Hub : Genes

Amn

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression ENSRNOG00000009050 0.22 0.19 7.9e-09 0.1 0.11 0.1 0.1 9.8e-08 1.2e-08 5.2e-08 4.9e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1
BMI with tail1.65.25.22.3
BMI without tail0.00.00.00.2
Body weight0.20.80.8-0.9
Epididymis fat weight4.911.311.33.4
Glucose0.40.60.6-0.7
Heart weight0.00.00.00.2
Left kidney weight0.41.21.2-1.1
Right kidney weight0.20.50.5-0.7
Tail length3.610.710.7-3.3
Length with tail3.512.812.8-3.6
Length without tail0.71.61.6-1.3
Liver weight, left4.77.67.6-2.8
Liver weight, right0.00.00.0-0.1
Parametrial fat weight0.10.20.2-0.4
Retroperitoneal fat weight0.10.30.30.5
Intraocular pressure0.10.10.10.3
Extensor digitorum longus weight6.425.925.9-5.1
Soleus weight0.00.10.10.3
Tibialis anterior weight0.41.41.4-1.2
Tibia length0.61.61.6-1.3
Number of licking bursts0.40.50.5-0.7
Food consumed during 24 hour testing period0.30.30.3-0.6
Times rat made contact with spout0.10.10.1-0.3
Mean time between licks in bursts0.71.01.01.0
Mean num. licks in bursts0.20.20.20.5
Std. dev. time between licks in bursts0.80.90.91.0
Water consumed over 24 hours2.93.43.4-1.9
Indifference point 0 sec1.93.03.0-1.7
Indifference point AUC3.03.53.5-1.9
Indifference point function ln k0.40.50.5-0.7
Indifference point function log k0.40.50.5-0.7
Delay discounting total patch changes 0 sec2.03.23.2-1.8
Delay discounting total patch changes 12 sec2.53.43.4-1.8
Delay discounting total patch changes 18 sec0.50.60.6-0.8
Delay discounting total patch changes 24 sec0.10.10.1-0.4
Delay discounting total patch changes 6 sec1.72.62.6-1.6
Delay discounting time to switch 0 sec10.816.516.54.1
Delay discounting water rate 0 sec17.527.827.8-5.3
Delay discounting water rate 12 sec10.916.316.3-4.0
Delay discounting water rate 18 sec4.76.26.2-2.5
Delay discounting water rate 24 sec4.76.56.5-2.5
Delay discounting water rate 6 sec4.16.06.0-2.4
Locomotor activity0.00.00.00.0
Locomotor testing distance0.00.00.0-0.2
Locomotor testing rearing2.53.93.92.0
Light reinforcement 10.00.10.10.3
Light reinforcement 21.11.51.51.2
Reaction time number correct1.82.62.6-1.6
Reaction time mean minus median0.00.00.00.0
Reaction time mean minus median AUC0.00.00.00.0
Reaction time num false alarms0.30.40.4-0.6
Reaction time num false alarms AUC0.71.01.0-1.0
Reaction time trials correct on left1.82.62.6-1.6
Reaction time trials on left1.82.62.6-1.6
Reaction time mean0.60.80.80.9
Reaction time mean AUC0.30.40.40.7
Median of all reaction times0.50.60.60.8
Reaction time omissions1.62.22.2-1.5
Reaction time false alarm rate0.00.00.0-0.2
Reaction time premature initiation rate0.71.01.0-1.0
Reaction time premature initiations1.82.52.5-1.6
Std. dev. reaction times0.00.00.00.2
Reaction time trials completed1.82.62.6-1.6
Reaction time trials AUC2.02.82.8-1.7
Social response proportion0.20.30.3-0.5
Social responses0.10.10.10.4
Social time1.01.31.3-1.1
Conditioned locomotion0.60.70.7-0.8
Cocaine response after cond. corrected0.20.30.30.5
Cocaine response after cond. not corrected1.41.51.51.2
Cocaine response before conditioning2.73.43.41.8
Saline control response0.40.60.60.8
Condit. Reinf. active minus inactive responses0.40.60.6-0.7
Condit. Reinf. active-inactive response ratio0.40.40.4-0.7
Condit. Reinf. active responses0.00.00.0-0.0
Condit. Reinf. inactive responses0.60.80.80.9
Condit. Reinf. lever presses1.31.81.81.3
Condit. Reinf. lever reinforcers received0.00.00.00.0
Pavlov. Cond. lever latency1.82.42.4-1.6
Pavlov. Cond. magazine entry latency5.25.95.92.4
Pavlov. Cond. change in total contacts4.56.36.32.5
Pavlov. Cond. index score5.06.66.62.6
Pavlov. Cond. latency score4.96.26.22.5
Pavlov. Cond. lever contacts2.02.82.81.7
Pavlov. Cond. magazine entry number4.55.55.5-2.3
Pavlov. Cond. intertrial magazine entries3.54.54.5-2.1
Pavlov. Cond. lever-magazine prob. diff.6.07.87.82.8
Pavlov. Cond. response bias3.44.64.62.1
Conditioned reinforcement - actives1.41.41.4-1.2
Conditioned reinforcement - inactives0.20.30.3-0.5
Conditioned locomotion1.11.31.31.1
Intermittent access intake day 1-15 change1.81.81.81.3
Intermittent access intake escalation2.02.02.01.4
Intermittent access intake escalation 20.10.10.10.4
Intermitt. access day 1 inactive lever presses2.32.42.4-1.6
Intermitt. access day 15 inactive lever presses0.50.60.6-0.8
Intermitt. access escalation Index0.60.50.5-0.7
Intermittent access day 1 total infusions0.30.30.30.6
Intermittent access day 15 total infusions1.92.12.11.5
Intermittent access terminal intake (last 3 days)2.12.32.31.5
Intermittent access total infusions0.80.90.91.0
Intermittent access day 1 locomotion1.01.01.01.0
Intermittent access day 15 total locomotion0.40.40.40.6
Intermittent access total locomotion0.50.60.60.8
Intermittent access standard deviation3.94.14.12.0
Cocaine induced anxiety3.43.93.9-2.0
Post-drug Anxiety2.73.03.0-1.7
Baseline Anxiety1.81.91.91.4
Lifetime Intake0.50.50.50.7
Incentive Sensitization - Responses0.00.00.00.0
Incentive Sensitization - Breakpoint0.00.00.0-0.1
Progressive ratio test 1 active lever presses0.10.10.10.3
Progressive ratio test 1 breakpoint0.20.20.20.5
Progressive ratio test 1 inactive lever presses2.22.32.3-1.5
Progressive ratio test 2 active lever presses0.00.00.00.2
Progressive ratio test 2 breakpoint0.00.00.00.1
Progressive ratio test 2 inactive lever presses0.70.90.9-0.9
Total sessions with >9 infusions0.30.30.30.5
Short access day 1 total inactive lever presses0.10.10.10.4
Short access day 10 total inactive lever presses0.50.50.5-0.7
Short access day 1 total infusions0.10.10.1-0.4
Short access day 10 total infusions0.60.70.70.8
Short access total infusions0.30.40.40.6
Short access day 1 locomotion1.21.31.31.1
Short access day 10 total locomotion0.70.80.80.9
Short access total locomotion0.20.20.20.4
Compulsive drug intake0.00.00.00.1
One hour access (0.3 mA shock)0.00.00.0-0.2
One hour access (shock baseline)0.10.10.10.2
Number of responses in last shaping day0.10.10.10.3
Context. condit. distance diff. score1.31.61.6-1.3
Locomotion velocity, session 10.60.70.7-0.8
Locomotion distance, session 10.10.10.10.4
Locomotion velocity, session 20.10.10.10.4
Locomotion distance, session 20.20.20.20.5
Locomotion velocity, session 30.70.80.80.9
Locomotion distance, session 30.00.00.00.1
Stereotopy head waving bouts, day 30.10.20.2-0.4
Stereotopy head waving duration, day 30.20.30.3-0.5
Locomotion velocity, session 71.41.61.61.2
Locomotion distance, session 71.31.71.71.3
Stereotopy head waving bouts, day 70.50.50.5-0.7
Stereotopy head waving duration, day 70.10.20.2-0.4
Locomotion velocity, session 80.00.10.1-0.2
Locomotion distance, session 80.00.00.00.2
Degree of sensitization distance0.20.20.20.5
Degree of sensitization stereotypy0.10.10.1-0.2
Condit. Reinf. active minus inactive responses0.50.50.50.7
Condit. Reinf. active-inactive response ratio2.12.32.31.5
Condit. Reinf. active responses0.30.30.30.6
Condit. Reinf. inactive responses1.61.91.9-1.4
Incentive salience index mean0.40.50.50.7
Condit. Reinf. lever presses0.20.30.30.5
Time in familiar zone, hab. session 11.61.51.51.2
Time in novel zone, hab. session 10.20.10.1-0.4
Total zone transitions, hab. session 10.50.70.70.8
Total locomotion distance, hab. session 10.00.00.0-0.1
Locomotion velocity, hab. session 10.30.40.4-0.6
Time in familiar zone, hab. session 21.61.61.61.3
Time in novel zone, hab. session 20.30.30.3-0.5
Total zone transitions, hab. session 20.30.40.40.6
Total locomotion distance, hab. session 20.60.80.8-0.9
Locomotion velocity, hab. session 20.70.90.9-1.0
Novel to familiar place preference ratio0.10.10.10.3
Novelty place preference0.10.10.10.3
Time in novel zone, NPP test0.00.00.00.2
Total zone transitions, NPP test0.00.00.00.0
Total locomotion distance, NPP test0.10.10.1-0.4
Locomotion velocity, NPP test0.10.20.2-0.4
Pavlov. Cond. lever latency0.60.70.7-0.8
Pavlov. Cond. magazine entry latency0.91.21.21.1
Pavlov. Cond. change in total contacts0.50.50.50.7
Pavlov. Cond. index score0.81.01.01.0
Pavlov. Cond. latency score0.50.60.60.8
Pavlov. Cond. lever contacts0.81.01.01.0
Pavlov. Cond. magazine entry number1.21.51.5-1.2
Pavlov. Cond. intertrial magazine entries4.75.75.7-2.4
Pavlov. Cond. lever-magazine prob. diff.0.60.70.70.8
Pavlov. Cond. response bias1.62.02.01.4
Bone: apparent density0.10.20.20.4
Bone surface0.00.00.0-0.1
Bone volume0.00.00.00.2
Bone: connectivity density0.00.00.0-0.1
Bone: cortical apparent density7.19.39.3-3.0
Bone: cortical area1.32.02.0-1.4
Bone: cortical porosity0.10.10.10.4
Bone: cortical porosity0.50.50.50.7
Bone: cortical thickness0.91.51.5-1.2
Bone: cortical thickness0.70.90.9-0.9
Bone: cortical tissue density7.59.79.7-3.1
Bone: elastic displacement0.50.50.5-0.7
Bone: elastic work0.20.30.3-0.5
Bone: endosteal estimation0.00.00.00.1
Bone: endosteal perimeter0.10.30.3-0.6
Bone: final force0.40.60.6-0.8
Bone: final moment0.50.80.8-0.9
Bone: marrow area0.00.00.00.1
Bone: maximum diameter0.40.70.7-0.9
Bone: maximum force0.30.60.6-0.8
Bone: maximum moment0.40.60.6-0.8
Bone: minimum diameter0.71.31.3-1.2
Bone: periosteal estimation0.51.01.0-1.0
Bone: periosteal perimeter0.40.70.7-0.8
Bone: post-yield work0.91.31.3-1.1
Bone: stiffness1.82.92.9-1.7
Bone: tissue strength0.20.20.2-0.4
Bone: trabecular number0.00.00.00.2
Bone: trabecular spacing0.00.00.0-0.1
Bone: trabecular thickness0.10.10.1-0.4
Bone: trabecular tissue density0.00.00.0-0.1
Breakpoint value in progressive ratio session0.00.00.00.0
Distance traveled before self-admin0.00.00.0-0.0
Distance traveled after self-admin0.50.50.5-0.7
Delta time in closed arm before/after self-admin0.00.00.00.2
Delta time in open arm before/after self-admin0.60.60.6-0.8
Diff in mean of infusions in LGA sessions0.00.00.00.1
Extinction: sum of active levers before priming0.00.00.00.0
Active lever presses in extinction session 61.41.41.4-1.2
Delta distance traveled before/after self-admin0.00.00.00.2
Delta ambulatory time before/after self-admin0.20.30.3-0.5
Time in closed arm before self-admin2.42.82.81.7
Time in closed arm after self-admin1.51.61.61.2
Time in open arm before self-admin5.05.35.3-2.3
Time in open arm after self-admin3.23.53.5-1.9
Sum of active levers in priming session hrs 5-60.40.40.40.6
Time to tail flick, vehicle, before self-admin0.91.01.0-1.0
Time to tail flick, vehicle, after self-admin0.40.40.40.6
Time to tail flick, test, before self-admin0.10.10.1-0.2
Time to tail flick, test, after self-admin1.61.71.7-1.3
Delta time to tail flick, vehicle, before/after SA0.40.40.40.7
Delta time to tail flick, test, before/after SA1.00.90.9-0.9
Ambulatory time before self-admin0.00.00.00.1
Ambulatory time after self-admin0.00.00.00.1
Total heroin consumption1.21.41.4-1.2
Area under the delay curve0.00.00.00.2
Delay disc. indifference point, 0s delay0.00.00.0-0.2
Delay disc. indifference point, 16s delay0.00.00.00.1
Delay disc. indifference point, 2s delay0.00.00.0-0.0
Delay disc. indifference point, 24s delay0.00.00.0-0.1
Delay disc. indifference point, 4s delay0.10.10.1-0.3
Delay disc. indifference point, 8s delay0.20.20.20.4
Delay discount exponential model param0.00.00.0-0.1
Delay discount hyperbolic model param0.00.00.0-0.1
Fecal boli incidents, locomotor time 10.40.40.40.7
Change in fecal boli incidents, locomotor task0.00.00.0-0.2
Time >=10cm from walls, locomotor time 10.40.40.40.6
Bouts of movement, locomotor time 10.50.50.50.7
Total resting periods, locomotor time 10.60.70.70.8
Rest time, locomotor task time 10.60.70.7-0.8
Distance moved, locomotor task time 11.21.31.31.1
Vertical activity count, locomotor time 10.10.10.1-0.4
Time >=10cm from walls, locomotor time 20.40.40.4-0.6
Bouts of movement, locomotor time 23.43.63.6-1.9
Total resting periods, locomotor time 22.72.92.9-1.7
Rest time, locomotor task time 20.81.01.0-1.0
Distance moved, locomotor task time 21.01.11.11.1
Vertical activity count, locomotor time 20.10.10.1-0.3
Weight adjusted by age0.00.00.0-0.1
Seeking ratio, delayed vs. immediate footshock0.50.60.6-0.8
Locomotion in novel chamber6.27.67.6-2.8
Locomotion in novel chamber post-restriction0.00.00.0-0.2
Progressive ratio0.60.70.7-0.8
Food seeking constrained by brief footshock1.92.32.3-1.5
Seeking ratio, punishment vs. effort0.00.00.0-0.1
Run reversals in cocaine runway, females1.51.51.51.2
Run reversals in cocaine runway, males0.80.70.7-0.9
Latency to leave start box in cocaine runway0.40.50.50.7
Latency to leave start box in cocaine runway, F0.50.50.50.7
Latency to leave start box in cocaine runway, M0.20.20.20.4
Cd content in liver1.31.51.5-1.2
Co content in liver0.91.01.0-1.0
Cu content in liver0.70.80.80.9
Fe content in liver0.10.10.10.3
K content in liver0.00.00.0-0.2
Mg content in liver0.00.00.0-0.1
Mn content in liver0.20.20.20.5
Na content in liver0.00.00.00.2
Rb content in liver0.40.50.5-0.7
Se content in liver0.10.10.1-0.4
Sr content in liver1.00.90.9-1.0
Zn content in liver0.60.70.7-0.8