Hub : Genes

Kpnb1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	ENSRNOG00000009275	0.13	0.11	4.8e-03	0.06	0.03	0.05	0.05	6.3e-04	1.6e-02	1.4e-03	8.1e-04
2	Brain	gene expression	ENSRNOG00000009275	0.11	0.09	1.1e-03	0.04	0.03	0.04	0.04	8.3e-05	1.3e-03	2.7e-04	2.7e-04
3	Brain	mRNA stability	ENSRNOG00000009275	0.03	0.02	6.2e-03	0.01	0	0	0.01	2.3e-02	1.9e-01	1.8e-01	5.8e-02
4	Liver	gene expression	ENSRNOG00000009275	0.06	0.04	7.6e-07	0.05	0.06	0.05	0.05	6.9e-06	8.0e-07	1.1e-06	1.5e-06
5	OFC	gene expression	ENSRNOG00000009275	0.21	0.11	5.7e-04	0.09	0.05	0.1	0.06	3.5e-03	2.5e-02	3.0e-03	1.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
BMI with tail	8.6	27.9	37.3	4.3	4.3	-6.1	5.5	6.0
BMI without tail	0.7	1.5	3.2	0.3	0.2	-1.8	1.1	1.8
Body weight	0.6	2.7	5.2	-2.1	-2.3	-1.4	-0.7	1.1
Epididymis fat weight	0.1	0.2	0.6	-0.7	-0.8	0.0	-0.4	-0.2
Glucose	0.3	0.5	1.1	-0.4	-0.6	-1.0	0.3	0.9
Heart weight	0.4	0.6	1.4	0.1	0.1	-1.2	0.6	1.1
Left kidney weight	1.6	4.5	10.1	-3.0	-3.2	0.2	-1.8	-0.1
Right kidney weight	0.5	1.4	2.8	-1.5	-1.7	-0.9	-0.3	0.9
Tail length	13.5	40.8	51.8	-7.1	-7.2	5.3	-6.7	-5.4
Length with tail	11.3	41.4	59.0	-7.5	-7.7	4.7	-6.8	-4.9
Length without tail	1.2	2.6	4.7	-2.1	-2.2	0.7	-1.7	-0.9
Liver weight, left	0.8	1.4	1.6	-1.0	-1.1	1.3	-1.2	-1.2
Liver weight, right	2.5	4.1	6.6	-2.6	-2.6	1.3	-2.0	-1.3
Parametrial fat weight	0.1	0.1	0.2	0.4	0.3	-0.2	0.4	0.4
Retroperitoneal fat weight	0.3	0.8	1.2	-0.9	-1.0	-1.1	0.1	1.1
Intraocular pressure	1.6	2.2	3.1	-1.8	-1.7	1.3	-1.5	-1.1
Extensor digitorum longus weight	0.3	1.1	2.2	-1.4	-1.5	-0.6	-0.8	0.4
Soleus weight	0.6	1.7	2.8	0.7	0.7	-1.6	1.4	1.7
Tibialis anterior weight	0.4	1.3	1.8	-1.2	-1.4	0.8	-1.3	-0.9
Tibia length	0.3	0.7	1.3	-0.7	-0.8	-1.1	0.1	1.0
Number of licking bursts	0.1	0.1	0.2	0.4	0.2	0.3	0.1	-0.3
Food consumed during 24 hour testing period	1.1	1.3	1.7	-0.9	-1.0	1.3	-1.2	-1.3
Times rat made contact with spout	0.1	0.1	0.2	0.5	0.3	0.3	0.1	-0.2
Mean time between licks in bursts	0.0	0.1	0.1	0.2	0.0	-0.4	0.1	0.4
Mean num. licks in bursts	0.1	0.1	0.1	-0.3	-0.2	0.3	-0.3	-0.2
Std. dev. time between licks in bursts	1.1	1.3	1.7	1.0	1.0	-1.3	1.1	1.3
Water consumed over 24 hours	0.1	0.1	0.4	0.2	0.0	0.6	-0.2	-0.5
Indifference point 0 sec	0.7	1.1	1.9	0.6	0.7	-1.3	1.1	1.4
Indifference point AUC	0.1	0.1	0.2	0.3	0.1	0.3	-0.2	-0.4
Indifference point function ln k	0.1	0.1	0.3	-0.5	-0.5	-0.2	-0.1	0.3
Indifference point function log k	0.1	0.1	0.3	-0.5	-0.5	-0.2	-0.1	0.3
Delay discounting total patch changes 0 sec	0.6	1.0	1.9	0.3	0.4	-1.3	1.0	1.4
Delay discounting total patch changes 12 sec	0.6	0.8	0.9	1.0	0.9	-0.7	0.9	0.8
Delay discounting total patch changes 18 sec	1.8	2.4	2.7	1.6	1.6	-1.5	1.6	1.4
Delay discounting total patch changes 24 sec	1.2	1.5	1.9	1.0	1.0	-1.4	1.3	1.3
Delay discounting total patch changes 6 sec	1.1	1.7	2.0	1.2	1.2	-1.3	1.4	1.3
Delay discounting time to switch 0 sec	0.2	0.3	0.4	0.7	0.6	-0.3	0.6	0.3
Delay discounting water rate 0 sec	0.4	0.6	1.2	-0.4	-0.4	-1.1	0.3	1.1
Delay discounting water rate 12 sec	0.6	0.9	1.9	-1.3	-1.4	0.4	-0.9	-0.4
Delay discounting water rate 18 sec	1.0	1.3	1.9	-1.4	-1.4	0.9	-1.1	-0.9
Delay discounting water rate 24 sec	0.3	0.5	1.0	0.2	0.2	-1.0	0.6	0.9
Delay discounting water rate 6 sec	0.0	0.0	0.1	0.2	0.1	0.2	-0.1	-0.3
Locomotor activity	1.2	1.9	2.9	1.6	1.7	-1.1	1.4	1.1
Locomotor testing distance	2.8	4.7	7.3	2.6	2.7	-1.4	2.3	1.5
Locomotor testing rearing	1.0	1.5	3.3	1.7	1.8	-0.1	1.1	0.2
Light reinforcement 1	1.3	2.4	4.5	2.0	2.1	-0.7	1.5	0.8
Light reinforcement 2	0.2	0.2	0.4	0.6	0.5	-0.3	0.5	0.3
Reaction time number correct	0.2	0.3	0.4	-0.4	-0.3	0.6	-0.6	-0.6
Reaction time mean minus median	0.1	0.1	0.3	0.6	0.5	0.2	0.0	-0.3
Reaction time mean minus median AUC	0.3	0.4	0.9	0.9	0.8	0.4	0.2	-0.4
Reaction time num false alarms	0.1	0.2	0.4	0.1	0.2	0.6	-0.2	-0.5
Reaction time num false alarms AUC	0.2	0.2	0.5	-0.1	-0.0	0.7	-0.4	-0.6
Reaction time trials correct on left	0.2	0.3	0.4	-0.4	-0.3	0.6	-0.6	-0.6
Reaction time trials on left	0.2	0.3	0.4	-0.4	-0.3	0.6	-0.6	-0.6
Reaction time mean	0.8	1.0	2.0	1.4	1.3	-0.6	0.9	0.6
Reaction time mean AUC	0.7	0.9	1.7	1.3	1.2	-0.5	0.8	0.5
Median of all reaction times	1.3	1.7	2.9	1.7	1.6	-0.8	1.2	0.8
Reaction time omissions	0.1	0.1	0.2	0.4	0.4	-0.2	0.4	0.3
Reaction time false alarm rate	0.0	0.0	0.0	0.2	0.2	0.1	0.1	-0.1
Reaction time premature initiation rate	0.2	0.3	0.4	-0.7	-0.6	0.5	-0.6	-0.5
Reaction time premature initiations	0.6	0.9	0.9	-0.9	-0.8	0.9	-1.0	-0.9
Std. dev. reaction times	0.1	0.1	0.3	0.5	0.5	-0.1	0.1	-0.0
Reaction time trials completed	0.2	0.3	0.4	-0.4	-0.3	0.6	-0.6	-0.6
Reaction time trials AUC	0.2	0.3	0.5	-0.3	-0.3	0.7	-0.6	-0.6
Social response proportion	1.2	1.3	2.3	-1.5	-1.4	0.8	-1.2	-0.7
Social responses	0.0	0.0	0.1	-0.3	-0.2	0.1	-0.2	-0.0
Social time	0.4	0.5	1.2	1.0	1.1	0.0	0.5	-0.0
Conditioned locomotion	0.7	0.8	1.5	0.3	0.2	-1.2	0.9	1.2
Cocaine response after cond. corrected	4.1	4.6	7.8	1.2	1.3	-2.7	2.3	2.8
Cocaine response after cond. not corrected	2.1	2.4	4.6	0.5	0.6	-2.0	1.6	2.1
Cocaine response before conditioning	1.8	2.2	2.9	-1.2	-1.2	1.7	-1.5	-1.7
Saline control response	0.1	0.1	0.3	-0.0	0.1	0.5	-0.2	-0.5
Condit. Reinf. active minus inactive responses	0.2	0.2	0.4	0.6	0.5	-0.3	0.5	0.4
Condit. Reinf. active-inactive response ratio	0.9	0.9	1.6	1.3	1.1	-0.6	1.0	0.7
Condit. Reinf. active responses	0.1	0.1	0.2	0.5	0.5	-0.0	0.3	0.1
Condit. Reinf. inactive responses	0.1	0.1	0.3	0.1	0.2	0.5	-0.1	-0.5
Condit. Reinf. lever presses	0.4	0.6	0.8	-0.5	-0.6	0.9	-0.7	-0.9
Condit. Reinf. lever reinforcers received	0.0	0.0	0.1	0.3	0.3	0.2	0.1	-0.1
Pavlov. Cond. lever latency	0.6	0.8	0.9	-0.9	-0.7	0.9	-1.0	-0.9
Pavlov. Cond. magazine entry latency	0.8	0.9	1.4	-1.1	-1.2	0.8	-0.9	-0.8
Pavlov. Cond. change in total contacts	0.3	0.4	0.5	0.6	0.5	-0.7	0.7	0.7
Pavlov. Cond. index score	0.1	0.2	0.4	0.1	-0.1	-0.6	0.4	0.6
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.2	-0.4	-0.4	0.1	0.4
Pavlov. Cond. lever contacts	0.5	0.7	0.9	0.9	0.7	-0.8	0.9	0.8
Pavlov. Cond. magazine entry number	0.1	0.2	0.5	0.6	0.7	0.1	0.2	-0.1
Pavlov. Cond. intertrial magazine entries	1.3	1.6	2.6	-0.8	-0.7	1.6	-1.4	-1.6
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.5	0.0	-0.1	-0.7	0.4	0.7
Pavlov. Cond. response bias	0.4	0.6	0.8	0.6	0.5	-0.8	0.8	0.9
Conditioned reinforcement - actives	1.9	1.9	2.3	1.5	1.4	-1.2	1.5	1.2
Conditioned reinforcement - inactives	0.4	0.4	0.7	0.6	0.5	0.8	-0.2	-0.8
Conditioned locomotion	4.2	5.0	5.8	2.0	2.0	-2.3	2.4	2.4
Intermittent access intake day 1-15 change	1.5	1.5	2.1	0.8	1.0	-1.5	1.3	1.5
Intermittent access intake escalation	1.7	1.7	2.3	0.9	1.1	-1.5	1.4	1.5
Intermittent access intake escalation 2	1.2	1.1	1.7	0.7	0.9	-1.3	1.1	1.3
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.5	0.4	0.3	0.7	-0.2	-0.7
Intermitt. access day 15 inactive lever presses	1.9	2.1	4.2	2.0	2.1	-0.4	1.3	0.5
Intermitt. access escalation Index	1.7	1.5	3.1	0.4	0.4	-1.8	1.1	1.7
Intermittent access day 1 total infusions	0.0	0.0	0.1	-0.1	-0.1	0.3	-0.2	-0.3
Intermittent access day 15 total infusions	0.3	0.3	0.4	0.5	0.5	-0.6	0.6	0.6
Intermittent access terminal intake (last 3 days)	0.4	0.5	0.6	0.8	0.8	-0.5	0.7	0.5
Intermittent access total infusions	0.0	0.0	0.1	0.1	0.1	-0.2	0.2	0.2
Intermittent access day 1 locomotion	0.1	0.1	0.1	-0.1	-0.2	0.3	-0.2	-0.3
Intermittent access day 15 total locomotion	0.4	0.4	0.6	0.6	0.6	-0.6	0.7	0.6
Intermittent access total locomotion	0.7	0.8	1.0	0.7	0.8	-0.9	1.0	1.0
Intermittent access standard deviation	1.2	1.3	1.9	0.8	0.8	-1.4	1.1	1.4
Cocaine induced anxiety	0.0	0.0	0.1	-0.0	-0.2	-0.3	-0.1	0.2
Post-drug Anxiety	0.3	0.4	0.6	0.5	0.5	0.8	-0.3	-0.8
Baseline Anxiety	1.0	1.0	2.5	1.4	1.6	0.3	0.7	-0.2
Lifetime Intake	0.0	0.0	0.0	0.1	0.1	-0.1	0.1	0.1
Incentive Sensitization - Responses	0.2	0.2	0.4	0.7	0.5	-0.1	0.4	0.1
Incentive Sensitization - Breakpoint	0.3	0.3	0.4	0.7	0.6	-0.3	0.5	0.4
Progressive ratio test 1 active lever presses	0.1	0.1	0.3	-0.5	-0.5	0.1	-0.1	-0.0
Progressive ratio test 1 breakpoint	0.3	0.3	0.5	-0.7	-0.7	0.4	-0.4	-0.3
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.2	0.4	0.5	-0.2	0.4	0.3
Progressive ratio test 2 active lever presses	0.1	0.1	0.1	0.4	0.3	0.1	0.2	-0.1
Progressive ratio test 2 breakpoint	0.1	0.1	0.1	0.4	0.3	-0.0	0.3	0.0
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	0.4	0.4	0.4	0.0	-0.3
Total sessions with >9 infusions	0.4	0.5	0.8	0.3	0.3	-0.9	0.7	0.9
Short access day 1 total inactive lever presses	1.9	2.1	4.7	-0.2	-0.2	2.2	-1.2	-2.1
Short access day 10 total inactive lever presses	0.5	0.6	1.3	0.2	0.1	1.1	-0.7	-1.2
Short access day 1 total infusions	0.1	0.1	0.2	0.4	0.4	0.0	0.2	-0.0
Short access day 10 total infusions	0.2	0.3	0.5	0.2	0.3	-0.7	0.6	0.7
Short access total infusions	0.0	0.0	0.1	-0.1	-0.0	-0.2	0.1	0.2
Short access day 1 locomotion	0.7	0.7	0.9	0.7	0.6	-0.9	1.0	1.0
Short access day 10 total locomotion	0.3	0.3	0.5	0.2	0.6	-0.6	0.7	0.6
Short access total locomotion	0.5	0.5	0.9	0.3	0.4	-0.9	0.8	1.0
Compulsive drug intake	5.8	5.8	7.8	-1.8	-2.0	2.7	-2.5	-2.8
One hour access (0.3 mA shock)	0.3	0.4	0.7	-0.2	-0.1	0.9	-0.5	-0.9
One hour access (shock baseline)	2.3	2.7	3.0	1.5	1.6	-1.7	1.7	1.7
Number of responses in last shaping day	0.2	0.2	0.4	0.5	0.6	-0.2	0.3	0.3
Context. condit. distance diff. score	0.1	0.1	0.3	0.1	0.1	-0.4	0.3	0.6
Locomotion velocity, session 1	0.2	0.3	0.3	0.5	0.4	-0.6	0.6	0.4
Locomotion distance, session 1	3.1	4.0	4.8	-2.1	-2.1	1.7	-2.2	-1.9
Locomotion velocity, session 2	1.9	2.2	3.3	-1.8	-1.8	1.0	-1.5	-1.1
Locomotion distance, session 2	3.5	5.0	5.8	-2.2	-2.4	2.1	-2.4	-2.1
Locomotion velocity, session 3	0.2	0.2	0.4	-0.6	-0.6	0.1	-0.5	-0.2
Locomotion distance, session 3	3.9	4.3	4.7	-2.2	-2.1	1.9	-2.2	-1.9
Stereotopy head waving bouts, day 3	4.1	5.0	6.1	2.0	2.0	-2.3	2.5	2.4
Stereotopy head waving duration, day 3	2.4	2.9	3.8	1.3	1.3	-1.9	1.9	1.9
Locomotion velocity, session 7	1.7	1.9	2.4	-1.4	-1.5	1.2	-1.5	-1.3
Locomotion distance, session 7	5.1	6.4	7.3	-2.5	-2.5	2.5	-2.7	-2.5
Stereotopy head waving bouts, day 7	1.0	1.1	1.6	1.2	1.3	-0.8	1.1	0.8
Stereotopy head waving duration, day 7	0.5	0.7	1.1	1.0	1.1	-0.6	0.8	0.4
Locomotion velocity, session 8	0.1	0.1	0.3	-0.4	-0.5	-0.3	-0.3	0.1
Locomotion distance, session 8	1.1	1.6	2.4	-1.4	-1.6	0.9	-1.4	-0.9
Degree of sensitization distance	0.0	0.0	0.1	-0.2	-0.2	0.1	-0.2	-0.1
Degree of sensitization stereotypy	0.4	0.5	1.1	1.0	1.0	0.2	0.4	-0.3
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	0.2	0.0	0.4	-0.1	-0.3
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.6	0.8	0.6	-0.3	0.7	0.4
Condit. Reinf. active responses	0.1	0.1	0.2	0.4	0.3	0.3	0.1	-0.2
Condit. Reinf. inactive responses	0.1	0.1	0.3	0.1	0.2	0.6	-0.2	-0.5
Incentive salience index mean	0.1	0.2	0.5	0.2	0.0	0.7	-0.2	-0.6
Condit. Reinf. lever presses	0.5	0.6	1.6	0.1	-0.0	1.3	-0.5	-1.1
Time in familiar zone, hab. session 1	0.4	0.4	0.6	0.6	0.7	0.8	-0.0	-0.7
Time in novel zone, hab. session 1	2.2	2.2	3.3	1.0	1.0	-1.8	1.5	1.8
Total zone transitions, hab. session 1	5.6	7.9	9.4	-2.3	-2.5	3.0	-3.0	-3.1
Total locomotion distance, hab. session 1	1.9	2.7	4.0	-1.2	-1.3	2.0	-1.7	-1.9
Locomotion velocity, hab. session 1	3.2	4.6	5.3	-1.8	-2.0	2.3	-2.3	-2.3
Time in familiar zone, hab. session 2	0.9	0.9	1.7	1.3	1.3	-0.4	1.0	0.4
Time in novel zone, hab. session 2	0.2	0.2	0.5	-0.7	-0.7	0.1	-0.4	-0.0
Total zone transitions, hab. session 2	1.2	1.6	2.4	-0.8	-0.9	1.6	-1.3	-1.5
Total locomotion distance, hab. session 2	0.0	0.0	0.0	-0.0	-0.2	0.2	-0.1	-0.1
Locomotion velocity, hab. session 2	0.1	0.2	0.3	-0.4	-0.6	0.3	-0.4	-0.2
Novel to familiar place preference ratio	1.6	1.7	2.7	-1.7	-1.6	0.8	-1.4	-0.8
Novelty place preference	1.7	1.8	2.7	-1.6	-1.6	0.9	-1.4	-0.9
Time in novel zone, NPP test	1.1	1.2	1.8	-1.3	-1.3	0.8	-1.2	-0.8
Total zone transitions, NPP test	2.9	4.1	5.3	-1.5	-1.7	2.3	-2.1	-2.3
Total locomotion distance, NPP test	0.6	0.8	1.2	-0.6	-0.7	1.1	-1.0	-1.1
Locomotion velocity, NPP test	1.3	1.9	2.2	-1.2	-1.4	1.4	-1.5	-1.4
Pavlov. Cond. lever latency	0.8	1.0	2.3	-0.2	-0.0	-1.5	0.7	1.4
Pavlov. Cond. magazine entry latency	0.4	0.6	1.2	1.1	1.0	0.1	0.8	0.1
Pavlov. Cond. change in total contacts	0.9	1.0	2.4	0.2	0.2	1.6	-0.5	-1.5
Pavlov. Cond. index score	0.4	0.5	0.9	0.9	0.8	0.8	0.2	-0.7
Pavlov. Cond. latency score	0.3	0.4	0.8	0.7	0.5	0.9	-0.0	-0.8
Pavlov. Cond. lever contacts	0.9	1.1	2.6	0.2	0.0	1.6	-0.7	-1.5
Pavlov. Cond. magazine entry number	0.9	1.1	2.4	-1.6	-1.5	-0.5	-0.8	0.3
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.2	-1.1	-1.1	0.7	-1.0	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.9	1.0	0.8	0.8	0.3	-0.6
Pavlov. Cond. response bias	0.6	0.7	1.2	1.1	1.0	0.8	0.3	-0.7
Bone: apparent density	1.3	2.1	2.7	1.3	1.3	-1.4	1.6	1.6
Bone surface	0.1	0.2	0.6	0.0	-0.0	-0.6	0.4	0.8
Bone volume	0.6	1.1	2.0	0.6	0.6	-1.3	1.1	1.4
Bone: connectivity density	0.3	0.5	0.8	0.9	0.8	-0.3	0.8	0.5
Bone: cortical apparent density	3.3	4.3	9.7	-0.5	-0.4	3.1	-1.7	-2.9
Bone: cortical area	0.0	0.1	0.2	-0.3	-0.4	-0.1	-0.0	0.2
Bone: cortical porosity	0.5	0.5	0.6	0.6	0.5	-0.8	0.8	0.8
Bone: cortical porosity	0.3	0.3	0.5	0.3	0.3	-0.7	0.6	0.7
Bone: cortical thickness	0.3	0.5	0.6	-0.7	-0.8	0.7	-0.6	-0.7
Bone: cortical thickness	1.2	1.4	1.8	-1.4	-1.3	1.1	-1.1	-1.0
Bone: cortical tissue density	3.5	4.5	10.1	-0.5	-0.4	3.2	-1.7	-3.0
Bone: elastic displacement	0.1	0.1	0.1	0.1	0.2	-0.3	0.3	0.3
Bone: elastic work	0.2	0.2	0.5	-0.7	-0.7	-0.1	-0.2	0.1
Bone: endosteal estimation	0.2	0.5	0.8	-0.6	-0.6	-0.9	0.0	0.9
Bone: endosteal perimeter	0.2	0.4	1.0	-0.1	-0.1	-1.0	0.3	1.0
Bone: final force	0.1	0.2	0.4	0.2	0.1	-0.6	0.5	0.6
Bone: final moment	0.1	0.2	0.5	0.1	0.1	-0.7	0.5	0.7
Bone: marrow area	0.2	0.4	0.6	-0.6	-0.6	-0.8	-0.0	0.8
Bone: maximum diameter	0.3	0.5	0.9	0.4	0.3	-0.9	0.6	0.9
Bone: maximum force	0.3	0.5	1.2	-0.2	-0.2	-1.0	0.5	1.1
Bone: maximum moment	0.3	0.6	1.2	-0.4	-0.4	-1.0	0.4	1.1
Bone: minimum diameter	0.2	0.4	0.9	-0.9	-0.9	-0.3	-0.4	0.2
Bone: periosteal estimation	0.2	0.4	0.8	-0.2	-0.2	-0.9	0.3	0.9
Bone: periosteal perimeter	0.1	0.2	0.5	-0.3	-0.4	-0.7	0.1	0.7
Bone: post-yield work	0.1	0.2	0.3	-0.4	-0.4	-0.4	0.0	0.5
Bone: stiffness	0.1	0.1	0.2	-0.3	-0.4	-0.3	0.0	0.4
Bone: tissue strength	0.1	0.1	0.1	0.2	0.2	-0.2	0.3	0.3
Bone: trabecular number	1.2	1.8	2.6	1.6	1.5	-0.9	1.5	1.0
Bone: trabecular spacing	0.0	0.0	0.1	0.2	0.3	0.1	-0.1	-0.2
Bone: trabecular thickness	0.7	0.8	1.7	-0.0	-0.0	-1.3	0.8	1.3
Bone: trabecular tissue density	0.1	0.2	0.3	-0.3	-0.3	0.5	-0.4	-0.6
Breakpoint value in progressive ratio session	4.4	4.9	6.4	-1.9	-1.9	2.4	-2.3	-2.5
Distance traveled before self-admin	0.6	0.6	0.8	-0.7	-0.9	0.7	-0.8	-0.8
Distance traveled after self-admin	0.8	0.9	2.0	0.1	0.1	-1.4	0.8	1.3
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	-0.4	-0.5	0.1	-0.4	-0.2
Delta time in open arm before/after self-admin	0.1	0.1	0.1	0.3	0.2	0.4	-0.2	-0.4
Diff in mean of infusions in LGA sessions	0.4	0.5	1.3	0.2	0.1	0.9	-0.4	-1.1
Extinction: sum of active levers before priming	1.1	1.2	1.6	-1.3	-1.2	0.8	-1.1	-0.9
Active lever presses in extinction session 6	0.1	0.1	0.2	0.4	0.2	-0.2	0.4	0.3
Delta distance traveled before/after self-admin	2.2	2.4	3.5	1.1	1.1	-1.9	1.6	1.9
Delta ambulatory time before/after self-admin	2.3	2.5	3.8	1.0	1.1	-1.9	1.6	2.0
Time in closed arm before self-admin	0.8	0.9	1.1	1.0	1.0	-0.9	1.0	0.8
Time in closed arm after self-admin	0.2	0.2	0.4	0.1	0.1	-0.6	0.3	0.5
Time in open arm before self-admin	0.0	0.0	0.1	-0.2	-0.3	0.1	-0.3	-0.2
Time in open arm after self-admin	0.2	0.2	0.3	0.4	0.4	0.5	-0.2	-0.5
Sum of active levers in priming session hrs 5-6	2.6	2.5	4.1	-1.1	-1.1	1.9	-1.5	-2.0
Time to tail flick, vehicle, before self-admin	1.1	1.1	2.1	-0.6	-0.3	1.5	-0.9	-1.4
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.4	0.6	0.5	-0.2	0.4	0.3
Time to tail flick, test, before self-admin	0.0	0.0	0.0	0.1	0.1	0.1	0.0	0.1
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.3	-0.3	-0.4	0.1	0.4
Delta time to tail flick, vehicle, before/after SA	1.1	1.0	1.5	1.0	0.7	-1.1	1.1	1.2
Delta time to tail flick, test, before/after SA	0.4	0.3	0.7	-0.8	-0.8	0.2	-0.4	-0.3
Ambulatory time before self-admin	0.3	0.4	0.5	-0.6	-0.7	0.4	-0.7	-0.6
Ambulatory time after self-admin	1.0	1.1	2.7	-0.2	-0.2	-1.6	0.7	1.5
Total heroin consumption	0.9	1.1	2.4	-0.1	-0.2	1.5	-0.9	-1.5
Area under the delay curve	0.6	0.7	1.3	-1.1	-1.1	0.3	-0.8	-0.4
Delay disc. indifference point, 0s delay	0.7	0.8	1.3	-0.7	-0.7	0.9	-0.9	-1.1
Delay disc. indifference point, 16s delay	0.2	0.2	0.5	-0.4	-0.4	-0.6	0.2	0.7
Delay disc. indifference point, 2s delay	0.6	0.6	1.0	-1.0	-1.0	0.4	-0.7	-0.6
Delay disc. indifference point, 24s delay	0.6	0.6	0.9	-1.0	-1.0	0.5	-0.7	-0.4
Delay disc. indifference point, 4s delay	5.3	5.6	7.5	-2.7	-2.7	1.8	-2.5	-1.9
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	-0.5	-0.5	0.1	-0.3	-0.1
Delay discount exponential model param	1.0	1.1	2.0	1.4	1.4	-0.4	1.0	0.5
Delay discount hyperbolic model param	1.3	1.4	2.4	1.5	1.5	-0.6	1.2	0.7
Fecal boli incidents, locomotor time 1	2.0	2.2	3.0	1.2	1.3	-1.6	1.5	1.7
Change in fecal boli incidents, locomotor task	1.9	1.8	2.0	-1.3	-1.3	1.3	-1.4	-1.4
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	0.5	0.4	0.2	0.1	-0.2
Bouts of movement, locomotor time 1	0.0	0.1	0.1	-0.3	-0.3	-0.1	-0.0	0.3
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.5	-0.5	-0.2	-0.0	0.4
Rest time, locomotor task time 1	0.2	0.2	0.4	-0.3	-0.3	-0.5	0.2	0.7
Distance moved, locomotor task time 1	0.7	0.8	1.1	-0.7	-0.7	1.0	-0.9	-1.1
Vertical activity count, locomotor time 1	0.1	0.1	0.2	-0.1	-0.2	0.3	-0.3	-0.4
Time >=10cm from walls, locomotor time 2	0.3	0.3	0.7	-0.2	-0.2	0.8	-0.4	-0.7
Bouts of movement, locomotor time 2	0.1	0.2	0.3	0.5	0.5	-0.1	0.4	0.3
Total resting periods, locomotor time 2	0.2	0.2	0.3	0.6	0.6	-0.2	0.5	0.4
Rest time, locomotor task time 2	0.5	0.5	1.2	-0.1	-0.2	1.1	-0.8	-1.0
Distance moved, locomotor task time 2	0.9	1.1	2.3	-1.5	-1.5	0.2	-0.9	-0.3
Vertical activity count, locomotor time 2	0.6	0.6	1.4	-1.2	-1.2	-0.4	-0.4	0.3
Weight adjusted by age	0.7	0.7	1.1	-0.8	-0.6	0.9	-0.9	-1.0
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	0.6	0.7	0.8	-0.6	0.8	0.6
Locomotion in novel chamber	0.5	0.6	1.2	-0.5	-0.6	1.1	-0.7	-1.0
Locomotion in novel chamber post-restriction	2.4	2.9	3.9	1.8	2.0	-1.3	1.8	1.5
Progressive ratio	0.5	0.5	0.9	-0.4	-0.5	0.9	-0.7	-1.0
Food seeking constrained by brief footshock	0.4	0.5	0.8	0.6	0.5	-0.7	0.9	0.8
Seeking ratio, punishment vs. effort	0.5	0.6	1.1	0.4	0.4	-0.9	0.8	1.1
Run reversals in cocaine runway, females	0.8	0.8	1.8	-1.4	-1.0	0.3	-0.8	-0.3
Run reversals in cocaine runway, males	3.1	3.0	5.5	2.4	2.4	-0.8	1.6	0.8
Latency to leave start box in cocaine runway	1.3	1.4	2.5	0.7	0.8	-1.6	1.1	1.5
Latency to leave start box in cocaine runway, F	2.2	2.4	4.5	0.8	0.8	-2.1	1.4	2.1
Latency to leave start box in cocaine runway, M	0.3	0.3	0.4	0.5	0.5	-0.5	0.6	0.5
Cd content in liver	0.4	0.4	1.0	-0.3	-0.2	1.0	-0.6	-0.9
Co content in liver	0.0	0.0	0.1	-0.3	-0.3	-0.1	-0.2	0.1
Cu content in liver	1.2	1.4	2.4	-0.7	-0.6	1.5	-1.3	-1.5
Fe content in liver	2.1	2.5	3.1	-1.8	-1.8	1.3	-1.7	-1.3
K content in liver	0.1	0.1	0.1	-0.0	-0.0	-0.3	0.2	0.3
Mg content in liver	0.4	0.4	0.8	-0.2	-0.2	0.9	-0.6	-0.9
Mn content in liver	1.2	1.4	3.1	0.0	0.0	1.8	-0.9	-1.7
Na content in liver	1.1	1.2	1.6	1.2	1.3	-0.9	1.2	0.8
Rb content in liver	0.4	0.5	1.2	1.1	1.0	0.3	0.4	-0.3
Se content in liver	0.1	0.1	0.2	0.4	0.3	-0.3	0.5	0.4
Sr content in liver	2.2	2.0	2.4	-1.6	-1.5	1.3	-1.5	-1.3
Zn content in liver	0.3	0.4	0.9	0.8	0.9	0.0	0.5	0.1