Hub : Genes

ENSRNOG00000013437

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	ENSRNOG00000013437	0.22	0.14	0.0e+00	0.2	0.2	0.2	0.2	1.4e-21	2.7e-21	1.1e-21	1.7e-21
2	Liver	intron excision ratio	chr3:91668585:91746652	0.08	0.07	1.4e-08	0.06	0.06	0.05	0.05	8.5e-07	7.6e-07	3.6e-06	2.5e-06
3	Liver	intron excision ratio	chr3:91740600:91746652	0.84	0.04	0.0e+00	0.5	0.54	0.53	0.53	4.2e-64	1.5e-70	1.8e-68	2.3e-68
4	Liver	intron excision ratio	chr3:91813900:91833570	0.1	0.09	7.9e-11	0.07	0.07	0.08	0.07	4.3e-08	8.5e-08	7.9e-09	1.6e-08
5	Liver	mRNA stability	ENSRNOG00000013437	0.55	0.23	0.0e+00	0.33	0.33	0.32	0.32	6.4e-38	6.6e-38	5.6e-37	5.8e-37

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
BMI with tail	0.3	1.1	1.3	1.0	1.1	-1.1	-1.1	1.0
BMI without tail	0.2	0.3	0.6	0.4	0.7	-0.5	-0.8	0.3
Body weight	1.0	4.4	4.9	2.1	2.0	-2.1	-2.2	2.1
Epididymis fat weight	1.6	3.7	3.9	1.9	1.9	-2.0	-1.9	1.9
Glucose	1.0	1.5	1.7	1.2	1.3	-1.2	-1.2	1.2
Heart weight	0.4	0.6	0.7	-0.7	-0.8	0.7	0.8	-0.8
Left kidney weight	1.2	3.5	3.9	2.0	1.7	-1.9	-1.8	1.9
Right kidney weight	1.3	3.8	4.5	2.1	1.7	-2.1	-1.9	2.0
Tail length	0.1	0.2	0.4	0.5	0.5	-0.4	-0.7	0.3
Length with tail	0.6	2.3	2.9	1.7	1.3	-1.5	-1.5	1.6
Length without tail	1.5	3.2	4.1	2.0	1.4	-1.9	-1.5	2.0
Liver weight, left	0.7	1.1	1.4	1.0	1.1	-1.0	-1.2	0.9
Liver weight, right	2.3	3.8	4.4	1.9	2.1	-2.0	-2.1	1.6
Parametrial fat weight	0.2	0.4	0.5	0.6	0.5	-0.7	-0.7	0.6
Retroperitoneal fat weight	16.1	53.4	54.2	7.3	7.3	-7.3	-7.4	7.3
Intraocular pressure	0.1	0.2	0.4	-0.2	-0.6	0.4	0.6	-0.1
Extensor digitorum longus weight	0.1	0.4	0.6	-0.5	-0.7	0.5	0.7	-0.6
Soleus weight	0.4	1.2	1.5	-1.0	-1.1	1.1	1.2	-1.1
Tibialis anterior weight	1.4	4.9	5.9	-2.0	-2.3	2.1	2.4	-2.1
Tibia length	0.1	0.3	0.3	-0.6	-0.5	0.5	0.5	-0.6
Number of licking bursts	0.2	0.3	0.4	0.5	0.7	-0.5	-0.5	0.4
Food consumed during 24 hour testing period	3.3	4.0	4.5	1.9	2.1	-2.0	-2.1	1.9
Times rat made contact with spout	0.4	0.5	0.5	0.7	0.6	-0.7	-0.6	0.7
Mean time between licks in bursts	0.3	0.4	0.5	-0.6	-0.5	0.6	0.6	-0.7
Mean num. licks in bursts	0.0	0.0	0.0	0.1	-0.2	-0.0	0.0	0.1
Std. dev. time between licks in bursts	0.7	0.8	1.0	1.0	0.9	-0.9	-0.7	0.9
Water consumed over 24 hours	0.4	0.5	0.6	0.7	0.8	-0.7	-0.6	0.7
Indifference point 0 sec	0.2	0.4	0.7	0.8	0.1	-0.7	-0.2	0.8
Indifference point AUC	0.9	1.0	1.3	-0.9	-1.1	1.0	1.1	-0.8
Indifference point function ln k	0.4	0.6	0.8	0.7	0.9	-0.8	-0.9	0.6
Indifference point function log k	0.4	0.6	0.8	0.7	0.9	-0.8	-0.9	0.6
Delay discounting total patch changes 0 sec	0.3	0.5	1.0	1.0	0.2	-0.8	-0.2	0.9
Delay discounting total patch changes 12 sec	1.6	2.1	3.2	1.7	0.9	-1.6	-1.1	1.8
Delay discounting total patch changes 18 sec	0.1	0.2	0.4	0.6	0.0	-0.4	-0.0	0.7
Delay discounting total patch changes 24 sec	0.2	0.3	0.6	0.8	0.1	-0.6	-0.1	0.7
Delay discounting total patch changes 6 sec	0.2	0.4	0.8	0.8	0.1	-0.6	-0.0	0.9
Delay discounting time to switch 0 sec	0.5	0.8	0.9	0.9	0.9	-0.9	-0.8	0.9
Delay discounting water rate 0 sec	0.0	0.1	0.1	0.3	-0.0	-0.2	-0.1	0.4
Delay discounting water rate 12 sec	0.0	0.0	0.1	-0.0	-0.2	0.2	0.3	-0.1
Delay discounting water rate 18 sec	0.2	0.2	0.5	0.3	0.6	-0.4	-0.7	0.3
Delay discounting water rate 24 sec	0.1	0.1	0.2	0.4	0.3	-0.3	-0.3	0.4
Delay discounting water rate 6 sec	0.0	0.1	0.1	-0.2	-0.3	0.3	0.3	-0.2
Locomotor activity	0.0	0.0	0.0	-0.0	-0.1	-0.0	0.1	-0.1
Locomotor testing distance	1.5	2.4	2.6	1.6	1.6	-1.6	-1.4	1.5
Locomotor testing rearing	0.5	0.8	0.9	0.9	0.9	-0.9	-0.8	0.9
Light reinforcement 1	0.2	0.3	0.4	0.6	0.4	-0.6	-0.4	0.6
Light reinforcement 2	0.7	1.0	1.2	-1.0	-1.0	0.9	0.9	-1.1
Reaction time number correct	0.1	0.1	0.3	-0.2	-0.5	0.3	0.5	-0.3
Reaction time mean minus median	0.0	0.0	0.1	0.1	-0.2	-0.1	0.1	0.0
Reaction time mean minus median AUC	0.0	0.0	0.1	0.2	-0.2	-0.1	0.1	0.1
Reaction time num false alarms	1.4	2.0	2.8	-1.3	-1.7	1.3	1.4	-1.4
Reaction time num false alarms AUC	2.3	3.3	4.4	-1.6	-2.1	1.7	1.8	-1.8
Reaction time trials correct on left	0.1	0.1	0.3	-0.2	-0.5	0.3	0.5	-0.3
Reaction time trials on left	0.1	0.2	0.3	-0.3	-0.6	0.4	0.6	-0.4
Reaction time mean	0.2	0.3	0.4	0.7	0.4	-0.6	-0.5	0.6
Reaction time mean AUC	0.3	0.4	0.5	0.7	0.6	-0.7	-0.6	0.6
Median of all reaction times	0.4	0.6	0.7	0.8	0.7	-0.8	-0.7	0.8
Reaction time omissions	0.1	0.2	0.3	-0.3	-0.6	0.3	0.5	-0.4
Reaction time false alarm rate	1.9	2.8	3.5	-1.6	-1.9	1.6	1.6	-1.7
Reaction time premature initiation rate	0.0	0.1	0.1	-0.4	0.0	0.2	0.1	-0.3
Reaction time premature initiations	0.2	0.2	0.4	-0.6	-0.3	0.4	0.4	-0.6
Std. dev. reaction times	0.0	0.1	0.2	0.4	-0.0	-0.3	-0.1	0.2
Reaction time trials completed	0.1	0.2	0.3	-0.3	-0.6	0.4	0.6	-0.4
Reaction time trials AUC	0.1	0.1	0.2	-0.1	-0.4	0.2	0.4	-0.2
Social response proportion	2.5	2.7	4.5	-1.1	-2.1	1.6	2.0	-1.1
Social responses	0.2	0.3	0.6	0.4	-0.8	0.1	0.7	0.3
Social time	6.1	7.9	9.5	-2.6	-3.1	2.8	3.1	-2.6
Conditioned locomotion	6.6	7.9	9.1	-3.0	-2.6	2.8	2.6	-3.0
Cocaine response after cond. corrected	3.2	3.6	4.3	-1.8	-2.1	1.9	2.0	-1.8
Cocaine response after cond. not corrected	0.8	0.9	1.2	-0.8	-1.0	0.9	1.1	-0.8
Cocaine response before conditioning	5.1	6.2	7.4	2.4	2.7	-2.4	-2.5	2.4
Saline control response	0.0	0.1	0.1	0.2	0.3	-0.2	-0.3	0.1
Condit. Reinf. active minus inactive responses	2.3	2.9	3.0	1.7	1.7	-1.7	-1.7	1.6
Condit. Reinf. active-inactive response ratio	5.3	5.5	5.9	2.2	2.4	-2.4	-2.4	2.2
Condit. Reinf. active responses	1.6	2.2	2.4	1.5	1.5	-1.6	-1.5	1.5
Condit. Reinf. inactive responses	0.0	0.0	0.0	0.2	0.0	-0.1	-0.0	0.1
Condit. Reinf. lever presses	2.1	3.0	3.5	1.9	1.5	-1.8	-1.6	1.8
Condit. Reinf. lever reinforcers received	1.7	2.4	2.5	1.6	1.5	-1.6	-1.5	1.5
Pavlov. Cond. lever latency	2.0	2.8	3.1	-1.8	-1.7	1.6	1.6	-1.7
Pavlov. Cond. magazine entry latency	1.0	1.1	1.4	1.0	1.2	-1.0	-1.1	1.0
Pavlov. Cond. change in total contacts	0.4	0.6	0.7	0.8	0.7	-0.7	-0.7	0.8
Pavlov. Cond. index score	1.9	2.5	2.8	1.7	1.6	-1.6	-1.5	1.6
Pavlov. Cond. latency score	1.8	2.3	2.5	1.6	1.5	-1.5	-1.5	1.5
Pavlov. Cond. lever contacts	2.9	4.0	4.5	2.1	1.9	-2.0	-1.9	2.0
Pavlov. Cond. magazine entry number	1.0	1.3	1.4	-1.2	-1.1	1.1	1.1	-1.1
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	0.3	0.2	-0.3	-0.2	0.3
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.3	2.6	1.6	1.5	-1.5	-1.5	1.5
Pavlov. Cond. response bias	2.9	4.0	4.5	2.1	2.0	-2.0	-1.9	2.0
Conditioned reinforcement - actives	5.5	5.4	7.3	2.0	2.7	-2.1	-2.7	2.0
Conditioned reinforcement - inactives	13.7	15.5	17.3	3.7	4.2	-3.9	-4.2	3.8
Conditioned locomotion	5.5	6.6	6.9	2.6	2.5	-2.6	-2.6	2.5
Intermittent access intake day 1-15 change	0.6	0.6	0.9	0.5	0.9	-0.7	-0.9	0.5
Intermittent access intake escalation	0.9	0.9	1.1	0.9	1.0	-1.0	-1.0	0.9
Intermittent access intake escalation 2	1.0	1.0	1.2	0.9	1.1	-1.0	-1.0	0.9
Intermitt. access day 1 inactive lever presses	2.3	2.5	3.3	1.3	1.8	-1.6	-1.8	1.3
Intermitt. access day 15 inactive lever presses	2.8	3.1	4.7	1.4	2.2	-1.6	-2.2	1.3
Intermitt. access escalation Index	0.7	0.6	1.1	-1.0	-0.6	0.8	0.6	-0.9
Intermittent access day 1 total infusions	2.0	2.2	3.6	1.3	1.8	-1.3	-1.9	1.1
Intermittent access day 15 total infusions	4.0	4.5	5.9	2.0	2.3	-2.0	-2.4	1.9
Intermittent access terminal intake (last 3 days)	4.5	4.9	6.2	2.1	2.3	-2.2	-2.5	2.0
Intermittent access total infusions	4.1	4.6	5.6	2.0	2.3	-2.0	-2.4	1.9
Intermittent access day 1 locomotion	2.3	2.3	3.0	1.5	1.6	-1.4	-1.7	1.4
Intermittent access day 15 total locomotion	1.0	1.1	1.3	1.1	1.1	-1.1	-1.1	0.9
Intermittent access total locomotion	2.3	2.6	3.6	1.5	1.8	-1.5	-1.9	1.3
Intermittent access standard deviation	2.0	2.1	2.8	1.4	1.7	-1.4	-1.7	1.1
Cocaine induced anxiety	2.3	2.7	3.1	1.5	1.7	-1.6	-1.7	1.6
Post-drug Anxiety	0.4	0.4	0.7	0.5	0.7	-0.6	-0.8	0.5
Baseline Anxiety	3.3	3.5	5.3	-1.4	-2.3	1.7	2.2	-1.5
Lifetime Intake	4.3	4.8	5.5	2.1	2.3	-2.1	-2.3	2.1
Incentive Sensitization - Responses	0.6	0.6	1.3	0.2	1.1	-0.5	-1.1	0.3
Incentive Sensitization - Breakpoint	0.5	0.5	1.2	0.2	1.1	-0.4	-1.0	0.3
Progressive ratio test 1 active lever presses	2.1	2.2	2.8	1.4	1.6	-1.3	-1.7	1.4
Progressive ratio test 1 breakpoint	2.0	2.0	2.6	1.3	1.5	-1.2	-1.6	1.3
Progressive ratio test 1 inactive lever presses	2.3	2.5	3.7	1.3	1.9	-1.4	-1.9	1.3
Progressive ratio test 2 active lever presses	2.5	2.7	3.8	1.4	1.9	-1.5	-1.9	1.4
Progressive ratio test 2 breakpoint	3.0	3.3	4.7	1.5	2.2	-1.6	-2.1	1.6
Progressive ratio test 2 inactive lever presses	6.8	7.9	9.1	2.7	3.0	-2.7	-3.0	2.7
Total sessions with >9 infusions	3.0	3.3	3.8	1.9	1.7	-1.8	-1.8	2.0
Short access day 1 total inactive lever presses	1.4	1.6	2.0	1.4	1.1	-1.3	-1.3	1.2
Short access day 10 total inactive lever presses	0.5	0.5	0.7	0.7	0.7	-0.8	-0.9	0.6
Short access day 1 total infusions	7.0	7.4	8.2	2.8	2.6	-2.7	-2.6	2.9
Short access day 10 total infusions	2.3	2.5	3.1	1.7	1.4	-1.5	-1.6	1.6
Short access total infusions	2.8	3.1	3.3	1.8	1.7	-1.7	-1.8	1.8
Short access day 1 locomotion	0.9	0.9	1.3	1.1	0.8	-1.0	-0.8	1.1
Short access day 10 total locomotion	0.8	0.8	1.8	0.3	1.4	-0.6	-1.3	0.1
Short access total locomotion	1.2	1.2	1.5	1.1	1.1	-1.1	-1.2	1.0
Compulsive drug intake	3.2	3.1	3.8	-1.9	-1.6	1.8	1.7	-1.9
One hour access (0.3 mA shock)	2.8	3.3	4.3	1.6	2.1	-1.7	-2.0	1.6
One hour access (shock baseline)	6.1	7.1	7.4	2.7	2.7	-2.5	-2.7	2.7
Number of responses in last shaping day	2.0	2.1	2.3	1.5	1.5	-1.3	-1.3	1.5
Context. condit. distance diff. score	4.2	5.2	5.4	2.3	2.3	-2.3	-2.3	2.2
Locomotion velocity, session 1	1.3	1.4	1.8	-1.0	-1.4	1.1	1.3	-1.1
Locomotion distance, session 1	0.1	0.2	0.2	-0.4	-0.5	0.4	0.4	-0.4
Locomotion velocity, session 2	0.0	0.0	0.0	0.1	0.0	-0.2	-0.2	0.1
Locomotion distance, session 2	0.0	0.0	0.0	-0.0	-0.1	0.1	0.1	-0.0
Locomotion velocity, session 3	0.2	0.2	0.3	0.5	0.4	-0.4	-0.3	0.5
Locomotion distance, session 3	0.1	0.1	0.1	0.3	0.3	-0.2	-0.2	0.2
Stereotopy head waving bouts, day 3	0.2	0.2	0.3	-0.5	-0.4	0.5	0.4	-0.5
Stereotopy head waving duration, day 3	0.2	0.2	0.3	0.4	0.5	-0.4	-0.5	0.4
Locomotion velocity, session 7	0.1	0.2	0.2	0.5	0.3	-0.4	-0.3	0.5
Locomotion distance, session 7	0.1	0.1	0.2	-0.3	-0.4	0.3	0.4	-0.4
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	-0.2	0.0	0.2	0.0	-0.1
Stereotopy head waving duration, day 7	0.0	0.1	0.1	-0.3	-0.2	0.3	0.2	-0.2
Locomotion velocity, session 8	0.3	0.4	0.5	0.6	0.5	-0.7	-0.6	0.6
Locomotion distance, session 8	2.5	3.8	4.0	2.0	2.0	-1.9	-1.9	1.9
Degree of sensitization distance	0.3	0.3	0.4	-0.5	-0.6	0.5	0.5	-0.5
Degree of sensitization stereotypy	0.2	0.3	0.4	-0.5	-0.5	0.6	0.5	-0.5
Condit. Reinf. active minus inactive responses	2.1	2.3	2.7	1.5	1.7	-1.5	-1.5	1.4
Condit. Reinf. active-inactive response ratio	6.3	6.8	7.5	2.6	2.7	-2.6	-2.6	2.6
Condit. Reinf. active responses	0.2	0.3	0.4	0.5	0.6	-0.5	-0.5	0.4
Condit. Reinf. inactive responses	2.3	2.7	2.9	-1.6	-1.7	1.6	1.7	-1.6
Incentive salience index mean	1.1	1.3	1.8	1.0	1.3	-1.1	-1.2	1.0
Condit. Reinf. lever presses	0.2	0.3	0.5	0.4	0.7	-0.4	-0.6	0.3
Time in familiar zone, hab. session 1	0.8	0.8	1.1	-0.7	-1.0	0.8	1.0	-0.7
Time in novel zone, hab. session 1	1.8	1.7	2.0	1.2	1.4	-1.3	-1.4	1.2
Total zone transitions, hab. session 1	1.9	2.7	2.9	1.7	1.6	-1.6	-1.6	1.7
Total locomotion distance, hab. session 1	0.3	0.4	0.6	0.6	0.8	-0.6	-0.7	0.6
Locomotion velocity, hab. session 1	0.2	0.3	0.4	0.5	0.6	-0.5	-0.6	0.4
Time in familiar zone, hab. session 2	0.3	0.3	0.4	-0.6	-0.5	0.6	0.5	-0.6
Time in novel zone, hab. session 2	0.3	0.3	0.5	0.7	0.5	-0.6	-0.5	0.7
Total zone transitions, hab. session 2	0.3	0.4	0.5	0.6	0.7	-0.6	-0.7	0.5
Total locomotion distance, hab. session 2	0.5	0.7	0.8	-0.8	-0.8	0.9	0.8	-0.9
Locomotion velocity, hab. session 2	0.4	0.5	0.6	-0.8	-0.7	0.8	0.7	-0.8
Novel to familiar place preference ratio	3.5	3.6	3.7	1.9	1.9	-1.9	-1.9	1.9
Novelty place preference	3.6	3.8	4.0	1.9	2.0	-2.0	-2.0	1.9
Time in novel zone, NPP test	3.0	3.1	3.3	1.8	1.8	-1.8	-1.8	1.7
Total zone transitions, NPP test	2.0	2.8	3.0	-1.7	-1.6	1.7	1.6	-1.7
Total locomotion distance, NPP test	2.6	3.6	3.9	-1.9	-1.8	2.0	1.8	-1.9
Locomotion velocity, NPP test	2.2	3.2	3.5	-1.8	-1.7	1.9	1.7	-1.9
Pavlov. Cond. lever latency	0.1	0.1	0.3	-0.1	-0.5	0.1	0.4	-0.1
Pavlov. Cond. magazine entry latency	0.8	1.1	1.4	1.0	1.2	-1.0	-1.1	1.0
Pavlov. Cond. change in total contacts	0.1	0.2	0.2	-0.4	-0.2	0.4	0.3	-0.5
Pavlov. Cond. index score	0.0	0.0	0.1	0.1	0.4	-0.1	-0.2	0.1
Pavlov. Cond. latency score	0.1	0.1	0.2	0.2	0.4	-0.1	-0.3	0.2
Pavlov. Cond. lever contacts	0.0	0.0	0.1	0.0	0.4	-0.0	-0.3	0.0
Pavlov. Cond. magazine entry number	0.9	1.1	1.5	-1.0	-1.2	1.0	1.1	-1.0
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	0.3	0.3	-0.4	-0.3	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.1	0.2	0.2	-0.1	-0.2
Pavlov. Cond. response bias	0.2	0.3	0.5	0.4	0.7	-0.4	-0.6	0.4
Bone: apparent density	0.6	1.0	1.3	1.2	1.0	-1.0	-0.8	1.1
Bone surface	0.3	0.6	1.0	1.0	0.8	-0.7	-0.6	0.8
Bone volume	1.0	1.7	2.3	1.5	1.2	-1.3	-1.0	1.4
Bone: connectivity density	0.5	0.8	1.0	1.0	1.0	-0.8	-0.7	1.0
Bone: cortical apparent density	0.0	0.0	0.0	-0.1	0.0	0.1	0.0	-0.1
Bone: cortical area	0.7	1.0	1.2	1.1	0.9	-1.1	-1.0	0.9
Bone: cortical porosity	0.6	0.6	0.8	-0.8	-0.9	0.8	0.8	-0.8
Bone: cortical porosity	0.1	0.1	0.2	-0.4	-0.4	0.3	0.3	-0.4
Bone: cortical thickness	0.0	0.0	0.1	0.2	0.2	-0.2	-0.2	0.1
Bone: cortical thickness	1.3	1.6	1.7	-1.2	-1.2	1.3	1.3	-1.3
Bone: cortical tissue density	0.0	0.0	0.0	-0.1	0.1	0.0	-0.0	-0.1
Bone: elastic displacement	0.7	0.8	0.8	-0.9	-0.9	0.9	0.9	-0.9
Bone: elastic work	0.0	0.0	0.0	0.1	-0.0	-0.1	0.0	0.0
Bone: endosteal estimation	0.0	0.0	0.1	-0.0	-0.2	0.0	0.1	-0.2
Bone: endosteal perimeter	0.3	0.7	0.8	0.9	0.7	-0.9	-0.8	0.8
Bone: final force	0.3	0.5	0.7	0.8	0.5	-0.8	-0.6	0.7
Bone: final moment	0.1	0.2	0.4	0.6	0.3	-0.6	-0.3	0.5
Bone: marrow area	0.0	0.0	0.1	-0.0	-0.2	0.0	0.2	-0.2
Bone: maximum diameter	0.3	0.6	0.7	0.8	0.7	-0.8	-0.8	0.7
Bone: maximum force	0.7	1.2	1.4	1.2	0.9	-1.2	-1.0	1.1
Bone: maximum moment	0.3	0.6	0.8	0.9	0.5	-0.9	-0.7	0.8
Bone: minimum diameter	1.5	2.8	3.3	1.8	1.6	-1.8	-1.7	1.6
Bone: periosteal estimation	0.1	0.2	0.3	0.5	0.3	-0.5	-0.3	0.4
Bone: periosteal perimeter	0.7	1.1	1.3	1.1	1.0	-1.1	-1.1	1.0
Bone: post-yield work	0.0	0.0	0.0	0.1	-0.1	-0.0	0.0	0.1
Bone: stiffness	1.3	2.1	2.4	1.5	1.2	-1.6	-1.3	1.5
Bone: tissue strength	0.5	0.5	0.5	-0.7	-0.7	0.6	0.7	-0.6
Bone: trabecular number	0.6	1.0	1.3	1.1	1.0	-0.9	-0.7	1.1
Bone: trabecular spacing	0.0	0.0	0.1	-0.1	0.1	-0.1	-0.3	0.0
Bone: trabecular thickness	0.3	0.4	0.6	0.8	0.5	-0.7	-0.4	0.7
Bone: trabecular tissue density	0.8	1.2	1.4	-1.2	-1.0	1.1	0.9	-1.2
Breakpoint value in progressive ratio session	2.6	2.9	4.1	-2.0	-1.3	1.8	1.3	-2.0
Distance traveled before self-admin	0.1	0.1	0.2	-0.4	0.4	0.1	-0.4	-0.2
Distance traveled after self-admin	0.7	0.8	1.0	0.6	1.0	-0.8	-0.9	0.9
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	0.1	0.0	-0.2	-0.0	0.1
Delta time in open arm before/after self-admin	1.0	1.0	1.4	-0.7	-1.2	1.0	1.2	-0.7
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	0.2	0.1	-0.1	-0.1	0.1
Extinction: sum of active levers before priming	0.3	0.3	0.6	-0.7	-0.0	0.5	0.0	-0.8
Active lever presses in extinction session 6	0.3	0.2	0.5	0.2	0.7	-0.4	-0.7	0.1
Delta distance traveled before/after self-admin	0.0	0.0	0.1	0.3	0.1	-0.2	-0.1	0.3
Delta ambulatory time before/after self-admin	0.3	0.3	0.4	0.6	0.5	-0.6	-0.4	0.6
Time in closed arm before self-admin	2.7	3.0	4.2	1.5	2.1	-1.6	-1.9	1.6
Time in closed arm after self-admin	2.8	3.0	3.4	1.6	1.8	-1.8	-1.8	1.6
Time in open arm before self-admin	3.2	3.4	3.7	-1.9	-1.9	1.8	1.8	-1.9
Time in open arm after self-admin	7.1	7.8	8.4	-2.8	-2.9	2.9	2.7	-2.7
Sum of active levers in priming session hrs 5-6	2.8	2.7	3.8	-1.9	-1.3	1.7	1.2	-2.0
Time to tail flick, vehicle, before self-admin	0.5	0.5	0.6	0.7	0.6	-0.7	-0.6	0.7
Time to tail flick, vehicle, after self-admin	3.3	3.6	4.3	1.8	2.0	-1.8	-2.1	1.8
Time to tail flick, test, before self-admin	0.1	0.1	0.2	-0.2	0.5	0.0	-0.4	0.0
Time to tail flick, test, after self-admin	0.9	0.9	1.2	0.8	1.0	-0.9	-1.1	1.0
Delta time to tail flick, vehicle, before/after SA	1.3	1.3	1.7	1.1	1.2	-1.1	-1.3	0.9
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	0.1	-0.3	-0.0	0.1	0.1
Ambulatory time before self-admin	0.1	0.1	0.2	-0.3	0.4	-0.0	-0.3	0.0
Ambulatory time after self-admin	0.6	0.7	1.5	0.4	1.2	-0.7	-1.0	0.7
Total heroin consumption	1.3	1.6	2.6	-1.6	-0.8	1.3	0.7	-1.6
Area under the delay curve	0.1	0.1	0.3	-0.2	-0.5	0.4	0.4	-0.2
Delay disc. indifference point, 0s delay	0.3	0.3	0.6	0.8	0.2	-0.6	-0.3	0.7
Delay disc. indifference point, 16s delay	0.3	0.3	0.6	-0.3	-0.8	0.6	0.7	-0.4
Delay disc. indifference point, 2s delay	0.3	0.3	0.4	0.6	0.4	-0.6	-0.5	0.6
Delay disc. indifference point, 24s delay	0.4	0.4	0.5	-0.5	-0.7	0.6	0.6	-0.6
Delay disc. indifference point, 4s delay	0.2	0.3	0.3	-0.4	-0.6	0.5	0.4	-0.5
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	0.2	-0.0	-0.1	-0.2	0.2
Delay discount exponential model param	0.2	0.2	0.4	0.3	0.6	-0.5	-0.5	0.4
Delay discount hyperbolic model param	0.1	0.1	0.2	0.1	0.5	-0.3	-0.3	0.2
Fecal boli incidents, locomotor time 1	7.0	7.6	8.2	-2.7	-2.8	2.7	2.9	-2.7
Change in fecal boli incidents, locomotor task	2.2	2.1	2.5	1.6	1.4	-1.4	-1.4	1.4
Time >=10cm from walls, locomotor time 1	1.3	1.3	1.5	-1.1	-1.1	1.2	1.2	-1.1
Bouts of movement, locomotor time 1	0.6	0.6	0.9	-0.9	-0.3	0.9	0.6	-0.9
Total resting periods, locomotor time 1	1.0	1.1	1.5	-1.2	-0.6	1.2	0.9	-1.1
Rest time, locomotor task time 1	2.7	2.9	3.3	-1.6	-1.7	1.7	1.8	-1.7
Distance moved, locomotor task time 1	2.4	2.6	2.8	1.5	1.7	-1.6	-1.7	1.5
Vertical activity count, locomotor time 1	0.6	0.6	0.7	0.8	0.8	-0.8	-0.8	0.7
Time >=10cm from walls, locomotor time 2	2.3	2.4	2.7	1.5	1.7	-1.5	-1.6	1.5
Bouts of movement, locomotor time 2	1.6	1.7	2.0	1.3	1.4	-1.3	-1.3	1.3
Total resting periods, locomotor time 2	1.4	1.5	1.9	1.2	1.4	-1.2	-1.2	1.2
Rest time, locomotor task time 2	4.3	5.0	5.5	-2.3	-2.1	2.3	2.1	-2.4
Distance moved, locomotor task time 2	2.6	3.1	3.3	1.7	1.8	-1.8	-1.7	1.8
Vertical activity count, locomotor time 2	4.1	4.5	5.0	2.2	2.0	-2.2	-2.0	2.2
Weight adjusted by age	0.0	0.0	0.0	0.1	-0.0	-0.0	-0.2	-0.0
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	0.9	0.9	0.5	-0.7	-0.5	0.7
Locomotion in novel chamber	0.6	0.7	0.9	1.0	0.7	-0.9	-0.8	0.7
Locomotion in novel chamber post-restriction	1.7	2.0	2.4	-1.3	-1.4	1.3	1.6	-1.5
Progressive ratio	0.1	0.1	0.3	-0.0	0.5	0.1	-0.5	-0.1
Food seeking constrained by brief footshock	0.1	0.1	0.3	0.3	0.5	-0.2	-0.3	0.4
Seeking ratio, punishment vs. effort	0.1	0.1	0.4	0.1	-0.5	0.0	0.6	0.2
Run reversals in cocaine runway, females	1.0	0.9	1.6	0.7	1.3	-0.8	-1.2	0.8
Run reversals in cocaine runway, males	0.2	0.2	0.3	-0.5	-0.2	0.5	0.5	-0.4
Latency to leave start box in cocaine runway	1.3	1.4	2.2	-1.4	-0.8	1.2	0.8	-1.5
Latency to leave start box in cocaine runway, F	1.3	1.4	1.9	-1.3	-0.9	1.3	0.9	-1.4
Latency to leave start box in cocaine runway, M	0.2	0.2	0.4	-0.6	-0.1	0.4	0.1	-0.6
Cd content in liver	0.3	0.4	0.5	0.7	0.5	-0.6	-0.4	0.7
Co content in liver	2.2	2.6	2.9	-1.7	-1.4	1.7	1.5	-1.7
Cu content in liver	1.5	1.8	2.1	-1.5	-1.2	1.3	1.2	-1.4
Fe content in liver	0.1	0.1	0.2	-0.2	-0.4	0.3	0.4	-0.2
K content in liver	0.7	0.7	0.8	-0.9	-0.8	0.8	0.8	-0.9
Mg content in liver	0.7	0.7	0.7	-0.8	-0.8	0.8	0.8	-0.8
Mn content in liver	1.7	2.0	2.2	-1.5	-1.3	1.4	1.4	-1.5
Na content in liver	0.1	0.1	0.1	-0.1	0.4	0.0	-0.4	-0.1
Rb content in liver	0.7	0.9	1.3	-0.8	-1.1	0.9	1.1	-0.8
Se content in liver	4.4	5.3	6.2	-2.4	-2.2	2.3	2.1	-2.5
Sr content in liver	0.0	0.0	0.0	-0.2	0.1	0.1	-0.0	-0.2
Zn content in liver	1.8	2.0	2.2	-1.5	-1.3	1.4	1.4	-1.5