Hub : Genes

Dbnl

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression ENSRNOG00000012378 0.14 0.1 7.1e-03 0.03 0.04 -0.01 0.01 6.5e-02 5.0e-02 6.1e-01 1.4e-01
2 IL mRNA stability ENSRNOG00000012378 0.41 0.19 1.9e-06 0.17 0.14 0.15 0.14 6.4e-05 3.0e-04 1.6e-04 2.8e-04
3 Liver gene expression ENSRNOG00000012378 0.15 0.07 0.0e+00 0.17 0.19 0.19 0.2 1.3e-18 7.3e-21 3.3e-20 3.2e-21
4 Liver mRNA stability ENSRNOG00000012378 0.17 0.08 0.0e+00 0.22 0.2 0.21 0.21 1.1e-23 2.6e-22 1.9e-22 6.7e-23

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
BMI with tail0.00.00.10.1-0.2-0.10.2
BMI without tail0.00.10.3-0.1-0.60.10.1
Body weight1.35.46.52.42.0-2.52.3
Epididymis fat weight0.30.80.9-0.9-0.80.8-1.0
Glucose16.725.630.75.05.5-4.65.0
Heart weight0.20.20.4-0.6-0.40.6-0.3
Left kidney weight0.00.10.2-0.3-0.50.3-0.4
Right kidney weight1.02.83.9-1.6-2.01.5-1.6
Tail length1.23.54.21.91.5-2.02.0
Length with tail1.96.98.32.72.4-2.92.5
Length without tail1.22.63.01.71.7-1.71.3
Liver weight, left2.54.14.9-1.9-2.21.9-2.0
Liver weight, right4.47.49.0-2.6-2.82.4-3.0
Parametrial fat weight1.83.53.81.91.9-1.81.8
Retroperitoneal fat weight0.00.00.00.1-0.1-0.0-0.0
Intraocular pressure0.40.50.60.70.8-0.60.7
Extensor digitorum longus weight3.313.313.73.73.6-3.73.6
Soleus weight0.51.52.31.40.9-1.51.1
Tibialis anterior weight1.14.04.32.01.9-1.92.1
Tibia length0.10.30.7-0.4-0.80.2-0.6
Number of licking bursts3.03.64.01.91.9-2.01.8
Food consumed during 24 hour testing period2.42.83.31.61.8-1.61.7
Times rat made contact with spout0.00.10.2-0.00.40.00.2
Mean time between licks in bursts0.40.50.60.70.8-0.70.7
Mean num. licks in bursts2.02.42.9-1.6-1.41.7-1.4
Std. dev. time between licks in bursts0.00.00.00.10.1-0.10.2
Water consumed over 24 hours1.61.82.31.31.5-1.31.3
Indifference point 0 sec1.93.04.01.71.5-1.72.0
Indifference point AUC0.20.20.40.40.6-0.30.4
Indifference point function ln k0.00.00.00.0-0.1-0.1-0.1
Indifference point function log k0.00.00.00.0-0.1-0.1-0.1
Delay discounting total patch changes 0 sec2.03.24.31.81.6-1.72.1
Delay discounting total patch changes 12 sec1.11.52.01.21.1-1.21.4
Delay discounting total patch changes 18 sec1.92.53.11.61.6-1.41.8
Delay discounting total patch changes 24 sec0.70.91.3-1.0-1.11.1-0.5
Delay discounting total patch changes 6 sec2.33.54.41.81.8-1.82.1
Delay discounting time to switch 0 sec0.61.01.3-0.9-1.20.9-0.9
Delay discounting water rate 0 sec2.23.54.01.81.9-1.82.0
Delay discounting water rate 12 sec0.10.20.30.40.3-0.40.5
Delay discounting water rate 18 sec0.10.10.4-0.2-0.70.1-0.3
Delay discounting water rate 24 sec0.00.10.10.20.2-0.20.2
Delay discounting water rate 6 sec0.30.50.60.70.7-0.70.5
Locomotor activity0.40.70.90.80.9-0.60.9
Locomotor testing distance0.10.10.20.40.2-0.40.5
Locomotor testing rearing1.82.83.01.71.7-1.61.7
Light reinforcement 10.10.20.20.40.4-0.40.4
Light reinforcement 20.00.00.00.2-0.1-0.2-0.1
Reaction time number correct0.10.10.20.30.4-0.10.3
Reaction time mean minus median1.62.12.9-1.5-1.11.7-1.4
Reaction time mean minus median AUC1.41.82.3-1.4-1.01.5-1.3
Reaction time num false alarms0.50.71.00.80.5-1.00.9
Reaction time num false alarms AUC0.40.50.80.70.3-0.90.8
Reaction time trials correct on left0.10.10.20.30.4-0.10.3
Reaction time trials on left0.00.10.10.20.4-0.00.3
Reaction time mean0.91.21.4-1.1-1.21.2-1.0
Reaction time mean AUC1.52.02.2-1.4-1.41.5-1.3
Median of all reaction times0.50.71.0-0.8-1.00.8-0.7
Reaction time omissions1.11.51.8-1.3-1.41.3-1.0
Reaction time false alarm rate0.20.30.70.50.2-0.80.6
Reaction time premature initiation rate2.63.53.9-1.9-1.71.8-2.0
Reaction time premature initiations1.21.71.9-1.4-1.01.4-1.4
Std. dev. reaction times1.41.92.3-1.4-1.31.5-1.3
Reaction time trials completed0.00.10.10.20.4-0.00.3
Reaction time trials AUC0.10.10.20.30.5-0.20.4
Social response proportion2.02.22.71.51.6-1.61.2
Social responses2.83.64.01.92.0-1.81.9
Social time0.40.50.60.70.6-0.70.8
Conditioned locomotion0.91.01.6-1.0-1.30.8-1.0
Cocaine response after cond. corrected1.41.51.71.31.3-1.31.1
Cocaine response after cond. not corrected1.41.61.81.31.3-1.31.1
Cocaine response before conditioning0.30.40.5-0.6-0.60.6-0.7
Saline control response0.30.40.5-0.7-0.50.7-0.5
Condit. Reinf. active minus inactive responses0.40.50.6-0.7-0.60.8-0.6
Condit. Reinf. active-inactive response ratio0.00.00.00.0-0.10.00.1
Condit. Reinf. active responses0.50.70.9-0.9-0.71.0-0.9
Condit. Reinf. inactive responses0.81.01.3-1.1-0.81.1-1.1
Condit. Reinf. lever presses0.30.50.6-0.7-0.50.8-0.7
Condit. Reinf. lever reinforcers received0.40.50.7-0.7-0.60.8-0.8
Pavlov. Cond. lever latency3.34.55.42.21.9-2.31.9
Pavlov. Cond. magazine entry latency0.00.00.1-0.10.20.0-0.1
Pavlov. Cond. change in total contacts0.30.40.4-0.6-0.60.6-0.6
Pavlov. Cond. index score1.21.51.8-1.3-1.01.3-1.2
Pavlov. Cond. latency score1.21.51.7-1.3-1.11.3-1.2
Pavlov. Cond. lever contacts2.94.15.0-2.1-1.82.2-1.9
Pavlov. Cond. magazine entry number0.00.00.00.1-0.2-0.2-0.0
Pavlov. Cond. intertrial magazine entries0.00.00.00.1-0.0-0.10.1
Pavlov. Cond. lever-magazine prob. diff.1.11.51.7-1.3-1.01.3-1.2
Pavlov. Cond. response bias1.21.62.2-1.4-1.01.5-1.2
Conditioned reinforcement - actives0.00.00.0-0.0-0.10.1-0.0
Conditioned reinforcement - inactives0.00.00.00.20.2-0.20.2
Conditioned locomotion0.00.00.00.1-0.1-0.00.1
Intermittent access intake day 1-15 change0.40.40.50.60.7-0.40.7
Intermittent access intake escalation0.20.20.30.40.5-0.30.5
Intermittent access intake escalation 20.10.10.20.30.4-0.30.4
Intermitt. access day 1 inactive lever presses0.60.60.7-0.7-0.80.8-0.8
Intermitt. access day 15 inactive lever presses1.21.41.61.21.0-1.11.3
Intermitt. access escalation Index0.20.20.30.40.4-0.40.6
Intermittent access day 1 total infusions0.30.30.4-0.5-0.60.6-0.6
Intermittent access day 15 total infusions0.10.10.10.30.4-0.20.3
Intermittent access terminal intake (last 3 days)0.00.00.10.20.2-0.10.2
Intermittent access total infusions0.00.00.00.10.00.00.1
Intermittent access day 1 locomotion1.21.21.3-1.0-1.11.1-1.1
Intermittent access day 15 total locomotion0.10.10.20.40.4-0.30.3
Intermittent access total locomotion0.10.10.20.40.3-0.30.4
Intermittent access standard deviation1.41.41.9-1.2-1.11.4-1.0
Cocaine induced anxiety3.54.04.82.01.8-2.22.0
Post-drug Anxiety1.21.41.61.11.3-1.21.1
Baseline Anxiety0.30.30.5-0.5-0.20.7-0.6
Lifetime Intake0.00.00.00.10.0-0.00.1
Incentive Sensitization - Responses0.00.00.00.00.20.0-0.0
Incentive Sensitization - Breakpoint0.00.00.0-0.00.10.1-0.1
Progressive ratio test 1 active lever presses0.00.00.0-0.0-0.10.2-0.0
Progressive ratio test 1 breakpoint0.20.20.3-0.4-0.50.6-0.4
Progressive ratio test 1 inactive lever presses2.42.62.91.71.5-1.71.5
Progressive ratio test 2 active lever presses0.00.00.0-0.0-0.00.1-0.0
Progressive ratio test 2 breakpoint0.00.00.00.10.10.00.1
Progressive ratio test 2 inactive lever presses0.50.60.70.80.7-0.70.7
Total sessions with >9 infusions0.00.00.0-0.2-0.10.2-0.2
Short access day 1 total inactive lever presses3.03.33.91.91.6-2.01.8
Short access day 10 total inactive lever presses0.10.10.3-0.3-0.50.2-0.3
Short access day 1 total infusions0.40.50.6-0.6-0.60.7-0.7
Short access day 10 total infusions0.50.50.6-0.7-0.80.8-0.7
Short access total infusions0.50.60.6-0.7-0.80.8-0.7
Short access day 1 locomotion1.81.92.0-1.3-1.41.3-1.4
Short access day 10 total locomotion0.80.91.1-0.9-0.91.0-0.9
Short access total locomotion4.14.24.5-2.0-2.02.1-2.0
Compulsive drug intake2.52.43.1-1.6-1.81.4-1.5
One hour access (0.3 mA shock)0.00.00.1-0.2-0.30.2-0.2
One hour access (shock baseline)0.40.50.60.70.8-0.60.7
Number of responses in last shaping day0.10.10.2-0.1-0.4-0.0-0.1
Context. condit. distance diff. score3.74.55.2-2.2-2.32.2-1.8
Locomotion velocity, session 10.00.00.0-0.10.10.1-0.2
Locomotion distance, session 10.50.60.9-0.7-0.90.5-1.0
Locomotion velocity, session 20.10.10.20.10.40.00.2
Locomotion distance, session 20.81.21.3-1.1-1.11.0-1.1
Locomotion velocity, session 31.92.32.4-1.6-1.61.4-1.5
Locomotion distance, session 30.50.50.70.60.6-0.80.8
Stereotopy head waving bouts, day 30.70.81.1-0.9-1.10.9-0.8
Stereotopy head waving duration, day 32.12.62.7-1.6-1.61.7-1.6
Locomotion velocity, session 70.30.30.40.50.6-0.50.6
Locomotion distance, session 70.10.10.2-0.4-0.30.4-0.2
Stereotopy head waving bouts, day 70.80.91.1-0.9-0.81.1-1.0
Stereotopy head waving duration, day 70.10.10.1-0.2-0.20.3-0.4
Locomotion velocity, session 81.01.21.5-1.2-1.11.2-0.9
Locomotion distance, session 87.210.711.7-3.3-3.43.4-3.0
Degree of sensitization distance2.62.73.2-1.7-1.51.8-1.6
Degree of sensitization stereotypy0.00.00.00.10.10.1-0.0
Condit. Reinf. active minus inactive responses1.41.52.21.21.1-1.11.5
Condit. Reinf. active-inactive response ratio0.10.10.30.10.20.00.5
Condit. Reinf. active responses0.70.91.20.90.8-1.01.1
Condit. Reinf. inactive responses0.40.40.70.60.5-0.80.6
Incentive salience index mean1.92.23.01.51.3-1.51.7
Condit. Reinf. lever presses0.50.70.90.90.7-1.00.8
Time in familiar zone, hab. session 10.10.10.2-0.3-0.50.2-0.1
Time in novel zone, hab. session 10.20.20.50.50.7-0.40.3
Total zone transitions, hab. session 10.00.00.10.10.3-0.2-0.0
Total locomotion distance, hab. session 10.10.20.30.40.5-0.50.1
Locomotion velocity, hab. session 10.00.00.10.10.3-0.2-0.1
Time in familiar zone, hab. session 22.02.12.9-1.4-1.71.4-1.2
Time in novel zone, hab. session 22.93.04.01.62.0-1.71.5
Total zone transitions, hab. session 21.01.31.71.11.1-1.30.9
Total locomotion distance, hab. session 21.31.72.01.31.3-1.41.1
Locomotion velocity, hab. session 21.52.12.51.51.4-1.61.2
Novel to familiar place preference ratio0.50.51.20.71.1-0.50.4
Novelty place preference0.60.61.40.71.2-0.50.4
Time in novel zone, NPP test0.60.61.40.71.2-0.50.4
Total zone transitions, NPP test0.20.30.6-0.5-0.80.3-0.6
Total locomotion distance, NPP test0.00.00.1-0.1-0.2-0.1-0.3
Locomotion velocity, NPP test0.00.00.10.1-0.0-0.3-0.1
Pavlov. Cond. lever latency0.40.50.60.70.7-0.60.7
Pavlov. Cond. magazine entry latency1.62.12.4-1.5-1.51.4-1.4
Pavlov. Cond. change in total contacts1.61.72.01.31.2-1.41.4
Pavlov. Cond. index score1.62.12.4-1.5-1.51.3-1.4
Pavlov. Cond. latency score1.41.72.0-1.4-1.41.2-1.3
Pavlov. Cond. lever contacts0.50.50.8-0.7-0.90.6-0.7
Pavlov. Cond. magazine entry number1.62.02.21.51.5-1.41.2
Pavlov. Cond. intertrial magazine entries0.20.20.50.60.2-0.70.3
Pavlov. Cond. lever-magazine prob. diff.1.92.42.8-1.6-1.71.5-1.5
Pavlov. Cond. response bias0.50.60.8-0.8-0.90.7-0.6
Bone: apparent density0.00.00.0-0.2-0.10.1-0.2
Bone surface0.30.50.90.60.9-0.70.6
Bone volume0.30.50.70.60.9-0.70.6
Bone: connectivity density0.10.20.2-0.5-0.30.4-0.4
Bone: cortical apparent density0.70.90.91.00.8-1.00.9
Bone: cortical area3.04.65.12.22.2-2.31.9
Bone: cortical porosity0.00.00.00.20.2-0.20.1
Bone: cortical porosity0.10.20.2-0.4-0.40.4-0.4
Bone: cortical thickness2.03.44.11.81.9-2.01.6
Bone: cortical thickness0.40.50.7-0.7-0.60.6-0.8
Bone: cortical tissue density0.70.91.01.00.9-1.01.0
Bone: elastic displacement0.70.80.9-0.9-0.90.9-0.8
Bone: elastic work0.00.00.10.1-0.2-0.20.2
Bone: endosteal estimation0.00.00.10.30.1-0.20.3
Bone: endosteal perimeter0.50.91.21.10.9-1.00.8
Bone: final force0.40.70.90.80.7-0.90.9
Bone: final moment0.61.01.21.00.9-1.01.1
Bone: marrow area0.00.00.00.20.0-0.00.2
Bone: maximum diameter4.99.09.83.03.1-3.02.8
Bone: maximum force0.30.50.60.70.7-0.80.7
Bone: maximum moment0.50.80.90.90.8-1.00.9
Bone: minimum diameter0.00.00.0-0.0-0.0-0.0-0.2
Bone: periosteal estimation0.81.71.81.41.3-1.41.2
Bone: periosteal perimeter1.62.73.11.71.7-1.81.4
Bone: post-yield work0.20.30.40.50.7-0.50.3
Bone: stiffness0.00.00.0-0.1-0.10.1-0.2
Bone: tissue strength0.00.00.0-0.0-0.00.20.1
Bone: trabecular number0.00.00.0-0.2-0.10.2-0.1
Bone: trabecular spacing0.91.21.31.11.1-1.11.0
Bone: trabecular thickness0.91.11.3-1.1-1.20.9-1.1
Bone: trabecular tissue density0.20.30.5-0.6-0.40.7-0.6
Breakpoint value in progressive ratio session1.21.31.41.21.1-1.21.1
Distance traveled before self-admin0.20.20.30.40.4-0.50.4
Distance traveled after self-admin0.20.20.30.50.3-0.50.5
Delta time in closed arm before/after self-admin7.37.17.6-2.7-2.62.6-2.8
Delta time in open arm before/after self-admin8.27.98.12.82.8-2.82.8
Diff in mean of infusions in LGA sessions0.30.30.6-0.5-0.80.5-0.5
Extinction: sum of active levers before priming0.60.60.60.80.7-0.70.8
Active lever presses in extinction session 60.00.00.10.20.1-0.20.1
Delta distance traveled before/after self-admin0.20.20.3-0.4-0.50.4-0.5
Delta ambulatory time before/after self-admin0.40.40.5-0.6-0.60.7-0.6
Time in closed arm before self-admin0.30.40.50.60.6-0.60.7
Time in closed arm after self-admin2.22.32.5-1.5-1.51.6-1.5
Time in open arm before self-admin2.72.93.1-1.7-1.61.8-1.7
Time in open arm after self-admin0.10.20.20.40.3-0.40.4
Sum of active levers in priming session hrs 5-61.11.11.21.10.9-1.11.1
Time to tail flick, vehicle, before self-admin0.00.00.0-0.1-0.10.0-0.1
Time to tail flick, vehicle, after self-admin0.10.10.20.2-0.1-0.50.4
Time to tail flick, test, before self-admin0.80.81.0-0.9-0.91.0-0.8
Time to tail flick, test, after self-admin3.43.54.21.91.7-2.01.7
Delta time to tail flick, vehicle, before/after SA0.00.00.0-0.0-0.2-0.1-0.0
Delta time to tail flick, test, before/after SA2.92.63.21.61.5-1.81.5
Ambulatory time before self-admin0.50.50.70.70.7-0.90.7
Ambulatory time after self-admin0.20.30.30.50.5-0.60.5
Total heroin consumption0.10.10.20.20.1-0.10.4
Area under the delay curve3.43.74.22.01.9-2.01.8
Delay disc. indifference point, 0s delay0.80.81.10.90.9-1.00.7
Delay disc. indifference point, 16s delay2.92.93.11.71.6-1.81.7
Delay disc. indifference point, 2s delay1.11.21.61.10.9-1.31.0
Delay disc. indifference point, 24s delay1.81.82.01.31.2-1.31.4
Delay disc. indifference point, 4s delay3.03.13.41.91.6-1.81.7
Delay disc. indifference point, 8s delay1.21.21.51.11.1-1.20.9
Delay discount exponential model param3.13.33.8-1.9-1.81.9-1.7
Delay discount hyperbolic model param3.33.53.9-1.9-1.82.0-1.8
Fecal boli incidents, locomotor time 10.20.20.3-0.5-0.30.6-0.5
Change in fecal boli incidents, locomotor task0.00.00.10.20.2-0.10.3
Time >=10cm from walls, locomotor time 10.20.20.6-0.40.10.4-0.8
Bouts of movement, locomotor time 10.40.50.80.70.9-0.30.7
Total resting periods, locomotor time 10.20.20.30.40.6-0.00.4
Rest time, locomotor task time 10.10.10.30.10.50.1-0.1
Distance moved, locomotor task time 10.20.30.40.50.1-0.60.6
Vertical activity count, locomotor time 10.10.10.10.2-0.1-0.40.3
Time >=10cm from walls, locomotor time 20.70.81.6-0.8-0.50.8-1.2
Bouts of movement, locomotor time 20.10.10.20.3-0.3-0.30.4
Total resting periods, locomotor time 20.20.20.30.4-0.2-0.40.6
Rest time, locomotor task time 20.00.00.1-0.10.10.20.0
Distance moved, locomotor task time 20.10.10.3-0.4-0.30.2-0.6
Vertical activity count, locomotor time 20.20.20.6-0.5-0.10.2-0.8
Weight adjusted by age0.40.40.60.60.7-0.80.4
Seeking ratio, delayed vs. immediate footshock0.40.50.7-0.5-0.80.7-0.7
Locomotion in novel chamber5.16.37.2-2.6-2.42.4-2.7
Locomotion in novel chamber post-restriction3.13.73.9-1.9-1.91.9-2.0
Progressive ratio0.20.20.4-0.5-0.60.3-0.5
Food seeking constrained by brief footshock1.92.33.71.51.4-1.91.1
Seeking ratio, punishment vs. effort1.41.71.91.31.4-1.41.1
Run reversals in cocaine runway, females0.40.40.4-0.6-0.70.5-0.6
Run reversals in cocaine runway, males0.30.30.50.60.7-0.40.4
Latency to leave start box in cocaine runway0.10.10.20.3-0.2-0.30.4
Latency to leave start box in cocaine runway, F0.50.60.90.80.5-0.90.7
Latency to leave start box in cocaine runway, M0.70.71.0-0.8-1.01.0-0.5
Cd content in liver0.30.30.6-0.5-0.70.6-0.4
Co content in liver0.10.10.40.20.1-0.20.6
Cu content in liver0.50.60.70.80.8-0.80.8
Fe content in liver0.20.20.2-0.5-0.40.4-0.5
K content in liver0.50.50.90.70.7-1.00.3
Mg content in liver0.50.50.60.70.8-0.80.6
Mn content in liver0.10.10.30.40.3-0.50.2
Na content in liver4.24.55.22.12.3-2.12.0
Rb content in liver2.83.63.71.91.9-1.91.8
Se content in liver1.92.32.61.51.5-1.61.4
Sr content in liver1.81.71.81.31.1-1.41.4
Zn content in liver0.30.40.60.60.5-0.80.5