Hub : Genes

Slc2a2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression ENSRNOG00000011875 0.1 0.05 1.8e-07 0.04 0.04 0.03 0.04 1.5e-05 4.7e-05 2.2e-04 7.1e-05
2 Liver mRNA stability ENSRNOG00000011875 0.27 0.1 0.0e+00 0.28 0.27 0.25 0.27 1.0e-30 8.4e-30 4.6e-28 5.2e-30

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
BMI with tail0.51.72.0-1.1-1.4
BMI without tail0.61.32.6-1.6-0.3
Body weight0.20.81.6-0.1-1.3
Epididymis fat weight0.20.50.80.50.9
Glucose2.94.45.51.82.3
Heart weight1.21.72.8-1.7-0.7
Left kidney weight0.00.10.2-0.50.2
Right kidney weight0.10.40.6-0.8-0.5
Tail length0.10.30.6-0.8-0.0
Length with tail0.10.20.20.5-0.5
Length without tail0.51.11.51.2-0.8
Liver weight, left1.22.03.71.90.5
Liver weight, right0.50.91.40.61.2
Parametrial fat weight0.30.61.20.11.1
Retroperitoneal fat weight0.30.91.30.71.2
Intraocular pressure0.30.40.50.50.7
Extensor digitorum longus weight0.21.01.1-0.9-1.1
Soleus weight6.819.935.0-5.9-2.2
Tibialis anterior weight0.20.81.1-1.1-0.7
Tibia length3.08.510.83.32.5
Number of licking bursts0.10.10.10.4-0.2
Food consumed during 24 hour testing period0.10.10.20.1-0.5
Times rat made contact with spout0.60.71.41.2-0.1
Mean time between licks in bursts1.01.41.61.01.3
Mean num. licks in bursts0.00.00.1-0.0-0.3
Std. dev. time between licks in bursts0.70.91.61.30.4
Water consumed over 24 hours0.10.10.10.3-0.2
Indifference point 0 sec0.10.10.2-0.50.2
Indifference point AUC0.81.01.3-1.1-0.8
Indifference point function ln k1.82.62.71.61.6
Indifference point function log k1.82.62.71.61.6
Delay discounting total patch changes 0 sec0.10.20.3-0.60.2
Delay discounting total patch changes 12 sec1.01.31.5-1.0-1.2
Delay discounting total patch changes 18 sec0.91.21.8-0.8-1.3
Delay discounting total patch changes 24 sec2.32.93.7-1.9-1.4
Delay discounting total patch changes 6 sec1.21.83.3-1.8-0.5
Delay discounting time to switch 0 sec0.00.00.10.3-0.0
Delay discounting water rate 0 sec0.30.50.7-0.50.8
Delay discounting water rate 12 sec0.61.01.90.31.4
Delay discounting water rate 18 sec0.50.71.21.1-0.4
Delay discounting water rate 24 sec0.60.81.3-1.1-0.6
Delay discounting water rate 6 sec0.20.40.6-0.30.8
Locomotor activity0.81.32.01.4-0.8
Locomotor testing distance1.11.83.00.8-1.7
Locomotor testing rearing0.20.20.40.3-0.6
Light reinforcement 10.10.20.40.20.6
Light reinforcement 20.20.30.3-0.5-0.5
Reaction time number correct1.72.43.01.41.7
Reaction time mean minus median0.40.50.90.2-1.0
Reaction time mean minus median AUC0.30.40.8-0.1-0.9
Reaction time num false alarms1.11.52.9-0.3-1.7
Reaction time num false alarms AUC0.40.51.0-0.0-1.0
Reaction time trials correct on left1.72.43.01.41.7
Reaction time trials on left1.82.53.01.41.7
Reaction time mean0.71.01.41.2-0.7
Reaction time mean AUC0.60.91.11.0-0.8
Median of all reaction times0.50.71.11.1-0.5
Reaction time omissions0.30.40.60.8-0.5
Reaction time false alarm rate1.42.03.3-0.9-1.8
Reaction time premature initiation rate1.01.42.6-0.41.6
Reaction time premature initiations2.33.36.20.62.5
Std. dev. reaction times1.01.32.50.4-1.6
Reaction time trials completed1.82.53.01.41.7
Reaction time trials AUC1.82.53.01.41.7
Social response proportion1.92.02.71.61.2
Social responses0.20.30.6-0.70.2
Social time1.82.34.02.00.8
Conditioned locomotion0.30.40.4-0.60.6
Cocaine response after cond. corrected0.00.00.10.3-0.1
Cocaine response after cond. not corrected0.40.50.91.00.1
Cocaine response before conditioning0.10.10.10.3-0.3
Saline control response0.40.50.50.70.7
Condit. Reinf. active minus inactive responses1.01.31.70.9-1.3
Condit. Reinf. active-inactive response ratio0.50.50.70.6-0.8
Condit. Reinf. active responses1.42.03.71.9-0.5
Condit. Reinf. inactive responses1.72.13.71.90.6
Condit. Reinf. lever presses0.81.11.60.7-1.3
Condit. Reinf. lever reinforcers received1.31.93.41.8-0.6
Pavlov. Cond. lever latency0.60.81.60.01.2
Pavlov. Cond. magazine entry latency0.20.20.40.60.1
Pavlov. Cond. change in total contacts2.02.84.21.2-2.1
Pavlov. Cond. index score0.60.81.40.4-1.2
Pavlov. Cond. latency score0.40.50.80.5-0.9
Pavlov. Cond. lever contacts0.60.81.4-0.3-1.2
Pavlov. Cond. magazine entry number0.50.71.3-0.11.1
Pavlov. Cond. intertrial magazine entries0.10.10.10.20.4
Pavlov. Cond. lever-magazine prob. diff.0.50.61.00.5-1.0
Pavlov. Cond. response bias0.91.22.4-0.1-1.5
Conditioned reinforcement - actives0.30.30.70.8-0.0
Conditioned reinforcement - inactives0.50.51.1-0.1-1.0
Conditioned locomotion0.50.70.80.9-0.7
Intermittent access intake day 1-15 change0.00.00.00.1-0.2
Intermittent access intake escalation0.10.10.20.1-0.4
Intermittent access intake escalation 20.10.10.20.50.1
Intermitt. access day 1 inactive lever presses0.60.61.10.41.0
Intermitt. access day 15 inactive lever presses1.92.12.51.61.3
Intermitt. access escalation Index0.10.10.3-0.1-0.5
Intermittent access day 1 total infusions2.93.35.62.40.9
Intermittent access day 15 total infusions0.80.91.71.3-0.0
Intermittent access terminal intake (last 3 days)2.52.74.92.20.7
Intermittent access total infusions1.92.13.92.00.6
Intermittent access day 1 locomotion0.60.61.31.10.0
Intermittent access day 15 total locomotion0.60.60.7-0.8-0.8
Intermittent access total locomotion0.20.20.40.60.1
Intermittent access standard deviation0.20.20.40.3-0.6
Cocaine induced anxiety0.10.20.3-0.1-0.6
Post-drug Anxiety0.50.61.01.00.4
Baseline Anxiety0.60.60.60.80.8
Lifetime Intake2.52.85.12.30.6
Incentive Sensitization - Responses0.50.50.50.6-0.7
Incentive Sensitization - Breakpoint0.50.50.60.8-0.6
Progressive ratio test 1 active lever presses0.50.50.91.00.4
Progressive ratio test 1 breakpoint0.70.71.41.20.2
Progressive ratio test 1 inactive lever presses0.50.61.01.00.4
Progressive ratio test 2 active lever presses0.60.71.31.1-0.3
Progressive ratio test 2 breakpoint0.40.50.90.9-0.3
Progressive ratio test 2 inactive lever presses1.01.12.11.40.4
Total sessions with >9 infusions0.80.81.51.20.4
Short access day 1 total inactive lever presses0.30.40.50.5-0.7
Short access day 10 total inactive lever presses1.01.12.1-1.40.3
Short access day 1 total infusions0.90.91.91.40.1
Short access day 10 total infusions1.31.42.41.50.7
Short access total infusions2.52.85.32.30.6
Short access day 1 locomotion1.61.72.6-0.8-1.6
Short access day 10 total locomotion1.31.42.3-0.7-1.5
Short access total locomotion0.20.20.20.4-0.4
Compulsive drug intake0.20.20.30.6-0.3
One hour access (0.3 mA shock)1.21.42.81.7-0.1
One hour access (shock baseline)1.21.42.21.50.7
Number of responses in last shaping day0.00.00.10.1-0.3
Context. condit. distance diff. score2.12.64.6-2.2-0.7
Locomotion velocity, session 10.80.81.71.30.1
Locomotion distance, session 10.30.40.80.9-0.3
Locomotion velocity, session 21.61.92.51.61.1
Locomotion distance, session 20.40.61.11.10.2
Locomotion velocity, session 30.00.00.00.1-0.1
Locomotion distance, session 30.20.20.20.5-0.5
Stereotopy head waving bouts, day 30.00.00.0-0.00.1
Stereotopy head waving duration, day 31.01.31.8-1.3-0.8
Locomotion velocity, session 70.20.20.30.5-0.4
Locomotion distance, session 70.20.20.30.50.3
Stereotopy head waving bouts, day 72.52.84.6-1.0-2.2
Stereotopy head waving duration, day 72.22.74.0-1.2-2.0
Locomotion velocity, session 80.30.40.8-0.90.2
Locomotion distance, session 80.30.40.8-0.9-0.3
Degree of sensitization distance0.50.50.50.70.7
Degree of sensitization stereotypy2.83.14.7-1.2-2.2
Condit. Reinf. active minus inactive responses1.61.83.61.90.3
Condit. Reinf. active-inactive response ratio1.21.32.51.60.1
Condit. Reinf. active responses1.11.32.41.60.4
Condit. Reinf. inactive responses0.00.00.0-0.00.1
Incentive salience index mean1.82.23.61.90.9
Condit. Reinf. lever presses0.71.01.01.01.0
Time in familiar zone, hab. session 10.20.20.3-0.3-0.5
Time in novel zone, hab. session 11.91.82.8-1.7-0.9
Total zone transitions, hab. session 11.31.93.3-0.7-1.8
Total locomotion distance, hab. session 11.82.53.3-1.8-1.3
Locomotion velocity, hab. session 11.42.02.2-1.5-1.3
Time in familiar zone, hab. session 20.70.81.50.01.2
Time in novel zone, hab. session 24.64.78.1-1.1-2.8
Total zone transitions, hab. session 20.10.10.30.50.0
Total locomotion distance, hab. session 20.20.30.4-0.4-0.6
Locomotion velocity, hab. session 20.00.00.0-0.2-0.1
Novel to familiar place preference ratio8.28.611.0-3.3-2.5
Novelty place preference10.310.713.9-3.7-2.7
Time in novel zone, NPP test11.512.115.6-3.9-2.9
Total zone transitions, NPP test0.91.32.11.50.6
Total locomotion distance, NPP test0.40.50.70.90.5
Locomotion velocity, NPP test0.60.81.21.10.6
Pavlov. Cond. lever latency1.82.33.1-1.8-1.2
Pavlov. Cond. magazine entry latency0.30.40.50.5-0.7
Pavlov. Cond. change in total contacts2.22.33.41.11.8
Pavlov. Cond. index score0.81.01.61.30.5
Pavlov. Cond. latency score1.31.72.61.60.9
Pavlov. Cond. lever contacts2.42.82.91.61.7
Pavlov. Cond. magazine entry number0.10.20.2-0.50.3
Pavlov. Cond. intertrial magazine entries1.11.31.71.31.0
Pavlov. Cond. lever-magazine prob. diff.0.60.81.21.10.7
Pavlov. Cond. response bias0.10.10.20.5-0.1
Bone: apparent density1.42.44.7-2.2-0.2
Bone surface0.00.00.0-0.20.0
Bone volume0.10.20.3-0.40.5
Bone: connectivity density1.21.82.6-1.6-1.0
Bone: cortical apparent density0.70.91.6-0.41.3
Bone: cortical area0.40.71.2-0.31.1
Bone: cortical porosity0.40.40.7-0.4-0.8
Bone: cortical porosity0.20.20.3-0.5-0.3
Bone: cortical thickness0.50.81.0-0.81.0
Bone: cortical thickness0.10.20.3-0.10.6
Bone: cortical tissue density0.70.91.7-0.51.3
Bone: elastic displacement0.00.00.1-0.1-0.2
Bone: elastic work0.40.50.60.60.8
Bone: endosteal estimation0.61.32.01.40.8
Bone: endosteal perimeter0.71.51.61.31.1
Bone: final force0.10.10.20.30.5
Bone: final moment0.00.00.1-0.00.3
Bone: marrow area0.51.01.61.30.7
Bone: maximum diameter0.40.71.30.01.2
Bone: maximum force0.50.91.40.71.2
Bone: maximum moment0.30.60.90.51.0
Bone: minimum diameter0.81.51.71.31.2
Bone: periosteal estimation0.40.91.10.81.1
Bone: periosteal perimeter0.40.61.20.31.1
Bone: post-yield work0.70.91.81.30.2
Bone: stiffness0.71.12.00.51.4
Bone: tissue strength0.20.20.30.3-0.6
Bone: trabecular number3.14.88.4-2.9-1.1
Bone: trabecular spacing3.03.87.52.70.3
Bone: trabecular thickness0.91.11.4-0.91.2
Bone: trabecular tissue density2.63.66.31.02.5
Breakpoint value in progressive ratio session3.43.85.1-1.6-2.3
Distance traveled before self-admin1.21.31.9-0.8-1.4
Distance traveled after self-admin0.91.01.2-0.9-1.1
Delta time in closed arm before/after self-admin2.22.22.3-1.5-1.4
Delta time in open arm before/after self-admin1.41.32.61.60.1
Diff in mean of infusions in LGA sessions2.12.42.6-1.6-1.5
Extinction: sum of active levers before priming0.50.50.9-0.3-0.9
Active lever presses in extinction session 62.12.03.9-0.4-2.0
Delta distance traveled before/after self-admin0.00.00.0-0.10.2
Delta ambulatory time before/after self-admin0.10.10.1-0.20.4
Time in closed arm before self-admin0.70.81.40.51.2
Time in closed arm after self-admin0.50.50.9-0.31.0
Time in open arm before self-admin3.73.94.0-1.9-2.0
Time in open arm after self-admin1.21.32.5-0.4-1.6
Sum of active levers in priming session hrs 5-61.31.32.50.2-1.6
Time to tail flick, vehicle, before self-admin0.90.91.00.91.0
Time to tail flick, vehicle, after self-admin1.31.42.31.5-0.7
Time to tail flick, test, before self-admin3.23.15.7-2.4-0.8
Time to tail flick, test, after self-admin3.23.25.6-2.4-0.9
Delta time to tail flick, vehicle, before/after SA0.90.91.51.2-0.5
Delta time to tail flick, test, before/after SA0.20.20.3-0.4-0.5
Ambulatory time before self-admin0.40.40.5-0.5-0.7
Ambulatory time after self-admin0.50.60.8-0.6-0.9
Total heroin consumption3.03.63.8-1.9-1.9
Area under the delay curve0.70.81.1-1.1-0.6
Delay disc. indifference point, 0s delay0.20.30.50.70.1
Delay disc. indifference point, 16s delay1.71.73.4-1.8-0.3
Delay disc. indifference point, 2s delay0.10.10.1-0.4-0.1
Delay disc. indifference point, 24s delay1.01.01.8-1.3-0.4
Delay disc. indifference point, 4s delay0.30.30.5-0.7-0.2
Delay disc. indifference point, 8s delay0.10.10.1-0.3-0.2
Delay discount exponential model param0.80.91.41.20.6
Delay discount hyperbolic model param0.60.61.01.00.5
Fecal boli incidents, locomotor time 10.80.81.21.10.6
Change in fecal boli incidents, locomotor task1.91.81.9-1.3-1.4
Time >=10cm from walls, locomotor time 10.50.50.9-0.4-1.0
Bouts of movement, locomotor time 11.51.72.90.71.7
Total resting periods, locomotor time 11.41.62.30.91.5
Rest time, locomotor task time 10.20.30.40.70.3
Distance moved, locomotor task time 10.91.01.1-1.1-0.9
Vertical activity count, locomotor time 11.51.51.7-1.3-1.2
Time >=10cm from walls, locomotor time 21.41.52.80.5-1.7
Bouts of movement, locomotor time 20.30.40.7-0.20.8
Total resting periods, locomotor time 20.40.50.8-0.20.9
Rest time, locomotor task time 20.60.70.8-0.80.9
Distance moved, locomotor task time 20.30.40.40.6-0.7
Vertical activity count, locomotor time 20.20.30.40.6-0.4
Weight adjusted by age2.42.72.91.61.7
Seeking ratio, delayed vs. immediate footshock1.41.62.0-1.1-1.4
Locomotion in novel chamber0.00.10.10.3-0.0
Locomotion in novel chamber post-restriction0.60.71.50.11.2
Progressive ratio0.40.40.8-0.3-0.9
Food seeking constrained by brief footshock0.50.61.1-0.4-1.1
Seeking ratio, punishment vs. effort0.00.00.0-0.2-0.0
Run reversals in cocaine runway, females0.80.80.9-0.90.8
Run reversals in cocaine runway, males0.40.40.60.80.3
Latency to leave start box in cocaine runway0.20.20.4-0.3-0.6
Latency to leave start box in cocaine runway, F0.00.00.0-0.1-0.2
Latency to leave start box in cocaine runway, M0.60.50.7-0.6-0.8
Cd content in liver1.92.12.71.21.7
Co content in liver0.50.60.90.9-0.5
Cu content in liver1.21.52.31.5-0.8
Fe content in liver0.10.20.30.6-0.1
K content in liver0.10.10.1-0.40.2
Mg content in liver0.10.10.2-0.2-0.4
Mn content in liver0.10.10.2-0.50.2
Na content in liver0.60.61.2-1.1-0.0
Rb content in liver1.82.34.1-0.7-2.0
Se content in liver1.21.41.91.41.0
Sr content in liver0.40.30.5-0.4-0.7
Zn content in liver0.40.40.80.90.2