Hub : Genes

Leo1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000010116	0.05	0.03	2.3e-04	0.02	0.02	0.03	0.01	1.4e-03	1.0e-03	9.6e-05	7.3e-03
2	Adipose	mRNA stability	ENSRNOG00000010116	0.04	0.03	1.1e-04	0.04	0.03	0.03	0.04	2.5e-05	1.5e-04	1.6e-04	8.1e-05
3	Brain	gene expression	ENSRNOG00000010116	0.04	0.03	3.5e-03	0.02	0.01	0	0.01	9.4e-03	5.1e-02	1.8e-01	7.8e-02
4	Brain	mRNA stability	ENSRNOG00000010116	0.09	0.05	2.9e-06	0.07	0.07	0.07	0.07	2.1e-07	2.6e-07	4.8e-07	4.0e-07
5	Liver	gene expression	ENSRNOG00000010116	0.03	0.02	5.9e-03	-0	-0	0	0	9.1e-01	6.0e-01	2.2e-01	1.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
BMI with tail	1.5	5.0	7.4	2.7	2.3	1.3	-2.3	-2.3
BMI without tail	0.9	1.8	2.5	1.3	1.6	0.6	-1.6	-1.5
Body weight	1.4	5.9	9.4	3.1	2.3	2.0	-2.3	-2.4
Epididymis fat weight	2.3	5.5	7.9	-1.4	-2.5	2.8	2.5	2.2
Glucose	0.3	0.5	1.3	-1.1	-0.7	0.0	0.7	0.7
Heart weight	0.2	0.3	1.2	-0.6	-0.1	1.1	0.1	-0.1
Left kidney weight	0.1	0.4	0.8	0.6	0.5	0.9	-0.5	-0.5
Right kidney weight	0.2	0.7	1.5	1.2	0.7	0.1	-0.7	-0.9
Tail length	0.2	0.6	1.0	0.7	1.0	-0.2	-1.0	-0.9
Length with tail	0.3	1.2	1.8	1.3	1.1	0.6	-1.1	-1.2
Length without tail	0.6	1.3	3.5	1.9	0.8	0.9	-0.8	-1.0
Liver weight, left	0.1	0.2	0.2	0.4	0.5	0.5	-0.5	-0.3
Liver weight, right	0.2	0.4	1.0	0.6	0.5	1.0	-0.5	-0.5
Parametrial fat weight	0.0	0.0	0.0	0.0	-0.0	0.1	0.0	0.1
Retroperitoneal fat weight	0.6	2.1	5.0	-0.5	-1.4	2.2	1.4	1.1
Intraocular pressure	0.1	0.2	0.6	-0.7	-0.1	0.7	0.1	0.2
Extensor digitorum longus weight	1.3	5.1	7.3	2.0	2.6	-0.7	-2.6	-2.7
Soleus weight	8.2	24.0	33.0	4.0	5.7	-2.3	-5.7	-5.7
Tibialis anterior weight	3.7	12.9	17.8	2.6	4.1	-2.4	-4.1	-4.2
Tibia length	0.4	1.1	3.6	1.9	0.4	1.2	-0.4	-0.5
Number of licking bursts	2.8	3.3	3.9	1.9	2.0	-1.2	-2.0	-2.0
Food consumed during 24 hour testing period	2.8	3.3	5.0	2.2	1.9	0.0	-1.9	-2.0
Times rat made contact with spout	0.8	1.0	1.3	1.1	1.1	0.0	-1.1	-1.1
Mean time between licks in bursts	0.2	0.2	0.3	0.3	-0.5	0.4	0.5	0.5
Mean num. licks in bursts	1.3	1.6	2.1	-1.1	-1.2	1.4	1.2	1.2
Std. dev. time between licks in bursts	2.0	2.4	3.6	1.9	1.5	-1.2	-1.5	-1.5
Water consumed over 24 hours	1.7	2.1	2.9	1.7	1.6	-0.2	-1.6	-1.6
Indifference point 0 sec	0.1	0.2	0.2	-0.4	0.3	-0.4	-0.3	-0.4
Indifference point AUC	0.3	0.4	0.8	0.6	-0.4	0.9	0.4	0.5
Indifference point function ln k	0.4	0.6	1.0	-0.7	0.7	-1.0	-0.7	-0.8
Indifference point function log k	0.4	0.6	1.0	-0.7	0.7	-1.0	-0.7	-0.8
Delay discounting total patch changes 0 sec	0.0	0.1	0.2	-0.4	0.1	-0.0	-0.1	-0.2
Delay discounting total patch changes 12 sec	0.4	0.5	0.7	0.1	-0.8	0.7	0.8	0.7
Delay discounting total patch changes 18 sec	0.3	0.4	0.6	-0.1	-0.7	0.6	0.7	0.7
Delay discounting total patch changes 24 sec	0.1	0.2	0.7	-0.8	0.0	0.3	-0.0	-0.0
Delay discounting total patch changes 6 sec	0.1	0.1	0.5	-0.7	0.0	-0.4	-0.0	0.1
Delay discounting time to switch 0 sec	0.3	0.4	0.5	-0.5	-0.7	-0.6	0.7	0.7
Delay discounting water rate 0 sec	0.4	0.7	1.2	0.2	1.0	0.4	-1.0	-1.1
Delay discounting water rate 12 sec	1.1	1.6	2.6	-0.3	1.6	-0.6	-1.6	-1.6
Delay discounting water rate 18 sec	0.6	0.8	2.3	-1.5	-0.5	1.1	0.5	0.3
Delay discounting water rate 24 sec	0.2	0.3	1.4	-1.2	0.0	-0.0	-0.0	-0.0
Delay discounting water rate 6 sec	1.4	2.0	3.1	0.4	1.8	-0.8	-1.8	-1.7
Locomotor activity	0.1	0.2	0.8	0.3	0.2	0.9	-0.2	-0.3
Locomotor testing distance	0.1	0.2	0.5	-0.6	0.0	0.7	-0.0	-0.0
Locomotor testing rearing	0.1	0.2	0.7	-0.8	-0.2	0.5	0.2	0.1
Light reinforcement 1	1.9	3.5	5.4	2.3	2.0	0.9	-2.0	-1.8
Light reinforcement 2	0.2	0.2	0.4	0.5	-0.5	0.0	0.5	0.6
Reaction time number correct	0.6	0.9	1.5	0.2	0.9	-1.2	-0.9	-1.0
Reaction time mean minus median	1.9	2.5	3.1	-1.3	-1.8	1.5	1.8	1.6
Reaction time mean minus median AUC	1.5	2.0	2.5	-1.4	-1.6	1.0	1.6	1.4
Reaction time num false alarms	1.0	1.4	2.6	-1.6	-1.3	-0.1	1.3	1.0
Reaction time num false alarms AUC	1.1	1.6	3.2	-1.8	-1.3	-0.2	1.3	1.0
Reaction time trials correct on left	0.6	0.9	1.5	0.2	0.9	-1.2	-0.9	-1.0
Reaction time trials on left	0.5	0.8	1.6	0.0	0.9	-1.3	-0.9	-0.9
Reaction time mean	1.5	2.0	2.9	-0.8	-1.7	1.2	1.7	1.5
Reaction time mean AUC	1.0	1.4	2.1	-0.7	-1.4	0.8	1.4	1.2
Median of all reaction times	1.3	1.7	2.7	-0.7	-1.6	1.0	1.6	1.3
Reaction time omissions	1.1	1.4	2.8	-1.7	-1.2	-0.0	1.2	1.2
Reaction time false alarm rate	1.7	2.4	3.5	-1.9	-1.7	0.6	1.7	1.5
Reaction time premature initiation rate	0.2	0.2	0.9	0.0	0.3	0.9	-0.3	-0.2
Reaction time premature initiations	0.2	0.3	0.4	0.0	0.7	0.3	-0.7	-0.6
Std. dev. reaction times	2.1	2.9	3.8	-1.5	-2.0	1.3	2.0	1.8
Reaction time trials completed	0.5	0.8	1.6	0.0	0.9	-1.3	-0.9	-0.9
Reaction time trials AUC	0.6	0.9	1.9	0.1	0.9	-1.4	-0.9	-1.0
Social response proportion	1.7	1.8	2.0	-1.4	-1.4	1.4	1.4	1.2
Social responses	0.1	0.1	0.5	0.4	0.0	0.7	-0.0	0.0
Social time	0.1	0.2	0.7	-0.9	-0.2	0.2	0.2	0.0
Conditioned locomotion	0.6	0.8	1.9	0.4	-0.8	1.4	0.8	0.7
Cocaine response after cond. corrected	0.7	0.8	1.4	0.5	1.1	0.0	-1.1	-1.2
Cocaine response after cond. not corrected	0.8	0.9	1.2	0.9	1.0	0.6	-1.0	-1.1
Cocaine response before conditioning	0.9	1.0	2.6	1.6	0.8	0.7	-0.8	-0.8
Saline control response	0.4	0.5	0.7	-0.9	-0.7	-0.8	0.7	0.6
Condit. Reinf. active minus inactive responses	0.5	0.7	0.9	-0.5	1.0	-0.6	-1.0	-1.0
Condit. Reinf. active-inactive response ratio	0.3	0.3	1.4	-1.2	0.1	-0.5	-0.1	-0.1
Condit. Reinf. active responses	0.9	1.3	2.1	0.7	1.4	0.1	-1.4	-1.5
Condit. Reinf. inactive responses	1.5	1.8	3.8	2.0	1.2	0.6	-1.2	-1.3
Condit. Reinf. lever presses	0.5	0.7	1.1	0.4	1.0	-0.6	-1.0	-1.1
Condit. Reinf. lever reinforcers received	0.6	0.9	1.5	0.5	1.2	0.3	-1.2	-1.2
Pavlov. Cond. lever latency	1.9	2.7	3.8	-1.1	-1.9	1.0	1.9	1.9
Pavlov. Cond. magazine entry latency	0.6	0.7	0.8	-0.7	-0.8	-0.9	0.8	0.8
Pavlov. Cond. change in total contacts	0.4	0.5	0.8	0.4	0.9	-0.2	-0.9	-0.8
Pavlov. Cond. index score	0.8	1.1	1.4	0.7	1.1	-1.2	-1.1	-1.1
Pavlov. Cond. latency score	1.0	1.3	1.8	0.7	1.2	-1.3	-1.2	-1.1
Pavlov. Cond. lever contacts	2.1	2.9	4.0	1.3	2.0	-0.9	-2.0	-1.9
Pavlov. Cond. magazine entry number	0.3	0.3	1.6	0.3	-0.1	1.3	0.1	0.1
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.4	1.2	0.4	0.3	-0.4	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.8	1.2	0.7	0.9	-1.1	-0.9	-0.9
Pavlov. Cond. response bias	0.8	1.1	1.5	0.7	1.2	-1.0	-1.2	-1.1
Conditioned reinforcement - actives	0.0	0.0	0.1	0.3	0.1	-0.1	-0.1	0.0
Conditioned reinforcement - inactives	0.2	0.2	0.5	-0.5	-0.3	0.7	0.3	0.2
Conditioned locomotion	1.2	1.5	1.7	-0.8	-1.3	1.3	1.3	1.3
Intermittent access intake day 1-15 change	0.2	0.2	0.7	0.5	0.1	0.8	-0.1	-0.4
Intermittent access intake escalation	0.7	0.7	1.1	1.0	0.8	0.5	-0.8	-1.0
Intermittent access intake escalation 2	1.7	1.7	2.7	1.7	1.3	-0.3	-1.3	-1.5
Intermitt. access day 1 inactive lever presses	0.3	0.3	0.8	-0.9	-0.6	-0.0	0.6	0.2
Intermitt. access day 15 inactive lever presses	0.8	0.9	1.6	0.1	-1.1	1.3	1.1	0.8
Intermitt. access escalation Index	1.3	1.2	3.1	0.7	0.9	1.8	-0.9	-0.9
Intermittent access day 1 total infusions	2.0	2.3	3.2	-1.2	-1.7	0.7	1.7	1.8
Intermittent access day 15 total infusions	0.4	0.4	0.8	-0.1	-0.7	0.9	0.7	0.5
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.4	0.2	-0.3	0.6	0.3	0.1
Intermittent access total infusions	0.8	0.8	1.3	-0.7	-1.1	0.4	1.1	1.0
Intermittent access day 1 locomotion	2.6	2.6	4.0	-1.2	-1.8	1.1	1.8	2.0
Intermittent access day 15 total locomotion	0.9	1.0	1.4	-0.9	-1.2	0.2	1.2	1.1
Intermittent access total locomotion	0.4	0.4	0.6	-0.7	-0.7	-0.3	0.7	0.6
Intermittent access standard deviation	0.2	0.2	0.7	0.9	-0.0	0.0	0.0	-0.4
Cocaine induced anxiety	0.2	0.2	0.9	-0.0	0.3	-1.0	-0.3	-0.2
Post-drug Anxiety	0.5	0.6	0.9	-0.9	-0.7	-1.0	0.7	0.5
Baseline Anxiety	1.5	1.6	2.1	-1.1	-1.4	0.9	1.4	1.3
Lifetime Intake	1.4	1.6	2.3	-1.0	-1.5	0.6	1.5	1.4
Incentive Sensitization - Responses	0.2	0.2	0.4	0.4	-0.4	0.6	0.4	0.4
Incentive Sensitization - Breakpoint	0.3	0.3	0.6	0.3	-0.5	0.8	0.5	0.6
Progressive ratio test 1 active lever presses	0.3	0.3	0.6	-0.2	-0.5	0.8	0.5	0.4
Progressive ratio test 1 breakpoint	0.2	0.2	0.3	-0.0	-0.6	0.6	0.6	0.5
Progressive ratio test 1 inactive lever presses	0.5	0.5	0.8	-0.4	-0.9	0.7	0.9	0.7
Progressive ratio test 2 active lever presses	0.2	0.3	0.5	-0.2	-0.5	0.7	0.5	0.5
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	-0.1	-0.4	0.5	0.4	0.3
Progressive ratio test 2 inactive lever presses	1.4	1.7	2.6	-0.8	-1.6	0.6	1.6	1.4
Total sessions with >9 infusions	0.0	0.0	0.1	0.2	-0.0	-0.3	0.0	0.0
Short access day 1 total inactive lever presses	0.4	0.5	1.0	-0.2	-0.7	1.0	0.7	0.5
Short access day 10 total inactive lever presses	0.3	0.3	0.8	-0.9	-0.6	0.0	0.6	0.1
Short access day 1 total infusions	0.4	0.5	0.8	0.4	-0.9	0.1	0.9	0.7
Short access day 10 total infusions	0.8	0.9	1.3	-0.7	-1.1	-0.4	1.1	1.0
Short access total infusions	2.9	3.1	4.5	-1.4	-2.1	0.8	2.1	2.0
Short access day 1 locomotion	0.3	0.3	0.4	0.7	0.6	-0.2	-0.6	-0.5
Short access day 10 total locomotion	0.3	0.3	1.2	0.5	0.3	-1.1	-0.3	-0.3
Short access total locomotion	0.3	0.3	0.5	-0.1	-0.7	-0.2	0.7	0.7
Compulsive drug intake	0.3	0.3	0.9	-0.9	-0.5	0.1	0.5	0.6
One hour access (0.3 mA shock)	0.5	0.5	0.7	-0.5	-0.8	0.5	0.8	0.9
One hour access (shock baseline)	0.1	0.1	0.3	0.5	-0.1	-0.3	0.1	0.0
Number of responses in last shaping day	1.8	1.8	3.4	1.9	1.3	-0.8	-1.3	-1.4
Context. condit. distance diff. score	0.2	0.3	0.4	0.2	0.5	-0.7	-0.5	-0.6
Locomotion velocity, session 1	0.4	0.4	0.7	0.5	0.7	0.1	-0.7	-0.8
Locomotion distance, session 1	0.1	0.1	0.4	0.2	0.1	-0.7	-0.1	-0.2
Locomotion velocity, session 2	1.2	1.4	2.1	0.9	1.5	-0.6	-1.5	-1.3
Locomotion distance, session 2	0.4	0.5	0.6	0.8	0.8	-0.2	-0.8	-0.8
Locomotion velocity, session 3	1.6	1.8	6.6	-0.3	0.9	-2.6	-0.9	-0.9
Locomotion distance, session 3	1.1	1.2	2.6	-1.6	-0.6	-1.5	0.6	0.6
Stereotopy head waving bouts, day 3	0.2	0.3	0.5	-0.4	-0.5	-0.7	0.5	0.5
Stereotopy head waving duration, day 3	0.1	0.1	0.2	-0.4	-0.4	-0.1	0.4	0.3
Locomotion velocity, session 7	0.1	0.2	0.6	-0.4	0.0	-0.8	-0.0	-0.1
Locomotion distance, session 7	0.4	0.5	1.1	0.3	0.6	-1.1	-0.6	-0.6
Stereotopy head waving bouts, day 7	1.1	1.2	4.2	-0.7	0.7	-2.0	-0.7	-0.7
Stereotopy head waving duration, day 7	1.2	1.4	3.8	-0.4	1.0	-2.0	-1.0	-1.0
Locomotion velocity, session 8	1.4	1.7	2.9	0.3	1.4	-1.7	-1.4	-1.4
Locomotion distance, session 8	1.2	1.9	2.7	0.9	1.4	-1.6	-1.4	-1.4
Degree of sensitization distance	1.0	1.0	2.9	1.7	0.8	0.6	-0.8	-0.8
Degree of sensitization stereotypy	1.1	1.2	3.4	-0.4	0.9	-1.8	-0.9	-0.9
Condit. Reinf. active minus inactive responses	0.6	0.7	1.1	0.4	1.1	0.1	-1.1	-1.0
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	-0.6	-0.1	0.6	0.1	-0.0
Condit. Reinf. active responses	2.1	2.6	3.9	1.1	2.0	-0.8	-2.0	-1.8
Condit. Reinf. inactive responses	2.4	2.8	3.6	1.5	1.9	-1.4	-1.9	-1.6
Incentive salience index mean	2.3	2.8	3.4	1.8	1.8	-0.7	-1.8	-1.8
Condit. Reinf. lever presses	3.6	4.8	9.7	3.1	2.0	-1.4	-2.0	-2.0
Time in familiar zone, hab. session 1	2.4	2.3	3.5	1.9	1.5	-1.1	-1.5	-1.5
Time in novel zone, hab. session 1	2.8	2.8	4.1	-2.0	-1.5	1.8	1.5	1.5
Total zone transitions, hab. session 1	0.1	0.2	0.2	-0.4	-0.4	-0.2	0.4	0.5
Total locomotion distance, hab. session 1	0.4	0.6	1.1	-1.0	-0.8	0.1	0.8	0.8
Locomotion velocity, hab. session 1	0.2	0.2	0.3	-0.6	-0.5	-0.2	0.5	0.5
Time in familiar zone, hab. session 2	0.1	0.1	0.2	-0.2	0.4	-0.4	-0.4	-0.3
Time in novel zone, hab. session 2	0.1	0.1	0.2	-0.2	-0.4	0.4	0.4	0.3
Total zone transitions, hab. session 2	0.2	0.3	0.5	0.7	0.6	-0.3	-0.6	-0.5
Total locomotion distance, hab. session 2	0.1	0.1	0.5	0.7	0.3	-0.0	-0.3	-0.2
Locomotion velocity, hab. session 2	0.1	0.1	0.5	0.7	0.0	0.1	-0.0	0.1
Novel to familiar place preference ratio	0.2	0.3	0.3	0.5	0.5	0.4	-0.5	-0.6
Novelty place preference	0.6	0.6	0.8	0.8	0.8	0.4	-0.8	-0.9
Time in novel zone, NPP test	0.7	0.7	1.0	0.7	0.9	0.4	-0.9	-1.0
Total zone transitions, NPP test	0.3	0.4	0.5	0.4	0.7	-0.7	-0.7	-0.6
Total locomotion distance, NPP test	0.4	0.5	0.7	0.7	0.8	-0.5	-0.8	-0.7
Locomotion velocity, NPP test	0.2	0.3	0.6	0.5	0.5	-0.8	-0.5	-0.4
Pavlov. Cond. lever latency	3.9	5.0	9.7	-3.1	-2.1	1.6	2.1	2.0
Pavlov. Cond. magazine entry latency	0.8	1.0	4.4	2.1	0.4	-0.2	-0.4	-0.4
Pavlov. Cond. change in total contacts	1.0	1.1	4.1	2.0	0.7	-0.3	-0.7	-0.7
Pavlov. Cond. index score	1.8	2.3	7.0	2.6	1.1	-0.9	-1.1	-1.1
Pavlov. Cond. latency score	1.9	2.4	6.7	2.6	1.2	-1.0	-1.2	-1.2
Pavlov. Cond. lever contacts	2.5	3.0	7.0	2.6	1.5	-1.1	-1.5	-1.5
Pavlov. Cond. magazine entry number	0.5	0.6	2.6	-1.6	-0.3	0.4	0.3	0.2
Pavlov. Cond. intertrial magazine entries	1.1	1.3	1.7	-0.9	1.2	-1.3	-1.2	-1.0
Pavlov. Cond. lever-magazine prob. diff.	2.1	2.7	7.9	2.8	1.2	-1.0	-1.2	-1.2
Pavlov. Cond. response bias	1.1	1.3	4.3	2.1	0.8	-0.5	-0.8	-0.7
Bone: apparent density	0.1	0.1	0.3	0.1	0.2	-0.6	-0.2	-0.2
Bone surface	2.1	3.7	4.3	1.6	2.1	-1.7	-2.1	-2.1
Bone volume	1.0	1.6	2.1	1.1	1.4	-0.9	-1.4	-1.5
Bone: connectivity density	0.2	0.4	1.4	-0.3	-0.3	-1.2	0.3	0.3
Bone: cortical apparent density	3.7	4.8	5.6	-2.4	-2.2	1.8	2.2	2.3
Bone: cortical area	0.0	0.0	0.0	-0.1	-0.2	0.1	0.2	0.2
Bone: cortical porosity	0.3	0.3	0.5	0.4	-0.6	0.3	0.6	0.7
Bone: cortical porosity	0.3	0.3	0.5	0.2	-0.7	-0.2	0.7	0.7
Bone: cortical thickness	2.6	4.3	5.3	-2.0	-2.3	1.3	2.3	2.3
Bone: cortical thickness	1.7	2.0	2.2	-1.2	-1.5	1.5	1.5	1.5
Bone: cortical tissue density	3.4	4.4	5.1	-2.3	-2.1	1.8	2.1	2.2
Bone: elastic displacement	0.5	0.5	1.3	-0.3	-0.6	1.1	0.6	0.7
Bone: elastic work	0.3	0.4	0.5	-0.5	-0.6	0.7	0.6	0.6
Bone: endosteal estimation	4.5	9.8	11.9	3.1	3.4	-2.0	-3.4	-3.4
Bone: endosteal perimeter	2.6	5.3	6.5	2.5	2.5	-1.3	-2.5	-2.6
Bone: final force	0.2	0.3	0.4	0.5	0.6	0.0	-0.6	-0.6
Bone: final moment	0.0	0.1	0.2	0.2	0.2	0.4	-0.2	-0.2
Bone: marrow area	4.4	9.5	11.4	3.2	3.3	-1.9	-3.3	-3.4
Bone: maximum diameter	4.0	7.4	9.6	2.8	3.0	-1.3	-3.0	-3.1
Bone: maximum force	0.6	1.0	1.3	1.1	1.1	-0.2	-1.1	-1.1
Bone: maximum moment	0.2	0.4	0.5	0.7	0.7	0.2	-0.7	-0.7
Bone: minimum diameter	0.1	0.2	0.5	0.6	0.1	0.7	-0.1	-0.1
Bone: periosteal estimation	2.2	4.5	5.8	2.1	2.4	-1.1	-2.4	-2.4
Bone: periosteal perimeter	1.1	1.9	2.4	1.0	1.5	-1.2	-1.5	-1.5
Bone: post-yield work	3.9	5.3	7.2	1.8	2.7	-1.4	-2.7	-2.6
Bone: stiffness	0.2	0.3	0.4	-0.1	0.6	-0.6	-0.6	-0.6
Bone: tissue strength	0.7	0.7	1.1	-1.1	-0.8	0.3	0.8	0.9
Bone: trabecular number	0.4	0.6	1.7	0.6	0.6	-1.3	-0.6	-0.6
Bone: trabecular spacing	2.3	3.0	3.2	-1.5	-1.8	1.7	1.8	1.8
Bone: trabecular thickness	0.2	0.2	0.7	-0.1	-0.4	0.8	0.4	0.3
Bone: trabecular tissue density	1.1	1.5	2.5	-1.0	-1.2	1.6	1.2	1.1
Breakpoint value in progressive ratio session	1.3	1.4	1.9	1.0	1.3	-0.9	-1.3	-1.4
Distance traveled before self-admin	1.5	1.7	3.6	0.6	1.2	-1.9	-1.2	-1.3
Distance traveled after self-admin	3.0	3.3	5.0	2.2	1.9	-0.8	-1.9	-1.8
Delta time in closed arm before/after self-admin	1.4	1.3	1.8	-0.4	-1.2	1.3	1.2	1.3
Delta time in open arm before/after self-admin	1.7	1.7	4.4	-2.1	-0.8	-1.3	0.8	0.8
Diff in mean of infusions in LGA sessions	2.0	2.2	3.6	1.4	1.5	-1.0	-1.5	-1.9
Extinction: sum of active levers before priming	0.2	0.2	0.8	0.0	-0.0	-0.9	0.0	0.0
Active lever presses in extinction session 6	0.8	0.7	0.9	0.2	1.0	-0.9	-1.0	-0.9
Delta distance traveled before/after self-admin	0.8	0.9	1.9	1.2	0.6	1.4	-0.6	-0.4
Delta ambulatory time before/after self-admin	0.6	0.7	1.7	1.1	0.5	1.3	-0.5	-0.3
Time in closed arm before self-admin	1.0	1.1	1.9	1.4	1.1	-0.5	-1.1	-1.0
Time in closed arm after self-admin	0.3	0.3	0.6	0.4	-0.5	0.8	0.5	0.6
Time in open arm before self-admin	0.6	0.6	0.8	0.9	0.9	-0.2	-0.9	-0.8
Time in open arm after self-admin	0.7	0.8	2.8	-0.7	0.5	-1.7	-0.5	-0.4
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	0.1	0.3	-0.3	-0.3	-0.4
Time to tail flick, vehicle, before self-admin	0.8	0.8	0.9	0.7	0.9	-0.9	-0.9	-0.9
Time to tail flick, vehicle, after self-admin	2.3	2.4	5.3	0.6	1.4	-2.3	-1.4	-1.6
Time to tail flick, test, before self-admin	0.1	0.1	0.1	0.2	0.3	0.2	-0.3	-0.3
Time to tail flick, test, after self-admin	0.8	0.8	1.5	0.7	0.9	-0.3	-0.9	-1.2
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.2	-0.1	0.7	-1.1	-0.7	-0.8
Delta time to tail flick, test, before/after SA	0.5	0.4	0.6	0.5	0.6	-0.7	-0.6	-0.8
Ambulatory time before self-admin	0.7	0.8	2.5	0.5	0.6	-1.6	-0.6	-0.7
Ambulatory time after self-admin	1.8	2.0	2.9	1.7	1.5	-0.7	-1.5	-1.4
Total heroin consumption	1.9	2.3	2.9	1.6	1.7	-0.7	-1.7	-1.6
Area under the delay curve	1.9	2.0	2.7	1.6	1.6	-0.2	-1.6	-1.5
Delay disc. indifference point, 0s delay	0.4	0.4	0.6	0.8	0.7	-0.3	-0.7	-0.7
Delay disc. indifference point, 16s delay	0.0	0.0	0.1	0.2	0.0	0.1	-0.0	-0.0
Delay disc. indifference point, 2s delay	0.5	0.5	0.7	0.9	0.8	0.4	-0.8	-0.8
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.2	0.4	0.0	-0.4	-0.2
Delay disc. indifference point, 4s delay	1.6	1.7	2.5	0.9	1.6	-0.7	-1.6	-1.5
Delay disc. indifference point, 8s delay	3.6	3.7	4.9	2.1	2.2	-0.4	-2.2	-2.2
Delay discount exponential model param	2.3	2.4	3.0	-1.7	-1.7	0.2	1.7	1.7
Delay discount hyperbolic model param	1.9	2.0	2.6	-1.5	-1.6	0.2	1.6	1.5
Fecal boli incidents, locomotor time 1	2.1	2.3	6.5	2.6	1.2	0.3	-1.2	-1.3
Change in fecal boli incidents, locomotor task	0.8	0.8	2.2	-1.3	0.0	-1.5	-0.0	0.1
Time >=10cm from walls, locomotor time 1	0.9	0.9	1.4	1.2	0.8	-0.7	-0.8	-1.0
Bouts of movement, locomotor time 1	0.4	0.5	1.2	1.1	0.6	0.2	-0.6	-0.6
Total resting periods, locomotor time 1	0.2	0.2	0.4	0.6	0.5	0.2	-0.5	-0.5
Rest time, locomotor task time 1	0.2	0.2	0.6	0.4	0.2	0.8	-0.2	-0.2
Distance moved, locomotor task time 1	0.4	0.5	1.7	-1.3	-0.5	-0.0	0.5	0.4
Vertical activity count, locomotor time 1	0.2	0.2	0.4	-0.6	-0.5	-0.2	0.5	0.1
Time >=10cm from walls, locomotor time 2	0.3	0.4	0.7	0.4	-0.6	0.8	0.6	0.5
Bouts of movement, locomotor time 2	0.3	0.3	0.9	0.4	-0.4	0.9	0.4	0.5
Total resting periods, locomotor time 2	0.2	0.2	0.6	0.3	-0.3	0.7	0.3	0.4
Rest time, locomotor task time 2	1.6	1.8	2.1	-1.2	-1.5	1.1	1.5	1.5
Distance moved, locomotor task time 2	0.4	0.4	0.6	0.1	0.8	-0.6	-0.8	-0.8
Vertical activity count, locomotor time 2	0.1	0.2	0.4	0.6	0.3	0.0	-0.3	-0.5
Weight adjusted by age	3.4	3.8	5.9	2.4	2.0	-1.1	-2.0	-1.9
Seeking ratio, delayed vs. immediate footshock	6.6	7.6	8.5	2.7	2.9	-2.3	-2.9	-2.8
Locomotion in novel chamber	0.2	0.3	0.5	-0.2	-0.6	0.1	0.6	0.7
Locomotion in novel chamber post-restriction	0.3	0.4	0.7	-0.1	-0.7	0.8	0.7	0.5
Progressive ratio	1.0	1.2	3.6	1.9	0.7	0.7	-0.7	-1.0
Food seeking constrained by brief footshock	3.1	3.8	6.0	0.8	2.4	-0.8	-2.4	-2.5
Seeking ratio, punishment vs. effort	0.8	1.0	1.3	-1.1	1.0	-1.1	-1.0	-0.7
Run reversals in cocaine runway, females	2.1	2.1	3.2	-1.8	-1.3	1.2	1.3	1.4
Run reversals in cocaine runway, males	1.7	1.6	2.2	0.8	1.4	-1.1	-1.4	-1.5
Latency to leave start box in cocaine runway	0.4	0.5	1.5	0.5	0.5	-1.2	-0.5	-0.5
Latency to leave start box in cocaine runway, F	0.5	0.5	1.0	1.0	0.7	-0.5	-0.7	-0.6
Latency to leave start box in cocaine runway, M	0.5	0.5	1.0	-0.7	-0.7	-1.0	0.7	0.4
Cd content in liver	0.4	0.4	0.6	0.6	0.8	-0.1	-0.8	-0.8
Co content in liver	0.7	0.9	3.7	0.3	-0.4	1.9	0.4	0.4
Cu content in liver	0.9	1.1	1.8	-0.6	-1.0	1.3	1.0	1.0
Fe content in liver	1.7	2.0	6.9	-0.1	1.0	-2.6	-1.0	-1.1
K content in liver	0.1	0.1	0.2	-0.3	0.1	-0.5	-0.1	-0.1
Mg content in liver	0.5	0.5	0.9	0.3	1.0	-0.0	-1.0	-0.9
Mn content in liver	0.5	0.5	0.9	0.1	-0.9	0.3	0.9	0.9
Na content in liver	0.9	1.0	3.3	0.6	0.6	-1.8	-0.6	-0.6
Rb content in liver	1.1	1.4	2.1	0.0	1.4	-1.0	-1.4	-1.4
Se content in liver	0.9	1.1	1.7	-0.7	-1.3	-0.2	1.3	1.2
Sr content in liver	1.0	0.9	2.5	1.6	0.8	-0.4	-0.8	-0.8
Zn content in liver	0.6	0.6	1.7	0.1	-0.7	1.3	0.7	0.7