Hub : Genes

Kcnmb2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000010094	0.04	0.04	8.8e-03	0	-0	-0	-0	3.0e-01	8.6e-01	9.0e-01	6.9e-01
2	NAcc	alternative polyA	ENSRNOT00000079254	0.03	0.02	5.6e-03	0.01	0.02	0	0.01	4.5e-02	2.3e-02	1.4e-01	2.5e-02
3	NAcc	alternative polyA	ENSRNOT00000083676	0.03	0.02	8.2e-03	0.01	0.01	-0	0.01	5.5e-02	3.3e-02	4.0e-01	3.6e-02
4	NAcc	gene expression	ENSRNOG00000010094	0.05	0.05	5.6e-03	0.03	0.02	0.02	0.02	1.4e-03	1.4e-02	2.2e-02	7.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
BMI with tail	0.9	3.0	3.9	-1.6	1.7	-1.7	-2.0
BMI without tail	1.5	3.1	4.1	-1.3	1.8	-1.8	-2.0
Body weight	0.3	1.2	3.5	-1.9	0.3	-0.2	-1.0
Epididymis fat weight	0.5	1.1	1.6	-1.3	-1.2	1.2	0.2
Glucose	1.3	2.0	3.0	-0.0	-1.7	1.7	1.4
Heart weight	0.3	0.5	0.7	0.3	0.8	-0.8	-0.6
Left kidney weight	0.1	0.3	0.4	-0.4	0.6	-0.6	-0.5
Right kidney weight	0.5	1.4	2.0	-1.1	1.2	-1.1	-1.4
Tail length	0.0	0.1	0.1	0.4	-0.1	0.1	0.3
Length with tail	0.2	0.7	0.9	0.0	-0.9	0.9	0.9
Length without tail	1.1	2.3	3.2	0.9	-1.7	1.6	1.8
Liver weight, left	1.1	1.8	4.5	-2.1	-1.1	1.2	-0.5
Liver weight, right	0.0	0.1	0.1	0.1	-0.3	0.3	0.3
Parametrial fat weight	0.2	0.3	0.9	-0.9	-0.1	0.2	-0.5
Retroperitoneal fat weight	0.1	0.4	0.7	-0.3	-0.8	0.8	0.3
Intraocular pressure	0.5	0.7	1.1	-0.0	-1.0	1.0	0.7
Extensor digitorum longus weight	0.2	0.9	1.5	-1.2	0.6	-0.6	-1.2
Soleus weight	6.4	18.7	31.1	1.4	5.5	-5.6	-3.4
Tibialis anterior weight	0.3	1.1	1.7	-0.7	1.1	-1.0	-1.3
Tibia length	3.2	8.9	11.6	1.0	-3.4	3.4	3.4
Number of licking bursts	1.9	2.3	3.0	-1.5	1.4	-1.3	-1.7
Food consumed during 24 hour testing period	0.1	0.1	0.3	-0.5	-0.0	0.0	-0.4
Times rat made contact with spout	0.7	0.8	1.4	-0.4	-1.2	1.2	0.6
Mean time between licks in bursts	1.8	2.6	4.6	1.4	-1.4	1.4	2.1
Mean num. licks in bursts	1.9	2.3	2.8	1.0	-1.7	1.6	1.6
Std. dev. time between licks in bursts	0.5	0.6	0.8	-0.2	-0.9	0.9	0.8
Water consumed over 24 hours	0.0	0.0	0.0	-0.0	-0.1	0.1	0.1
Indifference point 0 sec	0.5	0.8	1.4	-0.4	1.2	-1.2	-0.7
Indifference point AUC	3.5	4.1	6.2	-2.5	1.5	-1.4	-2.5
Indifference point function ln k	2.3	3.2	4.6	1.9	-1.6	1.5	2.1
Indifference point function log k	2.3	3.2	4.6	1.9	-1.6	1.5	2.1
Delay discounting total patch changes 0 sec	0.6	1.0	1.6	-0.5	1.3	-1.3	-0.8
Delay discounting total patch changes 12 sec	1.5	2.0	2.4	-1.3	1.4	-1.4	-1.5
Delay discounting total patch changes 18 sec	1.6	2.2	2.6	-1.6	1.4	-1.3	-1.6
Delay discounting total patch changes 24 sec	4.5	5.7	7.4	-1.0	2.7	-2.7	-2.6
Delay discounting total patch changes 6 sec	3.5	5.3	6.9	-1.4	2.6	-2.6	-2.4
Delay discounting time to switch 0 sec	0.1	0.2	0.5	0.7	-0.3	0.3	0.4
Delay discounting water rate 0 sec	0.2	0.3	0.5	-0.3	0.7	-0.7	-0.5
Delay discounting water rate 12 sec	0.2	0.2	0.5	0.7	-0.2	0.2	0.6
Delay discounting water rate 18 sec	0.3	0.4	1.0	-1.0	-0.5	0.5	0.0
Delay discounting water rate 24 sec	0.9	1.2	1.7	-0.4	1.3	-1.3	-1.1
Delay discounting water rate 6 sec	0.0	0.1	0.3	-0.5	0.0	-0.0	-0.1
Locomotor activity	1.9	3.0	4.1	0.9	-1.9	1.9	2.0
Locomotor testing distance	0.6	1.0	1.5	0.3	-1.2	1.2	1.1
Locomotor testing rearing	0.5	0.7	1.4	1.2	-0.5	0.4	1.0
Light reinforcement 1	1.1	2.1	3.9	2.0	-1.0	0.9	1.6
Light reinforcement 2	0.0	0.1	0.1	0.3	-0.2	0.3	0.3
Reaction time number correct	1.9	2.7	4.5	-2.1	-1.8	1.8	0.1
Reaction time mean minus median	0.1	0.1	0.5	-0.7	-0.1	0.1	-0.3
Reaction time mean minus median AUC	0.3	0.4	0.7	-0.8	0.5	-0.4	-0.8
Reaction time num false alarms	0.0	0.0	0.0	-0.2	0.2	-0.2	-0.2
Reaction time num false alarms AUC	0.0	0.1	0.2	-0.5	0.0	-0.0	-0.2
Reaction time trials correct on left	1.9	2.7	4.5	-2.1	-1.8	1.8	0.1
Reaction time trials on left	2.0	2.8	4.2	-2.1	-1.8	1.9	0.2
Reaction time mean	1.1	1.5	2.5	-0.2	-1.6	1.6	1.1
Reaction time mean AUC	0.9	1.3	1.9	0.1	-1.4	1.4	1.1
Median of all reaction times	1.1	1.5	2.3	-0.0	-1.5	1.5	1.2
Reaction time omissions	1.4	1.8	2.9	1.6	-1.0	0.9	1.7
Reaction time false alarm rate	0.5	0.7	1.1	0.7	1.0	-1.0	-0.3
Reaction time premature initiation rate	0.4	0.5	0.9	0.5	0.9	-0.9	-0.4
Reaction time premature initiations	0.1	0.2	0.5	-0.7	-0.2	0.3	-0.2
Std. dev. reaction times	0.1	0.1	0.3	-0.5	-0.4	0.4	0.0
Reaction time trials completed	2.0	2.8	4.2	-2.1	-1.8	1.9	0.2
Reaction time trials AUC	1.9	2.7	3.8	-2.0	-1.8	1.9	0.2
Social response proportion	2.3	2.5	3.8	0.3	-1.9	1.9	1.6
Social responses	0.0	0.0	0.1	-0.2	0.2	-0.2	-0.3
Social time	3.0	3.9	5.1	1.2	-2.2	2.1	2.3
Conditioned locomotion	0.6	0.7	2.3	1.5	-0.1	0.0	0.8
Cocaine response after cond. corrected	0.2	0.2	0.4	0.6	-0.2	0.1	0.5
Cocaine response after cond. not corrected	0.3	0.4	0.5	0.2	-0.7	0.7	0.7
Cocaine response before conditioning	0.0	0.0	0.1	-0.3	-0.2	0.2	-0.1
Saline control response	0.5	0.6	0.8	0.5	-0.9	0.9	0.8
Condit. Reinf. active minus inactive responses	1.0	1.2	2.0	-0.1	-1.4	1.4	0.9
Condit. Reinf. active-inactive response ratio	1.0	1.1	1.6	0.3	-1.3	1.2	1.1
Condit. Reinf. active responses	1.9	2.7	4.4	-0.9	-2.1	2.1	1.1
Condit. Reinf. inactive responses	1.2	1.6	2.5	-1.6	-1.3	1.4	0.3
Condit. Reinf. lever presses	0.3	0.4	0.5	-0.5	-0.7	0.7	0.4
Condit. Reinf. lever reinforcers received	1.8	2.6	4.2	-0.8	-2.0	2.0	1.1
Pavlov. Cond. lever latency	0.5	0.7	1.9	1.4	-0.3	0.3	0.8
Pavlov. Cond. magazine entry latency	0.4	0.5	1.5	-1.2	0.2	-0.1	-0.5
Pavlov. Cond. change in total contacts	0.7	1.0	2.3	-1.5	-0.9	1.0	0.1
Pavlov. Cond. index score	0.6	0.8	2.8	-1.7	0.2	-0.1	-0.7
Pavlov. Cond. latency score	0.7	0.9	3.1	-1.8	0.1	-0.0	-0.7
Pavlov. Cond. lever contacts	0.4	0.5	0.8	-0.9	0.6	-0.6	-0.7
Pavlov. Cond. magazine entry number	0.8	1.0	2.3	1.5	-0.6	0.6	1.0
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.2	0.5	-0.4	0.3	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	3.4	-1.8	0.1	-0.0	-0.7
Pavlov. Cond. response bias	0.3	0.4	0.9	-0.9	0.5	-0.5	-0.5
Conditioned reinforcement - actives	0.4	0.4	0.6	0.6	-0.7	0.7	0.8
Conditioned reinforcement - inactives	0.1	0.1	0.3	0.5	-0.2	0.2	0.5
Conditioned locomotion	0.2	0.2	0.4	-0.1	-0.6	0.6	0.5
Intermittent access intake day 1-15 change	0.3	0.3	0.5	0.3	0.7	-0.7	-0.3
Intermittent access intake escalation	0.2	0.2	0.4	0.0	0.6	-0.6	-0.3
Intermittent access intake escalation 2	0.1	0.1	0.2	-0.1	-0.4	0.4	0.5
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.4	0.5	-0.3	0.3	0.6
Intermitt. access day 15 inactive lever presses	0.5	0.6	1.0	0.0	-0.8	0.9	1.0
Intermitt. access escalation Index	0.0	0.0	0.0	-0.2	-0.0	0.0	-0.0
Intermittent access day 1 total infusions	2.2	2.5	4.0	-0.7	-2.0	2.0	1.2
Intermittent access day 15 total infusions	0.3	0.3	1.0	-1.0	-0.4	0.5	-0.1
Intermittent access terminal intake (last 3 days)	1.3	1.4	1.9	-1.3	-1.3	1.4	0.5
Intermittent access total infusions	1.1	1.2	1.7	-1.3	-1.2	1.3	0.4
Intermittent access day 1 locomotion	0.4	0.5	0.7	-0.5	-0.8	0.9	0.4
Intermittent access day 15 total locomotion	0.8	0.9	1.1	-0.5	1.1	-1.0	-1.0
Intermittent access total locomotion	0.4	0.4	1.3	-1.2	0.0	0.0	-0.5
Intermittent access standard deviation	0.1	0.1	0.2	0.5	0.2	-0.2	0.2
Cocaine induced anxiety	0.4	0.4	0.9	-1.0	-0.6	0.6	0.0
Post-drug Anxiety	0.9	1.0	1.6	-0.4	-1.2	1.3	0.8
Baseline Anxiety	0.2	0.2	0.5	0.7	0.4	-0.4	0.1
Lifetime Intake	1.5	1.6	2.4	-1.2	-1.5	1.5	0.7
Incentive Sensitization - Responses	0.9	0.8	2.0	-1.4	0.4	-0.3	-1.0
Incentive Sensitization - Breakpoint	0.8	0.8	2.2	-1.5	0.2	-0.2	-0.9
Progressive ratio test 1 active lever presses	1.0	1.0	1.6	-0.2	-1.2	1.2	0.9
Progressive ratio test 1 breakpoint	1.1	1.1	1.7	-0.2	-1.3	1.3	1.0
Progressive ratio test 1 inactive lever presses	0.8	0.8	1.2	0.1	-1.0	1.0	1.1
Progressive ratio test 2 active lever presses	0.6	0.7	2.0	-1.4	-0.5	0.6	-0.3
Progressive ratio test 2 breakpoint	0.5	0.6	1.9	-1.4	-0.2	0.3	-0.5
Progressive ratio test 2 inactive lever presses	0.4	0.5	1.0	-1.0	-0.7	0.7	0.2
Total sessions with >9 infusions	1.4	1.6	2.0	0.6	-1.4	1.4	1.4
Short access day 1 total inactive lever presses	0.6	0.7	1.2	-0.2	1.1	-1.1	-0.7
Short access day 10 total inactive lever presses	1.0	1.1	1.7	-0.1	1.3	-1.3	-1.0
Short access day 1 total infusions	0.5	0.6	0.8	-0.5	-0.9	0.9	0.6
Short access day 10 total infusions	1.0	1.1	1.7	-0.5	-1.3	1.3	0.8
Short access total infusions	1.4	1.6	2.5	-0.6	-1.5	1.6	1.0
Short access day 1 locomotion	0.8	0.9	1.2	-1.0	0.8	-0.8	-1.1
Short access day 10 total locomotion	0.4	0.5	0.7	-0.2	0.8	-0.8	-0.8
Short access total locomotion	0.2	0.2	0.6	-0.8	-0.4	0.5	-0.0
Compulsive drug intake	0.3	0.3	0.5	-0.0	-0.7	0.7	0.5
One hour access (0.3 mA shock)	0.4	0.5	0.7	-0.8	-0.8	0.8	0.2
One hour access (shock baseline)	0.8	0.9	1.9	-1.4	-0.9	1.0	0.1
Number of responses in last shaping day	1.9	1.9	3.4	-1.8	0.9	-0.9	-1.6
Context. condit. distance diff. score	2.9	3.6	5.4	1.1	2.3	-2.3	-1.6
Locomotion velocity, session 1	1.4	1.5	3.9	-2.0	-0.9	1.0	-0.2
Locomotion distance, session 1	1.0	1.3	4.5	-2.1	-0.3	0.4	-0.6
Locomotion velocity, session 2	2.2	2.6	5.6	-2.4	-1.5	1.6	-0.0
Locomotion distance, session 2	0.8	1.2	2.3	-1.5	-1.0	1.1	0.3
Locomotion velocity, session 3	0.3	0.3	1.0	-1.0	-0.0	0.0	-0.6
Locomotion distance, session 3	0.3	0.4	0.9	-1.0	-0.4	0.5	-0.2
Stereotopy head waving bouts, day 3	0.1	0.1	0.5	-0.7	-0.2	0.2	-0.2
Stereotopy head waving duration, day 3	0.8	1.0	1.4	-0.8	1.0	-1.0	-1.2
Locomotion velocity, session 7	0.7	0.8	1.1	0.4	-1.0	1.0	1.0
Locomotion distance, session 7	0.7	0.9	1.1	0.5	-1.0	1.0	1.1
Stereotopy head waving bouts, day 7	2.5	2.8	4.7	-1.6	1.5	-1.4	-2.2
Stereotopy head waving duration, day 7	2.1	2.6	4.1	-1.3	1.5	-1.5	-2.0
Locomotion velocity, session 8	1.6	1.9	2.8	-0.6	1.7	-1.6	-1.4
Locomotion distance, session 8	0.5	0.8	1.2	0.2	1.1	-1.1	-0.9
Degree of sensitization distance	1.6	1.6	2.4	1.3	-1.1	1.1	1.5
Degree of sensitization stereotypy	2.5	2.7	4.3	-1.1	1.7	-1.6	-2.1
Condit. Reinf. active minus inactive responses	1.3	1.5	2.2	-0.0	-1.5	1.5	1.2
Condit. Reinf. active-inactive response ratio	1.5	1.7	2.2	0.7	-1.4	1.4	1.5
Condit. Reinf. active responses	0.6	0.8	1.2	-0.4	-1.1	1.1	0.8
Condit. Reinf. inactive responses	0.2	0.2	0.5	-0.7	0.3	-0.3	-0.5
Incentive salience index mean	1.3	1.6	2.5	-0.4	-1.6	1.6	1.1
Condit. Reinf. lever presses	0.4	0.6	1.1	-1.0	-0.8	0.8	0.1
Time in familiar zone, hab. session 1	0.1	0.1	0.2	-0.4	-0.1	0.1	-0.2
Time in novel zone, hab. session 1	1.2	1.2	1.9	0.9	1.3	-1.4	-0.5
Total zone transitions, hab. session 1	0.5	0.6	0.8	-0.7	0.9	-0.8	-0.8
Total locomotion distance, hab. session 1	1.5	2.2	3.7	0.1	1.9	-1.9	-1.2
Locomotion velocity, hab. session 1	1.4	2.0	3.2	-0.1	1.8	-1.8	-1.2
Time in familiar zone, hab. session 2	0.1	0.1	0.3	0.5	-0.2	0.2	0.5
Time in novel zone, hab. session 2	0.8	0.8	1.2	0.3	1.1	-1.1	-0.8
Total zone transitions, hab. session 2	0.3	0.4	1.4	-1.2	-0.0	0.1	-0.3
Total locomotion distance, hab. session 2	0.3	0.4	0.6	-0.8	0.5	-0.5	-0.6
Locomotion velocity, hab. session 2	0.2	0.3	0.9	-0.9	0.3	-0.2	-0.5
Novel to familiar place preference ratio	5.5	5.8	9.2	1.1	3.0	-3.0	-2.0
Novelty place preference	7.0	7.2	11.5	1.2	3.3	-3.4	-2.2
Time in novel zone, NPP test	7.5	7.9	12.5	1.5	3.5	-3.5	-2.1
Total zone transitions, NPP test	1.2	1.7	4.5	-2.1	-1.0	1.1	-0.1
Total locomotion distance, NPP test	0.5	0.7	2.3	-1.5	-0.5	0.6	-0.0
Locomotion velocity, NPP test	0.7	1.0	2.6	-1.6	-0.8	0.9	0.1
Pavlov. Cond. lever latency	1.3	1.6	3.2	1.8	1.2	-1.3	0.2
Pavlov. Cond. magazine entry latency	0.2	0.2	0.5	-0.7	0.3	-0.3	-0.5
Pavlov. Cond. change in total contacts	0.7	0.8	2.5	-1.6	-0.4	0.5	-0.4
Pavlov. Cond. index score	1.4	1.8	5.8	-2.4	-0.3	0.4	-1.1
Pavlov. Cond. latency score	1.4	1.7	5.1	-2.3	-0.7	0.8	-0.8
Pavlov. Cond. lever contacts	1.2	1.4	3.0	-1.7	-1.1	1.2	-0.1
Pavlov. Cond. magazine entry number	1.8	2.2	5.3	2.3	-0.7	0.6	1.7
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.3	0.8	-0.7	0.7	1.2
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.6	5.0	-2.2	-0.1	0.2	-1.2
Pavlov. Cond. response bias	1.5	1.8	4.5	-2.1	0.5	-0.4	-1.5
Bone: apparent density	2.0	3.3	5.5	0.7	2.3	-2.4	-1.4
Bone surface	0.2	0.3	0.9	0.9	0.3	-0.3	0.4
Bone volume	0.3	0.6	1.6	1.3	0.4	-0.5	0.5
Bone: connectivity density	1.4	2.3	3.2	-0.3	1.8	-1.8	-1.6
Bone: cortical apparent density	0.1	0.1	0.4	0.6	0.1	-0.1	0.4
Bone: cortical area	0.8	1.2	3.2	1.8	-0.2	0.2	1.3
Bone: cortical porosity	0.0	0.0	0.2	0.4	0.1	-0.1	-0.1
Bone: cortical porosity	0.2	0.2	0.7	0.9	0.1	-0.1	0.2
Bone: cortical thickness	0.5	0.9	2.8	1.7	0.2	-0.3	0.8
Bone: cortical thickness	0.7	0.8	2.5	-1.6	-0.2	0.3	-0.8
Bone: cortical tissue density	0.1	0.1	0.3	0.5	0.1	-0.1	0.3
Bone: elastic displacement	0.6	0.7	1.6	1.2	-0.2	0.2	1.0
Bone: elastic work	2.4	3.1	5.5	2.0	-1.2	1.1	2.3
Bone: endosteal estimation	0.5	1.2	1.9	0.5	-1.1	1.1	1.4
Bone: endosteal perimeter	0.4	0.8	1.3	-0.2	-1.1	1.1	0.9
Bone: final force	0.4	0.7	1.1	0.7	-0.8	0.7	1.0
Bone: final moment	0.4	0.6	1.0	0.8	-0.6	0.6	1.0
Bone: marrow area	0.4	0.8	1.4	0.4	-1.0	0.9	1.2
Bone: maximum diameter	0.1	0.2	0.5	0.6	-0.2	0.2	0.7
Bone: maximum force	0.9	1.6	2.6	1.2	-1.1	1.0	1.6
Bone: maximum moment	0.9	1.6	2.8	1.3	-1.0	0.9	1.7
Bone: minimum diameter	1.8	3.3	5.7	1.8	-1.5	1.4	2.4
Bone: periosteal estimation	0.7	1.5	2.7	1.3	-0.9	0.8	1.6
Bone: periosteal perimeter	0.6	0.9	1.6	1.1	-0.7	0.7	1.3
Bone: post-yield work	1.2	1.6	2.5	-1.0	-1.5	1.6	0.7
Bone: stiffness	0.4	0.6	0.9	0.9	-0.6	0.6	0.9
Bone: tissue strength	4.5	4.3	10.3	3.2	-0.8	0.7	2.4
Bone: trabecular number	5.2	8.1	11.6	-0.5	3.4	-3.4	-3.0
Bone: trabecular spacing	4.1	5.2	6.8	0.8	-2.6	2.6	2.6
Bone: trabecular thickness	0.2	0.3	0.4	0.3	0.6	-0.7	-0.4
Bone: trabecular tissue density	0.6	0.9	1.4	0.5	-1.0	0.9	1.2
Breakpoint value in progressive ratio session	2.5	2.8	3.7	-0.7	1.9	-1.9	-1.8
Distance traveled before self-admin	1.2	1.2	2.0	0.3	1.4	-1.4	-0.9
Distance traveled after self-admin	0.2	0.2	0.3	0.0	0.6	-0.5	-0.3
Delta time in closed arm before/after self-admin	0.4	0.4	1.2	1.1	0.4	-0.4	-0.0
Delta time in open arm before/after self-admin	0.4	0.4	1.0	-1.0	-0.5	0.6	-0.0
Diff in mean of infusions in LGA sessions	0.2	0.2	0.3	0.3	0.5	-0.6	-0.3
Extinction: sum of active levers before priming	1.4	1.4	2.4	1.5	-0.7	0.7	1.4
Active lever presses in extinction session 6	0.1	0.1	0.1	0.4	0.2	-0.2	0.2
Delta distance traveled before/after self-admin	0.6	0.6	0.9	-0.3	-1.0	1.0	0.6
Delta ambulatory time before/after self-admin	0.2	0.2	0.4	-0.2	-0.6	0.6	0.4
Time in closed arm before self-admin	0.2	0.3	0.7	0.8	0.4	-0.4	-0.1
Time in closed arm after self-admin	1.1	1.1	4.1	2.0	0.1	-0.1	0.5
Time in open arm before self-admin	1.0	1.1	1.5	-0.5	1.2	-1.2	-1.2
Time in open arm after self-admin	1.0	1.1	3.1	-1.8	0.3	-0.3	-1.0
Sum of active levers in priming session hrs 5-6	1.9	1.8	2.5	-0.0	-1.6	1.6	1.5
Time to tail flick, vehicle, before self-admin	0.9	0.9	1.4	0.2	-1.2	1.2	0.9
Time to tail flick, vehicle, after self-admin	1.5	1.6	2.4	-0.1	-1.5	1.5	1.3
Time to tail flick, test, before self-admin	1.5	1.5	2.3	1.5	1.3	-1.3	-0.6
Time to tail flick, test, after self-admin	2.6	2.6	3.8	0.3	1.9	-1.9	-1.7
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	0.9	-0.3	-0.9	1.0	1.0
Delta time to tail flick, test, before/after SA	2.6	2.3	3.4	-1.5	1.4	-1.3	-1.8
Ambulatory time before self-admin	0.8	0.8	1.2	0.9	1.1	-1.1	-0.5
Ambulatory time after self-admin	0.1	0.1	0.3	0.5	0.4	-0.4	-0.1
Total heroin consumption	3.9	4.7	7.2	0.2	2.7	-2.7	-2.1
Area under the delay curve	1.3	1.4	1.7	-0.7	1.3	-1.3	-1.3
Delay disc. indifference point, 0s delay	0.4	0.5	1.5	-1.2	-0.4	0.5	0.1
Delay disc. indifference point, 16s delay	1.1	1.1	1.8	0.3	1.3	-1.3	-1.0
Delay disc. indifference point, 2s delay	0.5	0.6	0.9	-0.3	0.9	-0.9	-0.8
Delay disc. indifference point, 24s delay	1.1	1.0	1.3	1.1	1.1	-1.2	-0.6
Delay disc. indifference point, 4s delay	0.8	0.8	1.6	-1.3	0.7	-0.7	-0.9
Delay disc. indifference point, 8s delay	0.7	0.7	1.4	-1.2	0.6	-0.6	-0.8
Delay discount exponential model param	1.5	1.6	2.0	0.7	-1.4	1.4	1.4
Delay discount hyperbolic model param	1.1	1.2	1.5	0.7	-1.2	1.2	1.2
Fecal boli incidents, locomotor time 1	1.1	1.2	1.8	-0.2	-1.4	1.3	1.1
Change in fecal boli incidents, locomotor task	0.5	0.4	0.6	0.0	0.8	-0.8	-0.8
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	0.4	-0.2	0.2	0.1
Bouts of movement, locomotor time 1	0.2	0.3	0.8	0.9	-0.2	0.2	0.4
Total resting periods, locomotor time 1	0.2	0.2	0.4	0.6	-0.3	0.3	0.4
Rest time, locomotor task time 1	1.0	1.1	2.3	-1.5	-1.0	1.0	0.3
Distance moved, locomotor task time 1	1.0	1.1	1.5	-0.4	1.2	-1.1	-1.2
Vertical activity count, locomotor time 1	0.8	0.9	1.3	0.1	1.1	-1.1	-1.0
Time >=10cm from walls, locomotor time 2	0.6	0.6	1.8	-1.3	-0.5	0.5	-0.2
Bouts of movement, locomotor time 2	0.1	0.1	0.1	-0.3	0.3	-0.3	-0.3
Total resting periods, locomotor time 2	0.0	0.1	0.1	-0.3	0.2	-0.2	-0.2
Rest time, locomotor task time 2	0.0	0.0	0.0	-0.2	0.1	-0.1	-0.1
Distance moved, locomotor task time 2	0.4	0.4	1.2	-1.1	0.2	-0.1	-0.7
Vertical activity count, locomotor time 2	0.8	0.9	2.5	-1.6	-0.6	0.7	-0.2
Weight adjusted by age	2.0	2.2	3.1	1.0	-1.6	1.5	1.8
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	0.9	0.9	0.9	-1.0	-0.7
Locomotion in novel chamber	1.1	1.3	4.8	-2.2	-0.3	0.4	-0.5
Locomotion in novel chamber post-restriction	0.3	0.3	0.9	0.9	0.4	-0.4	-0.1
Progressive ratio	0.1	0.1	0.1	-0.3	-0.3	0.3	0.1
Food seeking constrained by brief footshock	0.4	0.5	1.6	1.3	0.5	-0.5	0.1
Seeking ratio, punishment vs. effort	0.6	0.7	1.4	1.2	0.9	-0.9	-0.1
Run reversals in cocaine runway, females	0.1	0.1	0.3	0.5	0.3	-0.3	0.2
Run reversals in cocaine runway, males	0.2	0.2	0.3	-0.2	-0.5	0.6	0.4
Latency to leave start box in cocaine runway	0.1	0.1	0.4	-0.6	-0.2	0.2	-0.2
Latency to leave start box in cocaine runway, F	0.3	0.4	1.1	-1.1	-0.2	0.2	-0.4
Latency to leave start box in cocaine runway, M	0.2	0.2	0.7	0.8	-0.0	0.0	0.3
Cd content in liver	0.9	1.0	1.7	-0.1	-1.3	1.3	0.7
Co content in liver	0.8	0.9	2.7	-1.7	-0.5	0.5	-0.7
Cu content in liver	0.3	0.4	0.5	0.3	-0.7	0.7	0.7
Fe content in liver	0.7	0.9	1.4	1.0	-0.8	0.8	1.2
K content in liver	0.7	0.7	1.5	1.2	0.8	-0.9	0.2
Mg content in liver	0.8	0.8	2.6	1.6	0.3	-0.4	0.6
Mn content in liver	0.8	0.9	3.0	1.7	0.1	-0.2	0.8
Na content in liver	1.5	1.6	2.1	-0.5	1.5	-1.4	-1.4
Rb content in liver	0.6	0.7	1.9	1.4	0.7	-0.7	0.2
Se content in liver	0.5	0.6	1.1	-0.3	-1.0	1.0	0.5
Sr content in liver	1.1	1.0	2.1	-1.4	0.5	-0.4	-1.2
Zn content in liver	0.5	0.6	1.2	1.0	-0.3	0.2	1.1