Hub : Genes

Cd180

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression ENSRNOG00000010266 0.11 0.1 4e-06 0.07 0.05 0.07 0.04 2.8e-07 9.7e-06 1e-06 7.4e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1
BMI with tail2.16.76.72.6
BMI without tail0.91.91.91.4
Body weight0.73.03.0-1.7
Epididymis fat weight0.00.10.1-0.3
Glucose0.30.40.40.7
Heart weight1.11.61.61.3
Left kidney weight0.51.31.3-1.2
Right kidney weight0.20.40.4-0.7
Tail length5.817.517.5-4.2
Length with tail8.932.732.7-5.7
Length without tail5.411.711.7-3.4
Liver weight, left2.33.73.7-1.9
Liver weight, right0.20.30.3-0.5
Parametrial fat weight0.00.10.1-0.3
Retroperitoneal fat weight0.10.50.50.7
Intraocular pressure4.05.65.62.4
Extensor digitorum longus weight3.614.614.63.8
Soleus weight0.10.20.20.5
Tibialis anterior weight2.58.88.83.0
Tibia length5.314.814.8-3.8
Number of licking bursts4.65.45.42.3
Food consumed during 24 hour testing period1.51.81.8-1.4
Times rat made contact with spout0.40.50.50.7
Mean time between licks in bursts0.10.10.10.3
Mean num. licks in bursts3.23.83.8-2.0
Std. dev. time between licks in bursts0.81.01.01.0
Water consumed over 24 hours1.11.31.31.2
Indifference point 0 sec2.13.33.3-1.8
Indifference point AUC0.30.30.30.6
Indifference point function ln k1.01.41.4-1.2
Indifference point function log k1.01.41.4-1.2
Delay discounting total patch changes 0 sec2.84.64.6-2.1
Delay discounting total patch changes 12 sec0.00.00.00.0
Delay discounting total patch changes 18 sec0.00.00.0-0.1
Delay discounting total patch changes 24 sec0.40.50.5-0.7
Delay discounting total patch changes 6 sec0.71.01.0-1.0
Delay discounting time to switch 0 sec4.16.26.22.5
Delay discounting water rate 0 sec2.54.04.0-2.0
Delay discounting water rate 12 sec2.63.83.8-2.0
Delay discounting water rate 18 sec4.05.35.3-2.3
Delay discounting water rate 24 sec2.12.82.8-1.7
Delay discounting water rate 6 sec11.416.516.5-4.1
Locomotor activity0.10.10.10.3
Locomotor testing distance0.91.61.61.3
Locomotor testing rearing0.20.30.30.5
Light reinforcement 11.22.12.1-1.5
Light reinforcement 21.11.51.51.2
Reaction time number correct11.216.116.1-4.0
Reaction time mean minus median0.10.20.2-0.4
Reaction time mean minus median AUC0.20.20.2-0.5
Reaction time num false alarms0.71.01.01.0
Reaction time num false alarms AUC1.31.81.81.3
Reaction time trials correct on left11.216.116.1-4.0
Reaction time trials on left11.916.816.8-4.1
Reaction time mean1.01.31.31.1
Reaction time mean AUC0.60.80.80.9
Median of all reaction times1.72.32.31.5
Reaction time omissions1.82.42.4-1.6
Reaction time false alarm rate7.210.310.33.2
Reaction time premature initiation rate1.01.31.3-1.1
Reaction time premature initiations7.010.010.0-3.2
Std. dev. reaction times0.00.00.00.0
Reaction time trials completed11.916.816.8-4.1
Reaction time trials AUC10.715.215.2-3.9
Social response proportion0.20.20.20.4
Social responses0.70.90.9-0.9
Social time0.40.50.5-0.7
Conditioned locomotion0.50.60.60.8
Cocaine response after cond. corrected1.71.91.9-1.4
Cocaine response after cond. not corrected2.73.03.0-1.7
Cocaine response before conditioning0.30.30.3-0.6
Saline control response0.70.90.9-0.9
Condit. Reinf. active minus inactive responses3.94.84.8-2.2
Condit. Reinf. active-inactive response ratio1.92.02.0-1.4
Condit. Reinf. active responses1.41.91.9-1.4
Condit. Reinf. inactive responses0.10.10.1-0.3
Condit. Reinf. lever presses2.23.13.1-1.8
Condit. Reinf. lever reinforcers received1.82.52.5-1.6
Pavlov. Cond. lever latency0.71.01.01.0
Pavlov. Cond. magazine entry latency0.20.20.2-0.4
Pavlov. Cond. change in total contacts2.53.53.5-1.9
Pavlov. Cond. index score1.11.41.4-1.2
Pavlov. Cond. latency score1.31.71.7-1.3
Pavlov. Cond. lever contacts0.81.11.1-1.0
Pavlov. Cond. magazine entry number0.40.50.50.7
Pavlov. Cond. intertrial magazine entries1.92.42.4-1.6
Pavlov. Cond. lever-magazine prob. diff.1.01.31.3-1.1
Pavlov. Cond. response bias0.30.50.5-0.7
Conditioned reinforcement - actives0.40.40.4-0.6
Conditioned reinforcement - inactives1.11.31.3-1.1
Conditioned locomotion1.11.31.3-1.2
Intermittent access intake day 1-15 change0.30.30.3-0.6
Intermittent access intake escalation0.90.90.9-0.9
Intermittent access intake escalation 20.10.10.1-0.3
Intermitt. access day 1 inactive lever presses1.92.12.11.4
Intermitt. access day 15 inactive lever presses1.11.21.21.1
Intermitt. access escalation Index0.00.00.0-0.2
Intermittent access day 1 total infusions1.11.21.2-1.1
Intermittent access day 15 total infusions2.73.13.1-1.7
Intermittent access terminal intake (last 3 days)1.51.71.7-1.3
Intermittent access total infusions3.23.63.6-1.9
Intermittent access day 1 locomotion3.03.03.0-1.7
Intermittent access day 15 total locomotion4.64.94.9-2.2
Intermittent access total locomotion5.86.56.5-2.5
Intermittent access standard deviation0.10.10.10.3
Cocaine induced anxiety1.01.11.1-1.1
Post-drug Anxiety1.41.51.5-1.2
Baseline Anxiety0.00.00.00.2
Lifetime Intake3.43.83.8-1.9
Incentive Sensitization - Responses0.20.20.2-0.4
Incentive Sensitization - Breakpoint0.10.10.1-0.3
Progressive ratio test 1 active lever presses1.31.31.3-1.1
Progressive ratio test 1 breakpoint1.11.21.2-1.1
Progressive ratio test 1 inactive lever presses1.31.41.4-1.2
Progressive ratio test 2 active lever presses0.40.40.4-0.6
Progressive ratio test 2 breakpoint0.30.30.3-0.5
Progressive ratio test 2 inactive lever presses0.70.80.8-0.9
Total sessions with >9 infusions0.50.50.5-0.7
Short access day 1 total inactive lever presses0.40.40.4-0.7
Short access day 10 total inactive lever presses0.30.30.30.5
Short access day 1 total infusions2.42.62.6-1.6
Short access day 10 total infusions2.02.32.3-1.5
Short access total infusions2.42.72.7-1.6
Short access day 1 locomotion0.10.10.1-0.4
Short access day 10 total locomotion0.10.10.1-0.3
Short access total locomotion2.02.02.0-1.4
Compulsive drug intake0.80.80.80.9
One hour access (0.3 mA shock)1.92.22.2-1.5
One hour access (shock baseline)4.65.35.3-2.3
Number of responses in last shaping day0.40.40.40.6
Context. condit. distance diff. score1.21.51.5-1.2
Locomotion velocity, session 10.20.20.2-0.4
Locomotion distance, session 10.20.30.3-0.6
Locomotion velocity, session 22.32.72.7-1.6
Locomotion distance, session 20.10.20.2-0.4
Locomotion velocity, session 33.23.83.8-1.9
Locomotion distance, session 33.94.24.2-2.1
Stereotopy head waving bouts, day 30.40.40.4-0.7
Stereotopy head waving duration, day 30.00.00.00.1
Locomotion velocity, session 70.60.60.6-0.8
Locomotion distance, session 70.70.90.9-0.9
Stereotopy head waving bouts, day 71.41.61.61.3
Stereotopy head waving duration, day 70.30.30.30.6
Locomotion velocity, session 82.63.13.1-1.8
Locomotion distance, session 82.23.33.3-1.8
Degree of sensitization distance0.70.70.70.8
Degree of sensitization stereotypy1.31.41.41.2
Condit. Reinf. active minus inactive responses3.03.43.41.8
Condit. Reinf. active-inactive response ratio3.84.14.12.0
Condit. Reinf. active responses0.40.50.50.7
Condit. Reinf. inactive responses1.82.12.1-1.5
Incentive salience index mean2.63.13.11.8
Condit. Reinf. lever presses0.60.70.70.9
Time in familiar zone, hab. session 12.72.52.5-1.6
Time in novel zone, hab. session 12.32.22.21.5
Total zone transitions, hab. session 10.20.20.20.5
Total locomotion distance, hab. session 10.30.40.40.6
Locomotion velocity, hab. session 10.20.30.30.6
Time in familiar zone, hab. session 21.21.21.2-1.1
Time in novel zone, hab. session 21.71.71.71.3
Total zone transitions, hab. session 20.10.10.1-0.3
Total locomotion distance, hab. session 20.30.40.40.6
Locomotion velocity, hab. session 20.00.10.10.3
Novel to familiar place preference ratio1.41.51.51.2
Novelty place preference0.80.90.90.9
Time in novel zone, NPP test0.80.90.90.9
Total zone transitions, NPP test1.21.71.7-1.3
Total locomotion distance, NPP test0.00.00.0-0.0
Locomotion velocity, NPP test0.30.40.4-0.6
Pavlov. Cond. lever latency0.00.00.0-0.2
Pavlov. Cond. magazine entry latency2.93.73.7-1.9
Pavlov. Cond. change in total contacts2.02.12.1-1.5
Pavlov. Cond. index score0.20.30.3-0.6
Pavlov. Cond. latency score0.00.00.0-0.2
Pavlov. Cond. lever contacts0.10.10.1-0.4
Pavlov. Cond. magazine entry number1.72.22.21.5
Pavlov. Cond. intertrial magazine entries3.03.63.61.9
Pavlov. Cond. lever-magazine prob. diff.0.50.60.6-0.8
Pavlov. Cond. response bias1.82.32.3-1.5
Bone: apparent density0.60.90.91.0
Bone surface0.40.70.70.8
Bone volume0.61.01.01.0
Bone: connectivity density0.00.00.0-0.0
Bone: cortical apparent density1.31.71.7-1.3
Bone: cortical area0.20.30.3-0.6
Bone: cortical porosity2.22.32.31.5
Bone: cortical porosity1.81.91.91.4
Bone: cortical thickness0.71.11.1-1.0
Bone: cortical thickness1.72.02.0-1.4
Bone: cortical tissue density1.31.71.7-1.3
Bone: elastic displacement0.10.10.10.3
Bone: elastic work0.30.30.30.6
Bone: endosteal estimation0.00.10.10.3
Bone: endosteal perimeter0.20.40.40.6
Bone: final force0.10.10.1-0.3
Bone: final moment0.10.20.2-0.4
Bone: marrow area0.00.10.10.3
Bone: maximum diameter0.40.70.70.8
Bone: maximum force0.00.10.10.3
Bone: maximum moment0.00.00.00.2
Bone: minimum diameter1.63.03.0-1.7
Bone: periosteal estimation0.00.00.0-0.2
Bone: periosteal perimeter0.00.00.00.1
Bone: post-yield work0.10.20.20.4
Bone: stiffness0.10.10.10.3
Bone: tissue strength2.01.91.91.4
Bone: trabecular number0.00.00.00.2
Bone: trabecular spacing0.20.20.2-0.5
Bone: trabecular thickness1.31.51.51.2
Bone: trabecular tissue density2.63.63.61.9
Breakpoint value in progressive ratio session1.82.02.01.4
Distance traveled before self-admin1.01.11.1-1.0
Distance traveled after self-admin1.31.51.5-1.2
Delta time in closed arm before/after self-admin8.48.28.22.9
Delta time in open arm before/after self-admin0.40.40.4-0.6
Diff in mean of infusions in LGA sessions0.00.00.0-0.0
Extinction: sum of active levers before priming1.01.11.11.0
Active lever presses in extinction session 60.60.50.50.7
Delta distance traveled before/after self-admin0.50.50.5-0.7
Delta ambulatory time before/after self-admin0.91.01.0-1.0
Time in closed arm before self-admin1.11.21.2-1.1
Time in closed arm after self-admin0.60.60.60.8
Time in open arm before self-admin0.30.30.30.6
Time in open arm after self-admin0.10.20.20.4
Sum of active levers in priming session hrs 5-60.00.00.00.2
Time to tail flick, vehicle, before self-admin5.95.95.9-2.4
Time to tail flick, vehicle, after self-admin0.10.10.1-0.3
Time to tail flick, test, before self-admin0.70.70.7-0.8
Time to tail flick, test, after self-admin0.00.00.00.1
Delta time to tail flick, vehicle, before/after SA3.73.63.61.9
Delta time to tail flick, test, before/after SA0.20.20.20.4
Ambulatory time before self-admin0.20.20.2-0.4
Ambulatory time after self-admin1.21.31.3-1.1
Total heroin consumption0.20.20.20.5
Area under the delay curve0.50.50.5-0.7
Delay disc. indifference point, 0s delay0.00.00.0-0.1
Delay disc. indifference point, 16s delay0.20.20.2-0.4
Delay disc. indifference point, 2s delay0.50.60.6-0.8
Delay disc. indifference point, 24s delay0.00.00.00.1
Delay disc. indifference point, 4s delay0.50.50.5-0.7
Delay disc. indifference point, 8s delay0.20.20.2-0.4
Delay discount exponential model param0.60.60.60.8
Delay discount hyperbolic model param0.80.90.90.9
Fecal boli incidents, locomotor time 11.61.81.81.3
Change in fecal boli incidents, locomotor task0.10.10.10.2
Time >=10cm from walls, locomotor time 13.23.23.21.8
Bouts of movement, locomotor time 10.20.20.20.4
Total resting periods, locomotor time 10.10.10.10.4
Rest time, locomotor task time 12.22.42.41.6
Distance moved, locomotor task time 10.50.60.6-0.8
Vertical activity count, locomotor time 11.31.41.4-1.2
Time >=10cm from walls, locomotor time 22.52.72.71.6
Bouts of movement, locomotor time 20.00.00.0-0.1
Total resting periods, locomotor time 20.10.10.10.3
Rest time, locomotor task time 22.73.13.11.8
Distance moved, locomotor task time 20.91.11.1-1.0
Vertical activity count, locomotor time 21.01.11.1-1.1
Weight adjusted by age1.31.41.4-1.2
Seeking ratio, delayed vs. immediate footshock3.43.93.92.0
Locomotion in novel chamber3.44.24.22.1
Locomotion in novel chamber post-restriction0.10.10.10.3
Progressive ratio0.00.00.00.0
Food seeking constrained by brief footshock2.63.23.2-1.8
Seeking ratio, punishment vs. effort1.01.21.2-1.1
Run reversals in cocaine runway, females0.00.00.00.2
Run reversals in cocaine runway, males0.30.30.30.5
Latency to leave start box in cocaine runway1.82.02.01.4
Latency to leave start box in cocaine runway, F0.50.60.60.8
Latency to leave start box in cocaine runway, M1.81.81.81.3
Cd content in liver0.50.50.5-0.7
Co content in liver0.10.10.1-0.3
Cu content in liver0.20.20.2-0.4
Fe content in liver2.73.23.2-1.8
K content in liver0.60.60.6-0.8
Mg content in liver0.00.00.0-0.1
Mn content in liver0.00.00.0-0.0
Na content in liver0.00.00.0-0.1
Rb content in liver1.51.91.9-1.4
Se content in liver1.21.41.41.2
Sr content in liver1.31.11.11.1
Zn content in liver0.00.00.00.1