Hub : Genes

Efcab7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000009782 0.4 0.13 2.5e-06 0.02 0.05 0.06 0.04 1.4e-03 1.2e-06 5.0e-07 4.3e-05
2 Eye gene expression ENSRNOG00000009782 0.38 0.19 7.4e-04 0.07 0.07 0.04 0.06 2.8e-02 3.7e-02 8.5e-02 4.8e-02
3 LHb intron excision ratio chr5:114527793:114538940 0.88 0.07 3.2e-04 -0.01 0.04 -0.01 0 4.6e-01 4.9e-02 4.8e-01 2.9e-01
4 PL gene expression ENSRNOG00000009782 0.05 0.04 3.8e-04 0.04 0.05 0.05 0.04 5.5e-04 1.4e-04 1.8e-04 2.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
BMI with tail0.41.12.01.4-1.4-0.6-0.6
BMI without tail0.30.60.91.0-0.30.8-1.0
Body weight0.20.92.01.4-0.6-1.10.3
Epididymis fat weight0.92.14.32.11.3-0.51.5
Glucose0.30.51.10.3-1.0-0.9-0.1
Heart weight1.92.75.60.11.1-2.42.0
Left kidney weight0.72.04.91.2-0.4-2.21.1
Right kidney weight0.92.68.50.60.4-2.91.2
Tail length0.31.03.00.31.7-0.10.9
Length with tail0.20.71.30.50.8-0.81.2
Length without tail0.40.81.90.8-0.8-1.40.6
Liver weight, left1.62.54.92.21.5-0.91.5
Liver weight, right4.16.99.43.11.8-2.33.1
Parametrial fat weight1.83.56.90.6-2.2-1.3-2.6
Retroperitoneal fat weight0.20.61.21.10.40.70.8
Intraocular pressure0.40.61.10.51.01.00.1
Extensor digitorum longus weight0.83.37.42.70.2-1.81.5
Soleus weight0.00.10.30.60.2-0.3-0.0
Tibialis anterior weight4.314.928.1-2.0-5.3-0.2-5.3
Tibia length1.64.54.92.12.0-2.12.2
Number of licking bursts0.50.61.30.9-0.61.10.0
Food consumed during 24 hour testing period0.30.31.10.11.00.40.0
Times rat made contact with spout0.40.41.20.1-1.1-0.5-0.5
Mean time between licks in bursts3.54.99.30.62.7-1.63.1
Mean num. licks in bursts0.70.82.0-1.0-0.2-1.4-0.5
Std. dev. time between licks in bursts0.70.93.10.1-0.1-1.80.5
Water consumed over 24 hours1.51.82.51.6-1.3-1.5-0.6
Indifference point 0 sec4.16.616.8-0.7-4.1-0.2-3.0
Indifference point AUC1.01.22.1-1.5-1.00.5-1.2
Indifference point function ln k0.81.12.11.50.9-0.90.8
Indifference point function log k0.81.12.11.50.9-0.90.8
Delay discounting total patch changes 0 sec3.86.216.0-0.6-4.0-0.3-2.9
Delay discounting total patch changes 12 sec1.31.75.00.0-2.20.7-1.2
Delay discounting total patch changes 18 sec2.12.87.3-0.0-2.7-0.4-1.9
Delay discounting total patch changes 24 sec1.51.94.9-0.5-2.2-1.0-1.2
Delay discounting total patch changes 6 sec3.04.610.4-1.7-3.20.4-2.2
Delay discounting time to switch 0 sec1.52.34.31.01.52.11.2
Delay discounting water rate 0 sec0.91.42.9-0.8-1.7-0.3-1.4
Delay discounting water rate 12 sec2.23.36.50.2-2.5-1.4-2.2
Delay discounting water rate 18 sec0.40.51.50.3-1.2-0.3-0.6
Delay discounting water rate 24 sec0.20.31.00.3-0.4-1.00.0
Delay discounting water rate 6 sec0.50.81.6-1.20.2-1.3-0.0
Locomotor activity0.10.20.4-0.1-0.7-0.6-0.1
Locomotor testing distance1.01.73.3-0.6-1.8-0.7-1.6
Locomotor testing rearing0.10.10.40.1-0.6-0.1-0.2
Light reinforcement 10.30.62.20.10.2-1.50.3
Light reinforcement 20.30.40.70.80.6-0.50.6
Reaction time number correct0.50.71.2-0.81.11.1-0.3
Reaction time mean minus median1.21.62.90.3-1.21.7-1.3
Reaction time mean minus median AUC0.50.61.60.4-0.61.2-0.7
Reaction time num false alarms0.50.72.5-1.6-0.40.1-0.6
Reaction time num false alarms AUC1.11.54.2-2.0-0.80.0-1.1
Reaction time trials correct on left0.50.71.2-0.81.11.1-0.3
Reaction time trials on left0.50.71.2-0.71.01.1-0.3
Reaction time mean1.41.92.91.7-1.11.7-1.0
Reaction time mean AUC1.72.35.32.3-1.01.6-0.6
Median of all reaction times1.21.62.61.6-0.91.6-0.7
Reaction time omissions0.71.01.50.8-1.21.0-1.0
Reaction time false alarm rate1.01.52.6-1.6-1.4-0.3-1.1
Reaction time premature initiation rate1.01.33.2-1.80.3-1.30.5
Reaction time premature initiations0.71.02.3-1.50.9-0.70.5
Std. dev. reaction times1.92.64.21.0-2.01.3-1.9
Reaction time trials completed0.50.71.2-0.71.01.1-0.3
Reaction time trials AUC0.50.71.2-0.81.01.1-0.3
Social response proportion0.70.72.5-0.2-0.31.6-0.6
Social responses0.10.10.30.0-0.30.60.4
Social time0.40.51.20.4-0.81.1-0.2
Conditioned locomotion2.12.69.03.0-0.51.00.1
Cocaine response after cond. corrected0.80.81.40.5-1.21.2-0.6
Cocaine response after cond. not corrected0.40.51.10.3-1.00.4-0.7
Cocaine response before conditioning0.60.71.8-1.00.4-1.3-0.3
Saline control response0.00.00.1-0.3-0.20.10.0
Condit. Reinf. active minus inactive responses0.60.71.5-0.50.9-1.20.6
Condit. Reinf. active-inactive response ratio0.10.10.1-0.30.3-0.30.1
Condit. Reinf. active responses1.11.54.0-1.20.6-2.00.3
Condit. Reinf. inactive responses0.91.12.1-0.41.1-1.50.9
Condit. Reinf. lever presses2.23.06.7-1.1-2.0-0.3-2.6
Condit. Reinf. lever reinforcers received1.21.73.5-1.70.3-1.9-0.0
Pavlov. Cond. lever latency1.01.43.00.41.2-1.11.7
Pavlov. Cond. magazine entry latency1.31.52.80.2-1.41.2-1.7
Pavlov. Cond. change in total contacts1.11.63.8-0.6-1.30.6-2.0
Pavlov. Cond. index score1.21.53.5-0.3-1.50.5-1.9
Pavlov. Cond. latency score0.91.22.70.0-1.30.4-1.7
Pavlov. Cond. lever contacts1.62.35.2-0.6-1.51.2-2.3
Pavlov. Cond. magazine entry number0.70.81.1-0.40.9-1.11.1
Pavlov. Cond. intertrial magazine entries1.01.32.5-0.51.50.21.6
Pavlov. Cond. lever-magazine prob. diff.1.11.43.2-0.4-1.40.5-1.8
Pavlov. Cond. response bias1.41.94.2-0.5-1.41.1-2.0
Conditioned reinforcement - actives0.20.20.30.50.60.6-0.0
Conditioned reinforcement - inactives0.70.81.61.3-0.2-1.20.6
Conditioned locomotion0.40.51.31.1-0.60.7-0.1
Intermittent access intake day 1-15 change1.71.73.4-0.41.81.60.8
Intermittent access intake escalation1.61.62.9-0.61.61.70.7
Intermittent access intake escalation 21.01.02.2-0.71.50.90.6
Intermitt. access day 1 inactive lever presses2.12.26.10.4-1.4-2.5-0.8
Intermitt. access day 15 inactive lever presses1.01.12.80.80.5-1.70.7
Intermitt. access escalation Index2.82.57.8-2.81.30.6-0.3
Intermittent access day 1 total infusions0.20.30.70.6-0.10.80.0
Intermittent access day 15 total infusions1.82.06.20.90.82.50.5
Intermittent access terminal intake (last 3 days)0.70.81.90.90.41.40.2
Intermittent access total infusions1.71.95.01.60.12.20.3
Intermittent access day 1 locomotion1.61.63.71.2-0.71.9-1.0
Intermittent access day 15 total locomotion1.01.02.40.90.01.6-1.0
Intermittent access total locomotion1.61.83.71.6-0.21.9-0.8
Intermittent access standard deviation2.22.35.41.70.62.30.7
Cocaine induced anxiety1.21.34.00.31.02.00.3
Post-drug Anxiety1.11.22.60.41.60.61.3
Baseline Anxiety1.21.34.00.30.4-2.01.0
Lifetime Intake1.31.44.71.00.02.20.0
Incentive Sensitization - Responses0.50.51.4-0.3-0.11.2-0.8
Incentive Sensitization - Breakpoint0.70.71.8-0.2-0.11.3-0.9
Progressive ratio test 1 active lever presses2.82.94.92.21.61.41.5
Progressive ratio test 1 breakpoint3.63.76.32.51.81.51.8
Progressive ratio test 1 inactive lever presses1.31.43.71.90.71.00.7
Progressive ratio test 2 active lever presses1.71.86.21.00.32.5-0.2
Progressive ratio test 2 breakpoint1.82.06.01.30.32.5-0.2
Progressive ratio test 2 inactive lever presses0.30.31.0-0.3-0.01.0-0.3
Total sessions with >9 infusions1.21.32.51.60.80.91.1
Short access day 1 total inactive lever presses0.50.51.30.5-1.2-0.2-0.7
Short access day 10 total inactive lever presses2.62.88.6-0.5-1.2-2.9-1.0
Short access day 1 total infusions0.10.10.30.10.30.60.1
Short access day 10 total infusions2.62.95.32.3-0.92.3-0.2
Short access total infusions1.01.13.80.6-0.22.0-0.1
Short access day 1 locomotion0.70.81.30.4-0.61.1-1.1
Short access day 10 total locomotion1.01.11.51.2-1.21.0-0.8
Short access total locomotion1.81.84.21.7-0.32.0-0.1
Compulsive drug intake2.92.95.1-1.8-1.70.1-2.3
One hour access (0.3 mA shock)2.02.37.70.6-0.32.8-1.0
One hour access (shock baseline)2.42.84.52.11.12.11.1
Number of responses in last shaping day2.52.66.92.6-1.90.0-0.1
Context. condit. distance diff. score2.53.14.81.70.9-2.21.9
Locomotion velocity, session 10.40.40.90.5-1.00.3-0.6
Locomotion distance, session 11.01.44.12.00.60.50.8
Locomotion velocity, session 20.20.20.6-0.50.80.3-0.2
Locomotion distance, session 20.40.61.21.1-0.10.5-0.9
Locomotion velocity, session 30.40.40.90.90.10.90.2
Locomotion distance, session 30.40.41.31.1-0.30.50.2
Stereotopy head waving bouts, day 30.60.71.7-0.61.30.00.9
Stereotopy head waving duration, day 30.70.92.3-0.51.50.21.0
Locomotion velocity, session 70.60.71.50.21.2-0.51.0
Locomotion distance, session 70.40.51.20.41.1-0.40.8
Stereotopy head waving bouts, day 70.50.61.5-0.2-1.20.1-0.9
Stereotopy head waving duration, day 70.91.12.2-0.5-1.50.7-1.2
Locomotion velocity, session 80.20.20.60.8-0.1-0.30.5
Locomotion distance, session 80.71.12.61.60.8-0.70.8
Degree of sensitization distance0.50.51.0-1.00.2-0.9-0.1
Degree of sensitization stereotypy0.91.02.2-0.5-1.50.6-1.2
Condit. Reinf. active minus inactive responses0.50.50.90.1-0.80.8-1.0
Condit. Reinf. active-inactive response ratio0.30.40.80.2-0.90.5-0.6
Condit. Reinf. active responses1.01.22.2-0.3-1.21.0-1.5
Condit. Reinf. inactive responses0.40.50.8-0.2-0.80.7-0.9
Incentive salience index mean0.70.91.80.3-1.00.7-1.3
Condit. Reinf. lever presses0.30.40.60.8-0.6-0.1-0.7
Time in familiar zone, hab. session 12.42.25.42.30.7-0.41.7
Time in novel zone, hab. session 13.83.76.8-2.3-1.60.5-2.6
Total zone transitions, hab. session 11.31.83.71.91.20.81.3
Total locomotion distance, hab. session 10.50.71.81.30.7-0.60.5
Locomotion velocity, hab. session 10.40.61.41.20.8-0.00.5
Time in familiar zone, hab. session 21.41.45.12.3-0.20.50.6
Time in novel zone, hab. session 21.21.23.9-2.0-0.2-0.1-0.9
Total zone transitions, hab. session 24.05.17.62.32.81.02.5
Total locomotion distance, hab. session 22.43.15.41.72.30.22.1
Locomotion velocity, hab. session 22.12.85.51.52.30.41.9
Novel to familiar place preference ratio0.90.91.4-1.1-0.9-0.3-1.2
Novelty place preference0.90.91.9-1.4-0.6-0.8-0.9
Time in novel zone, NPP test1.01.11.6-1.3-0.8-1.0-1.0
Total zone transitions, NPP test1.42.02.61.51.60.91.6
Total locomotion distance, NPP test0.60.82.10.51.50.11.0
Locomotion velocity, NPP test0.60.92.00.71.40.41.0
Pavlov. Cond. lever latency1.72.14.1-1.62.0-0.11.3
Pavlov. Cond. magazine entry latency0.30.41.21.1-0.10.80.2
Pavlov. Cond. change in total contacts1.11.11.51.2-1.20.3-1.2
Pavlov. Cond. index score0.91.22.41.5-1.30.2-0.7
Pavlov. Cond. latency score1.01.32.41.6-1.40.4-0.8
Pavlov. Cond. lever contacts1.11.32.71.6-1.40.1-0.8
Pavlov. Cond. magazine entry number0.40.61.5-1.20.1-0.8-0.2
Pavlov. Cond. intertrial magazine entries1.51.83.6-1.01.41.90.7
Pavlov. Cond. lever-magazine prob. diff.0.81.02.01.4-1.20.4-0.7
Pavlov. Cond. response bias0.60.82.31.5-0.80.1-0.3
Bone: apparent density1.22.05.5-2.41.1-1.00.5
Bone surface1.93.46.5-2.5-1.0-1.6-1.9
Bone volume1.42.47.7-2.8-0.0-1.2-0.7
Bone: connectivity density2.33.69.0-3.0-1.2-0.9-1.8
Bone: cortical apparent density3.85.09.71.23.10.22.9
Bone: cortical area0.20.20.8-0.10.10.4-0.9
Bone: cortical porosity0.40.40.9-0.5-0.90.1-0.7
Bone: cortical porosity0.60.61.70.0-1.30.1-0.9
Bone: cortical thickness0.30.51.51.20.60.10.4
Bone: cortical thickness0.70.82.61.60.2-0.80.1
Bone: cortical tissue density3.74.89.31.23.00.22.9
Bone: elastic displacement0.50.51.00.00.7-0.81.0
Bone: elastic work0.60.81.60.30.8-0.91.3
Bone: endosteal estimation0.71.62.6-1.6-0.5-1.5-1.1
Bone: endosteal perimeter1.12.35.5-2.4-0.60.0-1.8
Bone: final force0.30.51.30.61.1-0.30.4
Bone: final moment0.10.20.30.40.4-0.5-0.2
Bone: marrow area0.71.42.1-1.5-0.5-1.4-1.1
Bone: maximum diameter0.50.91.8-0.7-0.31.0-1.4
Bone: maximum force0.10.10.30.30.6-0.4-0.1
Bone: maximum moment0.20.30.60.1-0.3-0.8-0.7
Bone: minimum diameter1.01.83.6-1.9-1.0-0.2-1.7
Bone: periosteal estimation0.40.91.8-1.0-0.4-0.7-1.4
Bone: periosteal perimeter0.71.22.3-1.4-0.30.5-1.5
Bone: post-yield work1.01.43.60.5-1.2-0.1-1.9
Bone: stiffness0.20.30.60.50.6-0.80.0
Bone: tissue strength0.90.81.6-0.6-0.80.9-1.3
Bone: trabecular number0.91.43.9-2.00.6-1.20.3
Bone: trabecular spacing0.70.93.61.9-0.20.30.1
Bone: trabecular thickness0.40.40.8-0.90.90.00.4
Bone: trabecular tissue density7.810.922.51.24.7-0.14.4
Breakpoint value in progressive ratio session0.40.40.90.90.2-0.70.6
Distance traveled before self-admin0.40.41.00.6-0.4-1.0-0.1
Distance traveled after self-admin0.80.81.4-1.2-0.80.2-1.1
Delta time in closed arm before/after self-admin1.01.02.91.7-0.9-0.4-0.3
Delta time in open arm before/after self-admin1.21.22.3-0.7-0.11.5-1.4
Diff in mean of infusions in LGA sessions0.91.01.91.4-0.3-1.20.7
Extinction: sum of active levers before priming1.11.12.60.40.6-1.61.2
Active lever presses in extinction session 61.51.43.71.9-0.9-1.1-0.1
Delta distance traveled before/after self-admin2.02.13.9-2.0-1.01.2-1.4
Delta ambulatory time before/after self-admin1.92.04.5-2.1-0.31.5-1.1
Time in closed arm before self-admin1.11.23.5-0.90.81.9-0.2
Time in closed arm after self-admin0.40.41.10.8-0.21.1-0.0
Time in open arm before self-admin0.70.81.90.4-1.0-1.40.0
Time in open arm after self-admin1.11.22.5-0.8-1.20.0-1.6
Sum of active levers in priming session hrs 5-63.13.15.52.10.4-2.31.5
Time to tail flick, vehicle, before self-admin1.01.02.00.2-1.40.3-1.4
Time to tail flick, vehicle, after self-admin0.60.61.1-1.1-0.30.4-1.0
Time to tail flick, test, before self-admin0.40.41.5-1.2-0.30.20.0
Time to tail flick, test, after self-admin1.51.53.0-1.70.4-1.7-0.1
Delta time to tail flick, vehicle, before/after SA0.90.92.4-0.41.5-0.60.8
Delta time to tail flick, test, before/after SA0.50.50.7-0.80.2-0.8-0.7
Ambulatory time before self-admin1.01.13.70.6-0.4-1.90.5
Ambulatory time after self-admin0.80.91.4-1.2-0.80.3-1.2
Total heroin consumption0.81.01.51.01.20.21.2
Area under the delay curve0.91.01.41.00.51.21.0
Delay disc. indifference point, 0s delay2.42.65.91.51.3-0.82.4
Delay disc. indifference point, 16s delay1.51.52.40.8-1.41.5-1.0
Delay disc. indifference point, 2s delay0.60.71.80.60.6-0.61.3
Delay disc. indifference point, 24s delay0.80.82.60.7-0.31.60.1
Delay disc. indifference point, 4s delay2.42.54.70.92.00.72.2
Delay disc. indifference point, 8s delay1.31.42.01.31.01.01.4
Delay discount exponential model param0.80.91.6-0.9-0.4-1.3-1.0
Delay discount hyperbolic model param1.01.11.5-1.0-0.6-1.2-1.2
Fecal boli incidents, locomotor time 11.01.12.51.3-0.51.6-0.1
Change in fecal boli incidents, locomotor task0.50.40.70.30.8-0.80.6
Time >=10cm from walls, locomotor time 10.10.10.5-0.0-0.30.7-0.1
Bouts of movement, locomotor time 11.31.42.61.5-1.6-0.8-0.1
Total resting periods, locomotor time 11.01.12.20.8-1.5-1.2-0.1
Rest time, locomotor task time 10.60.72.10.80.1-1.50.0
Distance moved, locomotor task time 10.50.51.5-1.20.5-0.20.4
Vertical activity count, locomotor time 10.50.51.4-1.20.60.20.1
Time >=10cm from walls, locomotor time 21.71.82.71.21.1-1.41.6
Bouts of movement, locomotor time 20.40.50.90.4-0.90.1-1.0
Total resting periods, locomotor time 20.50.50.90.5-0.90.3-0.9
Rest time, locomotor task time 20.10.10.30.40.10.5-0.4
Distance moved, locomotor task time 21.82.15.4-0.90.8-2.31.3
Vertical activity count, locomotor time 20.91.02.8-0.60.3-1.70.8
Weight adjusted by age1.41.64.5-2.1-0.60.5-1.1
Seeking ratio, delayed vs. immediate footshock1.11.33.80.8-0.8-2.00.3
Locomotion in novel chamber0.60.81.50.3-1.2-0.3-1.1
Locomotion in novel chamber post-restriction1.51.74.01.7-0.02.0-0.1
Progressive ratio0.40.51.2-0.10.81.10.4
Food seeking constrained by brief footshock2.53.04.81.61.9-1.22.2
Seeking ratio, punishment vs. effort0.91.12.70.80.4-1.60.9
Run reversals in cocaine runway, females0.60.62.2-0.4-0.0-1.50.3
Run reversals in cocaine runway, males0.70.61.10.7-1.00.4-0.9
Latency to leave start box in cocaine runway0.60.61.01.00.8-0.80.5
Latency to leave start box in cocaine runway, F0.10.10.30.60.40.1-0.0
Latency to leave start box in cocaine runway, M1.01.02.60.50.6-1.60.9
Cd content in liver1.92.13.50.4-1.8-1.9-1.3
Co content in liver1.92.28.6-0.1-0.3-2.90.4
Cu content in liver0.10.10.20.50.10.10.4
Fe content in liver0.81.01.8-0.0-0.8-1.3-1.2
K content in liver0.70.71.60.11.2-0.21.0
Mg content in liver1.71.74.4-1.30.32.1-0.8
Mn content in liver0.80.93.41.8-0.30.20.0
Na content in liver2.32.54.20.12.1-1.91.5
Rb content in liver0.60.81.11.10.90.60.9
Se content in liver1.01.21.80.8-1.3-1.1-1.1
Sr content in liver0.30.30.5-0.6-0.1-0.7-0.5
Zn content in liver1.01.11.8-0.9-0.71.3-1.1