Hub : Genes

Tbkbp1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression ENSRNOG00000009370 0.23 0.12 2.2e-08 0.09 0.09 0.07 0.08 2.6e-08 1.4e-08 2.3e-07 4.2e-08
2 Brain mRNA stability ENSRNOG00000009370 0.14 0.1 1.1e-04 0.05 0.04 0.04 0.04 2.0e-05 8.9e-05 7.7e-05 6.9e-05
3 Liver gene expression ENSRNOG00000009370 0.14 0.28 1.1e-03 0 0.02 0.02 0.01 2.6e-01 4.9e-03 5.1e-03 1.3e-02
4 NAcc gene expression ENSRNOG00000009370 0.58 0.3 0.0e+00 0.31 0.31 0.31 0.31 8.0e-24 9.5e-24 9.7e-24 1.8e-23

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
BMI with tail4.514.618.4-3.6-4.32.9-4.3
BMI without tail0.20.31.1-0.1-0.31.1-0.3
Body weight1.25.27.52.72.2-2.02.1
Epididymis fat weight0.20.50.90.90.8-0.20.7
Glucose0.50.72.10.50.51.50.4
Heart weight0.00.10.20.2-0.0-0.4-0.1
Left kidney weight2.98.312.03.53.1-1.63.0
Right kidney weight0.82.23.82.01.60.01.5
Tail length14.042.350.67.07.1-4.57.0
Length with tail14.051.358.97.77.6-5.77.5
Length without tail2.45.25.92.42.2-2.42.1
Liver weight, left0.61.01.11.01.0-1.11.0
Liver weight, right2.94.86.42.52.5-0.62.5
Parametrial fat weight0.20.51.6-0.3-0.31.3-0.4
Retroperitoneal fat weight0.31.01.61.20.91.00.9
Intraocular pressure2.12.93.21.81.8-1.51.7
Extensor digitorum longus weight1.24.811.71.91.5-3.41.3
Soleus weight0.51.64.7-0.7-0.82.2-0.8
Tibialis anterior weight0.72.44.31.41.3-2.11.2
Tibia length0.20.61.31.10.8-0.10.7
Number of licking bursts0.10.10.2-0.4-0.30.2-0.4
Food consumed during 24 hour testing period1.21.43.20.90.9-1.80.9
Times rat made contact with spout0.10.20.2-0.5-0.40.4-0.4
Mean time between licks in bursts0.10.10.5-0.0-0.0-0.7-0.1
Mean num. licks in bursts0.00.00.10.20.2-0.10.3
Std. dev. time between licks in bursts0.60.71.0-0.9-1.00.4-1.0
Water consumed over 24 hours0.10.10.2-0.3-0.0-0.4-0.2
Indifference point 0 sec0.81.34.3-0.6-0.72.1-0.6
Indifference point AUC0.20.20.8-0.1-0.2-0.9-0.3
Indifference point function ln k0.20.30.30.50.40.50.6
Indifference point function log k0.20.30.30.50.40.50.6
Delay discounting total patch changes 0 sec0.61.03.5-0.3-0.41.9-0.3
Delay discounting total patch changes 12 sec1.31.73.9-1.0-1.02.0-1.0
Delay discounting total patch changes 18 sec1.72.22.7-1.6-1.61.1-1.7
Delay discounting total patch changes 24 sec1.21.53.0-1.0-1.01.7-1.0
Delay discounting total patch changes 6 sec1.21.82.6-1.3-1.21.6-1.3
Delay discounting time to switch 0 sec0.20.40.5-0.7-0.60.5-0.6
Delay discounting water rate 0 sec0.20.30.40.60.40.70.3
Delay discounting water rate 12 sec0.91.41.91.41.3-0.61.3
Delay discounting water rate 18 sec1.01.31.81.31.30.21.3
Delay discounting water rate 24 sec0.30.41.6-0.1-0.31.3-0.2
Delay discounting water rate 6 sec0.00.10.2-0.1-0.10.4-0.2
Locomotor activity1.42.32.7-1.6-1.61.2-1.6
Locomotor testing distance4.16.87.6-2.8-2.62.4-2.6
Locomotor testing rearing2.13.33.7-1.9-1.81.8-1.7
Light reinforcement 12.13.94.3-2.1-2.01.8-2.0
Light reinforcement 20.30.40.6-0.6-0.50.8-0.6
Reaction time number correct0.30.41.20.30.4-1.10.4
Reaction time mean minus median0.20.30.4-0.6-0.5-0.5-0.6
Reaction time mean minus median AUC0.50.71.2-1.1-0.8-0.1-1.0
Reaction time num false alarms0.00.00.1-0.1-0.20.3-0.1
Reaction time num false alarms AUC0.00.00.00.00.00.20.1
Reaction time trials correct on left0.30.41.20.30.4-1.10.4
Reaction time trials on left0.30.41.20.30.4-1.10.3
Reaction time mean1.01.32.0-1.3-1.30.1-1.4
Reaction time mean AUC0.91.11.7-1.2-1.20.1-1.3
Median of all reaction times1.52.12.9-1.6-1.60.6-1.7
Reaction time omissions0.20.30.7-0.4-0.30.8-0.4
Reaction time false alarm rate0.10.20.7-0.2-0.20.9-0.1
Reaction time premature initiation rate0.20.30.40.50.60.20.6
Reaction time premature initiations0.40.60.80.80.8-0.70.9
Std. dev. reaction times0.10.20.3-0.5-0.4-0.1-0.6
Reaction time trials completed0.30.41.20.30.4-1.10.3
Reaction time trials AUC0.20.31.10.20.3-1.00.3
Social response proportion1.61.72.41.51.5-0.11.5
Social responses0.10.10.10.40.30.30.3
Social time0.60.81.3-0.9-1.1-0.1-1.0
Conditioned locomotion0.30.41.4-0.3-0.31.2-0.3
Cocaine response after cond. corrected2.93.28.9-1.1-1.23.0-1.1
Cocaine response after cond. not corrected2.12.38.4-0.5-0.52.9-0.5
Cocaine response before conditioning0.81.01.51.11.2-0.31.2
Saline control response0.00.00.1-0.3-0.10.10.0
Condit. Reinf. active minus inactive responses0.40.50.8-0.7-0.60.9-0.7
Condit. Reinf. active-inactive response ratio1.31.31.7-1.3-1.20.7-1.3
Condit. Reinf. active responses0.30.50.9-0.6-0.41.0-0.6
Condit. Reinf. inactive responses0.20.20.9-0.3-0.10.9-0.1
Condit. Reinf. lever presses0.20.20.50.30.7-0.40.4
Condit. Reinf. lever reinforcers received0.20.30.6-0.5-0.30.8-0.4
Pavlov. Cond. lever latency0.60.80.90.90.7-0.90.9
Pavlov. Cond. magazine entry latency0.91.01.61.01.3-0.51.1
Pavlov. Cond. change in total contacts0.40.50.9-0.7-0.41.0-0.6
Pavlov. Cond. index score0.10.20.6-0.10.10.8-0.1
Pavlov. Cond. latency score0.10.20.30.20.40.60.2
Pavlov. Cond. lever contacts0.70.91.6-0.9-0.61.3-0.9
Pavlov. Cond. magazine entry number0.30.30.5-0.5-0.7-0.5-0.6
Pavlov. Cond. intertrial magazine entries1.21.54.60.70.7-2.20.7
Pavlov. Cond. lever-magazine prob. diff.0.10.10.5-0.10.20.7-0.0
Pavlov. Cond. response bias0.50.71.8-0.7-0.41.4-0.7
Conditioned reinforcement - actives2.62.63.6-1.5-1.51.9-1.5
Conditioned reinforcement - inactives0.30.40.7-0.8-0.60.3-0.6
Conditioned locomotion4.04.87.6-1.9-2.02.8-2.0
Intermittent access intake day 1-15 change1.00.91.8-0.8-0.81.3-0.8
Intermittent access intake escalation1.11.11.7-0.9-0.91.3-0.9
Intermittent access intake escalation 20.50.50.5-0.6-0.70.6-0.7
Intermitt. access day 1 inactive lever presses0.10.20.3-0.6-0.30.3-0.4
Intermitt. access day 15 inactive lever presses3.23.65.0-2.2-2.01.1-2.0
Intermitt. access escalation Index0.20.20.5-0.1-0.50.7-0.4
Intermittent access day 1 total infusions0.00.00.00.10.10.10.1
Intermittent access day 15 total infusions0.30.40.8-0.5-0.50.9-0.5
Intermittent access terminal intake (last 3 days)0.50.60.6-0.8-0.80.7-0.8
Intermittent access total infusions0.00.10.2-0.1-0.10.4-0.1
Intermittent access day 1 locomotion0.00.00.1-0.10.10.30.1
Intermittent access day 15 total locomotion0.50.51.0-0.7-0.61.0-0.6
Intermittent access total locomotion0.80.92.0-0.8-0.71.4-0.7
Intermittent access standard deviation0.70.81.5-0.8-0.71.2-0.8
Cocaine induced anxiety0.30.31.10.30.1-1.10.0
Post-drug Anxiety0.40.40.8-0.5-0.5-0.9-0.5
Baseline Anxiety2.02.13.0-1.7-1.61.0-1.4
Lifetime Intake0.00.00.0-0.1-0.00.2-0.1
Incentive Sensitization - Responses0.40.40.6-0.7-0.60.7-0.7
Incentive Sensitization - Breakpoint0.50.50.8-0.6-0.60.9-0.7
Progressive ratio test 1 active lever presses0.30.30.70.40.50.90.5
Progressive ratio test 1 breakpoint0.40.40.50.50.70.70.7
Progressive ratio test 1 inactive lever presses0.40.51.2-0.6-0.41.1-0.4
Progressive ratio test 2 active lever presses0.20.30.5-0.5-0.30.7-0.4
Progressive ratio test 2 breakpoint0.20.30.6-0.4-0.30.8-0.4
Progressive ratio test 2 inactive lever presses0.10.20.3-0.5-0.4-0.3-0.4
Total sessions with >9 infusions0.50.61.9-0.4-0.31.4-0.3
Short access day 1 total inactive lever presses0.10.10.3-0.10.2-0.50.2
Short access day 10 total inactive lever presses0.40.51.8-0.3-0.1-1.3-0.2
Short access day 1 total infusions0.10.10.2-0.4-0.40.2-0.4
Short access day 10 total infusions0.10.20.5-0.2-0.30.7-0.2
Short access total infusions0.00.00.00.10.10.20.1
Short access day 1 locomotion1.11.12.8-0.8-0.71.7-0.7
Short access day 10 total locomotion0.60.72.3-0.5-0.31.5-0.2
Short access total locomotion0.50.51.7-0.4-0.31.3-0.3
Compulsive drug intake3.23.23.51.61.8-1.91.8
One hour access (0.3 mA shock)0.00.00.10.10.1-0.30.2
One hour access (shock baseline)1.92.22.5-1.4-1.51.6-1.5
Number of responses in last shaping day0.20.20.3-0.6-0.5-0.2-0.5
Context. condit. distance diff. score0.00.00.00.1-0.2-0.1-0.1
Locomotion velocity, session 10.20.20.3-0.4-0.5-0.2-0.5
Locomotion distance, session 13.85.07.22.02.1-2.72.1
Locomotion velocity, session 22.42.83.51.91.8-1.21.8
Locomotion distance, session 23.44.95.12.22.3-2.22.2
Locomotion velocity, session 30.20.30.40.60.6-0.30.6
Locomotion distance, session 33.94.24.72.12.1-1.82.2
Stereotopy head waving bouts, day 34.55.49.7-1.9-2.03.1-2.0
Stereotopy head waving duration, day 32.02.44.3-1.3-1.42.1-1.3
Locomotion velocity, session 71.71.92.11.41.4-1.31.4
Locomotion distance, session 74.25.46.62.42.6-1.72.5
Stereotopy head waving bouts, day 71.21.41.6-1.2-1.31.0-1.2
Stereotopy head waving duration, day 70.70.91.2-1.1-1.10.4-1.0
Locomotion velocity, session 80.81.03.20.70.4-1.80.5
Locomotion distance, session 81.62.42.81.61.4-1.71.5
Degree of sensitization distance0.10.10.10.30.3-0.30.2
Degree of sensitization stereotypy0.80.91.2-1.1-1.00.4-1.0
Condit. Reinf. active minus inactive responses0.00.00.1-0.1-0.10.2-0.2
Condit. Reinf. active-inactive response ratio0.60.71.0-0.7-0.71.0-0.8
Condit. Reinf. active responses0.10.20.2-0.4-0.40.4-0.4
Condit. Reinf. inactive responses0.00.00.1-0.3-0.10.1-0.1
Incentive salience index mean0.10.10.2-0.2-0.10.4-0.2
Condit. Reinf. lever presses0.00.00.1-0.3-0.1-0.1-0.1
Time in familiar zone, hab. session 10.40.40.6-0.8-0.7-0.1-0.6
Time in novel zone, hab. session 11.61.63.2-1.0-1.01.8-1.0
Total zone transitions, hab. session 14.86.811.72.22.3-3.42.3
Total locomotion distance, hab. session 11.01.52.11.01.2-1.51.2
Locomotion velocity, hab. session 12.53.64.41.71.9-2.11.8
Time in familiar zone, hab. session 21.41.41.8-1.4-1.20.8-1.3
Time in novel zone, hab. session 20.40.40.50.70.70.10.7
Total zone transitions, hab. session 20.91.12.80.70.8-1.70.8
Total locomotion distance, hab. session 20.00.00.00.00.1-0.20.0
Locomotion velocity, hab. session 20.10.20.20.50.5-0.30.4
Novel to familiar place preference ratio2.52.73.21.81.7-1.41.7
Novelty place preference2.42.53.11.81.6-1.21.6
Time in novel zone, NPP test1.51.62.01.41.3-0.81.3
Total zone transitions, NPP test1.92.74.31.31.6-2.11.5
Total locomotion distance, NPP test0.30.40.60.40.7-0.70.6
Locomotion velocity, NPP test1.11.61.81.11.3-1.31.2
Pavlov. Cond. lever latency0.10.10.20.40.1-0.20.1
Pavlov. Cond. magazine entry latency1.92.46.1-1.2-1.02.5-1.1
Pavlov. Cond. change in total contacts0.20.20.5-0.5-0.20.7-0.2
Pavlov. Cond. index score1.11.42.6-1.1-0.91.6-0.9
Pavlov. Cond. latency score0.60.81.7-0.9-0.61.3-0.6
Pavlov. Cond. lever contacts0.00.00.1-0.4-0.10.0-0.1
Pavlov. Cond. magazine entry number2.53.25.01.71.5-2.21.5
Pavlov. Cond. intertrial magazine entries1.11.32.11.01.0-1.41.1
Pavlov. Cond. lever-magazine prob. diff.1.21.63.3-1.1-0.91.8-0.9
Pavlov. Cond. response bias1.41.72.9-1.3-1.11.7-1.1
Bone: apparent density1.52.55.0-1.2-1.32.2-1.3
Bone surface0.00.10.20.20.00.40.0
Bone volume0.30.51.2-0.3-0.61.1-0.6
Bone: connectivity density0.81.22.4-0.9-0.81.6-0.9
Bone: cortical apparent density0.10.20.4-0.00.4-0.60.4
Bone: cortical area0.10.20.30.50.30.50.4
Bone: cortical porosity0.60.61.6-0.6-0.61.3-0.5
Bone: cortical porosity0.50.61.9-0.4-0.31.4-0.3
Bone: cortical thickness0.30.50.50.70.70.50.7
Bone: cortical thickness1.31.61.81.21.31.11.3
Bone: cortical tissue density0.20.20.4-0.00.5-0.70.4
Bone: elastic displacement0.10.10.2-0.2-0.10.5-0.1
Bone: elastic work0.30.40.60.70.70.20.7
Bone: endosteal estimation0.20.51.01.00.6-0.50.7
Bone: endosteal perimeter0.10.10.20.40.1-0.50.2
Bone: final force0.40.62.2-0.1-0.21.5-0.2
Bone: final moment0.30.62.20.1-0.11.5-0.0
Bone: marrow area0.30.51.01.00.6-0.60.7
Bone: maximum diameter0.10.20.5-0.1-0.40.7-0.3
Bone: maximum force0.20.41.20.50.21.10.3
Bone: maximum moment0.30.51.20.70.41.10.5
Bone: minimum diameter0.50.91.61.30.9-0.21.0
Bone: periosteal estimation0.10.20.30.60.20.40.3
Bone: periosteal perimeter0.10.10.30.60.3-0.10.4
Bone: post-yield work0.20.20.40.70.4-0.20.5
Bone: stiffness0.10.20.30.60.30.60.4
Bone: tissue strength0.00.00.1-0.1-0.2-0.3-0.2
Bone: trabecular number2.23.45.8-1.6-1.62.4-1.6
Bone: trabecular spacing0.20.20.7-0.3-0.2-0.8-0.2
Bone: trabecular thickness0.30.31.30.2-0.01.10.0
Bone: trabecular tissue density0.00.10.10.20.3-0.20.3
Breakpoint value in progressive ratio session3.53.95.21.81.9-2.31.9
Distance traveled before self-admin0.50.50.80.60.9-0.50.7
Distance traveled after self-admin0.00.00.10.1-0.10.3-0.1
Delta time in closed arm before/after self-admin0.60.61.70.50.5-1.30.4
Delta time in open arm before/after self-admin0.10.10.1-0.4-0.3-0.3-0.3
Diff in mean of infusions in LGA sessions0.20.20.6-0.2-0.1-0.8-0.3
Extinction: sum of active levers before priming1.51.61.81.31.2-1.01.4
Active lever presses in extinction session 60.10.10.3-0.2-0.20.5-0.3
Delta distance traveled before/after self-admin0.80.91.3-0.8-1.10.6-1.1
Delta ambulatory time before/after self-admin0.90.91.2-0.8-1.11.0-1.0
Time in closed arm before self-admin1.11.31.8-1.1-1.01.3-1.0
Time in closed arm after self-admin0.00.00.0-0.1-0.1-0.1-0.1
Time in open arm before self-admin0.50.51.70.40.3-1.30.4
Time in open arm after self-admin0.30.41.0-0.5-0.4-1.0-0.4
Sum of active levers in priming session hrs 5-61.11.11.31.01.1-0.81.1
Time to tail flick, vehicle, before self-admin0.30.30.70.40.3-0.90.6
Time to tail flick, vehicle, after self-admin0.20.20.4-0.6-0.50.2-0.6
Time to tail flick, test, before self-admin0.10.10.3-0.0-0.1-0.5-0.2
Time to tail flick, test, after self-admin0.10.20.20.50.30.30.4
Delta time to tail flick, vehicle, before/after SA0.90.91.3-0.9-0.71.1-1.0
Delta time to tail flick, test, before/after SA0.80.71.00.80.80.71.0
Ambulatory time before self-admin0.30.40.50.50.7-0.60.6
Ambulatory time after self-admin0.10.10.20.50.20.10.3
Total heroin consumption0.20.20.70.10.2-0.80.1
Area under the delay curve0.91.01.31.11.10.51.1
Delay disc. indifference point, 0s delay0.30.40.60.60.70.00.8
Delay disc. indifference point, 16s delay0.50.51.30.50.41.10.4
Delay disc. indifference point, 2s delay0.80.91.00.91.00.91.0
Delay disc. indifference point, 24s delay0.80.71.11.01.0-0.30.9
Delay disc. indifference point, 4s delay5.35.67.62.62.7-0.72.8
Delay disc. indifference point, 8s delay0.30.30.50.40.50.70.5
Delay discount exponential model param1.41.52.0-1.4-1.4-0.3-1.4
Delay discount hyperbolic model param1.71.82.4-1.5-1.5-0.3-1.5
Fecal boli incidents, locomotor time 11.01.11.6-1.0-1.30.6-1.1
Change in fecal boli incidents, locomotor task1.31.31.71.21.3-0.71.2
Time >=10cm from walls, locomotor time 10.20.20.3-0.6-0.40.4-0.4
Bouts of movement, locomotor time 10.10.10.10.40.3-0.10.2
Total resting periods, locomotor time 10.20.20.30.60.5-0.00.4
Rest time, locomotor task time 10.10.10.20.20.30.50.2
Distance moved, locomotor task time 10.40.40.50.70.7-0.30.7
Vertical activity count, locomotor time 10.00.00.10.20.2-0.30.1
Time >=10cm from walls, locomotor time 20.10.10.30.00.20.50.2
Bouts of movement, locomotor time 20.20.20.3-0.5-0.50.5-0.4
Total resting periods, locomotor time 20.30.30.3-0.6-0.60.4-0.5
Rest time, locomotor task time 20.60.72.7-0.00.1-1.60.2
Distance moved, locomotor task time 21.51.82.51.61.60.11.5
Vertical activity count, locomotor time 21.11.21.61.31.20.61.1
Weight adjusted by age0.50.61.10.60.6-1.10.8
Seeking ratio, delayed vs. immediate footshock0.40.40.6-0.7-0.80.3-0.7
Locomotion in novel chamber0.20.30.30.40.60.60.5
Locomotion in novel chamber post-restriction2.53.03.5-1.9-1.81.4-1.8
Progressive ratio0.20.20.30.20.5-0.50.4
Food seeking constrained by brief footshock0.40.51.1-0.5-0.61.1-0.6
Seeking ratio, punishment vs. effort0.30.41.1-0.2-0.41.0-0.4
Run reversals in cocaine runway, females1.61.62.01.41.3-0.91.4
Run reversals in cocaine runway, males4.54.35.7-2.4-2.40.8-2.4
Latency to leave start box in cocaine runway0.30.40.6-0.5-0.8-0.2-0.7
Latency to leave start box in cocaine runway, F0.40.40.6-0.6-0.80.3-0.8
Latency to leave start box in cocaine runway, M0.20.10.3-0.3-0.50.0-0.5
Cd content in liver0.10.10.10.10.3-0.30.3
Co content in liver0.20.30.70.40.3-0.80.3
Cu content in liver1.01.23.80.60.6-1.90.7
Fe content in liver2.73.23.41.81.8-1.71.8
K content in liver0.10.10.30.0-0.00.50.1
Mg content in liver0.10.10.20.20.2-0.40.3
Mn content in liver0.20.20.9-0.2-0.0-0.9-0.0
Na content in liver1.31.41.7-1.3-1.30.8-1.2
Rb content in liver0.81.01.5-1.2-1.10.5-1.1
Se content in liver0.40.51.6-0.4-0.31.3-0.4
Sr content in liver2.32.12.51.51.6-1.11.6
Zn content in liver0.70.81.0-1.0-0.81.0-0.8