Hub : Genes

Aspg

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression ENSRNOG00000012843 0.03 0.03 4.8e-03 0.02 0.01 0.01 0.02 3.7e-03 1.4e-02 6.2e-02 9.1e-03
2 Eye gene expression ENSRNOG00000012843 0.89 0.08 2.5e-07 0.21 0.14 0.19 0.12 3.5e-04 3.4e-03 8.1e-04 6.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
BMI with tail2.27.27.7-2.62.8
BMI without tail0.40.91.7-0.41.3
Body weight0.21.01.71.3-0.6
Epididymis fat weight4.19.510.3-3.03.2
Glucose0.81.21.60.9-1.2
Heart weight0.00.00.00.10.2
Left kidney weight0.82.43.31.8-1.2
Right kidney weight0.41.31.91.4-0.8
Tail length3.711.213.93.7-2.9
Length with tail5.018.221.24.6-3.9
Length without tail2.24.75.12.1-2.3
Liver weight, left2.94.75.02.2-2.1
Liver weight, right0.00.00.00.10.0
Parametrial fat weight0.00.00.0-0.20.1
Retroperitoneal fat weight0.20.70.9-0.90.7
Intraocular pressure0.10.20.3-0.50.3
Extensor digitorum longus weight6.024.025.75.1-4.7
Soleus weight0.00.00.00.20.2
Tibialis anterior weight0.31.11.31.1-0.9
Tibia length0.30.81.00.8-1.0
Number of licking bursts0.00.00.00.1-0.2
Food consumed during 24 hour testing period0.10.20.30.5-0.3
Times rat made contact with spout0.40.40.50.6-0.7
Mean time between licks in bursts0.60.91.4-0.61.2
Mean num. licks in bursts0.00.00.00.2-0.2
Std. dev. time between licks in bursts0.50.60.9-0.50.9
Water consumed over 24 hours3.64.34.42.1-2.1
Indifference point 0 sec3.65.86.42.5-2.3
Indifference point AUC2.42.83.11.6-1.8
Indifference point function ln k0.50.81.01.0-0.7
Indifference point function log k0.50.81.01.0-0.7
Delay discounting total patch changes 0 sec4.06.57.32.7-2.4
Delay discounting total patch changes 12 sec3.44.54.82.0-2.2
Delay discounting total patch changes 18 sec1.62.12.71.2-1.7
Delay discounting total patch changes 24 sec0.20.30.30.5-0.5
Delay discounting total patch changes 6 sec2.43.74.62.1-1.7
Delay discounting time to switch 0 sec11.717.919.1-4.44.1
Delay discounting water rate 0 sec19.731.333.85.8-5.4
Delay discounting water rate 12 sec10.916.419.94.5-3.6
Delay discounting water rate 18 sec4.76.36.92.6-2.4
Delay discounting water rate 24 sec4.05.56.42.5-2.1
Delay discounting water rate 6 sec5.37.89.03.0-2.6
Locomotor activity0.10.10.10.3-0.4
Locomotor testing distance0.30.50.50.7-0.7
Locomotor testing rearing1.32.02.0-1.41.4
Light reinforcement 10.00.00.0-0.00.1
Light reinforcement 21.72.22.3-1.51.5
Reaction time number correct3.04.34.42.1-2.1
Reaction time mean minus median0.30.30.5-0.70.4
Reaction time mean minus median AUC0.20.30.3-0.60.4
Reaction time num false alarms1.21.62.11.5-1.0
Reaction time num false alarms AUC1.72.32.91.7-1.3
Reaction time trials correct on left3.04.34.42.1-2.1
Reaction time trials on left3.04.24.32.0-2.1
Reaction time mean0.91.31.5-1.21.0
Reaction time mean AUC0.60.81.0-1.00.8
Median of all reaction times0.40.60.6-0.80.7
Reaction time omissions0.60.81.20.7-1.1
Reaction time false alarm rate0.20.20.40.6-0.2
Reaction time premature initiation rate1.01.41.41.2-1.1
Reaction time premature initiations2.94.14.12.0-2.0
Std. dev. reaction times0.50.81.0-1.00.7
Reaction time trials completed3.04.24.32.0-2.1
Reaction time trials AUC3.24.64.72.2-2.1
Social response proportion0.70.71.11.1-0.6
Social responses0.00.00.10.00.2
Social time1.21.62.11.4-1.0
Conditioned locomotion1.41.61.71.2-1.3
Cocaine response after cond. corrected0.60.60.7-0.70.8
Cocaine response after cond. not corrected1.82.12.2-1.41.5
Cocaine response before conditioning2.22.72.7-1.61.7
Saline control response0.20.30.3-0.40.6
Condit. Reinf. active minus inactive responses0.50.70.90.9-0.7
Condit. Reinf. active-inactive response ratio0.70.71.01.0-0.7
Condit. Reinf. active responses0.00.10.10.30.0
Condit. Reinf. inactive responses0.50.60.7-0.70.9
Condit. Reinf. lever presses1.21.62.2-1.01.5
Condit. Reinf. lever reinforcers received0.10.10.20.40.1
Pavlov. Cond. lever latency1.72.43.11.3-1.8
Pavlov. Cond. magazine entry latency4.55.15.9-2.12.4
Pavlov. Cond. change in total contacts3.54.95.6-2.12.4
Pavlov. Cond. index score4.25.56.8-2.12.6
Pavlov. Cond. latency score4.25.36.3-2.12.5
Pavlov. Cond. lever contacts2.43.44.4-1.52.1
Pavlov. Cond. magazine entry number3.24.04.81.8-2.2
Pavlov. Cond. intertrial magazine entries5.97.67.72.8-2.8
Pavlov. Cond. lever-magazine prob. diff.4.65.97.3-2.12.7
Pavlov. Cond. response bias3.14.35.7-1.72.4
Conditioned reinforcement - actives2.42.43.01.7-1.3
Conditioned reinforcement - inactives0.40.50.70.9-0.5
Conditioned locomotion0.40.50.8-0.50.9
Intermittent access intake day 1-15 change1.51.51.6-1.31.2
Intermittent access intake escalation1.61.51.6-1.21.2
Intermittent access intake escalation 20.20.20.2-0.50.3
Intermitt. access day 1 inactive lever presses2.22.43.01.7-1.4
Intermitt. access day 15 inactive lever presses0.80.81.31.1-0.6
Intermitt. access escalation Index0.20.20.20.5-0.4
Intermittent access day 1 total infusions0.30.30.6-0.20.8
Intermittent access day 15 total infusions1.71.92.5-1.21.6
Intermittent access terminal intake (last 3 days)2.02.22.9-1.31.7
Intermittent access total infusions0.70.81.3-0.51.2
Intermittent access day 1 locomotion0.70.71.2-0.51.1
Intermittent access day 15 total locomotion0.10.20.3-0.10.5
Intermittent access total locomotion0.30.30.5-0.30.7
Intermittent access standard deviation3.13.33.9-1.72.0
Cocaine induced anxiety2.73.13.21.8-1.7
Post-drug Anxiety2.42.72.81.7-1.6
Baseline Anxiety1.41.41.6-1.31.1
Lifetime Intake0.30.40.7-0.10.8
Incentive Sensitization - Responses0.00.00.10.10.3
Incentive Sensitization - Breakpoint0.00.00.10.20.1
Progressive ratio test 1 active lever presses0.00.00.00.10.2
Progressive ratio test 1 breakpoint0.10.10.1-0.10.4
Progressive ratio test 1 inactive lever presses2.52.73.01.7-1.5
Progressive ratio test 2 active lever presses0.10.10.10.30.2
Progressive ratio test 2 breakpoint0.10.10.10.40.2
Progressive ratio test 2 inactive lever presses0.80.91.41.2-0.7
Total sessions with >9 infusions0.10.10.10.20.2
Short access day 1 total inactive lever presses0.10.10.10.30.4
Short access day 10 total inactive lever presses0.30.30.40.6-0.4
Short access day 1 total infusions0.50.60.91.0-0.5
Short access day 10 total infusions0.40.40.8-0.10.9
Short access total infusions0.20.20.40.10.6
Short access day 1 locomotion0.50.50.9-0.31.0
Short access day 10 total locomotion0.60.70.9-0.61.0
Short access total locomotion0.10.10.10.10.3
Compulsive drug intake0.10.10.1-0.30.3
One hour access (0.3 mA shock)0.20.20.40.70.1
One hour access (shock baseline)0.10.10.10.30.3
Number of responses in last shaping day0.30.30.3-0.50.5
Context. condit. distance diff. score2.32.83.21.8-1.6
Locomotion velocity, session 10.20.20.20.4-0.5
Locomotion distance, session 10.40.50.7-0.90.6
Locomotion velocity, session 20.00.00.10.3-0.1
Locomotion distance, session 20.30.40.4-0.60.6
Locomotion velocity, session 30.10.10.1-0.40.2
Locomotion distance, session 30.00.00.00.0-0.2
Stereotopy head waving bouts, day 30.10.20.20.4-0.4
Stereotopy head waving duration, day 30.30.40.40.6-0.5
Locomotion velocity, session 70.30.30.5-0.70.4
Locomotion distance, session 70.81.01.0-1.01.0
Stereotopy head waving bouts, day 70.91.01.11.0-1.1
Stereotopy head waving duration, day 70.30.40.50.6-0.7
Locomotion velocity, session 80.30.40.50.7-0.6
Locomotion distance, session 80.00.00.00.20.1
Degree of sensitization distance0.20.20.2-0.50.3
Degree of sensitization stereotypy0.10.10.20.2-0.5
Condit. Reinf. active minus inactive responses0.50.50.6-0.70.8
Condit. Reinf. active-inactive response ratio2.72.92.9-1.71.7
Condit. Reinf. active responses0.10.10.2-0.20.4
Condit. Reinf. inactive responses2.22.62.81.7-1.5
Incentive salience index mean0.50.60.6-0.80.7
Condit. Reinf. lever presses0.10.10.2-0.40.3
Time in familiar zone, hab. session 10.40.30.3-0.60.6
Time in novel zone, hab. session 10.20.10.2-0.40.3
Total zone transitions, hab. session 10.50.70.8-0.70.9
Total locomotion distance, hab. session 10.10.10.30.5-0.1
Locomotion velocity, hab. session 10.60.91.31.1-0.7
Time in familiar zone, hab. session 20.40.40.5-0.60.7
Time in novel zone, hab. session 20.00.00.0-0.10.2
Total zone transitions, hab. session 20.70.91.0-1.00.9
Total locomotion distance, hab. session 20.30.50.50.6-0.7
Locomotion velocity, hab. session 20.50.70.80.8-0.9
Novel to familiar place preference ratio0.60.60.9-0.90.6
Novelty place preference0.40.40.5-0.70.5
Time in novel zone, NPP test0.30.30.4-0.70.4
Total zone transitions, NPP test0.10.10.1-0.30.4
Total locomotion distance, NPP test0.00.00.00.2-0.1
Locomotion velocity, NPP test0.10.10.10.3-0.2
Pavlov. Cond. lever latency0.81.01.01.0-1.0
Pavlov. Cond. magazine entry latency0.81.01.5-1.20.8
Pavlov. Cond. change in total contacts0.30.30.4-0.60.5
Pavlov. Cond. index score1.31.72.0-1.41.2
Pavlov. Cond. latency score0.91.11.4-1.20.9
Pavlov. Cond. lever contacts1.11.31.5-1.21.0
Pavlov. Cond. magazine entry number1.31.61.71.3-1.2
Pavlov. Cond. intertrial magazine entries6.37.68.22.9-2.6
Pavlov. Cond. lever-magazine prob. diff.1.01.31.6-1.31.0
Pavlov. Cond. response bias1.41.71.8-1.31.3
Bone: apparent density0.10.10.1-0.40.2
Bone surface0.10.10.2-0.40.3
Bone volume0.00.10.1-0.20.3
Bone: connectivity density0.00.00.10.1-0.3
Bone: cortical apparent density8.711.412.13.3-3.5
Bone: cortical area0.81.31.31.1-1.1
Bone: cortical porosity0.00.00.00.0-0.1
Bone: cortical porosity0.20.20.2-0.50.5
Bone: cortical thickness0.71.21.41.0-1.2
Bone: cortical thickness0.70.80.80.9-0.9
Bone: cortical tissue density8.911.612.33.3-3.5
Bone: elastic displacement0.40.50.50.7-0.7
Bone: elastic work0.10.10.10.3-0.2
Bone: endosteal estimation0.20.40.6-0.40.7
Bone: endosteal perimeter0.00.10.10.30.2
Bone: final force0.30.40.50.7-0.6
Bone: final moment0.30.50.60.8-0.6
Bone: marrow area0.10.30.5-0.40.7
Bone: maximum diameter0.00.00.00.2-0.2
Bone: maximum force0.20.40.50.7-0.6
Bone: maximum moment0.20.40.40.6-0.5
Bone: minimum diameter0.91.72.21.5-1.1
Bone: periosteal estimation0.10.20.30.5-0.3
Bone: periosteal perimeter0.10.10.30.5-0.1
Bone: post-yield work1.11.61.61.2-1.3
Bone: stiffness1.52.42.71.6-1.5
Bone: tissue strength0.00.00.1-0.1-0.2
Bone: trabecular number0.00.00.10.1-0.3
Bone: trabecular spacing0.00.10.1-0.10.3
Bone: trabecular thickness0.10.10.10.3-0.4
Bone: trabecular tissue density0.20.30.50.4-0.7
Breakpoint value in progressive ratio session0.00.00.0-0.00.1
Distance traveled before self-admin0.00.00.1-0.10.2
Distance traveled after self-admin0.40.50.50.7-0.6
Delta time in closed arm before/after self-admin0.00.00.10.10.3
Delta time in open arm before/after self-admin0.40.40.50.6-0.7
Diff in mean of infusions in LGA sessions0.00.00.10.0-0.2
Extinction: sum of active levers before priming0.00.00.00.2-0.1
Active lever presses in extinction session 61.91.82.41.6-1.1
Delta distance traveled before/after self-admin0.00.00.00.0-0.2
Delta ambulatory time before/after self-admin0.50.50.60.7-0.8
Time in closed arm before self-admin4.04.65.1-2.32.0
Time in closed arm after self-admin2.32.42.4-1.51.6
Time in open arm before self-admin6.97.49.23.0-2.4
Time in open arm after self-admin4.34.75.62.4-2.0
Sum of active levers in priming session hrs 5-60.10.10.1-0.10.3
Time to tail flick, vehicle, before self-admin0.50.50.50.7-0.7
Time to tail flick, vehicle, after self-admin0.20.30.3-0.50.6
Time to tail flick, test, before self-admin0.10.10.10.3-0.3
Time to tail flick, test, after self-admin1.41.42.01.0-1.4
Delta time to tail flick, vehicle, before/after SA0.10.10.1-0.30.3
Delta time to tail flick, test, before/after SA0.70.70.80.7-0.9
Ambulatory time before self-admin0.10.10.2-0.40.4
Ambulatory time after self-admin0.00.00.0-0.10.2
Total heroin consumption1.21.51.61.3-1.2
Area under the delay curve0.10.10.1-0.30.4
Delay disc. indifference point, 0s delay0.10.10.10.3-0.3
Delay disc. indifference point, 16s delay0.00.00.0-0.10.1
Delay disc. indifference point, 2s delay0.30.30.5-0.70.4
Delay disc. indifference point, 24s delay0.20.20.4-0.60.3
Delay disc. indifference point, 4s delay0.10.10.10.3-0.3
Delay disc. indifference point, 8s delay0.20.20.3-0.20.5
Delay discount exponential model param0.10.10.10.2-0.3
Delay discount hyperbolic model param0.10.10.10.4-0.3
Fecal boli incidents, locomotor time 12.72.94.0-2.01.3
Change in fecal boli incidents, locomotor task2.01.93.71.9-0.3
Time >=10cm from walls, locomotor time 10.30.30.6-0.10.8
Bouts of movement, locomotor time 12.62.94.6-2.11.1
Total resting periods, locomotor time 12.42.74.1-2.01.1
Rest time, locomotor task time 10.10.10.3-0.0-0.5
Distance moved, locomotor task time 10.20.20.4-0.10.6
Vertical activity count, locomotor time 10.50.50.60.6-0.8
Time >=10cm from walls, locomotor time 20.30.30.50.4-0.7
Bouts of movement, locomotor time 21.51.61.91.2-1.4
Total resting periods, locomotor time 21.21.21.31.1-1.2
Rest time, locomotor task time 20.30.30.50.7-0.4
Distance moved, locomotor task time 20.30.30.5-0.70.4
Vertical activity count, locomotor time 20.30.30.70.0-0.8
Weight adjusted by age0.00.00.00.10.1
Seeking ratio, delayed vs. immediate footshock0.30.30.50.4-0.7
Locomotion in novel chamber5.56.88.02.8-2.4
Locomotion in novel chamber post-restriction0.00.00.10.00.3
Progressive ratio0.91.11.61.3-0.8
Food seeking constrained by brief footshock1.11.42.30.7-1.5
Seeking ratio, punishment vs. effort0.10.20.3-0.5-0.2
Run reversals in cocaine runway, females2.02.03.0-1.71.0
Run reversals in cocaine runway, males0.70.71.10.6-1.1
Latency to leave start box in cocaine runway0.00.00.1-0.10.3
Latency to leave start box in cocaine runway, F0.10.20.3-0.50.2
Latency to leave start box in cocaine runway, M0.10.10.1-0.00.3
Cd content in liver0.50.61.01.0-0.4
Co content in liver1.11.31.51.2-1.1
Cu content in liver0.91.11.2-1.11.0
Fe content in liver0.20.30.5-0.70.3
K content in liver0.20.20.30.4-0.5
Mg content in liver0.40.40.50.7-0.5
Mn content in liver0.20.20.40.6-0.2
Na content in liver0.10.10.2-0.50.1
Rb content in liver0.91.21.21.1-1.0
Se content in liver0.10.10.2-0.30.4
Sr content in liver0.30.20.40.6-0.3
Zn content in liver0.20.30.40.6-0.4