Hub : Genes

Esd

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000009512 0.17 0.07 1.1e-16 0.12 0.12 0.11 0.11 1.1e-12 1.1e-12 1.6e-12 1.2e-12
2 BLA gene expression ENSRNOG00000009512 0.57 0.1 0.0e+00 0.5 0.55 0.56 0.56 1.8e-30 6.5e-35 3.6e-35 8.0e-36
3 Brain gene expression ENSRNOG00000009512 0.57 0.09 0.0e+00 0.49 0.52 0.52 0.53 1.0e-51 1.5e-56 4.2e-56 3.3e-57
4 Brain mRNA stability ENSRNOG00000009512 0.06 0.03 1.0e-03 0.02 0.03 0.02 0.03 4.8e-03 1.1e-03 2.4e-03 2.2e-03
5 Eye gene expression ENSRNOG00000009512 0.53 0.15 7.6e-04 0.01 0.05 0 0.03 1.9e-01 5.6e-02 3.0e-01 1.1e-01
6 IL gene expression ENSRNOG00000009512 0.48 0.12 9.6e-08 0.3 0.23 0.27 0.29 6.5e-08 2.9e-06 4.1e-07 9.0e-08
7 LHb gene expression ENSRNOG00000009512 0.5 0.13 9.6e-09 0.45 0.41 0.41 0.41 6.0e-12 6.2e-11 8.7e-11 5.8e-11
8 Liver alternative TSS ENSRNOT00000013324 0.22 0.08 5.6e-17 0.12 0.11 0.1 0.11 3.6e-13 1.8e-12 7.1e-11 1.2e-12
9 Liver alternative TSS ENSRNOT00000106692 0.23 0.09 1.1e-16 0.12 0.11 0.1 0.12 5.9e-13 1.8e-12 5.2e-11 1.1e-12
10 Liver mRNA stability ENSRNOG00000009512 0.03 0.02 1.7e-03 0.01 0.01 0.01 0 5.0e-02 3.0e-02 8.8e-03 8.9e-02
11 NAcc gene expression ENSRNOG00000009512 0.31 0.11 1.8e-15 0.2 0.2 0.19 0.2 9.0e-15 7.8e-15 4.7e-14 4.7e-15
12 OFC gene expression ENSRNOG00000009512 0.58 0.14 2.4e-06 0.19 0.19 0.15 0.2 3.1e-05 3.2e-05 1.8e-04 1.6e-05
13 PL gene expression ENSRNOG00000009512 0.43 0.11 0.0e+00 0.39 0.4 0.39 0.39 1.4e-31 2.3e-32 2.3e-31 1.5e-31

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
BMI with tail0.82.64.20.2-1.9-1.81.2-1.6-2.0-1.8-1.81.80.8-1.7-1.8-1.7
BMI without tail0.20.31.31.1-0.1-0.2-0.8-0.0-0.5-0.4-0.50.5-0.50.1-0.9-0.3
Body weight0.31.26.32.50.70.7-1.21.20.30.70.8-0.8-1.40.80.60.9
Epididymis fat weight0.92.04.21.81.21.1-1.91.70.81.21.3-1.3-2.11.51.21.1
Glucose2.03.15.3-0.8-1.8-1.71.2-1.9-1.8-1.8-2.22.21.2-1.6-2.3-1.8
Heart weight1.72.44.00.71.21.6-1.51.81.31.71.8-1.8-1.11.22.01.7
Left kidney weight1.33.68.62.91.51.4-2.02.21.61.51.5-1.5-2.91.71.61.5
Right kidney weight2.26.416.34.02.11.8-2.92.91.81.81.9-1.9-4.02.41.72.0
Tail length2.16.39.62.22.72.4-3.12.82.42.32.3-2.3-2.72.82.02.3
Length with tail1.76.27.92.02.52.4-2.22.82.52.52.6-2.6-2.32.52.72.5
Length without tail0.30.62.3-0.20.50.70.30.70.70.91.1-1.10.20.31.50.9
Liver weight, left0.20.32.0-0.8-0.4-0.41.4-0.2-0.10.10.2-0.2-0.0-0.61.0-0.2
Liver weight, right1.01.72.5-0.2-1.5-1.41.2-1.3-1.6-1.5-1.41.40.4-1.3-1.4-1.4
Parametrial fat weight0.61.12.5-0.3-1.1-0.90.4-1.1-1.1-1.1-1.21.21.0-1.0-1.6-1.1
Retroperitoneal fat weight0.82.54.00.6-1.7-1.91.3-1.4-2.0-1.8-1.81.8-0.4-1.3-1.7-1.8
Intraocular pressure0.10.20.90.60.20.1-0.70.40.0-0.1-0.00.0-1.00.5-0.10.0
Extensor digitorum longus weight0.41.66.5-2.5-0.8-0.32.1-1.1-0.5-0.4-0.10.12.4-1.30.4-0.1
Soleus weight0.61.67.5-2.7-0.00.51.3-0.40.60.60.8-0.82.7-0.61.40.6
Tibialis anterior weight0.20.72.3-1.1-0.8-0.31.3-0.8-0.6-0.5-0.30.31.5-1.1-0.2-0.1
Tibia length3.49.529.35.42.72.2-3.73.52.02.02.2-2.2-4.33.11.92.4
Number of licking bursts1.01.23.21.4-0.9-1.0-0.2-0.6-1.2-1.2-1.31.3-0.7-0.4-1.8-1.0
Food consumed during 24 hour testing period0.70.92.20.11.00.8-0.51.01.01.01.1-1.1-0.80.91.50.8
Times rat made contact with spout0.60.71.81.3-0.4-0.7-0.5-0.2-0.9-0.9-0.70.7-1.3-0.1-1.0-0.9
Mean time between licks in bursts0.50.61.70.40.81.0-1.30.80.80.80.7-0.7-0.20.90.20.9
Mean num. licks in bursts0.20.20.9-0.50.40.4-0.10.40.50.50.7-0.7-0.20.30.90.3
Std. dev. time between licks in bursts2.02.43.70.61.71.8-1.41.61.91.91.6-1.6-0.01.61.51.9
Water consumed over 24 hours0.20.30.5-0.0-0.6-0.50.3-0.5-0.7-0.7-0.40.40.5-0.6-0.5-0.5
Indifference point 0 sec2.64.19.63.11.71.8-2.42.41.41.81.8-1.8-2.11.81.72.0
Indifference point AUC1.11.35.0-2.2-0.9-0.61.4-1.2-0.5-0.5-0.50.51.9-1.2-0.2-0.8
Indifference point function ln k0.71.07.62.80.20.1-1.10.8-0.2-0.00.0-0.0-1.70.7-0.30.3
Indifference point function log k0.71.07.62.80.20.1-1.10.8-0.2-0.00.0-0.0-1.70.7-0.30.3
Delay discounting total patch changes 0 sec2.23.69.93.11.51.6-2.22.31.21.61.6-1.6-2.11.71.51.8
Delay discounting total patch changes 12 sec1.41.92.51.01.31.5-1.41.51.31.41.6-1.6-0.31.21.51.5
Delay discounting total patch changes 18 sec0.30.40.80.9-0.9-0.60.4-0.4-0.9-0.7-0.50.50.1-0.9-0.5-0.5
Delay discounting total patch changes 24 sec0.30.41.51.20.60.6-0.80.80.20.40.5-0.5-0.60.60.30.7
Delay discounting total patch changes 6 sec0.30.43.31.8-0.10.0-0.70.5-0.4-0.00.1-0.1-0.9-0.00.00.1
Delay discounting time to switch 0 sec0.00.10.30.50.3-0.0-0.10.10.1-0.0-0.00.0-0.40.3-0.20.0
Delay discounting water rate 0 sec0.50.83.21.80.50.5-1.51.00.20.40.4-0.4-1.60.80.20.6
Delay discounting water rate 12 sec0.20.30.80.9-0.5-0.70.3-0.2-0.6-0.6-0.60.6-0.8-0.3-0.4-0.5
Delay discounting water rate 18 sec0.20.31.40.4-0.2-0.5-0.0-0.1-0.5-0.5-0.40.4-1.2-0.0-0.5-0.5
Delay discounting water rate 24 sec2.12.94.40.9-1.7-2.10.9-1.4-2.1-2.0-2.12.1-0.8-1.3-2.1-1.9
Delay discounting water rate 6 sec0.40.62.20.70.70.4-0.50.80.70.80.6-0.6-1.50.90.80.6
Locomotor activity6.09.513.31.03.13.5-2.43.33.43.43.6-3.6-0.92.93.63.7
Locomotor testing distance3.35.57.31.62.52.5-2.12.72.52.42.5-2.5-1.22.52.42.7
Locomotor testing rearing4.87.610.41.83.03.0-2.43.12.92.93.0-3.0-1.02.83.03.2
Light reinforcement 11.32.55.11.1-1.3-1.70.5-1.3-1.8-2.0-2.02.0-0.3-1.1-2.3-1.7
Light reinforcement 21.62.13.5-0.6-1.4-1.60.9-1.5-1.6-1.9-1.71.7-0.0-1.2-1.8-1.9
Reaction time number correct0.81.13.5-1.7-1.0-0.50.7-1.2-0.8-0.9-0.80.81.9-0.9-1.1-0.7
Reaction time mean minus median0.40.51.10.70.70.7-0.10.80.90.70.8-0.80.00.50.91.0
Reaction time mean minus median AUC0.00.00.20.30.00.10.00.10.1-0.0-0.00.00.4-0.1-0.10.3
Reaction time num false alarms0.10.10.5-0.20.20.5-0.70.30.20.20.3-0.30.40.4-0.10.5
Reaction time num false alarms AUC0.10.10.5-0.10.30.5-0.70.30.30.10.2-0.2-0.10.5-0.20.3
Reaction time trials correct on left0.81.13.5-1.7-1.0-0.50.7-1.2-0.8-0.9-0.80.81.9-0.9-1.1-0.7
Reaction time trials on left0.81.13.5-1.7-1.0-0.50.7-1.2-0.7-0.8-0.80.81.9-0.9-1.1-0.7
Reaction time mean0.70.92.10.31.00.9-0.20.91.21.11.2-1.2-0.20.71.41.1
Reaction time mean AUC0.70.92.20.20.90.9-0.10.91.11.11.2-1.2-0.00.61.51.1
Median of all reaction times0.40.61.50.10.80.6-0.10.70.90.91.0-1.0-0.20.51.20.8
Reaction time omissions0.30.50.80.10.80.7-0.80.70.80.80.7-0.70.30.70.40.9
Reaction time false alarm rate0.30.40.90.80.60.5-0.80.70.40.40.4-0.4-1.00.70.20.5
Reaction time premature initiation rate1.11.44.4-0.6-1.2-1.42.1-1.3-0.9-1.2-1.11.10.4-1.4-0.4-1.4
Reaction time premature initiations2.13.16.2-1.7-1.8-1.72.5-2.0-1.4-1.8-1.61.61.6-2.0-1.1-1.8
Std. dev. reaction times0.20.30.90.20.50.50.30.50.70.60.6-0.60.20.21.00.7
Reaction time trials completed0.81.13.5-1.7-1.0-0.50.7-1.2-0.7-0.8-0.80.81.9-0.9-1.1-0.7
Reaction time trials AUC0.60.93.1-1.7-0.8-0.40.6-1.1-0.6-0.7-0.70.71.8-0.8-0.9-0.6
Social response proportion0.70.83.9-2.0-0.8-0.30.9-0.8-0.2-0.30.0-0.01.7-1.00.1-0.4
Social responses1.11.46.9-1.6-1.2-0.61.2-1.2-0.6-0.8-0.60.62.6-1.4-0.6-0.6
Social time4.45.78.20.72.42.6-2.22.52.72.52.9-2.9-1.02.22.72.6
Conditioned locomotion1.01.21.8-1.0-1.2-0.90.9-1.2-1.2-1.2-0.90.91.4-1.2-1.0-1.0
Cocaine response after cond. corrected3.74.15.3-2.2-2.2-1.92.3-2.3-1.9-1.9-1.81.82.2-2.3-1.7-1.9
Cocaine response after cond. not corrected1.01.23.6-1.4-1.0-0.71.0-1.2-0.8-0.8-0.90.91.9-1.0-1.0-0.8
Cocaine response before conditioning3.54.36.62.02.32.2-2.62.32.02.01.9-1.9-1.22.41.52.2
Saline control response0.81.12.61.60.70.8-1.21.30.50.61.0-1.0-1.40.90.90.8
Condit. Reinf. active minus inactive responses0.60.81.5-0.2-0.9-1.11.2-0.9-0.9-0.9-1.01.0-0.0-0.9-0.6-1.0
Condit. Reinf. active-inactive response ratio1.51.62.6-1.1-1.3-1.41.6-1.4-1.2-1.2-1.21.20.7-1.4-0.9-1.4
Condit. Reinf. active responses0.00.10.50.50.1-0.1-0.10.1-0.00.0-0.10.1-0.70.1-0.1-0.1
Condit. Reinf. inactive responses1.01.22.71.61.11.0-1.61.20.90.90.8-0.8-1.11.10.51.0
Condit. Reinf. lever presses1.72.35.91.81.41.3-1.91.71.11.11.3-1.3-2.41.61.11.2
Condit. Reinf. lever reinforcers received0.10.10.70.7-0.0-0.2-0.10.0-0.2-0.1-0.30.3-0.90.0-0.3-0.2
Pavlov. Cond. lever latency0.50.73.0-1.3-0.6-0.50.9-1.0-0.4-0.4-0.60.61.7-0.8-0.5-0.6
Pavlov. Cond. magazine entry latency1.11.33.11.81.11.0-1.41.30.80.70.9-0.9-1.21.20.71.1
Pavlov. Cond. change in total contacts0.20.30.8-0.20.50.40.10.50.50.50.6-0.6-0.60.50.90.6
Pavlov. Cond. index score0.30.42.11.40.40.3-0.50.70.10.10.3-0.3-1.30.60.20.5
Pavlov. Cond. latency score0.40.51.91.40.40.4-0.50.80.20.20.4-0.4-1.20.60.40.6
Pavlov. Cond. lever contacts1.42.05.31.81.31.1-1.51.61.01.01.2-1.2-2.31.51.11.2
Pavlov. Cond. magazine entry number0.20.31.3-1.1-0.4-0.40.8-0.6-0.2-0.1-0.20.20.5-0.5-0.0-0.5
Pavlov. Cond. intertrial magazine entries0.70.94.41.20.90.8-2.10.90.50.60.4-0.4-1.01.3-0.30.5
Pavlov. Cond. lever-magazine prob. diff.0.20.31.41.20.20.2-0.40.50.0-0.00.2-0.2-1.00.40.10.4
Pavlov. Cond. response bias0.81.12.81.70.90.8-1.21.20.60.60.8-0.8-1.61.10.51.0
Conditioned reinforcement - actives0.30.31.8-1.30.50.3-0.10.20.60.50.5-0.5-0.30.60.8-0.0
Conditioned reinforcement - inactives2.42.84.91.81.81.4-2.01.81.31.41.4-1.4-2.22.11.31.2
Conditioned locomotion2.32.84.2-0.11.81.9-1.41.71.81.91.9-1.9-0.41.82.11.7
Intermittent access intake day 1-15 change0.70.73.81.50.30.2-0.70.80.20.50.5-0.5-1.90.40.60.1
Intermittent access intake escalation0.60.52.41.30.20.2-0.70.80.20.60.6-0.6-1.60.20.70.2
Intermittent access intake escalation 20.80.81.70.60.70.7-0.61.00.91.11.1-1.1-1.00.51.30.6
Intermitt. access day 1 inactive lever presses1.01.11.70.8-1.3-1.10.9-0.9-1.3-1.1-1.11.10.2-1.2-0.9-0.9
Intermitt. access day 15 inactive lever presses0.80.81.31.1-0.7-1.10.8-0.7-0.9-1.1-1.11.1-0.8-0.5-0.9-1.0
Intermitt. access escalation Index0.10.00.2-0.10.20.3-0.40.10.00.10.1-0.10.30.2-0.20.3
Intermittent access day 1 total infusions0.60.73.41.8-0.3-0.5-0.60.1-0.7-0.6-0.60.6-1.40.1-0.8-0.6
Intermittent access day 15 total infusions0.80.93.01.7-0.7-0.9-0.1-0.2-1.0-0.7-0.70.7-1.7-0.4-0.6-1.0
Intermittent access terminal intake (last 3 days)0.50.63.51.1-0.4-0.7-0.2-0.1-0.7-0.5-0.50.5-1.9-0.1-0.4-0.9
Intermittent access total infusions0.70.82.81.7-0.6-0.8-0.3-0.1-0.9-0.7-0.70.7-1.6-0.2-0.7-0.9
Intermittent access day 1 locomotion0.70.74.52.1-0.4-0.6-0.50.0-0.7-0.7-0.70.7-0.9-0.0-1.0-0.4
Intermittent access day 15 total locomotion0.40.51.30.5-0.7-0.90.6-0.4-0.8-0.6-0.50.5-1.2-0.5-0.1-1.0
Intermittent access total locomotion0.30.32.41.5-0.1-0.2-0.40.4-0.3-0.00.0-0.0-1.30.20.1-0.2
Intermittent access standard deviation0.30.31.40.7-0.4-0.80.6-0.2-0.4-0.3-0.30.3-1.2-0.50.2-0.7
Cocaine induced anxiety4.14.77.30.32.42.2-1.32.22.52.52.5-2.5-1.22.22.72.3
Post-drug Anxiety0.10.10.30.40.50.20.10.30.50.20.2-0.2-0.50.40.40.2
Baseline Anxiety3.23.45.80.6-1.9-2.01.1-1.7-2.0-2.3-2.32.30.4-1.7-2.4-2.0
Lifetime Intake0.40.52.61.6-0.2-0.5-0.40.2-0.5-0.3-0.30.3-1.60.1-0.3-0.6
Incentive Sensitization - Responses2.62.68.90.71.81.2-1.71.61.61.41.4-1.4-3.01.91.50.8
Incentive Sensitization - Breakpoint2.72.710.30.91.81.1-1.71.61.61.41.4-1.4-3.21.91.50.7
Progressive ratio test 1 active lever presses0.30.30.60.4-0.6-0.60.0-0.3-0.6-0.5-0.60.6-0.4-0.3-0.5-0.8
Progressive ratio test 1 breakpoint0.50.51.00.2-0.8-0.80.2-0.6-0.9-0.8-0.80.8-0.3-0.5-0.8-1.0
Progressive ratio test 1 inactive lever presses1.31.43.31.8-1.3-1.20.1-0.6-1.5-1.3-1.31.3-0.7-0.9-1.4-1.2
Progressive ratio test 2 active lever presses0.30.32.90.20.1-0.4-0.2-0.0-0.0-0.2-0.20.2-1.70.2-0.0-0.8
Progressive ratio test 2 breakpoint0.50.54.90.70.4-0.2-0.50.30.20.10.1-0.1-2.20.50.3-0.5
Progressive ratio test 2 inactive lever presses0.91.05.41.70.80.4-1.11.00.50.50.5-0.5-2.31.00.60.2
Total sessions with >9 infusions0.00.00.20.30.10.0-0.50.20.1-0.0-0.00.0-0.30.3-0.2-0.1
Short access day 1 total inactive lever presses2.93.211.42.81.51.1-2.01.91.01.31.3-1.3-3.41.61.31.0
Short access day 10 total inactive lever presses0.00.00.20.5-0.10.0-0.10.0-0.2-0.0-0.00.00.1-0.20.00.0
Short access day 1 total infusions0.10.10.90.20.0-0.1-0.40.2-0.10.10.1-0.1-0.90.10.1-0.3
Short access day 10 total infusions1.21.34.42.10.80.7-1.41.30.50.70.7-0.7-1.91.40.50.7
Short access total infusions0.50.63.41.70.1-0.2-0.70.5-0.2-0.1-0.10.1-1.80.5-0.1-0.3
Short access day 1 locomotion1.41.52.40.91.41.0-0.91.31.21.21.3-1.3-1.31.51.21.1
Short access day 10 total locomotion0.30.40.70.50.50.6-0.80.70.40.60.7-0.7-0.40.70.50.7
Short access total locomotion1.01.02.81.70.90.7-1.21.20.70.70.8-0.8-1.11.10.70.9
Compulsive drug intake0.20.20.50.70.20.5-0.50.50.20.40.4-0.40.20.10.20.7
One hour access (0.3 mA shock)0.20.21.50.90.10.0-0.40.40.10.20.2-0.2-1.20.30.3-0.0
One hour access (shock baseline)0.00.10.4-0.10.2-0.0-0.00.00.10.10.1-0.1-0.60.30.3-0.3
Number of responses in last shaping day1.41.41.9-0.01.41.4-1.31.21.31.41.3-1.3-0.41.31.21.3
Context. condit. distance diff. score4.25.29.9-0.0-2.5-2.41.0-2.2-2.6-2.6-2.72.70.9-2.1-3.1-2.6
Locomotion velocity, session 10.40.40.9-1.00.40.60.10.30.60.60.8-0.80.80.30.80.6
Locomotion distance, session 10.91.12.00.11.21.0-0.51.01.31.31.3-1.3-0.51.01.41.1
Locomotion velocity, session 20.00.00.1-0.20.10.00.3-0.00.20.20.1-0.10.30.1-0.00.2
Locomotion distance, session 22.53.54.90.52.12.0-1.41.92.22.22.1-2.1-0.72.02.02.2
Locomotion velocity, session 30.50.60.8-0.8-0.7-0.80.8-0.9-0.6-0.6-0.90.90.4-0.8-0.8-0.8
Locomotion distance, session 30.50.50.90.0-0.8-0.80.4-0.7-0.8-0.8-0.80.80.3-0.8-1.0-0.8
Stereotopy head waving bouts, day 30.10.10.7-0.8-0.20.00.7-0.10.10.10.3-0.30.3-0.20.60.0
Stereotopy head waving duration, day 30.10.10.4-0.50.20.10.50.10.20.20.3-0.3-0.50.20.60.1
Locomotion velocity, session 72.93.26.9-0.4-1.7-1.70.7-1.9-1.8-1.8-2.22.21.1-1.6-2.6-2.0
Locomotion distance, session 70.70.92.5-0.9-0.8-0.60.1-1.0-0.8-0.8-1.01.01.6-0.8-1.3-0.8
Stereotopy head waving bouts, day 70.40.51.60.60.60.4-0.10.70.70.70.6-0.6-1.30.60.80.5
Stereotopy head waving duration, day 70.30.32.50.60.40.00.20.50.40.40.3-0.3-1.60.40.70.2
Locomotion velocity, session 81.61.92.90.2-1.4-1.61.0-1.3-1.6-1.6-1.61.6-0.0-1.3-1.7-1.7
Locomotion distance, session 80.30.41.31.2-0.2-0.4-0.7-0.1-0.5-0.5-0.60.6-0.4-0.0-1.2-0.4
Degree of sensitization distance0.70.71.6-1.2-0.6-0.60.5-1.0-0.6-0.6-0.80.81.3-0.7-0.9-0.8
Degree of sensitization stereotypy0.50.52.91.20.60.2-0.30.70.50.50.4-0.4-1.70.60.50.3
Condit. Reinf. active minus inactive responses0.80.91.70.90.90.7-0.41.10.90.91.1-1.1-1.20.91.30.9
Condit. Reinf. active-inactive response ratio0.10.10.4-0.70.00.00.6-0.10.20.20.2-0.20.5-0.00.50.2
Condit. Reinf. active responses0.91.14.01.80.80.6-0.81.10.60.60.8-0.8-2.00.90.80.8
Condit. Reinf. inactive responses2.32.710.03.21.20.9-1.91.70.70.70.9-0.9-3.11.50.51.0
Incentive salience index mean1.82.24.32.11.41.2-1.21.71.21.21.5-1.5-1.81.41.61.4
Condit. Reinf. lever presses2.33.18.93.01.61.3-1.82.01.31.31.5-1.5-2.31.61.41.6
Time in familiar zone, hab. session 10.60.51.00.5-0.9-0.80.1-0.5-1.0-1.0-0.70.7-0.3-0.7-0.8-0.9
Time in novel zone, hab. session 11.31.34.7-2.2-0.7-0.81.9-1.2-0.3-0.3-0.70.71.8-0.9-0.3-0.6
Total zone transitions, hab. session 10.60.81.8-0.80.80.9-0.10.71.11.11.1-1.10.10.71.40.9
Total locomotion distance, hab. session 11.31.84.0-0.51.31.4-0.41.21.61.61.7-1.70.11.02.01.5
Locomotion velocity, hab. session 13.75.37.50.72.42.5-1.82.42.62.62.7-2.7-0.92.32.72.5
Time in familiar zone, hab. session 21.41.52.6-0.6-1.4-1.10.7-1.3-1.2-1.2-1.21.21.3-1.3-1.6-1.1
Time in novel zone, hab. session 20.40.40.7-0.10.70.6-0.20.60.70.70.6-0.6-0.40.70.80.6
Total zone transitions, hab. session 22.43.25.30.32.01.7-0.91.82.12.12.0-2.0-1.31.82.31.7
Total locomotion distance, hab. session 22.23.05.60.11.91.6-0.81.72.12.12.0-2.0-1.11.62.41.6
Locomotion velocity, hab. session 23.04.17.30.12.21.9-1.12.02.42.42.4-2.4-1.11.92.72.0
Novel to familiar place preference ratio0.20.21.11.00.20.1-0.50.30.00.0-0.30.3-0.70.4-0.40.1
Novelty place preference0.30.31.91.40.2-0.0-0.70.3-0.1-0.1-0.30.3-0.90.4-0.60.1
Time in novel zone, NPP test0.30.31.41.2-0.1-0.3-0.4-0.1-0.4-0.4-0.70.7-0.40.0-1.0-0.2
Total zone transitions, NPP test1.21.72.10.91.41.2-0.91.41.41.41.4-1.4-1.31.31.41.2
Total locomotion distance, NPP test2.73.84.61.12.11.9-1.82.12.12.12.1-2.1-1.62.02.11.8
Locomotion velocity, NPP test3.24.65.61.32.32.0-2.02.32.32.32.3-2.3-2.02.22.41.9
Pavlov. Cond. lever latency1.31.75.4-2.3-1.1-0.91.2-1.5-0.9-0.9-1.01.02.1-1.0-1.2-1.0
Pavlov. Cond. magazine entry latency0.20.30.70.8-0.6-0.70.8-0.4-0.5-0.5-0.50.50.2-0.8-0.2-0.5
Pavlov. Cond. change in total contacts1.11.12.01.31.00.8-0.61.21.01.01.1-1.1-1.30.81.41.0
Pavlov. Cond. index score0.50.64.72.20.40.2-0.50.80.30.30.3-0.3-1.30.30.50.4
Pavlov. Cond. latency score0.60.75.02.20.50.2-0.60.80.30.30.4-0.4-1.50.30.50.4
Pavlov. Cond. lever contacts1.21.54.82.21.00.7-0.91.30.90.90.9-0.9-2.00.91.20.8
Pavlov. Cond. magazine entry number0.10.10.5-0.7-0.0-0.1-0.1-0.2-0.1-0.1-0.20.20.00.2-0.4-0.2
Pavlov. Cond. intertrial magazine entries0.60.73.71.30.70.4-0.90.90.40.40.4-0.4-1.90.90.40.4
Pavlov. Cond. lever-magazine prob. diff.0.40.54.12.00.30.2-0.50.70.20.20.3-0.3-1.20.20.40.4
Pavlov. Cond. response bias0.10.21.11.1-0.0-0.10.20.30.00.00.2-0.2-0.5-0.20.60.1
Bone: apparent density1.01.73.90.51.41.7-2.01.31.41.31.2-1.20.01.50.61.6
Bone surface0.71.22.50.51.11.4-1.61.11.01.01.0-1.00.41.10.61.4
Bone volume1.01.74.50.81.41.7-2.11.31.21.21.1-1.10.41.40.41.7
Bone: connectivity density0.40.61.20.80.80.8-1.10.90.60.60.6-0.6-0.70.90.50.7
Bone: cortical apparent density2.63.44.4-1.0-1.9-2.11.9-2.0-1.9-2.0-1.91.90.6-2.0-1.8-2.1
Bone: cortical area0.20.30.7-0.2-0.5-0.40.2-0.6-0.6-0.6-0.60.60.8-0.5-0.8-0.4
Bone: cortical porosity0.70.85.92.40.40.3-1.00.80.10.10.2-0.2-1.10.6-0.20.6
Bone: cortical porosity0.50.54.22.00.10.1-0.70.4-0.1-0.1-0.20.2-0.90.3-0.60.3
Bone: cortical thickness0.50.81.70.7-0.9-0.90.4-0.8-1.1-1.1-1.11.1-0.1-0.8-1.3-0.9
Bone: cortical thickness2.63.05.4-0.6-1.8-1.71.4-1.9-1.8-1.8-2.02.01.4-1.7-2.3-1.6
Bone: cortical tissue density2.33.04.0-1.0-1.8-2.01.8-1.9-1.8-1.9-1.81.80.5-1.8-1.7-2.0
Bone: elastic displacement0.30.40.80.90.70.4-0.30.70.60.60.5-0.5-0.80.70.50.7
Bone: elastic work0.70.91.61.31.00.9-1.01.00.90.80.8-0.8-0.71.00.51.1
Bone: endosteal estimation0.40.92.0-0.80.71.2-0.70.60.90.91.0-1.01.40.60.81.1
Bone: endosteal perimeter0.81.62.1-1.01.21.4-0.70.91.41.41.5-1.51.11.01.41.4
Bone: final force1.42.24.10.3-1.6-1.50.9-1.5-1.7-1.8-1.71.70.9-1.6-2.0-1.4
Bone: final moment0.91.42.90.4-1.2-1.20.7-1.1-1.4-1.4-1.41.40.5-1.2-1.7-1.0
Bone: marrow area0.41.01.8-0.70.81.2-0.80.70.91.01.1-1.11.40.70.81.1
Bone: maximum diameter0.71.32.8-1.4-1.1-0.91.2-1.3-0.9-0.9-0.90.91.7-1.1-0.9-0.9
Bone: maximum force0.30.51.20.1-0.8-0.50.2-0.7-0.8-0.9-0.80.80.7-0.7-1.1-0.5
Bone: maximum moment0.10.20.60.3-0.3-0.2-0.0-0.3-0.5-0.5-0.50.50.4-0.3-0.8-0.1
Bone: minimum diameter0.00.10.4-0.30.20.20.10.00.30.30.2-0.20.60.10.30.3
Bone: periosteal estimation0.10.22.0-0.80.10.4-0.2-0.10.20.20.3-0.31.40.1-0.10.4
Bone: periosteal perimeter0.10.22.0-1.00.00.20.2-0.30.20.20.1-0.11.4-0.1-0.00.2
Bone: post-yield work0.91.21.6-1.0-1.2-1.00.8-1.2-1.2-1.2-1.01.00.9-1.2-1.0-1.3
Bone: stiffness0.20.41.00.2-0.6-0.4-0.0-0.6-0.7-0.7-0.60.60.7-0.6-1.0-0.4
Bone: tissue strength0.40.40.6-0.30.80.5-0.40.50.70.70.5-0.5-0.80.80.70.4
Bone: trabecular number0.20.31.10.40.50.7-1.00.50.40.40.3-0.3-0.00.6-0.10.6
Bone: trabecular spacing0.50.71.8-0.9-0.9-0.81.3-0.9-0.7-0.7-0.60.60.9-1.0-0.3-0.7
Bone: trabecular thickness0.60.82.91.60.60.8-1.70.90.40.40.5-0.5-0.80.9-0.20.7
Bone: trabecular tissue density1.21.72.3-1.0-1.4-1.21.2-1.5-1.2-1.3-1.31.31.5-1.4-1.5-1.1
Breakpoint value in progressive ratio session1.61.72.50.3-1.5-1.21.2-1.3-1.6-1.3-1.41.41.6-1.4-1.5-1.0
Distance traveled before self-admin5.45.88.5-0.32.62.9-1.72.42.72.82.7-2.7-0.52.32.92.8
Distance traveled after self-admin0.80.85.3-2.30.50.60.50.10.70.90.9-0.90.30.21.40.3
Delta time in closed arm before/after self-admin0.30.20.8-0.5-0.4-0.40.9-0.6-0.1-0.3-0.30.30.9-0.5-0.1-0.4
Delta time in open arm before/after self-admin0.60.60.9-0.2-1.0-0.80.4-0.7-0.9-0.8-0.60.60.9-0.9-0.8-0.6
Diff in mean of infusions in LGA sessions2.73.04.80.1-1.9-2.02.2-1.8-2.0-1.7-1.91.90.8-1.9-1.5-1.8
Extinction: sum of active levers before priming0.20.21.71.30.0-0.1-0.50.1-0.3-0.2-0.30.3-0.40.2-0.5-0.1
Active lever presses in extinction session 60.20.21.20.40.30.0-0.50.3-0.00.10.2-0.2-1.10.50.2-0.2
Delta distance traveled before/after self-admin4.64.96.4-2.2-2.3-2.42.4-2.5-2.2-2.1-2.02.01.5-2.4-1.7-2.5
Delta ambulatory time before/after self-admin2.42.63.5-1.6-1.8-1.81.7-1.8-1.7-1.5-1.41.40.9-1.8-1.2-1.9
Time in closed arm before self-admin0.10.10.4-0.5-0.2-0.1-0.2-0.2-0.2-0.4-0.40.40.5-0.1-0.6-0.2
Time in closed arm after self-admin0.20.21.2-0.4-0.2-0.10.4-0.4-0.1-0.3-0.40.41.1-0.4-0.4-0.1
Time in open arm before self-admin1.51.62.4-0.61.31.5-1.11.11.41.51.4-1.4-0.81.21.41.1
Time in open arm after self-admin0.00.00.1-0.20.10.1-0.40.10.00.10.1-0.1-0.30.1-0.00.0
Sum of active levers in priming session hrs 5-61.11.13.2-1.8-1.2-0.80.9-1.2-1.1-0.7-0.70.71.2-1.1-0.7-1.0
Time to tail flick, vehicle, before self-admin0.70.73.81.9-0.2-0.7-0.30.1-0.6-0.7-0.60.6-1.60.1-0.7-0.6
Time to tail flick, vehicle, after self-admin0.60.61.0-0.3-0.9-0.70.6-0.8-0.9-0.9-0.80.80.9-0.7-1.0-0.6
Time to tail flick, test, before self-admin1.21.23.31.01.01.1-1.81.30.70.90.9-0.9-0.91.30.51.1
Time to tail flick, test, after self-admin0.20.20.40.4-0.2-0.3-0.6-0.1-0.4-0.4-0.30.3-0.6-0.0-0.6-0.6
Delta time to tail flick, vehicle, before/after SA0.40.41.2-1.1-0.6-0.40.7-0.7-0.5-0.5-0.50.51.0-0.6-0.4-0.4
Delta time to tail flick, test, before/after SA0.90.81.4-1.0-0.8-0.90.7-1.1-0.6-0.9-1.01.00.5-0.7-0.9-1.2
Ambulatory time before self-admin4.04.25.90.32.12.4-1.62.12.32.42.3-2.3-0.81.92.42.4
Ambulatory time after self-admin1.01.13.2-1.50.70.90.20.51.01.21.3-1.30.20.41.80.8
Total heroin consumption0.00.00.20.4-0.2-0.00.10.1-0.30.10.0-0.0-0.1-0.3-0.00.1
Area under the delay curve0.20.20.50.70.30.5-0.60.50.40.40.4-0.40.20.40.30.6
Delay disc. indifference point, 0s delay1.11.22.7-0.11.01.2-0.51.11.31.31.3-1.3-0.00.81.61.2
Delay disc. indifference point, 16s delay1.01.01.50.91.01.2-1.11.11.01.01.0-1.00.01.00.71.2
Delay disc. indifference point, 2s delay0.60.71.1-1.00.70.8-0.00.50.90.90.9-0.90.80.71.00.9
Delay disc. indifference point, 24s delay1.11.01.7-0.10.91.3-1.11.01.21.21.2-1.20.50.71.01.2
Delay disc. indifference point, 4s delay0.20.21.0-0.9-0.3-0.10.6-0.4-0.0-0.0-0.00.01.0-0.40.2-0.1
Delay disc. indifference point, 8s delay0.20.21.81.3-0.1-0.1-0.20.1-0.2-0.2-0.20.2-0.1-0.0-0.3-0.0
Delay discount exponential model param0.20.20.4-0.6-0.3-0.50.6-0.5-0.4-0.4-0.40.4-0.2-0.4-0.3-0.5
Delay discount hyperbolic model param0.10.10.2-0.3-0.2-0.40.3-0.3-0.3-0.3-0.30.3-0.4-0.2-0.3-0.4
Fecal boli incidents, locomotor time 15.96.48.71.42.82.6-2.92.82.52.62.5-2.5-2.62.92.22.4
Change in fecal boli incidents, locomotor task4.54.36.4-1.5-2.3-2.22.5-2.3-2.1-2.0-2.02.01.9-2.3-1.7-2.0
Time >=10cm from walls, locomotor time 11.01.01.31.01.10.8-1.01.10.70.81.0-1.0-1.11.11.00.9
Bouts of movement, locomotor time 10.30.30.9-1.0-0.0-0.51.0-0.7-0.4-0.4-0.50.50.5-0.1-0.0-0.6
Total resting periods, locomotor time 10.40.41.6-1.3-0.1-0.51.0-0.8-0.5-0.4-0.50.50.7-0.2-0.1-0.7
Rest time, locomotor task time 11.01.11.7-1.21.21.3-0.70.71.11.11.1-1.10.51.11.21.0
Distance moved, locomotor task time 10.40.41.20.3-1.1-0.90.6-0.5-0.6-0.6-0.50.50.3-1.1-0.5-0.6
Vertical activity count, locomotor time 10.00.00.3-0.1-0.2-0.30.5-0.00.1-0.00.1-0.1-0.2-0.20.1-0.0
Time >=10cm from walls, locomotor time 21.31.43.1-1.01.21.2-0.30.91.31.41.4-1.4-0.11.01.81.1
Bouts of movement, locomotor time 21.92.03.3-0.8-1.7-1.21.6-1.5-1.4-1.3-1.31.31.8-1.8-1.2-1.1
Total resting periods, locomotor time 21.21.32.0-0.4-1.4-1.01.2-1.2-1.2-1.1-1.11.11.3-1.4-1.0-0.9
Rest time, locomotor task time 20.10.20.40.0-0.3-0.40.2-0.4-0.5-0.5-0.40.4-0.6-0.3-0.3-0.5
Distance moved, locomotor task time 20.30.30.60.50.40.5-0.50.70.80.70.6-0.6-0.30.30.60.6
Vertical activity count, locomotor time 20.91.01.6-0.60.91.1-0.40.81.31.21.2-1.20.40.71.21.1
Weight adjusted by age2.52.85.6-1.01.71.7-0.51.42.02.12.0-2.0-0.01.62.41.6
Seeking ratio, delayed vs. immediate footshock0.30.31.4-0.3-0.5-0.41.2-0.4-0.1-0.2-0.20.21.0-0.80.3-0.1
Locomotion in novel chamber0.50.61.71.20.90.5-1.20.70.4-0.10.0-0.0-1.31.2-0.40.5
Locomotion in novel chamber post-restriction0.40.50.6-0.8-0.7-0.70.6-0.8-0.7-0.7-0.70.70.5-0.5-0.7-0.7
Progressive ratio2.42.73.90.0-1.7-1.91.3-1.6-2.0-1.8-1.91.9-0.5-1.5-2.0-1.9
Food seeking constrained by brief footshock4.35.39.3-2.5-2.4-2.13.0-2.7-1.9-1.9-1.91.92.6-2.8-1.7-2.1
Seeking ratio, punishment vs. effort1.11.32.5-1.50.71.10.10.51.31.21.3-1.31.60.21.51.1
Run reversals in cocaine runway, females0.00.00.10.10.10.1-0.10.20.30.20.0-0.0-0.10.00.20.0
Run reversals in cocaine runway, males0.90.91.71.30.80.8-0.71.10.80.90.9-0.9-1.10.71.01.0
Latency to leave start box in cocaine runway0.50.62.2-1.2-0.8-0.61.5-0.7-0.4-0.3-0.20.20.8-1.00.2-0.5
Latency to leave start box in cocaine runway, F0.40.51.8-0.8-0.9-0.61.4-0.6-0.4-0.2-0.20.20.7-1.10.3-0.5
Latency to leave start box in cocaine runway, M0.40.41.00.1-0.5-0.70.4-0.6-0.7-0.8-0.80.8-0.1-0.3-1.0-0.6
Cd content in liver0.60.71.10.31.00.7-0.80.91.01.00.7-0.7-0.81.00.90.7
Co content in liver0.91.14.0-2.0-0.9-0.61.0-1.1-0.6-0.6-0.70.71.8-0.9-0.6-0.8
Cu content in liver0.30.31.3-1.1-0.4-0.41.1-0.5-0.2-0.2-0.10.10.6-0.50.3-0.3
Fe content in liver0.10.10.4-0.4-0.1-0.30.6-0.30.10.1-0.30.30.5-0.2-0.0-0.2
K content in liver0.20.21.00.40.40.4-1.00.40.30.30.2-0.20.00.4-0.20.4
Mg content in liver0.91.01.7-0.31.01.1-1.31.01.11.11.1-1.1-0.11.00.90.9
Mn content in liver0.50.52.00.10.41.0-1.40.70.50.50.7-0.70.70.60.10.9
Na content in liver2.42.63.91.71.71.7-1.41.81.61.61.6-1.6-0.91.61.52.0
Rb content in liver0.40.51.60.20.80.4-0.40.70.80.80.5-0.5-1.30.70.90.3
Se content in liver0.40.51.5-0.30.20.70.20.50.60.60.9-0.91.10.11.20.9
Sr content in liver0.20.21.1-0.60.20.5-0.10.10.40.40.4-0.41.00.10.30.5
Zn content in liver3.84.16.40.22.32.2-1.11.92.52.52.3-2.3-0.32.02.52.3