Hub : Genes

Thrsp

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000012404	0.38	0.16	0.0e+00	0.16	0.16	0.16	0.15	2.2e-17	7.0e-17	2.0e-17	1.4e-16
2	BLA	gene expression	ENSRNOG00000012404	0.08	0.05	2.3e-04	0.07	0.06	0.07	0.06	9.5e-05	5.3e-04	1.9e-04	6.3e-04
3	Brain	gene expression	ENSRNOG00000012404	0.22	0.09	0.0e+00	0.25	0.25	0.23	0.25	4.0e-23	8.0e-23	2.1e-21	4.3e-23
4	Eye	gene expression	ENSRNOG00000012404	0.5	0.21	5.6e-03	0.07	-0.01	-0.02	0.01	3.0e-02	6.1e-01	7.8e-01	2.6e-01
5	IL	gene expression	ENSRNOG00000012404	0.33	0.14	2.4e-04	0.09	0.09	0.07	0.09	4.1e-03	3.1e-03	7.3e-03	2.9e-03
6	Liver	gene expression	ENSRNOG00000012404	0.06	0.04	5.1e-05	0.01	0.03	0.03	0.02	1.2e-02	7.0e-04	2.4e-04	4.4e-03
7	Liver	mRNA stability	ENSRNOG00000012404	0.11	0.08	6.3e-06	0.05	0.04	0.05	0.05	1.7e-06	1.4e-05	3.0e-06	5.8e-06
8	NAcc	gene expression	ENSRNOG00000012404	0.04	0.03	3.5e-03	0.02	0.02	0.02	0.02	9.4e-03	9.8e-03	1.5e-02	8.6e-03
9	PL	gene expression	ENSRNOG00000012404	0.15	0.07	3.5e-11	0.14	0.14	0.15	0.14	1.1e-10	4.0e-11	3.1e-11	3.6e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
BMI with tail	0.3	0.9	3.6	1.3	0.6	0.9	-1.0	-0.2	1.9	0.2	-0.8	-0.8
BMI without tail	0.9	2.0	8.3	1.6	1.0	1.0	-1.1	-1.0	2.9	-0.2	-1.0	-1.2
Body weight	0.4	1.9	9.6	1.6	0.3	0.7	-1.3	-0.1	3.1	0.5	-1.0	-1.0
Epididymis fat weight	0.8	1.8	5.1	1.1	0.2	0.7	-1.4	-1.5	2.3	-1.8	-0.9	-1.2
Glucose	0.4	0.6	1.1	-0.8	-1.1	-0.5	0.4	1.0	-0.5	1.0	0.7	0.6
Heart weight	1.3	1.8	2.4	-1.2	-1.3	-1.3	1.4	1.3	-1.5	1.0	1.5	1.5
Left kidney weight	0.2	0.7	1.2	-0.7	-1.0	-0.8	1.0	0.6	0.1	0.9	1.1	0.8
Right kidney weight	0.1	0.2	0.4	-0.1	-0.4	-0.3	0.4	0.2	0.5	0.7	0.4	0.3
Tail length	0.2	0.5	1.5	-0.1	-0.7	-0.7	0.6	0.3	1.2	0.8	0.7	0.5
Length with tail	0.2	0.7	4.7	0.7	-0.3	0.0	-0.4	0.0	2.2	0.7	-0.3	-0.4
Length without tail	0.2	0.5	1.0	0.8	0.2	0.5	-0.9	0.2	1.0	0.5	-0.8	-0.6
Liver weight, left	0.4	0.6	2.4	0.8	0.1	0.4	-0.9	-0.2	1.5	-0.1	-0.8	-0.8
Liver weight, right	3.6	6.0	12.1	2.4	1.6	2.0	-2.8	-2.3	3.5	-2.2	-2.3	-2.5
Parametrial fat weight	1.2	2.3	5.0	2.1	1.3	1.2	-1.6	-0.9	2.2	-0.5	-1.6	-1.4
Retroperitoneal fat weight	2.0	6.6	22.1	2.8	1.3	1.9	-2.7	-2.0	4.7	-1.3	-2.3	-2.5
Intraocular pressure	4.1	5.7	7.4	-2.7	-2.3	-2.0	2.2	2.6	-2.7	2.2	2.4	2.3
Extensor digitorum longus weight	0.1	0.5	1.9	0.0	-0.8	-0.5	0.3	1.1	0.4	1.4	0.5	0.5
Soleus weight	0.1	0.2	1.3	0.6	0.1	0.1	-0.2	-0.0	1.2	0.5	-0.2	-0.2
Tibialis anterior weight	0.1	0.2	0.8	0.6	0.0	0.1	-0.4	0.2	0.9	0.4	-0.3	-0.2
Tibia length	0.5	1.5	2.9	-1.4	-1.2	-1.1	1.3	1.0	-1.7	0.4	1.4	1.3
Number of licking bursts	2.8	3.4	4.7	2.2	1.7	1.8	-2.0	-1.5	2.1	-1.3	-2.0	-1.8
Food consumed during 24 hour testing period	1.0	1.2	2.9	-1.7	-0.9	-0.6	1.2	0.8	-1.4	1.1	1.2	0.7
Times rat made contact with spout	0.9	1.0	1.9	0.8	0.8	1.2	-0.9	-1.0	1.4	-0.5	-1.0	-1.1
Mean time between licks in bursts	1.8	2.4	4.0	-1.9	-1.9	-1.6	1.8	1.0	-1.2	0.6	2.0	1.6
Mean num. licks in bursts	2.1	2.6	3.9	-2.0	-1.6	-1.5	1.8	1.4	-1.6	1.3	1.7	1.5
Std. dev. time between licks in bursts	0.1	0.1	0.3	0.1	0.1	0.1	0.3	-0.4	0.5	-0.1	0.1	-0.1
Water consumed over 24 hours	1.4	1.7	2.4	1.2	1.4	1.5	-1.3	-1.2	1.3	-0.6	-1.4	-1.5
Indifference point 0 sec	1.7	2.7	4.1	-1.3	-1.6	-1.6	1.6	2.0	-1.1	2.0	1.6	1.7
Indifference point AUC	0.2	0.2	0.4	-0.4	-0.4	-0.6	0.5	0.4	-0.5	0.3	0.5	0.5
Indifference point function ln k	0.2	0.3	1.0	-0.3	-0.2	-0.2	0.4	0.8	-0.5	1.0	0.2	0.4
Indifference point function log k	0.2	0.3	1.0	-0.3	-0.2	-0.2	0.4	0.8	-0.5	1.0	0.2	0.4
Delay discounting total patch changes 0 sec	1.6	2.7	4.1	-1.2	-1.6	-1.6	1.6	2.0	-1.2	2.0	1.6	1.7
Delay discounting total patch changes 12 sec	0.5	0.6	1.0	-0.8	-1.0	-1.0	0.8	0.4	-0.7	0.0	1.0	0.9
Delay discounting total patch changes 18 sec	1.8	2.4	3.4	-1.4	-1.3	-1.6	1.8	1.4	-1.4	1.4	1.7	1.6
Delay discounting total patch changes 24 sec	0.7	0.9	1.6	-1.0	-0.9	-1.0	1.2	0.4	-1.0	0.2	1.3	1.1
Delay discounting total patch changes 6 sec	0.2	0.2	1.1	0.2	-0.2	-0.4	0.1	0.9	0.1	1.1	0.0	0.3
Delay discounting time to switch 0 sec	3.9	5.9	7.3	2.3	2.3	2.4	-2.4	-2.7	2.1	-2.6	-2.6	-2.5
Delay discounting water rate 0 sec	2.6	4.2	5.0	-2.1	-2.0	-2.1	2.1	2.1	-2.0	1.8	2.2	2.1
Delay discounting water rate 12 sec	2.1	3.2	6.0	-1.6	-1.5	-1.7	1.7	2.2	-1.4	2.5	1.6	1.6
Delay discounting water rate 18 sec	1.5	2.0	3.6	-1.2	-1.5	-1.3	1.3	1.7	-0.9	1.9	1.3	1.3
Delay discounting water rate 24 sec	1.2	1.6	3.9	-1.1	-1.2	-0.9	1.2	1.6	-1.1	2.0	1.0	1.0
Delay discounting water rate 6 sec	0.7	1.0	1.7	-1.0	-0.7	-0.8	1.0	1.2	-1.1	1.3	0.9	0.9
Locomotor activity	0.2	0.3	1.0	0.6	0.7	0.5	0.2	-0.2	0.6	1.0	-0.4	-0.2
Locomotor testing distance	0.7	1.2	2.6	-0.6	-0.6	-0.9	1.6	0.9	-0.6	1.6	1.1	1.3
Locomotor testing rearing	0.1	0.1	0.5	0.3	0.0	-0.2	0.4	-0.0	0.7	0.5	0.2	0.3
Light reinforcement 1	1.6	2.9	3.5	1.9	1.5	1.6	-1.7	-1.7	1.8	-1.7	-1.7	-1.6
Light reinforcement 2	0.4	0.5	1.5	0.6	0.5	0.6	-0.7	-0.8	0.4	-1.2	-0.7	-0.6
Reaction time number correct	0.5	0.7	1.6	1.0	1.3	1.0	-0.5	-0.6	0.4	0.1	-1.0	-0.7
Reaction time mean minus median	0.4	0.5	1.4	-0.3	-0.6	-0.5	0.7	0.8	-0.2	1.2	0.6	0.7
Reaction time mean minus median AUC	0.3	0.3	1.2	-0.3	-0.5	-0.4	0.6	0.8	-0.3	1.1	0.5	0.5
Reaction time num false alarms	0.5	0.6	1.1	0.8	0.8	1.0	-0.7	-0.7	1.0	-0.4	-0.8	-0.7
Reaction time num false alarms AUC	0.1	0.2	0.5	0.2	0.4	0.7	-0.2	-0.5	0.3	-0.3	-0.3	-0.4
Reaction time trials correct on left	0.5	0.7	1.6	1.0	1.3	1.0	-0.5	-0.6	0.4	0.1	-1.0	-0.7
Reaction time trials on left	0.5	0.7	1.5	1.1	1.2	1.0	-0.5	-0.6	0.4	0.0	-1.0	-0.7
Reaction time mean	0.3	0.4	0.8	0.9	0.3	0.5	-0.6	-0.6	0.7	-0.7	-0.7	-0.4
Reaction time mean AUC	0.3	0.4	0.8	0.9	0.3	0.5	-0.7	-0.5	0.7	-0.7	-0.7	-0.4
Median of all reaction times	0.5	0.7	1.7	1.0	0.5	0.6	-0.9	-0.9	0.7	-1.3	-0.8	-0.6
Reaction time omissions	0.1	0.2	0.3	0.1	-0.5	-0.4	0.4	0.6	-0.1	0.5	0.4	0.6
Reaction time false alarm rate	0.0	0.1	0.3	-0.2	-0.2	0.3	-0.1	-0.2	0.2	-0.6	0.0	-0.0
Reaction time premature initiation rate	0.1	0.2	0.7	0.3	-0.7	-0.4	0.2	0.1	0.8	0.0	0.2	0.3
Reaction time premature initiations	0.1	0.1	0.5	0.6	-0.1	-0.0	0.1	-0.2	0.7	0.1	-0.1	0.0
Std. dev. reaction times	0.2	0.2	0.6	-0.0	-0.5	-0.4	0.6	0.5	0.1	0.8	0.4	0.6
Reaction time trials completed	0.5	0.7	1.5	1.1	1.2	1.0	-0.5	-0.6	0.4	0.0	-1.0	-0.7
Reaction time trials AUC	0.4	0.6	1.4	1.0	1.2	0.9	-0.4	-0.6	0.4	0.1	-0.9	-0.7
Social response proportion	2.9	3.1	3.8	1.8	1.6	1.7	-1.7	-1.9	1.8	-1.9	-1.7	-1.7
Social responses	1.1	1.4	3.3	1.5	1.0	1.2	-1.0	-1.0	1.8	-0.5	-1.2	-1.1
Social time	2.4	3.2	4.0	2.0	1.8	1.6	-1.7	-1.9	1.6	-1.8	-1.9	-1.6
Conditioned locomotion	0.1	0.1	0.7	0.2	0.2	0.2	-0.1	0.4	0.1	0.8	-0.2	-0.1
Cocaine response after cond. corrected	0.1	0.1	0.4	-0.2	-0.6	-0.4	0.2	0.1	-0.3	-0.5	0.3	0.5
Cocaine response after cond. not corrected	0.1	0.2	0.9	-0.1	-0.4	-0.2	-0.0	-0.1	-0.4	-0.9	0.2	0.3
Cocaine response before conditioning	0.6	0.8	1.8	0.6	1.0	0.9	-0.8	-1.1	0.2	-1.3	-0.8	-0.8
Saline control response	1.0	1.3	4.3	-0.5	-0.9	-1.1	1.1	1.5	-0.3	2.1	0.9	1.1
Condit. Reinf. active minus inactive responses	5.4	6.7	8.1	-2.3	-2.6	-2.8	2.6	2.7	-2.1	2.3	2.9	2.8
Condit. Reinf. active-inactive response ratio	3.5	3.7	4.3	-1.7	-1.8	-2.0	1.9	2.0	-1.8	1.7	2.1	2.1
Condit. Reinf. active responses	5.9	8.2	9.9	-2.4	-3.0	-3.1	2.9	3.0	-2.1	2.7	3.2	3.1
Condit. Reinf. inactive responses	0.9	1.1	1.7	-0.8	-1.2	-1.1	1.2	1.1	-0.3	1.3	1.2	1.1
Condit. Reinf. lever presses	12.3	16.9	22.1	-3.6	-4.1	-4.2	3.9	4.7	-3.6	4.3	4.2	4.2
Condit. Reinf. lever reinforcers received	6.7	9.5	11.5	-2.7	-3.2	-3.4	3.1	3.2	-2.4	2.7	3.4	3.4
Pavlov. Cond. lever latency	16.5	22.6	28.6	4.1	4.5	4.8	-4.7	-5.4	4.4	-5.0	-4.8	-5.0
Pavlov. Cond. magazine entry latency	6.8	7.8	10.3	-2.4	-2.5	-2.9	2.7	3.2	-3.0	2.8	2.8	2.9
Pavlov. Cond. change in total contacts	9.8	13.7	17.9	-3.2	-3.6	-3.8	3.6	4.2	-3.3	3.8	3.7	3.9
Pavlov. Cond. index score	13.9	18.2	22.8	-3.7	-4.1	-4.4	4.2	4.8	-4.1	4.2	4.3	4.5
Pavlov. Cond. latency score	13.1	16.6	21.1	-3.5	-3.8	-4.2	4.0	4.6	-4.0	4.1	4.1	4.3
Pavlov. Cond. lever contacts	14.9	20.7	27.4	-3.8	-4.4	-4.6	4.5	5.2	-4.0	5.0	4.6	4.7
Pavlov. Cond. magazine entry number	14.5	17.9	20.9	4.0	4.0	4.3	-4.1	-4.6	4.4	-3.8	-4.4	-4.4
Pavlov. Cond. intertrial magazine entries	0.9	1.1	2.2	0.9	1.0	1.0	-0.6	-1.4	1.5	-1.0	-0.8	-0.9
Pavlov. Cond. lever-magazine prob. diff.	13.2	17.0	21.3	-3.6	-4.0	-4.3	4.0	4.6	-3.9	4.0	4.2	4.3
Pavlov. Cond. response bias	16.6	22.9	27.7	-4.3	-4.6	-4.9	4.8	5.3	-4.5	4.7	4.9	5.0
Conditioned reinforcement - actives	2.1	2.1	4.8	-2.0	-1.4	-1.4	1.1	0.6	-2.2	-0.6	1.6	1.2
Conditioned reinforcement - inactives	0.3	0.4	1.2	0.2	-0.1	0.6	-0.7	-0.6	0.2	-1.1	-0.4	-0.6
Conditioned locomotion	1.2	1.5	3.5	-1.8	-1.3	-1.1	0.8	0.4	-1.9	-0.6	1.3	0.9
Intermittent access intake day 1-15 change	1.4	1.4	2.1	-1.4	-1.3	-1.1	1.1	1.1	-1.4	0.8	1.2	1.1
Intermittent access intake escalation	2.0	2.0	2.7	-1.6	-1.5	-1.3	1.4	1.3	-1.6	1.1	1.4	1.3
Intermittent access intake escalation 2	0.3	0.3	0.7	-0.8	-0.8	-0.5	0.4	0.1	-0.6	-0.3	0.7	0.5
Intermitt. access day 1 inactive lever presses	1.4	1.5	4.1	0.7	0.7	1.1	-1.1	-1.7	0.8	-2.0	-1.0	-1.2
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.1	0.3	-0.2	0.3	-0.4	-0.2	0.1	-0.3	-0.3	-0.2
Intermitt. access escalation Index	0.6	0.5	0.9	0.7	0.5	0.7	-0.9	-0.4	0.9	-0.3	-0.8	-0.9
Intermittent access day 1 total infusions	1.1	1.3	2.0	-1.3	-1.4	-1.2	0.9	1.1	-1.1	0.5	1.3	1.1
Intermittent access day 15 total infusions	2.6	3.0	4.6	-2.1	-2.1	-1.8	1.4	1.6	-2.0	0.8	1.8	1.5
Intermittent access terminal intake (last 3 days)	1.3	1.4	2.7	-1.6	-1.6	-1.2	0.8	0.9	-1.3	-0.0	1.3	1.0
Intermittent access total infusions	1.0	1.1	2.2	-1.5	-1.5	-1.0	0.6	0.5	-1.1	-0.5	1.2	0.8
Intermittent access day 1 locomotion	0.3	0.3	1.3	-0.7	-0.3	-0.1	-0.3	-0.3	-0.5	-1.1	0.2	-0.2
Intermittent access day 15 total locomotion	1.2	1.2	2.2	-1.5	-1.3	-1.2	0.9	0.9	-1.2	0.2	1.3	1.0
Intermittent access total locomotion	0.5	0.5	1.4	-1.2	-1.0	-0.7	0.3	0.2	-0.7	-0.6	0.8	0.4
Intermittent access standard deviation	0.1	0.2	0.9	-0.3	-0.4	0.1	-0.2	-0.5	0.0	-0.9	0.1	-0.2
Cocaine induced anxiety	1.3	1.5	2.1	1.5	1.4	1.3	-1.2	-1.1	1.2	-0.6	-1.4	-1.2
Post-drug Anxiety	0.1	0.1	0.3	0.5	0.3	0.3	0.1	0.1	0.2	0.6	-0.3	0.0
Baseline Anxiety	3.1	3.3	4.0	-1.8	-1.7	-1.7	2.0	1.8	-1.9	1.7	1.9	1.9
Lifetime Intake	1.3	1.4	2.5	-1.6	-1.5	-1.2	1.0	0.7	-1.5	-0.3	1.4	1.1
Incentive Sensitization - Responses	2.5	2.5	5.3	-1.9	-2.3	-1.8	1.2	1.3	-1.2	0.5	1.9	1.5
Incentive Sensitization - Breakpoint	2.3	2.3	5.2	-1.9	-2.3	-1.7	1.1	1.2	-1.1	0.3	1.8	1.4
Progressive ratio test 1 active lever presses	0.2	0.2	0.6	0.2	0.3	0.6	-0.5	-0.4	0.1	-0.8	-0.4	-0.4
Progressive ratio test 1 breakpoint	0.3	0.3	1.1	0.2	0.4	0.7	-0.6	-0.6	0.1	-1.1	-0.4	-0.5
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.3	-0.2	-0.2	-0.0	-0.0	-0.2	-0.2	-0.6	0.2	0.1
Progressive ratio test 2 active lever presses	2.1	2.2	4.4	-1.9	-2.1	-1.6	1.2	1.1	-1.3	0.1	1.8	1.3
Progressive ratio test 2 breakpoint	1.3	1.5	3.4	-1.6	-1.8	-1.3	0.9	0.8	-1.0	-0.1	1.5	1.1
Progressive ratio test 2 inactive lever presses	0.8	0.9	1.8	-1.2	-1.3	-1.0	0.6	0.6	-1.0	-0.3	1.1	0.9
Total sessions with >9 infusions	0.6	0.7	1.8	-1.0	-1.0	-0.6	0.8	0.3	-1.3	-0.4	0.9	0.8
Short access day 1 total inactive lever presses	0.2	0.2	0.6	-0.5	-0.8	-0.4	0.3	0.3	-0.6	-0.1	0.5	0.5
Short access day 10 total inactive lever presses	1.8	2.0	3.0	1.5	1.0	1.4	-1.6	-1.1	1.7	-0.7	-1.6	-1.5
Short access day 1 total infusions	1.2	1.3	2.1	-1.3	-1.3	-1.0	1.1	0.5	-1.5	-0.5	1.3	1.2
Short access day 10 total infusions	1.5	1.6	2.5	-1.6	-1.3	-1.3	1.3	0.7	-1.6	-0.1	1.5	1.3
Short access total infusions	0.7	0.8	1.5	-1.1	-0.9	-0.7	0.8	0.2	-1.2	-0.7	1.0	0.8
Short access day 1 locomotion	1.5	1.6	3.8	-1.5	-1.3	-1.1	1.2	0.9	-2.0	0.1	1.2	1.2
Short access day 10 total locomotion	0.1	0.1	0.3	-0.5	-0.4	-0.2	0.2	-0.0	-0.3	-0.2	0.4	0.1
Short access total locomotion	0.5	0.5	2.8	-0.1	0.2	0.4	-0.4	-1.1	-0.3	-1.7	-0.3	-0.4
Compulsive drug intake	0.1	0.1	0.4	0.1	0.2	0.3	-0.1	-0.4	0.0	-0.6	-0.2	-0.2
One hour access (0.3 mA shock)	2.2	2.5	4.4	-1.8	-2.1	-1.6	1.6	1.1	-1.6	0.5	1.8	1.6
One hour access (shock baseline)	1.3	1.5	2.6	-1.4	-1.6	-1.3	1.2	1.0	-1.2	0.7	1.3	1.2
Number of responses in last shaping day	0.5	0.5	3.3	-0.1	-0.1	0.1	-0.1	-1.0	0.0	-1.8	0.2	-0.0
Context. condit. distance diff. score	3.2	3.9	6.3	-2.3	-2.0	-1.9	1.9	1.7	-2.5	0.8	2.2	2.0
Locomotion velocity, session 1	0.5	0.5	1.8	-0.8	-0.4	-0.5	0.8	0.4	-1.3	0.4	0.7	0.6
Locomotion distance, session 1	0.4	0.6	1.6	-0.6	-0.5	-0.7	0.9	0.4	-1.3	0.1	0.7	0.9
Locomotion velocity, session 2	0.9	1.0	1.5	-1.2	-1.0	-0.8	1.2	0.7	-1.1	0.9	1.1	1.0
Locomotion distance, session 2	0.1	0.1	0.6	0.1	0.0	0.0	0.2	0.3	-0.0	0.8	0.0	0.1
Locomotion velocity, session 3	0.3	0.3	0.5	-0.7	-0.5	-0.6	0.6	0.5	-0.7	0.5	0.6	0.5
Locomotion distance, session 3	2.1	2.3	3.9	-1.8	-1.4	-1.6	1.5	1.3	-2.0	0.9	1.6	1.5
Stereotopy head waving bouts, day 3	3.9	4.7	5.9	2.0	2.0	2.0	-2.1	-2.4	2.4	-2.1	-2.2	-2.3
Stereotopy head waving duration, day 3	0.4	0.5	0.8	0.7	0.7	0.7	-0.7	-0.2	0.9	0.4	-0.8	-0.8
Locomotion velocity, session 7	0.3	0.4	0.6	-0.7	-0.5	-0.6	0.5	0.6	-0.8	0.3	0.6	0.6
Locomotion distance, session 7	1.1	1.4	1.9	-1.2	-1.3	-1.4	1.1	1.1	-1.2	0.5	1.3	1.3
Stereotopy head waving bouts, day 7	0.1	0.1	0.4	-0.3	0.1	0.3	-0.1	-0.5	-0.2	-0.6	-0.0	-0.3
Stereotopy head waving duration, day 7	0.2	0.2	0.5	-0.7	-0.4	-0.3	0.5	0.3	-0.6	0.4	0.5	0.4
Locomotion velocity, session 8	6.9	8.3	10.8	-3.1	-2.7	-2.7	2.7	3.1	-3.3	2.7	2.9	2.8
Locomotion distance, session 8	1.7	2.5	3.6	-1.7	-1.5	-1.4	1.6	1.5	-1.9	1.2	1.7	1.6
Degree of sensitization distance	0.1	0.1	0.4	0.5	0.0	0.0	-0.1	-0.2	0.7	-0.3	-0.1	0.0
Degree of sensitization stereotypy	1.3	1.5	3.1	-1.7	-1.1	-1.0	1.2	0.8	-1.8	0.3	1.3	1.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	0.1	-0.3	-0.5	0.3	0.4	0.3	0.5	0.3	0.4
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.3	-0.2	-0.4	0.1	0.3	0.5	0.4	0.1	0.2
Condit. Reinf. active responses	0.0	0.1	0.2	0.3	0.2	-0.1	0.0	-0.0	0.5	0.3	-0.0	-0.0
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.0	0.3	0.1	0.1	-0.2	-0.0	0.0	-0.0	-0.1
Incentive salience index mean	0.4	0.5	0.8	-0.6	-0.7	-0.9	0.8	0.6	-0.3	0.6	0.8	0.7
Condit. Reinf. lever presses	0.9	1.2	1.7	-1.3	-0.9	-1.1	1.2	0.9	-1.1	0.9	1.2	1.0
Time in familiar zone, hab. session 1	0.0	0.0	0.1	-0.3	-0.2	-0.2	0.1	0.1	-0.1	-0.0	0.2	0.1
Time in novel zone, hab. session 1	0.2	0.2	0.6	0.8	0.3	0.4	-0.3	-0.1	0.6	0.3	-0.4	-0.2
Total zone transitions, hab. session 1	0.4	0.6	1.1	1.0	0.9	0.8	-0.8	-0.0	0.5	0.4	-1.0	-0.7
Total locomotion distance, hab. session 1	5.6	8.0	10.1	3.0	2.6	2.5	-2.7	-3.2	3.2	-2.9	-2.8	-2.6
Locomotion velocity, hab. session 1	5.2	7.5	9.9	2.8	2.5	2.4	-2.6	-3.1	2.9	-3.0	-2.7	-2.5
Time in familiar zone, hab. session 2	1.0	1.0	2.1	-1.1	-0.9	-0.9	0.9	1.1	-0.6	1.4	1.1	0.8
Time in novel zone, hab. session 2	0.1	0.1	0.6	-0.0	-0.2	-0.2	0.1	-0.2	-0.3	-0.8	0.0	0.3
Total zone transitions, hab. session 2	0.2	0.2	0.8	0.6	0.3	0.0	-0.2	0.6	0.1	0.9	-0.4	0.0
Total locomotion distance, hab. session 2	2.7	3.5	5.3	2.3	1.8	1.5	-1.7	-2.0	2.3	-1.7	-1.9	-1.6
Locomotion velocity, hab. session 2	2.8	3.8	6.3	2.5	1.8	1.6	-1.8	-1.9	2.5	-1.5	-2.0	-1.7
Novel to familiar place preference ratio	0.2	0.2	0.4	0.6	0.2	0.5	-0.6	-0.1	0.6	-0.4	-0.6	-0.4
Novelty place preference	0.1	0.1	0.2	0.3	-0.1	0.3	-0.3	0.1	0.4	-0.1	-0.3	-0.2
Time in novel zone, NPP test	0.0	0.0	0.2	0.1	-0.3	0.1	-0.0	0.4	0.1	0.3	-0.0	0.1
Total zone transitions, NPP test	0.2	0.4	0.8	-0.2	-0.2	-0.4	0.5	0.8	-0.9	0.9	0.3	0.6
Total locomotion distance, NPP test	2.1	2.9	6.9	1.7	1.4	1.2	-1.4	-2.2	1.6	-2.6	-1.5	-1.2
Locomotion velocity, NPP test	3.0	4.3	9.5	2.1	1.7	1.5	-1.8	-2.7	1.9	-3.1	-1.8	-1.6
Pavlov. Cond. lever latency	1.1	1.4	2.1	1.4	1.1	1.2	-1.3	-0.9	1.2	-0.7	-1.4	-1.1
Pavlov. Cond. magazine entry latency	1.5	1.9	2.5	-1.3	-1.4	-1.5	1.4	1.3	-1.2	1.0	1.6	1.6
Pavlov. Cond. change in total contacts	1.6	1.7	2.6	-1.6	-1.4	-1.5	1.2	0.7	-1.5	-0.2	1.6	1.4
Pavlov. Cond. index score	2.2	2.8	4.0	-1.8	-1.7	-1.8	1.9	1.4	-1.6	1.2	2.0	1.8
Pavlov. Cond. latency score	1.8	2.3	3.3	-1.7	-1.6	-1.6	1.6	1.2	-1.4	0.9	1.8	1.6
Pavlov. Cond. lever contacts	1.3	1.6	2.4	-1.5	-1.2	-1.4	1.4	0.9	-1.2	0.8	1.5	1.2
Pavlov. Cond. magazine entry number	2.2	2.8	3.5	1.6	1.7	1.7	-1.7	-1.7	1.5	-1.5	-1.9	-1.8
Pavlov. Cond. intertrial magazine entries	0.9	1.1	1.9	0.9	1.2	0.9	-0.9	-1.4	0.9	-1.1	-1.0	-1.1
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.4	3.4	-1.7	-1.5	-1.6	1.7	1.2	-1.5	1.0	1.8	1.6
Pavlov. Cond. response bias	0.9	1.1	1.5	-1.1	-0.9	-1.1	1.2	0.7	-1.0	0.7	1.2	1.1
Bone: apparent density	0.0	0.0	0.1	0.0	0.2	0.2	-0.3	-0.1	0.1	-0.1	-0.2	-0.3
Bone surface	1.5	2.6	3.5	-1.9	-1.8	-1.7	1.5	1.5	-1.7	0.9	1.8	1.6
Bone volume	1.0	1.7	2.3	-1.5	-1.4	-1.4	1.3	1.3	-1.2	1.1	1.5	1.2
Bone: connectivity density	0.2	0.3	1.0	-0.8	-0.3	-0.4	0.3	0.1	-1.0	-0.3	0.5	0.3
Bone: cortical apparent density	0.2	0.3	0.4	0.7	0.5	0.6	-0.4	-0.2	0.6	0.4	-0.5	-0.5
Bone: cortical area	0.6	0.9	1.6	-0.8	-1.3	-1.0	0.8	1.1	-0.6	0.6	1.1	1.1
Bone: cortical porosity	0.1	0.2	0.5	0.3	0.3	0.4	-0.3	-0.5	0.0	-0.7	-0.4	-0.3
Bone: cortical porosity	0.3	0.4	1.2	0.3	0.5	0.6	-0.4	-0.9	0.1	-1.1	-0.5	-0.5
Bone: cortical thickness	0.0	0.1	0.2	0.4	0.1	0.2	-0.3	-0.2	0.3	-0.5	-0.2	-0.1
Bone: cortical thickness	1.2	1.4	2.6	-1.1	-1.3	-1.3	1.1	0.8	-1.6	-0.2	1.3	1.5
Bone: cortical tissue density	0.2	0.3	0.4	0.7	0.6	0.6	-0.4	-0.2	0.6	0.3	-0.6	-0.5
Bone: elastic displacement	0.3	0.3	0.5	0.7	0.5	0.6	-0.7	-0.3	0.4	-0.3	-0.7	-0.5
Bone: elastic work	0.2	0.3	0.5	0.6	0.6	0.6	-0.7	-0.1	0.0	-0.2	-0.7	-0.5
Bone: endosteal estimation	1.2	2.6	3.6	-1.7	-1.8	-1.7	1.8	1.4	-1.2	1.2	1.9	1.7
Bone: endosteal perimeter	2.7	5.6	6.9	-2.5	-2.5	-2.3	2.5	2.4	-2.0	2.3	2.6	2.3
Bone: final force	0.1	0.2	0.5	-0.3	-0.6	-0.5	0.2	0.7	-0.5	0.2	0.4	0.6
Bone: final moment	0.2	0.3	0.5	-0.4	-0.7	-0.6	0.3	0.7	-0.5	0.2	0.5	0.6
Bone: marrow area	1.0	2.1	2.8	-1.5	-1.6	-1.6	1.6	1.3	-1.1	1.1	1.7	1.5
Bone: maximum diameter	1.9	3.5	4.8	-1.8	-2.2	-1.9	1.7	2.1	-1.3	1.7	2.0	1.9
Bone: maximum force	0.4	0.8	1.2	-0.8	-0.9	-0.9	0.6	1.1	-1.0	0.7	0.8	0.9
Bone: maximum moment	0.5	0.8	1.3	-0.9	-1.0	-1.0	0.7	1.1	-1.0	0.7	0.9	0.9
Bone: minimum diameter	0.5	1.0	1.5	-0.9	-1.1	-1.0	1.2	0.8	-0.5	0.7	1.2	1.1
Bone: periosteal estimation	1.9	3.8	5.2	-2.0	-2.3	-2.1	2.0	1.8	-1.6	1.3	2.3	2.1
Bone: periosteal perimeter	1.8	3.0	5.8	-1.5	-1.7	-1.5	1.7	2.1	-1.0	2.4	1.8	1.6
Bone: post-yield work	0.0	0.0	0.0	-0.0	0.1	0.0	-0.1	0.1	-0.2	0.1	-0.1	-0.0
Bone: stiffness	0.0	0.1	0.2	0.3	-0.2	-0.1	-0.4	0.3	0.1	-0.0	-0.2	-0.0
Bone: tissue strength	2.4	2.3	3.7	1.4	1.3	1.4	-1.9	-1.2	1.2	-1.5	-1.8	-1.7
Bone: trabecular number	0.2	0.3	0.5	0.4	0.6	0.6	-0.7	-0.4	0.3	-0.4	-0.7	-0.7
Bone: trabecular spacing	0.4	0.5	1.0	-0.8	-0.6	-0.7	0.9	0.3	-1.0	0.0	0.8	0.9
Bone: trabecular thickness	0.4	0.4	2.6	0.2	-0.2	-0.2	0.1	1.0	0.4	1.6	0.2	0.2
Bone: trabecular tissue density	1.6	2.2	4.8	2.0	1.4	1.5	-1.4	-0.8	2.2	0.0	-1.6	-1.4
Breakpoint value in progressive ratio session	0.0	0.0	0.1	-0.2	-0.2	0.0	0.1	0.1	-0.4	-0.1	0.1	0.1
Distance traveled before self-admin	0.1	0.1	0.2	0.4	0.2	0.3	-0.3	-0.2	0.4	-0.1	-0.3	-0.2
Distance traveled after self-admin	1.4	1.6	2.2	1.5	1.5	1.3	-1.4	-1.0	1.1	-0.7	-1.5	-1.3
Delta time in closed arm before/after self-admin	1.8	1.7	7.1	-0.3	-0.7	-0.9	1.2	1.7	-0.3	2.7	0.9	1.2
Delta time in open arm before/after self-admin	0.9	0.9	1.5	-1.2	-1.2	-0.9	0.9	0.7	-0.9	0.0	1.2	0.9
Diff in mean of infusions in LGA sessions	2.6	2.9	4.6	2.0	1.5	1.9	-1.8	-1.1	2.2	-0.5	-2.0	-1.9
Extinction: sum of active levers before priming	0.4	0.4	0.6	-0.5	-0.7	-0.7	0.6	0.7	-0.3	0.7	0.6	0.6
Active lever presses in extinction session 6	0.2	0.2	0.7	-0.5	-0.3	0.0	0.2	-0.2	-0.8	-0.6	0.4	0.3
Delta distance traveled before/after self-admin	0.6	0.6	1.0	0.9	1.0	0.9	-0.8	-0.4	0.7	0.1	-0.9	-0.8
Delta ambulatory time before/after self-admin	0.4	0.5	0.8	0.9	0.9	0.8	-0.7	-0.0	0.5	0.5	-0.8	-0.6
Time in closed arm before self-admin	0.0	0.0	0.2	-0.1	0.2	0.3	-0.0	-0.1	-0.4	-0.2	-0.2	-0.1
Time in closed arm after self-admin	0.4	0.4	1.0	-0.4	0.1	0.0	0.6	0.7	-1.0	1.0	0.3	0.5
Time in open arm before self-admin	0.8	0.9	1.6	1.3	1.0	1.0	-0.8	-0.9	1.0	-0.4	-1.1	-0.8
Time in open arm after self-admin	0.1	0.1	0.4	0.1	-0.1	-0.1	-0.2	-0.2	0.6	-0.3	-0.0	-0.2
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.8	0.7	0.4	0.5	-0.7	-0.4	0.9	-0.3	-0.6	-0.6
Time to tail flick, vehicle, before self-admin	0.4	0.4	0.9	0.8	0.7	0.7	-0.4	-0.3	1.0	0.0	-0.6	-0.6
Time to tail flick, vehicle, after self-admin	1.9	2.1	2.6	-1.4	-0.8	-1.3	1.5	1.6	-1.6	1.6	1.4	1.5
Time to tail flick, test, before self-admin	1.0	1.0	1.1	-1.0	-1.0	-1.0	1.0	1.0	-0.9	1.0	1.0	1.0
Time to tail flick, test, after self-admin	1.9	2.0	2.8	-1.3	-1.1	-1.4	1.7	1.4	-1.2	1.4	1.5	1.6
Delta time to tail flick, vehicle, before/after SA	2.4	2.3	4.3	-1.7	-1.1	-1.5	1.5	1.4	-2.1	1.0	1.5	1.5
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	0.4	0.5	0.3	-0.3	-0.3	0.3	-0.2	-0.4	-0.3
Ambulatory time before self-admin	0.0	0.0	0.0	0.0	-0.1	0.0	-0.2	0.0	-0.1	0.0	-0.1	-0.1
Ambulatory time after self-admin	0.9	1.0	1.6	1.1	1.2	1.1	-1.2	-0.6	0.8	-0.2	-1.3	-1.1
Total heroin consumption	0.1	0.1	0.3	-0.0	-0.2	-0.3	0.0	0.5	-0.0	0.5	0.1	0.1
Area under the delay curve	0.9	0.9	1.3	-0.9	-0.8	-1.0	0.9	1.1	-1.0	1.2	0.9	0.9
Delay disc. indifference point, 0s delay	0.4	0.4	0.7	-0.9	-0.7	-0.8	0.6	0.1	-0.7	-0.3	0.8	0.7
Delay disc. indifference point, 16s delay	0.7	0.7	2.6	-0.4	-0.3	-0.6	0.7	1.2	-0.8	1.6	0.5	0.7
Delay disc. indifference point, 2s delay	0.6	0.6	1.2	-1.1	-1.0	-0.9	0.6	0.6	-0.8	0.3	0.9	0.7
Delay disc. indifference point, 24s delay	0.2	0.2	1.4	0.1	-0.0	-0.2	0.2	0.6	-0.1	1.2	-0.0	0.1
Delay disc. indifference point, 4s delay	1.6	1.6	2.3	-1.3	-1.5	-1.4	1.2	1.3	-0.9	1.1	1.4	1.2
Delay disc. indifference point, 8s delay	1.3	1.3	1.9	-1.0	-0.9	-1.1	1.2	1.3	-1.3	1.4	1.1	1.1
Delay discount exponential model param	0.8	0.9	1.4	0.8	0.8	0.9	-0.9	-1.1	1.0	-1.2	-0.9	-0.9
Delay discount hyperbolic model param	1.0	1.1	1.3	1.0	1.0	1.1	-1.0	-1.1	1.1	-1.1	-1.0	-1.0
Fecal boli incidents, locomotor time 1	3.1	3.4	7.3	-2.2	-1.3	-1.7	2.1	1.0	-2.7	0.0	2.1	2.1
Change in fecal boli incidents, locomotor task	2.3	2.2	3.3	1.8	1.5	1.6	-1.6	-0.8	1.7	0.1	-1.7	-1.6
Time >=10cm from walls, locomotor time 1	0.7	0.7	1.3	-1.0	-0.5	-0.8	0.9	0.8	-1.1	0.6	0.9	0.8
Bouts of movement, locomotor time 1	0.8	0.9	2.9	-0.6	-0.7	-0.8	0.7	1.4	-0.5	1.7	0.7	0.8
Total resting periods, locomotor time 1	0.6	0.6	2.4	-0.5	-0.6	-0.5	0.5	1.3	-0.5	1.6	0.5	0.5
Rest time, locomotor task time 1	0.4	0.5	1.1	-0.5	-0.4	-0.4	0.5	1.0	-0.8	1.1	0.4	0.6
Distance moved, locomotor task time 1	0.2	0.2	0.4	-0.4	-0.5	-0.5	0.5	-0.1	0.1	-0.2	0.6	0.4
Vertical activity count, locomotor time 1	0.1	0.1	0.4	-0.3	-0.4	-0.6	0.2	0.0	0.1	0.1	0.5	0.2
Time >=10cm from walls, locomotor time 2	1.0	1.1	1.8	-1.3	-1.0	-1.3	1.0	0.8	-0.9	0.4	1.2	1.0
Bouts of movement, locomotor time 2	0.0	0.1	0.1	-0.2	-0.3	-0.3	0.0	0.3	0.1	0.3	0.2	0.1
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.1	-0.2	-0.1	0.0	0.2	0.0	0.2	0.1	0.1
Rest time, locomotor task time 2	1.5	1.7	2.4	1.3	1.5	1.5	-1.2	-1.3	0.8	-1.4	-1.4	-1.2
Distance moved, locomotor task time 2	2.1	2.4	4.1	-1.9	-2.0	-1.9	1.5	1.0	-1.1	0.4	1.9	1.5
Vertical activity count, locomotor time 2	1.1	1.2	2.2	-1.3	-1.5	-1.4	1.1	0.6	-0.7	0.4	1.4	1.1
Weight adjusted by age	0.4	0.5	0.9	-0.9	-0.9	-0.9	0.7	0.2	-0.3	-0.1	0.9	0.7
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	1.2	0.1	0.0	0.1	-0.4	-0.6	0.2	-1.1	-0.3	-0.3
Locomotion in novel chamber	0.3	0.3	1.0	-0.9	-0.6	-0.6	0.3	0.4	-1.0	-0.1	0.4	0.3
Locomotion in novel chamber post-restriction	2.3	2.7	4.3	-2.0	-1.6	-1.5	1.4	1.8	-2.1	1.4	1.6	1.4
Progressive ratio	1.3	1.5	2.7	-1.0	-0.8	-1.1	1.3	1.2	-1.7	1.4	1.1	1.3
Food seeking constrained by brief footshock	0.7	0.8	1.6	-0.4	-0.5	-0.9	1.2	0.9	-0.4	1.3	0.9	1.1
Seeking ratio, punishment vs. effort	0.6	0.7	1.9	0.6	0.2	0.6	-0.7	-1.0	1.4	-1.3	-0.5	-0.6
Run reversals in cocaine runway, females	0.5	0.4	1.4	-0.1	-0.7	-0.6	0.7	0.6	0.4	1.2	0.6	0.6
Run reversals in cocaine runway, males	1.6	1.5	3.2	-1.1	-1.0	-1.1	0.9	1.6	-1.2	1.8	1.0	1.0
Latency to leave start box in cocaine runway	1.9	2.1	3.9	1.3	1.4	1.3	-1.1	-1.9	1.1	-2.0	-1.3	-1.2
Latency to leave start box in cocaine runway, F	1.0	1.1	3.8	0.7	0.9	0.9	-0.6	-1.7	0.5	-2.0	-0.7	-0.7
Latency to leave start box in cocaine runway, M	1.4	1.4	1.8	1.1	1.1	1.0	-1.2	-1.2	0.9	-1.3	-1.3	-1.2
Cd content in liver	0.1	0.2	0.3	0.6	0.4	0.4	-0.5	-0.5	0.1	-0.4	-0.1	-0.4
Co content in liver	1.5	1.8	2.8	-1.7	-1.5	-1.5	1.7	1.2	-0.4	1.1	1.2	1.5
Cu content in liver	0.6	0.8	1.4	-0.6	-0.8	-0.9	1.1	0.9	-0.1	1.2	0.9	1.0
Fe content in liver	0.5	0.6	0.9	-0.9	-0.9	-0.9	0.7	0.3	-0.7	-0.5	0.7	0.9
K content in liver	0.9	0.9	1.3	0.8	1.1	1.1	-0.8	-1.1	0.8	-0.7	-0.8	-1.1
Mg content in liver	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.2	0.1	-0.3	0.3	0.3	0.1
Mn content in liver	1.1	1.3	1.7	0.8	1.2	1.2	-1.2	-1.2	0.6	-1.3	-1.2	-1.2
Na content in liver	0.9	1.0	3.8	0.3	0.8	0.8	-0.8	-1.4	-0.1	-1.9	-0.6	-0.8
Rb content in liver	1.2	1.5	4.5	-0.8	-1.1	-1.1	1.1	1.7	-0.4	2.1	1.0	1.1
Se content in liver	2.6	3.2	5.4	1.6	2.0	1.9	-1.8	-2.3	-0.1	-2.3	-1.0	-1.9
Sr content in liver	0.7	0.6	1.2	-0.9	-0.7	-0.7	0.7	0.7	-1.1	0.5	0.9	0.7
Zn content in liver	2.1	2.3	3.2	-1.4	-1.5	-1.6	1.6	1.4	-1.5	1.2	1.8	1.6