Hub : Genes

Eif3m

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	ENSRNOG00000012738	0.03	0.03	2.1e-03	0.01	0.01	0.01	0.01	8.4e-03	1.1e-02	2.2e-02	2.4e-02
2	BLA	gene expression	ENSRNOG00000012738	0.1	0.09	1.5e-04	0.08	0.07	0.07	0.06	3.5e-05	2.0e-04	1.2e-04	2.2e-04
3	Brain	isoform ratio	ENSRNOT00000017409	0.05	0.05	5.6e-05	0.04	0.04	0.03	0.04	1.1e-04	1.1e-04	1.4e-03	1.6e-04
4	IL	isoform ratio	ENSRNOT00000017409	0.15	0.13	2.6e-03	0.03	0.12	0.02	0.04	7.9e-02	8.5e-04	9.3e-02	5.0e-02
5	Liver	isoform ratio	ENSRNOT00000017409	0.12	0.11	2.1e-11	0.09	0.07	0.07	0.09	8.7e-10	1.4e-08	2.5e-08	8.5e-10
6	Liver	isoform ratio	ENSRNOT00000117477	0.02	0.02	7.5e-03	0.01	0	0	0	3.0e-02	8.1e-02	1.4e-01	8.0e-02
7	Liver	isoform ratio	ENSRNOT00000117946	0.12	0.1	1.1e-12	0.1	0.1	0.09	0.09	8.9e-11	1.2e-10	3.2e-10	2.0e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
BMI with tail	0.3	1.1	1.2	-1.1	-1.0	-1.0	-1.0	-1.0	-1.1	1.0
BMI without tail	0.3	0.7	0.7	-0.9	-0.8	-0.8	-0.8	-0.8	-0.9	0.8
Body weight	1.0	4.1	4.5	-2.1	-2.0	-2.0	-2.0	-1.9	-2.1	1.9
Epididymis fat weight	1.5	3.5	3.7	-1.9	-1.8	-1.9	-1.9	-1.9	-1.9	1.9
Glucose	1.1	1.7	1.8	-1.3	-1.2	-1.3	-1.3	-1.3	-1.3	1.3
Heart weight	0.4	0.5	0.7	0.8	0.6	0.7	0.7	0.7	0.8	-0.7
Left kidney weight	1.0	2.9	2.9	-1.7	-1.7	-1.7	-1.7	-1.7	-1.7	1.7
Right kidney weight	0.9	2.5	2.8	-1.7	-1.5	-1.6	-1.6	-1.5	-1.7	1.5
Tail length	0.1	0.4	0.4	-0.7	-0.6	-0.6	-0.6	-0.6	-0.7	0.6
Length with tail	0.4	1.6	1.8	-1.3	-1.2	-1.3	-1.3	-1.2	-1.3	1.2
Length without tail	0.8	1.7	1.9	-1.3	-1.3	-1.4	-1.4	-1.2	-1.3	1.2
Liver weight, left	0.7	1.2	1.3	-1.1	-1.0	-1.1	-1.1	-1.1	-1.1	1.1
Liver weight, right	2.6	4.3	4.7	-2.2	-1.9	-2.1	-2.1	-2.0	-2.2	2.0
Parametrial fat weight	0.1	0.2	0.4	-0.5	-0.6	-0.5	-0.5	-0.4	-0.5	0.4
Retroperitoneal fat weight	15.6	51.5	52.1	-7.2	-7.2	-7.2	-7.2	-7.1	-7.2	7.1
Intraocular pressure	0.2	0.3	0.4	0.6	0.4	0.6	0.6	0.4	0.6	-0.4
Extensor digitorum longus weight	0.2	0.7	1.1	0.7	1.0	0.8	0.8	0.9	0.7	-0.9
Soleus weight	0.4	1.1	1.3	1.1	1.0	1.1	1.1	1.0	1.1	-1.0
Tibialis anterior weight	1.6	5.7	6.0	2.4	2.4	2.4	2.4	2.3	2.4	-2.3
Tibia length	0.1	0.2	0.4	0.4	0.6	0.5	0.5	0.5	0.4	-0.5
Number of licking bursts	0.4	0.4	0.5	-0.7	-0.6	-0.7	-0.7	-0.7	-0.7	0.7
Food consumed during 24 hour testing period	3.6	4.3	4.5	-2.1	-1.9	-2.1	-2.1	-2.1	-2.1	2.1
Times rat made contact with spout	0.3	0.3	0.3	-0.6	-0.6	-0.6	-0.6	-0.6	-0.6	0.6
Mean time between licks in bursts	0.1	0.2	0.2	0.5	0.4	0.5	0.5	0.4	0.5	-0.4
Mean num. licks in bursts	0.0	0.0	0.1	0.2	0.1	0.2	0.2	0.2	0.2	-0.2
Std. dev. time between licks in bursts	0.6	0.7	0.8	-0.8	-0.8	-0.9	-0.9	-0.9	-0.8	0.9
Water consumed over 24 hours	0.6	0.7	1.1	-0.7	-1.0	-0.8	-0.8	-0.9	-0.7	0.9
Indifference point 0 sec	0.0	0.0	0.1	-0.0	0.3	-0.0	-0.0	0.1	-0.0	-0.1
Indifference point AUC	1.1	1.3	1.5	1.2	1.1	1.2	1.2	1.0	1.2	-1.0
Indifference point function ln k	0.5	0.7	1.0	-1.0	-0.7	-0.9	-0.9	-0.8	-1.0	0.8
Indifference point function log k	0.5	0.7	1.0	-1.0	-0.7	-0.9	-0.9	-0.8	-1.0	0.8
Delay discounting total patch changes 0 sec	0.0	0.0	0.0	-0.0	0.2	-0.0	-0.0	0.0	-0.0	-0.0
Delay discounting total patch changes 12 sec	0.4	0.5	0.6	-0.7	-0.6	-0.7	-0.7	-0.7	-0.7	0.7
Delay discounting total patch changes 18 sec	0.0	0.0	0.0	0.2	0.2	0.1	0.1	-0.0	0.2	0.0
Delay discounting total patch changes 24 sec	0.0	0.0	0.0	0.1	0.2	0.1	0.1	-0.0	0.1	0.0
Delay discounting total patch changes 6 sec	0.0	0.0	0.1	0.1	0.3	0.1	0.1	0.0	0.1	-0.0
Delay discounting time to switch 0 sec	0.4	0.7	0.7	-0.8	-0.8	-0.8	-0.9	-0.8	-0.8	0.8
Delay discounting water rate 0 sec	0.0	0.0	0.0	0.0	0.1	0.1	0.1	0.0	0.0	-0.0
Delay discounting water rate 12 sec	0.0	0.1	0.2	0.2	0.4	0.2	0.2	0.2	0.2	-0.2
Delay discounting water rate 18 sec	0.4	0.5	0.5	-0.7	-0.7	-0.7	-0.7	-0.6	-0.7	0.6
Delay discounting water rate 24 sec	0.0	0.1	0.1	-0.3	-0.2	-0.2	-0.2	-0.2	-0.3	0.2
Delay discounting water rate 6 sec	0.1	0.1	0.1	0.3	0.3	0.3	0.3	0.2	0.3	-0.2
Locomotor activity	0.0	0.0	0.1	0.1	0.2	0.1	0.1	0.1	0.1	-0.1
Locomotor testing distance	1.4	2.3	2.4	-1.5	-1.4	-1.5	-1.5	-1.5	-1.5	1.5
Locomotor testing rearing	0.5	0.8	1.2	-0.8	-1.1	-0.9	-0.9	-0.9	-0.8	0.9
Light reinforcement 1	0.0	0.1	0.2	-0.3	-0.4	-0.3	-0.3	-0.2	-0.3	0.2
Light reinforcement 2	0.7	1.0	1.1	0.9	0.9	1.0	1.0	1.0	0.9	-1.0
Reaction time number correct	0.3	0.4	0.7	0.5	0.8	0.6	0.6	0.6	0.5	-0.6
Reaction time mean minus median	0.1	0.1	0.1	0.3	0.3	0.3	0.3	0.3	0.3	-0.3
Reaction time mean minus median AUC	0.0	0.1	0.1	0.2	0.2	0.3	0.3	0.2	0.2	-0.2
Reaction time num false alarms	2.1	2.9	3.4	1.6	1.5	1.7	1.7	1.9	1.6	-1.9
Reaction time num false alarms AUC	3.1	4.4	5.1	2.0	2.0	2.1	2.1	2.3	2.0	-2.3
Reaction time trials correct on left	0.3	0.4	0.7	0.5	0.8	0.6	0.6	0.6	0.5	-0.6
Reaction time trials on left	0.3	0.5	0.8	0.6	0.9	0.6	0.6	0.7	0.6	-0.7
Reaction time mean	0.1	0.2	0.3	-0.4	-0.5	-0.4	-0.4	-0.4	-0.4	0.4
Reaction time mean AUC	0.2	0.3	0.4	-0.5	-0.6	-0.5	-0.5	-0.6	-0.5	0.6
Median of all reaction times	0.4	0.5	0.7	-0.6	-0.8	-0.7	-0.7	-0.7	-0.6	0.7
Reaction time omissions	0.2	0.3	0.4	0.6	0.4	0.6	0.6	0.6	0.6	-0.6
Reaction time false alarm rate	2.4	3.4	3.9	1.8	1.7	1.9	1.9	2.0	1.8	-2.0
Reaction time premature initiation rate	0.0	0.0	0.0	0.0	-0.1	-0.0	-0.0	0.1	0.0	-0.1
Reaction time premature initiations	0.1	0.1	0.2	0.3	0.4	0.4	0.3	0.5	0.3	-0.5
Std. dev. reaction times	0.0	0.0	0.0	0.1	0.0	0.1	0.1	0.1	0.1	-0.1
Reaction time trials completed	0.3	0.5	0.8	0.6	0.9	0.6	0.6	0.7	0.6	-0.7
Reaction time trials AUC	0.2	0.2	0.5	0.4	0.7	0.4	0.4	0.5	0.4	-0.5
Social response proportion	4.4	4.8	5.0	2.2	2.2	2.2	2.2	2.1	2.2	-2.1
Social responses	0.6	0.7	0.9	1.0	0.8	0.9	0.9	0.8	1.0	-0.8
Social time	7.4	9.7	10.2	3.2	3.0	3.1	3.1	3.1	3.2	-3.1
Conditioned locomotion	5.6	6.6	7.0	2.5	2.6	2.6	2.6	2.6	2.5	-2.6
Cocaine response after cond. corrected	4.0	4.4	4.7	2.1	2.2	2.1	2.1	2.1	2.1	-2.1
Cocaine response after cond. not corrected	1.1	1.2	1.5	1.1	1.2	1.1	1.1	1.1	1.1	-1.1
Cocaine response before conditioning	6.2	7.6	8.3	-2.7	-2.6	-2.8	-2.8	-2.9	-2.7	2.9
Saline control response	0.1	0.1	0.2	-0.4	-0.2	-0.3	-0.4	-0.3	-0.4	0.3
Condit. Reinf. active minus inactive responses	2.3	2.9	3.4	-1.7	-1.8	-1.7	-1.7	-1.6	-1.7	1.6
Condit. Reinf. active-inactive response ratio	5.7	5.9	6.6	-2.5	-2.6	-2.4	-2.4	-2.4	-2.5	2.4
Condit. Reinf. active responses	1.5	2.1	2.3	-1.5	-1.5	-1.4	-1.4	-1.4	-1.5	1.4
Condit. Reinf. inactive responses	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.0
Condit. Reinf. lever presses	1.5	2.0	2.1	-1.4	-1.4	-1.4	-1.4	-1.4	-1.4	1.4
Condit. Reinf. lever reinforcers received	1.6	2.3	2.6	-1.5	-1.6	-1.5	-1.5	-1.5	-1.5	1.5
Pavlov. Cond. lever latency	1.9	2.6	3.0	1.5	1.7	1.6	1.6	1.7	1.5	-1.7
Pavlov. Cond. magazine entry latency	1.2	1.4	2.0	-1.1	-1.4	-1.2	-1.2	-1.2	-1.1	1.2
Pavlov. Cond. change in total contacts	0.4	0.5	0.9	-0.6	-0.9	-0.7	-0.7	-0.7	-0.6	0.7
Pavlov. Cond. index score	1.9	2.5	3.2	-1.5	-1.8	-1.6	-1.6	-1.6	-1.5	1.6
Pavlov. Cond. latency score	1.8	2.3	2.8	-1.4	-1.7	-1.5	-1.5	-1.5	-1.4	1.5
Pavlov. Cond. lever contacts	2.6	3.6	4.1	-1.8	-2.0	-1.9	-1.9	-1.9	-1.8	1.9
Pavlov. Cond. magazine entry number	1.0	1.2	1.7	1.0	1.3	1.1	1.1	1.1	1.0	-1.1
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	-0.2	-0.0	-0.2	-0.2	-0.1	-0.2	0.1
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.3	2.9	-1.4	-1.7	-1.5	-1.5	-1.5	-1.4	1.5
Pavlov. Cond. response bias	2.7	3.7	4.6	-1.8	-2.2	-1.9	-1.9	-1.9	-1.8	1.9
Conditioned reinforcement - actives	8.3	8.1	8.4	-2.9	-2.9	-2.8	-2.8	-2.9	-2.9	2.9
Conditioned reinforcement - inactives	15.6	17.7	18.3	-4.1	-4.3	-4.2	-4.2	-4.2	-4.1	4.2
Conditioned locomotion	5.2	6.2	6.5	-2.5	-2.6	-2.5	-2.5	-2.5	-2.5	2.5
Intermittent access intake day 1-15 change	1.0	1.0	1.0	-1.0	-1.0	-1.0	-1.0	-1.0	-1.0	1.0
Intermittent access intake escalation	1.1	1.1	1.1	-1.1	-1.0	-1.0	-1.0	-1.0	-1.1	1.0
Intermittent access intake escalation 2	1.2	1.2	1.2	-1.1	-1.1	-1.1	-1.1	-1.1	-1.1	1.1
Intermitt. access day 1 inactive lever presses	3.2	3.5	3.7	-1.8	-1.9	-1.9	-1.9	-1.8	-1.8	1.8
Intermitt. access day 15 inactive lever presses	5.0	5.5	5.9	-2.3	-2.4	-2.3	-2.3	-2.4	-2.3	2.4
Intermitt. access escalation Index	0.4	0.4	0.5	0.5	0.7	0.6	0.6	0.7	0.5	-0.7
Intermittent access day 1 total infusions	3.3	3.7	3.8	-1.9	-2.0	-1.9	-1.9	-1.9	-1.9	1.9
Intermittent access day 15 total infusions	5.2	5.8	5.9	-2.4	-2.4	-2.4	-2.4	-2.4	-2.4	2.4
Intermittent access terminal intake (last 3 days)	5.1	5.5	6.0	-2.5	-2.3	-2.3	-2.3	-2.3	-2.5	2.3
Intermittent access total infusions	5.2	5.7	5.9	-2.4	-2.4	-2.4	-2.4	-2.4	-2.4	2.4
Intermittent access day 1 locomotion	2.6	2.7	2.8	-1.7	-1.7	-1.6	-1.6	-1.6	-1.7	1.6
Intermittent access day 15 total locomotion	1.1	1.2	1.4	-1.1	-1.2	-1.1	-1.1	-1.1	-1.1	1.1
Intermittent access total locomotion	3.3	3.8	4.1	-1.9	-2.0	-1.9	-1.9	-1.9	-1.9	1.9
Intermittent access standard deviation	2.9	3.0	3.1	-1.7	-1.7	-1.7	-1.7	-1.8	-1.7	1.8
Cocaine induced anxiety	2.7	3.1	3.3	-1.8	-1.8	-1.7	-1.8	-1.8	-1.8	1.8
Post-drug Anxiety	0.5	0.6	0.7	-0.9	-0.7	-0.7	-0.7	-0.7	-0.9	0.7
Baseline Anxiety	5.7	6.0	6.1	2.5	2.4	2.4	2.4	2.4	2.5	-2.4
Lifetime Intake	4.9	5.5	5.6	-2.3	-2.4	-2.3	-2.3	-2.4	-2.3	2.4
Incentive Sensitization - Responses	1.7	1.7	1.8	-1.3	-1.3	-1.3	-1.3	-1.3	-1.3	1.3
Incentive Sensitization - Breakpoint	1.5	1.5	1.6	-1.2	-1.2	-1.2	-1.2	-1.2	-1.2	1.2
Progressive ratio test 1 active lever presses	3.0	3.1	3.2	-1.7	-1.8	-1.7	-1.7	-1.8	-1.7	1.8
Progressive ratio test 1 breakpoint	2.6	2.7	2.7	-1.7	-1.7	-1.6	-1.6	-1.7	-1.7	1.7
Progressive ratio test 1 inactive lever presses	3.9	4.2	4.5	-2.0	-2.1	-2.0	-2.0	-2.1	-2.0	2.1
Progressive ratio test 2 active lever presses	4.0	4.2	4.4	-2.0	-2.1	-2.0	-2.0	-2.1	-2.0	2.1
Progressive ratio test 2 breakpoint	4.7	5.2	5.4	-2.3	-2.3	-2.3	-2.3	-2.3	-2.3	2.3
Progressive ratio test 2 inactive lever presses	7.9	9.2	9.8	-3.0	-3.1	-3.0	-3.0	-3.0	-3.0	3.0
Total sessions with >9 infusions	2.5	2.8	3.0	-1.7	-1.6	-1.6	-1.6	-1.6	-1.7	1.6
Short access day 1 total inactive lever presses	1.0	1.1	1.2	-1.1	-1.1	-1.1	-1.1	-1.0	-1.1	1.0
Short access day 10 total inactive lever presses	0.5	0.5	0.6	-0.8	-0.8	-0.7	-0.7	-0.7	-0.8	0.7
Short access day 1 total infusions	6.0	6.4	6.5	-2.5	-2.5	-2.5	-2.5	-2.6	-2.5	2.6
Short access day 10 total infusions	2.0	2.2	2.3	-1.5	-1.5	-1.4	-1.4	-1.5	-1.5	1.5
Short access total infusions	2.8	3.1	3.2	-1.8	-1.8	-1.7	-1.7	-1.8	-1.8	1.8
Short access day 1 locomotion	0.5	0.6	0.6	-0.7	-0.7	-0.8	-0.8	-0.8	-0.7	0.8
Short access day 10 total locomotion	2.2	2.4	2.5	-1.6	-1.5	-1.5	-1.5	-1.5	-1.6	1.5
Short access total locomotion	1.3	1.4	1.4	-1.2	-1.1	-1.2	-1.2	-1.1	-1.2	1.1
Compulsive drug intake	2.5	2.4	2.5	1.6	1.5	1.6	1.6	1.6	1.6	-1.6
One hour access (0.3 mA shock)	4.0	4.7	4.9	-2.2	-2.2	-2.1	-2.1	-2.2	-2.2	2.2
One hour access (shock baseline)	6.7	7.7	8.0	-2.7	-2.8	-2.8	-2.8	-2.8	-2.7	2.8
Number of responses in last shaping day	2.3	2.3	2.6	-1.4	-1.6	-1.6	-1.5	-1.6	-1.4	1.6
Context. condit. distance diff. score	4.5	5.4	5.6	-2.3	-2.3	-2.3	-2.3	-2.4	-2.3	2.4
Locomotion velocity, session 1	1.8	1.9	2.0	1.4	1.3	1.4	1.4	1.4	1.4	-1.4
Locomotion distance, session 1	0.2	0.2	0.2	0.5	0.4	0.5	0.5	0.5	0.5	-0.5
Locomotion velocity, session 2	0.0	0.0	0.0	-0.1	0.0	0.0	-0.0	0.1	-0.1	-0.1
Locomotion distance, session 2	0.0	0.0	0.0	0.1	-0.1	0.1	0.1	0.0	0.1	-0.0
Locomotion velocity, session 3	0.1	0.1	0.2	-0.3	-0.3	-0.4	-0.3	-0.4	-0.3	0.4
Locomotion distance, session 3	0.1	0.1	0.1	-0.3	-0.1	-0.3	-0.3	-0.3	-0.3	0.3
Stereotopy head waving bouts, day 3	0.1	0.1	0.1	0.4	0.3	0.3	0.4	0.3	0.4	-0.3
Stereotopy head waving duration, day 3	0.2	0.3	0.4	-0.5	-0.6	-0.5	-0.5	-0.6	-0.5	0.6
Locomotion velocity, session 7	0.1	0.1	0.1	-0.3	-0.1	-0.3	-0.3	-0.2	-0.3	0.2
Locomotion distance, session 7	0.1	0.2	0.2	0.4	0.4	0.4	0.4	0.4	0.4	-0.4
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	-0.0	-0.1	-0.1	-0.1	-0.1	-0.0	0.1
Stereotopy head waving duration, day 7	0.0	0.0	0.0	0.2	0.1	0.2	0.2	0.1	0.2	-0.1
Locomotion velocity, session 8	0.2	0.2	0.4	-0.5	-0.6	-0.5	-0.5	-0.5	-0.5	0.5
Locomotion distance, session 8	2.7	4.1	4.4	-1.9	-2.1	-2.0	-2.0	-2.1	-1.9	2.1
Degree of sensitization distance	0.4	0.4	0.4	0.6	0.5	0.6	0.6	0.7	0.6	-0.7
Degree of sensitization stereotypy	0.2	0.2	0.2	0.5	0.4	0.5	0.5	0.4	0.5	-0.4
Condit. Reinf. active minus inactive responses	2.5	2.8	3.0	-1.6	-1.7	-1.7	-1.7	-1.7	-1.6	1.7
Condit. Reinf. active-inactive response ratio	7.0	7.5	8.0	-2.6	-2.7	-2.7	-2.7	-2.8	-2.6	2.8
Condit. Reinf. active responses	0.4	0.4	0.6	-0.6	-0.7	-0.7	-0.7	-0.7	-0.6	0.7
Condit. Reinf. inactive responses	2.4	2.8	2.8	1.7	1.6	1.7	1.7	1.7	1.7	-1.7
Incentive salience index mean	1.6	1.9	2.1	-1.3	-1.4	-1.4	-1.4	-1.4	-1.3	1.4
Condit. Reinf. lever presses	0.5	0.6	0.7	-0.7	-0.9	-0.8	-0.8	-0.8	-0.7	0.8
Time in familiar zone, hab. session 1	1.2	1.1	1.2	1.0	1.1	1.1	1.1	1.1	1.0	-1.1
Time in novel zone, hab. session 1	2.1	2.0	2.1	-1.4	-1.4	-1.4	-1.4	-1.4	-1.4	1.4
Total zone transitions, hab. session 1	2.0	2.8	3.1	-1.6	-1.8	-1.7	-1.7	-1.7	-1.6	1.7
Total locomotion distance, hab. session 1	0.4	0.6	0.8	-0.8	-0.9	-0.8	-0.8	-0.8	-0.8	0.8
Locomotion velocity, hab. session 1	0.3	0.4	0.5	-0.6	-0.7	-0.7	-0.7	-0.7	-0.6	0.7
Time in familiar zone, hab. session 2	0.2	0.2	0.2	0.4	0.4	0.5	0.5	0.5	0.4	-0.5
Time in novel zone, hab. session 2	0.2	0.2	0.2	-0.4	-0.3	-0.4	-0.4	-0.4	-0.4	0.4
Total zone transitions, hab. session 2	0.5	0.6	0.7	-0.7	-0.8	-0.8	-0.8	-0.8	-0.7	0.8
Total locomotion distance, hab. session 2	0.4	0.5	0.6	0.7	0.7	0.7	0.7	0.7	0.7	-0.7
Locomotion velocity, hab. session 2	0.3	0.4	0.4	0.6	0.6	0.6	0.6	0.6	0.6	-0.6
Novel to familiar place preference ratio	3.3	3.5	3.6	-1.9	-1.8	-1.9	-1.9	-1.9	-1.9	1.9
Novelty place preference	3.7	3.8	3.9	-2.0	-1.9	-2.0	-2.0	-1.9	-2.0	1.9
Time in novel zone, NPP test	3.0	3.1	3.2	-1.8	-1.7	-1.8	-1.8	-1.8	-1.8	1.8
Total zone transitions, NPP test	1.7	2.4	2.6	1.6	1.5	1.6	1.6	1.5	1.6	-1.5
Total locomotion distance, NPP test	2.2	3.0	3.1	1.8	1.7	1.7	1.8	1.7	1.8	-1.7
Locomotion velocity, NPP test	1.9	2.7	2.7	1.7	1.6	1.6	1.6	1.6	1.7	-1.6
Pavlov. Cond. lever latency	0.3	0.4	0.5	0.5	0.7	0.6	0.6	0.7	0.5	-0.7
Pavlov. Cond. magazine entry latency	1.1	1.4	1.6	-1.1	-1.2	-1.2	-1.2	-1.2	-1.1	1.2
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.2	0.1	0.2	0.2	0.1	0.2	-0.1
Pavlov. Cond. index score	0.1	0.2	0.2	-0.3	-0.5	-0.4	-0.4	-0.5	-0.3	0.5
Pavlov. Cond. latency score	0.2	0.3	0.3	-0.4	-0.5	-0.5	-0.5	-0.6	-0.4	0.6
Pavlov. Cond. lever contacts	0.2	0.2	0.3	-0.4	-0.5	-0.5	-0.5	-0.5	-0.4	0.5
Pavlov. Cond. magazine entry number	1.3	1.6	1.7	1.2	1.2	1.3	1.2	1.3	1.2	-1.3
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	-0.3	-0.3	-0.2	-0.2	-0.2	-0.3	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.1	0.1	-0.2	-0.3	-0.2	-0.2	-0.3	-0.2	0.3
Pavlov. Cond. response bias	0.5	0.6	0.7	-0.7	-0.8	-0.8	-0.8	-0.9	-0.7	0.9
Bone: apparent density	0.6	1.1	1.4	-0.8	-1.2	-1.0	-1.0	-1.2	-0.8	1.2
Bone surface	0.3	0.6	0.8	-0.6	-0.9	-0.7	-0.7	-0.9	-0.6	0.9
Bone volume	0.8	1.4	1.7	-1.0	-1.3	-1.1	-1.1	-1.3	-1.0	1.3
Bone: connectivity density	0.7	1.1	1.5	-0.8	-1.2	-1.0	-1.0	-1.2	-0.8	1.2
Bone: cortical apparent density	0.0	0.0	0.0	0.0	-0.2	-0.1	-0.1	-0.1	0.0	0.1
Bone: cortical area	0.4	0.7	0.8	-0.9	-0.7	-0.9	-0.9	-0.8	-0.9	0.8
Bone: cortical porosity	0.7	0.8	0.9	0.8	0.8	0.9	0.9	1.0	0.8	-1.0
Bone: cortical porosity	0.1	0.2	0.2	0.3	0.3	0.4	0.4	0.5	0.3	-0.5
Bone: cortical thickness	0.0	0.0	0.0	-0.2	-0.1	-0.2	-0.2	-0.2	-0.2	0.2
Bone: cortical thickness	1.2	1.4	1.6	1.2	1.3	1.2	1.2	1.2	1.2	-1.2
Bone: cortical tissue density	0.0	0.0	0.0	-0.0	-0.2	-0.1	-0.1	-0.1	-0.0	0.1
Bone: elastic displacement	0.6	0.7	0.8	0.9	0.7	0.9	0.9	0.8	0.9	-0.8
Bone: elastic work	0.0	0.0	0.0	-0.0	0.1	0.0	0.0	-0.1	-0.0	0.1
Bone: endosteal estimation	0.0	0.1	0.2	0.2	0.4	0.3	0.3	0.4	0.2	-0.4
Bone: endosteal perimeter	0.2	0.4	0.5	-0.7	-0.4	-0.7	-0.7	-0.5	-0.7	0.5
Bone: final force	0.1	0.2	0.3	-0.5	-0.2	-0.5	-0.5	-0.5	-0.5	0.5
Bone: final moment	0.0	0.1	0.1	-0.3	-0.0	-0.2	-0.3	-0.2	-0.3	0.2
Bone: marrow area	0.0	0.1	0.2	0.2	0.4	0.3	0.3	0.4	0.2	-0.4
Bone: maximum diameter	0.2	0.3	0.4	-0.7	-0.4	-0.6	-0.6	-0.5	-0.7	0.5
Bone: maximum force	0.4	0.6	0.8	-0.9	-0.5	-0.8	-0.8	-0.8	-0.9	0.8
Bone: maximum moment	0.1	0.2	0.4	-0.6	-0.3	-0.5	-0.5	-0.5	-0.6	0.5
Bone: minimum diameter	1.2	2.2	2.4	-1.6	-1.3	-1.5	-1.5	-1.4	-1.6	1.4
Bone: periosteal estimation	0.0	0.0	0.1	-0.3	0.0	-0.2	-0.2	-0.1	-0.3	0.1
Bone: periosteal perimeter	0.5	0.8	1.0	-1.0	-0.6	-0.9	-0.9	-0.8	-1.0	0.8
Bone: post-yield work	0.0	0.0	0.0	0.1	0.0	0.1	0.1	0.1	0.1	-0.1
Bone: stiffness	0.7	1.1	1.5	-1.2	-0.8	-1.1	-1.1	-1.0	-1.2	1.0
Bone: tissue strength	0.5	0.5	0.5	0.7	0.7	0.7	0.7	0.7	0.7	-0.7
Bone: trabecular number	0.7	1.0	1.6	-0.8	-1.2	-1.0	-0.9	-1.1	-0.8	1.1
Bone: trabecular spacing	0.0	0.0	0.1	-0.3	0.1	-0.1	-0.2	0.0	-0.3	-0.0
Bone: trabecular thickness	0.2	0.2	0.4	-0.4	-0.6	-0.4	-0.4	-0.6	-0.4	0.6
Bone: trabecular tissue density	0.7	1.0	1.1	1.0	1.0	1.0	1.0	1.1	1.0	-1.1
Breakpoint value in progressive ratio session	1.2	1.3	1.3	1.2	1.1	1.1	1.1	1.1	1.2	-1.1
Distance traveled before self-admin	0.3	0.3	0.4	-0.7	-0.4	-0.5	-0.5	-0.4	-0.7	0.4
Distance traveled after self-admin	0.9	1.0	1.1	-1.1	-0.9	-1.0	-1.0	-0.9	-1.1	0.9
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	-0.0	-0.2	-0.0	-0.0	0.0	-0.0	-0.0
Delta time in open arm before/after self-admin	1.6	1.6	1.8	1.3	1.3	1.2	1.2	1.2	1.3	-1.2
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1	-0.2	-0.1	0.2
Extinction: sum of active levers before priming	0.0	0.0	0.0	-0.1	-0.2	-0.1	-0.1	-0.1	-0.1	0.1
Active lever presses in extinction session 6	0.6	0.6	0.8	-0.7	-0.9	-0.8	-0.8	-0.7	-0.7	0.7
Delta distance traveled before/after self-admin	0.0	0.0	0.0	-0.0	-0.1	-0.1	-0.1	-0.1	-0.0	0.1
Delta ambulatory time before/after self-admin	0.1	0.2	0.2	-0.4	-0.4	-0.4	-0.4	-0.4	-0.4	0.4
Time in closed arm before self-admin	3.9	4.5	4.9	-2.0	-2.0	-2.1	-2.1	-2.2	-2.0	2.2
Time in closed arm after self-admin	3.3	3.4	3.5	-1.8	-1.9	-1.8	-1.8	-1.9	-1.8	1.9
Time in open arm before self-admin	3.0	3.2	3.4	1.7	1.7	1.8	1.9	1.8	1.7	-1.8
Time in open arm after self-admin	7.4	8.2	8.8	2.8	2.9	2.8	2.8	3.0	2.8	-3.0
Sum of active levers in priming session hrs 5-6	1.3	1.3	1.5	1.1	1.1	1.1	1.1	1.2	1.1	-1.2
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.5	-0.5	-0.7	-0.6	-0.6	-0.6	-0.5	0.6
Time to tail flick, vehicle, after self-admin	3.9	4.2	4.3	-2.1	-2.0	-2.0	-2.0	-2.1	-2.1	2.1
Time to tail flick, test, before self-admin	0.3	0.3	0.4	-0.5	-0.6	-0.6	-0.6	-0.5	-0.5	0.5
Time to tail flick, test, after self-admin	1.1	1.2	1.4	-1.1	-1.2	-1.1	-1.1	-1.0	-1.1	1.0
Delta time to tail flick, vehicle, before/after SA	1.6	1.6	1.7	-1.3	-1.2	-1.3	-1.2	-1.3	-1.3	1.3
Delta time to tail flick, test, before/after SA	0.2	0.1	0.2	0.3	0.4	0.4	0.4	0.4	0.3	-0.4
Ambulatory time before self-admin	0.3	0.3	0.4	-0.6	-0.4	-0.5	-0.5	-0.4	-0.6	0.4
Ambulatory time after self-admin	1.5	1.6	1.8	-1.3	-1.3	-1.3	-1.3	-1.2	-1.3	1.2
Total heroin consumption	0.4	0.4	0.6	0.6	0.8	0.7	0.7	0.7	0.6	-0.7
Area under the delay curve	0.2	0.2	0.3	0.5	0.5	0.6	0.6	0.5	0.5	-0.5
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	-0.1	-0.1	-0.2	-0.2	-0.2	-0.1	0.2
Delay disc. indifference point, 16s delay	0.6	0.6	0.7	0.8	0.8	0.8	0.8	0.7	0.8	-0.7
Delay disc. indifference point, 2s delay	0.2	0.2	0.2	-0.4	-0.5	-0.4	-0.4	-0.5	-0.4	0.5
Delay disc. indifference point, 24s delay	0.4	0.4	0.5	0.7	0.6	0.7	0.7	0.6	0.7	-0.6
Delay disc. indifference point, 4s delay	0.3	0.3	0.4	0.5	0.5	0.6	0.6	0.5	0.5	-0.5
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	-0.1	-0.0	0.1	0.1	-0.0	-0.1	0.0
Delay discount exponential model param	0.3	0.3	0.4	-0.5	-0.5	-0.6	-0.7	-0.5	-0.5	0.5
Delay discount hyperbolic model param	0.2	0.2	0.3	-0.4	-0.4	-0.5	-0.5	-0.4	-0.4	0.4
Fecal boli incidents, locomotor time 1	7.3	8.0	8.7	2.8	3.0	2.8	2.8	2.8	2.8	-2.8
Change in fecal boli incidents, locomotor task	2.0	1.9	2.0	-1.4	-1.4	-1.4	-1.4	-1.4	-1.4	1.4
Time >=10cm from walls, locomotor time 1	1.0	1.0	1.1	1.1	1.0	1.0	1.0	0.8	1.1	-0.8
Bouts of movement, locomotor time 1	0.1	0.1	0.1	0.4	0.2	0.2	0.2	0.1	0.4	-0.1
Total resting periods, locomotor time 1	0.2	0.3	0.4	0.6	0.5	0.5	0.5	0.4	0.6	-0.4
Rest time, locomotor task time 1	2.9	3.2	3.5	1.8	1.9	1.7	1.7	1.8	1.8	-1.8
Distance moved, locomotor task time 1	2.8	3.0	3.2	-1.7	-1.8	-1.7	-1.7	-1.8	-1.7	1.8
Vertical activity count, locomotor time 1	0.6	0.7	0.8	-0.8	-0.9	-0.8	-0.8	-0.8	-0.8	0.8
Time >=10cm from walls, locomotor time 2	2.7	2.9	3.0	-1.7	-1.6	-1.7	-1.7	-1.7	-1.7	1.7
Bouts of movement, locomotor time 2	1.9	2.0	2.2	-1.3	-1.5	-1.4	-1.4	-1.5	-1.3	1.5
Total resting periods, locomotor time 2	1.8	1.9	2.2	-1.3	-1.5	-1.4	-1.4	-1.5	-1.3	1.5
Rest time, locomotor task time 2	3.4	3.9	4.0	2.0	2.0	2.0	2.0	2.0	2.0	-2.0
Distance moved, locomotor task time 2	2.8	3.2	3.3	-1.8	-1.7	-1.8	-1.8	-1.8	-1.8	1.8
Vertical activity count, locomotor time 2	3.3	3.6	3.8	-2.0	-1.9	-1.9	-1.9	-1.8	-2.0	1.8
Weight adjusted by age	0.0	0.0	0.1	0.0	-0.0	0.0	0.0	0.3	0.0	-0.3
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.3	-0.4	-0.5	-0.5	-0.4	-0.6	-0.4	0.6
Locomotion in novel chamber	0.4	0.5	0.6	-0.7	-0.7	-0.7	-0.7	-0.8	-0.7	0.8
Locomotion in novel chamber post-restriction	1.6	1.9	2.2	1.5	1.4	1.4	1.4	1.2	1.5	-1.2
Progressive ratio	0.3	0.3	0.4	-0.6	-0.6	-0.6	-0.6	-0.6	-0.6	0.6
Food seeking constrained by brief footshock	0.3	0.3	0.4	-0.5	-0.6	-0.5	-0.5	-0.6	-0.5	0.6
Seeking ratio, punishment vs. effort	0.3	0.3	0.4	0.6	0.6	0.6	0.6	0.5	0.6	-0.5
Run reversals in cocaine runway, females	2.0	2.0	2.3	-1.4	-1.4	-1.3	-1.3	-1.5	-1.4	1.5
Run reversals in cocaine runway, males	0.0	0.0	0.1	0.3	0.2	0.2	0.2	0.1	0.3	-0.1
Latency to leave start box in cocaine runway	0.5	0.5	0.8	0.6	0.9	0.7	0.7	0.8	0.6	-0.8
Latency to leave start box in cocaine runway, F	0.6	0.7	0.9	0.8	0.9	0.8	0.8	0.9	0.8	-0.9
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	-0.1	0.1	-0.0	-0.0	-0.0	-0.1	0.0
Cd content in liver	0.1	0.1	0.2	-0.4	-0.3	-0.4	-0.4	-0.4	-0.4	0.4
Co content in liver	1.5	1.8	1.9	1.4	1.4	1.3	1.3	1.3	1.4	-1.3
Cu content in liver	1.2	1.5	2.0	1.1	1.4	1.2	1.2	1.2	1.1	-1.2
Fe content in liver	0.2	0.2	0.2	0.4	0.5	0.5	0.5	0.5	0.4	-0.5
K content in liver	0.7	0.7	0.8	0.8	0.9	0.8	0.8	0.9	0.8	-0.9
Mg content in liver	0.7	0.7	0.9	0.8	0.9	0.8	0.8	0.8	0.8	-0.8
Mn content in liver	1.3	1.5	1.6	1.3	1.2	1.2	1.2	1.2	1.3	-1.2
Na content in liver	0.2	0.2	0.2	-0.5	-0.5	-0.5	-0.5	-0.5	-0.5	0.5
Rb content in liver	1.1	1.4	1.6	1.2	1.2	1.1	1.1	1.1	1.2	-1.1
Se content in liver	3.7	4.5	4.8	2.1	2.1	2.1	2.1	2.2	2.1	-2.2
Sr content in liver	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1	-0.1	-0.1	0.1
Zn content in liver	1.5	1.6	1.8	1.3	1.3	1.3	1.3	1.2	1.3	-1.2