Hub : Genes

Ubap1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000012004 0.19 0.09 0.0e+00 0.18 0.18 0.18 0.18 1.5e-19 4.1e-19 3.5e-19 3.2e-19
2 Adipose mRNA stability ENSRNOG00000012004 0.06 0.04 2.0e-04 0.02 0.03 0.02 0.03 1.4e-03 4.8e-04 8.7e-04 3.9e-04
3 Liver gene expression ENSRNOG00000012004 0.15 0.08 1.6e-15 0.14 0.13 0.13 0.14 8.4e-15 3.0e-14 2.9e-14 7.0e-15
4 PL gene expression ENSRNOG00000012004 0.06 0.04 9.5e-04 0.03 0.03 0.03 0.03 2.2e-03 1.6e-03 2.8e-03 1.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
BMI with tail1.96.17.2-2.42.4-2.72.3
BMI without tail4.39.111.0-2.73.2-2.83.3
Body weight2.811.613.4-3.13.5-3.33.7
Epididymis fat weight0.51.11.6-0.71.1-1.01.3
Glucose0.60.91.5-0.61.1-0.71.2
Heart weight0.40.60.9-0.40.9-0.81.0
Left kidney weight0.41.22.0-0.41.4-0.91.4
Right kidney weight0.00.10.20.20.4-0.30.5
Tail length2.06.18.1-2.32.6-2.02.8
Length with tail0.62.23.8-1.21.6-1.11.9
Length without tail0.40.80.90.9-0.90.9-0.7
Liver weight, left0.61.01.5-0.61.2-1.01.0
Liver weight, right0.00.00.1-0.00.00.30.0
Parametrial fat weight0.10.10.20.10.4-0.10.5
Retroperitoneal fat weight0.10.20.40.5-0.60.1-0.6
Intraocular pressure2.02.83.5-1.61.9-1.31.8
Extensor digitorum longus weight5.421.723.2-4.64.7-4.54.8
Soleus weight0.20.51.30.7-0.31.10.1
Tibialis anterior weight7.726.630.2-5.15.4-4.65.5
Tibia length0.10.10.30.40.20.30.6
Number of licking bursts6.78.08.3-2.82.9-2.92.7
Food consumed during 24 hour testing period0.91.11.7-0.81.2-0.91.3
Times rat made contact with spout0.91.01.5-1.20.9-1.10.8
Mean time between licks in bursts0.30.40.50.2-0.70.7-0.7
Mean num. licks in bursts2.73.33.81.6-1.91.8-1.9
Std. dev. time between licks in bursts0.30.40.50.7-0.60.4-0.7
Water consumed over 24 hours1.51.81.9-1.31.4-1.31.3
Indifference point 0 sec0.20.40.90.50.40.50.9
Indifference point AUC5.26.18.0-2.02.7-2.22.8
Indifference point function ln k1.72.53.31.2-1.81.5-1.7
Indifference point function log k1.72.53.31.2-1.81.5-1.7
Delay discounting total patch changes 0 sec0.40.61.70.10.8-0.01.3
Delay discounting total patch changes 12 sec1.31.72.4-0.81.5-1.21.6
Delay discounting total patch changes 18 sec0.20.30.9-0.20.6-0.10.9
Delay discounting total patch changes 24 sec1.41.83.1-0.81.5-1.11.8
Delay discounting total patch changes 6 sec1.42.24.5-0.81.7-0.82.1
Delay discounting time to switch 0 sec1.62.54.01.4-1.71.1-2.0
Delay discounting water rate 0 sec0.81.32.6-0.61.3-0.61.6
Delay discounting water rate 12 sec0.00.10.1-0.40.00.00.3
Delay discounting water rate 18 sec0.50.61.2-0.80.7-1.10.5
Delay discounting water rate 24 sec0.10.10.3-0.6-0.2-0.4-0.2
Delay discounting water rate 6 sec1.42.12.4-1.61.4-1.41.4
Locomotor activity0.00.00.10.00.2-0.20.2
Locomotor testing distance0.00.10.10.30.00.30.3
Locomotor testing rearing1.21.82.7-1.31.4-1.01.6
Light reinforcement 11.12.03.6-0.21.8-1.01.9
Light reinforcement 20.40.61.00.61.0-0.01.0
Reaction time number correct0.00.00.10.20.10.30.2
Reaction time mean minus median0.91.22.5-1.30.6-1.60.1
Reaction time mean minus median AUC1.62.14.1-1.61.1-2.00.7
Reaction time num false alarms0.20.20.5-0.70.2-0.70.1
Reaction time num false alarms AUC0.60.81.2-1.00.8-1.10.7
Reaction time trials correct on left0.00.00.10.20.10.30.2
Reaction time trials on left0.00.10.10.30.00.40.1
Reaction time mean0.81.12.60.0-1.20.4-1.6
Reaction time mean AUC0.91.22.9-0.1-1.30.5-1.7
Median of all reaction times1.92.64.40.7-1.91.4-2.1
Reaction time omissions1.01.32.20.5-1.40.8-1.5
Reaction time false alarm rate0.10.20.4-0.50.1-0.60.0
Reaction time premature initiation rate2.22.94.01.4-2.01.4-2.0
Reaction time premature initiations1.72.43.01.3-1.71.4-1.7
Std. dev. reaction times0.30.40.6-0.7-0.3-0.7-0.8
Reaction time trials completed0.00.10.10.30.00.40.1
Reaction time trials AUC0.00.10.10.30.00.40.0
Social response proportion2.93.14.12.0-1.61.6-1.8
Social responses0.40.50.7-0.50.9-0.70.8
Social time0.10.10.20.2-0.20.5-0.2
Conditioned locomotion0.10.10.20.2-0.00.50.1
Cocaine response after cond. corrected1.71.92.61.6-1.21.6-1.0
Cocaine response after cond. not corrected1.41.52.31.5-1.11.5-0.7
Cocaine response before conditioning1.11.31.8-1.41.0-1.01.1
Saline control response1.31.72.5-1.11.4-1.11.6
Condit. Reinf. active minus inactive responses0.50.60.7-0.70.9-0.80.8
Condit. Reinf. active-inactive response ratio0.00.00.00.00.1-0.10.0
Condit. Reinf. active responses2.02.83.3-1.61.7-1.51.8
Condit. Reinf. inactive responses3.64.54.6-2.12.1-2.12.1
Condit. Reinf. lever presses2.63.65.0-2.21.6-2.01.7
Condit. Reinf. lever reinforcers received2.53.53.9-1.91.9-1.72.0
Pavlov. Cond. lever latency3.95.310.23.2-1.82.1-1.9
Pavlov. Cond. magazine entry latency0.20.30.4-0.7-0.60.4-0.5
Pavlov. Cond. change in total contacts1.31.84.9-2.20.7-1.20.7
Pavlov. Cond. index score0.81.03.6-1.90.3-0.60.4
Pavlov. Cond. latency score1.11.44.3-2.10.4-0.80.5
Pavlov. Cond. lever contacts2.02.75.9-2.41.2-1.41.3
Pavlov. Cond. magazine entry number0.60.72.61.6-0.00.4-0.1
Pavlov. Cond. intertrial magazine entries0.30.40.50.50.7-0.50.6
Pavlov. Cond. lever-magazine prob. diff.0.81.03.5-1.90.2-0.60.3
Pavlov. Cond. response bias1.11.54.1-2.00.7-0.90.8
Conditioned reinforcement - actives1.11.11.3-1.11.0-1.11.0
Conditioned reinforcement - inactives0.70.80.8-0.90.9-0.90.9
Conditioned locomotion0.50.70.8-0.70.8-0.80.9
Intermittent access intake day 1-15 change1.01.01.4-1.20.8-1.20.7
Intermittent access intake escalation1.01.01.2-1.00.9-1.10.9
Intermittent access intake escalation 22.12.12.7-1.61.3-1.71.1
Intermitt. access day 1 inactive lever presses0.40.40.7-0.50.8-0.40.8
Intermitt. access day 15 inactive lever presses0.10.10.3-0.10.4-0.20.5
Intermitt. access escalation Index0.80.71.1-0.71.0-0.71.0
Intermittent access day 1 total infusions0.60.71.01.0-0.71.0-0.6
Intermittent access day 15 total infusions0.40.40.5-0.60.7-0.60.7
Intermittent access terminal intake (last 3 days)1.51.61.8-1.21.4-1.21.3
Intermittent access total infusions0.70.81.1-0.71.0-0.81.0
Intermittent access day 1 locomotion2.12.22.71.6-1.31.6-1.3
Intermittent access day 15 total locomotion1.21.21.41.2-1.01.2-1.0
Intermittent access total locomotion0.50.50.70.6-0.80.6-0.9
Intermittent access standard deviation0.60.60.7-0.80.8-0.80.8
Cocaine induced anxiety0.40.50.50.7-0.70.7-0.7
Post-drug Anxiety0.50.60.8-0.70.9-0.60.9
Baseline Anxiety0.80.81.1-0.90.9-1.00.7
Lifetime Intake1.01.11.8-0.81.3-0.71.3
Incentive Sensitization - Responses0.30.30.6-0.40.8-0.30.7
Incentive Sensitization - Breakpoint0.20.20.3-0.30.6-0.20.5
Progressive ratio test 1 active lever presses0.60.71.0-0.71.0-0.60.9
Progressive ratio test 1 breakpoint0.90.91.3-0.81.1-0.61.1
Progressive ratio test 1 inactive lever presses0.80.91.6-0.51.2-0.41.2
Progressive ratio test 2 active lever presses0.20.20.4-0.10.60.00.7
Progressive ratio test 2 breakpoint0.10.10.10.00.30.20.4
Progressive ratio test 2 inactive lever presses0.70.81.2-0.81.0-0.61.1
Total sessions with >9 infusions0.20.20.5-0.00.50.20.7
Short access day 1 total inactive lever presses2.73.04.5-1.32.0-1.32.1
Short access day 10 total inactive lever presses0.40.40.6-0.50.7-0.60.8
Short access day 1 total infusions2.62.74.3-1.31.9-1.12.1
Short access day 10 total infusions0.30.30.8-0.10.70.10.9
Short access total infusions0.60.71.4-0.51.0-0.21.2
Short access day 1 locomotion0.60.61.10.8-0.61.1-0.5
Short access day 10 total locomotion0.91.01.40.9-1.10.8-1.2
Short access total locomotion0.10.10.20.3-0.10.5-0.0
Compulsive drug intake0.00.00.10.10.10.30.2
One hour access (0.3 mA shock)0.30.40.8-0.40.7-0.20.9
One hour access (shock baseline)0.20.30.6-0.20.6-0.20.7
Number of responses in last shaping day0.30.30.70.30.50.50.9
Context. condit. distance diff. score0.10.10.20.1-0.30.2-0.4
Locomotion velocity, session 10.50.50.90.60.40.80.9
Locomotion distance, session 10.20.20.40.30.40.50.6
Locomotion velocity, session 21.92.22.8-1.71.5-1.31.5
Locomotion distance, session 21.52.13.6-1.11.7-0.91.9
Locomotion velocity, session 30.10.10.20.20.10.30.4
Locomotion distance, session 31.61.72.6-1.21.5-0.91.6
Stereotopy head waving bouts, day 30.00.00.1-0.30.00.10.3
Stereotopy head waving duration, day 30.00.00.1-0.1-0.3-0.0-0.1
Locomotion velocity, session 70.00.00.1-0.2-0.30.2-0.2
Locomotion distance, session 70.10.20.3-0.40.5-0.20.6
Stereotopy head waving bouts, day 73.23.63.7-1.91.9-1.91.9
Stereotopy head waving duration, day 71.11.41.5-1.21.1-1.21.2
Locomotion velocity, session 80.10.10.20.10.20.40.4
Locomotion distance, session 80.10.20.40.00.50.10.6
Degree of sensitization distance0.70.71.00.5-1.00.7-1.0
Degree of sensitization stereotypy1.71.92.0-1.41.4-1.31.3
Condit. Reinf. active minus inactive responses0.50.60.8-0.90.7-0.60.8
Condit. Reinf. active-inactive response ratio0.60.60.80.5-0.90.8-0.9
Condit. Reinf. active responses3.13.84.9-2.21.9-1.71.9
Condit. Reinf. inactive responses3.84.46.1-2.52.0-2.02.0
Incentive salience index mean4.35.16.2-2.22.4-1.92.5
Condit. Reinf. lever presses9.713.016.9-3.33.9-3.14.1
Time in familiar zone, hab. session 10.40.40.8-0.6-0.5-0.4-0.9
Time in novel zone, hab. session 11.71.73.41.1-1.21.8-0.7
Total zone transitions, hab. session 10.10.10.10.3-0.20.4-0.2
Total locomotion distance, hab. session 10.20.30.7-0.40.5-0.80.3
Locomotion velocity, hab. session 11.01.52.2-0.81.4-1.51.1
Time in familiar zone, hab. session 20.40.51.00.2-0.80.2-1.0
Time in novel zone, hab. session 21.11.11.71.1-1.01.3-0.7
Total zone transitions, hab. session 20.20.30.80.00.7-0.00.9
Total locomotion distance, hab. session 20.50.71.0-0.51.0-0.81.0
Locomotion velocity, hab. session 20.60.81.2-0.51.1-0.81.0
Novel to familiar place preference ratio3.53.74.72.0-1.92.2-1.7
Novelty place preference4.85.05.62.4-2.22.4-2.0
Time in novel zone, NPP test5.65.96.72.4-2.42.6-2.2
Total zone transitions, NPP test0.30.40.9-0.20.9-0.21.0
Total locomotion distance, NPP test1.01.42.3-0.41.5-0.91.5
Locomotion velocity, NPP test1.31.93.0-0.41.7-1.21.7
Pavlov. Cond. lever latency8.510.812.93.3-3.32.9-3.6
Pavlov. Cond. magazine entry latency0.50.61.5-1.20.5-0.40.7
Pavlov. Cond. change in total contacts2.82.94.1-1.71.7-1.32.0
Pavlov. Cond. index score3.74.75.9-2.42.1-1.82.3
Pavlov. Cond. latency score3.54.45.6-2.42.0-1.82.2
Pavlov. Cond. lever contacts6.17.28.4-2.92.6-2.32.9
Pavlov. Cond. magazine entry number0.81.01.81.4-0.90.7-1.0
Pavlov. Cond. intertrial magazine entries0.30.30.3-0.50.6-0.60.5
Pavlov. Cond. lever-magazine prob. diff.3.44.25.8-2.41.9-1.82.1
Pavlov. Cond. response bias3.34.15.6-2.41.9-1.62.1
Bone: apparent density1.21.92.2-1.41.3-1.51.3
Bone surface0.61.01.4-1.01.0-0.81.2
Bone volume0.71.11.3-1.11.0-1.01.1
Bone: connectivity density0.50.71.0-0.90.7-1.00.7
Bone: cortical apparent density0.10.10.3-0.5-0.2-0.3-0.3
Bone: cortical area2.33.53.8-2.01.8-1.91.8
Bone: cortical porosity0.50.51.01.0-0.70.5-0.7
Bone: cortical porosity0.00.00.10.40.0-0.2-0.0
Bone: cortical thickness0.91.42.1-1.31.0-1.50.9
Bone: cortical thickness0.10.10.20.0-0.40.0-0.4
Bone: cortical tissue density0.10.10.2-0.4-0.3-0.2-0.4
Bone: elastic displacement5.46.27.62.1-2.72.2-2.8
Bone: elastic work1.52.03.90.9-1.70.8-2.0
Bone: endosteal estimation0.92.02.9-1.51.5-0.81.7
Bone: endosteal perimeter1.02.02.8-1.41.5-0.91.7
Bone: final force1.52.42.6-1.51.6-1.61.6
Bone: final moment1.21.92.2-1.41.4-1.51.3
Bone: marrow area1.02.22.9-1.71.6-0.91.7
Bone: maximum diameter2.44.45.1-2.32.1-1.92.1
Bone: maximum force3.56.16.5-2.42.5-2.52.4
Bone: maximum moment2.74.85.3-2.22.1-2.32.1
Bone: minimum diameter0.00.10.1-0.1-0.30.2-0.4
Bone: periosteal estimation1.63.33.8-2.01.8-1.51.9
Bone: periosteal perimeter0.50.81.2-0.90.9-0.51.1
Bone: post-yield work1.62.22.8-1.41.6-1.21.7
Bone: stiffness4.57.17.5-2.52.7-2.72.7
Bone: tissue strength0.20.20.3-0.40.5-0.60.4
Bone: trabecular number1.11.72.4-1.21.2-1.51.2
Bone: trabecular spacing0.00.00.1-0.20.1-0.3-0.0
Bone: trabecular thickness0.10.10.2-0.2-0.50.3-0.4
Bone: trabecular tissue density3.65.05.5-2.22.3-2.12.2
Breakpoint value in progressive ratio session0.91.01.51.2-0.81.2-0.5
Distance traveled before self-admin6.16.58.5-2.22.8-2.12.9
Distance traveled after self-admin3.13.44.2-2.01.7-2.01.6
Delta time in closed arm before/after self-admin1.41.41.8-1.40.9-1.31.0
Delta time in open arm before/after self-admin0.20.20.30.6-0.10.5-0.3
Diff in mean of infusions in LGA sessions0.00.00.10.1-0.20.1-0.3
Extinction: sum of active levers before priming1.01.01.51.0-0.90.9-1.2
Active lever presses in extinction session 62.02.02.21.5-1.31.5-1.3
Delta distance traveled before/after self-admin0.10.10.20.0-0.30.0-0.4
Delta ambulatory time before/after self-admin0.40.40.90.4-0.70.4-0.9
Time in closed arm before self-admin3.64.14.62.1-1.82.0-2.1
Time in closed arm after self-admin0.50.50.60.7-0.80.6-0.7
Time in open arm before self-admin2.32.54.0-1.41.6-1.22.0
Time in open arm after self-admin1.41.52.1-1.01.4-0.91.5
Sum of active levers in priming session hrs 5-64.74.75.52.3-2.02.3-1.9
Time to tail flick, vehicle, before self-admin2.52.52.91.6-1.71.4-1.6
Time to tail flick, vehicle, after self-admin0.00.00.0-0.0-0.10.20.0
Time to tail flick, test, before self-admin0.60.60.8-0.90.8-0.80.6
Time to tail flick, test, after self-admin0.00.00.1-0.30.1-0.30.1
Delta time to tail flick, vehicle, before/after SA0.50.50.7-0.80.8-0.50.8
Delta time to tail flick, test, before/after SA0.60.50.50.7-0.70.7-0.7
Ambulatory time before self-admin3.84.06.0-1.62.3-1.52.4
Ambulatory time after self-admin0.91.01.1-1.01.0-0.91.1
Total heroin consumption0.20.30.50.5-0.50.7-0.4
Area under the delay curve0.90.91.21.1-0.91.1-0.8
Delay disc. indifference point, 0s delay1.41.51.91.2-1.21.4-1.1
Delay disc. indifference point, 16s delay1.31.42.21.5-0.91.3-0.8
Delay disc. indifference point, 2s delay0.20.20.4-0.60.2-0.50.2
Delay disc. indifference point, 24s delay0.50.50.60.7-0.70.7-0.6
Delay disc. indifference point, 4s delay0.20.20.30.4-0.50.4-0.4
Delay disc. indifference point, 8s delay0.00.00.10.3-0.20.2-0.1
Delay discount exponential model param0.80.81.1-1.10.8-1.00.7
Delay discount hyperbolic model param0.70.71.0-1.00.8-1.00.6
Fecal boli incidents, locomotor time 11.71.82.11.4-1.51.2-1.4
Change in fecal boli incidents, locomotor task0.90.91.3-0.61.1-0.71.2
Time >=10cm from walls, locomotor time 10.00.00.10.10.2-0.00.2
Bouts of movement, locomotor time 10.91.01.40.9-1.20.6-1.2
Total resting periods, locomotor time 11.31.42.30.9-1.50.6-1.5
Rest time, locomotor task time 10.80.92.10.3-1.2-0.1-1.4
Distance moved, locomotor task time 11.71.83.2-1.01.6-0.71.8
Vertical activity count, locomotor time 10.90.91.9-0.61.2-0.31.4
Time >=10cm from walls, locomotor time 20.00.00.10.20.3-0.10.3
Bouts of movement, locomotor time 20.91.01.1-1.01.0-1.10.9
Total resting periods, locomotor time 20.50.50.7-0.80.7-0.80.6
Rest time, locomotor task time 20.30.40.70.2-0.90.0-0.8
Distance moved, locomotor task time 20.20.30.4-0.70.6-0.30.6
Vertical activity count, locomotor time 20.20.20.4-0.30.50.10.6
Weight adjusted by age0.10.10.20.4-0.00.50.3
Seeking ratio, delayed vs. immediate footshock3.23.74.1-1.92.0-1.82.0
Locomotion in novel chamber0.00.10.10.2-0.30.0-0.3
Locomotion in novel chamber post-restriction2.12.53.5-1.81.3-1.91.2
Progressive ratio0.30.40.70.7-0.40.8-0.4
Food seeking constrained by brief footshock7.59.212.6-2.53.6-2.43.5
Seeking ratio, punishment vs. effort3.54.34.7-2.02.2-2.12.1
Run reversals in cocaine runway, females0.10.10.30.3-0.2-0.2-0.5
Run reversals in cocaine runway, males0.00.00.0-0.1-0.0-0.2-0.1
Latency to leave start box in cocaine runway1.01.01.1-1.11.0-1.01.0
Latency to leave start box in cocaine runway, F0.10.10.10.4-0.20.3-0.1
Latency to leave start box in cocaine runway, M2.42.32.6-1.51.6-1.41.6
Cd content in liver1.21.41.9-1.41.1-1.20.8
Co content in liver1.01.21.41.1-1.11.2-0.9
Cu content in liver0.40.51.00.1-0.90.5-1.0
Fe content in liver0.20.20.5-0.10.30.40.7
K content in liver0.70.71.31.1-0.70.8-0.5
Mg content in liver1.31.31.61.2-1.31.1-1.1
Mn content in liver0.50.61.2-0.80.4-1.10.5
Na content in liver0.91.01.21.0-1.00.8-1.1
Rb content in liver4.55.66.32.5-2.42.3-2.3
Se content in liver2.32.83.6-1.71.6-1.91.5
Sr content in liver0.70.60.8-0.90.7-0.90.6
Zn content in liver0.20.20.5-0.7-0.1-0.4-0.1