Hub : Genes

Spryd3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000010793 0.27 0.1 0.0e+00 0.18 0.16 0.17 0.18 2.0e-19 1.2e-17 5.6e-19 3.0e-19
2 BLA gene expression ENSRNOG00000010793 0.38 0.11 8.2e-08 0.1 0.14 0.07 0.11 3.5e-06 5.7e-08 1.2e-04 1.7e-06
3 Brain gene expression ENSRNOG00000010793 0.24 0.11 9.5e-10 0.12 0.11 0.12 0.12 2.2e-11 1.1e-10 3.1e-11 2.0e-11
4 Brain mRNA stability ENSRNOG00000010793 0.26 0.1 1.8e-14 0.18 0.16 0.18 0.18 2.1e-16 1.2e-14 2.1e-16 3.8e-16
5 Eye gene expression ENSRNOG00000010793 0.42 0.19 7.3e-04 0.26 0.06 0.3 0.31 6.8e-05 4.4e-02 1.6e-05 1.0e-05
6 IL gene expression ENSRNOG00000010793 0.5 0.17 5.2e-07 0.26 0.23 0.24 0.24 5.0e-07 3.9e-06 1.6e-06 2.1e-06
7 IL mRNA stability ENSRNOG00000010793 0.4 0.16 4.0e-05 0.22 0.17 0.16 0.17 6.0e-06 6.7e-05 9.1e-05 7.0e-05
8 Liver gene expression ENSRNOG00000010793 0.11 0.05 3.3e-09 0.06 0.09 0.08 0.07 2.2e-07 8.0e-10 3.2e-09 1.8e-08
9 NAcc gene expression ENSRNOG00000010793 0.41 0.04 0.0e+00 0.24 0.31 0.3 0.3 1.2e-17 7.7e-24 2.2e-22 2.6e-22
10 NAcc mRNA stability ENSRNOG00000010793 0.09 0.06 6.4e-03 0.04 0.04 0.02 0.04 3.2e-04 9.6e-04 8.2e-03 6.4e-04
11 PL gene expression ENSRNOG00000010793 0.2 0.07 7.8e-10 0.14 0.12 0.09 0.14 1.1e-10 1.5e-09 4.6e-07 1.4e-10
12 PL mRNA stability ENSRNOG00000010793 0.17 0.09 2.7e-06 0.08 0.07 0.09 0.09 2.2e-06 3.8e-06 2.4e-07 2.6e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
BMI with tail1.34.27.7-2.8-1.3-1.9-1.8-1.7-2.0-2.71.5-1.6-2.2-2.2-2.2
BMI without tail0.20.30.8-0.60.2-0.6-0.60.4-0.7-0.60.4-0.5-0.5-0.7-0.9
Body weight0.41.63.4-1.8-0.4-1.2-1.1-0.9-1.3-1.80.5-0.8-1.5-1.4-1.5
Epididymis fat weight0.61.53.90.31.01.31.41.51.3-0.1-2.01.40.80.91.4
Glucose0.20.30.70.50.80.60.50.20.50.4-0.80.70.50.50.5
Heart weight0.20.20.6-0.30.50.50.7-0.30.8-0.3-0.50.6-0.00.30.6
Left kidney weight0.31.02.3-1.5-0.8-0.9-0.8-0.7-0.7-1.50.5-0.7-1.2-1.0-1.1
Right kidney weight1.13.03.8-2.0-1.7-1.9-1.8-1.5-1.7-1.91.1-1.5-2.0-1.8-1.8
Tail length0.20.71.31.21.10.60.61.10.51.1-0.70.60.80.70.5
Length with tail0.00.10.60.20.70.20.3-0.10.20.1-0.70.50.10.10.1
Length without tail0.20.41.7-1.1-0.4-0.2-0.2-1.3-0.2-1.2-0.1-0.1-0.7-0.5-0.3
Liver weight, left1.01.72.2-1.2-1.4-1.3-1.3-1.2-1.4-1.11.2-1.4-1.3-1.3-1.5
Liver weight, right0.61.02.7-1.5-1.2-0.5-0.5-0.4-0.7-1.70.9-1.0-1.0-0.9-0.7
Parametrial fat weight2.14.27.22.11.42.12.22.72.11.7-1.81.72.12.12.2
Retroperitoneal fat weight0.93.04.41.61.71.81.71.51.81.5-1.81.71.71.72.1
Intraocular pressure0.10.20.70.3-0.30.20.2-0.80.10.50.8-0.40.30.20.3
Extensor digitorum longus weight5.622.730.0-4.5-3.4-5.0-5.1-5.5-5.1-4.44.3-4.3-4.9-5.0-5.4
Soleus weight0.61.82.9-1.3-1.2-1.4-1.4-1.7-1.4-1.20.9-1.2-1.4-1.5-1.4
Tibialis anterior weight3.913.418.2-3.4-1.9-3.9-4.0-4.3-4.0-3.13.8-3.4-3.6-3.8-4.1
Tibia length0.82.15.6-2.2-1.1-1.1-1.1-1.0-1.0-2.41.3-1.3-1.6-1.4-1.3
Number of licking bursts0.40.51.81.30.30.10.11.00.11.30.20.10.70.60.1
Food consumed during 24 hour testing period0.30.41.9-0.8-0.7-0.3-0.30.3-0.1-1.40.4-0.6-0.7-0.6-0.4
Times rat made contact with spout0.40.40.9-0.2-1.0-0.7-0.70.3-0.7-0.60.6-0.8-0.6-0.6-0.7
Mean time between licks in bursts1.01.46.22.30.70.60.50.90.42.5-0.50.51.30.90.5
Mean num. licks in bursts0.50.62.4-1.3-0.7-0.4-0.4-0.8-0.4-1.50.0-0.4-0.9-0.8-0.4
Std. dev. time between licks in bursts0.91.03.91.70.40.40.31.60.42.0-0.70.60.90.80.3
Water consumed over 24 hours0.30.30.6-0.2-0.5-0.7-0.70.1-0.7-0.30.6-0.8-0.5-0.6-0.7
Indifference point 0 sec1.21.93.81.71.21.11.11.91.21.7-0.71.01.41.31.4
Indifference point AUC1.41.62.41.41.41.31.31.21.01.3-0.71.11.51.41.5
Indifference point function ln k3.24.57.1-2.3-2.0-2.1-2.1-1.5-2.0-2.31.5-2.0-2.4-2.3-2.7
Indifference point function log k3.24.57.1-2.3-2.0-2.1-2.1-1.5-2.0-2.31.5-2.0-2.4-2.3-2.7
Delay discounting total patch changes 0 sec1.42.25.21.81.31.21.22.31.41.7-0.91.11.51.51.5
Delay discounting total patch changes 12 sec3.04.06.22.02.02.22.11.82.11.8-1.11.72.22.12.5
Delay discounting total patch changes 18 sec3.54.67.02.61.82.01.92.41.82.6-1.21.72.42.22.4
Delay discounting total patch changes 24 sec0.60.72.10.90.40.70.71.40.60.90.10.31.00.81.2
Delay discounting total patch changes 6 sec1.52.35.42.31.41.11.01.31.12.3-0.81.11.81.61.8
Delay discounting time to switch 0 sec0.20.30.60.70.60.30.3-0.80.60.8-0.50.60.50.60.4
Delay discounting water rate 0 sec0.30.40.7-0.8-0.8-0.6-0.60.4-0.6-0.80.6-0.7-0.7-0.7-0.4
Delay discounting water rate 12 sec0.40.62.1-1.1-0.9-0.4-0.40.4-0.5-1.40.4-0.6-0.7-0.7-0.5
Delay discounting water rate 18 sec0.10.10.3-0.6-0.3-0.2-0.1-0.1-0.2-0.60.5-0.4-0.5-0.40.0
Delay discounting water rate 24 sec0.60.81.4-0.9-0.7-0.8-0.8-0.8-0.9-1.01.2-1.0-0.9-0.9-0.9
Delay discounting water rate 6 sec2.02.86.1-2.3-1.9-1.5-1.4-0.1-1.3-2.51.4-1.7-2.0-1.8-1.3
Locomotor activity0.00.00.20.40.10.10.00.10.10.3-0.10.10.20.20.1
Locomotor testing distance0.30.41.21.10.50.50.40.70.51.0-0.30.40.80.70.6
Locomotor testing rearing0.10.10.40.70.1-0.4-0.40.3-0.50.6-0.0-0.20.1-0.1-0.4
Light reinforcement 12.03.64.81.91.81.91.92.21.91.9-1.41.82.02.11.8
Light reinforcement 22.33.03.81.71.81.71.81.31.81.6-1.81.91.81.91.6
Reaction time number correct0.81.12.0-0.5-1.4-1.3-1.3-0.8-1.3-0.70.8-1.2-1.0-1.0-1.0
Reaction time mean minus median0.50.61.10.81.00.70.7-0.20.80.9-0.80.90.80.70.9
Reaction time mean minus median AUC0.40.51.30.90.90.50.5-0.60.61.1-0.50.70.80.70.6
Reaction time num false alarms3.24.45.51.72.32.42.32.32.31.5-1.82.12.12.12.2
Reaction time num false alarms AUC3.44.76.21.72.42.52.41.92.41.6-1.92.22.22.22.4
Reaction time trials correct on left0.81.12.0-0.5-1.4-1.3-1.3-0.8-1.3-0.70.8-1.2-1.0-1.0-1.0
Reaction time trials on left0.60.91.6-0.4-1.3-1.1-1.1-0.7-1.1-0.60.7-1.1-0.9-0.9-0.9
Reaction time mean0.10.10.3-0.30.50.20.2-0.40.1-0.2-0.10.2-0.00.00.3
Reaction time mean AUC0.10.10.5-0.40.3-0.2-0.1-0.7-0.2-0.30.0-0.0-0.3-0.3-0.0
Median of all reaction times0.10.10.5-0.70.1-0.1-0.0-0.4-0.3-0.70.2-0.2-0.4-0.4-0.0
Reaction time omissions2.43.35.01.22.12.02.01.31.91.1-2.22.11.51.62.1
Reaction time false alarm rate3.34.76.31.62.52.52.51.82.51.6-1.72.22.22.22.3
Reaction time premature initiation rate0.40.61.40.10.51.01.20.71.0-0.0-0.30.50.60.81.2
Reaction time premature initiations0.10.10.3-0.3-0.40.20.30.20.2-0.50.1-0.2-0.10.10.5
Std. dev. reaction times0.40.51.00.61.00.70.7-0.30.70.6-0.80.90.70.70.9
Reaction time trials completed0.60.91.6-0.4-1.3-1.1-1.1-0.7-1.1-0.60.7-1.1-0.9-0.9-0.9
Reaction time trials AUC0.81.21.9-0.7-1.4-1.3-1.3-0.7-1.3-0.80.9-1.2-1.1-1.1-1.1
Social response proportion1.21.32.90.40.81.51.50.41.40.2-1.31.21.01.11.7
Social responses2.53.24.21.91.91.61.61.61.61.9-2.11.91.71.71.9
Social time1.11.53.50.51.31.21.21.41.30.3-1.91.50.91.01.3
Conditioned locomotion0.70.92.60.31.61.00.91.20.90.5-0.60.80.80.80.8
Cocaine response after cond. corrected1.92.14.01.42.01.41.40.71.51.5-1.41.61.51.51.3
Cocaine response after cond. not corrected1.71.93.21.21.81.41.40.71.51.3-1.41.51.41.41.4
Cocaine response before conditioning0.10.10.5-0.3-0.7-0.0-0.0-0.0-0.0-0.30.3-0.3-0.2-0.10.2
Saline control response0.20.31.2-0.30.40.80.71.10.7-0.50.00.20.30.40.5
Condit. Reinf. active minus inactive responses0.60.82.7-1.0-0.8-0.7-0.7-1.6-0.7-0.70.9-0.7-0.7-0.7-0.8
Condit. Reinf. active-inactive response ratio0.70.82.2-1.1-0.8-0.7-0.7-1.5-0.7-0.90.7-0.7-0.8-0.7-0.8
Condit. Reinf. active responses0.60.81.9-1.0-0.9-0.8-0.8-1.4-0.8-0.41.2-0.9-0.6-0.7-0.8
Condit. Reinf. inactive responses0.10.10.70.50.20.10.10.50.10.80.10.10.40.30.2
Condit. Reinf. lever presses0.20.30.80.10.30.90.90.10.80.0-0.30.40.60.60.6
Condit. Reinf. lever reinforcers received0.20.21.0-0.5-0.5-0.3-0.3-1.0-0.3-0.00.7-0.5-0.2-0.2-0.3
Pavlov. Cond. lever latency1.01.42.5-0.8-0.7-1.5-1.6-0.9-1.5-0.70.9-1.0-1.3-1.3-1.3
Pavlov. Cond. magazine entry latency2.42.73.81.61.71.91.91.21.71.2-2.01.81.61.61.5
Pavlov. Cond. change in total contacts0.10.20.7-0.6-0.50.20.2-0.80.1-0.70.4-0.2-0.1-0.00.1
Pavlov. Cond. index score1.92.53.81.41.21.92.01.01.81.1-1.61.61.71.71.6
Pavlov. Cond. latency score1.82.33.51.41.21.81.91.01.71.0-1.61.51.61.61.6
Pavlov. Cond. lever contacts1.52.13.51.00.91.91.91.31.70.7-1.31.31.51.61.6
Pavlov. Cond. magazine entry number0.81.01.6-1.1-0.8-1.2-1.3-0.4-1.1-0.51.1-1.0-1.0-1.0-0.9
Pavlov. Cond. intertrial magazine entries0.00.10.3-0.30.1-0.2-0.20.6-0.10.00.2-0.2-0.1-0.1-0.1
Pavlov. Cond. lever-magazine prob. diff.1.31.72.81.21.01.61.70.71.40.8-1.41.31.41.41.3
Pavlov. Cond. response bias1.01.42.50.90.71.61.60.81.40.6-1.21.11.31.31.3
Conditioned reinforcement - actives0.50.51.91.20.40.30.4-1.40.41.30.10.20.60.60.1
Conditioned reinforcement - inactives1.31.42.90.41.01.61.60.21.70.2-1.01.31.11.31.5
Conditioned locomotion0.20.31.90.4-0.40.20.3-1.4-0.10.20.5-0.30.10.1-0.5
Intermittent access intake day 1-15 change0.30.30.8-0.4-0.9-0.3-0.4-0.7-0.5-0.50.6-0.7-0.4-0.4-0.6
Intermittent access intake escalation0.60.61.5-0.5-1.2-0.6-0.6-0.7-0.7-0.51.0-1.0-0.6-0.6-0.7
Intermittent access intake escalation 20.60.61.0-0.7-1.0-0.6-0.6-0.7-0.8-0.60.8-0.9-0.6-0.6-0.9
Intermitt. access day 1 inactive lever presses0.30.41.3-1.0-0.6-0.1-0.1-0.80.1-1.10.4-0.3-0.5-0.40.6
Intermitt. access day 15 inactive lever presses0.30.30.8-0.40.50.70.7-0.00.8-0.7-0.50.50.20.30.9
Intermitt. access escalation Index0.70.61.40.2-1.0-0.8-0.8-1.0-0.80.61.2-0.9-0.3-0.4-0.7
Intermittent access day 1 total infusions0.50.61.20.60.51.01.1-0.11.10.5-0.20.60.90.90.9
Intermittent access day 15 total infusions0.30.40.80.80.10.70.7-0.50.70.90.00.30.80.80.3
Intermittent access terminal intake (last 3 days)0.30.31.20.3-0.30.50.5-1.10.50.50.6-0.20.50.5-0.1
Intermittent access total infusions0.20.21.20.3-0.50.40.4-1.10.40.40.7-0.20.40.40.0
Intermittent access day 1 locomotion0.30.30.60.7-0.20.70.70.20.60.70.10.20.60.70.8
Intermittent access day 15 total locomotion0.30.31.2-0.5-1.1-0.1-0.1-0.6-0.3-0.60.5-0.6-0.4-0.4-0.5
Intermittent access total locomotion0.20.20.80.1-0.90.10.1-0.90.00.10.8-0.50.0-0.00.1
Intermittent access standard deviation0.30.30.60.50.60.70.70.20.50.5-0.80.60.60.60.3
Cocaine induced anxiety2.22.54.1-1.1-2.0-1.6-1.5-2.0-1.7-0.91.7-1.8-1.4-1.5-1.7
Post-drug Anxiety5.76.38.3-2.3-2.9-2.5-2.5-2.5-2.6-2.32.6-2.7-2.5-2.5-2.2
Baseline Anxiety0.30.31.6-1.00.10.20.10.50.3-1.3-0.10.1-0.3-0.20.4
Lifetime Intake0.20.20.60.3-0.60.40.4-0.80.40.30.7-0.30.30.30.2
Incentive Sensitization - Responses2.22.24.9-2.1-1.6-0.9-1.0-1.6-0.9-2.21.2-1.3-1.5-1.4-1.6
Incentive Sensitization - Breakpoint2.72.75.3-2.2-1.7-1.1-1.2-1.8-1.1-2.31.4-1.5-1.6-1.5-1.8
Progressive ratio test 1 active lever presses2.32.43.81.90.71.71.80.71.71.9-0.61.11.81.81.8
Progressive ratio test 1 breakpoint2.02.13.21.70.61.61.70.71.61.8-0.61.01.61.71.8
Progressive ratio test 1 inactive lever presses1.41.53.70.60.81.71.7-0.01.80.4-0.61.11.21.41.9
Progressive ratio test 2 active lever presses0.30.31.1-0.6-1.00.30.3-1.10.3-0.70.8-0.5-0.1-0.0-0.2
Progressive ratio test 2 breakpoint0.40.41.4-0.8-1.10.20.2-1.20.3-0.80.8-0.5-0.2-0.1-0.3
Progressive ratio test 2 inactive lever presses0.30.31.1-0.6-0.40.60.6-1.10.7-0.70.3-0.00.10.20.3
Total sessions with >9 infusions0.80.92.4-0.5-1.5-0.7-0.7-1.2-0.7-0.31.6-1.2-0.7-0.7-1.0
Short access day 1 total inactive lever presses0.20.31.4-0.4-0.60.60.6-1.20.4-0.70.3-0.10.00.10.1
Short access day 10 total inactive lever presses1.31.54.3-1.9-1.2-0.9-0.9-1.1-0.8-2.10.9-1.0-1.3-1.2-0.4
Short access day 1 total infusions0.10.10.3-0.2-0.10.40.4-0.10.6-0.2-0.10.20.10.30.5
Short access day 10 total infusions0.91.02.00.90.51.31.30.31.40.9-0.10.71.21.21.2
Short access total infusions0.10.10.20.2-0.40.20.3-0.10.40.30.5-0.20.20.20.4
Short access day 1 locomotion0.50.50.70.80.60.80.80.20.70.8-0.80.80.70.70.8
Short access day 10 total locomotion0.70.81.30.70.81.01.00.61.10.5-0.80.90.80.91.1
Short access total locomotion1.01.01.71.30.81.11.10.51.01.3-0.70.91.11.10.9
Compulsive drug intake2.32.33.6-1.9-1.7-1.2-1.2-0.9-1.2-1.81.8-1.5-1.6-1.4-1.7
One hour access (0.3 mA shock)3.44.06.2-2.1-2.1-1.6-1.6-2.5-1.7-1.92.3-2.0-1.9-1.8-2.2
One hour access (shock baseline)1.41.65.1-0.9-1.1-1.1-1.1-2.3-1.2-0.81.3-1.2-1.1-1.1-1.2
Number of responses in last shaping day3.63.65.21.52.22.12.10.72.11.3-2.32.21.81.92.0
Context. condit. distance diff. score0.91.12.3-1.2-1.0-0.6-0.6-0.4-0.8-1.51.4-1.3-1.0-1.0-1.0
Locomotion velocity, session 16.16.612.33.52.42.12.03.12.03.2-2.22.22.72.52.3
Locomotion distance, session 14.25.59.43.12.42.01.92.62.02.7-2.02.12.52.42.1
Locomotion velocity, session 22.93.46.52.51.81.21.12.61.22.4-2.11.71.81.71.2
Locomotion distance, session 24.56.48.32.92.62.42.32.62.42.7-2.32.42.72.62.5
Locomotion velocity, session 32.83.35.72.31.31.41.42.21.52.4-1.71.51.91.81.7
Locomotion distance, session 31.21.34.21.00.61.11.12.01.01.1-1.10.91.11.11.1
Stereotopy head waving bouts, day 30.70.81.4-0.4-0.7-1.1-1.1-0.9-1.1-0.21.2-1.0-0.7-0.8-0.9
Stereotopy head waving duration, day 30.20.20.50.3-0.2-0.7-0.7-0.5-0.70.40.5-0.5-0.2-0.3-0.5
Locomotion velocity, session 71.11.22.81.70.81.11.10.61.11.5-0.30.71.31.21.2
Locomotion distance, session 72.02.63.41.71.41.61.61.31.61.9-1.51.51.81.71.7
Stereotopy head waving bouts, day 70.50.51.0-0.3-0.5-0.8-0.8-0.9-0.8-0.61.0-0.8-0.7-0.7-0.6
Stereotopy head waving duration, day 71.41.72.5-0.7-1.3-1.4-1.3-1.6-1.3-1.01.6-1.4-1.2-1.3-1.2
Locomotion velocity, session 80.10.11.11.00.10.00.00.2-0.00.50.3-0.20.30.20.0
Locomotion distance, session 81.52.24.01.81.31.51.52.01.41.4-1.11.21.61.51.4
Degree of sensitization distance0.10.10.70.30.60.30.2-0.80.20.2-0.00.20.30.20.2
Degree of sensitization stereotypy1.01.11.7-0.6-1.2-1.0-1.0-1.2-1.0-1.11.3-1.1-1.0-1.0-0.9
Condit. Reinf. active minus inactive responses0.50.61.20.30.60.90.91.11.0-0.0-0.70.70.50.71.0
Condit. Reinf. active-inactive response ratio0.20.30.5-0.20.20.60.70.60.7-0.3-0.60.50.20.40.7
Condit. Reinf. active responses1.72.03.81.11.41.51.51.91.60.6-1.41.41.31.41.5
Condit. Reinf. inactive responses3.13.65.22.12.31.81.72.11.91.7-1.61.82.02.01.7
Incentive salience index mean0.30.41.20.30.30.70.71.10.8-0.1-0.50.50.40.60.7
Condit. Reinf. lever presses0.00.00.20.3-0.00.00.00.50.1-0.20.10.00.10.20.0
Time in familiar zone, hab. session 10.30.30.70.50.60.40.40.30.40.4-0.80.60.40.40.5
Time in novel zone, hab. session 10.50.51.2-0.7-0.6-0.5-0.5-0.7-0.5-0.71.1-0.8-0.6-0.6-0.7
Total zone transitions, hab. session 11.41.92.51.61.41.51.41.11.41.5-0.91.31.61.51.4
Total locomotion distance, hab. session 12.73.95.11.81.92.01.92.31.92.0-1.82.02.12.02.0
Locomotion velocity, hab. session 11.92.74.01.61.61.51.52.01.51.8-1.61.61.71.71.6
Time in familiar zone, hab. session 21.71.82.6-1.4-1.5-1.4-1.4-1.1-1.3-1.60.9-1.3-1.5-1.4-1.2
Time in novel zone, hab. session 20.30.30.80.70.90.60.60.50.40.9-0.10.40.60.60.3
Total zone transitions, hab. session 21.82.42.81.71.21.61.61.61.51.4-1.41.51.71.71.6
Total locomotion distance, hab. session 22.83.77.11.71.91.91.82.71.81.5-2.12.01.81.91.9
Locomotion velocity, hab. session 22.83.87.31.61.81.91.82.71.81.6-2.22.01.81.91.9
Novel to familiar place preference ratio0.10.20.7-0.90.1-0.3-0.20.0-0.2-0.60.2-0.1-0.5-0.4-0.3
Novelty place preference0.10.10.4-0.70.0-0.4-0.30.1-0.3-0.40.2-0.2-0.5-0.4-0.3
Time in novel zone, NPP test0.20.20.6-0.7-0.0-0.5-0.5-0.0-0.5-0.50.4-0.4-0.6-0.6-0.4
Total zone transitions, NPP test5.78.210.23.22.42.92.82.72.83.0-2.62.83.13.03.0
Total locomotion distance, NPP test7.610.514.33.42.93.13.13.83.13.0-3.43.33.23.33.2
Locomotion velocity, NPP test7.510.816.13.32.93.23.14.03.13.0-3.53.43.23.33.2
Pavlov. Cond. lever latency0.60.71.70.51.20.70.8-0.40.60.9-1.31.00.70.60.8
Pavlov. Cond. magazine entry latency1.62.13.3-1.2-1.6-1.3-1.3-1.6-1.1-1.81.7-1.4-1.4-1.4-1.3
Pavlov. Cond. change in total contacts2.22.43.5-1.4-1.9-1.5-1.5-1.2-1.4-1.81.8-1.6-1.5-1.4-1.4
Pavlov. Cond. index score2.53.24.8-1.4-2.2-1.7-1.7-1.2-1.6-2.22.1-1.9-1.8-1.7-1.7
Pavlov. Cond. latency score2.53.24.9-1.5-2.2-1.7-1.7-1.0-1.6-2.22.2-1.9-1.8-1.7-1.8
Pavlov. Cond. lever contacts1.11.32.8-0.6-1.7-1.1-1.2-0.0-1.1-1.21.5-1.3-1.1-1.0-1.1
Pavlov. Cond. magazine entry number1.11.43.51.01.50.90.91.10.81.9-1.31.11.21.10.9
Pavlov. Cond. intertrial magazine entries3.33.95.42.12.21.92.01.51.92.3-1.71.82.12.02.1
Pavlov. Cond. lever-magazine prob. diff.2.32.94.6-1.3-2.1-1.6-1.7-1.2-1.5-2.02.0-1.8-1.7-1.6-1.7
Pavlov. Cond. response bias1.11.32.4-0.7-1.5-1.1-1.1-1.0-1.0-1.31.3-1.2-1.1-1.1-0.9
Bone: apparent density1.93.15.8-2.1-1.6-1.6-1.6-1.2-1.7-2.41.2-1.6-2.0-1.9-1.8
Bone surface4.07.011.3-3.1-2.6-2.4-2.3-2.2-2.5-3.42.3-2.5-2.8-2.7-2.7
Bone volume3.45.79.0-2.8-2.2-2.2-2.1-1.8-2.3-3.02.1-2.3-2.6-2.5-2.5
Bone: connectivity density0.30.51.7-1.1-0.7-0.3-0.2-0.5-0.4-1.30.3-0.4-0.8-0.7-0.4
Bone: cortical apparent density1.31.74.71.22.21.31.30.61.21.4-1.01.41.31.21.0
Bone: cortical area1.62.47.5-2.7-1.5-1.0-1.0-1.1-1.0-2.51.1-1.2-1.6-1.4-1.2
Bone: cortical porosity0.10.10.5-0.40.10.20.20.70.2-0.4-0.20.0-0.00.00.2
Bone: cortical porosity0.20.31.1-0.30.30.50.61.10.6-0.2-0.50.40.30.40.5
Bone: cortical thickness0.10.21.4-1.2-0.20.10.2-0.60.1-1.0-0.10.0-0.3-0.2-0.0
Bone: cortical thickness3.13.66.00.91.92.12.21.42.20.9-2.42.31.71.92.1
Bone: cortical tissue density1.52.05.31.42.31.41.40.71.31.6-1.11.51.41.31.1
Bone: elastic displacement1.82.14.11.71.61.31.31.11.32.0-1.21.11.71.51.2
Bone: elastic work0.60.82.00.70.90.90.90.60.90.8-1.41.00.90.90.6
Bone: endosteal estimation3.88.212.6-3.4-3.0-2.8-2.8-1.6-2.7-3.52.6-2.8-3.1-3.0-2.8
Bone: endosteal perimeter3.36.811.0-3.3-2.7-2.5-2.4-1.8-2.4-3.22.1-2.4-2.8-2.7-2.7
Bone: final force3.35.48.7-2.9-2.6-2.2-2.1-1.7-2.1-3.01.5-2.0-2.5-2.4-2.2
Bone: final moment4.57.411.7-3.4-2.9-2.6-2.5-1.9-2.6-3.42.0-2.5-3.0-2.8-2.7
Bone: marrow area3.88.312.6-3.4-3.0-2.8-2.8-1.6-2.7-3.62.6-2.8-3.1-3.0-2.8
Bone: maximum diameter0.91.64.9-2.2-1.4-0.9-0.9-0.8-0.8-1.81.2-1.1-1.3-1.1-0.9
Bone: maximum force3.56.110.4-3.0-2.6-2.2-2.2-2.0-2.2-3.21.9-2.2-2.6-2.5-2.5
Bone: maximum moment4.78.113.3-3.5-2.9-2.6-2.6-2.1-2.6-3.62.3-2.7-3.0-2.9-2.9
Bone: minimum diameter2.95.412.1-3.5-2.2-1.9-1.8-1.6-1.9-3.41.8-2.0-2.5-2.3-2.0
Bone: periosteal estimation4.08.315.4-3.9-3.0-2.5-2.5-1.7-2.5-3.92.4-2.7-3.1-2.9-2.6
Bone: periosteal perimeter3.25.411.8-3.4-2.0-2.0-2.0-1.9-1.9-3.11.8-2.0-2.5-2.3-2.1
Bone: post-yield work2.83.86.4-2.4-2.1-1.7-1.8-1.3-1.7-2.51.7-1.8-2.1-2.0-2.0
Bone: stiffness5.18.112.6-3.2-3.2-2.7-2.7-2.2-2.7-3.52.3-2.6-3.1-2.9-2.7
Bone: tissue strength2.01.92.3-1.1-1.3-1.5-1.4-1.5-1.4-1.21.5-1.4-1.4-1.5-1.3
Bone: trabecular number0.30.41.0-0.8-0.7-0.5-0.5-0.1-0.6-1.00.2-0.5-0.8-0.7-0.5
Bone: trabecular spacing0.10.21.0-0.2-0.30.10.2-0.60.1-0.31.0-0.5-0.00.0-0.1
Bone: trabecular thickness0.10.10.4-0.20.60.20.20.40.3-0.0-0.60.50.10.10.3
Bone: trabecular tissue density0.10.20.50.10.50.60.60.20.70.2-0.20.60.40.50.1
Breakpoint value in progressive ratio session3.84.26.1-2.4-2.5-1.6-1.4-1.8-1.7-2.22.3-2.2-2.0-1.9-2.4
Distance traveled before self-admin0.10.10.5-0.0-0.20.00.1-0.7-0.0-0.00.3-0.20.10.10.2
Distance traveled after self-admin0.50.61.9-1.1-1.20.20.2-1.00.4-1.40.6-0.5-0.4-0.20.2
Delta time in closed arm before/after self-admin0.50.51.4-1.2-0.7-0.5-0.4-0.1-0.4-1.20.9-0.7-0.8-0.7-0.2
Delta time in open arm before/after self-admin3.93.75.62.02.21.81.81.52.01.7-2.42.11.91.91.5
Diff in mean of infusions in LGA sessions0.10.20.7-0.60.4-0.10.0-0.5-0.2-0.8-0.20.1-0.4-0.3-0.4
Extinction: sum of active levers before priming3.63.64.9-1.9-1.9-2.1-1.9-0.8-2.1-1.71.7-1.9-2.1-2.0-2.2
Active lever presses in extinction session 60.90.92.9-1.0-0.8-0.8-0.7-0.6-1.0-0.80.8-0.9-0.9-0.9-1.7
Delta distance traveled before/after self-admin0.40.41.8-0.9-0.40.60.50.90.9-1.3-0.30.1-0.10.10.6
Delta ambulatory time before/after self-admin0.50.62.8-1.2-0.50.60.60.60.9-1.7-0.0-0.0-0.20.10.6
Time in closed arm before self-admin0.10.20.60.60.6-0.1-0.20.4-0.10.8-0.40.30.20.20.1
Time in closed arm after self-admin0.40.41.2-0.4-0.5-0.6-0.7-0.6-0.6-0.31.1-0.7-0.5-0.6-0.2
Time in open arm before self-admin1.41.53.3-1.1-1.4-0.8-0.8-1.8-1.0-1.11.6-1.3-1.0-1.0-1.4
Time in open arm after self-admin0.90.92.10.81.21.01.00.61.10.6-1.41.30.80.90.4
Sum of active levers in priming session hrs 5-60.10.10.5-0.1-0.30.40.6-0.70.4-0.10.4-0.00.20.3-0.3
Time to tail flick, vehicle, before self-admin0.10.20.70.50.80.20.3-0.20.10.4-0.40.50.40.3-0.0
Time to tail flick, vehicle, after self-admin0.60.71.2-0.8-0.5-0.9-0.9-0.4-1.1-1.10.2-0.6-1.0-1.0-0.8
Time to tail flick, test, before self-admin2.52.55.21.22.31.71.60.71.60.9-1.81.91.61.61.6
Time to tail flick, test, after self-admin1.41.53.1-1.6-0.6-1.1-1.1-1.0-1.2-1.80.9-1.0-1.5-1.4-0.9
Delta time to tail flick, vehicle, before/after SA1.41.42.4-1.3-1.6-1.1-1.1-0.4-1.1-1.30.9-1.2-1.3-1.2-1.0
Delta time to tail flick, test, before/after SA4.03.54.9-2.2-1.9-1.9-1.8-1.1-1.9-2.21.8-1.9-2.2-2.1-1.5
Ambulatory time before self-admin0.10.10.30.1-0.3-0.00.0-0.6-0.10.20.4-0.30.20.10.1
Ambulatory time after self-admin0.91.03.3-1.5-1.5-0.2-0.2-1.10.1-1.81.0-0.9-0.8-0.6-0.1
Total heroin consumption3.34.06.6-2.5-2.3-1.6-1.4-1.4-1.6-2.61.9-2.0-2.0-1.9-2.3
Area under the delay curve0.40.51.3-0.9-0.4-0.5-0.5-1.1-0.5-0.90.4-0.5-0.6-0.6-0.7
Delay disc. indifference point, 0s delay0.10.10.70.30.80.10.3-0.40.00.2-0.50.40.30.10.0
Delay disc. indifference point, 16s delay0.30.31.1-1.0-0.2-0.2-0.1-0.8-0.2-1.00.4-0.4-0.5-0.5-0.3
Delay disc. indifference point, 2s delay2.02.34.7-1.2-1.3-1.5-1.6-2.2-1.5-0.91.6-1.4-1.4-1.4-1.8
Delay disc. indifference point, 24s delay0.30.30.8-0.7-0.0-0.5-0.5-0.9-0.3-0.80.4-0.4-0.7-0.6-0.6
Delay disc. indifference point, 4s delay0.70.81.5-1.0-1.0-0.7-0.6-1.2-0.7-1.00.8-0.9-0.8-0.8-0.9
Delay disc. indifference point, 8s delay0.20.20.4-0.7-0.5-0.3-0.4-0.5-0.3-0.60.3-0.4-0.4-0.4-0.6
Delay discount exponential model param0.80.82.01.10.70.80.81.40.71.0-0.60.70.90.81.0
Delay discount hyperbolic model param1.01.02.51.20.90.90.91.60.81.1-0.80.91.00.91.1
Fecal boli incidents, locomotor time 12.12.23.21.31.11.61.61.71.81.5-1.51.41.51.51.3
Change in fecal boli incidents, locomotor task0.80.81.3-0.5-0.7-1.1-1.0-0.8-1.1-0.70.9-0.9-0.9-1.0-0.8
Time >=10cm from walls, locomotor time 10.30.30.70.30.40.70.60.90.80.1-0.40.50.70.60.4
Bouts of movement, locomotor time 11.51.62.51.30.71.61.61.01.41.0-1.21.31.51.41.2
Total resting periods, locomotor time 12.42.73.31.81.11.81.81.61.61.4-1.61.61.81.71.6
Rest time, locomotor task time 10.40.41.41.20.40.50.40.60.41.1-0.40.40.70.60.4
Distance moved, locomotor task time 10.30.41.0-0.9-0.1-0.6-0.5-0.6-0.5-0.61.0-0.7-0.6-0.6-0.3
Vertical activity count, locomotor time 10.50.52.3-0.9-0.4-0.4-0.2-1.5-0.4-0.80.7-0.4-0.5-0.5-0.7
Time >=10cm from walls, locomotor time 20.10.10.20.2-0.40.40.40.30.30.1-0.10.10.40.4-0.1
Bouts of movement, locomotor time 21.01.12.1-0.9-1.5-0.9-0.9-1.2-1.1-0.81.2-1.1-0.8-0.9-1.1
Total resting periods, locomotor time 20.80.81.5-0.8-1.2-0.7-0.8-1.2-0.9-0.81.1-0.9-0.6-0.7-1.0
Rest time, locomotor task time 21.01.22.51.61.31.00.80.90.81.6-0.80.91.10.90.9
Distance moved, locomotor task time 20.00.10.2-0.50.0-0.1-0.1-0.1-0.2-0.50.0-0.1-0.1-0.10.1
Vertical activity count, locomotor time 20.30.41.1-0.5-0.8-0.6-0.5-1.1-0.7-0.50.3-0.4-0.5-0.4-0.7
Weight adjusted by age0.91.03.10.91.80.70.70.60.70.8-1.41.30.70.70.8
Seeking ratio, delayed vs. immediate footshock0.20.20.5-0.00.70.70.70.00.6-0.2-0.40.50.40.40.0
Locomotion in novel chamber2.12.64.4-1.7-1.2-1.5-1.7-1.7-1.6-1.81.4-1.4-1.5-1.5-2.1
Locomotion in novel chamber post-restriction0.80.91.7-0.9-1.2-1.1-0.9-1.0-0.7-0.91.3-1.1-0.8-0.8-0.9
Progressive ratio0.10.10.3-0.1-0.1-0.1-0.1-0.5-0.3-0.10.4-0.3-0.1-0.2-0.6
Food seeking constrained by brief footshock0.30.41.1-0.2-0.60.91.00.51.0-0.20.30.10.50.80.5
Seeking ratio, punishment vs. effort0.10.20.5-0.2-0.30.40.60.50.7-0.2-0.20.30.30.50.6
Run reversals in cocaine runway, females0.30.31.3-1.0-0.5-0.3-0.3-0.4-0.5-1.20.1-0.3-0.6-0.5-0.4
Run reversals in cocaine runway, males0.40.41.60.91.20.00.0-0.20.21.0-0.90.80.30.30.2
Latency to leave start box in cocaine runway0.00.00.1-0.10.30.00.0-0.00.00.10.2-0.0-0.00.0-0.0
Latency to leave start box in cocaine runway, F0.91.01.91.21.30.80.90.71.01.4-0.71.00.90.90.8
Latency to leave start box in cocaine runway, M2.01.93.6-1.9-1.5-1.1-1.1-1.2-1.0-1.91.5-1.4-1.4-1.3-1.1
Cd content in liver0.10.10.20.4-0.10.40.4-0.40.40.2-0.00.10.30.30.5
Co content in liver1.31.62.1-0.7-1.4-1.3-1.3-0.8-1.3-1.11.4-1.5-1.2-1.3-1.3
Cu content in liver9.411.319.1-3.2-4.4-3.1-3.0-3.0-3.1-3.33.7-3.7-3.3-3.1-3.2
Fe content in liver0.30.41.20.90.40.40.40.40.31.1-0.40.40.70.60.6
K content in liver0.30.30.70.4-0.8-0.8-0.80.4-0.80.50.3-0.6-0.3-0.3-0.7
Mg content in liver0.20.30.60.6-0.8-0.5-0.50.6-0.60.70.4-0.5-0.0-0.1-0.4
Mn content in liver0.10.10.20.50.2-0.3-0.30.1-0.30.3-0.20.10.10.0-0.1
Na content in liver0.20.30.50.3-0.7-0.5-0.5-0.3-0.60.60.5-0.5-0.1-0.2-0.6
Rb content in liver1.72.15.0-1.1-2.0-1.2-1.2-0.8-1.3-1.22.2-2.0-1.2-1.2-1.3
Se content in liver1.31.63.01.21.41.21.20.51.21.7-1.21.31.31.31.2
Sr content in liver0.20.11.3-0.10.10.20.31.10.2-0.0-0.40.20.10.10.1
Zn content in liver1.41.64.00.80.61.41.52.01.40.8-0.91.01.21.41.3