Mlf1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000012827	0.03	0.02	3.4e-03	0	0.01	0	0	1.3e-01	1.8e-02	3.0e-01	9.5e-02
2	BLA	gene expression	ENSRNOG00000012827	0.09	0.05	4.8e-04	0.04	0.05	0.01	0.03	2.0e-03	1.6e-03	1.2e-01	7.1e-03
3	Brain	gene expression	ENSRNOG00000012827	0.03	0.02	9.0e-03	0.01	0.01	0	0.01	2.6e-02	3.4e-02	1.6e-01	6.6e-02
4	IL	gene expression	ENSRNOG00000012827	0.38	0.15	4.4e-06	0.11	0.13	0.12	0.12	1.3e-03	4.8e-04	8.1e-04	8.3e-04
5	PL	gene expression	ENSRNOG00000012827	0.11	0.05	1.8e-08	0.08	0.07	0.05	0.07	1.3e-06	4.7e-06	7.0e-05	4.8e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
BMI with tail	0.4	1.4	5.4	-0.6	0.2	-2.3	0.8	0.7
BMI without tail	0.2	0.5	0.7	0.8	-0.9	-0.1	-0.7	-0.7
Body weight	0.3	1.4	4.4	-1.0	0.2	-2.1	0.9	0.9
Epididymis fat weight	1.0	2.3	3.9	2.0	-1.2	1.2	-1.6	-1.5
Glucose	0.2	0.3	0.5	0.7	-0.5	-0.4	-0.4	-0.6
Heart weight	0.1	0.1	0.2	0.3	-0.1	-0.5	-0.2	-0.1
Left kidney weight	0.5	1.4	1.8	0.9	-1.2	1.2	-1.2	-1.3
Right kidney weight	0.1	0.3	1.0	0.3	-0.4	1.0	-0.5	-0.5
Tail length	0.3	0.8	1.0	0.8	-1.0	0.8	-1.0	-0.9
Length with tail	0.1	0.5	1.5	-1.2	0.0	-0.7	0.5	0.6
Length without tail	0.9	2.0	3.8	-1.9	0.6	-1.6	1.3	1.3
Liver weight, left	0.1	0.1	0.2	-0.2	0.2	-0.4	0.3	0.2
Liver weight, right	0.5	0.9	1.8	-1.0	0.2	-1.3	0.8	1.0
Parametrial fat weight	0.2	0.4	0.6	0.8	-0.7	0.1	-0.8	-0.5
Retroperitoneal fat weight	0.0	0.1	0.3	0.5	0.0	-0.5	0.1	0.0
Intraocular pressure	0.1	0.2	0.4	-0.0	0.6	0.6	0.2	0.2
Extensor digitorum longus weight	3.7	14.8	17.6	-4.2	2.9	-4.1	4.0	3.8
Soleus weight	0.5	1.5	2.2	0.7	-1.5	0.8	-1.4	-1.5
Tibialis anterior weight	0.3	1.0	1.5	1.0	-0.7	1.1	-1.0	-1.2
Tibia length	0.3	0.8	1.4	-1.2	0.9	-0.2	0.9	0.9
Number of licking bursts	1.2	1.4	3.9	0.4	-2.0	-0.5	-1.3	-1.1
Food consumed during 24 hour testing period	0.3	0.3	0.9	0.6	0.5	1.0	-0.1	-0.4
Times rat made contact with spout	3.0	3.5	4.5	2.0	-1.4	1.8	-1.9	-2.1
Mean time between licks in bursts	6.9	9.6	11.3	-2.9	3.0	-2.9	3.3	3.4
Mean num. licks in bursts	0.7	0.8	2.4	0.8	1.1	1.5	0.2	-0.2
Std. dev. time between licks in bursts	5.2	6.2	10.1	-2.3	1.7	-3.2	2.5	2.5
Water consumed over 24 hours	2.1	2.4	3.9	1.2	-2.0	0.5	-1.7	-1.9
Indifference point 0 sec	1.3	2.1	3.2	1.1	-1.5	1.2	-1.5	-1.8
Indifference point AUC	0.8	1.0	1.4	-1.1	1.2	-0.3	1.2	1.0
Indifference point function ln k	0.3	0.4	0.5	0.5	-0.6	0.5	-0.7	-0.7
Indifference point function log k	0.3	0.4	0.5	0.5	-0.6	0.5	-0.7	-0.7
Delay discounting total patch changes 0 sec	1.1	1.7	2.6	1.0	-1.3	1.2	-1.3	-1.6
Delay discounting total patch changes 12 sec	0.6	0.8	1.0	1.0	-0.7	1.0	-0.9	-0.9
Delay discounting total patch changes 18 sec	0.6	0.8	1.5	0.7	-0.9	0.7	-0.8	-1.2
Delay discounting total patch changes 24 sec	0.6	0.7	1.3	0.4	-1.0	0.8	-0.8	-1.1
Delay discounting total patch changes 6 sec	0.1	0.2	0.5	-0.0	-0.5	0.3	-0.3	-0.7
Delay discounting time to switch 0 sec	0.9	1.3	2.7	1.6	-1.1	0.4	-1.3	-1.0
Delay discounting water rate 0 sec	0.5	0.7	1.1	-1.0	1.0	-0.5	1.0	0.6
Delay discounting water rate 12 sec	0.7	1.1	2.0	0.7	-1.4	0.4	-1.2	-1.1
Delay discounting water rate 18 sec	0.3	0.3	0.8	-0.9	0.5	-0.4	0.7	0.2
Delay discounting water rate 24 sec	0.6	0.8	1.5	0.6	-1.0	0.6	-1.0	-1.2
Delay discounting water rate 6 sec	0.5	0.7	2.0	-0.1	-1.4	-0.6	-0.8	-0.7
Locomotor activity	0.3	0.5	0.8	-0.9	0.5	-0.9	0.8	0.5
Locomotor testing distance	0.7	1.2	1.7	-1.2	0.8	-1.3	1.2	1.0
Locomotor testing rearing	0.2	0.3	1.0	-0.2	-1.0	-0.6	-0.4	-0.3
Light reinforcement 1	0.2	0.4	0.7	-0.2	0.8	-0.4	0.8	0.5
Light reinforcement 2	2.0	2.7	5.6	-1.1	2.4	-0.4	1.9	1.7
Reaction time number correct	3.9	5.7	7.5	2.1	-2.6	1.9	-2.7	-2.5
Reaction time mean minus median	3.0	4.0	5.9	-1.6	1.4	-2.4	1.9	2.4
Reaction time mean minus median AUC	6.4	8.2	11.8	-2.3	2.3	-3.2	2.9	3.4
Reaction time num false alarms	1.5	2.1	4.8	0.7	-2.2	-0.3	-1.5	-1.7
Reaction time num false alarms AUC	1.6	2.2	5.2	0.8	-2.3	-0.3	-1.6	-1.6
Reaction time trials correct on left	3.9	5.7	7.5	2.1	-2.6	1.9	-2.7	-2.5
Reaction time trials on left	3.8	5.3	7.1	2.1	-2.6	1.7	-2.7	-2.4
Reaction time mean	2.4	3.3	4.8	-1.6	1.4	-2.2	1.8	2.0
Reaction time mean AUC	3.8	5.1	6.3	-2.1	1.8	-2.5	2.3	2.5
Median of all reaction times	1.6	2.2	3.2	-1.3	1.2	-1.8	1.4	1.6
Reaction time omissions	4.7	6.3	8.6	-1.8	2.2	-2.9	2.5	2.9
Reaction time false alarm rate	0.3	0.5	1.4	-0.2	-0.8	-1.2	-0.2	-0.3
Reaction time premature initiation rate	0.7	0.9	1.9	0.7	-1.4	0.6	-1.2	-0.8
Reaction time premature initiations	2.9	4.1	6.6	1.6	-2.6	1.3	-2.4	-1.9
Std. dev. reaction times	3.9	5.4	9.0	-2.2	1.2	-3.0	2.1	2.6
Reaction time trials completed	3.8	5.3	7.1	2.1	-2.6	1.7	-2.7	-2.4
Reaction time trials AUC	3.6	5.1	6.8	2.0	-2.5	1.7	-2.6	-2.3
Social response proportion	0.3	0.3	0.9	-0.9	0.2	-0.2	0.5	0.4
Social responses	0.6	0.8	2.1	0.2	-1.5	0.2	-1.0	-0.9
Social time	0.0	0.0	0.1	0.0	-0.0	0.3	-0.0	-0.1
Conditioned locomotion	0.1	0.1	0.4	-0.4	-0.3	-0.6	0.1	0.2
Cocaine response after cond. corrected	0.3	0.4	1.1	0.6	1.1	0.4	0.4	0.3
Cocaine response after cond. not corrected	0.5	0.6	1.5	-0.1	1.2	-0.3	0.9	0.8
Cocaine response before conditioning	0.2	0.3	0.6	-0.3	-0.8	-0.7	-0.2	-0.4
Saline control response	0.5	0.7	1.7	-0.6	-1.1	-1.3	-0.2	-0.3
Condit. Reinf. active minus inactive responses	0.1	0.1	0.5	-0.2	-0.3	-0.7	0.1	-0.0
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.8	0.9	-0.2	0.3	-0.4	-0.7
Condit. Reinf. active responses	0.4	0.5	1.2	-0.9	-0.4	-1.1	0.3	0.5
Condit. Reinf. inactive responses	0.6	0.8	1.7	-1.3	-0.2	-1.1	0.4	0.8
Condit. Reinf. lever presses	2.7	3.7	4.5	-1.9	1.5	-1.9	2.0	2.1
Condit. Reinf. lever reinforcers received	0.3	0.4	0.8	-0.9	-0.4	-0.9	0.3	0.4
Pavlov. Cond. lever latency	1.7	2.4	2.8	1.5	-1.2	1.6	-1.6	-1.7
Pavlov. Cond. magazine entry latency	0.6	0.7	2.2	-0.1	-1.5	-0.5	-0.8	-0.6
Pavlov. Cond. change in total contacts	1.1	1.6	2.6	-1.2	0.7	-1.6	1.2	1.4
Pavlov. Cond. index score	0.9	1.2	2.3	-1.3	0.2	-1.5	0.8	1.0
Pavlov. Cond. latency score	0.8	1.0	2.1	-1.2	0.0	-1.5	0.7	0.9
Pavlov. Cond. lever contacts	1.2	1.7	2.3	-1.2	1.2	-1.1	1.4	1.5
Pavlov. Cond. magazine entry number	0.3	0.3	1.0	0.0	1.0	0.4	0.5	0.4
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.7	-0.1	0.8	0.3	0.5	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.6	-1.1	0.2	-1.3	0.8	0.9
Pavlov. Cond. response bias	0.9	1.2	1.7	-1.2	0.6	-1.3	1.0	1.2
Conditioned reinforcement - actives	0.1	0.1	0.3	0.1	0.5	0.3	0.2	-0.1
Conditioned reinforcement - inactives	1.2	1.4	1.8	-1.0	1.3	-1.0	1.3	1.2
Conditioned locomotion	0.4	0.5	1.5	0.2	-0.2	0.8	-0.3	-1.2
Intermittent access intake day 1-15 change	0.2	0.2	0.3	-0.0	0.5	-0.6	0.4	0.5
Intermittent access intake escalation	0.6	0.5	0.8	-0.4	0.9	-0.8	0.7	0.9
Intermittent access intake escalation 2	0.0	0.0	0.1	0.3	0.3	-0.0	0.1	0.1
Intermitt. access day 1 inactive lever presses	2.2	2.3	4.1	-1.2	2.0	-0.7	1.8	1.6
Intermitt. access day 15 inactive lever presses	3.4	3.8	6.0	-1.7	2.4	-0.9	2.2	2.1
Intermitt. access escalation Index	2.0	1.8	2.5	-1.6	1.4	-0.3	1.4	1.6
Intermittent access day 1 total infusions	0.4	0.5	0.7	-0.4	0.8	-0.8	0.8	0.5
Intermittent access day 15 total infusions	1.0	1.2	2.0	-0.7	1.4	-0.9	1.2	1.0
Intermittent access terminal intake (last 3 days)	0.9	1.0	1.5	-0.8	1.2	-0.8	1.2	0.9
Intermittent access total infusions	1.0	1.1	1.5	-0.9	1.2	-0.8	1.2	1.0
Intermittent access day 1 locomotion	0.2	0.2	0.6	-0.1	0.8	-0.3	0.6	0.2
Intermittent access day 15 total locomotion	0.0	0.0	0.1	0.3	0.2	-0.2	0.1	-0.2
Intermittent access total locomotion	0.2	0.2	0.4	-0.2	0.6	-0.4	0.5	0.1
Intermittent access standard deviation	1.8	1.9	3.5	1.9	-0.2	1.7	-1.1	-1.3
Cocaine induced anxiety	2.3	2.7	3.5	1.6	-1.3	1.7	-1.7	-1.9
Post-drug Anxiety	0.1	0.1	0.3	0.3	0.5	0.5	0.1	-0.1
Baseline Anxiety	6.5	6.8	8.0	-2.6	2.4	-2.4	2.8	2.8
Lifetime Intake	0.5	0.5	0.7	-0.7	0.8	-0.7	0.8	0.7
Incentive Sensitization - Responses	1.3	1.3	4.0	-0.5	0.6	-2.0	0.9	1.2
Incentive Sensitization - Breakpoint	1.2	1.2	3.5	-0.4	0.6	-1.9	0.9	1.1
Progressive ratio test 1 active lever presses	0.2	0.2	0.3	-0.5	0.4	-0.5	0.5	0.3
Progressive ratio test 1 breakpoint	0.3	0.3	0.3	-0.5	0.5	-0.6	0.6	0.4
Progressive ratio test 1 inactive lever presses	1.7	1.8	2.8	-1.2	1.7	-0.9	1.6	1.2
Progressive ratio test 2 active lever presses	0.7	0.7	2.1	-0.2	0.7	-1.4	0.7	0.7
Progressive ratio test 2 breakpoint	0.7	0.8	2.6	-0.1	0.5	-1.6	0.6	0.8
Progressive ratio test 2 inactive lever presses	0.2	0.2	0.6	-0.3	0.8	0.0	0.6	0.0
Total sessions with >9 infusions	0.3	0.3	0.5	-0.4	0.7	-0.6	0.6	0.3
Short access day 1 total inactive lever presses	0.7	0.8	1.4	-1.2	1.0	-0.2	1.1	0.3
Short access day 10 total inactive lever presses	0.0	0.0	0.1	-0.1	0.2	-0.3	0.2	0.2
Short access day 1 total infusions	0.3	0.3	1.0	-0.2	1.0	0.3	0.6	0.2
Short access day 10 total infusions	0.7	0.8	1.3	-1.1	0.8	-0.7	0.9	0.8
Short access total infusions	0.5	0.5	0.7	-0.8	0.5	-0.8	0.7	0.7
Short access day 1 locomotion	0.1	0.2	0.4	0.2	-0.4	0.1	-0.4	-0.7
Short access day 10 total locomotion	1.4	1.6	2.0	1.4	-0.7	1.4	-1.2	-1.4
Short access total locomotion	0.0	0.0	0.1	0.2	-0.2	-0.0	-0.2	-0.3
Compulsive drug intake	0.7	0.7	2.4	0.3	-1.5	-0.5	-0.9	-0.2
One hour access (0.3 mA shock)	0.1	0.1	0.1	-0.1	0.4	-0.4	0.3	0.3
One hour access (shock baseline)	0.4	0.4	1.5	-0.1	1.2	0.2	0.7	0.2
Number of responses in last shaping day	0.3	0.3	0.9	1.0	0.4	0.6	-0.2	-0.3
Context. condit. distance diff. score	4.8	5.8	7.1	2.4	-2.3	2.1	-2.6	-2.7
Locomotion velocity, session 1	0.1	0.1	0.2	0.2	0.2	0.5	0.0	-0.1
Locomotion distance, session 1	1.2	1.6	2.4	-1.6	1.1	-0.8	1.4	1.3
Locomotion velocity, session 2	0.1	0.1	0.2	-0.5	-0.4	-0.2	-0.1	0.1
Locomotion distance, session 2	2.8	4.0	5.5	-2.4	1.7	-1.6	2.1	2.1
Locomotion velocity, session 3	0.4	0.4	0.9	-0.5	-0.9	-1.0	-0.2	-0.2
Locomotion distance, session 3	2.1	2.2	3.9	1.1	-2.0	0.4	-1.7	-1.7
Stereotopy head waving bouts, day 3	0.7	0.9	1.9	0.5	-1.4	0.4	-1.1	-0.9
Stereotopy head waving duration, day 3	0.8	0.9	2.3	0.4	-1.5	0.2	-1.1	-1.0
Locomotion velocity, session 7	0.8	0.8	1.5	-0.9	1.2	-0.1	1.0	0.9
Locomotion distance, session 7	0.5	0.6	1.9	0.8	0.5	1.4	-0.2	-0.4
Stereotopy head waving bouts, day 7	0.4	0.5	1.1	-1.1	-0.1	-0.8	0.4	0.6
Stereotopy head waving duration, day 7	1.7	2.1	3.9	-1.8	0.2	-2.0	1.1	1.3
Locomotion velocity, session 8	0.2	0.3	0.5	-0.6	0.2	-0.7	0.5	0.5
Locomotion distance, session 8	0.2	0.2	0.4	-0.7	0.5	-0.1	0.5	0.4
Degree of sensitization distance	2.1	2.1	5.7	-0.4	2.4	0.7	1.5	1.4
Degree of sensitization stereotypy	1.1	1.2	2.0	-1.4	0.6	-1.0	1.0	1.2
Condit. Reinf. active minus inactive responses	3.5	3.9	4.6	-2.0	1.7	-1.9	2.1	2.1
Condit. Reinf. active-inactive response ratio	4.1	4.4	5.3	-2.3	1.7	-2.0	2.2	2.3
Condit. Reinf. active responses	5.0	6.1	7.1	-2.4	2.2	-2.5	2.7	2.6
Condit. Reinf. inactive responses	0.6	0.7	1.3	-0.3	1.1	-0.6	1.0	0.8
Incentive salience index mean	3.2	3.9	4.8	-1.9	2.0	-1.4	2.2	2.2
Condit. Reinf. lever presses	1.7	2.3	3.7	-1.3	1.9	-0.4	1.8	1.7
Time in familiar zone, hab. session 1	2.2	2.0	2.3	1.5	-1.2	1.3	-1.5	-1.5
Time in novel zone, hab. session 1	0.3	0.3	0.8	-0.6	-0.0	-0.9	0.3	0.4
Total zone transitions, hab. session 1	1.7	2.4	2.8	-1.6	1.4	-1.5	1.7	1.5
Total locomotion distance, hab. session 1	1.9	2.8	3.8	-1.6	1.9	-0.9	1.9	1.7
Locomotion velocity, hab. session 1	3.1	4.5	6.5	-2.0	2.6	-0.9	2.4	2.2
Time in familiar zone, hab. session 2	8.2	8.5	10.4	2.6	-2.9	2.7	-3.2	-3.1
Time in novel zone, hab. session 2	3.9	4.0	5.7	-1.9	1.5	-2.4	2.0	2.0
Total zone transitions, hab. session 2	1.6	2.1	2.8	-1.7	1.3	-1.1	1.6	1.6
Total locomotion distance, hab. session 2	2.0	2.7	3.9	-1.4	2.0	-0.9	1.9	1.8
Locomotion velocity, hab. session 2	2.7	3.6	5.2	-1.7	2.3	-0.9	2.2	2.0
Novel to familiar place preference ratio	1.7	1.7	2.8	-1.7	0.8	-1.2	1.2	1.5
Novelty place preference	1.4	1.4	2.6	-1.6	0.6	-1.1	1.1	1.4
Time in novel zone, NPP test	1.1	1.1	2.3	-1.5	0.3	-1.1	0.8	1.1
Total zone transitions, NPP test	2.4	3.5	4.5	-2.0	2.0	-0.9	2.1	2.0
Total locomotion distance, NPP test	2.4	3.4	4.6	-2.0	2.1	-0.6	2.1	2.0
Locomotion velocity, NPP test	2.9	4.1	6.0	-2.1	2.5	-0.5	2.3	2.2
Pavlov. Cond. lever latency	0.4	0.5	0.7	0.8	-0.7	0.4	-0.8	-0.8
Pavlov. Cond. magazine entry latency	0.2	0.2	0.3	0.4	-0.5	0.3	-0.5	-0.6
Pavlov. Cond. change in total contacts	0.6	0.7	1.7	0.1	1.3	0.7	0.7	0.7
Pavlov. Cond. index score	0.1	0.1	0.2	0.2	-0.2	0.5	-0.2	-0.3
Pavlov. Cond. latency score	0.1	0.1	0.3	0.2	-0.1	0.5	-0.2	-0.2
Pavlov. Cond. lever contacts	0.6	0.7	1.0	-1.0	0.8	-0.3	0.9	1.0
Pavlov. Cond. magazine entry number	0.3	0.4	0.9	-0.3	1.0	-0.3	0.7	0.7
Pavlov. Cond. intertrial magazine entries	4.0	4.8	8.3	-1.6	2.9	-0.8	2.4	2.5
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	0.3	-0.2	0.5	-0.2	-0.3
Pavlov. Cond. response bias	0.1	0.1	0.5	-0.7	-0.0	-0.2	0.3	0.4
Bone: apparent density	9.4	15.6	25.6	3.1	-5.1	1.6	-4.5	-4.4
Bone surface	2.9	5.0	12.3	1.0	-3.5	-0.2	-2.4	-2.4
Bone volume	5.4	9.1	18.6	1.9	-4.3	0.7	-3.4	-3.3
Bone: connectivity density	5.5	8.5	14.3	2.3	-3.8	0.9	-3.3	-3.4
Bone: cortical apparent density	3.9	5.1	10.2	2.8	-0.5	3.2	-1.9	-1.9
Bone: cortical area	1.3	2.0	5.7	0.1	-2.4	-1.0	-1.3	-1.2
Bone: cortical porosity	4.3	4.7	6.1	-2.3	1.9	-1.9	2.3	2.5
Bone: cortical porosity	3.4	3.7	5.0	-2.2	1.2	-2.0	1.9	2.1
Bone: cortical thickness	1.3	2.2	4.8	0.9	-2.2	0.3	-1.7	-1.5
Bone: cortical thickness	2.8	3.3	7.8	1.1	-2.8	-0.3	-2.0	-1.9
Bone: cortical tissue density	4.0	5.1	10.3	2.8	-0.5	3.2	-1.9	-1.9
Bone: elastic displacement	0.3	0.3	0.9	-0.2	-0.9	-0.3	-0.5	-0.4
Bone: elastic work	1.0	1.3	4.1	-0.6	-2.0	-0.9	-0.9	-0.8
Bone: endosteal estimation	0.4	0.8	2.7	-0.9	-0.7	-1.6	0.2	0.1
Bone: endosteal perimeter	0.5	1.0	2.5	-0.7	-1.4	-1.6	-0.3	-0.2
Bone: final force	1.4	2.3	7.0	-0.3	-2.6	-1.1	-1.3	-1.3
Bone: final moment	1.5	2.5	7.6	-0.2	-2.8	-0.9	-1.5	-1.4
Bone: marrow area	0.4	0.8	2.5	-0.9	-0.8	-1.6	0.1	-0.0
Bone: maximum diameter	1.5	2.7	6.3	1.0	-2.5	-0.1	-1.8	-1.7
Bone: maximum force	0.8	1.4	3.4	-0.7	-1.9	-1.5	-0.6	-0.7
Bone: maximum moment	0.8	1.3	3.5	-0.7	-1.9	-1.2	-0.7	-0.8
Bone: minimum diameter	1.0	1.9	6.5	-1.3	-1.2	-2.5	0.2	0.2
Bone: periosteal estimation	0.6	1.3	2.9	-0.6	-1.7	-1.7	-0.5	-0.5
Bone: periosteal perimeter	1.1	1.8	5.4	-0.1	-2.3	-1.0	-1.2	-1.2
Bone: post-yield work	2.0	2.7	3.4	-1.7	1.3	-1.9	1.8	1.4
Bone: stiffness	0.1	0.2	0.3	-0.5	-0.5	-0.6	-0.0	-0.1
Bone: tissue strength	0.4	0.3	0.5	-0.7	0.7	0.1	0.6	0.6
Bone: trabecular number	11.8	18.3	30.8	3.3	-5.5	1.6	-4.9	-4.8
Bone: trabecular spacing	7.6	9.9	14.7	-2.8	3.8	-1.2	3.5	3.7
Bone: trabecular thickness	14.4	17.5	22.3	3.8	-4.7	2.7	-4.7	-4.6
Bone: trabecular tissue density	0.6	0.8	2.7	0.1	1.6	0.6	0.8	0.6
Breakpoint value in progressive ratio session	0.4	0.5	0.8	-0.9	0.7	-0.3	0.8	0.6
Distance traveled before self-admin	0.2	0.2	0.7	0.4	0.1	0.8	-0.2	-0.1
Distance traveled after self-admin	0.6	0.7	2.3	0.7	0.1	1.5	-0.5	-0.6
Delta time in closed arm before/after self-admin	0.4	0.4	0.8	0.4	-0.9	-0.4	-0.7	-0.5
Delta time in open arm before/after self-admin	0.4	0.4	1.0	-1.0	0.3	-0.3	0.6	0.6
Diff in mean of infusions in LGA sessions	0.9	1.0	1.6	-1.3	0.6	-1.0	1.0	1.0
Extinction: sum of active levers before priming	2.9	2.9	4.2	-1.8	2.0	-0.7	2.0	1.6
Active lever presses in extinction session 6	0.1	0.1	0.2	-0.1	-0.2	-0.4	-0.0	-0.4
Delta distance traveled before/after self-admin	1.7	1.9	3.5	1.2	-0.7	1.9	-1.2	-1.5
Delta ambulatory time before/after self-admin	2.4	2.6	5.1	1.3	-0.9	2.3	-1.4	-1.9
Time in closed arm before self-admin	0.3	0.3	0.7	0.2	-0.4	0.7	-0.4	-0.8
Time in closed arm after self-admin	0.4	0.4	0.7	0.8	-0.2	0.6	-0.6	-0.8
Time in open arm before self-admin	0.3	0.3	0.8	0.1	0.2	-0.9	0.3	0.7
Time in open arm after self-admin	0.3	0.3	0.7	-0.7	-0.3	-0.8	0.2	0.7
Sum of active levers in priming session hrs 5-6	1.9	1.9	4.4	-0.8	2.1	-0.3	1.7	1.3
Time to tail flick, vehicle, before self-admin	0.7	0.7	0.9	1.0	-0.8	0.6	-0.9	-0.9
Time to tail flick, vehicle, after self-admin	3.5	3.7	4.9	-1.6	2.1	-1.7	2.2	1.9
Time to tail flick, test, before self-admin	1.0	1.0	1.8	-0.8	1.3	-0.7	1.3	0.7
Time to tail flick, test, after self-admin	0.5	0.5	1.5	-0.2	0.8	1.2	0.4	-0.5
Delta time to tail flick, vehicle, before/after SA	3.4	3.3	4.8	-1.8	2.2	-1.0	2.1	1.8
Delta time to tail flick, test, before/after SA	0.9	0.8	1.9	1.0	-0.1	1.4	-0.7	-0.9
Ambulatory time before self-admin	0.0	0.0	0.1	0.2	0.1	-0.1	0.1	0.3
Ambulatory time after self-admin	1.8	2.0	4.3	1.4	-0.6	2.1	-1.3	-1.4
Total heroin consumption	0.1	0.1	0.2	-0.4	-0.1	0.4	0.0	-0.3
Area under the delay curve	0.1	0.1	0.1	0.3	-0.4	-0.2	-0.3	-0.3
Delay disc. indifference point, 0s delay	0.7	0.8	2.0	-0.2	-1.4	0.2	-0.9	-1.0
Delay disc. indifference point, 16s delay	0.2	0.2	0.8	0.9	0.4	0.1	-0.1	0.2
Delay disc. indifference point, 2s delay	0.4	0.4	1.0	-0.6	-1.0	-0.4	-0.3	-0.7
Delay disc. indifference point, 24s delay	0.2	0.2	0.4	0.6	0.6	-0.1	0.2	0.4
Delay disc. indifference point, 4s delay	0.5	0.5	1.4	-0.1	-1.2	-0.6	-0.6	-0.6
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	-0.0	0.1	-0.1	0.1	-0.1
Delay discount exponential model param	0.0	0.0	0.2	-0.0	0.1	0.4	0.0	0.0
Delay discount hyperbolic model param	0.1	0.1	0.4	0.2	0.2	0.7	-0.0	0.0
Fecal boli incidents, locomotor time 1	0.2	0.2	0.8	0.1	0.9	0.2	0.5	-0.0
Change in fecal boli incidents, locomotor task	2.9	2.7	3.4	1.8	-1.5	1.3	-1.8	-1.7
Time >=10cm from walls, locomotor time 1	2.0	2.0	3.2	1.5	-0.9	1.8	-1.4	-1.2
Bouts of movement, locomotor time 1	0.1	0.2	0.8	-0.9	-0.2	0.0	0.1	-0.1
Total resting periods, locomotor time 1	0.4	0.5	0.8	-0.2	-0.9	0.6	-0.6	-0.9
Rest time, locomotor task time 1	0.9	1.0	2.2	0.1	-1.5	0.6	-1.1	-1.1
Distance moved, locomotor task time 1	0.8	0.8	2.0	0.1	1.4	-0.4	1.0	1.0
Vertical activity count, locomotor time 1	1.7	1.8	3.4	-0.7	1.8	-0.7	1.5	1.6
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	0.1	-0.3	0.4	-0.4	-0.3
Bouts of movement, locomotor time 2	1.1	1.2	1.9	-1.4	1.1	-0.2	1.1	1.4
Total resting periods, locomotor time 2	0.8	0.9	1.6	-1.2	0.7	-0.3	0.8	1.2
Rest time, locomotor task time 2	1.2	1.4	4.0	0.1	-2.0	0.4	-1.4	-1.1
Distance moved, locomotor task time 2	0.5	0.6	1.5	0.1	1.2	-0.4	0.8	0.8
Vertical activity count, locomotor time 2	0.4	0.4	1.0	-0.0	1.0	-0.2	0.7	0.8
Weight adjusted by age	0.5	0.6	1.3	0.5	-1.1	-0.1	-0.8	-0.9
Seeking ratio, delayed vs. immediate footshock	2.0	2.3	2.9	1.6	-1.0	1.7	-1.5	-1.6
Locomotion in novel chamber	0.7	0.9	3.6	0.1	0.4	1.9	-0.2	-0.9
Locomotion in novel chamber post-restriction	0.0	0.1	0.2	-0.4	0.1	0.4	-0.0	-0.0
Progressive ratio	0.1	0.1	0.3	0.4	-0.4	-0.5	-0.3	-0.1
Food seeking constrained by brief footshock	0.0	0.0	0.1	-0.3	-0.2	0.0	-0.1	-0.1
Seeking ratio, punishment vs. effort	0.3	0.3	0.7	-0.8	0.6	0.1	0.6	0.3
Run reversals in cocaine runway, females	1.2	1.2	2.1	-1.0	1.5	-0.1	1.3	1.1
Run reversals in cocaine runway, males	0.2	0.2	0.5	-0.1	0.6	0.7	0.3	-0.1
Latency to leave start box in cocaine runway	0.4	0.5	1.5	1.2	-0.0	0.6	-0.5	-0.6
Latency to leave start box in cocaine runway, F	1.2	1.3	2.4	1.5	-0.6	1.0	-1.0	-1.3
Latency to leave start box in cocaine runway, M	0.3	0.3	0.8	0.0	0.9	-0.1	0.6	0.5
Cd content in liver	0.1	0.1	0.5	0.0	0.4	0.7	0.1	0.3
Co content in liver	1.1	1.3	2.0	-0.9	1.4	-0.6	1.3	1.3
Cu content in liver	0.6	0.7	1.5	-0.7	0.5	-1.2	0.7	0.8
Fe content in liver	2.1	2.5	4.0	2.0	-1.4	1.0	-1.7	-1.6
K content in liver	1.4	1.4	2.4	-1.5	0.6	-1.2	1.0	1.4
Mg content in liver	2.3	2.4	3.2	-1.5	1.3	-1.6	1.6	1.8
Mn content in liver	0.0	0.0	0.1	0.2	-0.2	-0.3	-0.1	-0.2
Na content in liver	0.2	0.2	0.5	-0.6	-0.6	-0.7	-0.0	0.2
Rb content in liver	0.1	0.2	0.5	0.2	0.7	-0.4	0.4	0.2
Se content in liver	1.1	1.3	2.6	1.6	-0.4	1.5	-1.0	-0.9
Sr content in liver	1.0	0.9	2.0	0.8	-0.6	1.4	-0.9	-0.7
Zn content in liver	0.2	0.2	0.5	0.3	0.7	0.7	0.2	0.3