Ndufc2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000012383	0.42	0.14	9.4e-16	0.09	0.11	0.1	0.08	4.1e-10	3.4e-12	1.6e-11	1.3e-09
2	Brain	gene expression	ENSRNOG00000012383	0.11	0.06	3.4e-10	0.08	0.11	0.12	0.12	3.8e-08	3.0e-10	8.5e-11	5.9e-11
3	Brain	mRNA stability	ENSRNOG00000012383	0.12	0.07	3.1e-10	0.11	0.11	0.09	0.1	1.8e-10	4.9e-10	5.0e-09	7.3e-10
4	Liver	gene expression	ENSRNOG00000012383	0.03	0.02	4.5e-03	0.02	0.01	0.01	0.02	1.7e-03	4.1e-02	2.2e-02	6.3e-03
5	PL	mRNA stability	ENSRNOG00000012383	0.04	0.03	9.5e-03	0.01	0.01	0	0	9.8e-02	5.9e-02	3.0e-01	1.5e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
BMI with tail	1.3	4.2	5.3	2.2	1.2	-2.3	2.1	-2.3
BMI without tail	6.9	14.4	18.0	4.2	1.6	-4.2	4.2	-4.1
Body weight	2.8	11.9	15.2	3.7	1.4	-3.9	3.6	-3.9
Epididymis fat weight	2.4	5.7	9.6	1.9	1.3	-3.1	2.9	-2.4
Glucose	0.3	0.4	0.6	-0.6	-0.5	0.7	-0.7	0.7
Heart weight	0.9	1.2	2.5	-1.0	-1.6	0.8	-1.1	0.9
Left kidney weight	0.6	1.6	2.5	1.6	-0.6	-1.3	1.4	-1.2
Right kidney weight	0.7	1.9	2.8	1.7	-0.1	-1.5	1.5	-1.5
Tail length	2.5	7.6	10.1	3.2	-0.3	-3.1	3.2	-2.9
Length with tail	2.1	7.7	10.1	3.2	0.6	-3.1	3.0	-3.1
Length without tail	0.1	0.2	0.6	0.3	0.8	-0.2	-0.0	-0.5
Liver weight, left	1.0	1.7	2.2	1.2	0.8	-1.5	1.4	-1.4
Liver weight, right	6.1	10.1	13.5	2.7	2.6	-3.7	3.6	-3.1
Parametrial fat weight	2.3	4.5	5.8	1.9	1.5	-2.4	2.3	-2.4
Retroperitoneal fat weight	7.2	23.7	29.7	4.9	2.9	-5.4	5.4	-5.2
Intraocular pressure	5.2	7.4	9.3	-2.4	-2.4	3.0	-3.0	2.7
Extensor digitorum longus weight	0.2	0.7	1.1	0.9	-0.3	-0.9	0.7	-1.0
Soleus weight	1.1	3.1	4.4	2.1	0.4	-1.8	2.0	-1.9
Tibialis anterior weight	0.2	0.8	1.2	0.9	0.3	-1.0	0.9	-1.1
Tibia length	0.8	2.3	2.8	-1.7	-1.4	1.5	-1.3	1.7
Number of licking bursts	2.3	2.8	4.0	1.2	2.0	-1.8	1.5	-1.7
Food consumed during 24 hour testing period	1.7	2.0	4.0	-0.6	-0.8	2.0	-1.6	1.5
Times rat made contact with spout	1.4	1.6	2.3	1.5	1.4	-1.0	1.0	-1.3
Mean time between licks in bursts	0.4	0.5	2.5	0.1	-1.6	-0.1	0.2	0.2
Mean num. licks in bursts	1.5	1.8	2.6	-0.8	-1.6	1.5	-1.2	1.3
Std. dev. time between licks in bursts	1.3	1.6	2.7	1.6	0.2	-1.3	1.4	-1.3
Water consumed over 24 hours	1.0	1.2	2.7	1.2	1.6	-0.6	0.7	-1.0
Indifference point 0 sec	0.5	0.8	2.9	-0.4	-1.7	0.5	-0.7	0.4
Indifference point AUC	0.1	0.1	0.5	-0.2	-0.7	-0.1	-0.0	0.1
Indifference point function ln k	0.3	0.5	1.2	-0.4	-0.2	1.1	-0.8	0.6
Indifference point function log k	0.3	0.5	1.2	-0.4	-0.2	1.1	-0.8	0.6
Delay discounting total patch changes 0 sec	0.5	0.9	2.8	-0.5	-1.7	0.6	-0.8	0.5
Delay discounting total patch changes 12 sec	0.2	0.3	1.1	-0.4	-1.0	-0.3	0.2	0.2
Delay discounting total patch changes 18 sec	0.5	0.7	3.0	-0.0	-1.7	0.3	-0.3	0.3
Delay discounting total patch changes 24 sec	0.3	0.3	1.5	-0.2	-1.2	-0.2	-0.1	0.3
Delay discounting total patch changes 6 sec	0.0	0.0	0.1	-0.0	-0.3	0.1	-0.3	-0.2
Delay discounting time to switch 0 sec	1.6	2.4	6.6	0.8	2.6	-1.4	1.2	-1.2
Delay discounting water rate 0 sec	1.5	2.4	5.1	-1.2	-2.3	1.4	-1.3	1.4
Delay discounting water rate 12 sec	1.1	1.7	2.9	-0.4	-1.7	1.6	-1.5	0.9
Delay discounting water rate 18 sec	0.5	0.6	1.5	-0.1	-1.2	0.9	-0.8	0.3
Delay discounting water rate 24 sec	1.6	2.2	3.9	-1.0	-1.0	1.8	-2.0	1.3
Delay discounting water rate 6 sec	0.8	1.2	2.2	-0.6	-0.9	1.5	-1.3	1.0
Locomotor activity	0.9	1.5	3.6	1.9	0.4	-0.8	1.0	-1.4
Locomotor testing distance	0.6	1.0	1.7	1.3	-1.1	-0.7	0.8	-0.9
Locomotor testing rearing	2.0	3.2	4.3	2.0	-0.1	-2.1	2.0	-1.9
Light reinforcement 1	1.5	2.7	3.8	1.0	1.8	-2.0	1.8	-1.6
Light reinforcement 2	0.1	0.2	0.3	-0.3	0.6	-0.3	0.5	-0.0
Reaction time number correct	0.2	0.2	0.7	0.5	0.9	0.1	0.2	-0.3
Reaction time mean minus median	0.2	0.3	0.5	0.7	-0.5	-0.3	0.5	-0.5
Reaction time mean minus median AUC	0.1	0.1	0.2	0.4	-0.5	0.1	0.1	-0.2
Reaction time num false alarms	0.7	1.0	1.2	1.0	1.0	-1.1	0.9	-1.0
Reaction time num false alarms AUC	0.1	0.1	0.3	0.3	0.6	-0.3	0.1	-0.2
Reaction time trials correct on left	0.2	0.2	0.7	0.5	0.9	0.1	0.2	-0.3
Reaction time trials on left	0.2	0.2	0.7	0.5	0.8	0.1	0.2	-0.3
Reaction time mean	0.5	0.6	1.4	0.2	0.6	-1.2	1.0	-0.7
Reaction time mean AUC	0.3	0.4	0.8	-0.0	0.6	-0.9	0.7	-0.5
Median of all reaction times	0.3	0.5	1.0	-0.3	0.7	-1.0	0.7	-0.4
Reaction time omissions	0.1	0.2	0.4	-0.1	-0.4	-0.6	0.3	-0.4
Reaction time false alarm rate	0.0	0.0	0.1	-0.2	0.2	-0.4	0.0	0.0
Reaction time premature initiation rate	1.9	2.6	4.3	1.4	-0.2	-2.1	2.0	-1.6
Reaction time premature initiations	1.3	1.8	2.9	1.3	0.1	-1.6	1.7	-1.4
Std. dev. reaction times	0.5	0.7	0.9	0.8	-0.4	-0.9	0.9	-0.9
Reaction time trials completed	0.2	0.2	0.7	0.5	0.8	0.1	0.2	-0.3
Reaction time trials AUC	0.2	0.3	0.6	0.6	0.8	-0.1	0.4	-0.5
Social response proportion	2.2	2.4	3.4	1.2	1.8	-1.6	1.7	-1.4
Social responses	2.8	3.7	4.7	1.9	1.4	-2.2	1.9	-2.1
Social time	1.3	1.7	2.9	0.6	1.7	-1.4	1.3	-1.2
Conditioned locomotion	0.1	0.1	0.2	0.1	0.2	0.4	-0.5	0.0
Cocaine response after cond. corrected	0.2	0.2	0.8	-0.9	-0.4	-0.3	-0.1	0.3
Cocaine response after cond. not corrected	0.5	0.5	1.9	-1.4	-0.3	-0.0	-0.4	0.7
Cocaine response before conditioning	0.2	0.2	0.6	-0.5	0.8	0.3	-0.1	0.4
Saline control response	0.3	0.4	1.0	0.8	-1.0	-0.3	0.2	-0.6
Condit. Reinf. active minus inactive responses	1.7	2.1	8.8	-0.7	-3.0	0.5	-0.4	0.7
Condit. Reinf. active-inactive response ratio	1.5	1.5	4.7	-0.8	-2.2	0.9	-0.8	0.9
Condit. Reinf. active responses	1.6	2.2	10.4	-0.4	-3.2	0.2	-0.2	0.4
Condit. Reinf. inactive responses	0.6	0.7	1.0	0.9	-1.0	-0.8	0.8	-0.7
Condit. Reinf. lever presses	5.6	7.6	19.7	-1.8	-4.4	2.3	-2.4	2.1
Condit. Reinf. lever reinforcers received	2.0	2.8	12.3	-0.8	-3.5	0.4	-0.5	0.8
Pavlov. Cond. lever latency	8.4	11.5	27.1	2.4	5.2	-2.9	3.0	-2.7
Pavlov. Cond. magazine entry latency	5.6	6.5	10.4	-2.2	-3.2	2.5	-2.4	2.2
Pavlov. Cond. change in total contacts	4.9	6.9	16.9	-1.9	-4.1	2.1	-2.2	2.0
Pavlov. Cond. index score	8.1	10.5	23.1	-2.5	-4.8	2.8	-2.9	2.7
Pavlov. Cond. latency score	8.0	10.1	21.1	-2.5	-4.6	2.8	-2.9	2.6
Pavlov. Cond. lever contacts	7.1	9.8	24.4	-2.1	-4.9	2.7	-2.8	2.3
Pavlov. Cond. magazine entry number	10.9	13.4	22.9	3.1	4.8	-3.4	3.4	-3.3
Pavlov. Cond. intertrial magazine entries	3.4	4.4	6.1	2.3	1.2	-2.2	2.5	-2.1
Pavlov. Cond. lever-magazine prob. diff.	7.4	9.6	21.8	-2.4	-4.7	2.6	-2.7	2.5
Pavlov. Cond. response bias	9.0	12.5	28.4	-2.7	-5.3	3.0	-3.1	2.9
Conditioned reinforcement - actives	5.0	5.0	7.2	-2.7	-1.6	2.1	-1.9	2.6
Conditioned reinforcement - inactives	0.2	0.2	0.4	-0.6	0.6	0.1	-0.3	0.3
Conditioned locomotion	4.0	4.8	6.8	-2.6	-1.3	2.2	-2.1	2.6
Intermittent access intake day 1-15 change	2.6	2.6	3.1	-1.6	-1.2	1.6	-1.8	1.7
Intermittent access intake escalation	2.9	2.9	3.4	-1.7	-1.5	1.7	-1.9	1.8
Intermittent access intake escalation 2	0.4	0.4	0.7	-0.9	-0.5	0.4	-0.5	0.8
Intermitt. access day 1 inactive lever presses	0.4	0.4	1.3	-0.2	1.1	-0.7	0.5	-0.2
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.2	-0.4	0.3	0.1	-0.3	0.1
Intermitt. access escalation Index	0.3	0.2	0.8	0.4	0.9	-0.1	0.2	-0.4
Intermittent access day 1 total infusions	0.8	1.0	1.5	-0.9	-1.2	1.0	-0.8	1.0
Intermittent access day 15 total infusions	4.1	4.6	5.1	-2.2	-1.8	2.2	-2.2	2.3
Intermittent access terminal intake (last 3 days)	2.0	2.1	2.8	-1.7	-1.2	1.4	-1.3	1.6
Intermittent access total infusions	1.5	1.6	2.6	-1.6	-1.0	1.1	-1.0	1.5
Intermittent access day 1 locomotion	1.0	1.0	1.6	-1.3	-0.1	1.0	-0.8	1.2
Intermittent access day 15 total locomotion	1.5	1.6	1.9	-1.3	-1.2	1.2	-1.1	1.4
Intermittent access total locomotion	0.7	0.7	1.2	-1.1	-0.7	0.7	-0.6	1.1
Intermittent access standard deviation	0.1	0.1	0.3	-0.6	0.1	-0.2	-0.1	0.3
Cocaine induced anxiety	1.0	1.2	1.8	1.1	1.3	-0.7	1.1	-1.1
Post-drug Anxiety	0.1	0.2	0.3	0.5	0.2	-0.2	0.3	-0.5
Baseline Anxiety	2.0	2.2	3.7	-1.2	-1.9	1.3	-1.5	1.3
Lifetime Intake	1.8	2.0	3.0	-1.7	-1.3	1.3	-1.1	1.6
Incentive Sensitization - Responses	1.2	1.2	2.7	-1.2	-1.7	0.4	-0.8	1.0
Incentive Sensitization - Breakpoint	1.2	1.2	2.3	-1.2	-1.5	0.5	-0.8	1.0
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	-0.4	0.5	0.3	-0.1	0.3
Progressive ratio test 1 breakpoint	0.1	0.1	0.3	-0.4	0.6	0.2	0.0	0.3
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.2	-0.4	-0.1	0.1	-0.1	0.3
Progressive ratio test 2 active lever presses	1.3	1.4	2.3	-1.4	-1.5	0.8	-0.8	1.2
Progressive ratio test 2 breakpoint	0.8	0.9	1.5	-1.1	-1.2	0.5	-0.6	1.0
Progressive ratio test 2 inactive lever presses	0.7	0.8	1.3	-1.1	-1.1	0.6	-0.6	0.9
Total sessions with >9 infusions	1.4	1.6	2.6	-1.6	-0.8	1.3	-1.0	1.4
Short access day 1 total inactive lever presses	0.4	0.5	0.8	-0.9	-0.5	0.6	-0.7	0.7
Short access day 10 total inactive lever presses	1.3	1.5	2.8	0.9	1.7	-1.1	0.9	-1.2
Short access day 1 total infusions	1.2	1.2	2.1	-1.4	-1.2	0.8	-0.7	1.2
Short access day 10 total infusions	1.2	1.4	2.2	-1.3	-1.5	1.0	-0.7	1.3
Short access total infusions	0.8	0.9	1.6	-1.3	-0.9	0.7	-0.5	1.1
Short access day 1 locomotion	3.9	4.1	5.2	-2.3	-1.4	2.1	-2.2	2.1
Short access day 10 total locomotion	0.1	0.1	0.1	-0.2	-0.2	0.3	-0.1	0.4
Short access total locomotion	0.3	0.3	0.7	-0.9	0.3	0.3	-0.1	0.7
Compulsive drug intake	0.0	0.0	0.1	-0.2	0.2	-0.1	0.1	0.1
One hour access (0.3 mA shock)	1.3	1.5	2.9	-1.3	-1.7	0.8	-0.9	1.2
One hour access (shock baseline)	1.0	1.1	1.7	-1.0	-1.3	0.9	-1.0	1.1
Number of responses in last shaping day	0.7	0.7	1.8	0.0	0.0	-1.4	1.1	-0.5
Context. condit. distance diff. score	4.3	5.3	6.2	-2.5	-2.2	2.1	-2.2	2.5
Locomotion velocity, session 1	1.5	1.6	2.1	-1.2	-0.7	1.5	-1.4	1.4
Locomotion distance, session 1	0.8	1.0	1.6	-1.2	-1.0	0.8	-0.9	1.1
Locomotion velocity, session 2	0.5	0.6	0.9	-0.4	-1.0	0.9	-0.8	0.8
Locomotion distance, session 2	0.1	0.1	0.3	0.5	-0.0	-0.1	0.0	-0.3
Locomotion velocity, session 3	0.3	0.4	0.5	-0.5	-0.7	0.7	-0.6	0.7
Locomotion distance, session 3	3.1	3.4	3.9	-1.8	-1.8	2.0	-1.7	2.0
Stereotopy head waving bouts, day 3	3.2	3.9	5.6	1.8	2.4	-1.9	1.9	-1.8
Stereotopy head waving duration, day 3	0.3	0.4	0.8	0.9	0.8	-0.2	0.1	-0.7
Locomotion velocity, session 7	0.5	0.5	0.7	-0.7	-0.7	0.8	-0.5	0.8
Locomotion distance, session 7	0.8	1.0	2.1	-1.1	-1.4	0.7	-0.5	0.9
Stereotopy head waving bouts, day 7	0.3	0.3	0.4	-0.5	0.2	0.7	-0.6	0.7
Stereotopy head waving duration, day 7	0.2	0.3	0.5	-0.2	-0.4	0.7	-0.6	0.5
Locomotion velocity, session 8	7.5	9.0	10.5	-2.5	-3.0	3.2	-3.1	3.0
Locomotion distance, session 8	1.7	2.5	2.8	-1.5	-1.7	1.5	-1.6	1.6
Degree of sensitization distance	1.4	1.4	2.4	1.0	0.1	-1.5	1.5	-1.3
Degree of sensitization stereotypy	3.0	3.2	4.0	-1.8	-1.2	2.0	-1.8	2.0
Condit. Reinf. active minus inactive responses	0.9	1.0	1.7	1.0	-0.4	-1.0	1.3	-1.1
Condit. Reinf. active-inactive response ratio	1.0	1.1	1.8	1.0	-0.2	-1.2	1.3	-1.1
Condit. Reinf. active responses	0.8	1.0	1.7	1.2	-0.0	-0.9	1.3	-1.1
Condit. Reinf. inactive responses	0.0	0.0	0.2	0.4	0.1	0.0	0.2	-0.1
Incentive salience index mean	0.3	0.4	0.7	0.5	-0.9	-0.5	0.7	-0.4
Condit. Reinf. lever presses	0.5	0.6	1.5	-0.3	-1.2	0.8	-0.6	0.8
Time in familiar zone, hab. session 1	0.0	0.0	0.1	-0.2	-0.1	0.2	-0.2	0.3
Time in novel zone, hab. session 1	0.8	0.8	1.1	0.9	0.4	-1.0	0.9	-1.0
Total zone transitions, hab. session 1	0.1	0.1	0.5	0.2	0.7	0.2	-0.2	-0.2
Total locomotion distance, hab. session 1	6.8	9.7	12.7	2.5	2.9	-3.6	3.5	-3.0
Locomotion velocity, hab. session 1	5.6	8.0	10.8	2.1	2.7	-3.3	3.2	-2.7
Time in familiar zone, hab. session 2	0.3	0.3	0.7	0.5	-0.9	0.5	-0.5	0.1
Time in novel zone, hab. session 2	0.3	0.3	1.0	-1.0	-0.3	-0.0	-0.0	0.5
Total zone transitions, hab. session 2	0.0	0.0	0.1	-0.1	0.0	0.3	-0.3	-0.1
Total locomotion distance, hab. session 2	4.8	6.3	9.0	2.1	1.8	-3.0	2.9	-2.6
Locomotion velocity, hab. session 2	5.4	7.3	10.1	2.4	1.9	-3.2	3.0	-2.9
Novel to familiar place preference ratio	0.1	0.1	0.3	-0.2	0.6	-0.3	0.3	-0.2
Novelty place preference	0.0	0.0	0.1	-0.2	0.4	-0.2	0.1	-0.1
Time in novel zone, NPP test	0.0	0.0	0.1	-0.3	0.1	0.1	-0.1	0.1
Total zone transitions, NPP test	0.6	0.8	1.4	-0.9	-0.6	1.0	-1.2	0.8
Total locomotion distance, NPP test	2.5	3.5	6.3	1.0	1.3	-2.5	2.4	-1.7
Locomotion velocity, NPP test	3.2	4.5	7.9	1.1	1.7	-2.8	2.6	-1.9
Pavlov. Cond. lever latency	0.6	0.7	1.7	0.5	1.3	-0.7	0.6	-0.9
Pavlov. Cond. magazine entry latency	0.5	0.6	2.7	-0.5	-1.6	0.3	-0.1	0.5
Pavlov. Cond. change in total contacts	1.3	1.3	2.6	-1.3	-1.6	0.7	-0.5	1.3
Pavlov. Cond. index score	0.7	0.9	3.6	-0.4	-1.9	0.5	-0.2	0.7
Pavlov. Cond. latency score	0.6	0.8	3.0	-0.5	-1.7	0.4	-0.3	0.7
Pavlov. Cond. lever contacts	0.5	0.6	2.1	-0.2	-1.4	0.5	-0.3	0.7
Pavlov. Cond. magazine entry number	0.7	0.9	3.6	0.5	1.9	-0.5	0.3	-0.6
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.1	0.8	1.0	-0.7	0.8	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	3.1	-0.4	-1.8	0.6	-0.3	0.8
Pavlov. Cond. response bias	0.3	0.3	1.4	0.0	-1.2	0.2	0.1	0.3
Bone: apparent density	0.1	0.1	0.2	-0.1	0.2	0.5	-0.5	0.3
Bone surface	1.2	2.1	3.3	-1.3	-1.8	1.3	-1.4	1.4
Bone volume	0.6	0.9	1.9	-0.5	-1.4	0.9	-1.0	0.8
Bone: connectivity density	1.1	1.7	2.3	-1.5	-0.5	1.5	-1.3	1.5
Bone: cortical apparent density	0.4	0.5	1.0	1.0	0.6	-0.6	0.4	-0.8
Bone: cortical area	0.2	0.3	1.2	-0.3	-1.1	-0.2	0.3	0.1
Bone: cortical porosity	0.1	0.1	0.3	-0.5	0.4	0.3	-0.2	0.3
Bone: cortical porosity	0.1	0.1	0.3	-0.5	0.5	0.2	-0.0	0.3
Bone: cortical thickness	0.1	0.2	0.4	-0.0	0.2	-0.5	0.6	-0.3
Bone: cortical thickness	1.6	1.9	3.8	-2.0	-1.6	0.8	-0.7	1.4
Bone: cortical tissue density	0.4	0.5	1.0	1.0	0.7	-0.5	0.4	-0.8
Bone: elastic displacement	0.1	0.1	0.4	-0.2	0.6	0.1	-0.1	-0.0
Bone: elastic work	0.4	0.5	0.8	-0.8	0.5	0.9	-0.7	0.6
Bone: endosteal estimation	0.3	0.7	3.1	0.0	-1.8	0.2	-0.1	0.3
Bone: endosteal perimeter	0.9	1.9	5.8	-0.4	-2.4	1.1	-1.2	0.9
Bone: final force	0.3	0.5	1.1	-1.0	-0.6	0.6	-0.6	0.7
Bone: final moment	0.3	0.5	0.8	-0.9	-0.6	0.6	-0.5	0.7
Bone: marrow area	0.2	0.5	2.5	0.1	-1.6	0.1	-0.0	0.2
Bone: maximum diameter	0.6	1.1	3.7	-0.6	-1.9	0.6	-0.6	0.7
Bone: maximum force	0.7	1.2	1.6	-1.3	-1.0	1.1	-1.0	1.1
Bone: maximum moment	0.7	1.2	1.3	-1.2	-1.1	1.1	-1.0	1.1
Bone: minimum diameter	0.4	0.7	1.1	0.8	-1.0	-0.8	0.9	-0.6
Bone: periosteal estimation	0.6	1.2	4.7	-0.6	-2.2	0.4	-0.3	0.7
Bone: periosteal perimeter	0.4	0.6	2.4	0.5	-1.5	0.5	-0.4	0.1
Bone: post-yield work	0.1	0.1	0.4	-0.2	-0.0	0.4	-0.6	0.4
Bone: stiffness	0.1	0.1	0.3	-0.6	-0.0	0.0	-0.2	0.2
Bone: tissue strength	0.6	0.6	2.5	-0.5	1.6	0.2	-0.1	0.2
Bone: trabecular number	0.1	0.2	0.4	-0.3	0.6	0.5	-0.5	0.4
Bone: trabecular spacing	0.3	0.4	0.8	-0.7	-0.9	0.5	-0.4	0.7
Bone: trabecular thickness	0.4	0.5	1.4	1.2	-0.1	-0.4	0.5	-0.9
Bone: trabecular tissue density	3.7	5.2	6.5	2.5	1.7	-2.3	2.2	-2.6
Breakpoint value in progressive ratio session	0.3	0.4	0.6	-0.7	-0.0	0.5	-0.8	0.7
Distance traveled before self-admin	0.1	0.1	0.1	0.2	0.3	-0.3	0.3	-0.3
Distance traveled after self-admin	0.5	0.5	1.8	0.5	1.3	-0.4	0.4	-0.6
Delta time in closed arm before/after self-admin	0.9	0.9	2.1	1.4	-0.9	-0.3	0.4	-1.0
Delta time in open arm before/after self-admin	0.6	0.5	0.9	-0.8	-1.0	0.3	-0.6	0.8
Diff in mean of infusions in LGA sessions	2.6	2.9	4.5	1.6	2.1	-1.6	1.4	-1.7
Extinction: sum of active levers before priming	0.1	0.1	0.4	0.2	-0.7	-0.2	-0.0	-0.1
Active lever presses in extinction session 6	0.9	0.9	1.8	-1.3	-0.3	0.5	-1.1	1.1
Delta distance traveled before/after self-admin	0.3	0.3	0.8	0.7	0.9	-0.3	0.2	-0.6
Delta ambulatory time before/after self-admin	0.2	0.2	0.5	0.4	0.7	0.2	-0.3	-0.2
Time in closed arm before self-admin	0.8	0.9	1.2	-1.0	0.2	1.0	-1.1	1.0
Time in closed arm after self-admin	1.5	1.6	3.0	-1.0	-0.3	1.7	-1.6	1.2
Time in open arm before self-admin	1.4	1.4	1.7	1.2	1.0	-1.3	1.3	-1.2
Time in open arm after self-admin	0.8	0.9	1.5	0.9	0.1	-1.2	1.1	-0.9
Sum of active levers in priming session hrs 5-6	0.6	0.6	0.9	0.7	0.7	-0.9	0.6	-0.8
Time to tail flick, vehicle, before self-admin	0.9	0.9	1.1	1.0	0.8	-1.0	0.8	-1.0
Time to tail flick, vehicle, after self-admin	1.7	1.9	2.5	-0.8	-1.6	1.5	-1.6	1.2
Time to tail flick, test, before self-admin	0.5	0.5	1.1	-0.4	-1.1	0.7	-0.6	0.6
Time to tail flick, test, after self-admin	0.5	0.6	2.4	-0.0	-1.6	0.5	-0.3	0.3
Delta time to tail flick, vehicle, before/after SA	4.2	4.1	5.0	-1.9	-1.8	2.2	-2.2	2.0
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	0.3	0.3	-0.3	0.3	-0.4
Ambulatory time before self-admin	0.2	0.2	0.2	-0.5	0.1	0.5	-0.4	0.4
Ambulatory time after self-admin	0.3	0.3	1.2	0.1	1.1	0.3	-0.3	-0.1
Total heroin consumption	0.1	0.1	0.3	-0.1	-0.2	0.1	-0.5	0.1
Area under the delay curve	0.9	1.0	1.3	-0.7	-1.1	1.1	-1.1	0.8
Delay disc. indifference point, 0s delay	0.2	0.2	0.6	-0.5	-0.8	0.1	-0.1	0.5
Delay disc. indifference point, 16s delay	0.8	0.8	1.5	-0.4	-0.7	1.2	-1.2	0.6
Delay disc. indifference point, 2s delay	0.7	0.8	0.9	-0.9	-0.8	0.9	-0.8	0.9
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.2	-0.2	0.5	-0.5	-0.0
Delay disc. indifference point, 4s delay	0.6	0.6	1.7	-0.5	-1.3	0.6	-0.6	0.6
Delay disc. indifference point, 8s delay	1.3	1.3	1.7	-0.8	-1.3	1.3	-1.3	1.0
Delay discount exponential model param	0.9	0.9	1.3	0.7	1.0	-1.1	1.1	-0.8
Delay discount hyperbolic model param	1.0	1.0	1.3	0.8	1.1	-1.1	1.1	-0.9
Fecal boli incidents, locomotor time 1	4.3	4.7	5.8	-2.4	-2.2	1.9	-1.9	2.4
Change in fecal boli incidents, locomotor task	2.2	2.1	2.9	1.6	1.7	-1.1	1.2	-1.6
Time >=10cm from walls, locomotor time 1	1.5	1.5	1.7	-1.2	-0.9	1.3	-1.3	1.3
Bouts of movement, locomotor time 1	0.3	0.3	0.6	0.0	-0.8	0.7	-0.7	0.2
Total resting periods, locomotor time 1	0.4	0.5	1.0	-0.2	-0.5	1.0	-1.0	0.4
Rest time, locomotor task time 1	0.8	0.8	1.5	-0.7	-0.5	1.1	-1.2	0.8
Distance moved, locomotor task time 1	0.4	0.5	0.9	0.5	-0.4	-0.9	0.9	-0.5
Vertical activity count, locomotor time 1	0.2	0.2	0.4	0.4	-0.4	-0.5	0.7	-0.4
Time >=10cm from walls, locomotor time 2	0.6	0.6	1.6	-0.7	-1.3	0.5	-0.5	0.7
Bouts of movement, locomotor time 2	0.1	0.1	0.1	0.4	-0.1	-0.2	0.3	-0.3
Total resting periods, locomotor time 2	0.0	0.0	0.1	0.2	-0.1	-0.1	0.2	-0.2
Rest time, locomotor task time 2	0.5	0.5	1.8	0.2	1.4	-0.6	0.5	-0.4
Distance moved, locomotor task time 2	0.8	0.9	3.1	-0.7	-1.8	0.4	-0.3	0.7
Vertical activity count, locomotor time 2	0.3	0.3	1.6	-0.1	-1.3	-0.1	0.2	0.2
Weight adjusted by age	0.3	0.4	0.7	0.3	-0.8	-0.6	0.8	-0.2
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.5	-0.7	0.2	-0.1	-0.2	0.3
Locomotion in novel chamber	1.7	2.1	4.0	-1.4	-0.6	2.0	-1.2	1.7
Locomotion in novel chamber post-restriction	4.9	5.8	8.9	-2.1	-1.7	3.0	-2.5	2.5
Progressive ratio	1.8	2.1	2.8	-1.2	-1.4	1.7	-1.5	1.4
Food seeking constrained by brief footshock	0.5	0.6	1.0	0.8	-1.0	-0.7	0.7	-0.7
Seeking ratio, punishment vs. effort	2.2	2.7	5.0	1.3	0.8	-2.2	1.9	-1.6
Run reversals in cocaine runway, females	2.1	2.0	2.9	1.7	-0.4	-1.5	1.5	-1.6
Run reversals in cocaine runway, males	2.0	1.9	3.1	-1.0	-1.2	1.6	-1.8	1.2
Latency to leave start box in cocaine runway	1.2	1.3	2.1	0.5	1.3	-1.4	1.3	-0.9
Latency to leave start box in cocaine runway, F	0.9	1.0	2.2	0.3	0.7	-1.5	1.4	-0.7
Latency to leave start box in cocaine runway, M	0.3	0.3	1.4	-0.0	1.2	-0.3	0.1	-0.2
Cd content in liver	0.5	0.5	0.8	0.6	0.1	-0.9	0.8	-0.8
Co content in liver	0.3	0.3	1.1	-0.0	-1.1	0.5	-0.2	0.4
Cu content in liver	0.5	0.6	1.0	1.0	-0.8	-0.6	0.7	-0.8
Fe content in liver	0.6	0.7	1.5	-1.2	-0.8	0.5	-0.4	0.9
K content in liver	0.9	0.9	1.4	1.2	1.0	-0.8	0.9	-0.9
Mg content in liver	0.0	0.0	0.1	0.2	-0.2	-0.1	-0.0	-0.1
Mn content in liver	0.3	0.4	1.4	-0.4	1.2	0.2	-0.4	0.2
Na content in liver	0.3	0.3	0.7	-0.8	0.6	0.3	-0.2	0.6
Rb content in liver	0.2	0.3	0.9	0.5	-1.0	0.1	-0.2	-0.2
Se content in liver	0.4	0.5	1.2	0.3	1.1	-0.6	0.7	-0.5
Sr content in liver	1.0	0.9	1.1	-0.9	-0.9	1.1	-1.0	1.0
Zn content in liver	0.7	0.7	3.2	-0.3	-1.8	0.3	-0.3	0.4