Hub : Genes

Kif3c

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression ENSRNOG00000011394 0.06 0.06 1.1e-03 0.02 0.02 0.01 0.01 7.2e-03 6.0e-03 2.6e-02 2.5e-02
2 NAcc mRNA stability ENSRNOG00000011394 0.05 0.05 7.5e-04 0.03 0.03 0.02 0.02 4.5e-03 2.2e-03 6.6e-03 9.0e-03
3 PL gene expression ENSRNOG00000011394 0.05 0.05 2.7e-03 0.02 0.03 0.02 0.02 5.6e-03 3.0e-03 6.6e-03 7.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail2.58.28.42.9-2.92.9
BMI without tail0.61.21.21.1-1.11.1
Body weight2.08.38.42.9-2.92.9
Epididymis fat weight16.839.139.56.3-6.36.2
Glucose0.30.40.40.6-0.60.6
Heart weight4.97.07.12.7-2.62.6
Left kidney weight0.51.51.6-1.21.2-1.3
Right kidney weight0.10.20.20.5-0.50.4
Tail length0.10.40.4-0.60.6-0.6
Length with tail0.10.20.20.4-0.40.5
Length without tail0.00.10.10.2-0.20.2
Liver weight, left1.11.71.71.3-1.31.3
Liver weight, right5.38.88.93.0-3.03.0
Parametrial fat weight10.119.820.34.5-4.54.4
Retroperitoneal fat weight31.3103.4104.610.2-10.210.1
Intraocular pressure4.05.65.82.3-2.42.4
Extensor digitorum longus weight2.08.18.2-2.92.9-2.8
Soleus weight2.57.37.5-2.72.7-2.7
Tibialis anterior weight0.82.72.7-1.61.7-1.6
Tibia length0.82.12.21.5-1.41.4
Number of licking bursts1.31.61.61.3-1.31.2
Food consumed during 24 hour testing period0.00.00.10.2-0.20.2
Times rat made contact with spout0.60.70.7-0.80.8-0.8
Mean time between licks in bursts1.72.42.51.6-1.61.5
Mean num. licks in bursts1.61.91.9-1.41.4-1.3
Std. dev. time between licks in bursts0.80.90.90.9-1.01.0
Water consumed over 24 hours0.00.00.0-0.20.1-0.1
Indifference point 0 sec0.40.70.80.8-0.90.8
Indifference point AUC0.00.00.0-0.10.0-0.1
Indifference point function ln k1.62.32.4-1.51.5-1.5
Indifference point function log k1.62.32.4-1.51.5-1.5
Delay discounting total patch changes 0 sec0.40.60.70.8-0.80.8
Delay discounting total patch changes 12 sec0.91.21.21.1-1.11.0
Delay discounting total patch changes 18 sec0.71.01.01.0-1.01.0
Delay discounting total patch changes 24 sec1.11.41.41.2-1.21.2
Delay discounting total patch changes 6 sec1.72.62.71.6-1.61.6
Delay discounting time to switch 0 sec0.40.60.60.8-0.70.7
Delay discounting water rate 0 sec1.42.32.4-1.51.5-1.4
Delay discounting water rate 12 sec0.10.10.10.3-0.30.3
Delay discounting water rate 18 sec1.21.51.6-1.21.3-1.2
Delay discounting water rate 24 sec0.00.10.10.2-0.20.3
Delay discounting water rate 6 sec0.20.20.3-0.50.5-0.4
Locomotor activity0.60.91.01.0-1.00.9
Locomotor testing distance0.40.70.80.9-0.80.8
Locomotor testing rearing0.40.60.6-0.80.8-0.8
Light reinforcement 10.50.90.9-0.90.9-1.0
Light reinforcement 21.41.81.9-1.41.3-1.3
Reaction time number correct0.10.20.2-0.50.5-0.4
Reaction time mean minus median0.00.00.00.2-0.20.1
Reaction time mean minus median AUC0.10.20.20.4-0.40.4
Reaction time num false alarms1.52.12.11.4-1.41.4
Reaction time num false alarms AUC1.52.12.21.5-1.51.5
Reaction time trials correct on left0.10.20.2-0.50.5-0.4
Reaction time trials on left0.10.20.2-0.50.5-0.4
Reaction time mean0.00.10.10.3-0.30.2
Reaction time mean AUC0.00.00.00.1-0.10.1
Median of all reaction times0.00.00.00.1-0.10.1
Reaction time omissions0.30.40.40.6-0.60.6
Reaction time false alarm rate2.02.92.91.7-1.71.7
Reaction time premature initiation rate0.10.20.20.4-0.40.4
Reaction time premature initiations0.00.00.00.1-0.10.2
Std. dev. reaction times0.30.40.40.6-0.60.6
Reaction time trials completed0.10.20.2-0.50.5-0.4
Reaction time trials AUC0.20.20.3-0.50.5-0.4
Social response proportion0.10.10.1-0.20.3-0.3
Social responses0.10.20.20.4-0.40.4
Social time0.10.10.1-0.20.3-0.3
Conditioned locomotion3.64.34.3-2.12.1-2.1
Cocaine response after cond. corrected0.20.20.2-0.40.4-0.4
Cocaine response after cond. not corrected0.70.80.8-0.90.9-0.9
Cocaine response before conditioning2.12.52.6-1.61.6-1.6
Saline control response1.62.22.2-1.51.5-1.5
Condit. Reinf. active minus inactive responses1.31.61.6-1.31.3-1.2
Condit. Reinf. active-inactive response ratio0.70.70.8-0.90.9-0.8
Condit. Reinf. active responses0.71.01.0-1.01.0-1.0
Condit. Reinf. inactive responses0.10.20.2-0.40.4-0.4
Condit. Reinf. lever presses1.01.41.4-1.21.2-1.2
Condit. Reinf. lever reinforcers received0.60.90.9-1.00.9-0.9
Pavlov. Cond. lever latency0.71.01.01.0-1.01.0
Pavlov. Cond. magazine entry latency0.00.00.00.1-0.10.1
Pavlov. Cond. change in total contacts0.00.00.0-0.20.1-0.1
Pavlov. Cond. index score0.30.40.4-0.60.6-0.6
Pavlov. Cond. latency score0.30.40.4-0.60.6-0.6
Pavlov. Cond. lever contacts0.20.20.3-0.50.5-0.5
Pavlov. Cond. magazine entry number0.10.10.1-0.30.3-0.3
Pavlov. Cond. intertrial magazine entries2.53.33.41.8-1.81.8
Pavlov. Cond. lever-magazine prob. diff.0.10.10.1-0.30.3-0.3
Pavlov. Cond. response bias0.30.40.4-0.60.6-0.7
Conditioned reinforcement - actives3.83.73.8-1.92.0-1.9
Conditioned reinforcement - inactives6.06.86.9-2.62.6-2.6
Conditioned locomotion3.94.74.8-2.22.2-2.1
Intermittent access intake day 1-15 change1.91.91.9-1.41.4-1.3
Intermittent access intake escalation1.11.01.1-1.01.0-1.0
Intermittent access intake escalation 20.00.00.10.2-0.20.2
Intermitt. access day 1 inactive lever presses0.10.10.1-0.40.3-0.3
Intermitt. access day 15 inactive lever presses1.61.71.9-1.31.3-1.4
Intermitt. access escalation Index3.02.72.81.7-1.71.6
Intermittent access day 1 total infusions3.53.94.2-1.92.0-2.0
Intermittent access day 15 total infusions4.34.84.9-2.22.2-2.2
Intermittent access terminal intake (last 3 days)3.63.94.1-2.02.0-2.0
Intermittent access total infusions5.15.65.8-2.32.4-2.4
Intermittent access day 1 locomotion2.62.72.7-1.71.6-1.6
Intermittent access day 15 total locomotion0.40.40.4-0.60.6-0.6
Intermittent access total locomotion1.01.11.1-1.11.1-1.0
Intermittent access standard deviation0.70.80.8-0.90.9-0.9
Cocaine induced anxiety0.00.00.0-0.20.2-0.2
Post-drug Anxiety1.41.51.61.2-1.21.3
Baseline Anxiety1.41.51.51.2-1.21.2
Lifetime Intake5.76.46.6-2.52.5-2.6
Incentive Sensitization - Responses1.81.81.8-1.31.3-1.4
Incentive Sensitization - Breakpoint1.21.21.2-1.11.1-1.1
Progressive ratio test 1 active lever presses2.93.03.1-1.71.7-1.8
Progressive ratio test 1 breakpoint2.12.22.3-1.51.5-1.5
Progressive ratio test 1 inactive lever presses5.35.75.8-2.42.4-2.4
Progressive ratio test 2 active lever presses2.42.62.7-1.61.6-1.6
Progressive ratio test 2 breakpoint2.52.82.9-1.71.7-1.7
Progressive ratio test 2 inactive lever presses3.23.73.8-1.91.9-1.9
Total sessions with >9 infusions7.07.67.7-2.82.8-2.7
Short access day 1 total inactive lever presses2.42.72.8-1.61.7-1.6
Short access day 10 total inactive lever presses0.10.10.10.3-0.30.2
Short access day 1 total infusions4.64.95.0-2.22.2-2.2
Short access day 10 total infusions6.47.17.3-2.62.6-2.7
Short access total infusions5.05.55.6-2.32.3-2.4
Short access day 1 locomotion5.55.85.9-2.42.4-2.4
Short access day 10 total locomotion1.61.81.8-1.41.3-1.3
Short access total locomotion2.52.62.6-1.61.6-1.6
Compulsive drug intake4.04.04.12.0-2.02.0
One hour access (0.3 mA shock)2.22.52.6-1.61.6-1.5
One hour access (shock baseline)6.67.67.8-2.82.8-2.7
Number of responses in last shaping day2.82.82.9-1.71.7-1.7
Context. condit. distance diff. score0.20.20.2-0.40.5-0.5
Locomotion velocity, session 10.60.60.70.8-0.80.8
Locomotion distance, session 10.30.40.5-0.70.7-0.6
Locomotion velocity, session 20.00.00.10.2-0.20.2
Locomotion distance, session 20.00.10.10.2-0.20.3
Locomotion velocity, session 30.00.00.0-0.10.1-0.2
Locomotion distance, session 30.00.00.00.2-0.20.2
Stereotopy head waving bouts, day 32.02.52.5-1.61.6-1.6
Stereotopy head waving duration, day 30.40.50.6-0.70.7-0.8
Locomotion velocity, session 70.00.00.00.1-0.20.1
Locomotion distance, session 70.81.11.11.0-1.11.0
Stereotopy head waving bouts, day 70.00.00.0-0.00.0-0.1
Stereotopy head waving duration, day 70.40.50.5-0.70.7-0.7
Locomotion velocity, session 80.50.60.6-0.80.8-0.8
Locomotion distance, session 80.30.40.4-0.70.7-0.6
Degree of sensitization distance0.90.90.90.9-0.90.9
Degree of sensitization stereotypy0.30.30.30.5-0.50.5
Condit. Reinf. active minus inactive responses2.32.62.71.6-1.61.6
Condit. Reinf. active-inactive response ratio2.12.32.41.5-1.51.5
Condit. Reinf. active responses0.20.20.30.5-0.50.5
Condit. Reinf. inactive responses1.21.41.5-1.21.2-1.1
Incentive salience index mean0.30.30.30.6-0.60.6
Condit. Reinf. lever presses0.60.80.8-0.90.9-0.9
Time in familiar zone, hab. session 10.80.80.80.9-0.90.8
Time in novel zone, hab. session 10.30.30.30.5-0.50.5
Total zone transitions, hab. session 10.10.20.2-0.40.4-0.4
Total locomotion distance, hab. session 10.70.91.0-1.01.0-0.9
Locomotion velocity, hab. session 11.31.81.9-1.41.4-1.3
Time in familiar zone, hab. session 20.30.30.30.6-0.60.5
Time in novel zone, hab. session 20.00.00.00.1-0.10.1
Total zone transitions, hab. session 20.20.20.30.5-0.50.5
Total locomotion distance, hab. session 20.20.30.30.5-0.50.6
Locomotion velocity, hab. session 20.10.10.20.3-0.30.4
Novel to familiar place preference ratio0.30.40.40.6-0.60.6
Novelty place preference0.60.70.70.8-0.80.8
Time in novel zone, NPP test0.60.60.60.7-0.80.8
Total zone transitions, NPP test0.81.11.1-1.11.1-1.0
Total locomotion distance, NPP test1.31.71.8-1.41.3-1.3
Locomotion velocity, NPP test1.62.42.4-1.61.6-1.5
Pavlov. Cond. lever latency0.50.60.60.8-0.80.8
Pavlov. Cond. magazine entry latency0.00.00.10.2-0.20.2
Pavlov. Cond. change in total contacts0.00.00.0-0.20.2-0.2
Pavlov. Cond. index score0.10.10.1-0.30.3-0.2
Pavlov. Cond. latency score0.00.00.0-0.10.1-0.1
Pavlov. Cond. lever contacts0.40.50.5-0.70.7-0.7
Pavlov. Cond. magazine entry number0.00.00.00.1-0.0-0.0
Pavlov. Cond. intertrial magazine entries2.02.42.4-1.51.6-1.6
Pavlov. Cond. lever-magazine prob. diff.0.40.50.5-0.70.7-0.7
Pavlov. Cond. response bias0.91.21.2-1.11.1-1.1
Bone: apparent density3.05.05.1-2.32.2-2.2
Bone surface0.61.01.0-1.01.0-1.0
Bone volume1.62.82.8-1.71.7-1.6
Bone: connectivity density1.93.03.0-1.71.7-1.7
Bone: cortical apparent density0.00.00.0-0.10.1-0.0
Bone: cortical area0.00.10.10.2-0.20.2
Bone: cortical porosity3.74.04.1-2.02.0-2.0
Bone: cortical porosity2.93.13.2-1.81.8-1.8
Bone: cortical thickness0.30.50.50.7-0.70.7
Bone: cortical thickness0.50.50.6-0.80.7-0.7
Bone: cortical tissue density0.00.00.00.00.00.0
Bone: elastic displacement1.51.71.7-1.31.3-1.3
Bone: elastic work0.40.50.5-0.70.7-0.7
Bone: endosteal estimation0.10.20.2-0.40.4-0.4
Bone: endosteal perimeter0.00.00.0-0.10.0-0.1
Bone: final force0.00.00.00.2-0.20.1
Bone: final moment0.00.00.00.1-0.10.1
Bone: marrow area0.10.20.2-0.40.4-0.5
Bone: maximum diameter0.00.00.0-0.00.0-0.0
Bone: maximum force0.00.00.00.1-0.10.1
Bone: maximum moment0.00.00.00.1-0.10.1
Bone: minimum diameter0.50.90.91.0-0.90.9
Bone: periosteal estimation0.10.20.2-0.40.4-0.4
Bone: periosteal perimeter0.00.00.00.1-0.10.1
Bone: post-yield work1.82.52.6-1.51.6-1.6
Bone: stiffness0.10.20.20.4-0.40.4
Bone: tissue strength0.70.70.70.8-0.80.8
Bone: trabecular number3.35.25.3-2.32.3-2.3
Bone: trabecular spacing0.81.11.11.1-1.01.0
Bone: trabecular thickness0.50.60.6-0.80.8-0.7
Bone: trabecular tissue density0.10.10.1-0.30.4-0.3
Breakpoint value in progressive ratio session1.01.21.2-1.11.1-1.1
Distance traveled before self-admin0.10.10.1-0.30.3-0.3
Distance traveled after self-admin0.20.20.20.4-0.40.4
Delta time in closed arm before/after self-admin0.20.20.30.5-0.50.4
Delta time in open arm before/after self-admin0.00.00.0-0.20.2-0.1
Diff in mean of infusions in LGA sessions0.00.00.1-0.20.2-0.2
Extinction: sum of active levers before priming0.50.60.6-0.70.7-0.8
Active lever presses in extinction session 62.01.91.9-1.41.4-1.4
Delta distance traveled before/after self-admin1.61.71.81.3-1.31.3
Delta ambulatory time before/after self-admin0.30.30.30.6-0.60.6
Time in closed arm before self-admin0.10.10.10.2-0.20.3
Time in closed arm after self-admin0.50.60.60.7-0.80.8
Time in open arm before self-admin0.00.00.00.2-0.20.1
Time in open arm after self-admin0.10.10.2-0.40.4-0.4
Sum of active levers in priming session hrs 5-60.10.10.10.2-0.20.2
Time to tail flick, vehicle, before self-admin0.40.40.40.6-0.60.6
Time to tail flick, vehicle, after self-admin6.97.47.42.7-2.72.7
Time to tail flick, test, before self-admin1.31.31.4-1.21.2-1.1
Time to tail flick, test, after self-admin1.11.21.2-1.11.1-1.1
Delta time to tail flick, vehicle, before/after SA2.72.62.71.6-1.61.6
Delta time to tail flick, test, before/after SA1.71.51.6-1.21.2-1.3
Ambulatory time before self-admin0.10.10.1-0.20.3-0.2
Ambulatory time after self-admin0.10.10.10.2-0.20.3
Total heroin consumption1.41.71.8-1.31.3-1.3
Area under the delay curve0.00.00.00.2-0.20.2
Delay disc. indifference point, 0s delay1.01.01.11.0-1.01.0
Delay disc. indifference point, 16s delay0.10.10.10.2-0.30.2
Delay disc. indifference point, 2s delay0.10.10.10.4-0.40.3
Delay disc. indifference point, 24s delay2.72.62.7-1.61.6-1.6
Delay disc. indifference point, 4s delay0.20.30.30.5-0.50.5
Delay disc. indifference point, 8s delay0.00.00.0-0.00.0-0.1
Delay discount exponential model param0.00.00.0-0.00.00.0
Delay discount hyperbolic model param0.00.00.0-0.10.1-0.1
Fecal boli incidents, locomotor time 13.23.53.6-1.91.9-1.9
Change in fecal boli incidents, locomotor task3.43.23.31.8-1.81.8
Time >=10cm from walls, locomotor time 10.50.50.5-0.70.7-0.7
Bouts of movement, locomotor time 10.00.00.0-0.10.1-0.0
Total resting periods, locomotor time 10.00.00.0-0.10.1-0.1
Rest time, locomotor task time 10.00.00.0-0.10.1-0.1
Distance moved, locomotor task time 10.20.20.20.4-0.40.4
Vertical activity count, locomotor time 10.20.20.20.4-0.40.5
Time >=10cm from walls, locomotor time 21.71.81.9-1.41.3-1.4
Bouts of movement, locomotor time 20.50.60.60.7-0.80.8
Total resting periods, locomotor time 20.70.70.70.8-0.80.9
Rest time, locomotor task time 20.00.00.00.1-0.10.1
Distance moved, locomotor task time 20.00.00.0-0.20.2-0.2
Vertical activity count, locomotor time 20.40.40.4-0.60.6-0.7
Weight adjusted by age0.30.30.30.5-0.60.5
Seeking ratio, delayed vs. immediate footshock0.00.00.00.0-0.10.0
Locomotion in novel chamber0.40.50.50.7-0.70.7
Locomotion in novel chamber post-restriction2.53.03.01.7-1.71.7
Progressive ratio0.20.30.3-0.60.5-0.5
Food seeking constrained by brief footshock16.319.820.0-4.54.4-4.5
Seeking ratio, punishment vs. effort1.41.71.8-1.31.3-1.3
Run reversals in cocaine runway, females0.40.30.4-0.60.6-0.6
Run reversals in cocaine runway, males1.11.11.1-1.01.0-1.0
Latency to leave start box in cocaine runway0.20.30.3-0.50.5-0.6
Latency to leave start box in cocaine runway, F0.00.00.1-0.10.2-0.3
Latency to leave start box in cocaine runway, M1.71.61.7-1.31.3-1.3
Cd content in liver0.40.40.40.6-0.60.6
Co content in liver4.75.55.6-2.32.4-2.3
Cu content in liver0.10.10.1-0.30.3-0.3
Fe content in liver0.20.20.2-0.40.4-0.4
K content in liver1.81.81.91.4-1.41.3
Mg content in liver1.51.61.71.3-1.31.2
Mn content in liver0.20.20.20.4-0.50.4
Na content in liver2.12.32.3-1.51.5-1.5
Rb content in liver0.40.50.50.7-0.70.7
Se content in liver0.70.90.90.9-0.90.9
Sr content in liver0.10.00.00.2-0.20.2
Zn content in liver1.31.41.41.2-1.21.2