Hub : Genes

Poglut2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000011740 0.04 0.03 1.5e-04 0.01 0.01 0.01 0.01 6.2e-02 1.2e-02 1.7e-02 4.4e-02
2 Liver gene expression ENSRNOG00000011740 0.03 0.03 2.7e-03 0.01 0.01 0 0.01 8.3e-03 3.9e-02 2.9e-01 3.4e-02
3 PL gene expression ENSRNOG00000011740 0.04 0.03 7.0e-04 0.04 0.04 0.03 0.04 3.6e-04 6.7e-04 1.7e-03 4.7e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail3.110.011.33.03.4-3.2
BMI without tail0.00.00.1-0.2-0.20.2
Body weight0.10.50.70.80.6-0.8
Epididymis fat weight0.00.00.0-0.1-0.10.0
Glucose0.00.00.0-0.1-0.10.1
Heart weight0.30.40.40.50.6-0.7
Left kidney weight0.10.20.3-0.6-0.50.3
Right kidney weight0.00.10.1-0.4-0.20.1
Tail length1.44.35.7-1.7-2.42.1
Length with tail0.51.72.3-1.0-1.51.3
Length without tail1.12.52.61.51.6-1.6
Liver weight, left0.40.61.1-1.1-0.60.6
Liver weight, right0.20.40.5-0.6-0.70.4
Parametrial fat weight0.10.20.40.40.6-0.3
Retroperitoneal fat weight0.30.81.10.81.0-0.9
Intraocular pressure2.73.84.02.02.0-1.9
Extensor digitorum longus weight6.325.226.44.85.1-5.1
Soleus weight0.72.12.51.11.6-1.6
Tibialis anterior weight2.06.97.72.42.8-2.7
Tibia length0.10.40.4-0.6-0.50.6
Number of licking bursts0.40.40.5-0.7-0.70.6
Food consumed during 24 hour testing period0.91.11.31.10.9-1.1
Times rat made contact with spout0.40.50.6-0.5-0.80.7
Mean time between licks in bursts0.91.21.60.81.2-1.3
Mean num. licks in bursts0.40.50.50.70.7-0.6
Std. dev. time between licks in bursts0.50.60.80.60.8-0.9
Water consumed over 24 hours0.30.40.60.80.5-0.6
Indifference point 0 sec0.10.10.3-0.20.1-0.6
Indifference point AUC1.41.61.91.21.3-1.4
Indifference point function ln k0.10.20.20.40.3-0.5
Indifference point function log k0.10.20.20.40.3-0.5
Delay discounting total patch changes 0 sec0.20.40.80.10.5-0.9
Delay discounting total patch changes 12 sec0.10.10.1-0.30.2-0.3
Delay discounting total patch changes 18 sec1.31.72.51.01.3-1.6
Delay discounting total patch changes 24 sec0.20.20.50.10.2-0.7
Delay discounting total patch changes 6 sec0.10.10.3-0.5-0.0-0.1
Delay discounting time to switch 0 sec0.71.11.4-1.1-0.81.2
Delay discounting water rate 0 sec0.71.21.51.20.8-1.2
Delay discounting water rate 12 sec0.00.00.0-0.1-0.0-0.1
Delay discounting water rate 18 sec0.70.90.9-1.0-1.00.8
Delay discounting water rate 24 sec0.00.00.00.10.00.1
Delay discounting water rate 6 sec0.00.00.0-0.1-0.00.0
Locomotor activity0.20.30.3-0.5-0.40.6
Locomotor testing distance1.52.62.9-1.7-1.31.7
Locomotor testing rearing2.23.54.1-1.8-1.82.0
Light reinforcement 13.76.77.92.42.6-2.8
Light reinforcement 21.41.82.21.01.5-1.5
Reaction time number correct0.81.21.31.11.0-1.1
Reaction time mean minus median1.72.22.5-1.5-1.31.6
Reaction time mean minus median AUC1.72.22.8-1.4-1.41.7
Reaction time num false alarms1.82.52.81.61.5-1.7
Reaction time num false alarms AUC2.53.53.91.81.8-2.0
Reaction time trials correct on left0.81.21.31.11.0-1.1
Reaction time trials on left0.81.11.21.11.0-1.1
Reaction time mean2.43.33.8-1.6-1.91.9
Reaction time mean AUC1.72.32.7-1.3-1.61.7
Median of all reaction times1.72.42.7-1.3-1.61.6
Reaction time omissions1.11.41.7-1.1-1.21.3
Reaction time false alarm rate0.81.11.21.01.0-1.1
Reaction time premature initiation rate0.10.10.1-0.4-0.40.4
Reaction time premature initiations0.00.00.00.20.2-0.2
Std. dev. reaction times3.04.14.5-2.0-1.92.1
Reaction time trials completed0.81.11.21.11.0-1.1
Reaction time trials AUC0.71.11.21.11.0-1.1
Social response proportion0.10.10.4-0.1-0.70.1
Social responses0.70.91.1-0.7-1.11.0
Social time4.35.76.4-2.3-2.52.3
Conditioned locomotion0.00.00.00.1-0.20.1
Cocaine response after cond. corrected0.91.01.31.20.9-1.0
Cocaine response after cond. not corrected0.80.91.11.10.9-0.9
Cocaine response before conditioning0.00.00.0-0.2-0.00.1
Saline control response0.10.20.30.50.4-0.4
Condit. Reinf. active minus inactive responses0.30.40.6-0.4-0.70.8
Condit. Reinf. active-inactive response ratio1.11.21.4-0.9-1.11.2
Condit. Reinf. active responses0.10.10.20.40.3-0.2
Condit. Reinf. inactive responses0.70.91.10.81.1-1.0
Condit. Reinf. lever presses0.40.50.6-0.7-0.60.8
Condit. Reinf. lever reinforcers received0.20.20.30.60.5-0.4
Pavlov. Cond. lever latency0.81.11.21.11.1-1.0
Pavlov. Cond. magazine entry latency0.91.01.1-1.0-1.01.0
Pavlov. Cond. change in total contacts0.71.01.1-1.0-1.10.9
Pavlov. Cond. index score0.70.91.0-1.0-1.00.9
Pavlov. Cond. latency score0.50.70.7-0.9-0.80.8
Pavlov. Cond. lever contacts2.02.83.1-1.8-1.71.6
Pavlov. Cond. magazine entry number1.62.02.11.41.5-1.3
Pavlov. Cond. intertrial magazine entries4.45.66.02.42.5-2.3
Pavlov. Cond. lever-magazine prob. diff.0.50.70.8-0.9-0.80.8
Pavlov. Cond. response bias2.83.84.2-2.0-2.01.9
Conditioned reinforcement - actives0.10.10.4-0.20.20.6
Conditioned reinforcement - inactives0.20.20.4-0.3-0.40.6
Conditioned locomotion1.41.72.61.11.6-1.1
Intermittent access intake day 1-15 change0.60.60.8-0.6-0.80.9
Intermittent access intake escalation1.21.21.5-0.8-1.21.2
Intermittent access intake escalation 21.61.62.2-1.0-1.21.5
Intermitt. access day 1 inactive lever presses0.00.00.1-0.2-0.10.2
Intermitt. access day 15 inactive lever presses0.50.60.8-0.9-0.20.9
Intermitt. access escalation Index0.00.00.10.2-0.2-0.0
Intermittent access day 1 total infusions0.10.10.40.20.6-0.1
Intermittent access day 15 total infusions0.60.71.0-0.7-0.71.0
Intermittent access terminal intake (last 3 days)0.10.10.3-0.30.00.6
Intermittent access total infusions0.10.10.2-0.3-0.10.5
Intermittent access day 1 locomotion0.20.20.40.20.6-0.2
Intermittent access day 15 total locomotion0.00.00.00.10.2-0.0
Intermittent access total locomotion0.10.20.40.20.6-0.2
Intermittent access standard deviation0.50.50.9-0.6-0.50.9
Cocaine induced anxiety1.31.51.81.21.1-1.3
Post-drug Anxiety2.83.13.51.91.6-1.8
Baseline Anxiety0.00.00.10.20.10.1
Lifetime Intake0.00.10.10.10.40.1
Incentive Sensitization - Responses0.70.71.5-0.8-0.31.2
Incentive Sensitization - Breakpoint0.60.61.2-0.7-0.31.1
Progressive ratio test 1 active lever presses0.70.71.20.71.1-0.7
Progressive ratio test 1 breakpoint0.80.81.40.71.2-0.7
Progressive ratio test 1 inactive lever presses0.10.10.2-0.4-0.00.3
Progressive ratio test 2 active lever presses0.20.20.4-0.20.20.6
Progressive ratio test 2 breakpoint0.10.10.20.10.40.3
Progressive ratio test 2 inactive lever presses0.50.61.0-0.8-0.31.0
Total sessions with >9 infusions2.32.53.31.41.8-1.4
Short access day 1 total inactive lever presses0.40.40.8-0.9-0.10.7
Short access day 10 total inactive lever presses0.60.60.9-0.6-1.00.8
Short access day 1 total infusions0.10.10.30.10.5-0.1
Short access day 10 total infusions0.10.10.30.30.5-0.1
Short access total infusions0.80.91.40.81.2-0.7
Short access day 1 locomotion0.10.20.30.30.2-0.6
Short access day 10 total locomotion0.10.10.3-0.5-0.00.4
Short access total locomotion0.60.60.80.60.9-0.8
Compulsive drug intake1.71.71.8-1.4-1.11.4
One hour access (0.3 mA shock)0.30.30.7-0.4-0.40.8
One hour access (shock baseline)0.00.10.10.3-0.20.2
Number of responses in last shaping day0.60.60.8-0.6-0.90.8
Context. condit. distance diff. score1.21.51.8-0.9-1.31.3
Locomotion velocity, session 10.10.10.20.40.2-0.1
Locomotion distance, session 11.21.61.91.31.4-1.1
Locomotion velocity, session 24.04.75.62.02.4-2.2
Locomotion distance, session 24.05.77.32.22.7-2.3
Locomotion velocity, session 30.10.20.2-0.4-0.40.4
Locomotion distance, session 30.10.10.1-0.3-0.40.3
Stereotopy head waving bouts, day 30.30.30.4-0.6-0.60.5
Stereotopy head waving duration, day 30.10.10.1-0.2-0.40.4
Locomotion velocity, session 70.20.30.50.30.7-0.5
Locomotion distance, session 70.70.91.30.81.1-0.9
Stereotopy head waving bouts, day 70.10.10.2-0.2-0.40.3
Stereotopy head waving duration, day 70.20.20.4-0.3-0.60.5
Locomotion velocity, session 80.00.00.0-0.10.20.0
Locomotion distance, session 80.60.91.20.91.1-0.8
Degree of sensitization distance1.61.61.81.21.4-1.2
Degree of sensitization stereotypy0.10.10.1-0.1-0.30.2
Condit. Reinf. active minus inactive responses0.30.40.80.90.4-0.4
Condit. Reinf. active-inactive response ratio0.20.20.50.70.1-0.1
Condit. Reinf. active responses0.20.30.50.70.4-0.3
Condit. Reinf. inactive responses0.50.60.70.80.8-0.6
Incentive salience index mean0.00.00.10.30.00.0
Condit. Reinf. lever presses0.30.50.6-0.6-0.70.8
Time in familiar zone, hab. session 10.10.00.10.40.1-0.0
Time in novel zone, hab. session 11.31.31.4-1.2-1.21.0
Total zone transitions, hab. session 10.10.20.3-0.6-0.20.3
Total locomotion distance, hab. session 10.81.11.30.91.1-1.1
Locomotion velocity, hab. session 10.60.91.10.81.0-1.0
Time in familiar zone, hab. session 20.50.50.7-0.8-0.60.8
Time in novel zone, hab. session 20.10.10.10.30.0-0.2
Total zone transitions, hab. session 20.50.60.80.70.9-0.7
Total locomotion distance, hab. session 21.82.42.61.61.6-1.5
Locomotion velocity, hab. session 21.52.12.31.41.5-1.4
Novel to familiar place preference ratio0.10.10.20.40.1-0.3
Novelty place preference0.00.10.10.30.1-0.2
Time in novel zone, NPP test0.00.00.00.2-0.10.0
Total zone transitions, NPP test0.50.70.90.80.9-0.7
Total locomotion distance, NPP test0.81.21.41.01.2-1.0
Locomotion velocity, NPP test1.21.72.01.11.4-1.3
Pavlov. Cond. lever latency0.30.40.50.60.7-0.6
Pavlov. Cond. magazine entry latency0.10.10.1-0.2-0.30.4
Pavlov. Cond. change in total contacts0.30.30.40.60.5-0.5
Pavlov. Cond. index score0.10.20.2-0.4-0.40.5
Pavlov. Cond. latency score0.20.30.3-0.5-0.50.6
Pavlov. Cond. lever contacts0.10.20.2-0.4-0.40.4
Pavlov. Cond. magazine entry number0.70.90.90.81.0-1.0
Pavlov. Cond. intertrial magazine entries0.60.70.91.00.8-0.7
Pavlov. Cond. lever-magazine prob. diff.0.00.00.00.0-0.10.1
Pavlov. Cond. response bias0.10.10.2-0.2-0.40.3
Bone: apparent density5.18.58.7-3.0-2.92.9
Bone surface0.30.60.9-0.9-0.60.7
Bone volume2.13.64.1-2.0-1.81.9
Bone: connectivity density1.01.61.9-1.4-1.21.2
Bone: cortical apparent density2.12.73.11.51.6-1.8
Bone: cortical area0.20.30.30.50.5-0.5
Bone: cortical porosity1.61.81.8-1.3-1.41.3
Bone: cortical porosity2.02.12.2-1.4-1.51.5
Bone: cortical thickness0.30.40.50.70.6-0.7
Bone: cortical thickness0.10.10.10.30.4-0.3
Bone: cortical tissue density1.92.52.91.41.6-1.7
Bone: elastic displacement0.60.70.9-1.0-0.70.8
Bone: elastic work0.40.50.6-0.7-0.60.7
Bone: endosteal estimation0.00.00.0-0.1-0.20.1
Bone: endosteal perimeter0.00.00.00.10.1-0.0
Bone: final force0.20.30.40.60.3-0.6
Bone: final moment0.20.30.40.60.3-0.6
Bone: marrow area0.00.00.0-0.0-0.10.1
Bone: maximum diameter0.00.10.1-0.3-0.10.3
Bone: maximum force0.20.40.40.70.5-0.6
Bone: maximum moment0.20.40.40.60.5-0.6
Bone: minimum diameter0.30.60.80.80.7-0.9
Bone: periosteal estimation0.00.00.0-0.0-0.10.0
Bone: periosteal perimeter0.00.00.10.30.1-0.2
Bone: post-yield work0.20.20.3-0.4-0.50.5
Bone: stiffness0.20.30.50.70.3-0.6
Bone: tissue strength0.20.20.30.60.3-0.5
Bone: trabecular number4.06.26.5-2.5-2.42.5
Bone: trabecular spacing3.24.14.42.12.0-2.0
Bone: trabecular thickness5.87.17.3-2.6-2.72.7
Bone: trabecular tissue density0.20.20.3-0.4-0.50.5
Breakpoint value in progressive ratio session0.20.20.2-0.4-0.40.5
Distance traveled before self-admin0.10.10.2-0.5-0.00.4
Distance traveled after self-admin3.23.54.0-2.0-1.71.9
Delta time in closed arm before/after self-admin1.11.01.6-1.3-0.90.8
Delta time in open arm before/after self-admin0.10.10.1-0.1-0.40.4
Diff in mean of infusions in LGA sessions1.11.31.6-1.1-1.31.0
Extinction: sum of active levers before priming0.10.10.10.20.3-0.2
Active lever presses in extinction session 61.61.62.11.50.9-1.3
Delta distance traveled before/after self-admin0.80.81.1-0.9-1.00.8
Delta ambulatory time before/after self-admin0.60.70.8-0.9-0.80.7
Time in closed arm before self-admin0.20.20.40.70.1-0.2
Time in closed arm after self-admin1.01.01.5-0.9-1.20.8
Time in open arm before self-admin0.40.50.80.30.9-0.6
Time in open arm after self-admin0.30.30.5-0.6-0.30.7
Sum of active levers in priming session hrs 5-60.10.10.2-0.5-0.20.4
Time to tail flick, vehicle, before self-admin0.20.20.30.50.5-0.4
Time to tail flick, vehicle, after self-admin0.00.00.00.2-0.00.0
Time to tail flick, test, before self-admin0.70.70.91.00.7-0.8
Time to tail flick, test, after self-admin2.42.53.01.71.4-1.6
Delta time to tail flick, vehicle, before/after SA0.10.10.1-0.2-0.30.2
Delta time to tail flick, test, before/after SA0.10.10.20.40.3-0.4
Ambulatory time before self-admin0.00.00.0-0.10.20.2
Ambulatory time after self-admin0.50.60.9-0.9-0.50.8
Total heroin consumption0.10.10.10.40.1-0.3
Area under the delay curve0.30.40.60.80.5-0.4
Delay disc. indifference point, 0s delay0.10.10.20.40.0-0.5
Delay disc. indifference point, 16s delay0.10.10.20.00.10.5
Delay disc. indifference point, 2s delay0.20.20.30.50.1-0.5
Delay disc. indifference point, 24s delay0.20.20.4-0.2-0.60.5
Delay disc. indifference point, 4s delay0.70.70.91.00.8-0.8
Delay disc. indifference point, 8s delay0.00.00.10.30.1-0.1
Delay discount exponential model param0.30.30.5-0.7-0.40.3
Delay discount hyperbolic model param0.50.50.9-1.0-0.60.6
Fecal boli incidents, locomotor time 13.03.23.31.81.8-1.8
Change in fecal boli incidents, locomotor task0.30.30.5-0.5-0.70.3
Time >=10cm from walls, locomotor time 12.02.02.51.31.6-1.3
Bouts of movement, locomotor time 110.811.912.63.43.5-3.4
Total resting periods, locomotor time 110.812.012.53.53.5-3.4
Rest time, locomotor task time 11.51.62.31.21.5-1.0
Distance moved, locomotor task time 10.40.50.7-0.7-0.80.4
Vertical activity count, locomotor time 11.71.82.0-1.4-1.31.3
Time >=10cm from walls, locomotor time 20.00.00.1-0.10.30.1
Bouts of movement, locomotor time 23.84.15.51.82.4-1.8
Total resting periods, locomotor time 23.43.75.21.72.3-1.8
Rest time, locomotor task time 20.00.00.1-0.3-0.10.2
Distance moved, locomotor task time 20.10.20.30.40.1-0.5
Vertical activity count, locomotor time 20.40.50.60.70.8-0.5
Weight adjusted by age0.30.30.50.40.7-0.6
Seeking ratio, delayed vs. immediate footshock0.10.10.3-0.2-0.30.5
Locomotion in novel chamber7.59.29.43.03.1-3.1
Locomotion in novel chamber post-restriction4.75.67.02.12.6-2.3
Progressive ratio3.03.54.02.01.8-1.8
Food seeking constrained by brief footshock0.00.00.00.10.1-0.0
Seeking ratio, punishment vs. effort1.41.82.2-1.5-1.21.3
Run reversals in cocaine runway, females1.01.01.90.81.4-0.7
Run reversals in cocaine runway, males0.60.60.90.71.0-0.6
Latency to leave start box in cocaine runway2.72.93.61.61.9-1.6
Latency to leave start box in cocaine runway, F0.20.20.50.00.7-0.3
Latency to leave start box in cocaine runway, M5.04.85.32.32.0-2.3
Cd content in liver0.10.10.1-0.3-0.20.3
Co content in liver0.30.30.5-0.2-0.70.7
Cu content in liver0.40.50.8-0.4-0.80.9
Fe content in liver2.73.23.4-1.7-1.81.8
K content in liver1.01.01.20.81.0-1.1
Mg content in liver0.10.10.20.20.4-0.4
Mn content in liver0.20.20.20.40.4-0.5
Na content in liver1.21.31.9-1.4-1.01.0
Rb content in liver3.54.34.82.22.1-2.0
Se content in liver0.40.40.60.60.8-0.6
Sr content in liver0.00.00.00.10.1-0.1
Zn content in liver0.00.00.00.1-0.00.1