-0.4	-0.4	0.4	-0.3
Light reinforcement 2	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.1	-0.1
Reaction time number correct	0.1	0.1	0.2	-0.5	-0.3	-0.2	0.4	-0.3
Reaction time mean minus median	1.5	2.0	2.5	1.2	1.5	1.6	-1.4	1.2
Reaction time mean minus median AUC	1.3	1.6	2.0	1.1	1.4	1.4	-1.3	1.1
Reaction time num false alarms	0.3	0.4	0.7	-0.4	-0.8	-0.8	0.7	-0.2
Reaction time num false alarms AUC	0.2	0.3	0.5	-0.2	-0.7	-0.7	0.6	-0.0
Reaction time trials correct on left	0.1	0.1	0.2	-0.5	-0.3	-0.2	0.4	-0.3
Reaction time trials on left	0.1	0.1	0.2	-0.4	-0.2	-0.2	0.3	-0.2
Reaction time mean	0.9	1.3	1.6	1.1	1.1	1.3	-1.1	1.1
Reaction time mean AUC	1.5	2.0	2.5	1.4	1.4	1.6	-1.4	1.4
Median of all reaction times	0.5	0.7	0.9	0.9	0.7	0.9	-0.8	0.9
Reaction time omissions	1.4	1.9	2.6	1.4	1.2	1.6	-1.2	1.5
Reaction time false alarm rate	0.1	0.2	0.3	-0.0	-0.6	-0.5	0.4	0.1
Reaction time premature initiation rate	3.0	4.0	4.1	1.9	2.0	2.0	-2.0	2.0
Reaction time premature initiations	1.3	1.9	2.1	1.3	1.4	1.5	-1.4	1.4
Std. dev. reaction times	1.4	1.9	2.4	1.4	1.4	1.5	-1.3	1.3
Reaction time trials completed	0.1	0.1	0.2	-0.4	-0.2	-0.2	0.3	-0.2
Reaction time trials AUC	0.1	0.2	0.3	-0.5	-0.3	-0.3	0.4	-0.4
Social response proportion	2.3	2.4	3.0	-1.7	-1.5	-1.5	1.4	-1.7
Social responses	2.8	3.6	3.8	-1.9	-1.9	-1.7	1.9	-1.9
Social time	0.3	0.4	0.5	-0.5	-0.7	-0.6	0.7	-0.6
Conditioned locomotion	1.1	1.3	1.6	1.2	1.0	1.1	-1.1	1.3
Cocaine response after cond. corrected	1.4	1.6	2.0	-1.3	-1.2	-1.1	1.2	-1.4
Cocaine response after cond. not corrected	1.4	1.5	1.9	-1.2	-1.3	-1.1	1.2	-1.4
Cocaine response before conditioning	0.4	0.5	0.6	0.8	0.6	0.7	-0.7	0.7
Saline control response	0.4	0.5	0.8	0.7	0.7	0.6	-0.6	0.9
Condit. Reinf. active minus inactive responses	0.4	0.5	0.6	0.6	0.7	0.7	-0.7	0.7
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	-0.0	-0.0	0.1	0.0	-0.0
Condit. Reinf. active responses	0.5	0.7	0.9	0.8	0.9	0.9	-0.9	0.9
Condit. Reinf. inactive responses	0.8	1.0	1.1	1.0	1.1	1.0	-1.0	1.0
Condit. Reinf. lever presses	0.4	0.5	0.7	0.7	0.7	0.7	-0.7	0.8
Condit. Reinf. lever reinforcers received	0.4	0.6	0.7	0.7	0.8	0.8	-0.8	0.8
Pavlov. Cond. lever latency	3.2	4.4	4.9	-2.1	-2.2	-2.0	2.0	-2.2
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	-0.2	0.1	-0.0	-0.1	-0.2
Pavlov. Cond. change in total contacts	0.2	0.3	0.4	0.5	0.6	0.6	-0.6	0.3
Pavlov. Cond. index score	1.1	1.4	1.7	1.1	1.3	1.2	-1.2	1.1
Pavlov. Cond. latency score	1.2	1.5	1.7	1.2	1.3	1.2	-1.2	1.2
Pavlov. Cond. lever contacts	2.9	4.1	4.4	2.0	2.1	2.0	-1.9	2.1
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	0.2	-0.1	0.1	-0.0	0.1
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	0.1	-0.1	-0.1	0.1	0.2
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	1.7	1.1	1.3	1.2	-1.2	1.1
Pavlov. Cond. response bias	1.1	1.5	1.8	1.2	1.4	1.2	-1.2	1.2
Conditioned reinforcement - actives	0.0	0.0	0.0	0.1	-0.0	0.1	-0.0	0.0
Conditioned reinforcement - inactives	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.2	-0.3
Conditioned locomotion	0.0	0.0	0.0	0.1	-0.2	-0.1	0.1	0.1
Intermittent access intake day 1-15 change	0.5	0.5	0.6	-0.7	-0.6	-0.7	0.8	-0.6
Intermittent access intake escalation	0.2	0.2	0.3	-0.5	-0.4	-0.5	0.6	-0.3
Intermittent access intake escalation 2	0.2	0.2	0.3	-0.4	-0.3	-0.5	0.5	-0.3
Intermitt. access day 1 inactive lever presses	0.6	0.7	0.9	0.8	0.7	1.0	-0.9	0.6
Intermitt. access day 15 inactive lever presses	1.3	1.4	1.7	-1.1	-1.2	-1.0	1.3	-1.3
Intermitt. access escalation Index	0.2	0.2	0.3	-0.4	-0.4	-0.5	0.6	-0.3
Intermittent access day 1 total infusions	0.3	0.3	0.4	0.6	0.5	0.6	-0.6	0.5
Intermittent access day 15 total infusions	0.1	0.1	0.1	-0.3	-0.3	-0.3	0.4	-0.3
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.3	-0.2
Intermittent access total infusions	0.0	0.0	0.0	-0.0	-0.1	-0.0	0.1	-0.0
Intermittent access day 1 locomotion	1.1	1.2	1.4	1.1	1.0	1.0	-1.2	1.1
Intermittent access day 15 total locomotion	0.1	0.1	0.2	-0.4	-0.5	-0.3	0.4	-0.3
Intermittent access total locomotion	0.1	0.1	0.2	-0.3	-0.5	-0.4	0.3	-0.3
Intermittent access standard deviation	1.2	1.3	1.5	1.1	1.2	1.1	-1.1	1.1
Cocaine induced anxiety	3.5	4.0	4.9	-1.9	-2.0	-2.2	2.0	-1.9
Post-drug Anxiety	1.3	1.4	1.7	-1.2	-1.1	-1.3	1.1	-1.2
Baseline Anxiety	0.2	0.2	0.5	0.3	0.6	0.7	-0.6	0.3
Lifetime Intake	0.0	0.0	0.0	-0.0	-0.1	-0.0	0.1	-0.1
Incentive Sensitization - Responses	0.0	0.0	0.1	-0.2	-0.0	-0.1	0.1	-0.3
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	-0.1	0.0	0.0	0.0	-0.2
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	0.1	0.0	0.1	-0.0	0.0
Progressive ratio test 1 breakpoint	0.2	0.2	0.3	0.5	0.4	0.5	-0.4	0.4
Progressive ratio test 1 inactive lever presses	2.3	2.4	2.8	-1.5	-1.7	-1.4	1.5	-1.7
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	0.0	0.0	0.1	0.0	-0.0
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	-0.1	-0.1	0.0	0.1	-0.1
Progressive ratio test 2 inactive lever presses	0.5	0.6	0.7	-0.7	-0.8	-0.7	0.8	-0.9
Total sessions with >9 infusions	0.0	0.0	0.0	0.2	0.2	0.1	-0.2	0.2
Short access day 1 total inactive lever presses	2.8	3.1	3.7	-1.6	-1.9	-1.8	1.8	-1.6
Short access day 10 total inactive lever presses	0.1	0.2	0.2	0.4	0.3	0.3	-0.4	0.4
Short access day 1 total infusions	0.4	0.4	0.6	0.7	0.6	0.8	-0.7	0.5
Short access day 10 total infusions	0.5	0.5	0.7	0.8	0.7	0.7	-0.7	0.7
Short access total infusions	0.5	0.6	0.7	0.8	0.7	0.8	-0.7	0.7
Short access day 1 locomotion	1.9	2.0	2.2	1.4	1.3	1.5	-1.4	1.4
Short access day 10 total locomotion	0.8	0.9	1.1	1.0	0.9	0.8	-1.1	0.9
Short access total locomotion	4.0	4.1	4.4	2.1	2.0	2.0	-2.1	2.0
Compulsive drug intake	2.3	2.3	2.8	1.7	1.6	1.2	-1.5	1.5
One hour access (0.3 mA shock)	0.0	0.0	0.1	0.3	0.2	0.1	-0.2	0.3
One hour access (shock baseline)	0.4	0.4	0.6	-0.7	-0.7	-0.5	0.7	-0.6
Number of responses in last shaping day	0.1	0.1	0.1	0.4	0.1	0.2	-0.1	0.3
Context. condit. distance diff. score	3.8	4.6	5.1	2.3	2.1	2.1	-2.0	2.2
Locomotion velocity, session 1	0.1	0.1	0.1	-0.3	0.1	-0.2	-0.0	-0.4
Locomotion distance, session 1	0.6	0.8	1.0	0.9	0.8	1.0	-0.9	0.8
Locomotion velocity, session 2	0.1	0.1	0.3	-0.5	-0.1	-0.4	0.2	-0.3
Locomotion distance, session 2	0.9	1.3	1.3	1.1	1.1	1.1	-1.2	1.2
Locomotion velocity, session 3	2.0	2.3	2.9	1.5	1.5	1.3	-1.5	1.7
Locomotion distance, session 3	0.4	0.5	0.9	-0.6	-0.7	-1.0	0.7	-0.3
Stereotopy head waving bouts, day 3	0.8	0.9	1.2	1.0	0.9	1.1	-0.9	1.0
Stereotopy head waving duration, day 3	2.2	2.7	3.2	1.6	1.6	1.8	-1.6	1.6
Locomotion velocity, session 7	0.3	0.3	0.5	-0.6	-0.5	-0.7	0.5	-0.6
Locomotion distance, session 7	0.1	0.1	0.2	0.3	0.4	0.1	-0.4	0.2
Stereotopy head waving bouts, day 7	0.7	0.7	0.9	0.8	0.9	0.9	-0.8	0.8
Stereotopy head waving duration, day 7	0.1	0.1	0.1	0.2	0.3	0.4	-0.3	0.2
Locomotion velocity, session 8	0.8	1.0	1.4	0.8	1.2	0.9	-1.0	1.0
Locomotion distance, session 8	7.2	10.8	11.6	3.4	3.3	3.2	-3.2	3.3
Degree of sensitization distance	2.3	2.3	2.8	1.5	1.7	1.6	-1.6	1.2
Degree of sensitization stereotypy	0.0	0.0	0.0	-0.0	-0.1	-0.0	0.1	-0.1
Condit. Reinf. active minus inactive responses	1.2	1.4	1.7	-1.0	-1.2	-1.2	1.3	-1.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	-0.1	-0.2	-0.2	0.4	-0.3
Condit. Reinf. active responses	0.7	0.8	1.0	-0.8	-0.9	-1.0	0.9	-0.9
Condit. Reinf. inactive responses	0.3	0.4	0.5	-0.6	-0.6	-0.7	0.5	-0.5
Incentive salience index mean	1.6	2.0	2.3	-1.3	-1.5	-1.4	1.5	-1.3
Condit. Reinf. lever presses	0.4	0.5	0.8	-0.7	-0.9	-0.8	0.7	-0.6
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.4	0.2	0.0	-0.2	0.4
Time in novel zone, hab. session 1	0.2	0.2	0.4	-0.6	-0.4	-0.3	0.5	-0.6
Total zone transitions, hab. session 1	0.0	0.1	0.1	-0.3	-0.1	-0.3	0.1	-0.3
Total locomotion distance, hab. session 1	0.1	0.2	0.3	-0.5	-0.4	-0.4	0.2	-0.5
Locomotion velocity, hab. session 1	0.0	0.0	0.1	-0.3	-0.1	-0.2	-0.0	-0.3
Time in familiar zone, hab. session 2	2.1	2.2	2.8	1.7	1.4	1.4	-1.4	1.6
Time in novel zone, hab. session 2	3.2	3.2	3.9	-2.0	-1.6	-1.7	1.7	-1.9
Total zone transitions, hab. session 2	1.0	1.3	1.5	-1.2	-1.1	-1.2	1.0	-1.2
Total locomotion distance, hab. session 2	1.3	1.8	2.0	-1.4	-1.3	-1.4	1.2	-1.4
Locomotion velocity, hab. session 2	1.5	2.0	2.2	-1.5	-1.4	-1.4	1.3	-1.5
Novel to familiar place preference ratio	0.7	0.8	1.1	-1.0	-0.6	-0.9	0.7	-1.1
Novelty place preference	0.8	0.8	1.3	-1.1	-0.7	-0.9	0.7	-1.1
Time in novel zone, NPP test	0.8	0.9	1.3	-1.1	-0.7	-0.9	0.7	-1.2
Total zone transitions, NPP test	0.3	0.4	0.5	0.6	0.5	0.6	-0.7	0.6
Total locomotion distance, NPP test	0.0	0.0	0.1	0.1	0.1	0.1	-0.3	0.1
Locomotion velocity, NPP test	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1	-0.1
Pavlov. Cond. lever latency	0.4	0.6	0.6	-0.8	-0.7	-0.7	0.8	-0.8
Pavlov. Cond. magazine entry latency	1.8	2.3	2.5	1.6	1.5	1.5	-1.5	1.6
Pavlov. Cond. change in total contacts	1.4	1.4	1.7	-1.1	-1.3	-1.3	1.3	-1.0
Pavlov. Cond. index score	1.9	2.5	3.0	1.6	1.5	1.5	-1.5	1.7
Pavlov. Cond. latency score	1.6	2.1	2.4	1.5	1.3	1.4	-1.4	1.6
Pavlov. Cond. lever contacts	0.6	0.7	1.1	0.9	0.7	0.8	-0.8	1.0
Pavlov. Cond. magazine entry number	1.8	2.3	2.8	-1.6	-1.5	-1.4	1.4	-1.7
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.3	-0.4	-0.6	-0.4	0.4	-0.5
Pavlov. Cond. lever-magazine prob. diff.	2.3	2.8	3.4	1.7	1.6	1.6	-1.6	1.8
Pavlov. Cond. response bias	0.7	0.8	1.2	1.0	0.8	0.8	-0.8	1.1
Bone: apparent density	0.1	0.1	0.2	0.4	0.2	0.1	-0.2	0.4
Bone surface	0.3	0.6	0.9	-0.8	-0.6	-0.9	0.7	-0.7
Bone volume	0.3	0.5	0.8	-0.7	-0.6	-0.9	0.7	-0.6
Bone: connectivity density	0.2	0.2	0.3	0.5	0.5	0.4	-0.5	0.6
Bone: cortical apparent density	0.8	1.0	1.2	-0.9	-1.0	-1.0	1.0	-1.1
Bone: cortical area	3.1	4.7	5.4	-2.1	-2.1	-2.3	2.0	-2.2
Bone: cortical porosity	0.0	0.0	0.0	0.0	-0.1	0.0	0.1	-0.0
Bone: cortical porosity	0.2	0.2	0.3	0.6	0.4	0.6	-0.4	0.5
Bone: cortical thickness	2.0	3.2	3.8	-1.8	-1.8	-2.0	1.7	-1.8
Bone: cortical thickness	0.5	0.6	0.7	0.8	0.7	0.8	-0.8	0.7
Bone: cortical tissue density	0.8	1.0	1.3	-0.9	-1.0	-1.1	1.0	-1.1
Bone: elastic displacement	0.9	1.0	1.3	1.1	0.9	1.0	-0.9	1.0
Bone: elastic work	0.0	0.0	0.1	0.3	-0.1	0.1	0.0	0.0
Bone: endosteal estimation	0.0	0.1	0.1	-0.2	-0.3	-0.2	0.3	-0.4
Bone: endosteal perimeter	0.5	1.1	1.3	-1.0	-1.1	-0.9	1.0	-1.2
Bone: final force	0.4	0.6	0.8	-0.6	-0.8	-0.9	0.9	-0.7
Bone: final moment	0.5	0.9	1.1	-0.7	-1.0	-1.0	1.0	-0.8
Bone: marrow area	0.0	0.0	0.1	-0.1	-0.2	-0.1	0.2	-0.3
Bone: maximum diameter	5.2	9.6	10.5	-3.2	-3.0	-3.0	3.0	-3.2
Bone: maximum force	0.3	0.5	0.6	-0.6	-0.7	-0.8	0.7	-0.7
Bone: maximum moment	0.4	0.7	0.9	-0.7	-0.9	-0.9	0.9	-0.9
Bone: minimum diameter	0.0	0.0	0.0	0.1	0.1	-0.0	-0.1	0.1
Bone: periosteal estimation	0.9	1.9	2.2	-1.3	-1.3	-1.4	1.3	-1.5
Bone: periosteal perimeter	1.8	3.0	3.5	-1.7	-1.7	-1.8	1.6	-1.9
Bone: post-yield work	0.2	0.3	0.4	-0.7	-0.5	-0.5	0.5	-0.6
Bone: stiffness	0.0	0.0	0.0	-0.0	0.1	0.0	-0.1	-0.1
Bone: tissue strength	0.0	0.0	0.1	-0.2	0.0	-0.0	0.1	-0.3
Bone: trabecular number	0.0	0.1	0.1	0.3	0.2	0.2	-0.2	0.4
Bone: trabecular spacing	1.1	1.5	2.0	-1.3	-1.1	-1.2	1.1	-1.4
Bone: trabecular thickness	1.3	1.6	2.0	1.4	1.0	1.2	-1.1	1.4
Bone: trabecular tissue density	0.2	0.2	0.3	0.3	0.6	0.5	-0.5	0.3
Breakpoint value in progressive ratio session	1.1	1.3	1.4	-1.2	-1.2	-1.1	1.1	-1.1
Distance traveled before self-admin	0.1	0.1	0.2	-0.4	-0.4	-0.2	0.4	-0.3
Distance traveled after self-admin	0.1	0.1	0.2	-0.2	-0.5	-0.1	0.5	-0.3
Delta time in closed arm before/after self-admin	7.3	7.1	7.6	2.7	2.7	2.6	-2.8	2.6
Delta time in open arm before/after self-admin	8.1	7.7	8.3	-2.8	-2.8	-2.7	2.9	-2.7
Diff in mean of infusions in LGA sessions	0.4	0.5	0.7	0.7	0.5	0.8	-0.6	0.7
Extinction: sum of active levers before priming	0.5	0.5	0.6	-0.7	-0.8	-0.7	0.7	-0.6
Active lever presses in extinction session 6	0.0	0.0	0.0	-0.1	-0.2	-0.1	0.1	-0.1
Delta distance traveled before/after self-admin	0.2	0.3	0.4	0.5	0.4	0.7	-0.5	0.4
Delta ambulatory time before/after self-admin	0.4	0.5	0.6	0.7	0.6	0.8	-0.7	0.6
Time in closed arm before self-admin	0.4	0.4	0.5	-0.6	-0.6	-0.7	0.7	-0.6
Time in closed arm after self-admin	2.1	2.2	2.4	1.5	1.5	1.4	-1.5	1.5
Time in open arm before self-admin	2.6	2.8	3.0	1.6	1.7	1.7	-1.7	1.7
Time in open arm after self-admin	0.1	0.1	0.2	-0.4	-0.4	-0.3	0.4	-0.3
Sum of active levers in priming session hrs 5-6	1.1	1.1	1.2	-1.0	-1.1	-1.1	1.0	-1.0
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.1	0.2	0.1	0.0	-0.2	0.3
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	0.0	-0.2	0.2	0.1	0.1
Time to tail flick, test, before self-admin	0.7	0.7	0.9	0.7	1.0	0.9	-0.8	0.7
Time to tail flick, test, after self-admin	3.2	3.3	3.7	-1.9	-1.9	-1.9	1.7	-1.7
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	0.1	0.1	0.4	-0.1	-0.0
Delta time to tail flick, test, before/after SA	2.8	2.5	3.3	-1.6	-1.7	-1.8	1.5	-1.4
Ambulatory time before self-admin	0.3	0.4	0.5	-0.6	-0.7	-0.4	0.7	-0.6
Ambulatory time after self-admin	0.1	0.2	0.3	-0.3	-0.5	-0.2	0.4	-0.4
Total heroin consumption	0.0	0.0	0.1	-0.2	-0.2	0.1	0.2	-0.1
Area under the delay curve	3.2	3.4	3.8	-1.8	-1.9	-1.8	1.8	-1.9
Delay disc. indifference point, 0s delay	0.8	0.8	1.0	-1.0	-0.9	-0.9	0.8	-1.0
Delay disc. indifference point, 16s delay	2.7	2.7	2.9	-1.6	-1.7	-1.6	1.7	-1.7
Delay disc. indifference point, 2s delay	0.8	0.9	1.2	-1.0	-1.1	-0.8	0.9	-0.9
Delay disc. indifference point, 24s delay	1.7	1.6	1.8	-1.3	-1.3	-1.2	1.3	-1.3
Delay disc. indifference point, 4s delay	2.8	2.9	3.4	-1.7	-1.8	-1.6	1.7	-1.7
Delay disc. indifference point, 8s delay	1.1	1.1	1.3	-1.0	-1.1	-1.0	1.0	-1.1
Delay discount exponential model param	2.9	3.0	3.4	1.7	1.8	1.7	-1.7	1.8
Delay discount hyperbolic model param	3.0	3.2	3.6	1.8	1.9	1.7	-1.7	1.8
Fecal boli incidents, locomotor time 1	0.2	0.2	0.4	0.5	0.5	0.6	-0.5	0.3
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.4	-0.2	-0.2	0.4	-0.4
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	-0.1	0.5	0.3	-0.5	-0.1
Bouts of movement, locomotor time 1	0.6	0.6	0.7	-0.8	-0.7	-0.8	0.8	-0.8
Total resting periods, locomotor time 1	0.2	0.2	0.3	-0.6	-0.4	-0.5	0.5	-0.5
Rest time, locomotor task time 1	0.1	0.1	0.1	-0.4	-0.0	-0.3	0.1	-0.4
Distance moved, locomotor task time 1	0.1	0.2	0.3	-0.3	-0.5	-0.3	0.4	-0.3
Vertical activity count, locomotor time 1	0.0	0.0	0.1	-0.0	-0.2	-0.2	0.2	-0.1
Time >=10cm from walls, locomotor time 2	0.5	0.5	0.8	0.4	0.8	0.8	-0.9	0.4
Bouts of movement, locomotor time 2	0.1	0.1	0.1	0.2	-0.4	0.3	0.2	0.2
Total resting periods, locomotor time 2	0.1	0.1	0.2	0.0	-0.5	0.2	0.4	0.1
Rest time, locomotor task time 2	0.0	0.0	0.1	-0.0	0.1	0.3	-0.0	0.0
Distance moved, locomotor task time 2	0.1	0.1	0.2	0.3	0.4	0.1	-0.4	0.2
Vertical activity count, locomotor time 2	0.1	0.2	0.3	0.3	0.5	-0.1	-0.6	0.3
Weight adjusted by age	0.4	0.5	0.6	-0.7	-0.6	-0.8	0.6	-0.7
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	0.7	0.7	0.5	0.8	-0.7	0.7
Locomotion in novel chamber	5.0	6.2	6.8	2.4	2.6	2.3	-2.6	2.4
Locomotion in novel chamber post-restriction	2.9	3.5	4.0	1.8	2.0	1.8	-2.0	1.8
Progressive ratio	0.2	0.3	0.4	0.6	0.5	0.3	-0.5	0.6
Food seeking constrained by brief footshock	1.6	2.0	2.6	-1.3	-1.5	-1.6	1.3	-1.3
Seeking ratio, punishment vs. effort	1.3	1.6	1.8	-1.3	-1.3	-1.1	1.2	-1.3
Run reversals in cocaine runway, females	0.6	0.6	0.9	0.9	0.6	0.7	-0.7	0.9
Run reversals in cocaine runway, males	0.4	0.4	0.5	-0.7	-0.6	-0.5	0.6	-0.7
Latency to leave start box in cocaine runway	0.0	0.0	0.1	0.1	-0.3	0.0	0.3	0.2
Latency to leave start box in cocaine runway, F	0.4	0.5	0.6	-0.6	-0.8	-0.6	0.7	-0.6
Latency to leave start box in cocaine runway, M	0.9	0.9	1.4	1.1	0.7	0.9	-0.7	1.2
Cd content in liver	0.3	0.3	0.4	0.5	0.5	0.7	-0.5	0.5
Co content in liver	0.0	0.0	0.1	-0.1	-0.3	-0.1	0.4	-0.0
Cu content in liver	0.6	0.8	1.0	-0.9	-0.8	-0.9	0.8	-1.0
Fe content in liver	0.1	0.2	0.2	0.4	0.5	0.2	-0.4	0.4
K content in liver	0.4	0.4	0.6	-0.8	-0.7	-0.6	0.5	-0.6
Mg content in liver	0.5	0.5	0.9	-0.9	-0.7	-0.7	0.6	-0.7
Mn content in liver	0.1	0.1	0.1	-0.3	-0.4	-0.3	0.2	-0.0
Na content in liver	4.4	4.7	5.0	-2.2	-2.1	-2.2	2.1	-2.2
Rb content in liver	2.9	3.7	4.1	-2.0	-1.9	-1.7	1.9	-2.0
Se content in liver	1.7	2.0	2.3	-1.5	-1.5	-1.4	1.4	-1.2
Sr content in liver	2.1	1.9	2.2	-1.4	-1.4	-1.4	1.3	-1.5
Zn content in liver	0.4	0.4	0.7	-0.8	-0.6	-0.5	0.5	-0.8