| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | BLA | mRNA stability | ENSRNOG00000012788 | 0.1800 | 0.0990 | 1.9e-05 | 0.100 | 0.078 | 0.057 | 0.082 | 5.5e-06 | 5.7e-05 | 5.1e-04 | 3.5e-05 |
| 2 | Brain | mRNA stability | ENSRNOG00000012788 | 0.3800 | 0.1275 | 0.0e+00 | 0.379 | 0.355 | 0.355 | 0.361 | 6.3e-37 | 3.7e-34 | 3.8e-34 | 8.1e-35 |
| 3 | IL | mRNA stability | ENSRNOG00000012788 | 0.2850 | 0.1540 | 2.5e-03 | 0.068 | 0.037 | -0.002 | 0.058 | 1.0e-02 | 4.5e-02 | 3.5e-01 | 1.6e-02 |
| 4 | NAcc | mRNA stability | ENSRNOG00000012788 | 0.0807 | 0.0526 | 6.3e-05 | 0.052 | 0.054 | 0.057 | 0.058 | 1.0e-04 | 6.8e-05 | 4.2e-05 | 4.1e-05 |
| 5 | OFC | mRNA stability | ENSRNOG00000012788 | 0.2046 | 0.1151 | 9.5e-04 | 0.108 | 0.069 | 0.028 | 0.079 | 1.6e-03 | 1.0e-02 | 7.3e-02 | 6.3e-03 |
| 6 | PL | mRNA stability | ENSRNOG00000012788 | 0.1679 | 0.0980 | 2.4e-10 | 0.119 | 0.124 | 0.133 | 0.131 | 2.4e-09 | 1.1e-09 | 2.8e-10 | 3.7e-10 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 |
|---|---|---|---|---|---|---|---|---|---|
| Pavlov. Cond. magazine entry number | 8.5 | 10.5 | 14.6 | 3.4 | 3.7 | 0.0 | 3.0 | 3.8 | 3.8 |
| Pavlov. Cond. response bias | 7.9 | 10.9 | 19.5 | -3.0 | -3.4 | 0.0 | -3.7 | -3.4 | -4.4 |
| Pavlov. Cond. lever latency | 7.6 | 10.4 | 19.0 | 2.9 | 3.3 | 0.0 | 3.6 | 3.3 | 4.4 |
| Retroperitoneal fat weight | 7.5 | 24.7 | 31.9 | 5.4 | 5.6 | 0.0 | 5.6 | 5.3 | 5.3 |
| Total locomotion distance, hab. session 1 | 7.4 | 10.7 | 14.2 | 3.6 | 3.7 | 0.0 | 3.4 | 3.4 | 3.8 |
| BMI without tail | 7.1 | 14.8 | 18.9 | 4.2 | 4.4 | 0.0 | 4.3 | 4.2 | 4.0 |
| Pavlov. Cond. index score | 6.9 | 9.0 | 15.3 | -2.8 | -3.2 | 0.0 | -3.1 | -3.3 | -3.9 |
| Pavlov. Cond. latency score | 6.9 | 8.7 | 14.3 | -2.8 | -3.1 | 0.0 | -3.0 | -3.3 | -3.8 |
| Locomotion velocity, session 8 | 6.8 | 8.1 | 11.9 | -3.2 | -3.2 | 0.0 | -2.7 | -3.5 | -3.1 |
| Pavlov. Cond. lever contacts | 6.6 | 9.2 | 17.5 | -2.7 | -3.0 | 0.0 | -3.4 | -3.0 | -4.2 |
| Locomotion velocity, hab. session 1 | 6.4 | 9.2 | 12.8 | 3.3 | 3.4 | 0.0 | 3.1 | 3.2 | 3.6 |
| Pavlov. Cond. lever-magazine prob. diff. | 6.2 | 8.0 | 13.8 | -2.6 | -3.0 | 0.0 | -2.9 | -3.1 | -3.7 |
| Liver weight, right | 5.9 | 9.7 | 13.5 | 3.7 | 3.6 | 0.0 | 3.1 | 3.3 | 3.4 |
| Locomotion velocity, hab. session 2 | 5.9 | 8.0 | 11.3 | 3.2 | 3.4 | 0.0 | 3.0 | 2.9 | 3.0 |
| Condit. Reinf. lever presses | 5.4 | 7.4 | 14.6 | -2.3 | -2.7 | 0.0 | -3.3 | -2.6 | -3.8 |
| Total locomotion distance, hab. session 2 | 5.3 | 7.1 | 9.8 | 3.0 | 3.1 | 0.0 | 2.8 | 2.7 | 2.9 |
| Locomotion in novel chamber post-restriction | 5.1 | 6.1 | 8.9 | -3.0 | -2.4 | 0.0 | -2.7 | -2.9 | -2.4 |
| Locomotion velocity, NPP test | 5.0 | 7.1 | 10.6 | 2.8 | 3.0 | 0.0 | 2.9 | 2.6 | 3.3 |
| Pavlov. Cond. magazine entry latency | 4.7 | 5.3 | 7.9 | -2.5 | -2.4 | 0.0 | -2.1 | -2.8 | -2.8 |
| Intraocular pressure | 4.6 | 6.5 | 9.3 | -3.0 | -2.8 | 0.0 | -2.3 | -3.0 | -2.7 |
| Delta time to tail flick, vehicle, before/after SA | 4.3 | 4.2 | 5.6 | -2.2 | -2.1 | 0.0 | -2.4 | -2.3 | -2.2 |
| Pavlov. Cond. change in total contacts | 4.2 | 5.9 | 10.5 | -2.1 | -2.5 | 0.0 | -2.7 | -2.6 | -3.2 |
| Intermittent access day 15 total infusions | 4.2 | 4.7 | 7.6 | -2.2 | -2.2 | 0.0 | -2.8 | -2.2 | -2.5 |
| Total locomotion distance, NPP test | 4.0 | 5.5 | 8.2 | 2.5 | 2.7 | 0.0 | 2.6 | 2.3 | 2.9 |
| Intermittent access intake escalation | 3.6 | 3.5 | 6.6 | -1.7 | -1.9 | 0.0 | -2.6 | -1.7 | -2.2 |
| Short access day 1 locomotion | 3.5 | 3.7 | 5.6 | -2.1 | -2.0 | 0.0 | -2.4 | -2.1 | -2.0 |
| Conditioned reinforcement - actives | 3.3 | 3.3 | 4.5 | -2.1 | -2.0 | 0.0 | -2.1 | -2.0 | -1.6 |
| Pavlov. Cond. intertrial magazine entries | 3.2 | 4.1 | 6.3 | 2.2 | 2.5 | 0.0 | 1.7 | 2.5 | 2.1 |
| Intermittent access intake day 1-15 change | 3.2 | 3.2 | 5.9 | -1.6 | -1.8 | 0.0 | -2.4 | -1.6 | -2.1 |
| Epididymis fat weight | 3.0 | 7.0 | 9.6 | 3.1 | 2.9 | 0.0 | 2.6 | 3.0 | 2.9 |
| Conditioned locomotion | 3.0 | 3.6 | 4.9 | -2.2 | -2.1 | 0.0 | -2.2 | -2.2 | -1.7 |
| Degree of sensitization stereotypy | 3.0 | 3.3 | 4.9 | -2.0 | -2.1 | 0.0 | -2.2 | -1.8 | -1.8 |
| Bone: trabecular tissue density | 3.0 | 4.1 | 6.8 | 2.3 | 2.1 | 0.0 | 2.6 | 2.1 | 2.1 |
| Body weight | 2.7 | 11.3 | 15.6 | 3.9 | 3.9 | 0.0 | 3.7 | 3.6 | 3.1 |
| Parametrial fat weight | 2.6 | 5.1 | 8.4 | 2.4 | 2.9 | 0.0 | 2.5 | 2.0 | 2.5 |
| Context. condit. distance diff. score | 2.6 | 3.1 | 5.1 | -2.1 | -1.9 | 0.0 | -1.7 | -2.3 | -1.7 |
| Fecal boli incidents, locomotor time 1 | 2.5 | 2.7 | 3.7 | -1.9 | -1.8 | 0.0 | -1.7 | -1.9 | -1.5 |
| Run reversals in cocaine runway, males | 2.5 | 2.4 | 3.3 | -1.6 | -1.8 | 0.0 | -1.6 | -1.6 | -1.8 |
| Food consumed during 24 hour testing period | 2.4 | 2.9 | 4.7 | -2.0 | -1.9 | 0.0 | -2.2 | -1.4 | -1.8 |
| Social responses | 2.4 | 3.1 | 4.7 | 2.2 | 2.0 | 0.0 | 1.6 | 2.1 | 1.6 |
| Locomotion distance, session 3 | 2.4 | 2.6 | 3.9 | -2.0 | -1.7 | 0.0 | -1.6 | -1.9 | -1.6 |
| Stereotopy head waving bouts, day 3 | 2.4 | 2.9 | 4.6 | 1.9 | 1.9 | 0.0 | 1.4 | 2.1 | 1.9 |
| Seeking ratio, punishment vs. effort | 2.3 | 2.8 | 5.3 | 2.2 | 2.0 | 0.0 | 1.0 | 2.3 | 1.3 |
| Tail length | 2.2 | 6.8 | 10.2 | 3.1 | 3.2 | 0.0 | 2.5 | 3.2 | 2.2 |
| Time in closed arm after self-admin | 2.2 | 2.3 | 3.2 | -1.7 | -1.6 | 0.0 | -1.4 | -1.8 | -1.7 |
| Time to tail flick, vehicle, after self-admin | 2.2 | 2.3 | 3.7 | -1.5 | -1.4 | 0.0 | -1.9 | -1.5 | -1.9 |
| Locomotor testing rearing | 2.1 | 3.3 | 4.6 | 2.1 | 2.0 | 0.0 | 2.2 | 2.0 | 1.7 |
| Baseline Anxiety | 2.1 | 2.2 | 3.7 | -1.3 | -1.6 | 0.0 | -1.9 | -1.3 | -1.9 |
| Number of licking bursts | 2.0 | 2.4 | 3.1 | 1.8 | 1.6 | 0.0 | 1.8 | 1.6 | 1.7 |
| Light reinforcement 1 | 2.0 | 3.6 | 5.1 | 2.0 | 2.1 | 0.0 | 2.1 | 1.9 | 2.3 |
| Diff in mean of infusions in LGA sessions | 2.0 | 2.2 | 3.9 | 1.6 | 1.3 | 0.0 | 2.0 | 1.3 | 1.8 |
| Run reversals in cocaine runway, females | 2.0 | 2.0 | 3.6 | 1.5 | 1.2 | 0.0 | 1.9 | 1.7 | 1.3 |
| Delay disc. indifference point, 16s delay | 1.9 | 1.9 | 3.8 | -1.2 | -1.2 | 0.0 | -1.8 | -1.2 | -1.9 |
| Length with tail | 1.8 | 6.7 | 9.6 | 3.1 | 3.1 | 0.0 | 2.6 | 3.1 | 2.2 |
| Delay discounting water rate 24 sec | 1.8 | 2.4 | 3.4 | -1.8 | -1.7 | 0.0 | -1.5 | -1.6 | -1.8 |
| Reaction time premature initiation rate | 1.8 | 2.4 | 4.3 | 2.1 | 2.0 | 0.0 | 1.1 | 1.9 | 1.1 |
| Social response proportion | 1.8 | 2.0 | 2.8 | 1.6 | 1.5 | 0.0 | 1.2 | 1.7 | 1.7 |
| Intermittent access terminal intake (last 3 days) | 1.8 | 2.0 | 3.7 | -1.4 | -1.3 | 0.0 | -1.9 | -1.3 | -1.6 |
| Degree of sensitization distance | 1.8 | 1.8 | 2.5 | 1.5 | 1.5 | 0.0 | 1.6 | 1.3 | 1.3 |
| Locomotion in novel chamber | 1.8 | 2.2 | 4.0 | -2.0 | -1.3 | 0.0 | -1.4 | -2.0 | -1.2 |
| Delay disc. indifference point, 8s delay | 1.6 | 1.7 | 2.9 | -1.3 | -1.3 | 0.0 | -1.4 | -1.3 | -1.7 |
| Locomotion velocity, session 1 | 1.5 | 1.6 | 2.3 | -1.5 | -1.5 | 0.0 | -1.4 | -1.4 | -1.2 |
| Progressive ratio | 1.5 | 1.8 | 3.3 | -1.7 | -1.6 | 0.0 | -0.8 | -1.8 | -1.1 |
| Latency to leave start box in cocaine runway, F | 1.5 | 1.7 | 3.0 | 1.5 | 1.0 | 0.0 | 1.4 | 1.3 | 1.7 |
| BMI with tail | 1.3 | 4.3 | 6.3 | 2.3 | 2.4 | 0.0 | 2.5 | 2.0 | 2.2 |
| Mean num. licks in bursts | 1.3 | 1.6 | 2.3 | -1.5 | -1.4 | 0.0 | -1.4 | -1.2 | -1.4 |
| Delay discounting water rate 12 sec | 1.3 | 1.9 | 3.2 | -1.6 | -1.2 | 0.0 | -1.5 | -1.5 | -1.8 |
| Reaction time num false alarms | 1.3 | 1.7 | 3.2 | 1.1 | 1.4 | 0.0 | 1.8 | 1.1 | 1.6 |
| Intermittent access day 15 total locomotion | 1.3 | 1.4 | 2.3 | -1.2 | -1.1 | 0.0 | -1.5 | -1.1 | -1.3 |
| Number of responses in last shaping day | 1.3 | 1.3 | 1.8 | 1.4 | 1.2 | 0.0 | 1.0 | 1.4 | 1.3 |
| Latency to leave start box in cocaine runway | 1.3 | 1.4 | 2.3 | 1.4 | 1.0 | 0.0 | 1.2 | 1.3 | 1.5 |
| Delay discounting water rate 6 sec | 1.2 | 1.7 | 2.6 | -1.5 | -1.2 | 0.0 | -1.5 | -1.3 | -1.6 |
| Lifetime Intake | 1.2 | 1.4 | 2.2 | -1.3 | -1.1 | 0.0 | -1.5 | -1.2 | -1.2 |
| Total sessions with >9 infusions | 1.2 | 1.3 | 2.4 | -1.3 | -1.1 | 0.0 | -1.5 | -1.2 | -1.2 |
| Locomotion distance, session 8 | 1.2 | 1.8 | 2.7 | -1.5 | -1.3 | 0.0 | -1.4 | -1.6 | -1.5 |
| Condit. Reinf. active minus inactive responses | 1.2 | 1.3 | 2.5 | 1.0 | 1.4 | 0.0 | 1.6 | 1.0 | 1.2 |
| Time in open arm before self-admin | 1.2 | 1.3 | 1.9 | 1.3 | 1.1 | 0.0 | 1.4 | 1.2 | 1.2 |
| Area under the delay curve | 1.2 | 1.3 | 2.4 | -1.1 | -1.1 | 0.0 | -1.3 | -1.1 | -1.5 |
| Delay discount exponential model param | 1.2 | 1.3 | 2.3 | 1.1 | 1.1 | 0.0 | 1.3 | 1.1 | 1.5 |
| Time >=10cm from walls, locomotor time 1 | 1.2 | 1.2 | 1.8 | -1.3 | -1.4 | 0.0 | -0.8 | -1.3 | -1.0 |
| Std. dev. time between licks in bursts | 1.1 | 1.3 | 2.4 | 1.3 | 1.5 | 0.0 | 0.8 | 1.5 | 1.0 |
| Delay discounting time to switch 0 sec | 1.1 | 1.7 | 3.0 | 1.4 | 1.1 | 0.0 | 1.3 | 1.5 | 1.7 |
| Reaction time premature initiations | 1.1 | 1.5 | 2.7 | 1.6 | 1.7 | 0.0 | 0.7 | 1.6 | 0.8 |
| Social time | 1.1 | 1.4 | 2.1 | 1.4 | 1.2 | 0.0 | 1.0 | 1.3 | 1.4 |
| Condit. Reinf. active-inactive response ratio | 1.1 | 1.2 | 1.8 | 1.2 | 1.2 | 0.0 | 1.3 | 1.0 | 1.1 |
| Time in closed arm before self-admin | 1.1 | 1.3 | 2.5 | -1.0 | -1.2 | 0.0 | -1.6 | -1.0 | -1.3 |
| Time in open arm after self-admin | 1.1 | 1.3 | 1.8 | 1.2 | 1.1 | 0.0 | 1.3 | 1.1 | 1.3 |
| Delay discount hyperbolic model param | 1.1 | 1.2 | 2.1 | 1.1 | 1.1 | 0.0 | 1.2 | 1.1 | 1.4 |
| Rest time, locomotor task time 1 | 1.1 | 1.2 | 1.6 | -1.1 | -1.2 | 0.0 | -1.1 | -1.2 | -1.2 |
| Liver weight, left | 1.0 | 1.7 | 2.5 | 1.5 | 1.6 | 0.0 | 1.5 | 1.1 | 1.4 |
| Indifference point function ln k | 1.0 | 1.5 | 2.7 | -1.1 | -1.1 | 0.0 | -1.6 | -1.1 | -1.6 |
| Indifference point function log k | 1.0 | 1.5 | 2.7 | -1.1 | -1.1 | 0.0 | -1.6 | -1.1 | -1.6 |
| Delay discounting water rate 0 sec | 1.0 | 1.6 | 2.5 | -1.4 | -1.1 | 0.0 | -1.3 | -1.4 | -1.6 |
| Condit. Reinf. active responses | 1.0 | 1.2 | 2.1 | 0.9 | 1.3 | 0.0 | 1.5 | 1.0 | 1.3 |
| Times rat made contact with spout | 0.9 | 1.1 | 1.6 | 1.0 | 1.0 | 0.0 | 1.1 | 1.3 | 1.2 |
| Intermittent access total infusions | 0.9 | 1.0 | 1.7 | -1.1 | -1.0 | 0.0 | -1.3 | -1.1 | -1.0 |
| One hour access (shock baseline) | 0.9 | 1.0 | 1.8 | -0.9 | -0.9 | 0.0 | -1.3 | -0.9 | -1.2 |
| Bone: connectivity density | 0.9 | 1.4 | 2.1 | -1.5 | -1.2 | 0.0 | -1.4 | -1.4 | -1.0 |
| Sr content in liver | 0.9 | 0.8 | 1.1 | -1.1 | -1.0 | 0.0 | -0.9 | -1.0 | -0.9 |
| Soleus weight | 0.8 | 2.4 | 3.2 | 1.8 | 1.8 | 0.0 | 1.7 | 1.7 | 1.4 |
| Condit. Reinf. active-inactive response ratio | 0.8 | 0.8 | 1.4 | -0.9 | -1.0 | 0.0 | -0.7 | -1.2 | -1.1 |
| One hour access (0.3 mA shock) | 0.8 | 0.9 | 1.9 | -0.8 | -0.9 | 0.0 | -1.4 | -0.7 | -1.2 |
| Bone surface | 0.8 | 1.5 | 2.4 | -1.3 | -1.1 | 0.0 | -1.5 | -1.3 | -1.3 |
| Active lever presses in extinction session 6 | 0.8 | 0.7 | 1.7 | -0.5 | -1.3 | 0.0 | -1.3 | -0.5 | -0.8 |
| Total resting periods, locomotor time 1 | 0.8 | 0.9 | 1.2 | -1.0 | -1.1 | 0.0 | -0.9 | -1.0 | -1.1 |
| Cd content in liver | 0.8 | 0.9 | 1.6 | 0.9 | 0.9 | 0.0 | 1.3 | 0.8 | 1.2 |
| Change in fecal boli incidents, locomotor task | 0.7 | 0.7 | 1.2 | 1.1 | 1.0 | 0.0 | 0.6 | 1.1 | 0.5 |
| Tibia length | 0.6 | 1.8 | 2.4 | -1.5 | -1.3 | 0.0 | -1.5 | -1.6 | -1.4 |
| Condit. Reinf. active minus inactive responses | 0.6 | 0.7 | 1.6 | -0.5 | -0.6 | 0.0 | -1.0 | -1.0 | -1.3 |
| Condit. Reinf. lever reinforcers received | 0.6 | 0.9 | 2.5 | -0.4 | -0.5 | 0.0 | -1.3 | -0.9 | -1.6 |
| Cocaine induced anxiety | 0.6 | 0.7 | 1.2 | 0.7 | 1.0 | 0.0 | 1.1 | 0.8 | 1.0 |
| Short access day 10 total inactive lever presses | 0.6 | 0.7 | 1.4 | 1.1 | 0.7 | 0.0 | 0.6 | 1.2 | 0.8 |
| Short access day 1 total infusions | 0.6 | 0.7 | 1.5 | -0.8 | -0.7 | 0.0 | -1.2 | -0.7 | -0.9 |
| Locomotion velocity, session 2 | 0.6 | 0.7 | 1.4 | -0.9 | -1.2 | 0.0 | -0.8 | -0.7 | -0.8 |
| Stereotopy head waving duration, day 7 | 0.6 | 0.7 | 1.4 | -0.7 | -1.0 | 0.0 | -1.2 | -0.5 | -0.9 |
| Total zone transitions, NPP test | 0.6 | 0.8 | 1.6 | -1.0 | -0.7 | 0.0 | -0.9 | -1.3 | -1.1 |
| Pavlov. Cond. lever latency | 0.6 | 0.8 | 1.3 | 0.7 | 1.0 | 0.0 | 1.1 | 0.7 | 1.1 |
| Pavlov. Cond. intertrial magazine entries | 0.6 | 0.8 | 1.6 | 0.7 | 0.8 | 0.0 | 1.0 | 1.0 | 1.3 |
| Bone: elastic work | 0.6 | 0.7 | 1.1 | -0.9 | -0.8 | 0.0 | -1.0 | -0.9 | -1.0 |
| Time to tail flick, vehicle, before self-admin | 0.6 | 0.6 | 1.4 | 1.0 | 0.8 | 0.0 | 0.6 | 1.2 | 0.5 |
| Delay disc. indifference point, 2s delay | 0.6 | 0.6 | 0.9 | -0.9 | -0.7 | 0.0 | -0.9 | -0.8 | -0.9 |
| Distance moved, locomotor task time 1 | 0.6 | 0.6 | 0.8 | 0.9 | 0.9 | 0.0 | 0.8 | 0.9 | 0.7 |
| Heart weight | 0.5 | 0.7 | 1.2 | -0.8 | -0.7 | 0.0 | -1.0 | -0.9 | -1.1 |
| Condit. Reinf. active responses | 0.5 | 0.6 | 2.0 | -0.2 | -0.3 | 0.0 | -1.1 | -0.6 | -1.4 |
| Intermittent access day 1 total infusions | 0.5 | 0.6 | 0.9 | -1.0 | -0.7 | 0.0 | -0.7 | -0.9 | -0.8 |
| Intermittent access day 1 locomotion | 0.5 | 0.5 | 1.1 | -1.0 | -0.7 | 0.0 | -0.6 | -1.0 | -0.3 |
| Incentive Sensitization - Responses | 0.5 | 0.5 | 1.1 | -0.4 | -0.7 | 0.0 | -1.0 | -0.4 | -1.0 |
| Incentive Sensitization - Breakpoint | 0.5 | 0.5 | 1.3 | -0.5 | -0.8 | 0.0 | -1.1 | -0.4 | -1.0 |
| Progressive ratio test 2 active lever presses | 0.5 | 0.6 | 0.8 | -0.8 | -0.9 | 0.0 | -0.9 | -0.7 | -0.8 |
| Time in novel zone, hab. session 1 | 0.5 | 0.5 | 0.9 | 1.0 | 0.8 | 0.0 | 0.8 | 0.8 | 0.4 |
| Pavlov. Cond. change in total contacts | 0.5 | 0.5 | 0.9 | -0.7 | -0.9 | 0.0 | -0.8 | -0.8 | -0.6 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.5 | 0.6 | 1.1 | -0.6 | -0.9 | 0.0 | -0.9 | -0.6 | -1.1 |
| Bone: maximum force | 0.5 | 0.9 | 1.8 | -1.1 | -0.7 | 0.0 | -1.0 | -1.4 | -1.0 |
| Bone: maximum moment | 0.5 | 0.9 | 1.6 | -1.1 | -0.6 | 0.0 | -1.1 | -1.3 | -1.0 |
| Delay disc. indifference point, 4s delay | 0.5 | 0.5 | 1.0 | -0.6 | -0.7 | 0.0 | -0.8 | -0.6 | -1.0 |
| Left kidney weight | 0.4 | 1.0 | 2.0 | 1.3 | 1.3 | 0.0 | 0.8 | 1.4 | 0.5 |
| Right kidney weight | 0.4 | 1.1 | 2.4 | 1.5 | 1.3 | 0.0 | 0.6 | 1.6 | 0.6 |
| Water consumed over 24 hours | 0.4 | 0.4 | 0.8 | 0.6 | 0.5 | 0.0 | 0.8 | 0.9 | 0.8 |
| Indifference point 0 sec | 0.4 | 0.6 | 1.4 | -0.5 | -0.7 | 0.0 | -1.0 | -0.7 | -1.2 |
| Delay discounting total patch changes 0 sec | 0.4 | 0.6 | 1.3 | -0.6 | -0.7 | 0.0 | -0.9 | -0.8 | -1.1 |
| Delay discounting water rate 18 sec | 0.4 | 0.5 | 1.0 | -0.9 | -0.5 | 0.0 | -0.6 | -0.7 | -1.0 |
| Reaction time mean | 0.4 | 0.5 | 1.4 | 1.2 | 0.8 | 0.0 | 0.6 | 0.7 | 0.7 |
| Intermittent access intake escalation 2 | 0.4 | 0.4 | 1.2 | -0.4 | -0.5 | 0.0 | -1.1 | -0.4 | -0.7 |
| Progressive ratio test 2 inactive lever presses | 0.4 | 0.5 | 1.1 | -0.6 | -0.7 | 0.0 | -1.1 | -0.5 | -0.9 |
| Short access day 10 total infusions | 0.4 | 0.5 | 0.9 | -1.0 | -0.6 | 0.0 | -0.7 | -0.9 | -0.6 |
| Locomotion distance, session 1 | 0.4 | 0.6 | 0.9 | -0.8 | -0.7 | 0.0 | -0.9 | -1.0 | -0.8 |
| Locomotion velocity, session 7 | 0.4 | 0.5 | 0.7 | -0.8 | -0.8 | 0.0 | -0.5 | -0.8 | -0.7 |
| Stereotopy head waving bouts, day 7 | 0.4 | 0.4 | 1.0 | -0.7 | -0.9 | 0.0 | -1.0 | -0.4 | -0.5 |
| Pavlov. Cond. index score | 0.4 | 0.5 | 1.1 | -0.5 | -0.8 | 0.0 | -0.9 | -0.6 | -1.0 |
| Pavlov. Cond. magazine entry number | 0.4 | 0.5 | 1.2 | 0.5 | 0.7 | 0.0 | 0.9 | 0.7 | 1.1 |
| Bone: cortical thickness | 0.4 | 0.5 | 1.2 | -0.8 | -0.5 | 0.0 | -0.7 | -1.1 | -0.6 |
| Bone: endosteal perimeter | 0.4 | 0.8 | 1.4 | -1.1 | -0.7 | 0.0 | -0.9 | -1.0 | -1.2 |
| Bone: minimum diameter | 0.4 | 0.7 | 1.5 | 0.8 | 1.2 | 0.0 | 0.8 | 0.7 | 0.9 |
| Sum of active levers in priming session hrs 5-6 | 0.4 | 0.4 | 0.9 | 0.9 | 0.4 | 0.0 | 0.4 | 0.9 | 0.6 |
| Time to tail flick, test, before self-admin | 0.4 | 0.3 | 0.9 | -0.7 | -0.3 | 0.0 | 1.0 | -0.7 | 0.4 |
| Bouts of movement, locomotor time 1 | 0.4 | 0.5 | 0.7 | -0.7 | -0.8 | 0.0 | -0.7 | -0.7 | -0.8 |
| Bouts of movement, locomotor time 2 | 0.4 | 0.4 | 1.5 | 0.2 | 0.3 | 0.0 | -1.2 | 0.3 | -0.8 |
| Rest time, locomotor task time 2 | 0.4 | 0.4 | 1.0 | 0.6 | 0.5 | 0.0 | 0.8 | 0.6 | 1.0 |
| Na content in liver | 0.4 | 0.4 | 1.6 | -0.3 | -0.7 | 0.0 | -1.3 | -0.1 | -0.4 |
| Se content in liver | 0.4 | 0.5 | 1.2 | 0.6 | 0.3 | 0.0 | 0.6 | 0.8 | 1.1 |
| Zn content in liver | 0.4 | 0.4 | 1.2 | -0.3 | -0.5 | 0.0 | -1.1 | -0.3 | -1.0 |
| Glucose | 0.3 | 0.4 | 0.7 | -0.7 | -0.7 | 0.0 | -0.5 | -0.9 | -0.8 |
| Locomotor activity | 0.3 | 0.4 | 1.2 | 0.8 | 0.8 | 0.0 | 0.3 | 1.1 | 0.2 |
| Light reinforcement 2 | 0.3 | 0.3 | 0.8 | 0.3 | 0.8 | 0.0 | 0.7 | 0.1 | 0.9 |
| Std. dev. reaction times | 0.3 | 0.4 | 0.9 | 0.9 | 0.8 | 0.0 | 0.5 | 0.7 | 0.3 |
| Cocaine response before conditioning | 0.3 | 0.3 | 1.5 | -0.3 | -0.4 | 0.0 | -1.2 | -0.3 | -0.3 |
| Condit. Reinf. inactive responses | 0.3 | 0.4 | 0.8 | 0.8 | 0.7 | 0.0 | -0.6 | 0.9 | -0.5 |
| Intermitt. access day 1 inactive lever presses | 0.3 | 0.3 | 0.7 | 0.7 | 0.6 | 0.0 | 0.3 | 0.7 | 0.8 |
| Intermittent access total locomotion | 0.3 | 0.4 | 0.6 | -0.7 | -0.6 | 0.0 | -0.8 | -0.7 | -0.5 |
| Progressive ratio test 2 breakpoint | 0.3 | 0.3 | 0.5 | -0.5 | -0.7 | 0.0 | -0.7 | -0.4 | -0.6 |
| Short access day 1 total inactive lever presses | 0.3 | 0.4 | 0.7 | -0.6 | -0.8 | 0.0 | -0.7 | -0.6 | -0.6 |
| Short access total infusions | 0.3 | 0.3 | 0.5 | -0.7 | -0.5 | 0.0 | -0.7 | -0.6 | -0.5 |
| Locomotion velocity, session 3 | 0.3 | 0.4 | 0.5 | -0.7 | -0.7 | 0.0 | -0.7 | -0.7 | -0.7 |
| Incentive salience index mean | 0.3 | 0.4 | 0.9 | 0.5 | 0.8 | 0.0 | 0.9 | 0.4 | 0.6 |
| Pavlov. Cond. latency score | 0.3 | 0.4 | 0.9 | -0.4 | -0.7 | 0.0 | -0.8 | -0.6 | -1.0 |
| Pavlov. Cond. lever contacts | 0.3 | 0.4 | 0.8 | -0.5 | -0.8 | 0.0 | -0.8 | -0.4 | -0.9 |
| Bone volume | 0.3 | 0.5 | 0.8 | -0.9 | -0.6 | 0.0 | -0.8 | -0.7 | -0.8 |
| Bone: cortical apparent density | 0.3 | 0.4 | 0.8 | 0.6 | 0.4 | 0.0 | 0.9 | 0.7 | 0.6 |
| Bone: cortical porosity | 0.3 | 0.3 | 1.3 | -0.3 | -0.5 | 0.0 | -1.1 | -0.2 | -0.7 |
| Total resting periods, locomotor time 2 | 0.3 | 0.3 | 1.4 | 0.1 | 0.2 | 0.0 | -1.2 | 0.2 | -0.7 |
| K content in liver | 0.3 | 0.3 | 1.0 | 0.8 | 0.5 | 0.0 | -0.1 | 1.0 | 0.4 |
| Tibialis anterior weight | 0.2 | 0.7 | 1.1 | 1.0 | 1.0 | 0.0 | 0.9 | 0.9 | 0.8 |
| Mean time between licks in bursts | 0.2 | 0.2 | 0.7 | 0.1 | 0.3 | 0.0 | -0.9 | 0.3 | -0.7 |
| Locomotor testing distance | 0.2 | 0.3 | 0.6 | 0.7 | 0.6 | 0.0 | 0.3 | 0.8 | 0.0 |
| Reaction time num false alarms AUC | 0.2 | 0.3 | 0.7 | 0.3 | 0.6 | 0.0 | 0.8 | 0.4 | 0.8 |
| Reaction time mean AUC | 0.2 | 0.3 | 0.8 | 0.9 | 0.4 | 0.0 | 0.4 | 0.5 | 0.5 |
| Median of all reaction times | 0.2 | 0.3 | 1.0 | 1.0 | 0.5 | 0.0 | 0.4 | 0.5 | 0.6 |
| Reaction time false alarm rate | 0.2 | 0.3 | 0.7 | 0.4 | 0.5 | 0.0 | 0.9 | 0.3 | 0.8 |
| Locomotion distance, session 7 | 0.2 | 0.3 | 0.8 | -0.7 | -0.4 | 0.0 | -0.1 | -0.9 | -0.4 |
| Condit. Reinf. lever presses | 0.2 | 0.3 | 0.7 | -0.8 | -0.5 | 0.0 | -0.4 | -0.7 | -0.6 |
| Time in familiar zone, hab. session 2 | 0.2 | 0.2 | 0.4 | -0.5 | -0.5 | 0.0 | -0.4 | -0.3 | -0.6 |
| Bone: cortical porosity | 0.2 | 0.2 | 1.0 | -0.2 | -0.4 | 0.0 | -1.0 | -0.1 | -0.4 |
| Bone: cortical thickness | 0.2 | 0.4 | 0.8 | 0.5 | 0.7 | 0.0 | 0.7 | 0.4 | 0.9 |
| Bone: cortical tissue density | 0.2 | 0.3 | 0.7 | 0.5 | 0.3 | 0.0 | 0.9 | 0.7 | 0.5 |
| Bone: maximum diameter | 0.2 | 0.3 | 0.5 | -0.6 | -0.1 | 0.0 | -0.5 | -0.7 | -0.7 |
| Bone: post-yield work | 0.2 | 0.2 | 0.5 | -0.4 | -0.2 | 0.0 | -0.7 | -0.6 | -0.4 |
| Bone: tissue strength | 0.2 | 0.1 | 0.7 | -0.2 | -0.1 | 0.0 | -0.8 | -0.4 | -0.2 |
| Bone: trabecular spacing | 0.2 | 0.2 | 0.4 | -0.5 | -0.4 | 0.0 | -0.6 | -0.4 | -0.6 |
| Breakpoint value in progressive ratio session | 0.2 | 0.2 | 0.8 | -0.5 | -0.9 | 0.0 | 0.0 | -0.5 | 0.0 |
| Delta time in closed arm before/after self-admin | 0.2 | 0.1 | 0.5 | 0.3 | 0.4 | 0.0 | 0.7 | 0.2 | -0.3 |
| Delta ambulatory time before/after self-admin | 0.2 | 0.2 | 0.5 | -0.2 | -0.1 | 0.0 | -0.7 | -0.3 | -0.6 |
| Delay disc. indifference point, 24s delay | 0.2 | 0.2 | 0.5 | -0.5 | -0.5 | 0.0 | -0.4 | -0.5 | -0.7 |
| Vertical activity count, locomotor time 1 | 0.2 | 0.2 | 0.4 | 0.5 | 0.6 | 0.0 | 0.4 | 0.6 | 0.3 |
| Weight adjusted by age | 0.2 | 0.2 | 0.3 | 0.6 | 0.5 | 0.0 | 0.6 | 0.4 | 0.5 |
| Food seeking constrained by brief footshock | 0.2 | 0.2 | 0.4 | 0.7 | 0.6 | 0.0 | 0.4 | 0.5 | 0.1 |
| Cu content in liver | 0.2 | 0.2 | 0.7 | 0.6 | 0.3 | 0.0 | 0.4 | 0.8 | -0.0 |
| Fe content in liver | 0.2 | 0.2 | 0.3 | -0.5 | -0.4 | 0.0 | -0.6 | -0.5 | -0.5 |
| Mg content in liver | 0.2 | 0.2 | 0.7 | 0.1 | -0.2 | 0.0 | -0.8 | 0.1 | -0.5 |
| Extensor digitorum longus weight | 0.1 | 0.6 | 1.1 | 0.9 | 0.8 | 0.0 | 1.0 | 0.7 | 0.6 |
| Delay discounting total patch changes 12 sec | 0.1 | 0.1 | 0.2 | 0.3 | 0.3 | 0.0 | 0.5 | 0.2 | 0.4 |
| Delay discounting total patch changes 18 sec | 0.1 | 0.1 | 0.2 | -0.3 | -0.5 | 0.0 | -0.1 | -0.1 | -0.4 |
| Delay discounting total patch changes 24 sec | 0.1 | 0.1 | 0.3 | 0.2 | 0.1 | 0.0 | 0.5 | 0.3 | 0.5 |
| Delay discounting total patch changes 6 sec | 0.1 | 0.1 | 0.2 | -0.1 | -0.1 | 0.0 | -0.4 | -0.3 | -0.5 |
| Reaction time omissions | 0.1 | 0.1 | 0.4 | 0.6 | 0.4 | 0.0 | -0.1 | 0.3 | -0.2 |
| Conditioned locomotion | 0.1 | 0.2 | 0.3 | -0.4 | -0.4 | 0.0 | -0.4 | -0.4 | -0.5 |
| Cocaine response after cond. corrected | 0.1 | 0.1 | 0.2 | 0.3 | 0.0 | 0.0 | 0.5 | 0.0 | 0.2 |
| Intermitt. access day 15 inactive lever presses | 0.1 | 0.1 | 0.3 | -0.1 | -0.4 | 0.0 | -0.6 | -0.1 | -0.5 |
| Short access day 10 total locomotion | 0.1 | 0.1 | 0.3 | -0.3 | -0.1 | 0.0 | -0.5 | -0.4 | -0.3 |
| Short access total locomotion | 0.1 | 0.1 | 0.2 | -0.3 | -0.1 | 0.0 | -0.4 | -0.3 | 0.1 |
| Total zone transitions, hab. session 1 | 0.1 | 0.1 | 0.2 | -0.2 | 0.1 | 0.0 | -0.3 | -0.5 | -0.3 |
| Total zone transitions, hab. session 2 | 0.1 | 0.2 | 0.4 | -0.3 | 0.0 | 0.0 | -0.5 | -0.6 | -0.6 |
| Novel to familiar place preference ratio | 0.1 | 0.1 | 0.2 | 0.3 | 0.4 | 0.0 | 0.2 | 0.1 | 0.2 |
| Pavlov. Cond. magazine entry latency | 0.1 | 0.2 | 0.4 | -0.3 | -0.3 | 0.0 | -0.5 | -0.5 | -0.6 |
| Pavlov. Cond. response bias | 0.1 | 0.1 | 0.3 | -0.2 | -0.4 | 0.0 | -0.5 | -0.2 | -0.6 |
| Bone: apparent density | 0.1 | 0.1 | 0.2 | -0.5 | -0.2 | 0.0 | -0.3 | -0.3 | -0.2 |
| Bone: cortical area | 0.1 | 0.1 | 0.3 | 0.2 | 0.6 | 0.0 | 0.4 | 0.0 | 0.4 |
| Bone: final force | 0.1 | 0.2 | 0.6 | -0.6 | -0.2 | 0.0 | -0.4 | -0.8 | -0.5 |
| Bone: final moment | 0.1 | 0.2 | 0.5 | -0.6 | -0.2 | 0.0 | -0.5 | -0.7 | -0.5 |
| Bone: periosteal perimeter | 0.1 | 0.2 | 0.6 | -0.5 | -0.1 | 0.0 | -0.6 | -0.4 | -0.7 |
| Bone: trabecular number | 0.1 | 0.1 | 0.3 | -0.5 | -0.2 | 0.0 | -0.2 | -0.5 | -0.1 |
| Bone: trabecular thickness | 0.1 | 0.2 | 0.6 | 0.4 | 0.2 | 0.0 | 0.8 | 0.4 | 0.2 |
| Distance traveled before self-admin | 0.1 | 0.1 | 0.2 | 0.3 | -0.0 | 0.0 | 0.2 | 0.4 | 0.3 |
| Distance traveled after self-admin | 0.1 | 0.1 | 0.2 | 0.4 | 0.2 | 0.0 | 0.1 | 0.5 | 0.4 |
| Delta time in open arm before/after self-admin | 0.1 | 0.1 | 0.2 | -0.3 | -0.4 | 0.0 | -0.4 | -0.3 | -0.2 |
| Delta distance traveled before/after self-admin | 0.1 | 0.1 | 0.3 | 0.3 | 0.3 | 0.0 | -0.5 | 0.2 | -0.3 |
| Time to tail flick, test, after self-admin | 0.1 | 0.1 | 0.2 | -0.5 | -0.1 | 0.0 | 0.3 | -0.3 | -0.1 |
| Delta time to tail flick, test, before/after SA | 0.1 | 0.1 | 0.1 | 0.3 | 0.1 | 0.0 | -0.4 | 0.3 | -0.1 |
| Ambulatory time before self-admin | 0.1 | 0.1 | 0.5 | -0.5 | -0.7 | 0.0 | -0.2 | -0.3 | -0.1 |
| Ambulatory time after self-admin | 0.1 | 0.1 | 0.2 | -0.3 | -0.4 | 0.0 | -0.4 | -0.2 | -0.2 |
| Time >=10cm from walls, locomotor time 2 | 0.1 | 0.1 | 0.3 | -0.5 | -0.5 | 0.0 | 0.1 | -0.5 | -0.1 |
| Distance moved, locomotor task time 2 | 0.1 | 0.1 | 0.2 | -0.4 | -0.3 | 0.0 | -0.3 | -0.3 | -0.4 |
| Co content in liver | 0.1 | 0.1 | 0.2 | -0.5 | -0.4 | 0.0 | 0.0 | -0.2 | -0.3 |
| Rb content in liver | 0.1 | 0.1 | 0.6 | -0.1 | -0.1 | 0.0 | -0.4 | -0.2 | -0.8 |
| Length without tail | 0.0 | 0.0 | 0.0 | 0.2 | -0.1 | 0.0 | 0.1 | 0.0 | -0.2 |
| Indifference point AUC | 0.0 | 0.0 | 0.1 | 0.1 | 0.1 | 0.0 | 0.3 | 0.1 | 0.2 |
| Reaction time number correct | 0.0 | 0.0 | 0.0 | -0.1 | 0.1 | 0.0 | -0.0 | 0.1 | 0.1 |
| Reaction time mean minus median | 0.0 | 0.0 | 0.1 | 0.3 | 0.3 | 0.0 | -0.0 | 0.1 | -0.2 |
| Reaction time mean minus median AUC | 0.0 | 0.1 | 0.2 | -0.1 | 0.0 | 0.0 | -0.3 | -0.3 | -0.4 |
| Reaction time trials correct on left | 0.0 | 0.0 | 0.0 | -0.1 | 0.1 | 0.0 | -0.0 | 0.1 | 0.1 |
| Reaction time trials on left | 0.0 | 0.0 | 0.0 | -0.1 | 0.1 | 0.0 | -0.1 | 0.1 | 0.0 |
| Reaction time trials completed | 0.0 | 0.0 | 0.0 | -0.1 | 0.1 | 0.0 | -0.1 | 0.1 | 0.0 |
| Reaction time trials AUC | 0.0 | 0.0 | 0.1 | 0.1 | 0.3 | 0.0 | 0.1 | 0.2 | 0.2 |
| Cocaine response after cond. not corrected | 0.0 | 0.0 | 0.1 | 0.0 | -0.3 | 0.0 | -0.2 | -0.3 | -0.1 |
| Saline control response | 0.0 | 0.0 | 0.1 | 0.3 | 0.2 | 0.0 | 0.1 | 0.2 | -0.3 |
| Conditioned reinforcement - inactives | 0.0 | 0.0 | 0.2 | -0.1 | -0.2 | 0.0 | -0.4 | -0.1 | -0.1 |
| Intermitt. access escalation Index | 0.0 | 0.0 | 0.1 | 0.1 | 0.3 | 0.0 | -0.0 | 0.1 | 0.1 |
| Intermittent access standard deviation | 0.0 | 0.0 | 0.2 | 0.2 | -0.1 | 0.0 | -0.4 | 0.2 | 0.0 |
| Post-drug Anxiety | 0.0 | 0.0 | 0.1 | 0.2 | 0.1 | 0.0 | 0.1 | 0.3 | -0.1 |
| Progressive ratio test 1 active lever presses | 0.0 | 0.0 | 0.1 | -0.3 | -0.2 | 0.0 | -0.1 | -0.2 | 0.0 |
| Progressive ratio test 1 breakpoint | 0.0 | 0.0 | 0.1 | -0.2 | -0.1 | 0.0 | 0.1 | -0.2 | 0.2 |
| Progressive ratio test 1 inactive lever presses | 0.0 | 0.0 | 0.1 | -0.1 | -0.1 | 0.0 | -0.4 | -0.1 | -0.2 |
| Compulsive drug intake | 0.0 | 0.0 | 0.0 | 0.1 | 0.0 | 0.0 | -0.1 | 0.1 | 0.2 |
| Locomotion distance, session 2 | 0.0 | 0.0 | 0.0 | 0.1 | 0.0 | 0.0 | -0.1 | 0.1 | -0.2 |
| Stereotopy head waving duration, day 3 | 0.0 | 0.0 | 0.1 | 0.2 | 0.1 | 0.0 | -0.2 | 0.3 | -0.2 |
| Condit. Reinf. inactive responses | 0.0 | 0.1 | 0.2 | -0.0 | 0.3 | 0.0 | 0.3 | 0.1 | 0.4 |
| Time in familiar zone, hab. session 1 | 0.0 | 0.0 | 0.0 | -0.2 | -0.1 | 0.0 | 0.0 | -0.2 | 0.1 |
| Time in novel zone, hab. session 2 | 0.0 | 0.0 | 0.0 | 0.0 | -0.0 | 0.0 | 0.0 | -0.2 | 0.1 |
| Novelty place preference | 0.0 | 0.0 | 0.0 | 0.2 | 0.2 | 0.0 | 0.1 | 0.1 | 0.1 |
| Time in novel zone, NPP test | 0.0 | 0.0 | 0.1 | -0.1 | -0.0 | 0.0 | -0.2 | -0.2 | -0.2 |
| Bone: elastic displacement | 0.0 | 0.0 | 0.0 | -0.1 | -0.1 | 0.0 | -0.1 | -0.2 | -0.1 |
| Bone: endosteal estimation | 0.0 | 0.1 | 0.1 | -0.2 | 0.2 | 0.0 | -0.3 | -0.2 | -0.3 |
| Bone: marrow area | 0.0 | 0.0 | 0.1 | -0.1 | 0.3 | 0.0 | -0.2 | -0.1 | -0.2 |
| Bone: periosteal estimation | 0.0 | 0.1 | 0.2 | -0.4 | 0.1 | 0.0 | -0.3 | -0.5 | -0.3 |
| Bone: stiffness | 0.0 | 0.0 | 0.2 | -0.0 | 0.1 | 0.0 | 0.1 | -0.5 | 0.1 |
| Extinction: sum of active levers before priming | 0.0 | 0.0 | 0.0 | 0.2 | -0.1 | 0.0 | 0.1 | 0.1 | -0.1 |
| Total heroin consumption | 0.0 | 0.1 | 0.2 | -0.1 | -0.4 | 0.0 | -0.1 | -0.2 | -0.3 |
| Delay disc. indifference point, 0s delay | 0.0 | 0.0 | 0.1 | -0.1 | -0.1 | 0.0 | -0.3 | -0.1 | -0.2 |
| Vertical activity count, locomotor time 2 | 0.0 | 0.0 | 0.1 | 0.1 | 0.2 | 0.0 | 0.1 | 0.1 | -0.1 |
| Seeking ratio, delayed vs. immediate footshock | 0.0 | 0.0 | 0.0 | 0.1 | -0.0 | 0.0 | -0.1 | -0.1 | 0.1 |
| Latency to leave start box in cocaine runway, M | 0.0 | 0.0 | 0.1 | 0.3 | 0.1 | 0.0 | -0.2 | 0.3 | 0.1 |
| Mn content in liver | 0.0 | 0.0 | 0.1 | -0.2 | -0.3 | 0.0 | -0.2 | -0.2 | 0.2 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.