Hub : Genes

Grin3b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000012562 0.1 0.06 5.2e-11 0.09 0.09 0.09 0.09 1.6e-10 5.2e-10 5.4e-10 3.4e-10
2 BLA gene expression ENSRNOG00000012562 0.15 0.09 1.3e-07 0.14 0.12 0.13 0.12 4.4e-08 3.6e-07 1.2e-07 3.4e-07
3 Brain gene expression ENSRNOG00000012562 0.29 0.13 0.0e+00 0.18 0.18 0.19 0.19 2.2e-16 1.2e-16 3.7e-17 1.6e-17
4 IL gene expression ENSRNOG00000012562 0.14 0.11 9.0e-03 0.02 0.05 0.02 0.05 1.1e-01 2.1e-02 1.1e-01 2.0e-02
5 LHb gene expression ENSRNOG00000012562 0.34 0.17 2.8e-07 0.23 0.2 0.16 0.21 4.3e-06 2.2e-05 1.1e-04 1.0e-05
6 NAcc gene expression ENSRNOG00000012562 0.16 0.1 1.1e-11 0.15 0.15 0.15 0.15 3.9e-11 2.3e-11 2.1e-11 1.5e-11
7 OFC gene expression ENSRNOG00000012562 0.48 0.19 6.5e-08 0.21 0.23 0.2 0.23 8.9e-06 3.0e-06 2.0e-05 3.7e-06
8 PL gene expression ENSRNOG00000012562 0.2 0.11 6.6e-15 0.19 0.17 0.18 0.18 4.3e-14 2.9e-13 1.7e-13 1.7e-13

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
BMI with tail5.618.221.2-4.5-4.5-4.1-4.6-4.5-4.3-2.7-4.6
BMI without tail1.42.94.6-2.2-1.8-1.6-2.1-1.8-1.5-0.4-1.7
Body weight1.04.25.4-2.3-2.1-2.0-2.3-2.1-1.9-1.2-2.1
Epididymis fat weight0.40.81.00.90.81.00.90.90.90.80.9
Glucose1.42.23.3-1.5-1.6-1.3-1.5-1.6-1.5-0.9-1.8
Heart weight0.30.50.90.70.30.90.80.30.50.90.5
Left kidney weight0.00.00.2-0.10.1-0.3-0.00.10.0-0.40.2
Right kidney weight1.23.44.81.81.91.61.82.01.91.32.2
Tail length3.310.012.02.93.43.13.13.43.32.63.5
Length with tail1.55.47.02.32.52.12.42.52.41.42.7
Length without tail0.00.10.60.10.1-0.30.10.1-0.2-0.80.0
Liver weight, left1.72.73.4-1.8-1.7-1.6-1.8-1.7-1.6-1.0-1.7
Liver weight, right1.42.43.1-1.7-1.4-1.8-1.7-1.4-1.4-1.4-1.4
Parametrial fat weight0.50.91.30.70.91.00.80.91.01.01.1
Retroperitoneal fat weight0.10.40.7-0.8-0.7-0.7-0.8-0.6-0.5-0.2-0.5
Intraocular pressure0.30.42.10.5-0.00.90.4-0.00.41.40.3
Extensor digitorum longus weight3.112.317.1-4.1-3.6-3.4-4.1-3.6-3.2-1.7-3.8
Soleus weight8.123.527.3-5.2-5.1-4.7-5.2-5.1-4.8-3.3-5.0
Tibialis anterior weight0.93.04.4-2.1-1.6-1.9-2.1-1.6-1.6-1.2-1.8
Tibia length0.92.62.91.71.61.61.71.61.61.31.7
Number of licking bursts0.10.20.90.00.10.50.00.10.40.9-0.0
Food consumed during 24 hour testing period0.40.50.7-0.8-0.8-0.6-0.8-0.8-0.5-0.2-0.7
Times rat made contact with spout0.10.10.3-0.3-0.2-0.0-0.3-0.20.10.5-0.4
Mean time between licks in bursts4.25.96.42.52.52.52.52.52.52.12.2
Mean num. licks in bursts0.10.10.2-0.2-0.2-0.4-0.2-0.2-0.3-0.3-0.1
Std. dev. time between licks in bursts0.50.50.80.80.90.60.80.90.80.40.6
Water consumed over 24 hours0.81.01.2-1.0-0.9-1.1-1.0-0.9-0.9-1.1-1.0
Indifference point 0 sec0.20.40.5-0.6-0.6-0.6-0.6-0.5-0.6-0.7-0.7
Indifference point AUC0.70.81.00.90.81.00.90.80.80.81.0
Indifference point function ln k0.10.20.3-0.5-0.5-0.4-0.5-0.5-0.4-0.0-0.5
Indifference point function log k0.10.20.3-0.5-0.5-0.4-0.5-0.5-0.4-0.0-0.5
Delay discounting total patch changes 0 sec0.10.20.3-0.5-0.4-0.4-0.5-0.3-0.4-0.4-0.6
Delay discounting total patch changes 12 sec0.20.20.3-0.6-0.5-0.3-0.6-0.5-0.4-0.0-0.4
Delay discounting total patch changes 18 sec0.91.31.41.11.21.21.21.21.10.81.2
Delay discounting total patch changes 24 sec0.00.00.00.2-0.00.20.20.0-0.0-0.10.1
Delay discounting total patch changes 6 sec0.10.10.20.40.30.40.40.40.30.10.2
Delay discounting time to switch 0 sec1.92.95.7-1.7-1.3-2.1-1.6-1.3-1.6-2.4-1.2
Delay discounting water rate 0 sec0.40.73.10.40.51.00.30.50.81.80.2
Delay discounting water rate 12 sec0.50.71.1-0.8-1.0-0.2-0.9-1.0-0.60.7-1.0
Delay discounting water rate 18 sec1.31.76.70.90.61.60.70.71.22.60.7
Delay discounting water rate 24 sec0.40.53.50.0-0.10.8-0.1-0.10.41.9-0.2
Delay discounting water rate 6 sec0.91.33.81.00.81.50.90.71.12.00.8
Locomotor activity1.72.83.61.81.91.51.91.91.50.31.8
Locomotor testing distance1.11.82.41.51.41.31.61.41.20.41.5
Locomotor testing rearing0.10.10.40.30.20.50.30.20.30.70.2
Light reinforcement 14.58.210.63.23.02.73.33.02.71.53.2
Light reinforcement 21.41.92.91.71.41.31.71.41.20.61.4
Reaction time number correct0.20.20.9-0.4-0.40.0-0.5-0.4-0.01.0-0.5
Reaction time mean minus median0.81.01.21.01.01.10.90.91.01.10.9
Reaction time mean minus median AUC0.10.10.3-0.2-0.0-0.3-0.2-0.1-0.1-0.5-0.1
Reaction time num false alarms0.10.10.7-0.1-0.00.3-0.10.00.20.8-0.2
Reaction time num false alarms AUC0.10.11.0-0.1-0.00.3-0.20.00.21.0-0.2
Reaction time trials correct on left0.20.20.9-0.4-0.40.0-0.5-0.4-0.01.0-0.5
Reaction time trials on left0.20.20.8-0.4-0.4-0.0-0.5-0.4-0.10.9-0.5
Reaction time mean0.10.10.2-0.2-0.3-0.3-0.2-0.4-0.4-0.4-0.3
Reaction time mean AUC0.10.20.3-0.3-0.5-0.4-0.3-0.5-0.5-0.5-0.4
Median of all reaction times0.50.70.8-0.7-0.9-0.9-0.7-0.9-0.9-0.9-0.8
Reaction time omissions0.10.10.20.50.10.30.50.10.10.00.3
Reaction time false alarm rate0.00.00.0-0.2-0.1-0.1-0.1-0.0-0.00.0-0.1
Reaction time premature initiation rate1.21.62.31.31.11.51.31.11.21.41.2
Reaction time premature initiations1.31.84.21.21.01.71.21.01.32.11.0
Std. dev. reaction times0.10.20.20.40.40.50.40.40.40.40.4
Reaction time trials completed0.20.20.8-0.4-0.4-0.0-0.5-0.4-0.10.9-0.5
Reaction time trials AUC0.20.21.3-0.3-0.30.1-0.4-0.30.11.1-0.4
Social response proportion0.30.30.60.70.70.40.80.60.5-0.20.5
Social responses4.96.47.82.72.82.42.82.72.51.32.7
Social time0.81.11.3-1.0-1.1-1.0-1.0-1.1-1.2-1.1-1.1
Conditioned locomotion0.60.81.2-1.0-1.0-0.6-1.0-1.0-0.70.2-1.1
Cocaine response after cond. corrected3.23.65.1-2.1-2.3-1.4-2.2-2.3-1.7-0.2-2.0
Cocaine response after cond. not corrected3.23.55.0-2.2-2.2-1.4-2.2-2.2-1.7-0.1-2.0
Cocaine response before conditioning0.50.60.90.71.00.50.71.00.80.40.8
Saline control response0.00.00.1-0.2-0.2-0.1-0.2-0.2-0.2-0.0-0.3
Condit. Reinf. active minus inactive responses2.53.14.11.91.62.01.81.61.72.01.5
Condit. Reinf. active-inactive response ratio0.30.31.00.5-0.10.90.5-0.10.11.00.0
Condit. Reinf. active responses2.12.93.41.81.71.91.81.71.71.71.5
Condit. Reinf. inactive responses1.31.62.21.21.51.11.21.51.41.11.2
Condit. Reinf. lever presses2.53.54.21.91.72.01.91.71.81.91.8
Condit. Reinf. lever reinforcers received1.82.53.31.61.51.81.61.51.61.81.3
Pavlov. Cond. lever latency0.60.81.0-0.9-0.8-1.0-0.9-0.8-0.9-0.9-0.8
Pavlov. Cond. magazine entry latency0.50.60.80.60.90.60.60.90.90.60.8
Pavlov. Cond. change in total contacts0.50.81.21.00.71.11.00.70.80.90.7
Pavlov. Cond. index score0.71.01.11.01.01.01.01.01.01.00.9
Pavlov. Cond. latency score0.60.70.80.90.80.90.90.80.90.80.8
Pavlov. Cond. lever contacts0.71.01.41.00.91.11.00.91.01.20.9
Pavlov. Cond. magazine entry number0.70.91.2-0.9-1.1-0.8-0.9-1.1-1.1-0.8-1.0
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.4-0.4-0.2-0.4-0.4-0.20.3-0.5
Pavlov. Cond. lever-magazine prob. diff.0.70.91.00.91.01.00.91.01.00.90.9
Pavlov. Cond. response bias1.82.52.91.61.51.71.61.51.61.71.5
Conditioned reinforcement - actives1.71.72.01.41.41.21.41.41.30.91.4
Conditioned reinforcement - inactives0.20.20.3-0.5-0.5-0.4-0.5-0.5-0.40.1-0.5
Conditioned locomotion6.27.48.42.92.82.82.92.92.71.92.9
Intermittent access intake day 1-15 change6.76.67.62.62.82.52.62.62.72.12.6
Intermittent access intake escalation7.57.38.12.72.82.72.72.72.82.72.7
Intermittent access intake escalation 28.88.79.12.92.93.02.92.93.02.82.9
Intermitt. access day 1 inactive lever presses0.30.30.90.50.40.60.40.50.60.90.5
Intermitt. access day 15 inactive lever presses0.70.70.80.80.90.90.80.80.90.80.8
Intermitt. access escalation Index0.60.61.2-0.6-0.6-1.0-0.6-0.6-0.7-1.1-0.6
Intermittent access day 1 total infusions0.10.10.1-0.2-0.4-0.2-0.2-0.2-0.4-0.3-0.2
Intermittent access day 15 total infusions2.32.62.71.61.61.61.61.61.61.51.6
Intermittent access terminal intake (last 3 days)1.01.11.31.11.21.01.11.11.10.91.1
Intermittent access total infusions0.30.30.30.50.50.50.50.50.50.60.5
Intermittent access day 1 locomotion0.50.60.60.80.70.70.80.80.80.70.8
Intermittent access day 15 total locomotion3.73.94.42.12.11.82.12.12.01.62.1
Intermittent access total locomotion0.80.91.11.01.00.81.01.00.90.61.0
Intermittent access standard deviation3.13.33.41.81.81.81.81.81.91.81.8
Cocaine induced anxiety0.10.20.40.40.40.00.40.40.1-0.60.4
Post-drug Anxiety0.20.20.30.50.50.10.50.50.2-0.50.5
Baseline Anxiety0.50.61.20.60.60.80.60.60.81.10.6
Lifetime Intake0.10.10.10.30.30.30.30.30.30.30.3
Incentive Sensitization - Responses0.20.20.50.40.30.50.40.40.40.70.4
Incentive Sensitization - Breakpoint0.20.20.50.50.40.50.50.50.50.70.5
Progressive ratio test 1 active lever presses0.00.00.2-0.00.00.0-0.0-0.00.10.4-0.0
Progressive ratio test 1 breakpoint0.00.00.1-0.1-0.0-0.1-0.2-0.10.10.3-0.1
Progressive ratio test 1 inactive lever presses0.00.00.10.20.20.10.20.20.20.20.2
Progressive ratio test 2 active lever presses0.30.30.70.50.50.60.50.50.60.90.5
Progressive ratio test 2 breakpoint0.30.30.40.50.50.50.50.50.50.60.5
Progressive ratio test 2 inactive lever presses0.00.00.00.10.1-0.00.10.10.0-0.10.1
Total sessions with >9 infusions0.10.10.2-0.3-0.2-0.4-0.3-0.3-0.3-0.5-0.3
Short access day 1 total inactive lever presses0.00.10.10.30.30.10.30.30.20.00.3
Short access day 10 total inactive lever presses0.00.00.0-0.0-0.00.2-0.0-0.00.00.1-0.0
Short access day 1 total infusions0.10.10.20.20.3-0.10.30.20.1-0.40.2
Short access day 10 total infusions0.20.20.50.40.40.40.40.40.50.70.4
Short access total infusions0.00.00.0-0.1-0.0-0.1-0.0-0.1-0.1-0.2-0.1
Short access day 1 locomotion0.60.60.80.90.90.60.90.90.80.20.9
Short access day 10 total locomotion4.14.54.72.12.22.12.12.12.21.92.1
Short access total locomotion0.60.60.90.80.90.70.90.80.80.50.8
Compulsive drug intake1.91.92.1-1.4-1.4-1.3-1.4-1.4-1.4-1.4-1.4
One hour access (0.3 mA shock)0.10.10.1-0.3-0.3-0.2-0.3-0.3-0.3-0.1-0.3
One hour access (shock baseline)0.40.51.10.60.60.70.60.60.71.10.6
Number of responses in last shaping day0.10.10.10.40.30.20.40.40.30.30.4
Context. condit. distance diff. score0.10.10.3-0.6-0.0-0.4-0.5-0.00.00.1-0.0
Locomotion velocity, session 10.10.20.30.50.30.10.50.30.1-0.60.4
Locomotion distance, session 10.40.52.8-0.10.3-0.7-0.10.3-0.2-1.70.3
Locomotion velocity, session 22.52.94.51.72.11.11.82.11.6-0.12.0
Locomotion distance, session 20.50.71.41.00.80.21.00.80.3-1.20.8
Locomotion velocity, session 37.28.49.92.93.12.82.93.13.12.42.9
Locomotion distance, session 30.10.10.2-0.00.30.10.00.30.40.50.1
Stereotopy head waving bouts, day 34.55.47.52.32.72.02.32.72.51.32.4
Stereotopy head waving duration, day 35.66.88.62.72.92.42.72.92.71.72.7
Locomotion velocity, session 71.01.11.80.71.40.80.71.41.30.91.0
Locomotion distance, session 70.10.10.5-0.20.00.1-0.20.00.20.7-0.1
Stereotopy head waving bouts, day 70.10.10.6-0.10.1-0.4-0.10.1-0.2-0.80.0
Stereotopy head waving duration, day 70.10.10.50.20.3-0.20.20.30.0-0.70.2
Locomotion velocity, session 80.40.40.90.41.0-0.10.41.00.5-0.80.5
Locomotion distance, session 80.10.20.40.20.6-0.10.20.60.4-0.40.6
Degree of sensitization distance0.30.30.4-0.7-0.5-0.6-0.7-0.5-0.5-0.5-0.5
Degree of sensitization stereotypy2.32.52.9-1.6-1.6-1.7-1.6-1.6-1.7-1.6-1.5
Condit. Reinf. active minus inactive responses4.65.26.12.32.52.12.32.52.41.72.5
Condit. Reinf. active-inactive response ratio2.72.93.41.71.51.81.71.51.71.81.8
Condit. Reinf. active responses2.93.54.72.02.21.62.02.21.80.72.2
Condit. Reinf. inactive responses0.40.50.60.70.80.20.80.80.4-0.80.7
Incentive salience index mean1.92.33.41.51.81.21.51.81.60.61.8
Condit. Reinf. lever presses0.40.63.1-0.3-0.2-0.9-0.3-0.2-0.7-1.8-0.2
Time in familiar zone, hab. session 12.92.83.31.71.51.81.71.51.61.71.8
Time in novel zone, hab. session 11.91.82.4-1.3-1.2-1.5-1.3-1.2-1.4-1.5-1.4
Total zone transitions, hab. session 10.40.60.90.81.00.30.91.00.6-0.60.7
Total locomotion distance, hab. session 10.50.81.40.71.20.10.81.20.6-1.00.9
Locomotion velocity, hab. session 10.91.22.21.01.50.41.11.51.0-0.71.2
Time in familiar zone, hab. session 27.37.68.62.82.62.92.82.62.82.72.9
Time in novel zone, hab. session 25.75.76.2-2.4-2.3-2.5-2.4-2.3-2.4-2.3-2.5
Total zone transitions, hab. session 21.01.35.3-0.7-0.6-1.4-0.7-0.6-1.1-2.3-0.8
Total locomotion distance, hab. session 20.50.60.80.80.90.30.90.90.5-0.80.9
Locomotion velocity, hab. session 20.40.61.30.70.80.10.80.80.4-1.20.8
Novel to familiar place preference ratio5.96.26.9-2.4-2.4-2.6-2.4-2.4-2.6-2.6-2.5
Novelty place preference3.84.04.8-1.9-1.9-2.1-1.9-1.9-2.0-2.2-1.9
Time in novel zone, NPP test3.94.14.8-2.0-1.9-2.2-2.0-1.9-2.1-2.1-2.0
Total zone transitions, NPP test0.30.52.4-0.2-0.3-0.7-0.2-0.3-0.7-1.5-0.4
Total locomotion distance, NPP test0.30.52.3-0.4-0.2-0.9-0.4-0.2-0.5-1.5-0.4
Locomotion velocity, NPP test0.20.31.9-0.10.0-0.6-0.10.0-0.3-1.4-0.1
Pavlov. Cond. lever latency0.20.21.00.3-0.30.60.3-0.3-0.01.0-0.1
Pavlov. Cond. magazine entry latency3.95.06.42.12.52.02.12.52.41.72.4
Pavlov. Cond. change in total contacts0.30.30.60.20.80.10.20.80.70.10.6
Pavlov. Cond. index score0.60.81.60.61.30.40.61.31.00.01.1
Pavlov. Cond. latency score0.50.71.40.51.20.20.51.20.9-0.31.0
Pavlov. Cond. lever contacts0.20.21.0-0.10.5-0.5-0.10.50.1-1.00.2
Pavlov. Cond. magazine entry number1.11.42.1-1.0-1.4-0.9-1.0-1.4-1.3-0.7-1.3
Pavlov. Cond. intertrial magazine entries0.30.41.00.60.30.80.60.30.51.00.4
Pavlov. Cond. lever-magazine prob. diff.1.01.32.20.91.50.70.91.51.30.31.4
Pavlov. Cond. response bias1.61.92.91.21.71.11.21.71.60.81.5
Bone: apparent density0.81.44.8-0.6-1.0-1.1-0.6-1.0-1.3-2.2-0.7
Bone surface0.61.16.2-0.2-0.5-1.0-0.2-0.5-1.1-2.5-0.3
Bone volume0.71.36.4-0.3-0.6-1.0-0.2-0.6-1.2-2.5-0.4
Bone: connectivity density1.01.53.9-0.9-1.1-1.2-0.8-1.1-1.4-2.0-1.0
Bone: cortical apparent density1.01.31.9-0.9-1.4-0.9-0.9-1.4-1.2-0.7-1.3
Bone: cortical area0.91.31.9-1.2-1.0-1.2-1.2-1.0-1.2-1.4-1.1
Bone: cortical porosity0.20.20.20.40.50.30.50.50.3-0.20.5
Bone: cortical porosity0.20.21.0-0.3-0.1-0.5-0.2-0.1-0.4-1.0-0.2
Bone: cortical thickness1.42.42.5-1.5-1.5-1.6-1.5-1.5-1.6-1.5-1.6
Bone: cortical thickness0.10.20.90.20.10.50.20.10.30.90.2
Bone: cortical tissue density0.70.91.4-0.7-1.2-0.7-0.7-1.2-1.1-0.6-1.1
Bone: elastic displacement0.10.10.30.50.00.40.50.00.00.10.4
Bone: elastic work0.40.50.8-0.7-0.9-0.6-0.7-0.9-0.8-0.6-0.5
Bone: endosteal estimation0.10.30.5-0.7-0.4-0.7-0.7-0.4-0.4-0.4-0.4
Bone: endosteal perimeter0.10.30.50.50.70.30.50.70.5-0.00.7
Bone: final force1.42.33.0-1.7-1.4-1.6-1.7-1.4-1.4-1.4-1.5
Bone: final moment1.11.92.4-1.5-1.3-1.4-1.5-1.3-1.3-1.3-1.3
Bone: marrow area0.10.30.5-0.7-0.4-0.7-0.7-0.4-0.4-0.4-0.4
Bone: maximum diameter0.30.60.90.81.00.50.81.00.7-0.20.9
Bone: maximum force1.22.13.0-1.7-1.3-1.5-1.7-1.3-1.3-1.2-1.4
Bone: maximum moment1.01.72.4-1.5-1.3-1.3-1.5-1.3-1.2-1.1-1.3
Bone: minimum diameter0.00.10.1-0.20.2-0.3-0.20.20.1-0.4-0.0
Bone: periosteal estimation0.40.91.4-1.0-0.7-1.1-1.0-0.7-0.9-1.2-0.8
Bone: periosteal perimeter0.00.10.4-0.10.2-0.2-0.10.2-0.1-0.60.1
Bone: post-yield work0.20.30.7-0.8-0.3-0.6-0.8-0.3-0.2-0.1-0.6
Bone: stiffness2.74.25.9-2.4-1.8-2.2-2.4-1.8-1.8-1.7-2.2
Bone: tissue strength2.22.12.3-1.4-1.5-1.4-1.4-1.5-1.5-1.3-1.5
Bone: trabecular number0.20.30.50.60.60.20.70.60.3-0.70.7
Bone: trabecular spacing0.30.42.6-0.2-0.10.5-0.2-0.10.31.6-0.2
Bone: trabecular thickness1.82.28.1-0.8-1.1-1.5-0.7-1.1-1.6-2.8-0.9
Bone: trabecular tissue density1.01.42.1-1.4-1.1-1.1-1.5-1.1-1.0-0.5-1.3
Breakpoint value in progressive ratio session5.96.57.02.62.62.62.62.62.62.22.6
Distance traveled before self-admin0.80.91.1-0.9-1.0-1.0-0.9-0.9-1.0-1.0-0.9
Distance traveled after self-admin0.30.30.50.60.60.40.70.60.50.20.7
Delta time in closed arm before/after self-admin0.30.31.3-0.5-0.40.1-0.5-0.5-0.01.1-0.4
Delta time in open arm before/after self-admin1.51.41.8-1.1-1.3-1.2-1.2-1.2-1.3-1.2-1.1
Diff in mean of infusions in LGA sessions1.92.12.61.51.41.41.61.61.41.11.6
Extinction: sum of active levers before priming1.61.61.91.31.21.31.21.31.31.41.3
Active lever presses in extinction session 61.71.62.31.41.21.21.51.41.10.71.5
Delta distance traveled before/after self-admin1.71.82.21.31.51.21.41.51.40.91.4
Delta ambulatory time before/after self-admin1.71.92.51.31.61.21.41.51.40.81.5
Time in closed arm before self-admin1.41.63.2-1.1-1.0-1.4-1.1-1.0-1.3-1.8-1.1
Time in closed arm after self-admin0.00.00.10.10.20.20.20.20.20.30.2
Time in open arm before self-admin0.80.91.10.91.00.90.90.81.10.90.9
Time in open arm after self-admin0.70.81.0-0.9-1.0-0.7-0.9-1.0-0.9-0.5-0.9
Sum of active levers in priming session hrs 5-60.00.00.0-0.1-0.2-0.2-0.1-0.1-0.2-0.2-0.0
Time to tail flick, vehicle, before self-admin0.10.10.20.40.30.20.50.40.1-0.50.4
Time to tail flick, vehicle, after self-admin0.60.71.50.70.71.00.60.60.91.20.7
Time to tail flick, test, before self-admin0.10.10.30.20.1-0.10.20.1-0.0-0.60.2
Time to tail flick, test, after self-admin0.20.20.50.50.70.50.50.50.50.00.5
Delta time to tail flick, vehicle, before/after SA0.10.10.9-0.10.00.2-0.2-0.20.31.0-0.2
Delta time to tail flick, test, before/after SA0.60.61.10.60.80.80.60.70.91.00.6
Ambulatory time before self-admin0.80.81.0-0.8-1.0-0.9-0.8-0.9-1.0-0.9-0.8
Ambulatory time after self-admin0.10.10.30.40.40.20.50.50.30.10.5
Total heroin consumption1.72.02.41.51.41.41.61.51.30.91.5
Area under the delay curve2.22.42.7-1.6-1.6-1.5-1.6-1.6-1.5-1.1-1.6
Delay disc. indifference point, 0s delay10.111.013.3-3.2-3.2-3.4-3.1-3.2-3.5-3.7-3.2
Delay disc. indifference point, 16s delay0.10.10.2-0.3-0.4-0.3-0.3-0.4-0.3-0.2-0.4
Delay disc. indifference point, 2s delay6.16.87.4-2.7-2.6-2.6-2.7-2.6-2.6-2.4-2.6
Delay disc. indifference point, 24s delay0.70.70.9-0.8-1.0-0.8-0.9-1.0-0.8-0.4-0.9
Delay disc. indifference point, 4s delay1.01.01.1-1.0-1.0-1.0-1.0-1.0-1.0-1.0-1.0
Delay disc. indifference point, 8s delay0.90.91.3-1.1-1.0-0.8-1.2-1.0-0.8-0.3-1.0
Delay discount exponential model param2.02.12.41.61.51.41.61.51.41.01.5
Delay discount hyperbolic model param2.83.03.51.91.81.71.91.81.71.31.8
Fecal boli incidents, locomotor time 11.51.62.2-1.4-1.2-1.5-1.4-1.2-1.2-0.8-1.2
Change in fecal boli incidents, locomotor task0.00.00.10.20.40.00.20.20.3-0.00.1
Time >=10cm from walls, locomotor time 11.61.62.6-1.2-1.2-1.4-1.1-1.1-1.3-1.6-1.2
Bouts of movement, locomotor time 10.40.50.90.40.90.50.40.70.90.70.6
Total resting periods, locomotor time 10.40.50.90.50.90.50.50.80.90.60.7
Rest time, locomotor task time 10.50.61.30.51.20.30.50.91.00.30.8
Distance moved, locomotor task time 11.61.72.4-1.1-1.5-1.3-1.0-1.3-1.5-1.5-1.2
Vertical activity count, locomotor time 10.30.41.0-0.3-1.0-0.1-0.4-0.7-0.70.2-0.7
Time >=10cm from walls, locomotor time 21.31.42.0-1.4-1.2-1.0-1.4-1.3-1.1-0.6-1.3
Bouts of movement, locomotor time 20.20.20.30.50.50.30.60.50.3-0.40.6
Total resting periods, locomotor time 20.20.20.30.50.40.30.50.50.2-0.50.5
Rest time, locomotor task time 20.30.40.60.60.80.50.70.70.60.00.8
Distance moved, locomotor task time 20.50.50.7-0.8-0.8-0.6-0.9-0.8-0.7-0.3-0.8
Vertical activity count, locomotor time 20.30.40.6-0.7-0.8-0.3-0.7-0.6-0.50.3-0.6
Weight adjusted by age0.20.20.4-0.4-0.5-0.1-0.4-0.4-0.20.6-0.5
Seeking ratio, delayed vs. immediate footshock3.43.94.62.12.11.82.22.12.01.22.1
Locomotion in novel chamber0.20.30.60.50.50.60.50.40.60.70.4
Locomotion in novel chamber post-restriction1.41.72.31.11.51.21.11.41.51.31.2
Progressive ratio0.00.00.1-0.3-0.1-0.2-0.3-0.1-0.0-0.0-0.1
Food seeking constrained by brief footshock0.30.40.90.41.00.20.50.80.8-0.10.6
Seeking ratio, punishment vs. effort0.10.10.30.40.50.20.40.50.4-0.10.3
Run reversals in cocaine runway, females0.40.40.60.60.80.50.60.70.70.30.7
Run reversals in cocaine runway, males1.21.21.51.21.21.01.21.11.10.51.2
Latency to leave start box in cocaine runway0.10.10.40.50.00.10.50.2-0.2-0.70.1
Latency to leave start box in cocaine runway, F1.31.43.7-0.7-1.1-1.1-0.6-1.0-1.5-1.9-1.0
Latency to leave start box in cocaine runway, M3.83.64.21.91.82.01.82.01.92.11.8
Cd content in liver0.40.50.9-0.5-0.7-0.6-0.5-0.7-0.8-0.7-0.9
Co content in liver0.60.71.00.80.90.80.81.00.90.70.9
Cu content in liver0.40.51.4-0.5-0.4-0.8-0.6-0.4-0.7-1.2-0.5
Fe content in liver0.30.30.60.20.80.40.30.80.70.60.5
K content in liver0.30.31.1-0.30.3-0.7-0.30.2-0.0-1.0-0.3
Mg content in liver0.30.31.3-0.40.1-0.7-0.4-0.0-0.3-1.1-0.4
Mn content in liver0.50.51.00.51.0-0.10.51.00.5-1.00.7
Na content in liver1.31.32.8-1.2-0.7-1.5-1.2-0.7-1.0-1.7-1.0
Rb content in liver0.91.12.3-1.0-0.8-1.2-0.9-0.8-1.0-1.5-1.0
Se content in liver0.40.51.10.51.00.30.40.90.90.20.9
Sr content in liver0.20.20.80.20.20.50.20.30.40.90.3
Zn content in liver3.03.35.41.81.52.11.71.51.82.31.7