Hub : Genes

Kcnk3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000009790	0.06	0.06	1.9e-06	0.05	0.05	0.03	0.04	7.6e-06	3.1e-06	5.3e-04	9.2e-06
2	Liver	gene expression	ENSRNOG00000009790	0.03	0.03	5.9e-03	0.01	0.01	0.01	0.01	3.2e-02	6.4e-02	3.0e-02	6.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	2.4	7.7	9.1	2.5	-3.0
BMI without tail	0.4	0.9	1.1	0.8	-1.1
Body weight	2.3	9.5	9.6	3.1	-3.1
Epididymis fat weight	16.5	38.4	38.5	6.2	-6.2
Glucose	0.2	0.4	0.4	0.6	-0.6
Heart weight	5.4	7.7	9.6	3.1	-2.4
Left kidney weight	0.4	1.0	1.5	-0.7	1.2
Right kidney weight	0.2	0.6	1.1	1.0	-0.3
Tail length	0.1	0.3	0.4	-0.4	0.6
Length with tail	0.2	0.8	1.4	1.2	-0.6
Length without tail	0.2	0.5	0.7	0.8	-0.5
Liver weight, left	1.2	1.9	2.2	1.5	-1.3
Liver weight, right	6.8	11.3	13.0	3.6	-3.1
Parametrial fat weight	9.6	18.8	19.0	4.3	-4.4
Retroperitoneal fat weight	29.7	98.2	99.4	9.8	-10.0
Intraocular pressure	5.0	7.0	8.1	2.8	-2.4
Extensor digitorum longus weight	2.6	10.2	11.9	-3.4	2.9
Soleus weight	3.0	8.7	9.4	-3.1	2.9
Tibialis anterior weight	1.1	3.9	5.2	-2.3	1.6
Tibia length	1.0	2.8	3.6	1.9	-1.4
Number of licking bursts	1.1	1.3	1.7	1.0	-1.3
Food consumed during 24 hour testing period	0.1	0.1	0.1	0.1	-0.4
Times rat made contact with spout	0.6	0.7	1.0	-1.0	0.7
Mean time between licks in bursts	2.2	3.0	3.4	1.8	-1.6
Mean num. licks in bursts	1.4	1.7	2.0	-1.2	1.4
Std. dev. time between licks in bursts	0.9	1.1	1.2	1.0	-1.1
Water consumed over 24 hours	0.1	0.1	0.1	-0.4	0.0
Indifference point 0 sec	0.7	1.1	1.3	0.9	-1.1
Indifference point AUC	0.1	0.2	0.3	-0.5	-0.2
Indifference point function ln k	1.2	1.8	2.5	-1.0	1.6
Indifference point function log k	1.2	1.8	2.5	-1.0	1.6
Delay discounting total patch changes 0 sec	0.7	1.1	1.3	0.9	-1.2
Delay discounting total patch changes 12 sec	1.3	1.7	2.0	1.2	-1.4
Delay discounting total patch changes 18 sec	0.8	1.1	1.5	0.8	-1.2
Delay discounting total patch changes 24 sec	1.3	1.6	1.7	1.2	-1.3
Delay discounting total patch changes 6 sec	1.7	2.6	3.8	1.2	-1.9
Delay discounting time to switch 0 sec	0.2	0.3	0.4	0.4	-0.6
Delay discounting water rate 0 sec	0.8	1.2	1.6	-1.0	1.3
Delay discounting water rate 12 sec	0.2	0.3	0.5	0.7	-0.2
Delay discounting water rate 18 sec	0.6	0.8	1.4	-0.6	1.2
Delay discounting water rate 24 sec	0.3	0.3	0.6	0.8	-0.3
Delay discounting water rate 6 sec	0.1	0.1	0.1	0.2	0.3
Locomotor activity	0.6	0.9	0.9	0.9	-0.9
Locomotor testing distance	0.2	0.3	0.4	0.4	-0.7
Locomotor testing rearing	0.5	0.8	1.1	-1.1	0.7
Light reinforcement 1	0.8	1.4	2.1	-1.5	0.8
Light reinforcement 2	1.2	1.6	2.1	-1.4	1.1
Reaction time number correct	0.2	0.3	0.4	-0.6	0.6
Reaction time mean minus median	0.0	0.0	0.0	-0.1	-0.0
Reaction time mean minus median AUC	0.0	0.0	0.0	0.2	-0.2
Reaction time num false alarms	1.5	2.1	2.9	1.2	-1.7
Reaction time num false alarms AUC	1.5	2.2	2.9	1.2	-1.7
Reaction time trials correct on left	0.2	0.3	0.4	-0.6	0.6
Reaction time trials on left	0.2	0.3	0.4	-0.6	0.6
Reaction time mean	0.1	0.2	0.3	0.6	-0.3
Reaction time mean AUC	0.1	0.1	0.2	0.4	-0.1
Median of all reaction times	0.1	0.1	0.3	0.5	-0.1
Reaction time omissions	0.0	0.1	0.1	0.2	-0.3
Reaction time false alarm rate	2.1	3.0	3.8	1.5	-2.0
Reaction time premature initiation rate	0.2	0.2	0.2	0.5	-0.5
Reaction time premature initiations	0.0	0.0	0.0	0.1	-0.1
Std. dev. reaction times	0.2	0.2	0.3	0.5	-0.5
Reaction time trials completed	0.2	0.3	0.4	-0.6	0.6
Reaction time trials AUC	0.3	0.4	0.5	-0.7	0.6
Social response proportion	0.2	0.2	0.3	-0.1	0.6
Social responses	0.1	0.1	0.1	0.3	-0.3
Social time	0.1	0.1	0.2	-0.1	0.5
Conditioned locomotion	3.9	4.6	4.7	-2.2	2.1
Cocaine response after cond. corrected	0.2	0.3	0.3	-0.5	0.5
Cocaine response after cond. not corrected	0.9	1.0	1.0	-1.0	1.0
Cocaine response before conditioning	2.2	2.7	2.7	-1.6	1.6
Saline control response	1.4	1.8	2.0	-1.3	1.4
Condit. Reinf. active minus inactive responses	1.8	2.2	3.0	-1.7	1.2
Condit. Reinf. active-inactive response ratio	0.8	0.8	0.9	-1.0	0.9
Condit. Reinf. active responses	1.1	1.6	2.3	-1.5	0.9
Condit. Reinf. inactive responses	0.3	0.4	0.8	-0.9	0.3
Condit. Reinf. lever presses	1.2	1.6	2.0	-1.4	1.2
Condit. Reinf. lever reinforcers received	1.0	1.4	2.1	-1.4	0.8
Pavlov. Cond. lever latency	1.0	1.3	1.6	1.3	-1.0
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	-0.1	-0.1
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.4	0.1
Pavlov. Cond. index score	0.4	0.5	0.7	-0.8	0.6
Pavlov. Cond. latency score	0.4	0.5	0.7	-0.8	0.6
Pavlov. Cond. lever contacts	0.3	0.4	0.5	-0.7	0.5
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	-0.1	0.4
Pavlov. Cond. intertrial magazine entries	2.7	3.5	3.9	2.0	-1.8
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.3	-0.5	0.2
Pavlov. Cond. response bias	0.5	0.7	0.9	-1.0	0.7
Conditioned reinforcement - actives	4.5	4.4	5.0	-2.0	2.2
Conditioned reinforcement - inactives	5.2	5.8	6.2	-2.3	2.5
Conditioned locomotion	3.5	4.2	4.8	-1.9	2.2
Intermittent access intake day 1-15 change	1.6	1.6	2.1	-1.1	1.5
Intermittent access intake escalation	0.9	0.9	1.3	-0.7	1.1
Intermittent access intake escalation 2	0.1	0.1	0.1	0.4	-0.1
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.1	-0.2	0.2
Intermitt. access day 15 inactive lever presses	2.5	2.8	4.0	-2.0	1.2
Intermitt. access escalation Index	2.2	2.0	2.3	1.3	-1.5
Intermittent access day 1 total infusions	4.3	4.9	5.6	-2.4	2.0
Intermittent access day 15 total infusions	4.3	4.8	5.1	-2.1	2.2
Intermittent access terminal intake (last 3 days)	3.6	3.9	3.9	-2.0	2.0
Intermittent access total infusions	5.0	5.6	5.8	-2.3	2.4
Intermittent access day 1 locomotion	2.4	2.4	2.6	-1.6	1.5
Intermittent access day 15 total locomotion	0.6	0.7	0.7	-0.8	0.8
Intermittent access total locomotion	1.0	1.2	1.3	-1.0	1.1
Intermittent access standard deviation	0.7	0.7	0.8	-0.8	0.9
Cocaine induced anxiety	0.1	0.1	0.1	-0.4	0.2
Post-drug Anxiety	1.5	1.7	1.8	1.3	-1.2
Baseline Anxiety	1.6	1.7	2.0	1.4	-1.2
Lifetime Intake	6.0	6.7	6.8	-2.6	2.6
Incentive Sensitization - Responses	0.8	0.8	1.2	-0.7	1.1
Incentive Sensitization - Breakpoint	0.5	0.5	0.7	-0.5	0.8
Progressive ratio test 1 active lever presses	3.4	3.6	3.7	-1.8	1.9
Progressive ratio test 1 breakpoint	2.8	2.8	2.9	-1.7	1.7
Progressive ratio test 1 inactive lever presses	6.3	6.8	6.8	-2.6	2.6
Progressive ratio test 2 active lever presses	2.0	2.1	2.6	-1.2	1.6
Progressive ratio test 2 breakpoint	2.0	2.2	2.8	-1.3	1.7
Progressive ratio test 2 inactive lever presses	3.3	3.8	3.8	-1.9	1.9
Total sessions with >9 infusions	7.2	7.9	8.2	-2.7	2.9
Short access day 1 total inactive lever presses	3.9	4.3	4.4	-2.1	2.1
Short access day 10 total inactive lever presses	0.0	0.0	0.1	-0.2	-0.2
Short access day 1 total infusions	6.0	6.3	6.9	-2.6	2.4
Short access day 10 total infusions	6.7	7.4	7.5	-2.7	2.7
Short access total infusions	5.8	6.4	6.4	-2.5	2.5
Short access day 1 locomotion	7.2	7.7	8.6	-2.9	2.6
Short access day 10 total locomotion	1.3	1.4	1.4	-1.2	1.2
Short access total locomotion	2.4	2.4	2.6	-1.5	1.6
Compulsive drug intake	2.9	2.9	3.0	1.6	-1.7
One hour access (0.3 mA shock)	2.5	2.9	3.0	-1.7	1.7
One hour access (shock baseline)	5.7	6.6	7.1	-2.5	2.7
Number of responses in last shaping day	2.2	2.2	2.3	-1.5	1.5
Context. condit. distance diff. score	0.1	0.2	0.3	-0.3	0.5
Locomotion velocity, session 1	0.6	0.6	0.7	0.7	-0.8
Locomotion distance, session 1	0.4	0.5	0.6	-0.8	0.6
Locomotion velocity, session 2	0.0	0.1	0.1	0.3	-0.1
Locomotion distance, session 2	0.1	0.1	0.1	0.3	-0.3
Locomotion velocity, session 3	0.1	0.1	0.3	-0.5	0.2
Locomotion distance, session 3	0.0	0.0	0.0	-0.2	-0.2
Stereotopy head waving bouts, day 3	2.2	2.6	2.9	-1.7	1.5
Stereotopy head waving duration, day 3	0.6	0.7	0.7	-0.8	0.8
Locomotion velocity, session 7	0.0	0.1	0.1	-0.3	-0.2
Locomotion distance, session 7	0.7	0.9	1.2	0.7	-1.1
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	0.0	-0.0
Stereotopy head waving duration, day 7	0.5	0.6	0.6	-0.8	0.7
Locomotion velocity, session 8	0.6	0.7	0.8	-0.8	0.9
Locomotion distance, session 8	0.3	0.4	0.5	-0.6	0.7
Degree of sensitization distance	1.0	1.0	1.0	1.0	-1.0
Degree of sensitization stereotypy	0.3	0.3	0.3	0.6	-0.5
Condit. Reinf. active minus inactive responses	1.7	1.9	2.0	1.3	-1.4
Condit. Reinf. active-inactive response ratio	1.4	1.5	1.6	1.2	-1.3
Condit. Reinf. active responses	0.1	0.1	0.1	0.2	-0.3
Condit. Reinf. inactive responses	1.1	1.3	1.3	-1.1	1.1
Incentive salience index mean	0.1	0.1	0.2	0.3	-0.4
Condit. Reinf. lever presses	0.5	0.7	0.8	-0.8	0.9
Time in familiar zone, hab. session 1	0.8	0.7	0.8	0.9	-0.8
Time in novel zone, hab. session 1	0.2	0.2	0.3	0.5	-0.5
Total zone transitions, hab. session 1	0.1	0.2	0.3	-0.4	0.5
Total locomotion distance, hab. session 1	0.6	0.9	1.1	-0.8	1.0
Locomotion velocity, hab. session 1	1.3	1.9	2.1	-1.3	1.4
Time in familiar zone, hab. session 2	0.2	0.3	0.3	0.4	-0.6
Time in novel zone, hab. session 2	0.0	0.0	0.1	0.3	-0.1
Total zone transitions, hab. session 2	0.1	0.2	0.2	0.3	-0.4
Total locomotion distance, hab. session 2	0.1	0.2	0.3	0.3	-0.5
Locomotion velocity, hab. session 2	0.1	0.1	0.1	0.1	-0.4
Novel to familiar place preference ratio	0.6	0.7	0.8	0.9	-0.8
Novelty place preference	1.1	1.1	1.3	1.1	-1.0
Time in novel zone, NPP test	1.0	1.1	1.2	1.1	-0.9
Total zone transitions, NPP test	0.9	1.3	1.4	-1.2	1.1
Total locomotion distance, NPP test	1.3	1.9	2.1	-1.4	1.3
Locomotion velocity, NPP test	1.9	2.6	3.0	-1.7	1.5
Pavlov. Cond. lever latency	0.6	0.7	0.9	0.9	-0.8
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.1	-0.2
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	-0.1	0.2
Pavlov. Cond. index score	0.1	0.1	0.1	-0.4	0.2
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.3	0.1
Pavlov. Cond. lever contacts	0.4	0.5	0.5	-0.7	0.7
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	0.2	-0.0
Pavlov. Cond. intertrial magazine entries	2.1	2.6	2.7	-1.6	1.6
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	0.7	-0.8	0.7
Pavlov. Cond. response bias	1.0	1.2	1.3	-1.1	1.1
Bone: apparent density	3.3	5.4	6.0	-2.4	2.2
Bone surface	0.7	1.2	1.6	-1.3	0.9
Bone volume	1.5	2.6	3.0	-1.7	1.5
Bone: connectivity density	2.3	3.6	4.2	-2.0	1.7
Bone: cortical apparent density	0.0	0.1	0.1	-0.3	0.2
Bone: cortical area	0.0	0.1	0.1	0.1	-0.3
Bone: cortical porosity	3.2	3.5	3.5	-1.9	1.9
Bone: cortical porosity	2.5	2.7	2.7	-1.6	1.7
Bone: cortical thickness	0.3	0.5	0.5	0.7	-0.7
Bone: cortical thickness	0.5	0.6	0.7	-0.9	0.6
Bone: cortical tissue density	0.0	0.0	0.0	-0.2	0.1
Bone: elastic displacement	1.6	1.8	1.8	-1.3	1.4
Bone: elastic work	0.5	0.7	0.9	-0.9	0.7
Bone: endosteal estimation	0.1	0.2	0.3	-0.5	0.2
Bone: endosteal perimeter	0.0	0.0	0.0	-0.1	-0.2
Bone: final force	0.0	0.0	0.0	0.0	-0.2
Bone: final moment	0.0	0.0	0.0	-0.0	-0.2
Bone: marrow area	0.1	0.2	0.3	-0.6	0.3
Bone: maximum diameter	0.0	0.1	0.1	-0.3	-0.1
Bone: maximum force	0.0	0.0	0.1	0.1	-0.3
Bone: maximum moment	0.0	0.0	0.0	0.0	-0.2
Bone: minimum diameter	0.5	0.8	1.0	0.8	-1.0
Bone: periosteal estimation	0.1	0.2	0.3	-0.5	0.3
Bone: periosteal perimeter	0.0	0.0	0.1	0.0	-0.3
Bone: post-yield work	1.8	2.4	2.7	-1.5	1.6
Bone: stiffness	0.1	0.2	0.2	0.4	-0.5
Bone: tissue strength	0.5	0.5	0.7	0.8	-0.6
Bone: trabecular number	3.2	5.0	5.3	-2.3	2.2
Bone: trabecular spacing	1.1	1.5	2.0	1.4	-1.0
Bone: trabecular thickness	0.4	0.5	0.6	-0.8	0.6
Bone: trabecular tissue density	0.2	0.3	0.3	-0.5	0.5
Breakpoint value in progressive ratio session	1.0	1.1	1.4	-1.2	0.9
Distance traveled before self-admin	0.2	0.2	0.3	-0.3	0.6
Distance traveled after self-admin	0.3	0.3	0.6	0.7	-0.4
Delta time in closed arm before/after self-admin	0.5	0.4	0.6	0.5	-0.8
Delta time in open arm before/after self-admin	0.2	0.1	0.2	-0.4	0.4
Diff in mean of infusions in LGA sessions	0.1	0.1	0.1	-0.3	0.1
Extinction: sum of active levers before priming	0.4	0.4	0.4	-0.7	0.6
Active lever presses in extinction session 6	1.6	1.5	1.6	-1.3	1.2
Delta distance traveled before/after self-admin	2.1	2.2	2.3	1.4	-1.5
Delta ambulatory time before/after self-admin	0.5	0.6	0.7	0.7	-0.8
Time in closed arm before self-admin	0.1	0.2	0.2	0.5	-0.3
Time in closed arm after self-admin	0.8	0.8	0.9	0.9	-0.9
Time in open arm before self-admin	0.1	0.1	0.1	0.2	-0.3
Time in open arm after self-admin	0.5	0.5	0.6	-0.8	0.7
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	0.1	-0.6
Time to tail flick, vehicle, before self-admin	1.0	1.0	1.1	1.0	-0.9
Time to tail flick, vehicle, after self-admin	5.0	5.4	5.6	2.4	-2.3
Time to tail flick, test, before self-admin	0.9	0.9	1.0	-1.0	0.9
Time to tail flick, test, after self-admin	0.6	0.7	1.0	-0.6	1.0
Delta time to tail flick, vehicle, before/after SA	1.2	1.1	1.4	0.9	-1.2
Delta time to tail flick, test, before/after SA	1.5	1.4	1.7	-1.0	1.3
Ambulatory time before self-admin	0.2	0.2	0.3	-0.3	0.6
Ambulatory time after self-admin	0.1	0.2	0.3	0.5	-0.2
Total heroin consumption	1.4	1.7	2.1	-1.5	1.2
Area under the delay curve	0.1	0.1	0.1	0.2	-0.3
Delay disc. indifference point, 0s delay	1.9	2.1	2.6	1.6	-1.3
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	0.2	-0.4
Delay disc. indifference point, 2s delay	0.2	0.3	0.3	0.5	-0.5
Delay disc. indifference point, 24s delay	2.3	2.2	2.6	-1.3	1.6
Delay disc. indifference point, 4s delay	0.2	0.3	0.3	0.5	-0.5
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	-0.1	0.1
Delay discount exponential model param	0.0	0.0	0.0	0.0	0.0
Delay discount hyperbolic model param	0.0	0.0	0.0	-0.0	0.1
Fecal boli incidents, locomotor time 1	2.4	2.6	3.1	-1.4	1.8
Change in fecal boli incidents, locomotor task	3.9	3.7	4.1	2.0	-1.8
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.4	-0.3	0.6
Bouts of movement, locomotor time 1	0.1	0.2	0.3	-0.5	-0.0
Total resting periods, locomotor time 1	0.2	0.2	0.4	-0.6	0.0
Rest time, locomotor task time 1	0.0	0.0	0.1	-0.3	0.1
Distance moved, locomotor task time 1	0.3	0.4	0.6	0.7	-0.5
Vertical activity count, locomotor time 1	0.4	0.4	0.5	0.7	-0.5
Time >=10cm from walls, locomotor time 2	1.3	1.4	1.6	-1.1	1.3
Bouts of movement, locomotor time 2	0.6	0.6	0.6	0.8	-0.8
Total resting periods, locomotor time 2	0.6	0.6	0.7	0.7	-0.9
Rest time, locomotor task time 2	0.1	0.1	0.2	-0.4	-0.0
Distance moved, locomotor task time 2	0.0	0.0	0.0	0.2	0.1
Vertical activity count, locomotor time 2	0.2	0.2	0.3	-0.3	0.5
Weight adjusted by age	0.3	0.3	0.4	0.4	-0.7
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.0	0.0	-0.2
Locomotion in novel chamber	0.5	0.6	0.6	0.8	-0.7
Locomotion in novel chamber post-restriction	3.2	3.8	4.2	1.9	-2.1
Progressive ratio	0.2	0.2	0.2	-0.4	0.4
Food seeking constrained by brief footshock	13.0	15.9	16.6	-3.9	4.1
Seeking ratio, punishment vs. effort	1.3	1.6	1.7	-1.2	1.3
Run reversals in cocaine runway, females	0.3	0.3	0.5	-0.3	0.7
Run reversals in cocaine runway, males	1.0	1.0	1.2	-0.9	1.1
Latency to leave start box in cocaine runway	0.5	0.5	0.6	-0.8	0.7
Latency to leave start box in cocaine runway, F	0.1	0.2	0.2	-0.5	0.3
Latency to leave start box in cocaine runway, M	1.8	1.8	1.8	-1.3	1.3
Cd content in liver	0.3	0.3	0.4	0.4	-0.6
Co content in liver	5.2	6.1	6.5	-2.6	2.4
Cu content in liver	0.1	0.1	0.1	-0.3	0.3
Fe content in liver	0.1	0.1	0.1	-0.3	0.3
K content in liver	1.7	1.7	2.0	1.2	-1.4
Mg content in liver	1.8	1.9	2.2	1.2	-1.5
Mn content in liver	0.2	0.2	0.4	0.1	-0.7
Na content in liver	1.4	1.5	1.7	-1.2	1.3
Rb content in liver	0.4	0.5	0.6	0.6	-0.8
Se content in liver	0.9	1.1	1.3	0.9	-1.1
Sr content in liver	0.1	0.1	0.1	0.3	-0.2
Zn content in liver	1.8	2.0	2.0	1.4	-1.4