Blm

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression ENSRNOG00000011213 0.14 0.08 1.0e-08 0.1 0.1 0.11 0.11 1.0e-09 7.2e-10 2.0e-10 1.1e-10
2 PL gene expression ENSRNOG00000011213 0.05 0.03 1.3e-03 0.03 0.04 0.04 0.04 5.3e-03 9.6e-04 2.4e-04 4.0e-04
3 Liver gene expression ENSRNOG00000011213 0.17 0.08 7.5e-12 0.1 0.08 0.09 0.09 6.7e-11 3.1e-09 2.4e-10 1.2e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density1.93.25.6-1.8-2.40.9
Area under the delay curve0.60.71.00.40.91.0
BMI with tail1.34.16.31.92.5-1.6
BMI without tail2.65.48.72.72.9-0.6
Body weight0.10.20.7-0.00.80.2
Weight adjusted by age0.30.40.6-0.7-0.80.2
Bone surface0.91.63.0-1.1-1.70.9
Bone volume1.11.83.5-1.1-1.90.8
Breakpoint value in progressive ratio session0.60.71.20.91.10.3
Number of licking bursts0.20.20.5-0.0-0.5-0.7
Context. condit. distance diff. score0.20.30.4-0.2-0.70.7
Locomotion velocity, session 10.20.20.20.50.4-0.4
Locomotion distance, session 10.00.00.10.2-0.00.2
Locomotion velocity, session 20.20.20.30.40.50.5
Locomotion distance, session 20.00.00.10.0-0.20.3
Locomotion velocity, session 30.91.11.71.31.10.5
Locomotion distance, session 31.41.52.91.71.20.2
Stereotopy head waving bouts, day 34.55.47.6-2.7-2.81.2
Stereotopy head waving duration, day 30.70.81.40.90.4-1.2
Locomotion velocity, session 71.71.83.31.41.80.4
Locomotion distance, session 70.81.01.81.31.1-0.0
Stereotopy head waving bouts, day 70.70.81.5-0.8-1.20.4
Stereotopy head waving duration, day 70.10.10.30.60.30.0
Locomotion velocity, session 81.92.33.82.01.7-0.1
Locomotion distance, session 80.60.81.9-0.4-0.61.4
Degree of sensitization distance0.10.10.30.00.2-0.6
Degree of sensitization stereotypy0.10.10.4-0.2-0.10.6
Conditioned locomotion1.41.62.3-1.5-1.30.9
Cocaine response after cond. corrected0.30.30.7-0.8-0.5-0.2
Cocaine response after cond. not corrected0.10.10.2-0.4-0.1-0.1
Cocaine response before conditioning0.20.20.6-0.0-0.20.8
Saline control response2.12.84.11.42.01.5
Bone: connectivity density2.43.86.9-2.1-2.60.5
Bone: cortical apparent density0.20.20.3-0.20.60.5
Bone: cortical area3.04.55.9-2.0-1.92.4
Bone: cortical porosity0.40.41.00.40.2-1.0
Bone: cortical porosity0.30.30.70.40.3-0.8
Bone: cortical thickness1.52.52.8-1.6-1.51.7
Bone: cortical thickness2.42.94.7-1.9-2.2-0.2
Bone: cortical tissue density0.10.10.2-0.30.40.4
Condit. Reinf. active minus inactive responses1.61.73.8-1.2-0.31.9
Condit. Reinf. active-inactive response ratio0.50.50.8-0.4-0.70.9
Condit. Reinf. active responses1.41.83.5-1.3-0.21.9
Condit. Reinf. inactive responses0.20.20.4-0.40.40.6
Incentive salience index mean2.42.97.7-0.90.42.8
Condit. Reinf. lever presses2.53.47.70.11.62.8
Condit. Reinf. active minus inactive responses0.30.41.1-0.40.01.1
Condit. Reinf. active-inactive response ratio0.40.40.8-0.9-0.50.4
Condit. Reinf. active responses0.70.92.50.10.51.6
Condit. Reinf. inactive responses1.72.13.41.21.21.8
Condit. Reinf. lever presses3.95.38.52.92.7-0.3
Condit. Reinf. lever reinforcers received0.91.33.60.20.61.9
Conditioned reinforcement - actives0.20.10.4-0.6-0.2-0.1
Conditioned reinforcement - inactives2.93.35.6-2.4-2.00.3
Conditioned locomotion0.60.71.8-0.4-0.4-1.3
Patch foraging indifference point 0 sec0.10.20.50.70.20.4
Patch foraging indifference point AUC0.91.11.8-1.1-1.30.4
Delay disc. indifference point, 0s delay1.21.32.3-1.5-1.00.7
Delay disc. indifference point, 16s delay0.30.30.50.70.70.1
Delay disc. indifference point, 2s delay1.01.11.61.31.30.3
Delay disc. indifference point, 24s delay0.10.10.1-0.2-0.20.3
Delay disc. indifference point, 4s delay1.81.92.80.91.51.7
Delay disc. indifference point, 8s delay0.40.40.70.20.80.7
Indifference point function ln k2.43.44.72.21.5-1.8
Indifference point function log k2.43.44.72.21.5-1.8
Patch foraging total patch changes 0 sec0.20.30.90.90.20.0
Patch foraging total patch changes 12 sec4.56.09.3-2.7-3.01.2
Patch foraging total patch changes 18 sec1.72.24.2-1.4-2.00.7
Patch foraging total patch changes 24 sec0.40.51.1-0.3-0.61.0
Patch foraging total patch changes 6 sec1.42.15.3-0.8-0.62.3
Patch foraging time to switch 0 sec0.81.21.6-1.1-1.20.8
Patch foraging water rate 0 sec0.91.41.71.31.3-0.9
Patch foraging water rate 12 sec5.38.015.62.93.9-0.2
Patch foraging water rate 18 sec5.26.910.93.03.3-0.9
Patch foraging water rate 24 sec1.01.41.81.21.3-1.0
Patch foraging water rate 6 sec2.43.56.61.82.6-0.8
Seeking ratio, delayed vs. immediate footshock10.612.120.7-4.5-2.72.9
Distance traveled before self-admin2.22.44.8-1.4-0.72.2
Distance traveled after self-admin4.14.58.9-1.7-1.33.0
Extensor digitorum longus weight0.31.22.41.11.60.2
Bone: elastic displacement1.71.94.5-2.1-0.90.6
Bone: elastic work0.81.11.8-1.3-0.71.0
Bone: endosteal estimation0.71.63.9-0.9-2.0-0.2
Bone: endosteal perimeter1.02.03.4-1.5-1.80.6
Epididymis fat weight0.51.12.0-1.40.21.1
Delta time in closed arm before/after self-admin0.30.30.6-0.8-0.4-0.2
Delta time in open arm before/after self-admin1.71.62.61.61.50.1
Diff in mean of infusions in LGA sessions0.50.51.50.10.01.2
Delay discount exponential model param0.80.91.4-0.5-1.0-1.2
Extinction: sum of active levers before priming0.50.50.8-0.8-0.20.9
Active lever presses in extinction session 60.20.20.6-0.8-0.10.1
Bone: final force1.22.02.3-1.3-1.51.5
Bone: final moment1.22.12.3-1.3-1.51.5
Food consumed during 24 hour testing period0.30.41.1-0.0-1.00.1
Glucose0.20.40.9-0.2-0.4-1.0
Heart weight0.10.10.2-0.5-0.1-0.3
Delay discount hyperbolic model param1.01.11.4-0.7-1.2-1.1
Intermittent access intake day 1-15 change0.70.71.1-0.7-0.61.1
Intermittent access intake escalation1.00.91.2-1.0-0.81.1
Intermittent access intake escalation 22.02.02.8-1.7-1.41.2
Intermitt. access day 1 inactive lever presses1.71.82.8-1.7-0.61.5
Intermitt. access day 15 inactive lever presses2.32.54.5-2.1-1.21.3
Intermitt. access escalation Index0.30.20.30.60.50.3
Intermittent access day 1 total infusions0.50.61.4-1.2-0.7-0.2
Intermittent access day 15 total infusions0.70.81.7-1.3-0.70.3
Intermittent access terminal intake (last 3 days)0.60.71.3-1.2-0.70.4
Intermittent access total infusions0.91.02.4-1.5-0.80.1
Intermittent access day 1 locomotion0.50.51.2-1.1-0.50.2
Intermittent access day 15 total locomotion1.21.32.1-1.3-0.11.4
Intermittent access total locomotion0.60.71.5-1.2-0.70.3
Intermittent access standard deviation2.62.85.1-1.8-2.30.1
Left kidney weight0.51.42.7-1.7-1.20.5
Right kidney weight0.00.10.3-0.50.00.2
Cocaine induced anxiety0.10.20.4-0.3-0.10.6
Post-drug Anxiety1.92.14.4-1.3-0.42.1
Baseline Anxiety0.80.92.1-0.30.61.4
Tail length0.51.54.2-0.5-0.32.0
Length with tail1.13.96.0-2.0-1.32.4
Length without tail0.81.72.8-1.7-1.30.6
Times rat made contact with spout0.10.10.2-0.10.40.0
Lifetime Intake0.60.71.7-1.3-0.60.2
Liver weight, left0.50.81.7-1.3-0.70.4
Liver weight, right2.94.86.7-2.6-1.82.1
Locomotor activity3.25.17.52.72.1-1.8
Locomotor testing distance2.44.05.32.32.3-1.2
Locomotor testing rearing0.91.52.31.51.40.2
Locomotion in novel chamber0.50.72.0-0.10.01.4
Locomotion in novel chamber post-restriction0.40.40.70.90.4-0.6
Fecal boli incidents, locomotor time 13.64.06.4-2.5-2.30.4
Change in fecal boli incidents, locomotor task1.31.32.21.51.1-0.6
Time >=10cm from walls, locomotor time 11.41.42.40.61.61.2
Bouts of movement, locomotor time 10.50.51.5-0.40.01.2
Total resting periods, locomotor time 10.91.02.5-0.7-0.21.6
Rest time, locomotor task time 13.03.33.7-1.9-1.61.9
Distance moved, locomotor task time 11.31.41.61.31.3-1.0
Vertical activity count, locomotor time 11.61.72.31.51.0-1.3
Time >=10cm from walls, locomotor time 20.50.61.10.40.61.0
Bouts of movement, locomotor time 21.01.02.4-0.7-1.60.4
Total resting periods, locomotor time 21.81.94.2-1.1-2.10.2
Rest time, locomotor task time 25.86.79.5-3.1-3.11.1
Distance moved, locomotor task time 20.30.30.50.70.7-0.0
Vertical activity count, locomotor time 20.50.50.80.90.6-0.5
Light reinforcement 13.36.111.9-2.5-3.50.2
Light reinforcement 24.35.77.6-2.7-2.71.4
Bone: marrow area0.71.63.9-0.8-2.0-0.3
Bone: maximum diameter1.01.82.4-1.0-1.51.5
Bone: maximum force1.01.82.3-1.1-1.31.5
Bone: maximum moment0.91.62.1-1.1-1.21.4
Mean time between licks in bursts3.44.87.5-2.7-2.60.6
Mean num. licks in bursts0.20.20.4-0.20.60.5
Cd content in liver3.03.35.1-2.0-2.3-0.9
Co content in liver0.20.30.4-0.6-0.5-0.5
Cu content in liver0.91.01.70.51.11.3
Fe content in liver0.00.10.1-0.2-0.20.3
K content in liver0.80.81.81.30.80.3
Mg content in liver1.92.04.12.01.1-0.9
Mn content in liver0.40.40.6-0.5-0.60.8
Na content in liver1.71.83.92.01.10.3
Rb content in liver1.62.02.51.61.2-1.4
Se content in liver0.30.30.5-0.6-0.70.4
Sr content in liver1.41.32.11.51.2-0.5
Zn content in liver0.00.10.1-0.1-0.40.1
Bone: minimum diameter3.25.810.3-2.5-3.21.0
Time in familiar zone, hab. session 10.60.60.60.80.8-0.8
Time in novel zone, hab. session 10.30.30.7-0.9-0.50.2
Total zone transitions, hab. session 11.72.43.11.81.71.0
Total locomotion distance, hab. session 18.311.915.8-4.0-3.42.9
Locomotion velocity, hab. session 19.012.916.1-4.0-3.33.4
Time in familiar zone, hab. session 20.80.81.2-0.4-1.0-1.1
Time in novel zone, hab. session 20.30.30.70.20.80.5
Total zone transitions, hab. session 22.02.64.52.11.70.5
Total locomotion distance, hab. session 27.49.811.9-3.5-3.32.5
Locomotion velocity, hab. session 27.09.511.2-3.3-3.12.7
Novel to familiar place preference ratio0.30.30.70.80.1-0.5
Novelty place preference0.30.30.70.80.2-0.5
Time in novel zone, NPP test0.70.71.11.10.6-0.8
Total zone transitions, NPP test0.30.40.40.50.60.6
Total locomotion distance, NPP test12.217.024.9-5.0-4.42.5
Locomotion velocity, NPP test13.319.126.8-5.2-4.82.7
Intraocular pressure0.20.30.70.80.2-0.4
Delta distance traveled before/after self-admin0.20.20.50.1-0.70.0
Delta ambulatory time before/after self-admin0.30.30.8-0.3-0.9-0.0
Parametrial fat weight0.71.32.70.11.71.1
Pavlov. Cond. lever latency4.15.215.00.5-0.5-3.9
Pavlov. Cond. magazine entry latency4.55.813.8-1.8-0.53.7
Pavlov. Cond. change in total contacts10.110.719.8-3.0-1.84.4
Pavlov. Cond. index score4.86.116.8-1.20.14.1
Pavlov. Cond. latency score4.76.017.0-1.00.34.1
Pavlov. Cond. lever contacts4.14.813.9-0.70.33.7
Pavlov. Cond. magazine entry number2.83.59.70.9-0.3-3.1
Pavlov. Cond. intertrial magazine entries0.10.10.10.10.40.4
Pavlov. Cond. lever-magazine prob. diff.5.06.316.7-1.5-0.14.1
Pavlov. Cond. response bias4.25.111.2-1.9-0.83.3
Pavlov. Cond. lever latency2.43.34.5-1.6-2.1-1.7
Pavlov. Cond. magazine entry latency1.71.93.01.01.71.3
Pavlov. Cond. change in total contacts2.63.66.21.11.92.5
Pavlov. Cond. index score3.44.46.11.72.52.0
Pavlov. Cond. latency score3.03.75.01.62.21.9
Pavlov. Cond. lever contacts3.85.27.82.32.81.6
Pavlov. Cond. magazine entry number2.22.74.4-1.6-2.1-1.0
Pavlov. Cond. intertrial magazine entries0.00.10.20.1-0.00.4
Pavlov. Cond. lever-magazine prob. diff.3.34.36.11.72.51.9
Pavlov. Cond. response bias3.54.97.22.02.71.8
Time in closed arm before self-admin1.21.42.4-1.0-1.01.5
Time in closed arm after self-admin3.03.14.4-2.1-1.91.3
Time in open arm before self-admin0.40.40.8-0.6-0.4-0.9
Time in open arm after self-admin2.22.54.41.72.1-0.3
Bone: periosteal estimation1.53.15.3-1.6-2.31.2
Bone: periosteal perimeter1.62.73.1-1.7-1.81.4
Bone: post-yield work0.10.10.30.6-0.00.2
Progressive ratio test 1 active lever presses0.30.30.7-0.8-0.50.1
Progressive ratio test 1 breakpoint0.30.30.5-0.7-0.50.2
Progressive ratio test 1 inactive lever presses1.51.63.1-1.8-0.21.2
Progressive ratio test 2 active lever presses1.11.12.1-1.4-0.80.8
Progressive ratio test 2 breakpoint1.01.12.1-1.4-0.90.7
Progressive ratio test 2 inactive lever presses1.71.92.9-1.7-0.61.6
Incentive Sensitization - Responses0.50.50.8-0.7-0.20.9
Incentive Sensitization - Breakpoint0.50.50.9-0.8-0.30.9
Sum of active levers in priming session hrs 5-60.40.40.9-0.3-0.6-0.9
Progressive ratio0.20.20.5-0.4-0.10.7
Food seeking constrained by brief footshock0.80.92.4-0.20.61.5
Seeking ratio, punishment vs. effort0.00.00.1-0.10.00.3
Retroperitoneal fat weight0.72.44.4-0.32.11.6
Reaction time number correct0.60.92.40.5-0.2-1.5
Reaction time mean minus median0.40.50.80.60.60.9
Reaction time mean minus median AUC0.30.40.60.50.50.8
Reaction time num false alarms5.37.312.5-3.1-3.5-0.1
Reaction time num false alarms AUC3.14.48.2-2.0-2.9-1.1
Reaction time trials correct on left0.60.92.40.5-0.2-1.5
Reaction time trials on left0.71.02.60.6-0.2-1.6
Reaction time mean0.20.30.60.30.80.6
Reaction time mean AUC0.40.50.90.50.90.7
Median of all reaction times0.10.10.30.10.50.3
Reaction time omissions0.10.20.50.2-0.3-0.7
Reaction time false alarm rate2.02.94.8-2.0-2.2-0.0
Reaction time premature initiation rate0.70.91.60.50.91.3
Reaction time premature initiations0.20.30.50.70.70.3
Std. dev. reaction times1.11.52.21.51.40.6
Reaction time trials completed0.71.02.60.6-0.2-1.6
Reaction time trials AUC0.60.82.30.3-0.3-1.5
Run reversals in cocaine runway, females0.20.20.3-0.5-0.50.4
Run reversals in cocaine runway, males0.90.81.90.71.40.1
Latency to leave start box in cocaine runway2.52.84.6-1.5-2.11.2
Latency to leave start box in cocaine runway, F1.71.83.7-1.3-1.90.2
Latency to leave start box in cocaine runway, M1.61.62.1-1.0-1.31.4
Std. dev. time between licks in bursts0.40.51.20.0-1.1-0.6
Total sessions with >9 infusions1.41.53.4-1.9-1.1-0.1
Short access day 1 total inactive lever presses3.03.35.8-2.4-0.91.9
Short access day 10 total inactive lever presses3.23.56.1-2.0-0.62.5
Short access day 1 total infusions0.60.61.3-1.1-0.60.5
Short access day 10 total infusions0.30.30.6-0.8-0.30.5
Short access total infusions0.40.40.9-0.9-0.40.5
Short access day 1 locomotion2.02.13.2-1.8-1.50.9
Short access day 10 total locomotion0.60.70.9-0.8-1.00.7
Short access total locomotion1.51.52.5-1.4-1.60.2
One hour access (0.3 mA shock)0.60.71.4-1.2-0.8-0.2
Compulsive drug intake0.10.10.3-0.6-0.2-0.0
One hour access (shock baseline)0.20.30.4-0.7-0.6-0.0
Social response proportion0.80.91.10.81.1-0.9
Social responses0.81.12.01.10.4-1.4
Social time1.21.63.21.2-0.3-1.8
Soleus weight1.23.69.3-0.70.93.0
Bone: stiffness1.01.62.1-1.1-1.21.5
Tibialis anterior weight0.30.91.50.31.21.0
Time to tail flick, vehicle, before self-admin0.50.51.1-1.0-0.30.6
Time to tail flick, vehicle, after self-admin0.10.10.30.3-0.30.5
Time to tail flick, test, before self-admin0.90.92.21.50.3-0.6
Time to tail flick, test, after self-admin0.20.20.6-0.2-0.3-0.8
Delta time to tail flick, vehicle, before/after SA2.42.45.72.40.9-0.8
Delta time to tail flick, test, before/after SA1.00.91.7-1.3-0.9-0.4
Tibia length0.61.84.12.00.6-1.0
Ambulatory time before self-admin2.12.24.6-1.4-0.32.1
Ambulatory time after self-admin4.65.111.6-1.7-0.93.4
Bone: tissue strength3.13.04.42.12.0-0.7
Total heroin consumption0.10.10.20.30.40.2
Bone: trabecular number2.53.98.3-1.8-2.90.3
Bone: trabecular spacing3.03.85.92.22.4-0.9
Bone: trabecular thickness1.82.22.3-1.5-1.51.4
Bone: trabecular tissue density0.50.80.90.80.81.0
Water consumed over 24 hours0.00.00.10.20.2-0.1
Number of responses in last shaping day0.20.20.3-0.3-0.5-0.4