Tenm4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000011151 0.23 0.09 0.0e+00 0.12 0.15 0.15 0.15 4.6e-13 2.4e-16 2.6e-16 5.7e-16
2 Adipose intron excision ratio chr1:150845205:150898763 0.08 0.04 2.4e-05 0.02 0.03 0.02 0.02 6.3e-03 6.5e-04 1.6e-03 4.8e-03
3 Adipose mRNA stability ENSRNOG00000011151 0.07 0.04 4.2e-06 0.04 0.04 0.04 0.04 2.7e-05 6.8e-05 6.4e-05 6.2e-05
4 Brain gene expression ENSRNOG00000011151 0.06 0.05 7.1e-03 0.03 0.03 0.04 0.02 1.0e-03 2.1e-03 1.5e-04 5.3e-03
5 Brain isoform ratio ENSRNOT00000107189 0.04 0.03 3.0e-03 0 0.01 0 0.01 9.8e-02 1.4e-02 1.1e-01 4.7e-02
6 Brain intron excision ratio chr1:151047589:151059456 0.04 0.03 4.5e-03 0 0.01 -0 0 1.0e-01 3.1e-02 5.1e-01 1.2e-01
7 Brain intron excision ratio chr1:151150960:151158532 0.04 0.02 5.0e-03 -0 0.01 -0 -0 8.0e-01 5.3e-02 5.1e-01 4.2e-01
8 NAcc isoform ratio ENSRNOT00000015181 0.05 0.03 3.6e-03 0.02 0.04 0.03 0.03 8.4e-03 4.2e-04 2.0e-03 4.4e-03
9 NAcc isoform ratio ENSRNOT00000107189 0.06 0.03 5.5e-04 0.03 0.06 0.04 0.04 2.4e-03 3.4e-05 8.6e-04 3.0e-04
10 NAcc intron excision ratio chr1:151047589:151058146 0.05 0.03 3.4e-03 0.05 0.03 0.04 0.04 2.0e-04 3.1e-03 1.1e-03 5.8e-04
11 NAcc intron excision ratio chr1:151047589:151059456 0.05 0.03 3.9e-03 0.02 0.03 0.02 0.02 1.5e-02 1.5e-03 2.1e-02 9.0e-03
12 OFC mRNA stability ENSRNOG00000011151 0.24 0.11 1.1e-03 0.2 0.13 0.14 0.16 1.7e-05 6.8e-04 4.4e-04 1.2e-04
13 PL gene expression ENSRNOG00000011151 0.06 0.03 2.6e-03 0.04 0.03 0.03 0.03 3.7e-04 1.5e-03 1.7e-03 2.6e-03
14 PL intron excision ratio chr1:151047589:151059456 0.06 0.04 8.1e-03 0.01 0.02 0 0.01 7.1e-02 8.0e-03 1.3e-01 3.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
BMI with tail1.34.19.3-0.81.8-1.8-1.32.12.21.4-2.22.1-3.12.32.9-1.51.8
BMI without tail4.28.928.3-1.42.3-3.6-0.92.93.00.8-2.83.3-4.13.25.3-1.52.8
Body weight2.812.125.1-1.12.7-3.5-1.23.63.72.4-3.83.8-4.83.95.0-2.83.7
Epididymis fat weight1.43.28.5-2.32.6-2.5-0.81.51.9-0.2-1.41.4-2.01.42.90.3-0.5
Glucose0.10.21.10.6-0.20.4-0.1-0.0-0.11.0-0.1-0.30.0-0.1-1.0-0.50.3
Heart weight0.50.81.90.8-0.2-0.91.4-0.9-0.71.00.7-1.3-0.6-1.1-0.80.6-0.6
Left kidney weight0.51.66.60.11.0-2.61.10.40.71.4-0.60.2-2.60.41.7-0.00.6
Right kidney weight0.72.06.8-0.41.6-2.50.71.01.31.7-1.20.6-2.60.91.6-0.60.6
Tail length1.64.917.0-0.11.1-3.91.31.51.80.9-1.52.0-3.21.94.1-0.62.6
Length with tail1.76.315.2-0.61.7-2.80.22.52.61.4-2.62.9-3.22.83.9-1.93.1
Length without tail0.61.33.4-0.10.60.6-0.91.41.21.3-1.51.3-0.61.40.1-1.91.3
Liver weight, left1.62.65.5-0.71.1-1.0-1.31.81.70.7-1.81.9-1.91.92.3-1.71.7
Liver weight, right3.35.410.5-3.23.2-1.2-1.62.83.0-0.1-2.62.7-1.82.63.0-1.20.1
Parametrial fat weight1.83.69.2-1.21.5-0.8-1.62.12.10.2-2.02.5-1.92.43.0-1.61.8
Retroperitoneal fat weight5.016.532.6-3.44.8-4.0-2.44.44.91.9-4.54.3-5.14.45.7-2.52.0
Intraocular pressure1.72.47.02.7-2.20.51.1-1.7-1.91.11.4-1.90.3-1.6-2.0-0.00.5
Extensor digitorum longus weight0.52.27.20.31.1-1.70.41.21.32.2-1.50.9-2.71.31.5-1.31.6
Soleus weight0.82.36.7-0.31.1-1.8-0.11.41.51.3-1.51.4-2.61.62.2-1.01.6
Tibialis anterior weight0.51.64.1-0.31.0-1.2-0.21.31.31.2-1.41.2-2.01.41.6-1.21.3
Tibia length0.71.95.61.9-2.4-0.00.6-1.8-2.0-1.01.8-1.30.6-1.4-0.31.30.3
Number of licking bursts2.12.55.5-2.22.30.0-0.32.12.20.4-2.01.8-0.91.81.3-1.4-0.1
Food consumed during 24 hour testing period2.32.712.22.8-3.51.0-0.7-1.6-2.2-1.11.6-0.70.9-0.8-0.2-0.01.9
Times rat made contact with spout0.80.92.4-0.70.9-0.4-1.51.01.00.4-1.00.9-1.31.01.1-0.70.4
Mean time between licks in bursts1.11.64.60.40.1-2.11.4-1.3-0.80.31.2-1.6-0.5-1.5-0.32.1-1.4
Mean num. licks in bursts1.41.74.42.1-2.0-0.0-0.1-1.7-1.8-0.01.6-1.50.3-1.5-1.01.00.3
Std. dev. time between licks in bursts0.30.43.4-0.30.5-1.80.10.20.40.0-0.20.4-0.50.30.90.60.4
Water consumed over 24 hours0.80.93.5-0.60.40.9-1.91.00.8-0.1-1.01.2-0.31.20.6-1.30.8
Indifference point 0 sec0.50.82.61.6-0.7-0.81.3-0.1-0.21.6-0.1-0.3-0.9-0.1-0.4-0.81.5
Indifference point AUC0.40.41.00.9-1.0-0.70.2-0.8-0.8-0.60.8-0.40.2-0.50.21.00.4
Indifference point function ln k0.30.41.60.8-0.30.6-0.60.20.01.3-0.40.0-0.40.3-0.8-1.20.9
Indifference point function log k0.30.41.60.8-0.30.6-0.60.20.01.3-0.40.0-0.40.3-0.8-1.20.9
Delay discounting total patch changes 0 sec0.50.82.81.7-0.7-0.81.1-0.2-0.31.7-0.0-0.3-0.8-0.1-0.6-0.71.4
Delay discounting total patch changes 12 sec0.60.82.20.6-0.4-1.50.4-1.1-0.9-0.11.0-1.2-0.2-1.1-0.31.5-0.7
Delay discounting total patch changes 18 sec0.81.12.51.6-1.1-1.61.2-1.2-1.00.41.0-1.1-0.4-1.0-0.41.40.4
Delay discounting total patch changes 24 sec0.91.12.40.9-1.0-1.41.3-1.3-1.1-0.61.3-1.1-0.0-1.1-0.01.5-0.3
Delay discounting total patch changes 6 sec0.50.73.40.7-0.30.2-0.10.80.50.8-0.81.0-0.41.00.3-1.41.9
Delay discounting time to switch 0 sec1.11.77.2-2.71.71.1-0.81.21.2-1.6-0.81.20.91.01.00.0-1.4
Delay discounting water rate 0 sec1.11.74.52.1-1.6-0.31.3-1.5-1.50.81.3-1.50.5-1.4-1.70.70.4
Delay discounting water rate 12 sec0.71.03.91.8-0.9-0.10.5-0.2-0.42.0-0.1-0.5-0.6-0.2-1.3-1.01.4
Delay discounting water rate 18 sec0.60.83.91.4-0.3-0.90.00.00.02.0-0.4-0.2-1.30.1-0.3-0.81.4
Delay discounting water rate 24 sec0.60.93.61.9-1.30.3-0.3-0.3-0.61.40.0-0.3-0.2-0.1-1.0-0.91.5
Delay discounting water rate 6 sec0.40.62.91.2-0.90.60.2-0.6-0.70.90.4-0.80.6-0.6-1.7-0.20.3
Locomotor activity0.91.44.70.20.9-1.5-0.91.01.12.2-1.30.6-1.60.90.2-1.21.2
Locomotor testing distance0.81.37.31.10.3-2.70.2-0.10.22.3-0.3-0.5-2.0-0.2-0.00.10.8
Locomotor testing rearing1.42.29.0-0.31.6-3.0-0.70.81.22.1-1.10.4-2.90.71.3-0.30.6
Light reinforcement 10.61.23.9-2.01.9-0.3-0.81.11.4-0.1-1.10.9-0.50.91.0-0.1-0.8
Light reinforcement 20.50.62.0-1.30.80.90.90.10.2-0.90.1-0.01.1-0.2-0.50.6-1.4
Reaction time number correct0.40.62.6-0.50.80.3-1.60.80.81.0-0.90.4-0.40.6-0.3-1.10.0
Reaction time mean minus median0.40.52.10.10.7-1.0-0.50.50.61.4-0.70.1-1.30.40.4-0.50.4
Reaction time mean minus median AUC0.30.42.5-0.10.9-0.4-0.20.40.51.6-0.6-0.2-0.70.1-0.6-0.4-0.2
Reaction time num false alarms0.50.73.2-0.40.2-0.3-0.70.80.7-0.6-0.61.2-0.71.01.8-0.31.0
Reaction time num false alarms AUC0.20.31.40.2-0.6-0.1-0.80.0-0.1-0.90.10.5-0.10.31.20.10.8
Reaction time trials correct on left0.40.62.6-0.50.80.3-1.60.80.81.0-0.90.4-0.40.6-0.3-1.10.0
Reaction time trials on left0.40.62.4-0.60.90.3-1.60.80.81.0-0.90.4-0.40.6-0.3-1.1-0.0
Reaction time mean0.30.51.7-1.31.3-0.10.40.60.8-0.1-0.50.4-0.20.40.60.2-0.8
Reaction time mean AUC0.30.41.5-1.21.10.20.40.60.8-0.3-0.50.50.10.40.50.1-0.7
Median of all reaction times0.40.51.8-1.41.00.20.70.20.4-0.8-0.10.10.50.00.30.7-1.3
Reaction time omissions0.60.82.7-0.91.6-1.01.10.81.11.0-0.80.2-0.90.30.4-0.1-0.5
Reaction time false alarm rate0.20.31.80.1-0.7-0.10.3-0.4-0.4-1.30.50.20.3-0.10.90.70.3
Reaction time premature initiation rate0.91.35.7-0.30.7-2.10.20.60.80.2-0.60.9-1.80.82.40.21.0
Reaction time premature initiations0.71.03.3-0.30.9-1.7-0.40.70.90.6-0.80.8-1.60.81.8-0.20.7
Std. dev. reaction times0.50.71.9-0.41.2-1.30.30.70.91.1-0.80.3-1.40.50.9-0.10.1
Reaction time trials completed0.40.62.4-0.60.90.3-1.60.80.81.0-0.90.4-0.40.6-0.3-1.1-0.0
Reaction time trials AUC0.50.72.2-0.61.0-0.0-1.50.90.91.1-1.00.5-0.70.7-0.1-1.10.1
Social response proportion1.11.23.1-1.81.3-0.3-1.71.01.1-0.8-0.91.2-0.31.01.6-0.5-0.4
Social responses1.82.34.8-1.52.2-1.3-1.01.82.01.1-1.81.5-1.61.61.5-1.00.3
Social time0.70.93.1-1.81.2-0.3-0.60.91.0-1.0-0.71.00.00.91.40.0-0.6
Conditioned locomotion0.40.52.50.10.60.4-0.50.60.61.6-0.80.1-0.10.3-1.2-0.90.2
Cocaine response after cond. corrected0.30.31.1-0.40.2-0.51.0-0.4-0.2-0.60.5-0.4-0.2-0.50.60.6-0.9
Cocaine response after cond. not corrected0.50.62.0-0.30.0-0.30.9-0.8-0.6-0.80.9-0.90.3-0.90.01.1-1.4
Cocaine response before conditioning0.91.13.3-0.6-0.11.10.0-0.6-0.6-1.10.7-0.71.8-0.8-1.51.1-1.6
Saline control response1.21.54.61.20.0-1.40.90.70.62.1-0.90.6-2.00.90.5-1.22.1
Condit. Reinf. active minus inactive responses1.61.99.41.6-0.4-1.73.1-1.1-0.81.70.8-1.6-0.7-1.3-1.20.9-0.1
Condit. Reinf. active-inactive response ratio1.11.14.81.2-0.5-0.82.2-0.9-0.71.20.7-1.3-0.0-1.1-1.40.6-0.2
Condit. Reinf. active responses1.62.38.71.9-0.4-2.62.9-1.0-0.62.10.6-1.4-1.3-1.1-0.60.80.5
Condit. Reinf. inactive responses0.81.04.71.1-0.3-2.20.30.00.11.1-0.20.1-1.70.21.30.11.5
Condit. Reinf. lever presses3.24.415.43.9-2.1-1.42.5-1.7-1.63.21.1-2.1-1.0-1.6-2.3-0.11.7
Condit. Reinf. lever reinforcers received1.92.79.62.1-0.6-2.53.1-1.3-1.02.11.0-1.8-1.1-1.5-1.01.00.3
Pavlov. Cond. lever latency5.06.921.8-4.72.41.8-2.92.32.2-4.0-1.53.01.12.33.3-0.3-1.5
Pavlov. Cond. magazine entry latency2.63.09.22.6-1.3-0.41.8-1.6-1.52.51.1-2.2-0.1-1.8-3.00.50.1
Pavlov. Cond. change in total contacts2.63.610.43.2-1.3-1.62.4-1.6-1.43.20.9-2.2-1.5-1.6-2.00.00.9
Pavlov. Cond. index score4.45.716.94.1-2.2-1.42.7-2.3-2.23.41.6-2.9-0.8-2.3-3.20.50.9
Pavlov. Cond. latency score4.05.114.93.9-2.1-1.12.7-2.1-2.03.21.4-2.7-0.7-2.1-3.10.30.9
Pavlov. Cond. lever contacts4.36.019.14.4-2.0-1.92.7-1.9-1.84.21.1-2.6-1.4-1.9-2.90.01.6
Pavlov. Cond. magazine entry number5.56.815.8-4.02.50.7-2.72.82.7-2.8-2.23.5-0.13.04.0-1.0-0.0
Pavlov. Cond. intertrial magazine entries1.21.58.5-1.10.9-1.7-0.50.91.0-1.0-0.61.3-1.21.12.90.10.6
Pavlov. Cond. lever-magazine prob. diff.4.15.315.64.0-2.1-1.52.7-2.2-2.13.21.5-2.8-0.9-2.2-2.90.50.9
Pavlov. Cond. response bias5.47.521.14.6-2.4-2.02.8-2.7-2.53.81.9-3.4-1.0-2.7-3.61.00.9
Conditioned reinforcement - actives5.75.69.41.3-2.40.80.9-3.0-3.0-2.03.1-2.82.3-2.9-2.12.8-2.1
Conditioned reinforcement - inactives0.20.21.0-0.4-0.20.4-0.7-0.2-0.3-1.00.3-0.00.7-0.10.10.6-0.4
Conditioned locomotion3.23.86.41.0-2.21.20.5-2.4-2.5-2.02.5-2.12.2-2.3-1.71.9-1.6
Intermittent access intake day 1-15 change1.61.63.81.7-1.90.70.3-1.5-1.7-0.41.4-1.31.1-1.3-1.50.80.1
Intermittent access intake escalation1.71.73.11.7-1.80.50.8-1.5-1.7-0.11.5-1.51.0-1.5-1.70.9-0.1
Intermittent access intake escalation 20.80.81.50.2-0.60.10.5-1.1-1.0-0.81.1-1.10.8-1.1-0.71.2-1.1
Intermitt. access day 1 inactive lever presses0.60.62.2-1.10.4-0.4-0.4-0.4-0.2-1.40.5-0.30.5-0.40.61.2-1.5
Intermitt. access day 15 inactive lever presses0.10.11.10.1-0.0-0.4-1.00.00.00.1-0.10.0-0.40.10.30.10.1
Intermitt. access escalation Index0.60.51.2-0.1-0.00.8-1.10.70.50.1-0.70.90.20.90.2-1.11.0
Intermittent access day 1 total infusions0.40.50.90.9-0.8-0.20.1-0.9-0.90.20.8-0.90.1-0.9-0.80.7-0.2
Intermittent access day 15 total infusions2.22.55.31.7-1.70.50.6-1.9-2.0-0.01.8-2.01.2-2.0-2.31.4-0.8
Intermittent access terminal intake (last 3 days)1.51.62.70.9-1.20.20.2-1.6-1.6-0.51.6-1.61.1-1.6-1.51.5-1.1
Intermittent access total infusions1.61.83.40.6-1.20.20.3-1.7-1.6-1.11.7-1.61.2-1.7-1.21.8-1.3
Intermittent access day 1 locomotion1.31.32.8-0.1-0.71.0-0.3-1.1-1.2-1.31.2-1.11.7-1.2-1.31.3-1.5
Intermittent access day 15 total locomotion1.01.12.30.4-0.40.10.7-1.2-1.0-0.01.1-1.50.8-1.5-1.41.3-1.4
Intermittent access total locomotion0.70.82.2-0.1-0.20.20.0-1.0-0.9-0.51.0-1.20.7-1.2-1.01.2-1.5
Intermittent access standard deviation0.40.41.3-0.2-0.3-0.3-0.1-0.7-0.7-1.10.8-0.60.4-0.70.31.1-0.9
Cocaine induced anxiety1.01.23.5-1.51.90.0-0.71.31.50.9-1.40.8-0.71.00.2-1.0-0.5
Post-drug Anxiety0.30.40.9-0.20.7-0.30.50.70.70.9-0.80.4-0.70.60.2-0.70.3
Baseline Anxiety1.81.96.22.5-2.4-0.21.2-1.6-1.8-0.01.5-1.10.4-1.2-0.90.81.2
Lifetime Intake1.92.24.01.0-1.5-0.10.3-1.9-1.9-1.01.9-1.81.0-1.9-1.22.0-1.2
Incentive Sensitization - Responses1.11.13.30.9-0.7-1.00.9-1.3-1.1-0.21.2-1.3-0.0-1.3-0.41.8-0.6
Incentive Sensitization - Breakpoint1.11.13.50.9-0.8-0.90.7-1.4-1.2-0.31.3-1.30.1-1.3-0.41.9-0.7
Progressive ratio test 1 active lever presses0.10.10.6-0.2-0.30.5-0.4-0.2-0.3-0.80.3-0.00.7-0.1-0.00.2-0.2
Progressive ratio test 1 breakpoint0.30.31.1-0.3-0.30.7-0.3-0.3-0.4-1.00.5-0.20.9-0.3-0.20.5-0.6
Progressive ratio test 1 inactive lever presses0.30.31.20.2-0.6-0.0-0.1-0.7-0.7-0.80.7-0.50.5-0.6-0.01.1-0.3
Progressive ratio test 2 active lever presses1.31.43.60.6-0.7-0.51.1-1.5-1.3-0.51.5-1.60.6-1.6-0.81.9-1.3
Progressive ratio test 2 breakpoint0.91.03.00.4-0.7-0.50.7-1.3-1.1-0.71.3-1.30.5-1.3-0.51.7-1.0
Progressive ratio test 2 inactive lever presses0.91.02.80.3-0.3-0.60.3-1.2-1.0-0.11.1-1.40.3-1.4-0.91.7-1.4
Total sessions with >9 infusions1.61.74.01.1-1.5-0.5-0.2-1.8-1.8-0.81.7-1.60.4-1.6-0.62.0-0.9
Short access day 1 total inactive lever presses0.20.20.70.4-0.80.30.3-0.4-0.5-0.60.5-0.10.3-0.30.3-0.00.3
Short access day 10 total inactive lever presses1.51.62.8-1.01.00.1-1.61.51.40.2-1.51.7-0.91.71.5-1.41.0
Short access day 1 total infusions1.82.04.90.7-1.1-0.30.9-1.8-1.7-1.21.9-1.70.7-1.8-0.62.2-1.3
Short access day 10 total infusions1.92.14.11.3-1.8-0.50.5-2.0-2.0-1.22.0-1.60.6-1.7-0.42.0-0.6
Short access total infusions1.82.05.10.8-1.4-0.40.1-1.9-1.8-1.41.9-1.60.7-1.7-0.52.3-1.1
Short access day 1 locomotion2.32.44.11.2-1.60.70.6-1.9-1.9-0.61.9-2.01.3-1.9-2.01.6-1.2
Short access day 10 total locomotion0.10.10.60.3-0.3-0.2-0.8-0.4-0.4-0.10.4-0.4-0.2-0.3-0.10.3-0.1
Short access total locomotion1.21.23.4-0.5-0.30.2-0.6-1.2-1.1-1.41.2-1.11.0-1.2-0.61.7-1.8
Compulsive drug intake0.60.62.30.1-0.80.51.1-0.6-0.6-1.50.8-0.11.0-0.40.31.1-0.1
One hour access (0.3 mA shock)1.72.04.21.0-0.7-1.31.4-1.8-1.50.21.6-2.0-0.0-1.9-1.12.0-1.3
One hour access (shock baseline)0.70.82.20.8-0.3-0.90.4-1.1-0.90.80.8-1.5-0.2-1.2-1.20.9-0.9
Number of responses in last shaping day1.71.85.7-1.30.8-1.51.0-0.8-0.4-1.71.0-0.8-0.1-1.01.32.4-2.2
Context. condit. distance diff. score3.34.07.21.9-2.00.02.0-2.5-2.5-0.12.3-2.71.4-2.5-2.51.9-1.3
Locomotion velocity, session 11.21.32.10.9-1.41.30.4-1.3-1.5-0.81.4-1.21.2-1.3-1.10.8-0.6
Locomotion distance, session 10.81.02.30.5-0.5-0.00.4-1.2-1.10.11.1-1.50.6-1.4-1.51.1-1.2
Locomotion velocity, session 20.70.82.11.4-1.5-0.30.4-1.2-1.2-0.31.1-0.90.5-1.0-0.51.00.3
Locomotion distance, session 20.30.41.90.40.3-0.4-1.00.40.41.4-0.60.2-0.90.4-0.2-0.70.7
Locomotion velocity, session 30.80.93.51.4-1.90.40.7-0.9-1.2-1.01.0-0.31.0-0.5-0.30.61.0
Locomotion distance, session 32.42.66.82.0-2.61.01.5-1.8-2.1-1.21.9-1.31.7-1.5-1.31.10.3
Stereotopy head waving bouts, day 31.51.95.7-2.42.2-0.3-1.11.51.6-0.3-1.41.3-0.91.31.5-0.6-0.8
Stereotopy head waving duration, day 30.81.02.4-0.51.00.5-0.61.21.11.3-1.40.9-1.01.10.1-1.50.7
Locomotion velocity, session 70.30.41.6-0.10.20.31.3-0.3-0.20.30.3-0.70.5-0.6-1.20.3-0.8
Locomotion distance, session 70.60.82.70.20.2-0.51.6-0.7-0.50.60.6-1.20.3-1.0-1.40.8-1.1
Stereotopy head waving bouts, day 70.60.61.9-0.3-0.10.7-0.1-0.7-0.6-0.60.7-0.81.2-0.9-1.10.7-1.4
Stereotopy head waving duration, day 70.20.20.30.4-0.50.40.4-0.5-0.6-0.20.5-0.50.5-0.6-0.50.3-0.2
Locomotion velocity, session 83.64.410.13.2-3.01.32.2-2.3-2.50.62.1-2.31.2-2.2-2.70.70.4
Locomotion distance, session 81.21.84.51.7-1.3-0.21.1-1.6-1.60.81.3-1.90.5-1.6-2.11.0-0.5
Degree of sensitization distance1.61.66.2-1.52.5-2.00.30.81.41.4-1.00.1-1.70.30.50.2-1.2
Degree of sensitization stereotypy2.32.53.81.1-1.70.80.8-1.9-2.0-1.01.9-1.81.8-1.9-1.81.5-1.2
Condit. Reinf. active minus inactive responses0.70.83.70.10.0-1.00.50.60.6-0.2-0.51.0-0.90.81.9-0.21.4
Condit. Reinf. active-inactive response ratio0.80.83.0-0.20.5-1.00.30.90.90.0-0.81.2-1.01.01.7-0.31.2
Condit. Reinf. active responses0.40.52.6-0.10.3-0.60.30.70.7-0.1-0.61.0-0.80.81.6-0.31.0
Condit. Reinf. inactive responses0.00.00.20.2-0.30.20.3-0.1-0.2-0.30.2-0.0-0.1-0.00.40.10.1
Incentive salience index mean0.30.31.40.4-0.5-0.61.0-0.1-0.0-0.70.20.4-0.10.11.20.40.8
Condit. Reinf. lever presses0.50.61.60.9-1.30.50.9-0.8-0.9-0.60.9-0.61.0-0.7-0.60.40.2
Time in familiar zone, hab. session 10.00.00.00.0-0.10.20.0-0.2-0.2-0.00.2-0.20.2-0.2-0.2-0.0-0.2
Time in novel zone, hab. session 10.70.71.8-0.71.3-0.60.71.01.21.0-1.10.7-0.90.80.4-0.50.2
Total zone transitions, hab. session 10.71.03.20.10.11.1-1.31.10.80.7-1.11.1-0.51.20.1-1.81.4
Total locomotion distance, hab. session 12.53.69.9-3.12.7-1.2-1.61.92.2-1.2-1.62.1-1.01.82.70.1-0.7
Locomotion velocity, hab. session 12.02.97.9-2.82.1-1.0-1.71.51.7-1.8-1.21.9-0.61.62.70.4-0.6
Time in familiar zone, hab. session 20.40.41.81.0-0.3-0.40.0-0.0-0.11.4-0.2-0.2-0.7-0.0-0.4-0.70.9
Time in novel zone, hab. session 20.60.62.0-0.3-0.2-0.11.0-0.7-0.6-1.20.9-0.60.6-0.80.21.4-1.1
Total zone transitions, hab. session 20.60.82.40.5-0.10.7-0.60.80.60.9-0.90.9-0.71.00.3-1.51.6
Total locomotion distance, hab. session 21.92.57.0-2.12.1-1.3-1.11.71.9-0.5-1.51.8-1.31.72.7-0.10.1
Locomotion velocity, hab. session 22.53.39.1-2.12.2-1.4-1.32.02.2-0.3-1.82.2-1.72.03.0-0.60.6
Novel to familiar place preference ratio0.10.10.4-0.2-0.00.4-0.50.30.3-0.5-0.20.60.60.50.10.10.4
Novelty place preference0.10.10.2-0.0-0.10.3-0.30.20.2-0.3-0.20.50.40.30.20.10.5
Time in novel zone, NPP test0.10.10.30.2-0.20.3-0.00.20.10.0-0.20.30.30.2-0.10.00.5
Total zone transitions, NPP test0.20.31.10.8-0.71.00.2-0.2-0.30.40.1-0.20.2-0.1-0.7-0.60.5
Total locomotion distance, NPP test1.31.87.1-2.72.1-1.1-0.20.51.0-1.6-0.20.5-0.10.21.51.3-2.1
Locomotion velocity, NPP test1.62.39.4-3.12.3-1.1-0.60.71.2-1.8-0.40.7-0.10.41.71.3-2.2
Pavlov. Cond. lever latency0.81.03.1-0.71.2-0.7-1.81.01.01.1-1.20.7-1.30.90.5-0.70.2
Pavlov. Cond. magazine entry latency0.40.53.10.7-0.4-1.11.8-0.6-0.50.20.6-0.7-0.2-0.70.00.50.0
Pavlov. Cond. change in total contacts2.32.54.20.5-1.40.42.0-1.7-1.6-2.12.0-1.42.0-1.7-0.71.9-1.2
Pavlov. Cond. index score0.71.04.60.8-0.8-0.62.1-1.1-0.9-0.41.1-1.00.5-1.1-0.31.0-0.2
Pavlov. Cond. latency score0.70.94.80.7-0.9-0.32.2-1.0-0.9-0.71.2-0.90.7-1.1-0.21.0-0.3
Pavlov. Cond. lever contacts0.70.82.40.7-1.10.01.5-1.0-1.0-1.01.2-0.70.7-0.9-0.00.9-0.1
Pavlov. Cond. magazine entry number0.50.73.3-0.90.31.0-1.80.70.5-0.7-0.61.00.00.90.7-0.50.2
Pavlov. Cond. intertrial magazine entries0.30.41.3-0.80.20.9-1.10.20.2-1.1-0.00.50.50.30.50.2-0.4
Pavlov. Cond. lever-magazine prob. diff.0.70.93.40.8-0.9-0.41.8-1.0-0.9-0.51.2-1.00.7-1.1-0.40.9-0.3
Pavlov. Cond. response bias0.30.41.70.5-0.5-0.71.3-0.7-0.6-0.30.8-0.60.3-0.7-0.10.7-0.2
Bone: apparent density0.20.31.30.0-0.51.2-0.40.2-0.0-0.5-0.00.40.90.3-0.4-0.40.4
Bone surface0.81.53.51.7-1.9-0.10.8-1.5-1.6-0.31.5-1.31.0-1.3-1.11.00.3
Bone volume0.30.51.61.3-1.2-0.20.7-0.8-0.90.00.8-0.60.5-0.6-0.50.40.6
Bone: connectivity density1.11.74.90.8-1.71.50.0-1.3-1.5-1.51.5-0.92.2-1.1-1.50.9-0.4
Bone: cortical apparent density0.60.82.3-0.71.4-0.4-0.31.01.21.5-1.20.5-0.70.8-0.2-1.00.0
Bone: cortical area0.20.31.50.30.2-1.01.2-0.2-0.00.50.2-0.4-0.4-0.40.00.5-0.1
Bone: cortical porosity0.20.21.0-0.4-0.10.60.6-0.1-0.2-1.00.30.00.6-0.10.30.3-0.5
Bone: cortical porosity0.40.52.7-0.4-0.50.60.2-0.5-0.5-1.70.7-0.10.9-0.40.40.8-0.7
Bone: cortical thickness0.10.20.7-0.80.8-0.10.70.20.40.0-0.2-0.00.3-0.0-0.20.4-0.8
Bone: cortical thickness2.02.36.10.00.0-0.41.4-1.6-1.2-0.11.5-2.11.1-2.1-1.92.0-2.5
Bone: cortical tissue density0.60.72.0-0.71.3-0.3-0.41.01.11.4-1.10.5-0.70.8-0.2-1.00.1
Bone: elastic displacement0.30.31.1-0.91.00.6-0.20.60.70.4-0.70.3-0.00.4-0.2-0.4-0.6
Bone: elastic work0.20.31.3-0.10.11.1-1.10.30.10.3-0.30.10.30.2-0.5-0.6-0.1
Bone: endosteal estimation0.40.92.11.5-1.2-1.41.3-1.0-0.9-0.01.0-0.7-0.6-0.80.50.90.7
Bone: endosteal perimeter0.71.34.82.2-1.5-1.31.1-1.2-1.11.01.0-1.1-0.8-1.0-0.00.51.0
Bone: final force0.10.21.10.10.10.20.6-0.2-0.10.50.1-0.50.4-0.4-1.00.1-0.5
Bone: final moment0.10.21.10.10.10.10.5-0.3-0.20.50.2-0.60.4-0.5-1.00.2-0.5
Bone: marrow area0.30.71.71.3-1.0-1.31.1-0.8-0.80.00.8-0.6-0.6-0.70.50.80.7
Bone: maximum diameter0.40.72.21.5-0.8-1.11.3-0.6-0.60.90.4-0.6-0.9-0.50.20.20.8
Bone: maximum force0.20.41.50.9-0.80.70.7-0.6-0.70.30.5-0.60.7-0.5-1.2-0.00.1
Bone: maximum moment0.30.51.40.9-0.90.60.7-0.6-0.70.30.5-0.70.7-0.6-1.20.10.1
Bone: minimum diameter0.30.52.20.6-0.3-1.51.0-0.4-0.20.00.4-0.2-0.7-0.30.90.90.5
Bone: periosteal estimation0.61.23.31.4-1.1-1.41.8-1.2-1.10.21.2-1.2-0.4-1.20.11.20.2
Bone: periosteal perimeter0.61.03.71.6-0.5-1.20.70.10.01.9-0.3-0.1-1.40.20.2-0.71.7
Bone: post-yield work0.30.41.40.7-1.21.10.3-0.2-0.5-0.70.30.31.00.1-0.2-0.50.9
Bone: stiffness0.10.20.6-0.30.40.80.60.50.50.3-0.50.30.30.4-0.5-0.60.0
Bone: tissue strength1.00.94.8-1.10.32.2-0.70.80.5-1.0-0.60.91.20.8-0.3-1.0-0.3
Bone: trabecular number0.30.42.4-0.3-0.21.6-0.50.20.0-0.6-0.10.31.30.2-0.9-0.4-0.0
Bone: trabecular spacing0.70.92.10.1-0.1-0.61.1-1.1-0.8-0.31.1-1.30.2-1.3-0.41.4-1.5
Bone: trabecular thickness1.72.15.70.40.5-0.5-0.61.51.41.8-1.71.5-1.51.70.9-2.02.4
Bone: trabecular tissue density3.65.08.2-1.62.8-1.4-1.32.72.82.2-2.92.2-2.72.52.0-2.21.2
Breakpoint value in progressive ratio session0.20.20.50.1-0.30.70.4-0.4-0.4-0.20.4-0.50.5-0.5-0.7-0.1-0.5
Distance traveled before self-admin0.20.30.6-0.0-0.30.4-0.70.40.2-0.5-0.30.70.00.60.8-0.50.8
Distance traveled after self-admin1.41.54.6-0.2-0.51.1-2.11.00.6-1.0-0.81.70.21.51.4-1.31.7
Delta time in closed arm before/after self-admin3.93.814.50.91.2-1.9-0.81.51.63.8-2.00.8-3.31.40.6-2.12.2
Delta time in open arm before/after self-admin1.51.43.41.0-1.5-0.31.9-1.4-1.4-1.21.5-1.01.0-1.2-0.11.3-0.2
Diff in mean of infusions in LGA sessions2.63.05.4-1.82.00.8-1.22.32.30.7-2.22.1-0.72.21.1-2.20.7
Extinction: sum of active levers before priming0.10.10.60.40.1-0.40.50.10.10.8-0.2-0.1-0.4-0.0-0.1-0.20.3
Active lever presses in extinction session 60.90.82.00.1-0.5-0.20.4-1.1-1.0-0.71.1-1.30.6-1.2-0.81.0-1.4
Delta distance traveled before/after self-admin0.91.02.80.00.10.0-1.71.00.80.5-1.01.2-0.61.30.8-1.31.5
Delta ambulatory time before/after self-admin1.11.23.10.30.00.4-1.81.10.81.0-1.21.1-0.51.30.1-1.71.6
Time in closed arm before self-admin0.30.40.70.4-0.80.4-0.6-0.6-0.7-0.40.6-0.50.8-0.5-0.80.3-0.3
Time in closed arm after self-admin0.50.51.31.1-0.90.4-1.1-0.3-0.50.90.1-0.4-0.2-0.2-1.0-0.70.6
Time in open arm before self-admin1.01.03.4-1.51.9-0.0-0.61.21.40.8-1.20.8-0.80.90.4-0.7-0.5
Time in open arm after self-admin0.10.10.9-0.20.2-0.50.40.20.2-0.4-0.10.3-0.20.20.90.30.2
Sum of active levers in priming session hrs 5-60.70.71.3-0.81.1-0.2-0.61.01.00.6-1.00.8-0.80.90.7-1.10.2
Time to tail flick, vehicle, before self-admin0.50.51.3-0.71.1-0.2-0.30.91.00.8-1.00.6-0.60.70.3-0.60.1
Time to tail flick, vehicle, after self-admin1.01.03.71.9-1.3-0.4-0.1-1.0-1.11.30.7-1.2-0.3-0.9-1.40.10.6
Time to tail flick, test, before self-admin0.80.83.31.7-1.80.0-0.1-0.8-1.0-0.40.8-0.30.2-0.40.00.41.4
Time to tail flick, test, after self-admin0.70.72.91.1-0.2-1.70.7-0.7-0.51.30.4-1.0-0.9-0.8-0.40.60.1
Delta time to tail flick, vehicle, before/after SA1.71.74.21.6-1.50.40.6-1.6-1.60.41.4-1.80.7-1.6-2.00.6-0.6
Delta time to tail flick, test, before/after SA0.50.41.8-1.01.4-0.60.00.50.70.7-0.60.0-0.40.1-0.1-0.1-0.9
Ambulatory time before self-admin0.30.31.00.3-0.81.0-0.2-0.0-0.2-0.90.20.40.80.20.2-0.30.6
Ambulatory time after self-admin1.51.74.90.3-1.01.7-2.20.90.4-0.8-0.71.60.61.40.8-1.62.1
Total heroin consumption0.40.52.3-0.10.7-0.2-0.10.50.61.5-0.70.0-1.00.3-0.4-1.20.1
Area under the delay curve0.30.31.41.2-1.00.40.3-0.4-0.60.50.4-0.40.1-0.3-0.6-0.40.7
Delay disc. indifference point, 0s delay0.70.81.80.3-0.3-1.2-0.1-1.1-0.9-0.31.0-1.2-0.1-1.10.11.4-1.1
Delay disc. indifference point, 16s delay0.80.83.61.2-0.40.3-0.50.30.11.9-0.60.0-0.90.3-0.9-1.51.3
Delay disc. indifference point, 2s delay0.50.61.61.1-1.30.1-0.0-1.0-1.1-0.51.0-0.70.5-0.8-0.10.60.1
Delay disc. indifference point, 24s delay0.60.62.20.40.01.00.30.70.61.0-0.80.6-0.10.7-0.7-1.51.1
Delay disc. indifference point, 4s delay0.40.51.91.4-1.2-0.60.4-0.6-0.70.20.6-0.4-0.3-0.40.40.11.0
Delay disc. indifference point, 8s delay0.50.52.11.4-1.20.30.3-0.6-0.70.60.5-0.50.2-0.5-0.9-0.30.9
Delay discount exponential model param0.30.31.2-1.10.9-0.5-0.30.30.5-0.6-0.20.3-0.10.20.70.6-0.8
Delay discount hyperbolic model param0.30.41.4-1.21.1-0.3-0.40.60.7-0.3-0.50.5-0.20.50.60.2-0.6
Fecal boli incidents, locomotor time 16.87.312.51.9-2.5-0.71.9-3.5-3.3-1.43.5-3.52.1-3.5-2.63.3-2.3
Change in fecal boli incidents, locomotor task2.92.85.2-1.41.81.1-1.02.32.21.2-2.32.0-0.72.10.7-2.11.1
Time >=10cm from walls, locomotor time 11.31.33.31.3-1.81.00.8-1.2-1.4-0.81.3-0.91.4-1.0-1.10.70.2
Bouts of movement, locomotor time 11.41.56.11.7-0.9-0.5-1.40.40.11.6-0.60.5-1.70.70.5-1.62.5
Total resting periods, locomotor time 11.11.25.01.6-1.00.1-1.30.3-0.01.4-0.50.4-1.10.60.1-1.52.2
Rest time, locomotor task time 10.40.41.31.1-1.00.80.3-0.4-0.60.60.3-0.40.2-0.3-1.1-0.50.7
Distance moved, locomotor task time 10.40.42.0-0.40.7-1.40.70.10.30.0-0.10.1-0.90.11.20.5-0.3
Vertical activity count, locomotor time 10.30.31.7-0.30.7-1.30.10.30.50.5-0.40.1-0.90.20.80.3-0.1
Time >=10cm from walls, locomotor time 21.31.33.11.3-1.8-0.41.5-1.4-1.4-1.31.5-0.80.6-1.00.21.20.3
Bouts of movement, locomotor time 20.30.31.00.9-0.8-0.6-0.6-0.3-0.40.10.20.0-0.70.10.7-0.11.0
Total resting periods, locomotor time 20.20.20.70.8-0.8-0.6-0.6-0.4-0.5-0.00.3-0.1-0.4-0.10.50.00.7
Rest time, locomotor task time 20.40.42.7-1.00.50.6-1.60.20.2-0.7-0.10.20.60.10.1-0.1-0.8
Distance moved, locomotor task time 20.70.93.00.7-0.5-1.51.7-1.0-0.8-0.10.9-0.9-0.8-0.90.51.1-0.3
Vertical activity count, locomotor time 20.60.62.80.20.2-1.71.6-0.5-0.20.20.4-0.6-0.9-0.50.61.0-0.4
Weight adjusted by age0.40.42.0-0.50.5-0.91.4-0.20.0-0.60.4-0.20.1-0.40.51.1-0.7
Seeking ratio, delayed vs. immediate footshock0.30.32.0-0.6-0.10.2-0.1-0.3-0.3-1.40.50.00.3-0.20.90.6-0.7
Locomotion in novel chamber2.02.45.71.0-1.71.70.0-1.6-1.8-1.01.7-1.52.2-1.6-2.40.8-1.0
Locomotion in novel chamber post-restriction3.03.511.12.2-2.21.41.3-2.0-2.20.31.8-2.21.8-2.0-3.30.8-0.5
Progressive ratio1.01.24.42.1-2.00.30.5-1.2-1.40.21.0-0.90.2-0.9-0.70.21.0
Food seeking constrained by brief footshock0.81.04.71.0-0.1-2.20.6-0.10.11.1-0.1-0.0-1.80.11.30.31.1
Seeking ratio, punishment vs. effort0.91.13.4-1.51.5-1.7-0.00.60.9-0.6-0.50.7-0.80.51.80.8-0.6
Run reversals in cocaine runway, females1.61.63.70.30.5-1.90.30.91.00.9-1.01.2-1.91.21.9-0.41.9
Run reversals in cocaine runway, males0.90.93.61.6-0.70.3-0.2-0.5-0.61.90.1-0.9-0.3-0.5-1.8-0.60.5
Latency to leave start box in cocaine runway0.91.04.0-1.90.90.4-0.40.50.6-2.0-0.20.90.40.51.50.3-0.9
Latency to leave start box in cocaine runway, F0.91.03.9-1.70.8-0.6-0.2-0.10.2-2.00.40.10.3-0.21.31.2-1.6
Latency to leave start box in cocaine runway, M0.60.62.6-1.00.11.6-0.20.50.3-1.5-0.20.81.00.50.4-0.3-0.2
Cd content in liver0.30.41.4-0.91.2-0.40.10.60.70.4-0.60.3-0.80.40.5-0.1-0.5
Co content in liver0.70.81.90.8-0.2-1.01.1-1.0-0.80.80.8-1.4-0.6-1.2-0.61.0-0.7
Cu content in liver0.60.83.90.40.5-2.00.60.20.41.2-0.40.0-1.70.20.90.20.6
Fe content in liver1.11.32.5-0.1-0.4-0.21.5-1.2-1.0-1.01.3-1.31.3-1.4-1.01.5-1.6
K content in liver0.40.41.1-0.5-0.00.20.10.60.5-0.9-0.41.00.30.80.9-0.40.7
Mg content in liver0.30.31.20.7-1.0-0.21.0-0.1-0.3-0.60.20.30.10.20.6-0.01.1
Mn content in liver0.40.52.0-0.4-0.51.3-0.2-0.0-0.3-1.30.20.31.40.1-0.5-0.1-0.3
Na content in liver1.61.67.2-0.6-0.91.20.1-0.9-1.0-2.71.3-0.42.4-0.8-0.51.3-1.2
Rb content in liver0.70.83.31.1-0.2-0.6-0.00.50.41.8-0.70.4-1.00.5-0.1-1.11.7
Se content in liver0.81.06.0-1.3-0.01.2-0.80.20.1-2.40.20.81.40.40.50.4-0.6
Sr content in liver0.80.72.21.4-1.50.1-0.6-1.0-1.2-0.20.9-0.80.4-0.7-0.30.50.5
Zn content in liver0.70.83.80.8-0.2-1.22.0-0.8-0.60.80.7-1.1-0.3-1.0-0.31.0-0.4