| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | gene expression | ENSRNOG00000010165 | 0.210 | 0.110 | 0.0e+00 | 0.192 | 0.209 | 0.200 | 0.204 | 7.0e-21 | 9.7e-23 | 9.4e-22 | 3.6e-22 |
| 2 | Adipose | mRNA stability | ENSRNOG00000010165 | 0.053 | 0.063 | 2.3e-04 | 0.020 | 0.020 | 0.013 | 0.019 | 2.2e-03 | 2.6e-03 | 1.1e-02 | 3.2e-03 |
| 3 | Brain | gene expression | ENSRNOG00000010165 | 0.062 | 0.050 | 1.0e-05 | 0.035 | 0.053 | 0.039 | 0.040 | 3.1e-04 | 1.1e-05 | 1.5e-04 | 1.2e-04 |
| 4 | IL | gene expression | ENSRNOG00000010165 | 0.121 | 0.113 | 6.6e-03 | 0.045 | 0.054 | 0.052 | 0.058 | 3.0e-02 | 2.0e-02 | 2.2e-02 | 1.7e-02 |
| 5 | Liver | gene expression | ENSRNOG00000010165 | 0.220 | 0.290 | 4.8e-03 | 0.012 | 0.009 | -0.001 | 0.010 | 1.6e-02 | 3.2e-02 | 4.3e-01 | 2.3e-02 |
| 6 | Liver | mRNA stability | ENSRNOG00000010165 | 0.105 | 0.101 | 7.2e-08 | 0.043 | 0.051 | 0.035 | 0.041 | 1.5e-05 | 2.4e-06 | 8.4e-05 | 2.1e-05 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 |
|---|---|---|---|---|---|---|---|---|---|
| Delay discounting water rate 0 sec | 18.4 | 29.3 | 30.6 | -5.3 | -5.4 | -5.5 | -5.3 | -5.5 | -5.5 |
| Delay discounting time to switch 0 sec | 10.9 | 16.7 | 17.2 | 4.1 | 4.1 | 4.1 | 4.0 | 4.0 | 4.1 |
| Delay discounting water rate 12 sec | 9.5 | 14.2 | 15.4 | -3.8 | -3.9 | -3.8 | -3.6 | -3.5 | -3.8 |
| Bone: cortical tissue density | 8.5 | 11.1 | 12.0 | -3.3 | -3.2 | -3.3 | -3.2 | -3.5 | -3.4 |
| Bone: cortical apparent density | 8.4 | 10.9 | 11.8 | -3.2 | -3.2 | -3.3 | -3.2 | -3.4 | -3.4 |
| Extensor digitorum longus weight | 5.9 | 23.6 | 24.0 | -4.9 | -4.9 | -4.9 | -4.9 | -4.7 | -4.8 |
| Pavlov. Cond. lever-magazine prob. diff. | 5.9 | 7.6 | 8.0 | 2.8 | 2.8 | 2.8 | 2.8 | 2.6 | 2.7 |
| Pavlov. Cond. intertrial magazine entries | 5.5 | 6.5 | 6.7 | -2.6 | -2.5 | -2.6 | -2.6 | -2.5 | -2.6 |
| Locomotion in novel chamber | 5.5 | 6.8 | 8.8 | -2.6 | -3.0 | -2.6 | -2.4 | -2.5 | -2.6 |
| Pavlov. Cond. magazine entry latency | 5.2 | 5.9 | 6.1 | 2.4 | 2.4 | 2.4 | 2.5 | 2.4 | 2.4 |
| Pavlov. Cond. index score | 5.2 | 6.8 | 7.1 | 2.6 | 2.7 | 2.6 | 2.6 | 2.5 | 2.6 |
| Delay discounting water rate 18 sec | 5.1 | 6.7 | 8.2 | -2.7 | -2.9 | -2.6 | -2.4 | -2.4 | -2.6 |
| Pavlov. Cond. latency score | 5.1 | 6.5 | 6.7 | 2.6 | 2.6 | 2.6 | 2.5 | 2.4 | 2.5 |
| Pavlov. Cond. intertrial magazine entries | 5.0 | 6.5 | 7.5 | -2.4 | -2.4 | -2.5 | -2.5 | -2.7 | -2.6 |
| Time in open arm before self-admin | 5.0 | 5.3 | 5.7 | -2.3 | -2.1 | -2.3 | -2.3 | -2.4 | -2.4 |
| Epididymis fat weight | 4.6 | 10.8 | 11.8 | 3.3 | 3.3 | 3.3 | 3.4 | 3.2 | 3.3 |
| Delay discounting water rate 6 sec | 4.5 | 6.5 | 6.9 | -2.5 | -2.6 | -2.6 | -2.5 | -2.5 | -2.6 |
| Pavlov. Cond. change in total contacts | 4.3 | 6.0 | 6.5 | 2.5 | 2.6 | 2.5 | 2.5 | 2.3 | 2.4 |
| Pavlov. Cond. magazine entry number | 4.3 | 5.3 | 5.9 | -2.4 | -2.4 | -2.3 | -2.4 | -2.1 | -2.2 |
| Delay discounting water rate 24 sec | 4.2 | 5.8 | 7.2 | -2.5 | -2.7 | -2.4 | -2.3 | -2.1 | -2.3 |
| Pavlov. Cond. response bias | 4.1 | 5.6 | 5.8 | 2.4 | 2.4 | 2.4 | 2.3 | 2.3 | 2.4 |
| Length with tail | 4.0 | 14.6 | 15.7 | -3.8 | -3.7 | -3.9 | -3.7 | -4.0 | -3.9 |
| Intermittent access standard deviation | 3.7 | 3.9 | 4.4 | 2.0 | 2.1 | 2.0 | 1.9 | 2.0 | 2.0 |
| Liver weight, left | 3.5 | 5.6 | 6.3 | -2.5 | -2.5 | -2.4 | -2.3 | -2.1 | -2.3 |
| Tail length | 3.2 | 9.6 | 10.1 | -3.2 | -3.2 | -3.1 | -3.0 | -3.0 | -3.1 |
| Water consumed over 24 hours | 3.2 | 3.8 | 4.0 | -1.9 | -1.8 | -2.0 | -2.0 | -1.9 | -2.0 |
| Delay discounting total patch changes 12 sec | 3.1 | 4.2 | 5.5 | -1.8 | -1.8 | -2.0 | -2.0 | -2.3 | -2.2 |
| Time in open arm after self-admin | 3.1 | 3.4 | 3.8 | -1.8 | -1.7 | -1.9 | -1.8 | -1.9 | -1.9 |
| Delay discounting total patch changes 0 sec | 3.0 | 4.9 | 6.3 | -2.0 | -2.1 | -2.2 | -2.0 | -2.5 | -2.4 |
| Cocaine induced anxiety | 3.0 | 3.5 | 3.5 | -1.9 | -1.8 | -1.9 | -1.9 | -1.9 | -1.9 |
| Pavlov. Cond. lever contacts | 2.9 | 4.0 | 4.3 | 1.9 | 2.0 | 2.0 | 1.9 | 2.0 | 2.1 |
| Time in closed arm before self-admin | 2.9 | 3.4 | 3.6 | 1.8 | 1.8 | 1.8 | 1.8 | 1.9 | 1.9 |
| Indifference point 0 sec | 2.8 | 4.5 | 5.5 | -2.0 | -2.0 | -2.1 | -2.0 | -2.4 | -2.3 |
| Reaction time trials AUC | 2.8 | 4.1 | 5.2 | -1.8 | -1.8 | -2.0 | -1.9 | -2.3 | -2.2 |
| Progressive ratio test 1 inactive lever presses | 2.8 | 3.0 | 3.2 | -1.7 | -1.8 | -1.7 | -1.7 | -1.8 | -1.7 |
| Reaction time number correct | 2.7 | 3.8 | 4.9 | -1.8 | -1.8 | -1.9 | -1.9 | -2.2 | -2.1 |
| Reaction time trials correct on left | 2.7 | 3.8 | 4.9 | -1.8 | -1.8 | -1.9 | -1.9 | -2.2 | -2.1 |
| Reaction time trials on left | 2.7 | 3.8 | 4.8 | -1.8 | -1.8 | -1.9 | -1.9 | -2.2 | -2.1 |
| Reaction time trials completed | 2.7 | 3.8 | 4.8 | -1.8 | -1.8 | -1.9 | -1.9 | -2.2 | -2.1 |
| Intermitt. access day 1 inactive lever presses | 2.6 | 2.8 | 2.9 | -1.6 | -1.7 | -1.7 | -1.6 | -1.7 | -1.7 |
| Post-drug Anxiety | 2.6 | 2.9 | 2.9 | -1.7 | -1.7 | -1.7 | -1.7 | -1.7 | -1.7 |
| Indifference point AUC | 2.5 | 3.0 | 3.3 | -1.7 | -1.5 | -1.7 | -1.8 | -1.8 | -1.8 |
| Cocaine response before conditioning | 2.5 | 3.0 | 3.2 | 1.8 | 1.8 | 1.8 | 1.8 | 1.6 | 1.7 |
| Bouts of movement, locomotor time 2 | 2.5 | 2.6 | 3.3 | -1.7 | -1.8 | -1.6 | -1.8 | -1.3 | -1.5 |
| BMI with tail | 2.4 | 7.7 | 7.9 | 2.8 | 2.7 | 2.8 | 2.8 | 2.8 | 2.8 |
| Condit. Reinf. active-inactive response ratio | 2.4 | 2.6 | 3.2 | 1.6 | 1.6 | 1.6 | 1.5 | 1.8 | 1.7 |
| Reaction time premature initiations | 2.3 | 3.3 | 4.4 | -1.7 | -1.7 | -1.8 | -1.8 | -2.1 | -1.9 |
| Intermittent access terminal intake (last 3 days) | 2.3 | 2.5 | 2.8 | 1.6 | 1.7 | 1.6 | 1.6 | 1.6 | 1.5 |
| Pavlov. Cond. lever latency | 2.1 | 2.9 | 3.1 | -1.7 | -1.7 | -1.7 | -1.6 | -1.7 | -1.8 |
| Conditioned reinforcement - actives | 2.0 | 2.0 | 2.2 | -1.3 | -1.3 | -1.4 | -1.4 | -1.5 | -1.4 |
| Intermittent access day 15 total infusions | 2.0 | 2.2 | 2.3 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.4 |
| Food seeking constrained by brief footshock | 2.0 | 2.4 | 2.9 | -1.6 | -1.6 | -1.6 | -1.7 | -1.4 | -1.5 |
| Condit. Reinf. inactive responses | 1.9 | 2.2 | 2.5 | -1.4 | -1.4 | -1.5 | -1.5 | -1.6 | -1.5 |
| Bone: stiffness | 1.9 | 2.9 | 3.7 | -1.8 | -1.9 | -1.7 | -1.8 | -1.4 | -1.6 |
| Total resting periods, locomotor time 2 | 1.9 | 2.0 | 2.8 | -1.5 | -1.7 | -1.4 | -1.5 | -1.1 | -1.3 |
| Cocaine response after cond. not corrected | 1.8 | 2.0 | 2.2 | 1.4 | 1.3 | 1.4 | 1.4 | 1.5 | 1.4 |
| Context. condit. distance diff. score | 1.8 | 2.1 | 2.4 | -1.4 | -1.4 | -1.5 | -1.5 | -1.5 | -1.5 |
| Delay discounting total patch changes 6 sec | 1.7 | 2.6 | 3.4 | -1.5 | -1.5 | -1.6 | -1.4 | -1.8 | -1.8 |
| Time in closed arm after self-admin | 1.7 | 1.8 | 1.9 | 1.3 | 1.3 | 1.3 | 1.4 | 1.4 | 1.4 |
| Time to tail flick, test, after self-admin | 1.7 | 1.8 | 1.8 | -1.3 | -1.2 | -1.4 | -1.3 | -1.4 | -1.4 |
| Length without tail | 1.6 | 3.4 | 4.6 | -1.7 | -1.5 | -1.8 | -1.8 | -2.1 | -2.0 |
| Locomotor testing rearing | 1.6 | 2.5 | 3.2 | 1.8 | 1.7 | 1.6 | 1.6 | 1.3 | 1.5 |
| Condit. Reinf. lever presses | 1.6 | 2.3 | 2.5 | 1.5 | 1.6 | 1.5 | 1.4 | 1.4 | 1.5 |
| Intermittent access intake escalation | 1.6 | 1.6 | 1.7 | 1.2 | 1.3 | 1.3 | 1.2 | 1.3 | 1.3 |
| Baseline Anxiety | 1.5 | 1.6 | 1.7 | 1.3 | 1.2 | 1.3 | 1.3 | 1.3 | 1.3 |
| Fecal boli incidents, locomotor time 1 | 1.5 | 1.6 | 2.5 | 1.1 | 1.4 | 1.2 | 1.0 | 1.6 | 1.4 |
| Intermittent access intake day 1-15 change | 1.4 | 1.4 | 1.5 | 1.2 | 1.2 | 1.2 | 1.1 | 1.2 | 1.2 |
| Bone: cortical area | 1.4 | 2.1 | 2.8 | -1.6 | -1.7 | -1.4 | -1.6 | -1.0 | -1.2 |
| Light reinforcement 2 | 1.3 | 1.7 | 2.7 | 1.2 | 1.0 | 1.3 | 1.2 | 1.6 | 1.4 |
| Pavlov. Cond. response bias | 1.3 | 1.5 | 1.6 | 1.3 | 1.3 | 1.2 | 1.1 | 1.3 | 1.2 |
| Active lever presses in extinction session 6 | 1.3 | 1.2 | 1.3 | -1.1 | -1.1 | -1.1 | -1.1 | -1.1 | -1.1 |
| Delay discounting total patch changes 18 sec | 1.2 | 1.5 | 2.9 | -1.0 | -0.8 | -1.2 | -1.2 | -1.7 | -1.4 |
| Reaction time num false alarms AUC | 1.2 | 1.7 | 1.9 | -1.2 | -1.4 | -1.3 | -1.1 | -1.4 | -1.4 |
| Intermittent access day 1 locomotion | 1.2 | 1.2 | 1.7 | 1.1 | 1.3 | 1.0 | 1.0 | 1.0 | 1.0 |
| Bone: cortical thickness | 1.2 | 2.1 | 2.9 | -1.5 | -1.7 | -1.4 | -1.6 | -1.0 | -1.2 |
| Reaction time omissions | 1.1 | 1.4 | 1.8 | -1.2 | -1.3 | -1.2 | -1.1 | -1.2 | -1.1 |
| Conditioned locomotion | 1.1 | 1.3 | 1.4 | -1.1 | -1.1 | -1.1 | -1.1 | -1.2 | -1.2 |
| Pavlov. Cond. magazine entry number | 1.1 | 1.4 | 1.5 | -1.2 | -1.2 | -1.2 | -1.1 | -1.2 | -1.2 |
| Bone: post-yield work | 1.1 | 1.4 | 1.5 | -1.2 | -1.2 | -1.2 | -1.2 | -1.1 | -1.2 |
| Delta time to tail flick, test, before/after SA | 1.1 | 1.0 | 1.6 | -1.0 | -1.3 | -1.0 | -0.9 | -0.9 | -0.9 |
| Total heroin consumption | 1.1 | 1.3 | 1.7 | -1.3 | -0.9 | -1.2 | -1.3 | -1.0 | -1.2 |
| Run reversals in cocaine runway, females | 1.1 | 1.1 | 1.4 | 1.1 | 1.0 | 1.1 | 1.2 | 0.9 | 1.0 |
| Mean time between licks in bursts | 1.0 | 1.3 | 1.5 | 1.1 | 1.2 | 1.1 | 1.1 | 1.2 | 1.2 |
| Bone: cortical thickness | 1.0 | 1.2 | 1.9 | -1.2 | -1.4 | -1.1 | -1.1 | -0.7 | -0.9 |
| Total resting periods, locomotor time 1 | 1.0 | 1.1 | 1.5 | 1.0 | 1.1 | 1.0 | 0.8 | 1.2 | 1.1 |
| Cu content in liver | 1.0 | 1.2 | 1.3 | 1.0 | 1.0 | 1.1 | 1.1 | 1.1 | 1.1 |
| Reaction time mean | 0.9 | 1.2 | 1.4 | 1.1 | 1.0 | 1.1 | 1.2 | 1.0 | 1.1 |
| Conditioned locomotion | 0.9 | 1.1 | 1.7 | 1.0 | 1.3 | 1.0 | 0.9 | 1.0 | 1.0 |
| Intermitt. access day 15 inactive lever presses | 0.9 | 1.0 | 1.3 | -0.9 | -1.1 | -0.9 | -0.9 | -1.1 | -0.9 |
| Intermittent access total infusions | 0.9 | 0.9 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 0.9 | 0.9 |
| Short access day 1 locomotion | 0.9 | 1.0 | 1.4 | 1.1 | 1.2 | 1.0 | 1.0 | 0.8 | 0.9 |
| Time in familiar zone, hab. session 2 | 0.9 | 0.9 | 1.3 | 1.1 | 1.1 | 1.0 | 1.0 | 0.6 | 0.8 |
| Pavlov. Cond. index score | 0.9 | 1.1 | 1.4 | 1.0 | 1.1 | 1.1 | 1.0 | 1.2 | 1.1 |
| Pavlov. Cond. lever contacts | 0.9 | 1.0 | 1.1 | 1.0 | 1.0 | 1.0 | 1.0 | 1.1 | 1.0 |
| Bouts of movement, locomotor time 1 | 0.9 | 1.0 | 1.5 | 0.9 | 1.1 | 1.0 | 0.7 | 1.2 | 1.1 |
| Run reversals in cocaine runway, males | 0.9 | 0.9 | 1.0 | -0.9 | -0.9 | -1.0 | -1.0 | -1.0 | -1.0 |
| Glucose | 0.8 | 1.2 | 1.3 | -1.0 | -1.1 | -1.1 | -1.1 | -1.2 | -1.1 |
| Reaction time premature initiation rate | 0.8 | 1.1 | 1.5 | -0.9 | -1.0 | -1.0 | -1.1 | -1.2 | -1.0 |
| Social time | 0.8 | 1.1 | 1.2 | -1.0 | -1.1 | -1.0 | -1.1 | -1.0 | -1.0 |
| Progressive ratio test 2 inactive lever presses | 0.8 | 0.9 | 1.2 | -0.9 | -0.9 | -0.9 | -0.9 | -1.1 | -1.0 |
| Short access day 10 total locomotion | 0.8 | 0.9 | 1.6 | 0.9 | 1.3 | 0.9 | 0.9 | 0.8 | 0.8 |
| Locomotion distance, session 7 | 0.8 | 1.0 | 1.2 | 1.1 | 1.1 | 1.0 | 1.0 | 0.9 | 1.0 |
| Stereotopy head waving bouts, day 7 | 0.8 | 0.9 | 1.0 | -0.9 | -1.0 | -1.0 | -0.9 | -1.0 | -1.0 |
| Time in familiar zone, hab. session 1 | 0.8 | 0.7 | 1.1 | 1.0 | 1.0 | 0.9 | 0.9 | 0.5 | 0.7 |
| Co content in liver | 0.8 | 0.9 | 1.0 | -1.0 | -0.9 | -0.9 | -1.0 | -1.0 | -1.0 |
| Std. dev. time between licks in bursts | 0.7 | 0.8 | 1.1 | 0.8 | 0.8 | 0.9 | 0.8 | 1.0 | 1.0 |
| Reaction time num false alarms | 0.7 | 0.9 | 1.2 | -0.8 | -1.0 | -1.0 | -0.8 | -1.1 | -1.1 |
| Condit. Reinf. inactive responses | 0.7 | 0.8 | 1.0 | 0.9 | 0.8 | 0.9 | 1.0 | 0.8 | 0.9 |
| Locomotion velocity, hab. session 2 | 0.7 | 0.9 | 1.2 | -1.0 | -1.1 | -0.9 | -1.0 | -0.8 | -0.9 |
| Pavlov. Cond. lever latency | 0.7 | 0.8 | 1.0 | -0.9 | -0.9 | -0.9 | -0.9 | -1.0 | -0.9 |
| Bone: elastic displacement | 0.7 | 0.8 | 1.0 | -0.9 | -1.0 | -0.9 | -0.9 | -0.8 | -0.8 |
| Bone: minimum diameter | 0.7 | 1.3 | 1.5 | -1.2 | -1.2 | -1.2 | -1.2 | -1.0 | -1.1 |
| Time to tail flick, vehicle, before self-admin | 0.7 | 0.7 | 1.0 | -0.9 | -1.0 | -0.8 | -0.8 | -0.7 | -0.8 |
| Reaction time mean AUC | 0.6 | 0.7 | 0.9 | 0.8 | 0.8 | 0.9 | 1.0 | 0.8 | 0.9 |
| Median of all reaction times | 0.6 | 0.8 | 1.0 | 0.9 | 0.9 | 0.9 | 1.0 | 0.8 | 0.9 |
| Intermittent access total locomotion | 0.6 | 0.6 | 1.0 | 0.8 | 1.0 | 0.8 | 0.7 | 0.8 | 0.7 |
| Pavlov. Cond. latency score | 0.6 | 0.7 | 0.9 | 0.8 | 0.9 | 0.8 | 0.8 | 1.0 | 0.9 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.6 | 0.8 | 1.0 | 0.8 | 0.9 | 0.9 | 0.7 | 1.0 | 0.9 |
| Delta ambulatory time before/after self-admin | 0.6 | 0.6 | 0.7 | -0.8 | -0.8 | -0.7 | -0.8 | -0.8 | -0.7 |
| Time >=10cm from walls, locomotor time 2 | 0.6 | 0.6 | 0.9 | -0.8 | -0.5 | -0.8 | -1.0 | -0.8 | -0.8 |
| BMI without tail | 0.5 | 0.9 | 1.5 | 0.8 | 0.7 | 1.0 | 1.0 | 1.2 | 1.1 |
| Left kidney weight | 0.5 | 1.5 | 2.3 | -1.1 | -1.2 | -1.2 | -1.0 | -1.5 | -1.3 |
| Tibia length | 0.5 | 1.4 | 1.8 | -1.3 | -1.3 | -1.2 | -1.4 | -0.9 | -1.1 |
| Indifference point function ln k | 0.5 | 0.6 | 0.8 | -0.8 | -0.9 | -0.8 | -0.8 | -0.6 | -0.8 |
| Indifference point function log k | 0.5 | 0.6 | 0.8 | -0.8 | -0.9 | -0.8 | -0.8 | -0.6 | -0.8 |
| Short access day 10 total infusions | 0.5 | 0.6 | 0.7 | 0.8 | 0.9 | 0.7 | 0.8 | 0.6 | 0.7 |
| Condit. Reinf. active minus inactive responses | 0.5 | 0.6 | 0.9 | 0.7 | 0.7 | 0.7 | 0.7 | 0.9 | 0.8 |
| Total zone transitions, hab. session 1 | 0.5 | 0.7 | 1.0 | 0.8 | 0.8 | 0.8 | 0.8 | 1.0 | 0.9 |
| Total zone transitions, hab. session 2 | 0.5 | 0.7 | 1.0 | 0.7 | 0.8 | 0.8 | 0.7 | 1.0 | 0.9 |
| Total locomotion distance, hab. session 2 | 0.5 | 0.6 | 0.9 | -0.9 | -1.0 | -0.8 | -0.8 | -0.6 | -0.7 |
| Pavlov. Cond. magazine entry latency | 0.5 | 0.7 | 0.8 | 0.9 | 0.9 | 0.8 | 0.7 | 0.8 | 0.8 |
| Bone: final moment | 0.5 | 0.9 | 1.3 | -1.1 | -1.1 | -0.9 | -1.1 | -0.6 | -0.7 |
| Distance traveled after self-admin | 0.5 | 0.6 | 1.1 | -0.8 | -1.0 | -0.7 | -0.7 | -0.7 | -0.7 |
| Delta time in open arm before/after self-admin | 0.5 | 0.4 | 0.5 | -0.7 | -0.5 | -0.7 | -0.7 | -0.7 | -0.7 |
| Time >=10cm from walls, locomotor time 1 | 0.5 | 0.5 | 0.5 | 0.7 | 0.7 | 0.7 | 0.6 | 0.7 | 0.7 |
| Distance moved, locomotor task time 1 | 0.5 | 0.5 | 0.8 | 0.8 | 0.7 | 0.7 | 0.9 | 0.4 | 0.6 |
| Vertical activity count, locomotor time 1 | 0.5 | 0.5 | 0.8 | -0.6 | -0.6 | -0.7 | -0.6 | -0.9 | -0.8 |
| Rest time, locomotor task time 2 | 0.5 | 0.6 | 1.3 | -0.8 | -1.1 | -0.7 | -0.6 | -0.5 | -0.6 |
| Progressive ratio | 0.5 | 0.5 | 0.6 | -0.8 | -0.7 | -0.7 | -0.8 | -0.7 | -0.7 |
| Cd content in liver | 0.5 | 0.6 | 0.8 | -0.9 | -0.9 | -0.8 | -0.7 | -0.5 | -0.7 |
| Rb content in liver | 0.5 | 0.7 | 1.0 | -0.7 | -0.6 | -0.8 | -0.7 | -1.0 | -0.9 |
| Cocaine response after cond. corrected | 0.4 | 0.5 | 0.7 | 0.7 | 0.6 | 0.7 | 0.7 | 0.8 | 0.7 |
| Condit. Reinf. active-inactive response ratio | 0.4 | 0.4 | 0.6 | -0.6 | -0.5 | -0.6 | -0.7 | -0.8 | -0.7 |
| Intermittent access day 1 total infusions | 0.4 | 0.5 | 0.6 | 0.7 | 0.8 | 0.7 | 0.7 | 0.7 | 0.7 |
| Intermittent access day 15 total locomotion | 0.4 | 0.5 | 0.8 | 0.6 | 0.9 | 0.6 | 0.6 | 0.7 | 0.6 |
| Lifetime Intake | 0.4 | 0.5 | 0.6 | 0.8 | 0.8 | 0.7 | 0.7 | 0.6 | 0.7 |
| Short access day 10 total inactive lever presses | 0.4 | 0.5 | 0.6 | -0.7 | -0.8 | -0.7 | -0.6 | -0.6 | -0.7 |
| Number of responses in last shaping day | 0.4 | 0.4 | 0.7 | 0.5 | 0.6 | 0.6 | 0.5 | 0.8 | 0.6 |
| Locomotion velocity, session 7 | 0.4 | 0.4 | 0.7 | 0.8 | 0.8 | 0.7 | 0.7 | 0.3 | 0.6 |
| Incentive salience index mean | 0.4 | 0.5 | 0.8 | 0.7 | 0.8 | 0.7 | 0.6 | 0.9 | 0.7 |
| Locomotion velocity, hab. session 1 | 0.4 | 0.5 | 0.7 | -0.7 | -0.8 | -0.7 | -0.7 | -0.7 | -0.7 |
| Pavlov. Cond. change in total contacts | 0.4 | 0.4 | 0.5 | 0.7 | 0.7 | 0.6 | 0.6 | 0.5 | 0.5 |
| Bone: final force | 0.4 | 0.7 | 1.0 | -0.9 | -1.0 | -0.8 | -1.0 | -0.5 | -0.7 |
| Bone: maximum force | 0.4 | 0.7 | 1.0 | -1.0 | -1.0 | -0.8 | -1.0 | -0.6 | -0.7 |
| Bone: maximum moment | 0.4 | 0.7 | 1.1 | -1.0 | -1.0 | -0.8 | -1.0 | -0.5 | -0.6 |
| Distance moved, locomotor task time 2 | 0.4 | 0.4 | 0.9 | 0.8 | 0.9 | 0.7 | 0.6 | 0.3 | 0.5 |
| Vertical activity count, locomotor time 2 | 0.4 | 0.5 | 0.7 | -0.6 | -0.4 | -0.7 | -0.8 | -0.8 | -0.7 |
| Sr content in liver | 0.4 | 0.4 | 0.6 | -0.8 | -0.7 | -0.6 | -0.7 | -0.4 | -0.5 |
| Right kidney weight | 0.3 | 0.7 | 1.1 | -0.7 | -1.0 | -0.8 | -0.6 | -1.1 | -0.9 |
| Tibialis anterior weight | 0.3 | 1.1 | 1.2 | -1.0 | -1.1 | -1.1 | -1.1 | -1.0 | -1.0 |
| Times rat made contact with spout | 0.3 | 0.3 | 0.4 | -0.5 | -0.4 | -0.6 | -0.6 | -0.6 | -0.6 |
| Condit. Reinf. active minus inactive responses | 0.3 | 0.4 | 0.6 | -0.6 | -0.4 | -0.6 | -0.7 | -0.8 | -0.7 |
| Conditioned reinforcement - inactives | 0.3 | 0.4 | 0.4 | -0.6 | -0.6 | -0.6 | -0.6 | -0.6 | -0.6 |
| Intermitt. access escalation Index | 0.3 | 0.3 | 0.4 | -0.5 | -0.5 | -0.5 | -0.4 | -0.5 | -0.6 |
| Short access total infusions | 0.3 | 0.3 | 0.4 | 0.6 | 0.6 | 0.6 | 0.5 | 0.4 | 0.5 |
| Locomotion velocity, session 1 | 0.3 | 0.4 | 0.6 | -0.7 | -0.6 | -0.6 | -0.8 | -0.4 | -0.5 |
| Locomotion distance, session 1 | 0.3 | 0.3 | 0.5 | 0.5 | 0.7 | 0.6 | 0.4 | 0.7 | 0.6 |
| Stereotopy head waving duration, day 7 | 0.3 | 0.3 | 0.4 | -0.5 | -0.5 | -0.6 | -0.5 | -0.6 | -0.6 |
| Delay disc. indifference point, 8s delay | 0.3 | 0.3 | 0.5 | 0.6 | 0.7 | 0.5 | 0.6 | 0.4 | 0.4 |
| Rest time, locomotor task time 1 | 0.3 | 0.3 | 0.5 | -0.6 | -0.7 | -0.6 | -0.6 | -0.4 | -0.5 |
| Seeking ratio, delayed vs. immediate footshock | 0.3 | 0.4 | 0.7 | -0.6 | -0.3 | -0.6 | -0.8 | -0.6 | -0.6 |
| Retroperitoneal fat weight | 0.2 | 0.6 | 0.9 | 0.7 | 0.7 | 0.7 | 0.9 | 0.9 | 0.8 |
| Locomotor testing distance | 0.2 | 0.3 | 0.4 | -0.4 | -0.6 | -0.5 | -0.4 | -0.6 | -0.6 |
| Std. dev. reaction times | 0.2 | 0.3 | 0.5 | 0.5 | 0.4 | 0.6 | 0.6 | 0.7 | 0.7 |
| Social response proportion | 0.2 | 0.2 | 0.5 | -0.4 | -0.3 | -0.5 | -0.4 | -0.7 | -0.6 |
| Saline control response | 0.2 | 0.3 | 0.3 | 0.5 | 0.5 | 0.5 | 0.4 | 0.6 | 0.6 |
| Progressive ratio test 1 breakpoint | 0.2 | 0.2 | 0.3 | 0.4 | 0.5 | 0.4 | 0.4 | 0.2 | 0.3 |
| Short access day 1 total infusions | 0.2 | 0.2 | 0.3 | -0.4 | -0.4 | -0.4 | -0.4 | -0.5 | -0.5 |
| Short access total locomotion | 0.2 | 0.2 | 0.5 | 0.4 | 0.7 | 0.3 | 0.3 | 0.2 | 0.3 |
| Locomotion distance, session 2 | 0.2 | 0.4 | 0.4 | 0.5 | 0.6 | 0.6 | 0.5 | 0.7 | 0.6 |
| Locomotion velocity, session 3 | 0.2 | 0.2 | 0.3 | 0.6 | 0.6 | 0.5 | 0.5 | 0.3 | 0.4 |
| Stereotopy head waving duration, day 3 | 0.2 | 0.2 | 0.3 | -0.4 | -0.4 | -0.5 | -0.6 | -0.4 | -0.5 |
| Degree of sensitization stereotypy | 0.2 | 0.2 | 0.2 | -0.4 | -0.5 | -0.4 | -0.4 | -0.4 | -0.4 |
| Condit. Reinf. active responses | 0.2 | 0.2 | 0.3 | 0.5 | 0.5 | 0.5 | 0.4 | 0.5 | 0.4 |
| Novel to familiar place preference ratio | 0.2 | 0.3 | 0.4 | 0.4 | 0.4 | 0.5 | 0.5 | 0.6 | 0.6 |
| Novelty place preference | 0.2 | 0.2 | 0.2 | 0.3 | 0.3 | 0.4 | 0.4 | 0.5 | 0.5 |
| Bone: cortical porosity | 0.2 | 0.2 | 0.3 | 0.5 | 0.4 | 0.5 | 0.4 | 0.6 | 0.5 |
| Bone: elastic work | 0.2 | 0.3 | 0.5 | -0.6 | -0.7 | -0.5 | -0.6 | -0.3 | -0.4 |
| Bone: endosteal estimation | 0.2 | 0.3 | 0.5 | 0.5 | 0.6 | 0.6 | 0.4 | 0.7 | 0.6 |
| Bone: periosteal estimation | 0.2 | 0.4 | 0.6 | -0.8 | -0.7 | -0.6 | -0.8 | -0.2 | -0.4 |
| Bone: tissue strength | 0.2 | 0.2 | 0.4 | -0.5 | -0.6 | -0.4 | -0.5 | -0.2 | -0.3 |
| Bone: trabecular tissue density | 0.2 | 0.2 | 0.6 | -0.3 | -0.3 | -0.4 | -0.3 | -0.8 | -0.6 |
| Sum of active levers in priming session hrs 5-6 | 0.2 | 0.2 | 0.2 | 0.4 | 0.4 | 0.4 | 0.4 | 0.3 | 0.4 |
| Time to tail flick, vehicle, after self-admin | 0.2 | 0.3 | 0.4 | 0.5 | 0.6 | 0.5 | 0.4 | 0.5 | 0.5 |
| Delta time to tail flick, vehicle, before/after SA | 0.2 | 0.2 | 0.5 | 0.5 | 0.7 | 0.4 | 0.3 | 0.2 | 0.3 |
| Latency to leave start box in cocaine runway | 0.2 | 0.2 | 0.4 | 0.6 | 0.6 | 0.5 | 0.5 | 0.2 | 0.3 |
| Latency to leave start box in cocaine runway, F | 0.2 | 0.3 | 0.5 | 0.6 | 0.7 | 0.5 | 0.5 | 0.1 | 0.3 |
| Zn content in liver | 0.2 | 0.3 | 0.3 | -0.6 | -0.5 | -0.5 | -0.6 | -0.4 | -0.5 |
| Body weight | 0.1 | 0.4 | 0.5 | -0.6 | -0.6 | -0.6 | -0.6 | -0.7 | -0.7 |
| Intraocular pressure | 0.1 | 0.1 | 0.1 | 0.3 | 0.3 | 0.3 | 0.2 | 0.3 | 0.3 |
| Number of licking bursts | 0.1 | 0.1 | 0.2 | -0.4 | -0.5 | -0.4 | -0.4 | -0.3 | -0.3 |
| Food consumed during 24 hour testing period | 0.1 | 0.2 | 0.2 | -0.5 | -0.4 | -0.4 | -0.4 | -0.3 | -0.3 |
| Delay discounting total patch changes 24 sec | 0.1 | 0.1 | 0.2 | -0.2 | -0.1 | -0.3 | -0.2 | -0.5 | -0.5 |
| Reaction time mean minus median | 0.1 | 0.1 | 0.2 | 0.3 | 0.2 | 0.3 | 0.3 | 0.3 | 0.4 |
| Reaction time mean minus median AUC | 0.1 | 0.1 | 0.2 | 0.2 | 0.2 | 0.3 | 0.3 | 0.3 | 0.4 |
| Reaction time false alarm rate | 0.1 | 0.1 | 0.3 | -0.3 | -0.5 | -0.3 | -0.2 | -0.2 | -0.3 |
| Social responses | 0.1 | 0.1 | 0.2 | 0.3 | 0.4 | 0.3 | 0.3 | 0.2 | 0.3 |
| Intermittent access intake escalation 2 | 0.1 | 0.1 | 0.2 | 0.3 | 0.3 | 0.3 | 0.2 | 0.4 | 0.4 |
| Total sessions with >9 infusions | 0.1 | 0.1 | 0.4 | 0.4 | 0.7 | 0.3 | 0.2 | 0.1 | 0.3 |
| Short access day 1 total inactive lever presses | 0.1 | 0.1 | 0.1 | 0.4 | 0.2 | 0.3 | 0.4 | 0.2 | 0.2 |
| Locomotion velocity, session 2 | 0.1 | 0.1 | 0.2 | 0.3 | 0.4 | 0.2 | 0.2 | -0.2 | 0.0 |
| Stereotopy head waving bouts, day 3 | 0.1 | 0.1 | 0.2 | -0.4 | -0.3 | -0.4 | -0.5 | -0.3 | -0.4 |
| Locomotion velocity, session 8 | 0.1 | 0.2 | 0.3 | -0.3 | -0.3 | -0.4 | -0.4 | -0.5 | -0.5 |
| Degree of sensitization distance | 0.1 | 0.1 | 0.2 | 0.4 | 0.5 | 0.4 | 0.4 | 0.2 | 0.3 |
| Condit. Reinf. lever presses | 0.1 | 0.1 | 0.3 | 0.4 | 0.6 | 0.4 | 0.2 | 0.3 | 0.3 |
| Time in novel zone, NPP test | 0.1 | 0.1 | 0.2 | 0.3 | 0.2 | 0.3 | 0.3 | 0.4 | 0.4 |
| Total zone transitions, NPP test | 0.1 | 0.1 | 0.3 | 0.2 | 0.2 | 0.3 | 0.2 | 0.5 | 0.4 |
| Total locomotion distance, NPP test | 0.1 | 0.1 | 0.3 | -0.4 | -0.5 | -0.3 | -0.3 | 0.0 | -0.1 |
| Locomotion velocity, NPP test | 0.1 | 0.1 | 0.3 | -0.5 | -0.6 | -0.3 | -0.3 | -0.0 | -0.2 |
| Bone: marrow area | 0.1 | 0.3 | 0.5 | 0.4 | 0.6 | 0.5 | 0.3 | 0.7 | 0.6 |
| Bone: maximum diameter | 0.1 | 0.2 | 0.4 | -0.6 | -0.6 | -0.5 | -0.6 | 0.0 | -0.3 |
| Bone: periosteal perimeter | 0.1 | 0.2 | 0.4 | -0.6 | -0.6 | -0.5 | -0.6 | -0.0 | -0.3 |
| Bone: trabecular thickness | 0.1 | 0.1 | 0.2 | -0.4 | -0.4 | -0.4 | -0.4 | -0.4 | -0.4 |
| Delta time in closed arm before/after self-admin | 0.1 | 0.1 | 0.1 | 0.2 | 0.1 | 0.2 | 0.3 | 0.3 | 0.2 |
| Time to tail flick, test, before self-admin | 0.1 | 0.1 | 0.1 | -0.2 | -0.0 | -0.2 | -0.3 | -0.3 | -0.3 |
| Ambulatory time before self-admin | 0.1 | 0.1 | 0.2 | 0.3 | 0.3 | 0.3 | 0.4 | 0.3 | 0.3 |
| Area under the delay curve | 0.1 | 0.1 | 0.1 | 0.4 | 0.4 | 0.3 | 0.4 | 0.2 | 0.3 |
| Delay disc. indifference point, 0s delay | 0.1 | 0.1 | 0.1 | -0.2 | -0.1 | -0.2 | -0.2 | -0.3 | -0.3 |
| Delay disc. indifference point, 4s delay | 0.1 | 0.1 | 0.2 | -0.2 | -0.0 | -0.3 | -0.2 | -0.4 | -0.4 |
| Delay discount exponential model param | 0.1 | 0.1 | 0.1 | -0.3 | -0.3 | -0.2 | -0.3 | -0.2 | -0.2 |
| Delay discount hyperbolic model param | 0.1 | 0.1 | 0.1 | -0.3 | -0.3 | -0.3 | -0.3 | -0.2 | -0.2 |
| Change in fecal boli incidents, locomotor task | 0.1 | 0.1 | 0.2 | -0.2 | -0.3 | -0.3 | -0.1 | -0.5 | -0.4 |
| Seeking ratio, punishment vs. effort | 0.1 | 0.1 | 0.2 | -0.3 | -0.4 | -0.3 | -0.3 | -0.2 | -0.3 |
| Latency to leave start box in cocaine runway, M | 0.1 | 0.1 | 0.2 | 0.3 | 0.2 | 0.3 | 0.4 | 0.3 | 0.3 |
| Fe content in liver | 0.1 | 0.1 | 0.2 | 0.3 | 0.3 | 0.3 | 0.4 | 0.3 | 0.3 |
| K content in liver | 0.1 | 0.1 | 0.2 | -0.2 | -0.2 | -0.3 | -0.2 | -0.4 | -0.3 |
| Heart weight | 0.0 | 0.0 | 0.1 | 0.2 | 0.2 | 0.1 | 0.2 | -0.0 | 0.1 |
| Liver weight, right | 0.0 | 0.0 | 0.0 | -0.0 | 0.0 | -0.1 | 0.0 | -0.1 | -0.1 |
| Parametrial fat weight | 0.0 | 0.0 | 0.0 | -0.2 | 0.0 | -0.1 | -0.0 | 0.0 | -0.0 |
| Soleus weight | 0.0 | 0.1 | 0.1 | 0.3 | 0.1 | 0.2 | 0.3 | 0.3 | 0.2 |
| Mean num. licks in bursts | 0.0 | 0.0 | 0.0 | 0.1 | 0.2 | 0.1 | 0.0 | -0.0 | -0.0 |
| Locomotor activity | 0.0 | 0.1 | 0.2 | -0.2 | -0.4 | -0.2 | -0.0 | -0.3 | -0.3 |
| Light reinforcement 1 | 0.0 | 0.0 | 0.1 | 0.3 | 0.1 | 0.2 | 0.2 | 0.2 | 0.1 |
| Condit. Reinf. active responses | 0.0 | 0.0 | 0.1 | 0.1 | 0.3 | 0.1 | 0.1 | -0.1 | 0.0 |
| Condit. Reinf. lever reinforcers received | 0.0 | 0.0 | 0.1 | 0.2 | 0.3 | 0.2 | 0.1 | -0.1 | 0.1 |
| Incentive Sensitization - Responses | 0.0 | 0.0 | 0.0 | 0.1 | -0.1 | 0.1 | 0.2 | 0.1 | 0.1 |
| Incentive Sensitization - Breakpoint | 0.0 | 0.0 | 0.0 | 0.0 | -0.2 | 0.0 | 0.1 | -0.0 | -0.0 |
| Progressive ratio test 1 active lever presses | 0.0 | 0.0 | 0.1 | 0.3 | 0.3 | 0.2 | 0.2 | 0.1 | 0.2 |
| Progressive ratio test 2 active lever presses | 0.0 | 0.0 | 0.0 | 0.2 | 0.1 | 0.2 | 0.2 | 0.0 | 0.1 |
| Progressive ratio test 2 breakpoint | 0.0 | 0.0 | 0.0 | 0.2 | 0.1 | 0.1 | 0.2 | 0.0 | 0.1 |
| Compulsive drug intake | 0.0 | 0.0 | 0.0 | 0.1 | -0.1 | 0.1 | 0.2 | 0.2 | 0.1 |
| One hour access (0.3 mA shock) | 0.0 | 0.1 | 0.1 | -0.2 | -0.2 | -0.2 | -0.2 | -0.3 | -0.3 |
| One hour access (shock baseline) | 0.0 | 0.0 | 0.1 | 0.2 | 0.3 | 0.2 | 0.1 | 0.1 | 0.2 |
| Locomotion distance, session 3 | 0.0 | 0.0 | 0.1 | -0.2 | -0.3 | -0.1 | -0.2 | -0.1 | -0.1 |
| Locomotion distance, session 8 | 0.0 | 0.0 | 0.0 | 0.0 | 0.1 | 0.1 | -0.1 | 0.2 | 0.1 |
| Time in novel zone, hab. session 1 | 0.0 | 0.0 | 0.2 | -0.1 | -0.1 | 0.0 | 0.1 | 0.4 | 0.2 |
| Total locomotion distance, hab. session 1 | 0.0 | 0.0 | 0.1 | -0.2 | -0.3 | -0.1 | -0.1 | -0.1 | -0.1 |
| Time in novel zone, hab. session 2 | 0.0 | 0.0 | 0.1 | -0.2 | -0.2 | -0.1 | -0.0 | 0.3 | 0.1 |
| Bone: apparent density | 0.0 | 0.1 | 0.1 | 0.3 | 0.2 | 0.3 | 0.2 | 0.2 | 0.3 |
| Bone surface | 0.0 | 0.0 | 0.1 | 0.0 | 0.1 | 0.1 | -0.0 | 0.3 | 0.2 |
| Bone volume | 0.0 | 0.0 | 0.1 | 0.1 | 0.1 | 0.2 | 0.1 | 0.3 | 0.2 |
| Bone: connectivity density | 0.0 | 0.0 | 0.1 | -0.2 | -0.2 | -0.2 | -0.2 | -0.3 | -0.2 |
| Bone: cortical porosity | 0.0 | 0.0 | 0.0 | 0.1 | 0.0 | 0.1 | 0.0 | 0.1 | 0.0 |
| Bone: endosteal perimeter | 0.0 | 0.0 | 0.1 | -0.2 | -0.1 | -0.1 | -0.2 | 0.2 | 0.0 |
| Bone: trabecular number | 0.0 | 0.0 | 0.1 | -0.0 | -0.1 | -0.1 | -0.0 | -0.3 | -0.2 |
| Bone: trabecular spacing | 0.0 | 0.0 | 0.2 | 0.0 | -0.0 | 0.1 | 0.1 | 0.4 | 0.2 |
| Breakpoint value in progressive ratio session | 0.0 | 0.0 | 0.0 | -0.0 | 0.2 | 0.0 | -0.0 | 0.1 | 0.1 |
| Distance traveled before self-admin | 0.0 | 0.0 | 0.1 | 0.1 | 0.2 | 0.1 | 0.3 | 0.2 | 0.2 |
| Diff in mean of infusions in LGA sessions | 0.0 | 0.0 | 0.0 | -0.1 | 0.2 | -0.1 | -0.2 | -0.1 | -0.1 |
| Extinction: sum of active levers before priming | 0.0 | 0.0 | 0.0 | 0.0 | -0.0 | 0.1 | 0.0 | 0.0 | 0.1 |
| Delta distance traveled before/after self-admin | 0.0 | 0.0 | 0.1 | -0.1 | -0.3 | -0.1 | -0.2 | -0.2 | -0.1 |
| Ambulatory time after self-admin | 0.0 | 0.0 | 0.0 | 0.1 | -0.2 | 0.1 | 0.1 | 0.1 | 0.1 |
| Delay disc. indifference point, 16s delay | 0.0 | 0.0 | 0.1 | 0.3 | 0.1 | 0.2 | 0.2 | 0.1 | 0.1 |
| Delay disc. indifference point, 2s delay | 0.0 | 0.0 | 0.1 | 0.2 | 0.1 | 0.2 | 0.2 | 0.3 | 0.3 |
| Delay disc. indifference point, 24s delay | 0.0 | 0.0 | 0.1 | 0.1 | -0.1 | 0.1 | 0.2 | 0.2 | 0.2 |
| Weight adjusted by age | 0.0 | 0.0 | 0.0 | -0.1 | -0.1 | -0.1 | -0.2 | -0.0 | -0.1 |
| Locomotion in novel chamber post-restriction | 0.0 | 0.0 | 0.2 | 0.0 | -0.0 | 0.1 | 0.1 | 0.4 | 0.3 |
| Mg content in liver | 0.0 | 0.1 | 0.2 | -0.1 | 0.0 | -0.2 | -0.2 | -0.4 | -0.3 |
| Mn content in liver | 0.0 | 0.0 | 0.0 | 0.1 | 0.1 | 0.0 | -0.1 | -0.2 | -0.0 |
| Na content in liver | 0.0 | 0.0 | 0.0 | 0.1 | 0.0 | 0.1 | 0.1 | 0.0 | 0.1 |
| Se content in liver | 0.0 | 0.0 | 0.2 | -0.1 | -0.1 | 0.1 | 0.1 | 0.4 | 0.3 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.